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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:wortmannin
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Accession:CHEBI:52289 term browser browse the term
Definition:A delta-lactone that has formula C23H24O8.
Synonyms:exact_synonym: (1S,6bR,9aS,11R,11bR)-9a,11b-dimethyl-1-[(methyloxy)methyl]-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate
 related_synonym: Formula=C23H24O8;   InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1;   InChIKey=QDLHCMPXEPAAMD-QAIWCSMKSA-N;   SMILES=[H][C@@]12CCC(=O)[C@@]1(C)C[C@@H](OC(C)=O)C1=C2C(=O)c2occ3C(=O)O[C@H](COC)[C@@]1(C)c23;   Wartmannin
 xref: Beilstein:67676;   CAS:19545-26-7;   KEGG:C15181;   KNApSAcK:C00023672;   LINCS:LSM-3947
 xref_mesh: MESH:C009687
 xref: PDBeChem:KWT;   PMID:22003059;   PMID:22056625;   PMID:22524784;   Reaxys:67676


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wortmannin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 affects localization
decreases activity
multiple interactions
EXP
ISO
wortmannin affects the localization of ABCB11 protein
wortmannin results in decreased activity of ABCB11 protein
wortmannin inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]
CTD PMID:12702492 PMID:20815017 PMID:20829430 PMID:23956101 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects localization
multiple interactions
EXP wortmannin affects the localization of ABCC2 protein
Wortmannin inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; Wortmannin inhibits the reaction [Taurolithocholic Acid results in decreased activity of and affects the localization of ABCC2 protein]
CTD PMID:12702492 PMID:20815017 PMID:31300867 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions EXP wortmannin inhibits the reaction [bisphenol A results in decreased expression of ACOX1 mRNA] CTD PMID:23399309 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Agt angiotensinogen multiple interactions EXP Wortmannin inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; Wortmannin inhibits the reaction [AGT protein results in increased expression of POSTN mRNA]; Wortmannin inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein] CTD PMID:15121739 PMID:15849355 PMID:25398788 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions EXP Wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of AHR mRNA]]; Wortmannin inhibits the reaction [INS1 protein results in decreased expression of AHR mRNA] CTD PMID:26466350 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 decreases localization EXP wortmannin results in decreased localization of AIFM1 protein CTD PMID:21256120 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
decreases expression
decreases activity
ISO
EXP
Wortmannin inhibits the reaction [4,4'-hexafluorisopropylidene diphenol results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [4-hydroxyestradiol results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased activity of and results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [[[MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein] which results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [arsenite results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [baicalein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [C5 protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Caffeine results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Camptothecin results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Capsaicin results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Copper results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [Copper Sulfate results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [CXCL8 results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Estrone results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Hexanones results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Humic Substances results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Hydrocarbons, Chlorinated results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [ochratoxin A results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Simvastatin promotes the reaction [[Nifedipine co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Zinc results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Zinc results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin promotes the reaction [evodiamine results in decreased phosphorylation of AKT1 protein]
wortmannin results in decreased phosphorylation of AKT1 protein
resveratrol promotes the reaction [wortmannin results in decreased phosphorylation of AKT1 protein]; Thimerosal promotes the reaction [wortmannin results in decreased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [INS1 protein results in increased activity of AKT1 protein]; wortmannin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of AKT1 protein]; wortmannin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of AKT1 protein]; wortmannin inhibits the reaction [zinc chloride results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of AKT1 protein]; wortmannin promotes the reaction [Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]]; wortmannin promotes the reaction [resveratrol results in decreased phosphorylation of AKT1 protein]; wortmannin promotes the reaction [Thimerosal results in decreased phosphorylation of AKT1 protein]; wortmannin results in decreased activity of and results in decreased phosphorylation of AKT1 protein
Wortmannin results in decreased phosphorylation of AKT1 protein
wortmannin results in decreased expression of AKT1 protein
Wortmannin inhibits the reaction [1,1-dimethylbutyl-1-deoxy-Delta(9)-THC inhibits the reaction [Magnesium deficiency results in decreased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [astringin results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [chaetoglobosins results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [GRK2 protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [GRN protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [hydroxyflutamide results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [INS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [linsidomine results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [NGF protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Peroxynitrous Acid results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of AKT1 mRNA]]; Wortmannin inhibits the reaction [Resveratrol results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Taurocholic Acid inhibits the reaction [Carbon Tetrachloride results in decreased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [Taurolithocholic Acid results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Thapsigargin results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Tunicamycin results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of AKT1 protein]
wortmannin results in decreased activity of AKT1 protein
CTD PMID:11306697 PMID:11340092 PMID:11788791 PMID:12032135 PMID:12388182 PMID:12482858 PMID:12556562 PMID:12614848 PMID:12640124 PMID:14757120 PMID:15050414 PMID:15177934 PMID:15178407 PMID:15355987 PMID:15608143 PMID:15695173 PMID:15845746 PMID:15849355 PMID:15980035 PMID:16059913 PMID:16116186 PMID:16224792 PMID:16499871 PMID:16682453 PMID:16825486 PMID:16973122 PMID:17129604 PMID:17302912 PMID:17324588 PMID:17346750 PMID:17464197 PMID:17513037 PMID:17520698 PMID:17550345 PMID:17728140 PMID:17962351 PMID:18025287 PMID:18040759 PMID:18201823 PMID:18317400 PMID:18591783 PMID:18948619 PMID:19139269 PMID:19686714 PMID:19801633 PMID:19810018 PMID:20005289 PMID:20100827 PMID:20153296 PMID:20562903 PMID:20880397 PMID:21138475 PMID:21195169 PMID:21742513 PMID:21767602 PMID:21820214 PMID:22022464 PMID:22137261 PMID:22556157 PMID:23001822 PMID:23145070 PMID:23178381 PMID:24024143 PMID:24462917 PMID:24748653 PMID:25002221 PMID:25398788 PMID:25461906 PMID:25603053 PMID:25663935 PMID:26262998 PMID:26437446 PMID:28759639 PMID:30542433 PMID:30590302 PMID:30851366 PMID:31173752 PMID:31300867 PMID:31445927 PMID:32805344 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt1s1 AKT1 substrate 1 multiple interactions
decreases phosphorylation
ISO wortmannin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1S1 protein]
wortmannin results in decreased phosphorylation of AKT1S1 protein
CTD PMID:20880397 NCBI chr 1:100,845,443...100,851,961
Ensembl chr 1:100,845,563...100,851,960
JBrowse link
G Alpi alkaline phosphatase, intestinal multiple interactions
increases activity
ISO wortmannin promotes the reaction [Methotrexate results in increased activity of ALPI protein]
wortmannin results in increased activity of ALPI protein
CTD PMID:16598758 NCBI chr 9:94,197,616...94,201,910
Ensembl chr 9:94,197,618...94,201,084
JBrowse link
G Apob apolipoprotein B multiple interactions EXP wortmannin inhibits the reaction [[bisphenol A results in decreased expression of APOB mRNA] which results in decreased abundance of Triglycerides]; wortmannin inhibits the reaction [bisphenol A results in decreased expression of APOB mRNA] CTD PMID:23399309 NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997
JBrowse link
G Areg amphiregulin decreases activity EXP wortmannin results in decreased activity of AREG protein CTD PMID:12589827 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions EXP wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of ARNT mRNA]]; wortmannin inhibits the reaction [INS1 protein results in decreased expression of ARNT mRNA] CTD PMID:26466350 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions EXP Wortmannin inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased phosphorylation of ATF2 protein] CTD PMID:10611455 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO wortmannin inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of TP53 protein]]; wortmannin inhibits the reaction [Mustard Gas results in increased phosphorylation of ATM protein]
ATM protein affects the susceptibility to [wortmannin co-treated with Benzo(a)pyrene]
CTD PMID:15489221 PMID:20888899 PMID:22119920 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
decreases phosphorylation
ISO
EXP
wortmannin inhibits the reaction [Acrolein results in increased phosphorylation of BAD protein]; wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of BAD protein]
wortmannin results in decreased phosphorylation of BAD protein
Wortmannin inhibits the reaction [Mannitol results in increased phosphorylation of BAD protein]; Wortmannin inhibits the reaction [ursodoxicoltaurine results in increased phosphorylation of and affects the localization of BAD protein]
CTD PMID:15190125 PMID:15608143 PMID:15786717 PMID:19596284 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP
Wortmannin inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]]; Wortmannin inhibits the reaction [Leukotriene B4 results in increased expression of BAX protein]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]]
Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in increased expression of BAX protein]]
CTD PMID:15142122 PMID:15970427 PMID:31173752 PMID:32805344 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member multiple interactions ISO [oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]; Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]]; wortmannin inhibits the reaction [oxotremorine M results in increased phosphorylation of BCAR1 protein] CTD PMID:10537051 NCBI chr19:43,932,543...43,967,452
Ensembl chr19:43,932,554...43,955,783
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP
Wortmannin inhibits the reaction [[Hydrogen Peroxide co-treated with Arsenic Trioxide] results in decreased expression of BCL2 protein]; Wortmannin inhibits the reaction [Ethanol results in increased expression of BCL2 protein]; Wortmannin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of BCL2 protein]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]]
Wortmannin inhibits the reaction [[1,1-dimethylbutyl-1-deoxy-Delta(9)-THC co-treated with Magnesium deficiency] results in increased expression of BCL2 protein]; Wortmannin inhibits the reaction [Propofol results in increased expression of BCL2 protein]
CTD PMID:15142122 PMID:19703415 PMID:21410490 PMID:30542433 PMID:31173752 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO wortmannin inhibits the reaction [Hydrogen Peroxide inhibits the reaction [arsenic trioxide results in decreased expression of BCL2L1 protein]] CTD PMID:15142122 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO
EXP
wortmannin inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein]
Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of BDNF protein]]
CTD PMID:17209049 PMID:32805344 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Becn1 beclin 1 multiple interactions
decreases expression
ISO
EXP
wortmannin promotes the reaction [Ethanol results in increased degradation of BECN1 protein]
wortmannin inhibits the reaction [manganese chloride results in increased expression of BECN1 protein]
wortmannin results in decreased expression of BECN1 protein
CTD PMID:21410490 PMID:23604964 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions
decreases expression
ISO wortmannin inhibits the reaction [Acrolein results in increased expression of BIRC2 protein]
wortmannin results in decreased expression of BIRC2 mRNA; wortmannin results in decreased expression of BIRC2 protein
