photochemical role - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	photochemical role	go back to main search page
Accession:	CHEBI:52215	browse the term
Definition:	A chemical role played by the molecular entity or part thereof in a photochemical process.
Synonyms:	related_synonym:	photochemical roles

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Rat (412 ) Mouse (404 ) Human (410 ) Chinchilla (0 ) Bonobo (0 ) Dog (0 ) Squirrel (0 ) Pig (1 ) Green Monkey (0) Naked Mole-rat (0 ) All
Genes (404)

3,6-diaminoacridine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

androgen receptor

multiple interactions

ISO

Proflavine inhibits the reaction [Metribolone results in increased activity of AR protein]

NCBI chr X:97,192,363...97,366,824
Ensembl chr X:97,192,375...97,366,821

G

estrogen receptor 1 (alpha)

increases activity

ISO

Proflavine results in increased activity of ESR1 protein

NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614

G

estrogen related receptor, alpha

multiple interactions

ISO

Proflavine inhibits the reaction [XCT790 results in decreased activity of ESRRA protein]

NCBI chr19:6,888,345...6,899,182
Ensembl chr19:6,888,345...6,899,208

G

potassium voltage-gated channel, subfamily H (eag-related), member 2

decreases activity

ISO

Proflavine results in decreased activity of KCNH2 protein

NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602

G

nuclear factor, erythroid derived 2, like 2

increases activity

ISO

Proflavine results in increased activity of NFE2L2 protein

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

nuclear receptor subfamily 1, group H, member 4

multiple interactions

ISO

Proflavine inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; Proflavine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]

PMID:25257666 PMID:30818834

NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions

ISO

Proflavine inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of NR1I3 protein]

NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270

G

progesterone receptor

multiple interactions

ISO

Proflavine inhibits the reaction [Promegestone results in increased activity of PGR protein]

NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612

G

peroxisome proliferator activated receptor gamma

multiple interactions

ISO

Proflavine inhibits the reaction [Rosiglitazone results in increased activity of PPARG protein]

NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360

G

transformation related protein 53

increases activity
affects activity

ISO

Proflavine results in increased activity of TP53 protein
Proflavine affects the activity of TP53 protein

PMID:30818834 PMID:35435491

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity
multiple interactions

ISO

alizarin results in decreased activity of CYP1A1 protein
alizarin affects the reaction [Benzo(a)pyrene affects the activity of CYP1A1 protein]

PMID:12379470 PMID:37515497

NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

ISO

alizarin results in decreased activity of CYP1A2 protein

PMID:12379470 PMID:33438235

NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

ISO

alizarin results in decreased activity of CYP1B1 protein

NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490

G

cytochrome P450, family 2, subfamily a, polypeptide 5

decreases activity

ISO

alizarin results in decreased activity of CYP2A6 protein

NCBI chr 7:26,534,764...26,542,689
Ensembl chr 7:26,534,730...26,542,973

G

cytochrome P450, family 2, subfamily c, polypeptide 65

decreases activity

ISO

alizarin results in decreased activity of CYP2C9 protein

NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases activity

ISO

alizarin results in decreased activity of CYP2E1 protein

NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900

G

estrogen receptor 1 (alpha)

multiple interactions

ISO

alizarin binds to and results in increased activity of ESR1 protein

NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614

G

H2A.X variant histone

multiple interactions

ISO

alizarin inhibits the reaction [Benzo(a)pyrene results in increased expression of H2AX protein]

NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374

G

mitogen-activated protein kinase 1

multiple interactions

ISO

alizarin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; alizarin inhibits the reaction [Indican results in increased phosphorylation of MAPK1 protein]

PMID:33421718 PMID:38670245

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

multiple interactions

ISO

alizarin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK3 protein]

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

mucin 5, subtypes A and C, tracheobronchial/gastric

multiple interactions

ISO

alizarin inhibits the reaction [Benzo(a)pyrene results in increased expression of MUC5AC mRNA]; alizarin inhibits the reaction [Benzo(a)pyrene results in increased expression of MUC5AC protein]

NCBI chr 7:141,342,695...141,372,964
Ensembl chr 7:141,342,709...141,372,968

G

N-acetyl transferase 1

decreases activity

ISO

alizarin results in decreased activity of NAT1 protein

NCBI chr 8:67,943,620...67,945,183
Ensembl chr 8:67,933,573...67,944,756

G

UDP glucuronosyltransferase 1 family, polypeptide A1

increases glucuronidation

ISO

UGT1A1 protein results in increased glucuronidation of alizarin

NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719

G

UDP glycosyltransferase 1 family, polypeptide A10

increases glucuronidation

ISO

UGT1A10 protein results in increased glucuronidation of alizarin

NCBI chr 1:87,983,133...88,147,724
Ensembl chr 1:87,983,110...88,146,726

G

UDP glucuronosyltransferase 1 family, polypeptide A9

increases glucuronidation

ISO

UGT1A9 protein results in increased glucuronidation of alizarin

NCBI chr 1:87,998,501...88,147,724
Ensembl chr 1:87,998,522...88,146,719

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin II receptor, type 1a

multiple interactions

ISO

esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGTR1A mRNA]; esculetin inhibits the reaction [Dietary Fats results in increased expression of AGTR1A mRNA]

NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850

G

angiotensin II receptor, type 2

multiple interactions

ISO

esculetin inhibits the reaction [Dietary Fats results in increased expression of AGTR2 mRNA]; esculetin promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGTR2 mRNA]

NCBI chr X:21,350,863...21,355,072
Ensembl chr X:21,350,783...21,355,403

G

thymoma viral proto-oncogene 1

increases phosphorylation

ISO

esculetin results in increased phosphorylation of AKT1 protein

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

G

arachidonate 15-lipoxygenase

decreases expression

ISO

esculetin results in decreased expression of ALOX15 protein

NCBI chr11:70,234,973...70,279,465
Ensembl chr11:70,234,978...70,242,857

G

BCL2-antagonist/killer 1

increases expression

ISO

esculetin results in increased expression of BAK1 protein

NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983

G

BCL2-associated X protein

multiple interactions
increases expression
affects expression
affects localization

ISO

[esculetin co-treated with Paclitaxel] results in increased expression of BAX protein
esculetin results in increased expression of BAX protein
esculetin affects the expression of BAX protein
esculetin affects the localization of BAX protein

PMID:16051289 PMID:19786087 PMID:24995577 PMID:26388407 PMID:31313495

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

B cell leukemia/lymphoma 2

affects expression
decreases expression

ISO

esculetin affects the expression of BCL2 protein
esculetin results in decreased expression of BCL2 protein

PMID:24995577 PMID:26388407 PMID:31313495

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

BCL2-like 1

multiple interactions
decreases expression

ISO

[esculetin co-treated with Paclitaxel] results in decreased expression of BCL2L1 protein
esculetin results in decreased expression of BCL2L1 protein

PMID:16051289 PMID:26388407

NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648

G

BH3 interacting domain death agonist

multiple interactions

ISO

[arsenic trioxide co-treated with esculetin] results in increased cleavage of BID protein

NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814

G

bone morphogenetic protein 6

multiple interactions

ISO

esculetin inhibits the reaction [Streptozocin results in decreased expression of BMP6 mRNA]

NCBI chr13:38,529,098...38,684,283
Ensembl chr13:38,529,083...38,684,278

G

caspase 3

multiple interactions
increases cleavage
increases activity

ISO

[esculetin co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP3 protein
esculetin results in increased cleavage of CASP3 protein
esculetin results in increased activity of CASP3 protein

PMID:16051289 PMID:24995577 PMID:26388407 PMID:31313495

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 7

increases cleavage

ISO

esculetin results in increased cleavage of CASP7 protein

NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776

G

caspase 8

multiple interactions

ISO

[esculetin co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP8 protein

NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662

G

caspase 9

increases activity
increases cleavage

ISO

esculetin results in increased activity of CASP9 protein
esculetin results in increased cleavage of CASP9 protein

PMID:24995577 PMID:26388407 PMID:31313495

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

catalase

multiple interactions

ISO

esculetin inhibits the reaction [Doxorubicin results in decreased expression of CAT mRNA]

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

C-C motif chemokine ligand 2

multiple interactions

EXP

esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of CCL2 protein]

NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279

G

cyclin D1

decreases expression

ISO

esculetin results in decreased expression of CCND1 protein

PMID:21600278 PMID:31313495

NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662

G

cyclin dependent kinase 2

decreases expression
multiple interactions

ISO

esculetin results in decreased expression of CDK2 protein
esculetin promotes the reaction [CDKN1A protein binds to CDK2 protein]; SB 203580 inhibits the reaction [esculetin results in decreased expression of CDK2 protein]

NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900

G

cyclin dependent kinase 4

decreases expression
multiple interactions

ISO

esculetin results in decreased expression of CDK4 protein
esculetin promotes the reaction [CDKN1A protein binds to CDK4 protein]; SB 203580 inhibits the reaction [esculetin results in decreased expression of CDK4 protein]

NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789

G

cyclin dependent kinase inhibitor 1A

multiple interactions
increases expression

ISO

esculetin promotes the reaction [CDKN1A protein binds to CDK2 protein]; esculetin promotes the reaction [CDKN1A protein binds to CDK4 protein]; SB 203580 inhibits the reaction [esculetin results in increased expression of CDKN1A protein]

PMID:21600278 PMID:31313495

NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701

G

cyclin dependent kinase inhibitor 1B

increases expression

ISO

esculetin results in increased expression of CDKN1B protein

NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476

G

catechol-O-methyltransferase

increases methylation

ISO

COMT protein results in increased methylation of esculetin

NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602

G

cytochrome c, somatic

multiple interactions

ISO

[arsenic trioxide co-treated with esculetin] affects the localization of CYCS protein; [esculetin co-treated with Paclitaxel] affects the localization of CYCS protein

PMID:16051289 PMID:19428345

NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518

G

Fas cell surface death receptor

multiple interactions

ISO

[esculetin co-treated with Paclitaxel] results in increased expression of FAS protein

NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172

G

Fas ligand

multiple interactions

ISO

[esculetin co-treated with Paclitaxel] results in increased expression of FASLG protein

NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064

G

fatty acid synthase

multiple interactions

EXP

esculetin promotes the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of FASN mRNA]

NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373

G

fibronectin 1

multiple interactions

ISO

esculetin inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]; esculetin inhibits the reaction [Streptozocin results in increased expression of FN1 protein]

NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions

EXP

esculetin promotes the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased activity of G6PC1 protein]

NCBI chr11:101,258,542...101,268,729
Ensembl chr11:101,258,387...101,268,729

G

interleukin 6

multiple interactions

EXP

esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL6 mRNA]; esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL6 protein]

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

mitogen-activated protein kinase 1

multiple interactions
increases phosphorylation

ISO

[esculetin co-treated with Paclitaxel] results in decreased expression of MAPK1 protein; esculetin results in decreased phosphorylation of and results in decreased activity of MAPK1 protein
esculetin results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [esculetin results in increased phosphorylation of MAPK1 protein]; SB 203580 inhibits the reaction [esculetin results in increased phosphorylation of MAPK1 protein]

PMID:16051289 PMID:21600278 PMID:24995577

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 14

multiple interactions

ISO

[esculetin co-treated with Paclitaxel] results in decreased expression of MAPK14 protein; esculetin results in decreased phosphorylation of and results in decreased activity of MAPK14 protein

NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380

G

mitogen-activated protein kinase 3

multiple interactions
increases phosphorylation

ISO

[esculetin co-treated with Paclitaxel] results in decreased expression of MAPK3 protein; esculetin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein
esculetin results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [esculetin results in increased phosphorylation of MAPK3 protein]; SB 203580 inhibits the reaction [esculetin results in increased phosphorylation of MAPK3 protein]

PMID:16051289 PMID:21600278 PMID:24995577

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

mitogen-activated protein kinase 8

multiple interactions
increases phosphorylation
increases expression

ISO

[esculetin co-treated with Paclitaxel] results in increased expression of MAPK8 protein
esculetin results in increased phosphorylation of MAPK8 protein
esculetin results in increased expression of MAPK8 protein