CTD PMID:15065019 PMID:19596284 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO wortmannin inhibits the reaction [Acrolein results in increased expression of BIRC3 protein] CTD PMID:19596284 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression
multiple interactions
ISO wortmannin results in decreased expression of BIRC5 mRNA; wortmannin results in decreased expression of BIRC5 protein
wortmannin promotes the reaction [baicalein results in decreased expression of BIRC5 protein]
wortmannin promotes the reaction [resveratrol results in decreased expression of BIRC5 protein]
CTD PMID:15065019 PMID:18025287 PMID:22137261 PMID:23145070 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G C5 complement C5 multiple interactions ISO wortmannin inhibits the reaction [C5 protein results in decreased expression of [IL12A protein binds to IL12B protein]]; wortmannin inhibits the reaction [C5 protein results in decreased expression of IL12A mRNA]; wortmannin inhibits the reaction [C5 protein results in decreased expression of IL12B mRNA]; wortmannin inhibits the reaction [C5 protein results in decreased expression of IL23A mRNA]; wortmannin inhibits the reaction [C5 protein results in increased phosphorylation of AKT1 protein] CTD PMID:16116186 NCBI chr 3:14,049,993...14,113,931
NCBI chr 3:14,206,466...14,229,141
Ensembl chr 3:14,049,995...14,229,080
JBrowse link
G Casp1 caspase 1 increases cleavage ISO wortmannin results in increased cleavage of CASP1 protein CTD PMID:26847702 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
decreases activity
ISO
EXP
ABT-737 promotes the reaction [Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]]; Wortmannin inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]]; Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]; Wortmannin promotes the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP3 protein]; Wortmannin promotes the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP3 protein]; Wortmannin promotes the reaction [ochratoxin A results in increased activity of CASP3 protein]
wortmannin results in increased cleavage of CASP3 protein
[Rotenone co-treated with wortmannin] results in increased cleavage of CASP3 protein; Thimerosal promotes the reaction [wortmannin results in increased cleavage of CASP3 protein]; wortmannin promotes the reaction [resveratrol results in increased cleavage of CASP3 protein]; wortmannin promotes the reaction [Thimerosal results in increased cleavage of CASP3 protein]; wortmannin promotes the reaction [wortmannin results in increased cleavage of CASP3 protein]
wortmannin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of CASP3 protein]
wortmannin results in decreased activity of CASP3 protein
CTD PMID:15142122 PMID:15695173 PMID:17935137 PMID:20104024 PMID:21256120 PMID:22137261 PMID:23145070 PMID:24726520 PMID:25002221 PMID:25603053 PMID:26847702 PMID:31173752 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO wortmannin promotes the reaction [ochratoxin A results in increased activity of CASP7 protein] CTD PMID:25002221 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions ISO
EXP
ABT-737 promotes the reaction [wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]]; wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]
wortmannin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of CASP8 protein]
CTD PMID:20104024 PMID:24726520 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
ISO
EXP
ABT-737 promotes the reaction [Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]]; Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]; Wortmannin promotes the reaction [Doxorubicin results in increased cleavage of CASP9 protein]; Wortmannin promotes the reaction [Etoposide results in increased cleavage of CASP9 protein]
wortmannin results in increased cleavage of CASP9 protein
Thimerosal promotes the reaction [wortmannin results in increased cleavage of CASP9 protein]; wortmannin promotes the reaction [Thimerosal results in increased cleavage of CASP9 protein]
wortmannin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of CASP9 protein]
CTD PMID:17935137 PMID:20104024 PMID:22137261 PMID:23145070 PMID:24726520 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cav1 caveolin 1 multiple interactions ISO wortmannin inhibits the reaction [CAV1 protein results in increased susceptibility to Hydrogen Peroxide]; wortmannin inhibits the reaction [CAV1 protein results in increased susceptibility to sodium arsenite] CTD PMID:12640124 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA] CTD PMID:22225513 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO wortmannin inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide]; wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 mRNA] CTD PMID:19016906 PMID:22225513 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccna2 cyclin A2 multiple interactions ISO wortmannin inhibits the reaction [Vanadates results in increased expression of CCNA2 protein] CTD PMID:14971663 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [Cadmium Chloride results in increased expression of CCNB1 protein]; [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [EGF protein results in increased expression of CCNB1 protein] CTD PMID:26385184 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO
EXP
wortmannin inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CCND1 mRNA]; wortmannin inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CCND1 protein]
Wortmannin inhibits the reaction [1,1-dimethylbutyl-1-deoxy-Delta(9)-THC inhibits the reaction [Magnesium deficiency results in decreased expression of CCND1 protein]]
wortmannin results in decreased expression of CCND1 protein
CTD PMID:15695173 PMID:19801633 PMID:28321046 PMID:30542433 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd2 cyclin D2 decreases methylation
increases expression
ISO wortmannin results in decreased methylation of CCND2 promoter
wortmannin results in increased expression of CCND2 mRNA
CTD PMID:14745455 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Ccnd3 cyclin D3 affects localization
multiple interactions
ISO wortmannin affects the localization of CCND3 protein
[wortmannin co-treated with Imatinib Mesylate] affects the localization of CCND3 protein; wortmannin inhibits the reaction [KITL protein results in increased expression of CCND3 protein]
CTD PMID:10849422 PMID:17129604 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO wortmannin inhibits the reaction [Vanadates results in increased expression of CCNE1 protein]
[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [Cadmium Chloride results in increased expression of CCNE1 protein]; [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [EGF protein results in increased expression of CCNE1 protein]
CTD PMID:14971663 PMID:26385184 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccr3 C-C motif chemokine receptor 3 multiple interactions ISO wortmannin inhibits the reaction [IL3 protein results in decreased expression of CCR3 protein] CTD PMID:11544337 NCBI chr 8:133,026,539...133,040,999
Ensembl chr 8:133,029,625...133,040,997
JBrowse link
G Ccr5 C-C motif chemokine receptor 5 multiple interactions ISO wortmannin inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide] CTD PMID:19016906 NCBI chr 8:133,192,398...133,215,599
Ensembl chr 8:133,197,032...133,215,614
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO wortmannin inhibits the reaction [Oxygen deficiency results in increased expression of CD36 mRNA] CTD PMID:19640849 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cdc25a cell division cycle 25A multiple interactions
decreases expression
ISO Imatinib Mesylate promotes the reaction [wortmannin results in decreased expression of CDC25A protein] CTD PMID:17129604 NCBI chr 8:117,953,223...117,971,552
Ensembl chr 8:117,953,444...117,971,519
JBrowse link
G Cdc5l cell division cycle 5-like multiple interactions EXP wortmannin inhibits the reaction [NGF protein promotes the reaction [YWHAB protein binds to CDC5L protein]] CTD PMID:20629186 NCBI chr 9:17,949,764...17,988,514
Ensembl chr 9:17,949,764...17,988,509
JBrowse link
G Cdh1 cadherin 1 increases expression ISO wortmannin results in increased expression of CDH1 protein CTD PMID:25856345 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO Wortmannin inhibits the reaction [hydroxyflutamide results in decreased phosphorylation of CDH2 protein]; Wortmannin inhibits the reaction [Testosterone results in decreased phosphorylation of CDH2 protein] CTD PMID:28163245 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [Cadmium Chloride results in increased expression of CDK1 protein]; [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [EGF protein results in increased expression of CDK1 protein]; wortmannin promotes the reaction [baicalein results in decreased phosphorylation of CDK1 protein] CTD PMID:18025287 PMID:26385184 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases activity
multiple interactions
decreases expression
ISO wortmannin results in decreased activity of CDK2 protein
[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [Cadmium Chloride results in increased expression of CDK2 protein]; [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [EGF protein results in increased expression of CDK2 protein]
wortmannin results in decreased expression of CDK2 protein
CTD PMID:17129604 PMID:26385184 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
decreases expression
increases expression
ISO wortmannin inhibits the reaction [Aspirin results in increased expression of CDKN1A protein]; wortmannin inhibits the reaction [docetaxel results in increased expression of CDKN1A protein]
wortmannin results in decreased expression of CDKN1A protein
wortmannin results in increased expression of CDKN1A protein
CTD PMID:15695173 PMID:17129604 PMID:20878124 PMID:21617849 PMID:22290291 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions
increases expression
ISO wortmannin promotes the reaction [Doxorubicin results in increased expression of CDKN1B protein]; wortmannin promotes the reaction [Etoposide results in increased expression of CDKN1B protein]
Imatinib Mesylate promotes the reaction [wortmannin results in increased expression of CDKN1B protein]
CTD PMID:17129604 PMID:17935137 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO wortmannin inhibits the reaction [CGP 12177 results in increased activity of CFTR protein] CTD PMID:15563584 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions
decreases expression
ISO wortmannin inhibits the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein]; wortmannin inhibits the reaction [Mustard Gas results in increased phosphorylation of CHEK1 protein]
wortmannin results in decreased expression of CHEK1 protein
CTD PMID:19261750 PMID:22119920 PMID:22409540 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions
decreases phosphorylation
ISO wortmannin inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of CHEK2 protein]; wortmannin inhibits the reaction [Mustard Gas results in increased phosphorylation of CHEK2 protein]
wortmannin results in decreased phosphorylation of CHEK2 protein
CTD PMID:19111594 PMID:22119920 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Clu clusterin multiple interactions ISO wortmannin inhibits the reaction [Zinc results in increased expression of CLU protein] CTD PMID:19288494 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain multiple interactions ISO wortmannin inhibits the reaction [cobaltous chloride results in decreased expression of COL18A1 mRNA]; wortmannin inhibits the reaction [cobaltous chloride results in decreased expression of COL18A1 protein] CTD PMID:13679210 NCBI chr20:12,225,202...12,332,858
Ensembl chr20:12,225,202...12,332,858
JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions ISO wortmannin inhibits the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA] CTD PMID:11343241 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions EXP wortmannin inhibits the reaction [bisphenol A results in decreased expression of CPT1A mRNA] CTD PMID:23399309 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in increased phosphorylation of CREB1 protein]; wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of CREB1 protein]
wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CREB1 protein]]
CTD PMID:15608143 PMID:22952890 PMID:23626723 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crp C-reactive protein multiple interactions ISO wortmannin inhibits the reaction [Dust analog results in increased expression of CRP mRNA]; wortmannin inhibits the reaction [Dust results in increased expression of CRP mRNA]; wortmannin inhibits the reaction [Particulate Matter analog results in increased expression of CRP mRNA]; wortmannin inhibits the reaction [Particulate Matter results in increased expression of CRP mRNA]; wortmannin inhibits the reaction [Vehicle Emissions analog results in increased expression of CRP mRNA]; wortmannin inhibits the reaction [Vehicle Emissions results in increased expression of CRP mRNA] CTD PMID:16263508 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased expression of LAT2 protein]; wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of RPS6 protein] CTD PMID:23001822 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Ctnnb1 catenin beta 1 decreases expression
increases phosphorylation
multiple interactions
ISO wortmannin results in decreased expression of CTNNB1 protein
wortmannin results in increased phosphorylation of CTNNB1 protein
wortmannin inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CTNNB1 protein]; wortmannin inhibits the reaction [hydroxyflutamide results in decreased phosphorylation of CTNNB1 protein]; wortmannin inhibits the reaction [Testosterone results in decreased phosphorylation of CTNNB1 protein]
CTD PMID:11739494 PMID:28163245 PMID:28321046 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP wortmannin inhibits the reaction [resveratrol results in decreased activity of CXCL1 protein] CTD PMID:20117814 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO
EXP
wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of BAD protein]; wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of CREB1 protein]
wortmannin inhibits the reaction [resveratrol results in decreased activity of CXCL2 protein]
CTD PMID:15608143 PMID:20117814 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 multiple interactions ISO wortmannin inhibits the reaction [CXCL8 protein results in increased activity of CXCR2 protein] CTD PMID:12975484 NCBI chr 9:81,427,275...81,435,065
Ensembl chr 9:81,427,730...81,434,102
JBrowse link
G Cycs cytochrome c, somatic decreases secretion EXP wortmannin results in decreased secretion of CYCS protein CTD PMID:21256120 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions EXP wortmannin inhibits the reaction [Atrazine promotes the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]]; wortmannin inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA] CTD PMID:25253736 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP
ISO
wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]]; wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP1A1 mRNA]
[Filipin co-treated with Chlorpromazine co-treated with Wortmannin] inhibits the reaction [Particulate Matter results in increased expression of CYP1A1 mRNA]
CTD PMID:26466350 PMID:29724254 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]]; wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP1A2 mRNA] CTD PMID:26466350 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions EXP
ISO
wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP1B1 mRNA]
[Filipin co-treated with Chlorpromazine co-treated with Wortmannin] inhibits the reaction [Particulate Matter results in increased expression of CYP1B1 mRNA]
CTD PMID:26466350 PMID:29724254 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP
ISO
wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP2E1 mRNA]
Wortmannin inhibits the reaction [Arachidonic Acid promotes the reaction [CYP2E1 protein results in increased expression of KLF6 mRNA]]; Wortmannin inhibits the reaction [CYP2E1 protein results in increased expression of KLF6 mRNA]
CTD PMID:11306697 PMID:22486562 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO wortmannin inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; wortmannin inhibits the reaction [Curcumin results in increased expression of DDIT3 protein] CTD PMID:17171638 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 multiple interactions ISO wortmannin inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of DKK1 mRNA] CTD PMID:28321046 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
Ensembl chr 1:248,895,738...248,898,607
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha multiple interactions ISO wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3A protein] CTD PMID:23626723 NCBI chr 6:28,205,375...28,346,052
Ensembl chr 6:28,235,695...28,340,577
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta multiple interactions ISO wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3B protein] CTD PMID:23626723 NCBI chr 3:149,131,541...149,170,061
Ensembl chr 3:149,131,785...149,208,786
JBrowse link
G Dnmt3l DNA methyltransferase 3 like multiple interactions ISO wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3L protein] CTD PMID:23626723 NCBI chr20:11,344,513...11,359,090
Ensembl chr20:11,344,514...11,359,090
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO wortmannin inhibits the reaction [Vanadates results in increased expression of E2F1 protein] CTD PMID:14971663 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO wortmannin inhibits the reaction [EDN1 protein inhibits the reaction [TNF protein results in increased expression of NOS2 protein]] CTD PMID:12839867 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Egf epidermal growth factor multiple interactions ISO
EXP
[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with Wortmannin] inhibits the reaction [EGF protein results in increased expression of CCNB1 protein]; [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with Wortmannin] inhibits the reaction [EGF protein results in increased expression of CCNE1 protein]; [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with Wortmannin] inhibits the reaction [EGF protein results in increased expression of CDK1 protein]; [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with Wortmannin] inhibits the reaction [EGF protein results in increased expression of CDK2 protein]; Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of SRC protein]
Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [EGF protein results in increased uptake of Fructose]
CTD PMID:15691865 PMID:15849355 PMID:25856345 PMID:26385184 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]
wortmannin inhibits the reaction [Sodium Chloride results in increased phosphorylation of EGFR protein]
CTD PMID:15177934 PMID:21568938 PMID:25856345 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO wortmannin inhibits the reaction [IGF1 protein results in increased phosphorylation of EIF4EBP1 protein]; wortmannin inhibits the reaction [INS protein results in increased expression of EIF4EBP1 protein modified form] CTD PMID:12569580 PMID:20936651 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Epor erythropoietin receptor multiple interactions ISO wortmannin inhibits the reaction [testosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in increased expression of EPOR mRNA] CTD PMID:20189893 NCBI chr 8:22,969,737...22,974,468
Ensembl chr 8:22,969,745...22,974,321
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO wortmannin promotes the reaction [Histamine results in increased expression of F3] CTD PMID:16009787 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fas Fas cell surface death receptor affects response to substance ISO Wortmannin affects the susceptibility to FAS protein CTD PMID:31445927 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand multiple interactions ISO wortmannin inhibits the reaction [evodiamine results in increased expression of FASLG protein] CTD PMID:20005289 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fgf1 fibroblast growth factor 1 decreases activity
multiple interactions
ISO
EXP
wortmannin results in decreased activity of FGF1 protein
wortmannin inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA]
CTD PMID:15121739 PMID:15695173 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Fgf7 fibroblast growth factor 7 multiple interactions ISO wortmannin inhibits the reaction [FGF7 protein results in increased expression of PLAC1 mRNA] CTD PMID:15803460 NCBI chr 3:118,315,859...118,368,464
Ensembl chr 3:118,317,761...118,366,872
JBrowse link
G Flna filamin A multiple interactions ISO wortmannin inhibits the reaction [arsenic trichloride results in increased phosphorylation of FLNA protein] CTD PMID:25944616 NCBI chr  X:156,460,785...156,487,245
Ensembl chr  X:156,463,953...156,487,245
JBrowse link
G Flt3lg Fms related receptor tyrosine kinase 3 ligand multiple interactions ISO wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased expression of LAT2 protein]; wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of RPS6 protein] CTD PMID:23001822 NCBI chr 1:101,126,006...101,131,413
Ensembl chr 1:101,124,479...101,131,413
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP
ISO
wortmannin inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of FOS mRNA]
Wortmannin inhibits the reaction [Dieldrin results in increased expression of FOS mRNA]
CTD PMID:11687581 PMID:31068361 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO wortmannin inhibits the reaction [arsenite results in increased phosphorylation of FOXO1 protein]; wortmannin inhibits the reaction [Copper affects the localization of FOXO1 protein]; wortmannin inhibits the reaction [Copper results in increased phosphorylation of FOXO1 protein]; wortmannin inhibits the reaction [Copper Sulfate affects the localization of FOXO1 protein]; wortmannin inhibits the reaction [Copper Sulfate results in increased phosphorylation of FOXO1 protein]; wortmannin inhibits the reaction [Doxorubicin results in increased phosphorylation of FOXO1 protein]; wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of FOXO1 protein]; wortmannin inhibits the reaction [INS protein results in increased expression of FOXO1 protein modified form]; wortmannin inhibits the reaction [Zinc affects the localization of FOXO1 protein]; wortmannin inhibits the reaction [Zinc results in increased phosphorylation of FOXO1 protein]; wortmannin inhibits the reaction [Zinc Sulfate affects the localization of FOXO1 protein]; wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of FOXO1 protein] CTD PMID:16973122 PMID:17935137 PMID:20936651 PMID:24024143 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Foxo3 forkhead box O3 multiple interactions
decreases phosphorylation
ISO Wortmannin inhibits the reaction [arsenite results in increased phosphorylation of FOXO3 protein]; Wortmannin inhibits the reaction [Cadmium Chloride results in decreased activity of FOXO3 protein]; Wortmannin inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein]; Wortmannin inhibits the reaction [Doxorubicin results in increased phosphorylation of FOXO3 protein]; Wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of FOXO3 protein]; Wortmannin inhibits the reaction [INS protein results in increased expression of FOXO3 protein modified form]
wortmannin results in decreased phosphorylation of FOXO3 protein
CTD PMID:17935137 PMID:20936651 PMID:23673518 PMID:24024143 PMID:25856345 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Foxo4 forkhead box O4 multiple interactions ISO wortmannin inhibits the reaction [Copper results in increased phosphorylation of FOXO4 protein]; wortmannin inhibits the reaction [Copper Sulfate results in increased phosphorylation of FOXO4 protein]; wortmannin inhibits the reaction [Zinc results in increased phosphorylation of FOXO4 protein]; wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of FOXO4 protein] CTD PMID:16973122 NCBI chr  X:71,155,284...71,162,158
Ensembl chr  X:71,155,601...71,162,158
JBrowse link
G Foxp1 forkhead box P1 decreases expression ISO wortmannin results in decreased expression of FOXP1 protein CTD PMID:25663935 NCBI chr 4:131,362,178...131,963,466
Ensembl chr 4:131,366,744...131,694,755
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP wortmannin inhibits the reaction [Atrazine promotes the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]]; wortmannin inhibits the reaction [Atrazine promotes the reaction [FSHB protein results in increased expression of STAR mRNA]]; wortmannin inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]; wortmannin inhibits the reaction [FSHB protein results in increased expression of STAR mRNA] CTD PMID:25253736 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions ISO wortmannin inhibits the reaction [2-tert-butylhydroquinone results in increased expression of FTH1 mRNA] CTD PMID:23829535 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 increases expression
multiple interactions
ISO Wortmannin results in increased expression of G6PC1 mRNA
Wortmannin inhibits the reaction [INS protein results in decreased expression of G6PC1 mRNA]
CTD PMID:24535192 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Gast gastrin decreases secretion EXP wortmannin results in decreased secretion of GAST protein CTD PMID:19208342 NCBI chr10:88,245,532...88,248,485
Ensembl chr10:88,245,532...88,248,484
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO wortmannin results in increased expression of GDF15 protein CTD PMID:23178381 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP wortmannin inhibits the reaction [hydroxyflutamide results in decreased expression of GJA1 protein] CTD PMID:26437446 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Glp1r glucagon-like peptide 1 receptor multiple interactions EXP wortmannin inhibits the reaction [Oleic Acid results in increased degradation of and results in decreased expression of GLP1R protein] CTD PMID:22925809 NCBI chr20:9,586,075...9,626,228
Ensembl chr20:9,586,075...9,626,228
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 multiple interactions EXP wortmannin inhibits the reaction [GRK2 protein results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [GRK2 protein results in increased phosphorylation of GSK3B protein]; wortmannin promotes the reaction [GRK2 protein promotes the reaction [GRK2 protein binds to PIK3CG protein]] CTD PMID:28759639 NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328
JBrowse link
G Grn granulin precursor multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [wortmannin inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]]; U 0126 promotes the reaction [wortmannin inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]]; wortmannin inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]; wortmannin inhibits the reaction [GRN protein results in increased phosphorylation of AKT1 protein] CTD PMID:21820214 NCBI chr10:90,377,103...90,383,207