PMID:16051289 PMID:19786087

NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115

G

mitogen-activated protein kinase 9

multiple interactions
increases expression

ISO

[esculetin co-treated with Paclitaxel] results in increased expression of MAPK9 protein
esculetin results in increased expression of MAPK9 protein

NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248

G

matrix metallopeptidase 13

multiple interactions

ISO

esculetin inhibits the reaction [Streptozocin results in increased expression of MMP13 mRNA]

NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331

G

myeloid differentiation primary response gene 88

multiple interactions

EXP

esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of MYD88 mRNA]

NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477

G

nuclear factor, erythroid derived 2, like 2

increases localization
affects localization

ISO

esculetin results in increased localization of NFE2L2 protein
esculetin affects the localization of NFE2L2 protein

PMID:20933534 PMID:30171828

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105

affects localization

ISO

esculetin affects the localization of NFKB1 protein

NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308

G

nitric oxide synthase 2, inducible

multiple interactions

EXP

esculetin promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

nitric oxide synthase 3, endothelial cell

multiple interactions

ISO

esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NOS3 mRNA]; esculetin inhibits the reaction [Dietary Fats results in decreased expression of NOS3 mRNA]

NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472

G

NAD(P)H dehydrogenase, quinone 1

multiple interactions
increases expression

ISO

esculetin results in increased expression of and results in increased activity of NQO1 protein
esculetin results in increased expression of NQO1 mRNA

NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838

G

poly (ADP-ribose) polymerase family, member 1

increases cleavage

ISO

esculetin results in increased cleavage of PARP1 protein

PMID:26388407 PMID:31313495

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

G

peroxisome proliferator activated receptor gamma

multiple interactions

ISO
EXP

esculetin inhibits the reaction [Streptozocin results in decreased expression of PPARG protein]; esculetin inhibits the reaction [Streptozocin results in increased expression of PPARG protein]
esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PPARG mRNA]

PMID:21450970 PMID:27769711

NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

affects localization

ISO

esculetin affects the localization of RELA protein

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

superoxide dismutase 1, soluble

affects expression

ISO

esculetin affects the expression of SOD1 protein

NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217

G

trans-acting transcription factor 1

decreases expression

ISO

esculetin results in decreased expression of SP1 protein

NCBI chr15:102,314,751...102,344,839
Ensembl chr15:102,314,578...102,344,839

G

transforming growth factor, beta 1

multiple interactions

ISO

esculetin inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]

NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502

G

toll-like receptor 4

multiple interactions

EXP

esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TLR4 mRNA]

NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521

G

tumor necrosis factor

multiple interactions

EXP

esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TNF mRNA]; esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TNF protein]

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

tumor necrosis factor receptor superfamily, member 10b

increases expression

ISO

esculetin results in increased expression of TNFRSF10A protein

NCBI chr14:70,004,921...70,021,860
Ensembl chr14:70,004,921...70,021,860

G

transformation related protein 53

increases degradation
increases expression

ISO

esculetin results in increased degradation of TP53 protein
esculetin results in increased expression of TP53 protein

PMID:14634213 PMID:31313495

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

G

ubiquitin specific peptidase 16

multiple interactions

ISO

esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of USP16 mRNA]; esculetin inhibits the reaction [Dietary Fats results in increased expression of USP16 mRNA]

NCBI chr16:87,251,833...87,280,403
Ensembl chr16:87,251,591...87,280,405

G

ubiquitin specific peptidase 22

multiple interactions

ISO

esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of USP22 mRNA]; esculetin inhibits the reaction [Dietary Fats results in increased expression of USP22 mRNA]

NCBI chr11:61,042,607...61,065,885
Ensembl chr11:61,042,611...61,065,881

G

vascular cell adhesion molecule 1

multiple interactions

ISO

esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of VCAM1 mRNA]; esculetin inhibits the reaction [Dietary Fats results in increased expression of VCAM1 mRNA]

NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

RIKEN cDNA 1700016H13 gene

decreases expression

ISO

oxybenzone results in decreased expression of AFF1-AS1 mRNA

NCBI chr 5:103,796,449...103,803,898
Ensembl chr 5:103,795,905...103,803,876

G

acyl-Coenzyme A dehydrogenase family, member 10

increases expression

ISO

oxybenzone results in increased expression of ACAD10 mRNA

NCBI chr 5:121,759,089...121,798,642
Ensembl chr 5:121,759,089...121,798,577

G

acyl-Coenzyme A dehydrogenase family, member 9

increases expression

ISO

oxybenzone results in increased expression of ACAD9 mRNA

NCBI chr 3:36,120,128...36,147,006
Ensembl chr 3:36,120,128...36,147,002

G

acyl-Coenzyme A binding domain containing 3

decreases expression

ISO

oxybenzone results in decreased expression of ACBD3 mRNA

NCBI chr 1:180,553,608...180,581,769
Ensembl chr 1:180,553,608...180,581,769

G

acetylcholinesterase

decreases expression

EXP

oxybenzone results in decreased expression of ACHE mRNA

NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728

G

aconitase 2, mitochondrial

affects expression

ISO

oxybenzone affects the expression of ACO2 mRNA

NCBI chr15:81,756,664...81,799,338
Ensembl chr15:81,756,510...81,799,334

G

acyl-CoA thioesterase 2

increases expression

ISO

oxybenzone results in increased expression of ACOT2 mRNA

NCBI chr12:84,034,635...84,040,651
Ensembl chr12:84,034,635...84,040,647

G

acyl-Coenzyme A oxidase 1, palmitoyl

increases expression

ISO

oxybenzone results in increased expression of ACOX1 mRNA

NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871

G

acyl-CoA synthetase long-chain family member 5

decreases expression

ISO

oxybenzone results in decreased expression of ACSL5 mRNA

NCBI chr19:55,240,298...55,285,060
Ensembl chr19:55,240,370...55,286,152

G

acyl-CoA synthetase short-chain family member 2

increases expression

ISO

oxybenzone results in increased expression of ACSS2 mRNA

NCBI chr 2:155,359,963...155,404,663
Ensembl chr 2:155,359,868...155,427,644

G

activin A receptor, type II-like 1

decreases expression

EXP

oxybenzone results in decreased expression of ACVRL1 mRNA

NCBI chr15:101,026,403...101,043,217
Ensembl chr15:101,026,403...101,043,217

G

ADAM metallopeptidase with thrombospondin type 1 motif 1

decreases expression

EXP

oxybenzone results in decreased expression of ADAMTS1 mRNA

NCBI chr16:85,590,715...85,600,001
Ensembl chr16:85,590,715...85,600,001

G

adenylate cyclase 4

decreases expression

EXP

oxybenzone results in decreased expression of ADCY4 mRNA

NCBI chr14:56,006,513...56,021,552
Ensembl chr14:56,006,514...56,021,552

G

adiponectin, C1Q and collagen domain containing

multiple interactions

ISO

oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ mRNA]; oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ protein]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ mRNA]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ protein]

PMID:32407875 PMID:34864131

NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778

G

adenosine A2b receptor

decreases expression

EXP

oxybenzone results in decreased expression of ADORA2B mRNA

NCBI chr11:62,139,810...62,157,278
Ensembl chr11:62,139,810...62,157,279

G

ADP-ribosylhydrolase like 1

affects expression

ISO

oxybenzone affects the expression of ADPRHL1 mRNA

NCBI chr 8:13,268,449...13,304,079
Ensembl chr 8:13,271,663...13,304,162

G

aryl-hydrocarbon receptor

decreases expression
increases expression

ISO

oxybenzone results in decreased expression of AHR mRNA
oxybenzone results in increased expression of AHR protein

PMID:15458797 PMID:30099065

NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037

G

allograft inflammatory factor 1

increases expression

ISO

oxybenzone results in increased expression of AIF1 mRNA; oxybenzone results in increased expression of AIF1 protein

NCBI chr17:35,389,967...35,394,977
Ensembl chr17:35,389,967...35,395,044

G

thymoma viral proto-oncogene 3

increases expression

ISO

oxybenzone results in increased expression of AKT3 mRNA

NCBI chr 1:176,847,642...177,091,688
Ensembl chr 1:176,847,639...177,085,769

G

angiopoietin 1

multiple interactions

EXP

[oxybenzone co-treated with Dietary Fats analog] results in decreased expression of ANGPT1 mRNA

NCBI chr15:42,288,063...42,540,373
Ensembl chr15:42,288,119...42,540,373

G

angiopoietin 2

multiple interactions

EXP

[oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of ANGPT2 mRNA

NCBI chr 8:18,740,279...18,791,578
Ensembl chr 8:18,740,279...18,791,578

G

angiopoietin 4

multiple interactions

EXP

[oxybenzone co-treated with Dietary Fats analog] results in decreased expression of ANGPT4 mRNA

NCBI chr 2:151,753,127...151,787,257
Ensembl chr 2:151,753,130...151,787,257

G

angiopoietin-like 4

multiple interactions

EXP

[oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of ANGPTL4 mRNA

NCBI chr17:33,993,874...34,000,549
Ensembl chr17:33,992,724...34,000,804

G

APC, WNT signaling pathway regulator

increases expression
decreases expression

ISO

oxybenzone results in increased expression of APC mRNA
oxybenzone results in decreased expression of APC mRNA

PMID:36581016 PMID:39343157

NCBI chr18:34,353,350...34,455,243
Ensembl chr18:34,353,977...34,455,605

G

apelin

decreases expression

ISO

oxybenzone results in decreased expression of APLN mRNA

NCBI chr X:47,114,023...47,123,730
Ensembl chr X:47,114,023...47,123,730

G

apolipoprotein C-III

increases expression

ISO

oxybenzone results in increased expression of APOC3 mRNA

NCBI chr 9:46,144,348...46,146,934
Ensembl chr 9:46,144,231...46,146,934

G

apolipoprotein E

decreases expression

EXP

oxybenzone results in decreased expression of APOE mRNA

NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113

G

apolipoprotein L domain containing 1

decreases expression

EXP

oxybenzone results in decreased expression of APOLD1 mRNA

NCBI chr 6:134,958,964...134,963,799
Ensembl chr 6:134,958,681...134,963,799

G

aquaporin 1

decreases expression

ISO
EXP

oxybenzone results in decreased expression of AQP1 mRNA

PMID:30316929 PMID:39343157

NCBI chr 6:55,313,284...55,325,540
Ensembl chr 6:55,313,417...55,325,540

G

androgen receptor

multiple interactions
affects localization

ISO

oxybenzone binds to and results in decreased activity of AR protein; oxybenzone inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; oxybenzone inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]
oxybenzone affects the localization of AR protein

PMID:12730620 PMID:15537743 PMID:15950433 PMID:30099065 PMID:33049310

NCBI chr X:97,192,363...97,366,824
Ensembl chr X:97,192,375...97,366,821

G

amphiregulin

increases expression
decreases expression

ISO
EXP

oxybenzone results in increased expression of AREG mRNA
oxybenzone results in decreased expression of AREG mRNA