Ensembl chr10:90,376,933...90,383,205
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
decreases phosphorylation
decreases expression
ISO
EXP
Wortmannin inhibits the reaction [Bortezomib results in decreased activity of and results in increased phosphorylation of GSK3B protein]; Wortmannin inhibits the reaction [Estradiol results in increased phosphorylation of GSK3B protein]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of GSK3B protein]]; Wortmannin inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of GSK3B protein]; Wortmannin inhibits the reaction [Zinc results in increased phosphorylation of GSK3B protein]
wortmannin results in decreased phosphorylation of GSK3B protein
wortmannin inhibits the reaction [chaetoglobosins results in increased phosphorylation of GSK3B protein]; wortmannin inhibits the reaction [GRK2 protein results in increased phosphorylation of GSK3B protein]; wortmannin inhibits the reaction [rosiglitazone results in increased phosphorylation of GSK3B protein]
wortmannin results in decreased expression of GSK3B protein modified form
Melatonin inhibits the reaction [wortmannin results in decreased expression of GSK3B protein modified form]; Vitamin E inhibits the reaction [wortmannin results in decreased expression of GSK3B protein modified form]; wortmannin inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of GSK3B protein modified form]]
CTD PMID:12614848 PMID:15842767 PMID:16076840 PMID:17513037 PMID:18040759 PMID:19566839 PMID:20090934 PMID:23170834 PMID:23178381 PMID:24085292 PMID:28759639 PMID:31173752 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO Wortmannin inhibits the reaction [Decitabine results in increased expression of H2AX protein]; Wortmannin promotes the reaction [Docetaxel results in increased expression of H2AX protein]; Wortmannin promotes the reaction [Soil Pollutants results in increased phosphorylation of H2AX protein] CTD PMID:17991895 PMID:20878124 PMID:22409540 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression
ISO [wortmannin co-treated with U 0126] inhibits the reaction [IGF1 protein promotes the reaction [cobaltous chloride results in increased expression of HIF1A protein]]; wortmannin inhibits the reaction [4-hydroxyestradiol results in increased expression of HIF1A protein]; wortmannin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein]; wortmannin inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; wortmannin inhibits the reaction [CR 3294 results in decreased expression of HIF1A protein]; wortmannin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]; wortmannin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; wortmannin inhibits the reaction [sodium arsenite results in increased expression of HIF1A protein]
wortmannin results in decreased expression of HIF1A protein
CTD PMID:11424089 PMID:13679210 PMID:14726529 PMID:15050414 PMID:16499871 PMID:18927491 PMID:19640849 PMID:20153296 PMID:20335389 PMID:23968725 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO wortmannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of and affects the localization of HMGB1 protein] CTD PMID:19265175 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO
EXP
wortmannin inhibits the reaction [10-nitro-oleic acid results in increased expression of HMOX1 protein]; wortmannin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; wortmannin inhibits the reaction [Acrolein results in increased expression of HMOX1 mRNA]; wortmannin inhibits the reaction [plumbagin results in increased expression of HMOX1 protein]
Wortmannin inhibits the reaction [astringin results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [naringenin results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [Quercetin results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [Resveratrol results in increased expression of HMOX1 protein]
wortmannin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; wortmannin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; wortmannin inhibits the reaction [bis(4-hydroxycinnamoyl)methane results in increased expression of HMOX1 mRNA]; wortmannin inhibits the reaction [bis(4-hydroxycinnamoyl)methane results in increased expression of HMOX1 protein]; wortmannin inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; wortmannin inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; wortmannin inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]; wortmannin inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 protein]
CTD PMID:17535857 PMID:18048804 PMID:20028456 PMID:20117814 PMID:22022464 PMID:22056766 PMID:22709785 PMID:23845594 PMID:24423726 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsf1 heat shock transcription factor 1 affects localization
multiple interactions
ISO wortmannin affects the localization of HSF1 protein
wortmannin inhibits the reaction [Oxygen deficiency results in increased expression of HSF1 mRNA]
CTD PMID:11424089 PMID:20090934 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A decreases expression ISO wortmannin results in decreased expression of HSPA1A protein; wortmannin results in decreased expression of HSPA1A protein alternative form CTD PMID:20090934 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO wortmannin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 mRNA] CTD PMID:19428936 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP
ISO
wortmannin inhibits the reaction [resveratrol results in decreased activity of ICAM1 protein]
wortmannin inhibits the reaction [Norepinephrine promotes the reaction [REL protein binds to ICAM1 promoter]]
CTD PMID:20117814 PMID:23114885 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO wortmannin inhibits the reaction [[Vehicle Emissions analog co-treated with Poly I-C] results in increased expression of IFNB1 mRNA] CTD PMID:16399790 NCBI chr 5:106,865,192...106,865,746
Ensembl chr 5:106,865,192...106,865,746
JBrowse link
G Ifng interferon gamma multiple interactions ISO wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]; wortmannin promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] CTD PMID:16968468 PMID:25352548 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO
EXP
[wortmannin co-treated with U 0126] inhibits the reaction [IGF1 protein promotes the reaction [cobaltous chloride results in increased expression of HIF1A protein]]; wortmannin inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein]; wortmannin inhibits the reaction [IGF1 protein results in increased activity of MAPK1 protein]; wortmannin inhibits the reaction [IGF1 protein results in increased activity of MAPK3 protein]; wortmannin inhibits the reaction [IGF1 protein results in increased activity of MTR protein]; wortmannin inhibits the reaction [IGF1 protein results in increased expression of MYCN protein]; wortmannin inhibits the reaction [IGF1 protein results in increased expression of ZNF143 protein]; wortmannin inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [IGF1 protein results in increased phosphorylation of EIF4EBP1 protein]; wortmannin inhibits the reaction [IGF1 protein results in increased secretion of VEGFA protein]
Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of IGF1 protein]]
wortmannin inhibits the reaction [IGF1 protein results in increased expression of MYH4 mRNA]
CTD PMID:12569580 PMID:14745455 PMID:16499871 PMID:16682453 PMID:17520698 PMID:19657059 PMID:20733350 PMID:32805344 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igf2 insulin-like growth factor 2 decreases response to substance
multiple interactions
ISO wortmannin results in decreased susceptibility to IGF2 protein
wortmannin inhibits the reaction [IGF2 protein results in increased expression of STS mRNA]
CTD PMID:24055520 NCBI chr 1:215,828,102...215,839,081
Ensembl chr 1:215,828,102...215,846,911
JBrowse link
G Il12a interleukin 12A multiple interactions ISO Wortmannin inhibits the reaction [C5 protein results in decreased expression of [IL12A protein binds to IL12B protein]]; Wortmannin inhibits the reaction [C5 protein results in decreased expression of IL12A mRNA]; Wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]] CTD PMID:16116186 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
JBrowse link
G Il12b interleukin 12B multiple interactions ISO wortmannin inhibits the reaction [C5 protein results in decreased expression of [IL12A protein binds to IL12B protein]]; wortmannin inhibits the reaction [C5 protein results in decreased expression of IL12B mRNA]; wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]] CTD PMID:16116186 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il17a interleukin 17A multiple interactions ISO wortmannin inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA] CTD PMID:17982072 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il18 interleukin 18 multiple interactions ISO wortmannin inhibits the reaction [Isoproterenol results in increased secretion of IL18 protein] CTD PMID:15178407 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]] CTD PMID:16968468 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO wortmannin inhibits the reaction [IL1B protein results in increased activity of MMP12 protein]; wortmannin inhibits the reaction [IL1B protein results in increased expression of MMP12 mRNA]; wortmannin promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]
Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL1B protein]]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]
CTD PMID:16359550 PMID:22952890 PMID:25352548 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rn interleukin 1 receptor antagonist decreases expression ISO wortmannin results in decreased expression of IL1RN mRNA CTD PMID:26847702 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il23a interleukin 23 subunit alpha multiple interactions ISO wortmannin inhibits the reaction [C5 protein results in decreased expression of IL23A mRNA] CTD PMID:16116186 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
JBrowse link
G Il3 interleukin 3 multiple interactions ISO Wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased expression of LAT2 protein]; Wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of RPS6 protein]; Wortmannin inhibits the reaction [IL3 protein results in decreased expression of CCR3 protein] CTD PMID:11544337 PMID:23001822 NCBI chr10:39,620,535...39,622,973
Ensembl chr10:39,620,563...39,622,973
JBrowse link
G Il4 interleukin 4 multiple interactions EXP Wortmannin inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased expression of and results in increased secretion of IL4 protein]; Wortmannin inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased expression of IL4 mRNA] CTD PMID:10611455 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO
wortmannin inhibits the reaction [resveratrol results in decreased activity of IL6 protein]
[4'-hydroxywogonin co-treated with Wortmannin] inhibits the reaction [IL6 protein results in increased expression of and results in increased secretion of VEGFA protein]; [4'-hydroxywogonin co-treated with Wortmannin] inhibits the reaction [IL6 protein results in increased expression of VEGFA mRNA]; Wortmannin inhibits the reaction [IL6 protein results in increased expression of and results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [IL6 protein results in increased expression of VEGFA mRNA]
wortmannin inhibits the reaction [di-n-butyltin results in increased expression of IL6 mRNA]; wortmannin inhibits the reaction [di-n-butyltin results in increased expression of IL6 protein]
CTD PMID:20117814 PMID:24631921 PMID:30217479 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 multiple interactions ISO
EXP
[Wortmannin co-treated with INS protein] inhibits the reaction [Glucose affects the localization of PDX1 protein]; Wortmannin inhibits the reaction [INS protein results in decreased expression of G6PC1 mRNA]; Wortmannin inhibits the reaction [INS protein results in decreased susceptibility to Coumaric Acids]; Wortmannin inhibits the reaction [INS protein results in increased expression of EIF4EBP1 protein modified form]; Wortmannin inhibits the reaction [INS protein results in increased expression of FOXO1 protein modified form]; Wortmannin inhibits the reaction [INS protein results in increased expression of FOXO3 protein modified form]; Wortmannin inhibits the reaction [INS protein results in increased expression of IRS1 protein modified form]; Wortmannin inhibits the reaction [INS protein results in increased expression of MAPK1 protein modified form]; Wortmannin inhibits the reaction [INS protein results in increased expression of MAPK3 protein modified form]; Wortmannin inhibits the reaction [INS protein results in increased expression of RPS6KB1 protein modified form]; Wortmannin inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]
wortmannin inhibits the reaction [INS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]
CTD PMID:11574405 PMID:17550345 PMID:17728140 PMID:20015842 PMID:20936651 PMID:24535192 PMID:24748653 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Insr insulin receptor multiple interactions EXP Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of INSR mRNA]] CTD PMID:32805344 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 decreases expression ISO wortmannin results in decreased expression of IRAK3 mRNA CTD PMID:26847702 NCBI chr 7:64,922,830...64,982,224
Ensembl chr 7:64,923,615...64,982,281
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO
EXP
wortmannin inhibits the reaction [INS protein results in increased expression of IRS1 protein modified form]
Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of IRS1 mRNA]]
CTD PMID:20936651 PMID:32805344 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Itgav integrin subunit alpha V multiple interactions ISO wortmannin inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]] CTD PMID:15213856 NCBI chr 3:71,113,269...71,205,958
Ensembl chr 3:71,114,100...71,202,411
JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions ISO wortmannin inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein] CTD PMID:16963453 NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647
JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions ISO wortmannin inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]] CTD PMID:15213856 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link
G Kcnh1 potassium voltage-gated channel subfamily H member 1 multiple interactions ISO wortmannin inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein] CTD PMID:17520698 NCBI chr13:110,920,712...111,232,291
Ensembl chr13:110,920,737...111,232,269
JBrowse link
G Kitlg KIT ligand multiple interactions ISO wortmannin inhibits the reaction [KITL protein results in increased expression of CCND3 protein]; wortmannin inhibits the reaction [KITL protein results in increased phosphorylation of RB1 protein]
wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased expression of LAT2 protein]; wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of RPS6 protein]
CTD PMID:10849422 PMID:23001822 NCBI chr 7:42,269,784...42,351,054
Ensembl chr 7:42,269,784...42,351,054
JBrowse link
G Klf4 Kruppel like factor 4 multiple interactions EXP wortmannin inhibits the reaction [Estradiol results in increased expression of KLF4 protein] CTD PMID:21484412 NCBI chr 5:72,283,311...72,287,669
Ensembl chr 5:72,283,313...72,287,669
JBrowse link
G Klf6 Kruppel-like factor 6 decreases expression
multiple interactions
ISO Wortmannin results in decreased expression of KLF6 mRNA
Wortmannin inhibits the reaction [Arachidonic Acid promotes the reaction [CYP2E1 protein results in increased expression of KLF6 mRNA]]; Wortmannin inhibits the reaction [CYP2E1 protein results in increased expression of KLF6 mRNA]
CTD PMID:22486562 NCBI chr17:67,887,939...67,945,052
Ensembl chr17:67,887,939...67,945,037
JBrowse link
G Kng2 kininogen 2 multiple interactions EXP KNG1 protein inhibits the reaction [[Wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]; Wortmannin inhibits the reaction [KNG1 protein results in increased phosphorylation of PTK2 protein] CTD PMID:10537051 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Lat2 linker for activation of T cells family, member 2 multiple interactions ISO wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased expression of LAT2 protein] CTD PMID:23001822 NCBI chr12:25,114,099...25,128,381
Ensembl chr12:25,119,355...25,125,749
JBrowse link
G Lep leptin decreases expression
multiple interactions
decreases secretion
ISO wortmannin results in decreased expression of LEP mRNA
wortmannin inhibits the reaction [LEP protein results in increased transport of Calcium]
wortmannin results in decreased secretion of LEP protein
CTD PMID:19254925 PMID:20107083 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lig1 DNA ligase 1 multiple interactions ISO wortmannin inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of LIG1 protein] CTD PMID:16700562 NCBI chr 1:75,356,212...75,394,757
Ensembl chr 1:75,356,220...75,394,758
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
decreases expression
ISO wortmannin inhibits the reaction [Rotenone results in increased expression of MAP1LC3B protein]
wortmannin results in decreased expression of MAP1LC3B protein
CTD PMID:26847702 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation
ISO
EXP
[bisindolylmaleimide I co-treated with Wortmannin] inhibits the reaction [Zinc results in increased phosphorylation of MAPK1 protein]; KN 93 promotes the reaction [Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK1 protein]]; Wortmannin inhibits the reaction [4,4'-hexafluorisopropylidene diphenol results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [4,4'-thiodiphenol results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [IGF1 protein results in increased activity of MAPK1 protein]; Wortmannin inhibits the reaction [INS protein results in increased expression of MAPK1 protein modified form]; Wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Wortmannin inhibits the reaction [ON123300 results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [Zinc results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK1 protein]; Wortmannin promotes the reaction [KN 93 inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK1 protein]]; Wortmannin promotes the reaction [ochratoxin A results in increased phosphorylation of MAPK1 protein]
Wortmannin inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased activity of MAPK1 protein]
wortmannin results in decreased phosphorylation of MAPK1 protein
wortmannin results in increased phosphorylation of MAPK1 protein
Wortmannin affects the reaction [Ptychodiscus brevis T2 toxin affects the phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [HU 211 results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]]
CTD PMID:10611455 PMID:15086530 PMID:15177934 PMID:15355987 PMID:15608143 PMID:16499871 PMID:18950629 PMID:19139269 PMID:19477951 PMID:20522546 PMID:20936651 PMID:22952890 PMID:24568969 PMID:25002221 PMID:25856345 PMID:27880919 PMID:30590302 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO wortmannin promotes the reaction [Tretinoin results in increased phosphorylation of MAPK14 protein] CTD PMID:12032135 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
increases phosphorylation
ISO
EXP
[bisindolylmaleimide I co-treated with Wortmannin] inhibits the reaction [Zinc results in increased phosphorylation of MAPK3 protein]; KN 93 promotes the reaction [Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK3 protein]]; Wortmannin inhibits the reaction [4,4'-hexafluorisopropylidene diphenol results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [4,4'-thiodiphenol results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [IGF1 protein results in increased activity of MAPK3 protein]; Wortmannin inhibits the reaction [INS protein results in increased expression of MAPK3 protein modified form]; Wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Wortmannin inhibits the reaction [ON123300 results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [Zinc results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK3 protein]; Wortmannin promotes the reaction [KN 93 inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK3 protein]]; Wortmannin promotes the reaction [ochratoxin A results in increased phosphorylation of MAPK3 protein]
Wortmannin inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased activity of MAPK3 protein]
wortmannin results in decreased phosphorylation of MAPK3 protein
wortmannin results in increased phosphorylation of MAPK3 protein
Wortmannin affects the reaction [Ptychodiscus brevis T2 toxin affects the phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [HU 211 results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]]
CTD PMID:10611455 PMID:15086530 PMID:15177934 PMID:15355987 PMID:15608143 PMID:16499871 PMID:18950629 PMID:19139269 PMID:19477951 PMID:20522546 PMID:20936651 PMID:22952890 PMID:24568969 PMID:25002221 PMID:25856345 PMID:27880919 PMID:30590302 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
decreases phosphorylation
ISO
EXP
wortmannin inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased phosphorylation of MAPK8 protein]; wortmannin inhibits the reaction [HU 211 results in increased phosphorylation of MAPK8 protein]
Wortmannin inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased phosphorylation of MAPK8 protein]
wortmannin results in decreased phosphorylation of MAPK8 protein
CTD PMID:10611455 PMID:18950629 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP Wortmannin inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased phosphorylation of MAPK9 protein] CTD PMID:10611455 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions
increases phosphorylation
ISO Melatonin inhibits the reaction [wortmannin results in increased phosphorylation of MAPT protein]; Vitamin E inhibits the reaction [wortmannin results in increased phosphorylation of MAPT protein]
Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPT protein]]
CTD PMID:15842767 PMID:31173752 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
decreases expression
ISO wortmannin inhibits the reaction [Leukotriene B4 results in increased expression of MCL1 protein]; wortmannin promotes the reaction [Doxorubicin results in decreased expression of MCL1 protein]; wortmannin promotes the reaction [Etoposide results in decreased expression of MCL1 protein]
wortmannin results in decreased expression of MCL1 protein
CTD PMID:15970427 PMID:17935137 PMID:23353698 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions ISO wortmannin promotes the reaction [Doxorubicin results in increased phosphorylation of MDM2 protein]; wortmannin promotes the reaction [Etoposide results in increased phosphorylation of MDM2 protein] CTD PMID:17935137 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mir200a microRNA 200a multiple interactions ISO [wortmannin co-treated with Dehydroepiandrosterone] results in increased expression of MIR200A mRNA CTD PMID:25969534 NCBI chr 5:173,489,366...173,489,454 JBrowse link
G Mir21 microRNA 21 multiple interactions ISO wortmannin inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; wortmannin inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA]; wortmannin inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of MIR21 mRNA] CTD PMID:23052036 PMID:25969534 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
JBrowse link
G Mir22 microRNA 22 multiple interactions ISO [wortmannin co-treated with Dehydroepiandrosterone] results in increased expression of MIR22 mRNA CTD PMID:25969534 NCBI chr10:62,299,592...62,299,686
Ensembl chr10:62,299,592...62,299,686
JBrowse link
G Mmp12 matrix metallopeptidase 12 multiple interactions ISO wortmannin inhibits the reaction [IL1B protein results in increased activity of MMP12 protein]; wortmannin inhibits the reaction [IL1B protein results in increased expression of MMP12 mRNA] CTD PMID:16359550 NCBI chr 8:5,594,717...5,616,494
Ensembl chr 8:5,606,592...5,616,493
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression
ISO brazilein promotes the reaction [wortmannin results in decreased expression of and results in decreased activity of MMP2 protein]; wortmannin promotes the reaction [brazilein results in decreased expression of and results in decreased activity of MMP2 protein]; wortmannin results in decreased expression of and results in decreased activity of MMP2 protein
wortmannin results in decreased expression of MMP2
CTD PMID:23707804 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases activity
EXP
ISO
wortmannin inhibits the reaction [Adenosine Triphosphate results in increased activity of MMP9 protein]
wortmannin results in decreased activity of MMP9 protein
wortmannin inhibits the reaction [fucoidan results in decreased expression of MMP9]; wortmannin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein]; wortmannin promotes the reaction [ovatodiolide results in decreased activity of MMP9 protein]
CTD PMID:20195827 PMID:22033475 PMID:23288142 PMID:24333868 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO
EXP
Wortmannin inhibits the reaction [[[MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein] which results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of MPO protein]
wortmannin inhibits the reaction [resveratrol results in decreased activity of MPO protein]
CTD PMID:18987595 PMID:20117814 PMID:26262998 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Ms4a2 membrane spanning 4-domains A2 multiple interactions
decreases response to substance
ISO MS4A2 protein mutant form inhibits the reaction [wortmannin inhibits the reaction [Antigens results in increased abundance of Hydrogen Peroxide]]
MS4A2 protein mutant form results in decreased susceptibility to wortmannin
CTD PMID:19467708 NCBI chr 1:227,957,363...227,965,312
Ensembl chr 1:227,957,302...227,965,386
JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO wortmannin inhibits the reaction [Cadmium Chloride results in increased expression of MT1 mRNA]; wortmannin inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA] CTD PMID:11551972 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt3 metallothionein 3 decreases response to substance ISO wortmannin results in decreased susceptibility to MT3 protein CTD PMID:19767621 NCBI chr19:11,324,708...11,326,112
Ensembl chr19:11,324,698...11,326,139
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO wortmannin inhibits the reaction [Capsaicin results in increased phosphorylation of MTOR protein] CTD PMID:19139269 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase multiple interactions ISO Wortmannin inhibits the reaction [Dopamine results in increased activity of MTR protein]; Wortmannin inhibits the reaction [IGF1 protein results in increased activity of MTR protein] CTD PMID:14745455 NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014
JBrowse link