PMID:31939680 PMID:38382712

NCBI chr 5:91,287,458...91,296,291
Ensembl chr 5:91,287,458...91,296,291

G

activating transcription factor 2

increases expression

ISO

oxybenzone results in increased expression of ATF2 mRNA

NCBI chr 2:73,646,853...73,723,094
Ensembl chr 2:73,646,853...73,722,983

G

autophagy related 2B

increases expression

ISO

oxybenzone results in increased expression of ATG2B mRNA

NCBI chr12:105,579,798...105,651,554
Ensembl chr12:105,582,395...105,651,470

G

ataxia telangiectasia mutated

increases expression

ISO

oxybenzone results in increased expression of ATM mRNA

NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040

G

ATP synthase F1 subunit alpha

increases expression

ISO

oxybenzone results in increased expression of ATP5F1A mRNA

NCBI chr18:77,861,468...77,870,569
Ensembl chr18:77,861,429...77,870,569

G

ATP synthase F1 subunit beta

increases expression

ISO

oxybenzone results in increased expression of ATP5F1B mRNA

NCBI chr10:127,919,176...127,926,257
Ensembl chr10:127,919,142...127,926,260

G

ATP synthase F1 subunit gamma

increases expression

ISO

oxybenzone results in increased expression of ATP5F1C mRNA

NCBI chr 2:10,060,841...10,085,321
Ensembl chr 2:10,060,827...10,085,321

G

ATP synthase membrane subunit c locus 2

decreases expression

ISO

oxybenzone results in decreased expression of ATP5MC2 mRNA

NCBI chr15:102,571,303...102,579,482
Ensembl chr15:102,571,299...102,580,787

G

ataxia telangiectasia and Rad3 related

increases expression

ISO

oxybenzone results in increased expression of ATR mRNA

NCBI chr 9:95,739,655...95,834,813
Ensembl chr 9:95,739,650...95,833,834

G

BCL2-associated agonist of cell death

increases expression

ISO

oxybenzone results in increased expression of BAD mRNA

NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267

G

BCL2-antagonist/killer 1

increases expression

ISO

oxybenzone results in increased expression of BAK1 mRNA; oxybenzone results in increased expression of BAK1 protein

PMID:30099065 PMID:30316929

NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983

G

BCL2-associated X protein

increases expression

ISO

oxybenzone results in increased expression of BAX mRNA; oxybenzone results in increased expression of BAX protein

PMID:30099065 PMID:30316929

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

BCL2-like 1

decreases expression

ISO

oxybenzone results in decreased expression of BCL2L1 mRNA

NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648

G

BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone

increases expression

ISO

oxybenzone results in increased expression of BCS1L mRNA

NCBI chr 1:74,627,448...74,631,602
Ensembl chr 1:74,627,448...74,631,602

G

Bloom syndrome, RecQ like helicase

increases expression

ISO

oxybenzone results in increased expression of BLM mRNA

NCBI chr 7:80,104,839...80,184,896
Ensembl chr 7:80,104,481...80,184,867

G

breast cancer 1, early onset

increases expression

ISO

oxybenzone results in increased expression of BRCA1 mRNA

NCBI chr11:101,379,587...101,442,808
Ensembl chr11:101,379,590...101,442,781

G

calcium channel, voltage-dependent, alpha2/delta subunit 1

increases expression

ISO

oxybenzone results in increased expression of CACNA2D1 mRNA

NCBI chr 5:16,139,390...16,579,509
Ensembl chr 5:16,139,786...16,579,502

G

calreticulin

decreases expression

EXP

oxybenzone results in decreased expression of CALR mRNA

NCBI chr 8:85,568,717...85,573,560
Ensembl chr 8:85,568,479...85,573,563

G

caspase 1

decreases expression

ISO

oxybenzone results in decreased expression of CASP1 mRNA

NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290

G

caspase 2

increases expression

ISO

oxybenzone results in increased expression of CASP2 mRNA

NCBI chr 6:42,241,942...42,259,442
Ensembl chr 6:42,241,919...42,259,442

G

caspase 3

increases activity
multiple interactions

ISO

oxybenzone results in increased activity of CASP3 protein
oxybenzone results in increased expression of and results in increased activity of CASP3 protein

PMID:30099065 PMID:31368502

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 4, apoptosis-related cysteine peptidase

decreases expression

ISO

oxybenzone results in decreased expression of CASP4 mRNA

NCBI chr 9:5,308,816...5,336,791
Ensembl chr 9:5,308,828...5,336,783

G

caspase 9

increases activity
increases expression

ISO

oxybenzone results in increased activity of CASP9 protein
oxybenzone results in increased expression of CASP9 mRNA

PMID:30099065 PMID:30316929

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

C-C motif chemokine ligand 21 (serine)

decreases expression

ISO

oxybenzone results in decreased expression of CCL21 mRNA

NCBI chr 4:42,772,860...42,773,991
Ensembl chr 4:42,772,860...42,773,993

G

cyclin E2

increases expression

ISO

oxybenzone results in increased expression of CCNE2 mRNA

NCBI chr 4:11,190,489...11,204,781
Ensembl chr 4:11,191,351...11,204,779

G

cadherin 5

decreases expression

EXP

oxybenzone results in decreased expression of CDH5 mRNA

NCBI chr 8:104,828,247...104,871,136
Ensembl chr 8:104,828,257...104,871,143

G

conserved helix-loop-helix ubiquitous kinase

increases expression

ISO

oxybenzone results in increased expression of CHUK mRNA

NCBI chr19:44,061,773...44,095,940
Ensembl chr19:44,061,774...44,095,919

G

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4

increases expression

ISO

oxybenzone results in increased expression of CITED4 mRNA

NCBI chr 4:120,523,760...120,525,017
Ensembl chr 4:120,523,769...120,525,017

G

claudin 1

decreases expression

EXP

oxybenzone results in decreased expression of CLDN1 mRNA

NCBI chr16:26,175,395...26,190,589
Ensembl chr16:26,175,392...26,190,591

G

claudin 11

decreases expression

EXP

oxybenzone results in decreased expression of CLDN11 mRNA

NCBI chr 3:31,204,069...31,218,475
Ensembl chr 3:31,204,069...31,218,473

G

claudin 5

decreases expression

ISO
EXP

oxybenzone results in decreased expression of CLDN5 protein
oxybenzone results in decreased expression of CLDN5 mRNA

NCBI chr16:18,595,597...18,597,012
Ensembl chr16:18,595,597...18,597,012

G

C-type lectin domain family 14, member a

decreases expression

EXP

oxybenzone results in decreased expression of CLEC14A mRNA

NCBI chr12:58,311,506...58,316,044
Ensembl chr12:58,311,506...58,316,076

G

cytochrome c oxidase assembly protein 15

increases expression

ISO

oxybenzone results in increased expression of COX15 mRNA

NCBI chr19:43,721,693...43,741,439
Ensembl chr19:43,721,693...43,741,439

G

cytochrome c oxidase assembly protein 16

decreases expression

ISO

oxybenzone results in decreased expression of COX16 mRNA

NCBI chr12:81,405,626...81,531,911
Ensembl chr12:81,405,800...81,531,901

G

cytochrome c oxidase assembly protein 17, copper chaperone

increases expression

ISO

oxybenzone results in increased expression of COX17 mRNA

NCBI chr16:38,167,332...38,173,125
Ensembl chr16:38,167,353...38,182,659

G

cytochrome c oxidase assembly protein 18

increases expression

ISO

oxybenzone results in increased expression of COX18 mRNA

NCBI chr 5:90,362,583...90,371,828
Ensembl chr 5:90,362,583...90,371,860

G

cytochrome c oxidase subunit 5A

increases expression

ISO

oxybenzone results in increased expression of COX5A mRNA

NCBI chr 9:57,423,012...57,439,710
Ensembl chr 9:57,428,557...57,439,709

G

cytochrome c oxidase subunit 6B2

decreases expression

ISO

oxybenzone results in decreased expression of COX6B2 mRNA

NCBI chr 7:4,754,791...4,756,093
Ensembl chr 7:4,754,791...4,756,093

G

cytochrome c oxidase subunit 7A2

decreases expression

ISO

oxybenzone results in decreased expression of COX7A2 mRNA

NCBI chr 9:79,662,523...79,667,135
Ensembl chr 9:79,662,643...79,667,160

G

carnitine palmitoyltransferase 1b, muscle

increases expression

ISO

oxybenzone results in increased expression of CPT1B mRNA

NCBI chr15:89,300,608...89,310,065
Ensembl chr15:89,300,608...89,310,066

G

carnitine palmitoyltransferase 2

increases expression

ISO

oxybenzone results in increased expression of CPT2 mRNA

NCBI chr 4:107,761,179...107,780,786
Ensembl chr 4:107,761,178...107,780,807

G

carboxypeptidase X, M14 family member 2

decreases expression

ISO

oxybenzone results in decreased expression of CPXM2 mRNA

NCBI chr 7:131,634,416...131,756,483
Ensembl chr 7:131,634,416...131,756,468

G

cAMP responsive element binding protein 1

increases expression

ISO

oxybenzone results in increased expression of CREB1 mRNA

NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707

G

cAMP responsive element binding protein 3-like 1

decreases expression

EXP

oxybenzone results in decreased expression of CREB3L1 mRNA

NCBI chr 2:91,812,673...91,854,515
Ensembl chr 2:91,812,673...91,854,847

G

casein beta

decreases methylation
increases expression

EXP

oxybenzone results in decreased methylation of CSN2 promoter
oxybenzone results in increased expression of CSN2 mRNA; oxybenzone results in increased expression of CSN2 protein

NCBI chr 5:87,840,478...87,847,288
Ensembl chr 5:87,840,483...87,847,489

G

cystatin-like 1

decreases expression

ISO

oxybenzone results in decreased expression of CSTL1 mRNA

NCBI chr 2:148,592,272...148,597,354
Ensembl chr 2:148,592,278...148,597,353

G

catenin beta 1

decreases expression

ISO

oxybenzone results in decreased expression of CTNNB1 mRNA

NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573

G

cytochrome b reductase 1

increases expression

ISO

oxybenzone results in increased expression of CYBRD1 mRNA

NCBI chr 2:70,948,398...70,973,270
Ensembl chr 2:70,948,267...70,973,270

G

cytochrome P450, family 19, subfamily a, polypeptide 1

increases expression

ISO

oxybenzone results in increased expression of CYP19A1 mRNA

NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394

G

cytochrome P450, family 24, subfamily a, polypeptide 1

decreases expression

ISO

oxybenzone results in decreased expression of CYP24A1 mRNA

NCBI chr 2:170,324,877...170,339,065
Ensembl chr 2:170,324,628...170,339,065

G

cytochrome P450, family 26, subfamily c, polypeptide 1

increases expression

ISO

oxybenzone results in increased expression of CYP26C1 mRNA

NCBI chr19:37,673,560...37,681,774
Ensembl chr19:37,674,029...37,681,846

G

cytochrome P450, family 27, subfamily b, polypeptide 1

increases expression

ISO

oxybenzone results in increased expression of CYP27B1 mRNA

NCBI chr10:126,884,115...126,891,897
Ensembl chr10:126,884,119...126,888,875

G

cytochrome P450, family 2, subfamily b, polypeptide 10

decreases expression

ISO

oxybenzone results in decreased expression of CYP2B3 mRNA

NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049

G

cytochrome P450, family 4, subfamily f, polypeptide 18

increases expression

ISO

oxybenzone results in increased expression of CYP4F18 mRNA

NCBI chr 8:72,742,326...72,763,512
Ensembl chr 8:72,742,326...72,763,470

G

cytochrome P450, family 7, subfamily a, polypeptide 1

increases expression

ISO

oxybenzone results in increased expression of CYP7A1 mRNA

NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633

G

death-associated protein

decreases expression

ISO

oxybenzone results in decreased expression of DAP mRNA

NCBI chr15:31,224,531...31,274,484
Ensembl chr15:31,224,460...31,274,487

G

death-associated protein kinase 3

increases expression

ISO

oxybenzone results in increased expression of DAPK3 mRNA

NCBI chr10:81,018,821...81,029,031
Ensembl chr10:81,018,839...81,029,031

G

Fas death domain-associated protein

increases expression
increases methylation

ISO

oxybenzone results in increased expression of DAXX mRNA
oxybenzone results in increased methylation of DAXX gene