G Mycn MYCN proto-oncogene, bHLH transcription factor multiple interactions ISO wortmannin inhibits the reaction [IGF1 protein results in increased expression of MYCN protein] CTD PMID:12569580 NCBI chr 6:38,222,554...38,228,419
Ensembl chr 6:38,222,555...38,228,379
JBrowse link
G Myh4 myosin heavy chain 4 multiple interactions ISO wortmannin inhibits the reaction [IGF1 protein results in increased expression of MYH4 mRNA] CTD PMID:19657059 NCBI chr10:53,778,456...53,801,605
Ensembl chr10:53,713,938...53,848,347
JBrowse link
G Myl7 myosin light chain 7 multiple interactions
decreases phosphorylation
ISO wortmannin inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein]
wortmannin results in decreased phosphorylation of MYL7 protein
CTD PMID:15621049 NCBI chr14:86,144,770...86,147,075
Ensembl chr14:86,143,862...86,147,553
JBrowse link
G Ncoa4 nuclear receptor coactivator 4 multiple interactions ISO Wortmannin inhibits the reaction [Palmitic Acid results in increased expression of NCOA4 protein] CTD PMID:32283200 NCBI chr16:8,302,950...8,323,294
Ensembl chr16:8,302,950...8,323,293
JBrowse link
G Ncs1 neuronal calcium sensor 1 multiple interactions EXP wortmannin inhibits the reaction [NCS1 protein results in increased phosphorylation of phosphatidylinositol 4-phosphate] CTD PMID:12471042 NCBI chr 3:10,556,250...10,602,672
Ensembl chr 3:10,553,589...10,602,672
JBrowse link
G Ndrg1 N-myc downstream regulated 1 decreases phosphorylation
multiple interactions
ISO wortmannin results in decreased phosphorylation of NDRG1 protein
wortmannin inhibits the reaction [INS1 protein results in increased phosphorylation of NDRG1 protein]
CTD PMID:20880397 NCBI chr 7:107,734,326...107,775,701
Ensembl chr 7:107,734,323...107,775,714
JBrowse link
G Nedd4 NEDD4 E3 ubiquitin protein ligase multiple interactions EXP wortmannin inhibits the reaction [Zinc Sulfate promotes the reaction [PTEN protein binds to NEDD4 protein]] CTD PMID:20100827 NCBI chr 8:79,323,408...79,408,842
Ensembl chr 8:79,323,408...79,408,833
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO wortmannin inhibits the reaction [Ozone results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:18207479 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Wortmannin inhibits the reaction [Bortezomib results in increased degradation of NFKBIA protein]; Wortmannin inhibits the reaction [Doxorubicin results in increased degradation of NFKBIA protein]; Wortmannin inhibits the reaction [Etoposide results in increased degradation of NFKBIA protein]; Wortmannin inhibits the reaction [evodiamine results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Wortmannin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of NFKBIA protein]
wortmannin inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of NFKBIA protein]]
CTD PMID:15142122 PMID:17935137 PMID:20005289 PMID:23170834 PMID:24085292 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ngf nerve growth factor multiple interactions
decreases activity
ISO
EXP
wortmannin inhibits the reaction [NGF results in increased localization of TRPV1 protein]; wortmannin inhibits the reaction [NGF results in increased susceptibility to Capsaicin]
wortmannin inhibits the reaction [NGF protein promotes the reaction [YWHAB protein binds to CDC5L protein]]; wortmannin inhibits the reaction [NGF protein promotes the reaction [YWHAB protein binds to PRPF19 protein modified form]]; wortmannin inhibits the reaction [NGF protein results in increased phosphorylation of AKT1 protein]
wortmannin results in decreased activity of NGF protein
CTD PMID:12815188 PMID:16319926 PMID:17324588 PMID:20629186 PMID:21975456 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
Carvedilol promotes the reaction [Wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Wortmannin inhibits the reaction [EDN1 protein inhibits the reaction [TNF protein results in increased expression of NOS2 protein]]; Wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
Wortmannin inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]
wortmannin promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]
CTD PMID:12839867 PMID:17159805 PMID:22952890 PMID:24462917 PMID:25352548 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
decreases phosphorylation
ISO
EXP
Fenofibrate inhibits the reaction [wortmannin results in decreased phosphorylation of NOS3 protein]; wortmannin inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of NOS3 protein]; wortmannin inhibits the reaction [diallyl disulfide results in increased phosphorylation of NOS3 protein]; wortmannin inhibits the reaction [diallyl trisulfide results in increased phosphorylation of NOS3 protein]; wortmannin inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of and results in increased expression of NOS3 protein]]; wortmannin inhibits the reaction [Progesterone promotes the reaction [Estradiol results in increased activity of NOS3 protein]]; wortmannin inhibits the reaction [Progesterone results in increased activity of NOS3 protein]; wortmannin inhibits the reaction [Progesterone results in increased phosphorylation of NOS3 protein]; wortmannin inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of NOS3 protein]; wortmannin inhibits the reaction [rosiglitazone inhibits the reaction [[Glucose results in decreased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]]; wortmannin inhibits the reaction [rosiglitazone inhibits the reaction [Glucose results in decreased phosphorylation of NOS3 protein]]; wortmannin inhibits the reaction [Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of and results in increased expression of NOS3 protein]]
wortmannin affects the reaction [Carbon Tetrachloride results in increased phosphorylation of and results in increased activity of NOS3 protein]
CTD PMID:11788791 PMID:15358673 PMID:16442496 PMID:18296501 PMID:18317400 PMID:18710710 PMID:19767878 PMID:20229525 PMID:20562903 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Notch1 notch receptor 1 multiple interactions ISO wortmannin inhibits the reaction [Zinc affects the localization of NOTCH1 protein]; wortmannin inhibits the reaction [Zinc results in decreased activity of NOTCH1 protein] CTD PMID:17513037 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO wortmannin inhibits the reaction [plumbagin results in increased expression of NQO1 protein] CTD PMID:20028456 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 multiple interactions ISO wortmannin inhibits the reaction [Estradiol results in increased activity of NR5A1 protein] CTD PMID:19549922 NCBI chr 3:22,998,900...23,020,441
Ensembl chr 3:22,999,616...23,020,441
JBrowse link
G Ntf3 neurotrophin 3 decreases transport ISO wortmannin results in decreased transport of NTF3 protein CTD PMID:11948662 NCBI chr 4:158,636,883...158,705,886
Ensembl chr 4:158,636,884...158,705,886
JBrowse link
G Ntf4 neurotrophin 4 decreases transport ISO wortmannin results in decreased transport of NTF4 protein CTD PMID:11948662 NCBI chr 1:101,405,314...101,408,145
Ensembl chr 1:101,405,314...101,408,145
JBrowse link
G Nts neurotensin multiple interactions ISO wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]; wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:15177934 NCBI chr 7:44,111,594...44,120,998
Ensembl chr 7:44,111,151...44,121,130
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO wortmannin promotes the reaction [Doxorubicin results in increased cleavage of PARP1 protein]; wortmannin promotes the reaction [Etoposide results in increased cleavage of PARP1 protein]; wortmannin promotes the reaction [sodium arsenite results in increased degradation of PARP1 protein]
wortmannin inhibits the reaction [Cyclosporine results in increased cleavage of PARP1 protein]
CTD PMID:12614848 PMID:17935137 PMID:22155090 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions EXP [troglitazone co-treated with wortmannin] results in decreased expression of PCK1 mRNA CTD PMID:10446394 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Pdcd4 programmed cell death 4 increases expression ISO Wortmannin results in increased expression of PDCD4 mRNA; Wortmannin results in increased expression of PDCD4 protein CTD PMID:17259349 NCBI chr 1:274,616,625...274,648,204
Ensembl chr 1:274,625,224...274,648,204
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 multiple interactions ISO wortmannin inhibits the reaction [Dexamethasone results in increased phosphorylation of PDK1 protein] CTD PMID:21655274 NCBI chr 3:58,530,870...58,561,494
Ensembl chr 3:58,530,870...58,558,027
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 multiple interactions ISO wortmannin inhibits the reaction [Glucose affects the localization of PDX1 protein]
[wortmannin co-treated with INS protein] inhibits the reaction [Glucose affects the localization of PDX1 protein]; wortmannin inhibits the reaction [Glucose affects the localization of PDX1 protein]; wortmannin inhibits the reaction [Glucose results in increased phosphorylation of and results in increased activity of PDX1 protein]
CTD PMID:9873045 PMID:11574405 NCBI chr12:9,496,044...9,501,211
Ensembl chr12:9,496,044...9,501,213
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha multiple interactions
decreases activity
ISO wortmannin inhibits the reaction [Sirolimus results in increased activity of PIK3CA protein]
wortmannin results in decreased activity of PIK3CA protein
CTD PMID:16227402 PMID:19036708 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta decreases activity ISO wortmannin results in decreased activity of PIK3CB protein CTD PMID:11931710 NCBI chr 8:107,275,849...107,381,088
Ensembl chr 8:107,275,725...107,380,933
JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta decreases activity ISO wortmannin results in decreased activity of PIK3CD protein CTD PMID:21644799 NCBI chr 5:166,602,053...166,628,028
Ensembl chr 5:166,602,053...166,628,028
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma multiple interactions
decreases activity
ISO
EXP
wortmannin inhibits the reaction [Isoproterenol results in increased activity of PIK3CG protein]
wortmannin promotes the reaction [GRK2 protein promotes the reaction [GRK2 protein binds to PIK3CG protein]]
wortmannin results in decreased activity of PIK3CG protein
CTD PMID:15178407 PMID:21644799 PMID:28759639 NCBI chr 6:51,465,696...51,501,234
Ensembl chr 6:51,465,908...51,498,337
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 decreases activity
multiple interactions
ISO
EXP
wortmannin results in decreased activity of PIK3R1 protein
Wortmannin inhibits the reaction [nonylphenol results in decreased expression of PIK3R1 protein]; Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of PIK3R1 mRNA]]
CTD PMID:19036708 PMID:27832966 PMID:32805344 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Plac1 placenta enriched 1 multiple interactions ISO wortmannin inhibits the reaction [FGF7 protein results in increased expression of PLAC1 mRNA] CTD PMID:15803460 NCBI chr  X:157,931,450...158,133,506
Ensembl chr  X:158,569,056...158,569,577
Ensembl chr  X:158,569,056...158,569,577
JBrowse link
G Pln phospholamban multiple interactions EXP wortmannin inhibits the reaction [Progesterone inhibits the reaction [bisphenol A results in increased phosphorylation of PLN protein]] CTD PMID:28324061 NCBI chr20:34,633,157...34,642,904
Ensembl chr20:34,633,157...34,642,904
JBrowse link
G Postn periostin multiple interactions EXP wortmannin inhibits the reaction [AGT protein results in increased expression of POSTN mRNA]; wortmannin inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA] CTD PMID:15121739 NCBI chr 2:143,656,820...143,688,087
Ensembl chr 2:143,656,793...143,688,087
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP wortmannin inhibits the reaction [bisphenol A results in decreased expression of PPARA mRNA] CTD PMID:23399309 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions EXP wortmannin inhibits the reaction [bisphenol A results in decreased expression of PPARD mRNA] CTD PMID:23399309 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP wortmannin inhibits the reaction [bisphenol A results in decreased expression of PPARG mRNA] CTD PMID:23399309 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D multiple interactions ISO wortmannin inhibits the reaction [Soil Pollutants results in increased expression of PPM1D protein] CTD PMID:22409540 NCBI chr10:72,909,550...72,945,884
Ensembl chr10:72,909,550...72,945,884
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B multiple interactions ISO wortmannin inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein] CTD PMID:17209049 NCBI chr10:86,303,727...86,312,770
Ensembl chr10:86,303,727...86,312,762
JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO wortmannin inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; wortmannin inhibits the reaction [Oxygen deficiency results in increased activity of and results in increased localization of PRKCD protein] CTD PMID:11424089 PMID:17171638 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit multiple interactions ISO PRKDC protein affects the susceptibility to [wortmannin co-treated with Benzo(a)pyrene] CTD PMID:20888899 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871
JBrowse link
G Prpf19 pre-mRNA processing factor 19 multiple interactions EXP wortmannin inhibits the reaction [NGF protein promotes the reaction [YWHAB protein binds to PRPF19 protein modified form]] CTD PMID:20629186 NCBI chr 1:226,947,065...226,958,147
Ensembl chr 1:226,947,105...226,958,144
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO
EXP