PMID:30316929 PMID:34523531

NCBI chr17:34,128,379...34,134,564
Ensembl chr17:34,128,388...34,134,564

G

death effector domain-containing

increases expression

ISO

oxybenzone results in increased expression of DEDD mRNA

NCBI chr 1:171,152,229...171,170,843
Ensembl chr 1:171,156,713...171,169,899

G

DNA fragmentation factor, alpha subunit

increases expression

ISO

oxybenzone results in increased expression of DFFA mRNA

NCBI chr 4:149,188,599...149,205,110
Ensembl chr 4:149,188,603...149,205,104

G

dihydroorotate dehydrogenase

increases expression

ISO

oxybenzone results in increased expression of DHODH mRNA

NCBI chr 8:110,319,876...110,335,330
Ensembl chr 8:110,317,975...110,335,305

G

dihydrolipoamide dehydrogenase

increases expression

ISO

oxybenzone results in increased expression of DLD mRNA

NCBI chr12:31,381,561...31,401,470
Ensembl chr12:31,381,276...31,401,452

G

delta like canonical Notch ligand 4

decreases expression

ISO
EXP

oxybenzone results in decreased expression of DLL4 mRNA

NCBI chr 2:119,156,286...119,166,145
Ensembl chr 2:119,156,265...119,166,443

G

dihydrolipoamide S-succinyltransferase

increases expression

ISO

oxybenzone results in increased expression of DLST mRNA

NCBI chr12:85,157,597...85,180,865
Ensembl chr12:85,157,607...85,181,619

G

distal-less homeobox 3

affects expression

ISO

oxybenzone affects the expression of DLX3 mRNA

NCBI chr11:95,010,943...95,016,122
Ensembl chr11:95,010,945...95,016,122

G

cyclin D binding myb like transcription factor 1

increases expression

ISO

oxybenzone results in increased expression of DMTF1 mRNA

NCBI chr 5:9,168,868...9,211,782
Ensembl chr 5:9,168,801...9,211,776

G

DnaJ heat shock protein family (Hsp40) member C15

decreases expression

ISO

oxybenzone results in decreased expression of DNAJC15 mRNA

NCBI chr14:78,063,657...78,112,357
Ensembl chr14:78,058,121...78,112,565

G

dipeptidylpeptidase 4

decreases expression

EXP

oxybenzone results in decreased expression of DPP4 mRNA

NCBI chr 2:62,160,417...62,242,635
Ensembl chr 2:62,160,417...62,242,575

G

dual specificity phosphatase 9

decreases expression

EXP

oxybenzone results in decreased expression of DUSP9 mRNA

NCBI chr X:72,682,995...72,687,120
Ensembl chr X:72,683,025...72,687,120

G

enoyl Coenzyme A hydratase, short chain, 1, mitochondrial

increases expression

ISO

oxybenzone results in increased expression of ECHS1 mRNA

NCBI chr 7:139,685,623...139,696,334
Ensembl chr 7:139,685,623...139,696,389

G

endothelin receptor type A

decreases expression

EXP

oxybenzone results in decreased expression of EDNRA mRNA

NCBI chr 8:78,389,658...78,451,081
Ensembl chr 8:78,389,660...78,451,093

G

EGF-like domain 7

decreases expression

EXP

oxybenzone results in decreased expression of EGFL7 mRNA

NCBI chr 2:26,471,095...26,482,694
Ensembl chr 2:26,470,026...26,483,132

G

early growth response 1

decreases expression

EXP

oxybenzone results in decreased expression of EGR1 mRNA

NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037

G

eukaryotic translation initiation factor 4E

increases expression

ISO

oxybenzone results in increased expression of EIF4E mRNA

NCBI chr 3:138,231,952...138,265,457
Ensembl chr 3:138,231,940...138,265,457

G

ENAH actin regulator

decreases expression

ISO

oxybenzone results in decreased expression of ENAH mRNA

NCBI chr 1:181,723,949...181,848,132
Ensembl chr 1:181,723,949...181,847,555

G

Eph receptor A1

decreases expression

EXP

oxybenzone results in decreased expression of EPHA1 mRNA

NCBI chr 6:42,335,421...42,350,249
Ensembl chr 6:42,335,421...42,350,202

G

estrogen receptor 1 (alpha)

decreases expression
increases expression
multiple interactions

ISO
EXP

oxybenzone results in decreased expression of ESR1 mRNA; oxybenzone results in decreased expression of ESR1 protein
oxybenzone results in increased expression of ESR1 mRNA
oxybenzone binds to and results in increased activity of ESR1 protein; oxybenzone promotes the reaction [ESR1 protein binds to ESR1 protein]

PMID:15458797 PMID:16079615 PMID:30099065 PMID:32946892 PMID:33049310 More...

NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614

G

estrogen receptor 2 (beta)

multiple interactions
affects expression
decreases expression

ISO

oxybenzone binds to and results in increased activity of ESR2 protein
oxybenzone affects the expression of ESR2 protein
oxybenzone results in decreased expression of ESR2 mRNA

PMID:16079615 PMID:30099065 PMID:33049310

NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033

G

estrogen related receptor, alpha

decreases expression

ISO

oxybenzone results in decreased expression of ESRRA mRNA

NCBI chr19:6,888,345...6,899,182
Ensembl chr19:6,888,345...6,899,208

G

F11 receptor

decreases expression

EXP

oxybenzone results in decreased expression of F11R mRNA

NCBI chr 1:171,265,129...171,292,161
Ensembl chr 1:171,265,103...171,292,171

G

fatty acid binding protein 4, adipocyte

multiple interactions

ISO

oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 mRNA]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA]

PMID:32407875 PMID:34864131

NCBI chr 3:10,269,406...10,273,653
Ensembl chr 3:10,269,148...10,273,636

G

family with sequence similarity 180, member A

decreases expression

ISO

oxybenzone results in decreased expression of FAM180A mRNA

NCBI chr 6:35,289,678...35,303,076
Ensembl chr 6:35,289,603...35,303,076

G

fibroblast growth factor 2

increases expression

ISO

oxybenzone results in increased expression of FGF2 mRNA

NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257

G

fibroblast growth factor receptor-like 1

decreases expression

EXP

oxybenzone results in decreased expression of FGFRL1 mRNA

NCBI chr 5:108,842,051...108,854,816
Ensembl chr 5:108,840,248...108,854,790

G

filaggrin

affects response to substance
multiple interactions

ISO

FLG gene mutant form affects the susceptibility to oxybenzone
[FLG gene mutant form affects the susceptibility to oxybenzone] which results in decreased secretion of FSHB protein; [FLG gene mutant form affects the susceptibility to oxybenzone] which results in increased secretion of Estradiol; [FLG gene mutant form affects the susceptibility to oxybenzone] which results in increased secretion of Testosterone

NCBI chr 3:93,180,853...93,200,996
Ensembl chr 3:93,180,830...93,200,993

G

Friend leukemia integration 1

decreases expression

EXP

oxybenzone results in decreased expression of FLI1 mRNA

NCBI chr 9:32,333,500...32,454,292
Ensembl chr 9:32,333,500...32,454,157

G

fibronectin 1

multiple interactions

EXP

[oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of FN1 mRNA

NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359

G

forkhead box C1

decreases expression

EXP

oxybenzone results in decreased expression of FOXC1 mRNA

NCBI chr13:31,990,629...31,994,618
Ensembl chr13:31,990,616...31,996,459

G

forkhead box L2

multiple interactions
increases expression

ISO

4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol inhibits the reaction [oxybenzone results in increased expression of FOXL2 mRNA]

NCBI chr 9:98,837,495...98,840,601
Ensembl chr 9:98,837,341...98,840,596

G

frizzled-related protein

decreases expression

ISO

oxybenzone results in decreased expression of FRZB mRNA

NCBI chr 2:80,242,314...80,277,740
Ensembl chr 2:80,242,314...80,277,969

G

follicle stimulating hormone beta

multiple interactions

ISO

[FLG gene mutant form affects the susceptibility to oxybenzone] which results in decreased secretion of FSHB protein

NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001

G

follistatin

increases expression

ISO

oxybenzone results in increased expression of FST mRNA

NCBI chr13:114,588,798...114,595,522
Ensembl chr13:114,588,826...114,595,487

G

gamma-aminobutyric acid type A receptor subunit alpha 1

increases expression

EXP

oxybenzone results in increased expression of GABRA1 mRNA

NCBI chr11:42,021,766...42,073,893
Ensembl chr11:42,021,766...42,073,757

G

glutamic acid decarboxylase 2

increases expression

EXP

oxybenzone results in increased expression of GAD2 mRNA

NCBI chr 2:22,512,262...22,583,889
Ensembl chr 2:22,512,217...22,583,886

G

golgi associated RAB2 interactor 1A

decreases expression

ISO

oxybenzone results in decreased expression of GARIN1A mRNA

NCBI chr 6:29,276,298...29,290,684
Ensembl chr 6:29,279,592...29,290,679

G

golgi associated RAB2 interactor 3

decreases expression

ISO

oxybenzone results in decreased expression of GARIN3 mRNA

NCBI chr11:46,295,555...46,298,812
Ensembl chr11:46,287,386...46,298,809

G

glial fibrillary acidic protein

increases expression

EXP

oxybenzone results in increased expression of GFAP mRNA

NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738

G

gap junction protein, alpha 4

decreases expression

EXP

oxybenzone results in decreased expression of GJA4 mRNA

NCBI chr 4:127,205,213...127,207,832
Ensembl chr 4:127,205,214...127,207,832

G

G protein-coupled estrogen receptor 1

affects expression

ISO

oxybenzone affects the expression of GPER1 protein

NCBI chr 5:139,408,905...139,413,555
Ensembl chr 5:139,408,906...139,413,555

G

gene regulated by estrogen in breast cancer protein

multiple interactions
increases expression

ISO

Fulvestrant inhibits the reaction [oxybenzone results in increased expression of GREB1 mRNA]

NCBI chr12:16,720,616...16,851,395
Ensembl chr12:16,720,616...16,850,887

G

gremlin 1, DAN family BMP antagonist

decreases expression

EXP

oxybenzone results in decreased expression of GREM1 mRNA

NCBI chr 2:113,579,020...113,588,993
Ensembl chr 2:113,576,509...113,588,991

G

glutamate receptor, ionotropic, NMDA1 (zeta 1)

affects expression

ISO

oxybenzone affects the expression of GRIN1 protein

NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199

G

glutamate receptor, ionotropic, NMDA2A (epsilon 1)

affects expression

ISO

oxybenzone affects the expression of GRIN2A protein

NCBI chr16:9,385,765...9,813,744
Ensembl chr16:9,385,762...9,813,424

G

granulin

decreases expression

EXP

oxybenzone results in decreased expression of GRN mRNA

NCBI chr11:102,321,333...102,327,635
Ensembl chr11:102,321,141...102,327,874

G

glycogen synthase kinase 3 beta

decreases expression

ISO

oxybenzone results in decreased expression of GSK3B mRNA

NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446

G

glutathione S-transferase, alpha 1 (Ya)

decreases expression

ISO

oxybenzone results in decreased expression of GSTA5 mRNA

NCBI chr 9:78,137,951...78,149,965
Ensembl chr 9:78,137,938...78,149,966

G

glutathione S-transferase, alpha 2 (Yc2)

decreases expression

ISO

oxybenzone results in decreased expression of GSTA2 mRNA

NCBI chr 9:78,238,300...78,254,474
Ensembl chr 9:78,238,300...78,263,070

G

glutathione S-transferase, mu 1

increases expression

ISO

oxybenzone results in increased expression of GSTM1 mRNA

NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289

G

glutathione S-transferase, pi 1

increases expression

ISO

oxybenzone results in increased expression of GSTP1 mRNA

NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985

G

glutathione S-transferase, theta 4

decreases expression

ISO

oxybenzone results in decreased expression of GSTT4 mRNA

NCBI chr10:75,650,777...75,658,405
Ensembl chr10:75,650,777...75,658,377

G

granzyme B

decreases expression

EXP

oxybenzone results in decreased expression of GZMB mRNA

NCBI chr14:56,496,293...56,499,791
Ensembl chr14:56,496,295...56,499,717

G

H2A.X variant histone

increases expression
multiple interactions

EXP
ISO

oxybenzone results in increased expression of H2AX protein modified form
Fulvestrant inhibits the reaction [oxybenzone results in increased expression of H2AX protein modified form]

NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha

decreases expression

ISO

oxybenzone results in decreased expression of HADHA mRNA

NCBI chr 5:30,324,421...30,359,978
Ensembl chr 5:30,323,302...30,360,160

G

histone deacetylase 1

increases expression

ISO

oxybenzone results in increased expression of HDAC1 protein

NCBI chr 4:129,409,897...129,436,516
Ensembl chr 4:129,409,897...129,436,506

G

histone deacetylase 2

increases expression

ISO

oxybenzone results in increased expression of HDAC2 protein

NCBI chr10:36,850,293...36,877,885
Ensembl chr10:36,850,540...36,877,885

G

histone deacetylase 9

increases expression

ISO

oxybenzone results in increased expression of HDAC9 mRNA

NCBI chr12:34,097,579...34,967,094
Ensembl chr12:34,097,579...34,967,094

G

hes family bHLH transcription factor 1

decreases expression

ISO

oxybenzone results in decreased expression of HES1 mRNA

NCBI chr16:29,883,259...29,886,614
Ensembl chr16:29,883,202...29,886,614

G

hairy/enhancer-of-split related with YRPW motif 1

decreases expression

EXP

oxybenzone results in decreased expression of HEY1 mRNA

NCBI chr 3:8,728,419...8,732,098
Ensembl chr 3:8,728,419...8,732,316

G

hypoxia inducible factor 1, alpha subunit

increases expression
multiple interactions

ISO
EXP

oxybenzone results in increased expression of HIF1A mRNA
[oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of HIF1A mRNA

PMID:36581016 PMID:38387520

NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304

G

helicase-like transcription factor

increases expression

ISO

oxybenzone results in increased expression of HLTF mRNA

NCBI chr 3:20,111,959...20,172,655
Ensembl chr 3:20,111,975...20,172,654

G

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

increases expression

ISO

oxybenzone results in increased expression of HMGCR mRNA

NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444

G

3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1

increases expression

ISO

oxybenzone results in increased expression of HMGCS1 mRNA

NCBI chr13:120,151,887...120,169,796
Ensembl chr13:120,151,915...120,169,796

G

3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2

decreases expression

ISO

oxybenzone results in decreased expression of HMGCS2 mRNA

NCBI chr 3:98,187,747...98,218,054
Ensembl chr 3:98,187,751...98,218,054

G

hydroxysteroid (17-beta) dehydrogenase 10

decreases expression

ISO

oxybenzone results in decreased expression of HSD17B10 mRNA

NCBI chr X:150,784,892...150,787,438
Ensembl chr X:150,784,841...150,787,438

G

hydroxysteroid dehydrogenase like 2

decreases expression

ISO

oxybenzone results in decreased expression of HSDL2 mRNA

NCBI chr 4:59,581,515...59,618,694
Ensembl chr 4:59,581,563...59,618,689

G

heat shock protein 90, alpha (cytosolic), class A member 1

increases expression

ISO

oxybenzone results in increased expression of HSP90AA1 mRNA

NCBI chr12:110,657,470...110,662,829
Ensembl chr12:110,657,039...110,669,162

G

hydroxylysine kinase 1

increases expression

ISO

oxybenzone results in increased expression of HYKK mRNA

NCBI chr 9:54,824,574...54,857,208
Ensembl chr 9:54,824,567...54,857,208

G

intercellular adhesion molecule 1

decreases expression
multiple interactions

EXP

oxybenzone results in decreased expression of ICAM1 mRNA
bisphenol A inhibits the reaction [oxybenzone results in decreased expression of ICAM1 mRNA]

NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113

G

inhibitor of DNA binding 3

decreases expression

EXP

oxybenzone results in decreased expression of ID3 mRNA

NCBI chr 4:135,871,133...135,872,703
Ensembl chr 4:135,870,808...135,873,066

G

isocitrate dehydrogenase 2 (NADP+), mitochondrial

decreases expression

ISO

oxybenzone results in decreased expression of IDH2 mRNA

NCBI chr 7:79,744,594...79,768,356
Ensembl chr 7:79,744,594...79,765,140

G

isocitrate dehydrogenase 3 (NAD+), gamma

increases expression

ISO

oxybenzone results in increased expression of IDH3G mRNA

NCBI chr X:72,822,569...72,830,471
Ensembl chr X:72,822,569...72,830,503

G

interleukin 19

increases expression

ISO

oxybenzone results in increased expression of IL19 mRNA

NCBI chr 1:130,860,393...130,873,194
Ensembl chr 1:130,860,393...130,867,852

G

insulin I

multiple interactions

ISO

oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ mRNA]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ protein]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA]

NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914

G

insulin II

multiple interactions

ISO

oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ mRNA]; oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ protein]; oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 mRNA]; oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of PPARG mRNA]

NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118

G

IQ motif containing F6

decreases expression

ISO

oxybenzone results in decreased expression of IQCF6 mRNA

NCBI chr 9:106,503,800...106,504,874
Ensembl chr 9:106,503,180...106,504,874

G

integrin alpha 4

increases expression

ISO

oxybenzone results in increased expression of ITGA4 mRNA

NCBI chr 2:79,084,767...79,163,458
Ensembl chr 2:79,085,770...79,163,467

G

integrin alpha 5 (fibronectin receptor alpha)

decreases expression

EXP

oxybenzone results in decreased expression of ITGA5 mRNA

NCBI chr15:103,252,713...103,275,218
Ensembl chr15:103,252,713...103,275,190

G

kinase insert domain protein receptor

decreases expression

EXP

oxybenzone results in decreased expression of KDR mRNA

NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118

G

Kruppel-like transcription factor 2 (lung)

decreases expression

EXP

oxybenzone results in decreased expression of KLF2 mRNA

NCBI chr 8:73,072,906...73,075,498
Ensembl chr 8:73,072,877...73,075,500

G

Kruppel-like transcription factor 4 (gut)

decreases expression

EXP

oxybenzone results in decreased expression of KLF4 mRNA

NCBI chr 4:55,527,137...55,536,984
Ensembl chr 4:55,527,143...55,532,466

G

Kirsten rat sarcoma viral oncogene homolog

increases expression

ISO

oxybenzone results in increased expression of KRAS mRNA

NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965

G

keratin 18

decreases expression

ISO

oxybenzone results in decreased expression of KRT18 mRNA

NCBI chr15:101,936,651...101,940,461
Ensembl chr15:101,936,615...101,940,462

G

lymphocyte protein tyrosine kinase

decreases expression

ISO

oxybenzone results in decreased expression of LCK mRNA

NCBI chr 4:129,442,142...129,467,415
Ensembl chr 4:129,442,137...129,467,434

G

lipocalin 2

decreases expression

EXP

oxybenzone results in decreased expression of LCN2 mRNA

NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264

G

lactate dehydrogenase D

increases methylation

ISO

oxybenzone results in increased methylation of LDHD gene

NCBI chr 8:112,352,250...112,356,968
Ensembl chr 8:112,350,417...112,357,006

G

lymphoid enhancer binding factor 1

multiple interactions

EXP

[oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of LEF1 mRNA

NCBI chr 3:130,903,972...131,018,006
Ensembl chr 3:130,904,120...131,018,005

G

LIF receptor alpha

increases expression

ISO

oxybenzone results in increased expression of LIFR mRNA

NCBI chr15:7,120,091...7,226,970
Ensembl chr15:7,120,095...7,226,970

G

lysyl oxidase-like 1

decreases expression

EXP

oxybenzone results in decreased expression of LOXL1 mRNA

NCBI chr 9:58,195,006...58,220,495
Ensembl chr 9:58,195,021...58,220,469

G

leucine-rich single-pass membrane protein 1

increases expression

ISO

oxybenzone results in increased expression of LSMEM1 mRNA

NCBI chr12:40,226,385...40,249,314
Ensembl chr12:40,225,492...40,249,489

G

MAGE family member L2

increases expression

ISO

oxybenzone results in increased expression of MAGEL2 mRNA

NCBI chr 7:62,026,727...62,031,388
Ensembl chr 7:62,026,758...62,031,388

G

monoamine oxidase B

decreases expression

EXP

oxybenzone results in decreased expression of MAOB mRNA

NCBI chr X:16,575,520...16,683,605
Ensembl chr X:16,575,521...16,683,605

G

mitogen-activated protein kinase kinase 1

decreases expression

EXP

oxybenzone results in decreased expression of MAP2K1 mRNA

NCBI chr 9:64,093,066...64,160,887
Ensembl chr 9:64,093,052...64,160,913

G

mitogen-activated protein kinase kinase 3

decreases expression

EXP

oxybenzone results in decreased expression of MAP2K3 mRNA

NCBI chr11:60,822,880...60,843,637
Ensembl chr11:60,822,859...60,843,637

G

mitogen-activated protein kinase 6

increases expression

ISO

oxybenzone results in increased expression of MAPK6 mRNA

NCBI chr 9:75,294,064...75,317,303
Ensembl chr 9:75,276,344...75,317,287

G

mutated in colorectal cancers

decreases expression

ISO

oxybenzone results in decreased expression of MCC mRNA

NCBI chr18:44,558,127...44,945,573
Ensembl chr18:44,558,127...44,945,249

G

mediator complex subunit 13

increases expression

ISO

oxybenzone results in increased expression of MED13 mRNA

NCBI chr11:86,157,859...86,248,422
Ensembl chr11:86,157,859...86,248,428

G

mesenteric estrogen dependent adipogenesis

decreases expression

ISO

oxybenzone results in decreased expression of MEDAG mRNA

NCBI chr 5:149,335,214...149,355,188
Ensembl chr 5:149,335,214...149,355,188

G

matrix Gla protein

decreases expression

EXP

oxybenzone results in decreased expression of MGP mRNA

NCBI chr 6:136,849,433...136,852,821
Ensembl chr 6:136,849,433...136,852,821

G

Mov10 RISC complex RNA helicase

decreases expression

EXP

oxybenzone results in decreased expression of MOV10 mRNA

NCBI chr 3:104,702,144...104,725,935
Ensembl chr 3:104,702,152...104,725,879

G

metallophosphoesterase domain containing 2

increases expression

EXP

oxybenzone results in increased expression of MPPED2 mRNA

NCBI chr 2:106,523,526...106,699,684
Ensembl chr 2:106,523,614...106,698,701

G

MRE11A homolog A, double strand break repair nuclease

increases expression

ISO

oxybenzone results in increased expression of MRE11 mRNA

NCBI chr 9:14,695,971...14,748,421
Ensembl chr 9:14,695,950...14,748,419

G

mutS homolog 2

increases expression

ISO

oxybenzone results in increased expression of MSH2 mRNA

NCBI chr17:87,979,960...88,031,141
Ensembl chr17:87,979,758...88,031,141

G

myeloblastosis oncogene-like 1

multiple interactions
increases expression

ISO

Fulvestrant inhibits the reaction [oxybenzone results in increased expression of MYBL1 mRNA]

NCBI chr 1:9,737,632...9,770,664
Ensembl chr 1:9,737,640...9,770,434

G

v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived

increases expression

EXP

oxybenzone results in increased expression of MYCN mRNA

NCBI chr12:12,986,094...12,991,837
Ensembl chr12:12,986,094...12,991,915

G

NBL1, DAN family BMP antagonist

increases expression
decreases expression

EXP

oxybenzone results in increased expression of NBL1 mRNA
oxybenzone results in decreased expression of NBL1 mRNA

NCBI chr 4:138,809,602...138,820,437
Ensembl chr 4:138,809,595...138,820,304

G

nibrin

increases expression

ISO

oxybenzone results in increased expression of NBN mRNA

NCBI chr 4:15,955,388...15,992,589
Ensembl chr 4:15,957,925...15,992,589

G

nuclear receptor coactivator 2

multiple interactions
increases expression

ISO

oxybenzone promotes the reaction [NCOA2 protein binds to PPARG protein]
oxybenzone results in increased expression of NCOA2 mRNA