Wortmannin inhibits the reaction [PTEN protein results in increased susceptibility to Doxorubicin]; Wortmannin inhibits the reaction [PTEN protein results in increased susceptibility to Etoposide]
Wortmannin inhibits the reaction [nonylphenol results in decreased expression of PTEN protein]; Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in increased expression of PTEN mRNA]]; Wortmannin inhibits the reaction [Zinc Sulfate promotes the reaction [PTEN protein binds to NEDD4 protein]]; Wortmannin inhibits the reaction [Zinc Sulfate results in decreased expression of PTEN protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased ubiquitination of PTEN protein]
CTD PMID:17935137 PMID:20100827 PMID:27832966 PMID:32805344 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptger1 prostaglandin E receptor 1 multiple interactions ISO wortmannin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein]; wortmannin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased phosphorylation of RPS6 protein] CTD PMID:20335389 NCBI chr19:24,799,422...24,803,373
Ensembl chr19:24,800,072...24,803,373
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO wortmannin inhibits the reaction [PTGS2 protein results in decreased susceptibility to Carboplatin]; wortmannin inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]; wortmannin inhibits the reaction [Zinc results in increased expression of PTGS2 mRNA]; wortmannin inhibits the reaction [Zinc results in increased expression of PTGS2 protein]
Wortmannin inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 mRNA]; Wortmannin inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 protein]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]
CTD PMID:15980035 PMID:18089846 PMID:18840457 PMID:22952890 PMID:23968725 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions ISO
EXP
[Pilocarpine co-treated with wortmannin] results in increased phosphorylation of PTK2 protein; [Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein; [wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein; [wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein; [wortmannin co-treated with Tetradecanoylphorbol Acetate] inhibits the reaction [oxotremorine M results in increased phosphorylation of PTK2 protein]; Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein]]; oxotremorine M inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]; oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]; oxotremorine M promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein]; wortmannin inhibits the reaction [Testosterone results in increased phosphorylation of PTK2 protein]
[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein; KNG1 protein inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]; wortmannin inhibits the reaction [KNG1 protein results in increased phosphorylation of PTK2 protein]
CTD PMID:10537051 PMID:16038899 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Pxn paxillin multiple interactions ISO [oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]; Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]]; wortmannin inhibits the reaction [oxotremorine M results in increased phosphorylation of PXN protein] CTD PMID:10537051 NCBI chr12:46,797,953...46,845,107
Ensembl chr12:46,797,954...46,845,080
JBrowse link
G Rad23b RAD23 homolog B, nucleotide excision repair protein multiple interactions ISO wortmannin inhibits the reaction [Cisplatin results in increased expression of RAD23B protein] CTD PMID:21742020 NCBI chr 5:72,103,704...72,141,701
Ensembl chr 5:72,103,704...72,141,700
JBrowse link
G Rad50 RAD50 double strand break repair protein multiple interactions ISO [wortmannin co-treated with docetaxel] results in decreased expression of RAD50 protein CTD PMID:20878124 NCBI chr10:39,002,130...39,054,042
Ensembl chr10:39,001,498...39,054,142
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO wortmannin promotes the reaction [hydroxyflutamide results in increased phosphorylation of RAF1 protein]; wortmannin promotes the reaction [ON123300 results in increased phosphorylation of RAF1 protein] CTD PMID:24568969 PMID:28163245 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family multiple interactions ISO wortmannin inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein] CTD PMID:16963453 NCBI chr 2:208,193,950...208,215,186
Ensembl chr 2:208,193,954...208,215,187
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO
EXP
wortmannin inhibits the reaction [KITL protein results in increased phosphorylation of RB1 protein]; wortmannin inhibits the reaction [Vanadates results in increased phosphorylation of RB1 protein]
Wortmannin inhibits the reaction [1,1-dimethylbutyl-1-deoxy-Delta(9)-THC inhibits the reaction [Magnesium deficiency results in decreased phosphorylation of RB1 protein]]
CTD PMID:10849422 PMID:14971663 PMID:30542433 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions ISO wortmannin inhibits the reaction [Norepinephrine affects the localization of REL protein]; wortmannin inhibits the reaction [Norepinephrine promotes the reaction [REL protein binds to ICAM1 promoter]] CTD PMID:23114885 NCBI chr14:108,490,794...108,517,582
Ensembl chr14:108,491,069...108,509,892
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
wortmannin inhibits the reaction [Ozone results in increased activity of [NFKB1 protein binds to RELA protein]]; wortmannin inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of RELA protein]
Wortmannin inhibits the reaction [Mevinphos results in increased activity of RELA protein]; Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in increased expression of RELA protein]]
CTD PMID:17982072 PMID:18207479 PMID:24462917 PMID:32805344 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Riox2 ribosomal oxygenase 2 multiple interactions ISO wortmannin inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 mRNA] CTD PMID:24434654 NCBI chr11:43,006,190...43,028,722
Ensembl chr11:43,006,757...43,022,565
JBrowse link
G Rps6 ribosomal protein S6 multiple interactions ISO Wortmannin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased phosphorylation of RPS6 protein]; Wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of RPS6 protein] CTD PMID:20335389 PMID:23001822 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
Ensembl chr 5:105,197,857...105,200,148
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
decreases phosphorylation
EXP
ISO
wortmannin inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]
wortmannin inhibits the reaction [INS protein results in increased expression of RPS6KB1 protein modified form]
wortmannin results in decreased phosphorylation of RPS6KB1 protein
wortmannin inhibits the reaction [arsenite affects the activity of RPS6KB1 protein]
CTD PMID:14516795 PMID:20936651 PMID:21195169 PMID:25663935 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 multiple interactions ISO wortmannin inhibits the reaction [Phosphatidic Acids results in increased activity of RPS6KB2 protein] CTD PMID:12087098 NCBI chr 1:219,406,201...219,412,888
Ensembl chr 1:219,406,202...219,412,888
JBrowse link
G Scg2 secretogranin II decreases activity ISO wortmannin results in decreased activity of SCG2 protein alternative form CTD PMID:9473216 NCBI chr 9:85,237,460...85,243,024
Ensembl chr 9:85,237,458...85,243,001
JBrowse link
G Sct secretin multiple interactions EXP wortmannin inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid analog]; wortmannin inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid]; wortmannin inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT] CTD PMID:22194894 NCBI chr 1:214,264,865...214,277,437
Ensembl chr 1:214,264,754...214,265,668
JBrowse link
G Selenop selenoprotein P increases expression ISO wortmannin results in increased expression of SELENOP protein CTD PMID:24535192 NCBI chr 2:53,105,912...53,116,198
Ensembl chr 2:53,109,684...53,114,858
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO wortmannin inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of SERPINE1 protein]; wortmannin inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA] CTD PMID:16458614 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Serpinh1 serpin family H member 1 multiple interactions ISO wortmannin inhibits the reaction [cobaltous chloride results in decreased expression of SERPINH1 mRNA]; wortmannin inhibits the reaction [cobaltous chloride results in decreased expression of SERPINH1 protein] CTD PMID:13679210 NCBI chr 1:164,301,010...164,308,306
Ensembl chr 1:164,301,010...164,308,317
JBrowse link
G Sftpc surfactant protein C decreases expression ISO wortmannin results in decreased expression of SFTPC protein CTD PMID:15695173 NCBI chr15:52,211,538...52,214,480
Ensembl chr15:52,211,544...52,214,616
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 multiple interactions ISO wortmannin inhibits the reaction [Dexamethasone results in increased phosphorylation of SGK1 protein] CTD PMID:21655274 NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
JBrowse link
G Shbg sex hormone binding globulin multiple interactions EXP wortmannin inhibits the reaction [nonylphenol results in increased expression of SHBG mRNA] CTD PMID:27832966 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link
G Sirpa signal-regulatory protein alpha multiple interactions ISO wortmannin inhibits the reaction [SIRPA protein inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]] CTD PMID:12805067 NCBI chr 3:122,113,735...122,152,478
Ensembl chr 3:122,114,108...122,152,477
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO wortmannin promotes the reaction [arsenic disulfide results in decreased expression of SIRT1 protein]
wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]]
CTD PMID:18298901 PMID:22952890 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc1a1 solute carrier family 1 member 1 multiple interactions
decreases activity
EXP wortmannin inhibits the reaction [Carbamazepine results in increased activity of SLC1A1 protein]; wortmannin inhibits the reaction [Pregabalin results in increased activity of SLC1A1 protein]; wortmannin inhibits the reaction [Progesterone results in increased activity of SLC1A1 protein]
wortmannin results in decreased activity of SLC1A1 protein
CTD PMID:16150575 PMID:22511482 PMID:23262392 PMID:23602688 PMID:24355585 NCBI chr 1:246,955,017...247,035,159
Ensembl chr 1:246,954,980...247,037,056
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP
ISO
wortmannin inhibits the reaction [AICA ribonucleotide results in increased localization of SLC2A4 protein]
wortmannin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein]
CTD PMID:11978788 PMID:18591783 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Slc2a5 solute carrier family 2 member 5 multiple interactions EXP wortmannin inhibits the reaction [Fructose results in increased expression of and results in increased activity of SLC2A5 protein] CTD PMID:15691865 NCBI chr 5:167,142,182...167,174,203
Ensembl chr 5:167,141,875...167,174,310
JBrowse link
G Slc5a5 solute carrier family 5 member 5 multiple interactions ISO wortmannin inhibits the reaction [Carbamazepine promotes the reaction [Tretinoin results in increased expression of SLC5A5 protein]] CTD PMID:20300827 NCBI chr16:20,297,414...20,307,401
Ensembl chr16:20,297,414...20,307,400
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO wortmannin inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine] CTD PMID:20875051 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions ISO wortmannin inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 mRNA]; wortmannin inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 protein] CTD PMID:22685291 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Sod2 superoxide dismutase 2 increases expression EXP wortmannin results in increased expression of SOD2 mRNA CTD PMID:20596034 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sort1 sortilin 1 multiple interactions
increases ubiquitination
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [wortmannin results in increased degradation of SORT1 protein]; wortmannin inhibits the reaction [INS1 protein results in increased expression of SORT1 protein]; wortmannin results in decreased expression of and results in increased degradation of SORT1 protein
wortmannin results in increased ubiquitination of SORT1 protein
CTD PMID:25805502 NCBI chr 2:211,078,092...211,156,312
Ensembl chr 2:211,078,334...211,156,312
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of SP1 protein] CTD PMID:17441964 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression
decreases expression
ISO [wortmannin co-treated with Ethanol] results in increased expression of SQSTM1 protein
wortmannin results in increased expression of SQSTM1 protein
wortmannin results in decreased expression of SQSTM1 protein
CTD PMID:22459179 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of SRC protein] CTD PMID:25856345 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP Wortmannin inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; Wortmannin inhibits the reaction [Glucose results in increased cleavage of SREBF1 protein] CTD PMID:22031849 PMID:25398788 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP wortmannin inhibits the reaction [Atrazine promotes the reaction [FSHB protein results in increased expression of STAR mRNA]]; wortmannin inhibits the reaction [FSHB protein results in increased expression of STAR mRNA] CTD PMID:25253736 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Sts steroid sulfatase multiple interactions ISO wortmannin inhibits the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased activity of STS protein]; wortmannin inhibits the reaction [AGN 195183 results in increased activity of STS protein]; wortmannin inhibits the reaction [IGF2 protein results in increased expression of STS mRNA]; wortmannin inhibits the reaction [tazarotene results in increased activity of STS protein]; wortmannin inhibits the reaction [Tretinoin results in increased activity of STS protein] CTD PMID:16178010 PMID:24055520 NCBI chr  X:45,420,418...45,428,748