PMID:32407875 PMID:36581016

NCBI chr 1:13,209,329...13,444,451
Ensembl chr 1:13,209,329...13,444,307

G

NADH:ubiquinone oxidoreductase subunit A11

decreases expression

ISO

oxybenzone results in decreased expression of NDUFA11 mRNA

NCBI chr17:57,024,762...57,031,248
Ensembl chr17:57,024,767...57,029,141

G

NADH:ubiquinone oxidoreductase subunit A3

decreases expression

ISO

oxybenzone results in decreased expression of NDUFA3 mRNA

NCBI chr 7:3,620,372...3,623,162
Ensembl chr 7:3,620,372...3,623,326

G

NADH:ubiquinone oxidoreductase subunit A9

increases expression

ISO

oxybenzone results in increased expression of NDUFA9 mRNA

NCBI chr 6:126,798,826...126,826,107
Ensembl chr 6:126,798,684...126,826,099

G

NADH:ubiquinone oxidoreductase subunit AB1

increases expression

ISO

oxybenzone results in increased expression of NDUFAB1 mRNA

NCBI chr 7:121,686,038...121,701,071
Ensembl chr 7:121,684,626...121,701,109

G

NADH:ubiquinone oxidoreductase subunit B10

increases expression

ISO

oxybenzone results in increased expression of NDUFB10 mRNA

NCBI chr17:24,941,034...24,943,397
Ensembl chr17:24,941,034...24,943,452

G

NADH:ubiquinone oxidoreductase subunit B7

increases expression

ISO

oxybenzone results in increased expression of NDUFB7 mRNA

NCBI chr 8:84,293,387...84,298,252
Ensembl chr 8:84,293,300...84,298,255

G

NADH:ubiquinone oxidoreductase core subunit S2

decreases expression

ISO

oxybenzone results in decreased expression of NDUFS2 mRNA

NCBI chr 1:171,062,426...171,078,956
Ensembl chr 1:171,062,422...171,078,957
Ensembl chr 1:171,062,422...171,078,957

G

NADH:ubiquinone oxidoreductase core subunit V3

affects expression

ISO

oxybenzone affects the expression of NDUFV3 mRNA

NCBI chr17:31,739,089...31,750,300
Ensembl chr17:31,739,089...31,750,305

G

nestin

decreases expression

EXP

oxybenzone results in decreased expression of NES protein

NCBI chr 3:87,878,400...87,887,758
Ensembl chr 3:87,878,385...87,887,758

G

neurofibromin 1

increases expression

ISO

oxybenzone results in increased expression of NF1 mRNA

NCBI chr11:79,223,541...79,472,435
Ensembl chr11:79,230,519...79,472,438

G

nuclear factor of activated T cells 5

increases expression

ISO

oxybenzone results in increased expression of NFAT5 mRNA

NCBI chr 8:108,020,072...108,106,149
Ensembl chr 8:108,020,102...108,106,149

G

nuclear factor I/A

increases expression

EXP

oxybenzone results in increased expression of NFIA mRNA

NCBI chr 4:97,469,534...98,007,113
Ensembl chr 4:97,660,971...98,007,111

G

nuclear factor I/B

increases expression

EXP

oxybenzone results in increased expression of NFIB mRNA

NCBI chr 4:82,208,410...82,424,988
Ensembl chr 4:82,208,410...82,623,987

G

neutrophilic granule protein

decreases expression

EXP

oxybenzone results in decreased expression of NGP mRNA

NCBI chr 9:110,248,876...110,252,080
Ensembl chr 9:110,248,815...110,252,080

G

NK2 homeobox 2

increases expression

EXP

oxybenzone results in increased expression of NKX2-2 mRNA

NCBI chr 2:146,967,909...147,037,270
Ensembl chr 2:147,019,466...147,036,163

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

ISO
EXP

oxybenzone binds to and results in increased activity of NR1I2 protein

NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186

G

nuclear receptor subfamily 1, group I, member 3

increases activity

ISO

oxybenzone results in increased activity of NR1I3 protein

NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270

G

nuclear receptor subfamily 2, group F, member 6

increases expression
decreases expression

EXP

oxybenzone results in increased expression of NR2F6 mRNA
oxybenzone results in decreased expression of NR2F6 mRNA

NCBI chr 8:71,826,762...71,834,593
Ensembl chr 8:71,826,767...71,834,604

G

nuclear receptor subfamily 3, group C, member 1

increases expression

ISO

oxybenzone results in increased expression of NR3C1 mRNA

NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474

G

nuclear receptor subfamily 4, group A, member 1

decreases expression

EXP

oxybenzone results in decreased expression of NR4A1 mRNA

NCBI chr15:101,151,783...101,172,676
Ensembl chr15:101,152,150...101,172,676

G

Notch-regulated ankyrin repeat protein

decreases expression

ISO

oxybenzone results in decreased expression of NRARP mRNA

NCBI chr 2:25,070,770...25,073,351
Ensembl chr 2:25,070,770...25,073,351

G

nuclear respiratory factor 1

increases expression

ISO

oxybenzone results in increased expression of NRF1 mRNA

NCBI chr 6:30,047,984...30,153,462
Ensembl chr 6:30,047,987...30,153,457

G

neuregulin 1

increases expression

EXP

oxybenzone results in increased expression of NRG1 mRNA

NCBI chr 8:32,299,493...33,381,858
Ensembl chr 8:32,304,579...33,374,825

G

nuclear receptor interacting protein 1

increases expression

ISO

oxybenzone results in increased expression of NRIP1 mRNA

NCBI chr16:76,084,291...76,170,930
Ensembl chr16:76,084,288...76,170,715

G

neuropilin 1

decreases expression

ISO

oxybenzone results in decreased expression of NRP1 mRNA

NCBI chr 8:129,085,553...129,231,957
Ensembl chr 8:129,085,085...129,229,844

G

netrin 5

increases expression

ISO

oxybenzone results in increased expression of NTN5 mRNA

NCBI chr 7:45,333,519...45,343,980
Ensembl chr 7:45,333,446...45,343,980

G

occludin

decreases expression

EXP

oxybenzone results in decreased expression of OCLN mRNA

NCBI chr13:100,633,012...100,689,226
Ensembl chr13:100,633,015...100,689,226

G

oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)

increases expression
decreases expression

ISO

oxybenzone results in increased expression of OGDH mRNA
oxybenzone results in decreased expression of OGDH mRNA

NCBI chr11:6,241,597...6,309,094
Ensembl chr11:6,241,633...6,306,642

G

programmed cell death 11

increases expression

ISO

oxybenzone results in increased expression of PDCD11 mRNA

NCBI chr19:47,079,183...47,119,585
Ensembl chr19:47,079,207...47,120,304

G

programmed cell death 6 interacting protein

decreases expression

ISO

oxybenzone results in decreased expression of PDCD6IP mRNA

NCBI chr 9:113,480,812...113,537,457
Ensembl chr 9:113,480,812...113,537,327

G

programmed cell death 7

increases expression

ISO

oxybenzone results in increased expression of PDCD7 mRNA

NCBI chr 9:65,253,350...65,266,925
Ensembl chr 9:65,253,386...65,266,925

G

platelet derived growth factor, B polypeptide

decreases expression

EXP

oxybenzone results in decreased expression of PDGFB mRNA

NCBI chr15:79,880,066...79,899,178
Ensembl chr15:79,880,075...79,899,178

G

platelet derived growth factor receptor, alpha polypeptide

decreases expression

EXP

oxybenzone results in decreased expression of PDGFRA mRNA

NCBI chr 5:75,311,988...75,358,867
Ensembl chr 5:75,312,953...75,358,876

G

platelet/endothelial cell adhesion molecule 1

decreases expression

EXP

oxybenzone results in decreased expression of PECAM1 protein

NCBI chr11:106,545,039...106,606,107
Ensembl chr11:106,545,043...106,641,454

G

progesterone receptor

multiple interactions
decreases expression
increases expression

ISO
EXP

oxybenzone binds to and results in decreased activity of PGR protein
oxybenzone results in decreased expression of PGR mRNA
oxybenzone results in increased expression of PGR mRNA

PMID:15537743 PMID:31939680 PMID:32946892 PMID:38382712 PMID:38431166

NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612

G

PHD finger protein 24

increases expression

ISO

oxybenzone results in increased expression of PHF24 mRNA

NCBI chr 4:42,872,619...42,944,752
Ensembl chr 4:42,916,660...42,944,752

G

paired-like homeobox 2b

decreases expression

EXP

oxybenzone results in decreased expression of PHOX2B mRNA

NCBI chr 5:67,251,751...67,256,399
Ensembl chr 5:67,251,742...67,256,644

G

protein inhibitor of activated STAT 1

increases expression

ISO

oxybenzone results in increased expression of PIAS1 mRNA

NCBI chr 9:62,785,648...62,888,161
Ensembl chr 9:62,785,650...62,895,206

G

phosphoinositide-3-kinase regulatory subunit 1

increases expression

ISO

oxybenzone results in increased expression of PIK3R1 mRNA

NCBI chr13:101,817,269...101,904,725
Ensembl chr13:101,817,071...101,904,725

G

phosphoinositide-3-kinase regulatory subunit 5

decreases expression

EXP

oxybenzone results in decreased expression of PIK3R5 mRNA

NCBI chr11:68,322,951...68,388,675
Ensembl chr11:68,322,947...68,388,675

G

phospholipase D2

decreases expression

EXP

oxybenzone results in decreased expression of PLD2 mRNA

NCBI chr11:70,430,318...70,448,936
Ensembl chr11:70,430,890...70,448,936

G

plexin B3

decreases expression

EXP

oxybenzone results in decreased expression of PLXNB3 mRNA

NCBI chr X:72,800,564...72,816,116
Ensembl chr X:72,800,696...72,816,120

G

polymerase (DNA directed), mu

decreases expression

ISO

oxybenzone results in decreased expression of POLM mRNA

NCBI chr11:5,777,860...5,788,831
Ensembl chr11:5,777,860...5,788,016

G

peroxisome proliferator activated receptor alpha

increases expression

ISO

oxybenzone results in increased expression of PPARA mRNA

NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020

G

peroxisome proliferator activated receptor gamma

increases expression
multiple interactions
affects binding

ISO
EXP

oxybenzone results in increased expression of PPARG mRNA
oxybenzone binds to and results in increased activity of PPARG protein
oxybenzone binds to and results in increased activity of PPARG protein; oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of PPARG mRNA]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA]; oxybenzone promotes the reaction [NCOA2 protein binds to PPARG protein]
oxybenzone binds to PPARG protein