Ensembl chr  X:45,420,596...45,428,750
JBrowse link
G Tert telomerase reverse transcriptase multiple interactions ISO Wortmannin inhibits the reaction [Camptothecin results in increased phosphorylation of TERT protein] CTD PMID:30851366 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 multiple interactions ISO wortmannin inhibits the reaction [arsenic trioxide results in increased expression of TGIF1 protein] CTD PMID:21649584 NCBI chr 9:119,181,079...119,190,698
Ensembl chr 9:119,181,083...119,190,698
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO
EXP
wortmannin affects the reaction [HU 211 results in decreased expression of TH mRNA]
[wortmannin co-treated with manganese chloride] results in decreased expression of TH protein
CTD PMID:18950629 PMID:23604964 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO wortmannin binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions ISO wortmannin inhibits the reaction [CYP4Z1 protein results in increased expression of TIMP2 mRNA] CTD PMID:22841774 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO wortmannin inhibits the reaction [telmisartan affects the localization of TJP1 protein]; wortmannin inhibits the reaction [telmisartan results in decreased expression of TJP1 mRNA]; wortmannin inhibits the reaction [telmisartan results in decreased expression of TJP1 protein] CTD PMID:19252288 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases response to substance
ISO
EXP
Wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]; Wortmannin inhibits the reaction [Dieldrin results in increased expression of TNF mRNA]; Wortmannin inhibits the reaction [SIRPA protein inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; Wortmannin inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of SERPINE1 protein]; Wortmannin inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]; Wortmannin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; Wortmannin promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]
Wortmannin results in increased susceptibility to TNF protein
Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in increased expression of TNF protein]]; Wortmannin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]
wortmannin inhibits the reaction [EDN1 protein inhibits the reaction [TNF protein results in increased expression of NOS2 protein]]; wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]]; wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]
CTD PMID:12805067 PMID:12839867 PMID:16458614 PMID:16968468 PMID:17464197 PMID:19810018 PMID:22556157 PMID:22952890 PMID:25352548 PMID:31068361 PMID:31445927 PMID:32805344 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions
decreases phosphorylation
ISO
EXP
Wortmannin inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of TP53 protein]; Wortmannin inhibits the reaction [3,3'-diindolylmethane results in increased phosphorylation of TP53 protein]; Wortmannin inhibits the reaction [Asbestos, Serpentine results in increased expression of TP53 protein]; Wortmannin inhibits the reaction [Asbestos, Serpentine results in increased phosphorylation of TP53 protein]; Wortmannin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of TP53 protein]; Wortmannin inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of TP53 protein]]; Wortmannin inhibits the reaction [Mustard Gas results in increased expression of TP53 protein]; Wortmannin inhibits the reaction [Mustard Gas results in increased phosphorylation of TP53 protein]; Wortmannin inhibits the reaction [Nitric Oxide results in increased phosphorylation of TP53 protein]; Wortmannin inhibits the reaction [Resveratrol results in increased phosphorylation of TP53 protein]; Wortmannin inhibits the reaction [spermine nitric oxide complex results in increased phosphorylation of TP53 protein]; Wortmannin promotes the reaction [arsenic disulfide results in increased expression of and results in increased phosphorylation of TP53 protein]; Wortmannin results in decreased phosphorylation of and results in decreased expression of TP53 protein
wortmannin results in decreased phosphorylation of TP53 protein
wortmannin inhibits the reaction [Diethylnitrosamine results in increased expression of TP53 protein]; wortmannin inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of TP53 protein]
CTD PMID:11751435 PMID:12676607 PMID:15489221 PMID:15837074 PMID:16024610 PMID:17534123 PMID:18298901 PMID:19111594 PMID:22119920 PMID:22290291 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp73 tumor protein p73 multiple interactions ISO wortmannin promotes the reaction [Cisplatin results in increased expression of TP73 protein]; wortmannin promotes the reaction [Doxorubicin results in increased expression of TP73 protein] CTD PMID:21214929 NCBI chr 5:171,355,876...171,415,354
Ensembl chr 5:171,355,876...171,415,354
JBrowse link
G Tpp2 tripeptidyl peptidase 2 multiple interactions ISO wortmannin promotes the reaction [Etoposide affects the localization of TPP2 protein] CTD PMID:20643100 NCBI chr 9:50,664,048...50,744,803
NCBI chr 9:50,578,868...50,628,943
Ensembl chr 9:50,581,234...50,744,803
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions ISO wortmannin inhibits the reaction [NGF results in increased localization of TRPV1 protein] CTD PMID:16319926 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Tyr tyrosinase multiple interactions ISO [Colforsin co-treated with Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased expression of TYR protein; [Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] promotes the reaction [Colforsin results in increased expression of TYR protein]; [Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased expression of TYR protein
[Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased expression of TYR protein
CTD PMID:28849034 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO [4'-hydroxywogonin co-treated with Wortmannin] inhibits the reaction [IL6 protein results in increased expression of and results in increased secretion of VEGFA protein]; [4'-hydroxywogonin co-treated with Wortmannin] inhibits the reaction [IL6 protein results in increased expression of VEGFA mRNA]; Wortmannin inhibits the reaction [4-hydroxyestradiol results in increased expression of VEGFA protein]; Wortmannin inhibits the reaction [4-tert-octylphenol results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [butylbenzyl phthalate results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [cobaltous chloride results in increased expression of VEGFA mRNA]; Wortmannin inhibits the reaction [cobaltous chloride results in increased expression of VEGFA protein]; Wortmannin inhibits the reaction [CYP4Z1 protein results in increased expression of VEGFA mRNA]; Wortmannin inhibits the reaction [Dieldrin results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [Estradiol results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [Genistein results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [IGF1 protein results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [IL6 protein results in increased expression of and results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [IL6 protein results in increased expression of VEGFA mRNA]; Wortmannin inhibits the reaction [Oxaliplatin results in increased expression of VEGFA protein]; Wortmannin inhibits the reaction [sodium arsenite results in increased expression of VEGFA protein] CTD PMID:13679210 PMID:15050414 PMID:16499871 PMID:18252963 PMID:18790786 PMID:22841774 PMID:23968725 PMID:30217479 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vim vimentin decreases expression ISO wortmannin results in decreased expression of VIM protein CTD PMID:25856345 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Xrcc5 X-ray repair cross complementing 5 multiple interactions ISO [wortmannin co-treated with docetaxel] results in decreased expression of XRCC5 protein CTD PMID:20878124 NCBI chr 9:79,659,275...79,748,050
Ensembl chr 9:79,659,251...79,748,078
JBrowse link
G Xrcc6 X-ray repair cross complementing 6 multiple interactions ISO [wortmannin co-treated with docetaxel] results in decreased expression of XRCC6 protein CTD PMID:20878124 NCBI chr 7:123,259,881...123,280,613
Ensembl chr 7:123,259,761...123,280,612
JBrowse link
G Yap1 Yes1 associated transcriptional regulator multiple interactions ISO wortmannin promotes the reaction [Cisplatin results in increased expression of YAP1 protein modified form]; wortmannin promotes the reaction [Doxorubicin results in increased expression of YAP1 protein modified form] CTD PMID:21214929 NCBI chr 8:6,133,014...6,204,240
Ensembl chr 8:6,135,493...6,203,579
JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta multiple interactions EXP wortmannin inhibits the reaction [NGF protein promotes the reaction [YWHAB protein binds to CDC5L protein]]; wortmannin inhibits the reaction [NGF protein promotes the reaction [YWHAB protein binds to PRPF19 protein modified form]] CTD PMID:20629186 NCBI chr 3:160,391,108...160,399,931
Ensembl chr 3:160,391,106...160,399,931
JBrowse link
G Zfp143 zinc finger protein 143 multiple interactions ISO wortmannin inhibits the reaction [IGF1 protein results in increased expression of ZNF143 protein] CTD PMID:20733350 NCBI chr 1:174,702,310...174,738,133
Ensembl chr 1:174,702,373...174,738,126
JBrowse link
PX-866 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO PX-866 results in decreased phosphorylation of AKT1 protein
PX-866 inhibits the reaction [[Calcium co-treated with Ionomycin] results in increased phosphorylation of AKT1 protein]; PX-866 promotes the reaction [STO 609 results in decreased phosphorylation of AKT1 protein]; STO 609 promotes the reaction [PX-866 results in decreased phosphorylation of AKT1 protein]
CTD PMID:25805502 PMID:28634229 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bad BCL2-associated agonist of cell death decreases phosphorylation
multiple interactions
ISO PX-866 results in decreased phosphorylation of BAD protein
[PX-866 co-treated with BBR3610] results in decreased phosphorylation of BAD protein
CTD PMID:20473884 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 affects response to substance ISO CAMKK2 protein affects the susceptibility to PX-866 CTD PMID:28634229 NCBI chr12:39,253,409...39,302,601
Ensembl chr12:39,253,409...39,302,601
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO [PX-866 co-treated with SORT1 protein] results in decreased expression of CD36 mRNA CTD PMID:25805502 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO [PX-866 co-treated with SORT1 protein] results in decreased expression of CYP7A1 mRNA CTD PMID:25805502 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO PX-866 promotes the reaction [SORT1 protein results in decreased expression of FASN mRNA] CTD PMID:25805502 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions ISO PX-866 promotes the reaction [SORT1 protein results in decreased expression of MTTP mRNA] CTD PMID:25805502 NCBI chr 2:243,366,181...243,407,608
Ensembl chr 2:243,366,181...243,407,608
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO PX-866 promotes the reaction [SORT1 protein results in decreased expression of SCD1 mRNA] CTD PMID:25805502 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Sort1 sortilin 1 multiple interactions
decreases expression
ISO [PX-866 co-treated with SORT1 protein] results in decreased expression of CD36 mRNA; [PX-866 co-treated with SORT1 protein] results in decreased expression of CYP7A1 mRNA; PX-866 promotes the reaction [SORT1 protein results in decreased expression of FASN mRNA]; PX-866 promotes the reaction [SORT1 protein results in decreased expression of MTTP mRNA]; PX-866 promotes the reaction [SORT1 protein results in decreased expression of SCD1 mRNA]; SORT1 protein inhibits the reaction [PX-866 results in increased abundance of Triglycerides]
PX-866 results in decreased expression of SORT1 protein
CTD PMID:25805502 NCBI chr 2:211,078,092...211,156,312
Ensembl chr 2:211,078,334...211,156,312
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    role 19711
      biological role 19711
        antimicrobial agent 17369
          antiviral agent 10271
            anticoronaviral agent 8971
              wortmannin 265
                PX-866 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            organic group 18593
                              organic divalent group 18584
                                organodiyl group 18584
                                  carbonyl group 18499
                                    carbonyl compound 18499
                                      carboxylic acid 18151
                                        monocarboxylic acid 17523
                                          acetic acid 10825
                                            acetate ester 3817
                                              wortmannin 265
                                                PX-866 9
paths to the root