PMID:32407875 PMID:33049310 PMID:34864131

NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360

G

protein phosphatase 1 catalytic subunit beta

increases expression

ISO

oxybenzone results in increased expression of PPP1CB mRNA

NCBI chr 5:32,616,192...32,651,057
Ensembl chr 5:32,616,187...32,674,777

G

prickle planar cell polarity protein 1

decreases expression

EXP

oxybenzone results in decreased expression of PRICKLE1 mRNA

NCBI chr15:93,396,992...93,494,147
Ensembl chr15:93,396,995...93,493,772

G

protein kinase, cAMP dependent, catalytic, beta

increases expression

ISO

oxybenzone results in increased expression of PRKACB mRNA

NCBI chr 3:146,435,334...146,518,691
Ensembl chr 3:146,435,329...146,518,745

G

protein kinase C, iota

increases expression

ISO

oxybenzone results in increased expression of PRKCI mRNA

NCBI chr 3:31,049,893...31,106,889
Ensembl chr 3:31,049,896...31,107,108

G

serine protease 37

decreases expression

ISO

oxybenzone results in decreased expression of PRSS37 mRNA

NCBI chr 6:40,491,757...40,496,418
Ensembl chr 6:40,491,758...40,496,442

G

phosphatase and tensin homolog

increases expression

ISO

oxybenzone results in increased expression of PTEN mRNA

NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560

G

prostaglandin-endoperoxide synthase 2

increases expression

ISO

oxybenzone results in increased expression of PTGS2 mRNA

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

protein tyrosine phosphatase, non-receptor type 4

increases expression

ISO

oxybenzone results in increased expression of PTPN4 mRNA

NCBI chr 1:119,580,197...119,765,281
Ensembl chr 1:119,580,197...119,765,343

G

RAD17 checkpoint clamp loader component

increases expression

ISO

oxybenzone results in increased expression of RAD17 mRNA

NCBI chr13:100,753,672...100,787,569
Ensembl chr13:100,753,672...100,787,559

G

RAD50 double strand break repair protein

increases expression

ISO

oxybenzone results in increased expression of RAD50 mRNA

NCBI chr11:53,540,346...53,598,146
Ensembl chr11:53,540,346...53,598,146

G

RAS related protein 2a

increases expression

ISO

oxybenzone results in increased expression of RAP2A mRNA

NCBI chr14:120,715,873...120,744,606
Ensembl chr14:120,715,856...120,744,606

G

retinoic acid receptor, alpha

decreases expression

EXP

oxybenzone results in decreased expression of RARA mRNA

NCBI chr11:98,818,626...98,865,768
Ensembl chr11:98,818,644...98,865,768

G

RB transcriptional corepressor 1

increases expression

ISO

oxybenzone results in increased expression of RB1 mRNA

NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262

G

RB1-inducible coiled-coil 1

increases expression

ISO

oxybenzone results in increased expression of RB1CC1 mRNA

NCBI chr 1:6,284,858...6,346,599
Ensembl chr 1:6,276,421...6,346,872

G

retinoblastoma binding protein 8, endonuclease

increases expression

ISO

oxybenzone results in increased expression of RBBP8 mRNA

NCBI chr18:11,766,333...11,876,264
Ensembl chr18:11,766,333...11,878,278

G

RB transcriptional corepressor like 1

increases expression

ISO

oxybenzone results in increased expression of RBL1 mRNA

NCBI chr 2:156,987,813...157,046,454
Ensembl chr 2:156,987,813...157,046,454

G

reticuloendotheliosis oncogene

increases expression

ISO

oxybenzone results in increased expression of REL mRNA

NCBI chr11:23,686,847...23,720,969
Ensembl chr11:23,686,847...23,720,970

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

increases expression

ISO

oxybenzone results in increased expression of RELA protein

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

resistin

decreases expression

ISO

oxybenzone results in decreased expression of RETN mRNA

NCBI chr 8:3,705,770...3,709,818
Ensembl chr 8:3,705,770...3,710,110

G

replication factor C (activator 1) 1

increases expression

ISO

oxybenzone results in increased expression of RFC1 mRNA

NCBI chr 5:65,419,195...65,492,988
Ensembl chr 5:65,419,193...65,493,013

G

RPTOR independent companion of MTOR, complex 2

increases expression

ISO

oxybenzone results in increased expression of RICTOR mRNA

NCBI chr15:6,737,827...6,829,882
Ensembl chr15:6,737,860...6,829,882

G

regulating synaptic membrane exocytosis 2

increases expression

EXP

oxybenzone results in increased expression of RIMS2 mRNA

NCBI chr15:39,061,681...39,547,768
Ensembl chr15:39,061,656...39,547,768

G

roundabout guidance receptor 4

decreases expression

EXP

oxybenzone results in decreased expression of ROBO4 mRNA

NCBI chr 9:37,313,198...37,325,319
Ensembl chr 9:37,313,193...37,326,411

G

Rho-associated coiled-coil containing protein kinase 1

increases expression

ISO

oxybenzone results in increased expression of ROCK1 mRNA

NCBI chr18:10,064,401...10,182,225
Ensembl chr18:10,064,401...10,182,045

G

Rho-associated coiled-coil containing protein kinase 2

increases expression

ISO

oxybenzone results in increased expression of ROCK2 mRNA

NCBI chr12:16,944,808...17,038,275
Ensembl chr12:16,944,896...17,037,824

G

ribosomal protein S6 kinase, polypeptide 1

increases expression

ISO

oxybenzone results in increased expression of RPS6KB1 mRNA

NCBI chr11:86,389,695...86,435,711
Ensembl chr11:86,389,697...86,435,631

G

ribonucleotide reductase M2 B (TP53 inducible)

increases expression

ISO

oxybenzone results in increased expression of RRM2B mRNA

NCBI chr15:37,924,196...37,961,562
Ensembl chr15:37,924,196...37,961,562

G

succinate dehydrogenase complex, subunit A, flavoprotein (Fp)

increases expression

ISO

oxybenzone results in increased expression of SDHA mRNA

NCBI chr13:74,470,374...74,498,359
Ensembl chr13:74,470,373...74,498,399

G

serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1

increases expression

ISO

oxybenzone results in increased expression of SERPINC1 mRNA

NCBI chr 1:160,806,153...160,830,113
Ensembl chr 1:160,806,155...160,833,433

G

serine (or cysteine) peptidase inhibitor, clade E, member 2

increases expression

EXP

oxybenzone results in increased expression of SERPINE2 mRNA

NCBI chr 1:79,772,038...79,836,382
Ensembl chr 1:79,771,914...79,838,897

G

serum/glucocorticoid regulated kinase 1

increases expression
multiple interactions

ISO

oxybenzone results in increased expression of SGK1 mRNA
Fulvestrant inhibits the reaction [oxybenzone results in increased expression of SGK1 mRNA]

NCBI chr10:21,758,083...21,875,802
Ensembl chr10:21,758,083...21,875,802

G

SH3-domain binding protein 1

decreases expression

EXP

oxybenzone results in decreased expression of SH3BP1 mRNA

NCBI chr15:78,783,994...78,796,247
Ensembl chr15:78,783,968...78,796,251

G

SH3-domain GRB2-like B1 (endophilin)

increases expression

ISO

oxybenzone results in increased expression of SH3GLB1 mRNA

NCBI chr 3:144,389,426...144,426,186
Ensembl chr 3:144,389,439...144,426,096

G

SH3 and multiple ankyrin repeat domains 1

increases expression

ISO

oxybenzone results in increased expression of SHANK1 mRNA

NCBI chr 7:43,958,343...44,009,518
Ensembl chr 7:43,959,677...44,009,996

G

solute carrier family 18 (vesicular monoamine), member 2

increases expression

EXP

oxybenzone results in increased expression of SLC18A2 mRNA

NCBI chr19:59,249,310...59,284,444
Ensembl chr19:59,249,328...59,284,444

G

solute carrier family 1 (glial high affinity glutamate transporter), member 2

affects expression

ISO

oxybenzone affects the expression of SLC1A2 protein

NCBI chr 2:102,488,584...102,621,129
Ensembl chr 2:102,489,004...102,621,129

G

solute carrier family 6 (neurotransmitter transporter, GABA), member 1

increases expression

EXP

oxybenzone results in increased expression of SLC6A1 mRNA

NCBI chr 6:114,259,735...114,294,491
Ensembl chr 6:114,259,596...114,294,493

G

solute carrier family 7 (cationic amino acid transporter, y+ system), member 11

affects expression

ISO

oxybenzone affects the expression of SLC7A11 protein

NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063

G

SMAD family member 9

decreases expression

EXP

oxybenzone results in decreased expression of SMAD9 mRNA

NCBI chr 3:54,662,873...54,709,162
Ensembl chr 3:54,663,003...54,708,678

G

structural maintenance of chromosomes 3

increases expression

ISO

oxybenzone results in increased expression of SMC3 mRNA

NCBI chr19:53,588,827...53,634,262
Ensembl chr19:53,588,829...53,634,264

G

SRY (sex determining region Y)-box 18

decreases expression

EXP

oxybenzone results in decreased expression of SOX18 mRNA

NCBI chr 2:181,311,630...181,313,433
Ensembl chr 2:181,311,629...181,313,433

G

SRY (sex determining region Y)-box 9

multiple interactions
increases expression

ISO

4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol inhibits the reaction [oxybenzone results in increased expression of SOX9 mRNA]

NCBI chr11:112,673,036...112,678,583
Ensembl chr11:112,673,050...112,678,586

G

somatostatin receptor 3

increases expression

ISO

oxybenzone results in increased expression of SSTR3 mRNA

NCBI chr15:78,421,214...78,433,565
Ensembl chr15:78,421,208...78,428,885

G

STAG1 cohesin complex component

increases expression

ISO

oxybenzone results in increased expression of STAG1 mRNA

NCBI chr 9:100,479,762...100,840,597
Ensembl chr 9:100,479,851...100,841,428

G

signal transducer and activator of transcription 5A

affects localization
increases expression

EXP

oxybenzone affects the localization of STAT5A protein
oxybenzone results in increased expression of STAT5A mRNA

NCBI chr11:100,750,177...100,775,995
Ensembl chr11:100,750,177...100,775,995

G

TATA-box binding protein associated factor 9B

increases expression

ISO

oxybenzone results in increased expression of TAF9B mRNA

NCBI chr X:105,250,480...105,264,764
Ensembl chr X:105,250,489...105,264,764

G

TANK-binding kinase 1

increases expression

ISO

oxybenzone results in increased expression of TBK1 mRNA

NCBI chr10:121,382,360...121,422,699
Ensembl chr10:121,382,360...121,422,692

G

transcription factor 7 like 2, T cell specific, HMG box

increases expression

EXP

oxybenzone results in increased expression of TCF7L2 mRNA

NCBI chr19:55,730,227...55,922,091
Ensembl chr19:55,730,252...55,922,086

G

TEK receptor tyrosine kinase

decreases expression

EXP

oxybenzone results in decreased expression of TEK mRNA

NCBI chr 4:94,627,322...94,763,213
Ensembl chr 4:94,627,526...94,763,213

G

testis expressed 46

decreases expression

ISO

oxybenzone results in decreased expression of TEX46 mRNA

NCBI chr 4:136,334,313...136,340,590
Ensembl chr 4:136,337,748...136,340,537
Ensembl chr 4:136,337,748...136,340,537

G

transcription factor A, mitochondrial

increases expression

ISO

oxybenzone results in increased expression of TFAM mRNA

PMID:30316929 PMID:36581016

NCBI chr10:71,061,298...71,074,157
Ensembl chr10:71,061,294...71,074,110

G

trefoil factor 1

multiple interactions
increases expression

ISO

[oxybenzone co-treated with 2,4-dihydroxybenzophenone co-treated with octylmethoxycinnamate co-treated with enzacamene] results in increased expression of TFF1 mRNA; [oxybenzone co-treated with 2,4-dihydroxybenzophenone] results in increased expression of TFF1 mRNA
oxybenzone results in increased expression of TFF1 mRNA

NCBI chr17:31,380,369...31,384,034
Ensembl chr17:31,380,369...31,384,251

G

transforming growth factor, beta 1

multiple interactions

EXP

[oxybenzone co-treated with Dietary Fats analog] results in decreased expression of TGFB1 mRNA; [oxybenzone co-treated with Dietary Fats] results in decreased expression of TGFB1 mRNA

NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502

G

transforming growth factor, beta receptor I

increases expression

ISO

oxybenzone results in increased expression of TGFBR1 mRNA

NCBI chr 4:47,353,258...47,414,926
Ensembl chr 4:47,353,222...47,414,931

G

tissue inhibitor of metalloproteinase 1

decreases expression
multiple interactions

EXP

oxybenzone results in decreased expression of TIMP1 mRNA
[oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of TIMP1 mRNA; [oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of TIMP1 protein

NCBI chr X:20,736,524...20,740,972
Ensembl chr X:20,736,405...20,740,974

G

tight junction protein 1

decreases expression

EXP

oxybenzone results in decreased expression of TJP1 mRNA; oxybenzone results in decreased expression of TJP1 protein

NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529

G

T cell leukemia, homeobox 3

decreases expression

EXP

oxybenzone results in decreased expression of TLX3 mRNA

NCBI chr11:33,150,748...33,158,588
Ensembl chr11:33,150,752...33,153,589

G

transmembrane protein 100

decreases expression

EXP

oxybenzone results in decreased expression of TMEM100 mRNA

NCBI chr11:89,921,174...89,927,334
Ensembl chr11:89,921,174...89,927,334

G

transmembrane protease, serine 4

increases expression

ISO

oxybenzone results in increased expression of TMPRSS4 mRNA

NCBI chr 9:45,084,024...45,115,417
Ensembl chr 9:45,084,024...45,115,390

G

tumor necrosis factor (ligand) superfamily, member 11

decreases expression

EXP

oxybenzone results in decreased expression of TNFSF11 mRNA

NCBI chr14:78,514,886...78,545,483
Ensembl chr14:78,514,885...78,545,483

G

topoisomerase (DNA) II binding protein 1

increases expression

ISO

oxybenzone results in increased expression of TOPBP1 mRNA

NCBI chr 9:103,182,351...103,227,627
Ensembl chr 9:103,182,414...103,227,627

G

translocated promoter region, nuclear basket protein

increases expression

ISO

oxybenzone results in increased expression of TPR mRNA

NCBI chr 1:150,268,544...150,325,686
Ensembl chr 1:150,268,589...150,325,686

G

transformation related protein 53

decreases expression

ISO

oxybenzone results in decreased expression of TP53 mRNA

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

G

transformation related protein 53 binding protein 1

increases expression

ISO

oxybenzone results in increased expression of TP53BP1 protein

NCBI chr 2:121,025,316...121,126,830
Ensembl chr 2:121,023,762...121,101,888

G

transient receptor potential cation channel, subfamily V, member 4

decreases expression

EXP

oxybenzone results in decreased expression of TRPV4 mRNA

NCBI chr 5:114,760,213...114,796,497
Ensembl chr 5:114,760,213...114,796,482

G

translocator protein

decreases expression

ISO

oxybenzone results in decreased expression of TSPO mRNA

NCBI chr15:83,447,774...83,458,404
Ensembl chr15:83,447,793...83,458,404

G

twist basic helix-loop-helix transcription factor 1

multiple interactions

EXP

[oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of TWIST1 mRNA; [oxybenzone co-treated with Dietary Fats analog] results in decreased expression of TWIST1 mRNA

NCBI chr12:34,007,670...34,009,830
Ensembl chr12:34,007,670...34,009,828

G

UDP glucuronosyltransferase 1 family, polypeptide A6A

decreases expression

ISO

oxybenzone results in decreased expression of UGT1A6 mRNA

NCBI chr 1:88,062,531...88,147,724
Ensembl chr 1:88,062,531...88,146,719

G

UDP glucuronosyltransferase 2 family, polypeptide A3

decreases expression

ISO

oxybenzone results in decreased expression of UGT2A3 mRNA

NCBI chr 5:87,472,694...87,485,054
Ensembl chr 5:87,472,831...87,485,054

G

uroplakin 1B

decreases expression

ISO

oxybenzone results in decreased expression of UPK1B mRNA

NCBI chr16:38,593,544...38,620,565
Ensembl chr16:38,593,546...38,620,690

G

ubiquinol-cytochrome c reductase, complex III subunit XI

affects expression

ISO

oxybenzone affects the expression of UQCR11 mRNA

NCBI chr10:80,238,831...80,242,655
Ensembl chr10:80,238,831...80,242,664

G

ubiquinol-cytochrome c reductase core protein 1

increases expression

ISO

oxybenzone results in increased expression of UQCRC1 mRNA

NCBI chr 9:108,765,716...108,778,709
Ensembl chr 9:108,765,701...108,778,691

G

ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1

decreases expression

ISO

oxybenzone results in decreased expression of UQCRFS1 mRNA

NCBI chr13:30,724,295...30,729,299
Ensembl chr13:30,724,291...30,729,345

G

ubiquinol-cytochrome c reductase, complex III subunit VII

increases expression

ISO

oxybenzone results in increased expression of UQCRQ mRNA

NCBI chr11:53,318,749...53,321,658
Ensembl chr11:53,318,749...53,321,658

G

voltage-dependent anion channel 1

decreases expression

ISO

oxybenzone results in decreased expression of VDAC1 mRNA

NCBI chr11:52,251,905...52,280,224
Ensembl chr11:52,251,687...52,280,224

G

vascular endothelial growth factor A

multiple interactions
decreases expression

EXP

[oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of VEGFA mRNA
oxybenzone results in decreased expression of VEGFA mRNA

PMID:38387520 PMID:39343157

NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295

G

whey acidic protein

decreases expression

EXP

oxybenzone results in decreased expression of WAP mRNA; oxybenzone results in decreased expression of WAP protein

NCBI chr11:6,585,483...6,588,654
Ensembl chr11:6,585,482...6,588,637

G

WAP four-disulfide core domain 21

decreases expression

ISO

oxybenzone results in decreased expression of WFDC21 mRNA

NCBI chr11:83,637,766...83,643,472
Ensembl chr11:83,637,766...83,643,468

G

wingless-type MMTV integration site family, member 4

decreases expression

EXP

oxybenzone results in decreased expression of WNT4 mRNA

NCBI chr 4:137,004,946...137,026,812
Ensembl chr 4:137,004,800...137,027,037

G

wingless-type MMTV integration site family, member 5A

decreases expression

ISO

oxybenzone results in decreased expression of WNT5A mRNA

NCBI chr14:28,224,962...28,249,405
Ensembl chr14:28,226,707...28,249,405

G

Werner syndrome RecQ like helicase

increases expression

ISO

oxybenzone results in increased expression of WRN mRNA

NCBI chr 8:33,724,400...33,875,591
Ensembl chr 8:33,724,412...33,875,555

G

X-box binding protein 1

decreases expression

EXP

oxybenzone results in decreased expression of XBP1 mRNA

NCBI chr11:5,470,641...5,475,993
Ensembl chr11:5,470,659...5,475,893

G

zinc finger E-box binding homeobox 1

increases expression

ISO

oxybenzone results in increased expression of ZEB1 mRNA

NCBI chr18:5,591,330...5,775,468
Ensembl chr18:5,591,860...5,775,467

G

zinc finger protein 420

increases expression

ISO

oxybenzone results in increased expression of ZNF420 mRNA

NCBI chr 7:29,559,392...29,576,727
Ensembl chr 7:29,559,404...29,576,717

phenyl salicylate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

estrogen receptor 1 (alpha)

increases activity
multiple interactions

ISO

phenyl salicylate results in increased activity of ESR1 protein
phenyl salicylate binds to and results in increased activity of ESR1 protein

PMID:22197706 PMID:24004914

NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

amyloid beta precursor protein

increases uptake

EXP

Thiourea results in increased uptake of APP protein modified form

NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654

G

aquaporin 1

decreases expression

ISO

Thiourea results in decreased expression of AQP1 mRNA

NCBI chr 6:55,313,284...55,325,540
Ensembl chr 6:55,313,417...55,325,540

G

aquaporin 3

increases expression

ISO

Thiourea results in increased expression of AQP3 mRNA

NCBI chr 4:41,092,724...41,098,183
Ensembl chr 4:41,092,722...41,098,183

G

aquaporin 4

decreases expression

ISO

Thiourea results in decreased expression of AQP4 mRNA

NCBI chr18:15,522,451...15,544,039
Ensembl chr18:15,522,553...15,544,039

G

aquaporin 5

decreases expression

ISO

Thiourea results in decreased expression of AQP5 mRNA

NCBI chr15:99,488,909...99,492,710
Ensembl chr15:99,488,663...99,492,710

G

aquaporin 9

increases uptake

ISO

AQP9 protein results in increased uptake of Thiourea

NCBI chr 9:71,017,941...71,075,170
Ensembl chr 9:71,017,941...71,075,964

G

BCL2-associated X protein

multiple interactions

ISO

Thiourea inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of BAX protein]

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

carbonic anhydrase 1

decreases activity

ISO

Thiourea analog results in decreased activity of CA1 protein

NCBI chr 3:14,831,274...14,873,425
Ensembl chr 3:14,831,276...14,873,428

G

carbonic anhydrase 2

decreases activity

ISO

Thiourea analog results in decreased activity of CA2 protein

NCBI chr 3:14,951,329...14,965,830
Ensembl chr 3:14,951,333...14,965,830

G

caspase 3

multiple interactions

ISO

Thiourea analog inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]
Thiourea inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased activity of CASP3 protein]

PMID:14599462 PMID:29803612

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

cystic fibrosis transmembrane conductance regulator

decreases expression

ISO

Thiourea results in decreased expression of CFTR mRNA

NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767

G

C-X-C motif chemokine ligand 15

multiple interactions

ISO

Thiourea inhibits the reaction [cadmium acetate results in increased secretion of CXCL8 protein]; Thiourea inhibits the reaction [Particulate Matter results in increased expression of CXCL8 mRNA]; Thiourea inhibits the reaction [sodium arsenite results in increased secretion of CXCL8 protein]; Thiourea inhibits the reaction [Vehicle Emissions results in increased expression of CXCL8 mRNA]; Thiourea inhibits the reaction [zinc chloride results in increased secretion of CXCL8 protein]

PMID:26160521 PMID:27427241

NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926

G

flavin containing monooxygenase 2

increases metabolic processing

ISO

FMO2 protein results in increased metabolism of Thiourea

NCBI chr 1:162,701,886...162,726,327
Ensembl chr 1:162,701,886...162,726,295

G

flavin containing monooxygenase 3

multiple interactions
increases response to substance

ISO

Buthionine Sulfoximine inhibits the reaction [FMO3 protein results in increased susceptibility to Thiourea]

NCBI chr 1:162,781,368...162,812,097
Ensembl chr 1:162,781,369...162,812,097

G

FBJ osteosarcoma oncogene

multiple interactions

EXP

Thiourea inhibits the reaction [tert-Butylhydroperoxide results in increased expression of FOS mRNA]

NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047

G

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

multiple interactions

ISO

Thiourea inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR mRNA]; Thiourea inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR protein]

NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444

G

interferon gamma

multiple interactions

EXP

Thiourea analog inhibits the reaction [IFNG protein promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of SPP1 mRNA]]

NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797

G

interleukin 6

multiple interactions

ISO

Thiourea inhibits the reaction [cadmium acetate results in increased secretion of IL6 protein]; Thiourea inhibits the reaction [Particulate Matter results in increased expression of IL6 mRNA]; Thiourea inhibits the reaction [sodium arsenite results in increased secretion of IL6 protein]; Thiourea inhibits the reaction [Vehicle Emissions results in increased expression of IL6 mRNA]; Thiourea inhibits the reaction [zinc chloride results in increased secretion of IL6 protein]

PMID:26160521 PMID:27427241

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

jun proto-oncogene

multiple interactions

EXP

Thiourea inhibits the reaction [tert-Butylhydroperoxide results in increased expression of JUN mRNA]

NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459

G

nitric oxide synthase 2, inducible

decreases expression
multiple interactions

EXP

Thiourea analog results in decreased expression of NOS2 mRNA; Thiourea analog results in decreased expression of NOS2 protein; Thiourea results in decreased expression of NOS2 protein
[Thiourea analog results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; Thiourea results in decreased susceptibility to [Lipopolysaccharides results in increased expression of NOS2 protein]

PMID:17467989 PMID:20637185

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

prostaglandin-endoperoxide synthase 2

decreases expression
multiple interactions

EXP

Thiourea results in decreased expression of PTGS2 protein
Thiourea results in decreased susceptibility to [Lipopolysaccharides results in increased expression of PTGS2 protein]

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

sodium channel, nonvoltage-gated 1 alpha

decreases expression

ISO

Thiourea results in decreased expression of SCNN1A mRNA

NCBI chr 6:125,286,657...125,321,906
Ensembl chr 6:125,297,622...125,321,906

G

sodium channel, nonvoltage-gated 1 beta

decreases expression

ISO

Thiourea results in decreased expression of SCNN1B mRNA

NCBI chr 7:121,464,261...121,517,951
Ensembl chr 7:121,464,261...121,517,737

G

sodium channel, nonvoltage-gated 1 gamma

decreases expression

ISO

Thiourea results in decreased expression of SCNN1G mRNA

NCBI chr 7:121,333,643...121,367,705
Ensembl chr 7:121,333,702...121,367,698

G

solute carrier family 14 (urea transporter), member 1

multiple interactions

EXP

Thiourea inhibits the reaction [SLC14A1 protein affects the transport of Urea]

NCBI chr18:78,143,306...78,185,334
Ensembl chr18:78,143,306...78,185,334

G

solute carrier family 14 (urea transporter), member 2

multiple interactions

ISO

Thiourea analog inhibits the reaction [SLC14A2 protein results in increased transport of Urea]

NCBI chr18:78,189,359...78,640,165
Ensembl chr18:78,189,363...78,640,157

G

secreted phosphoprotein 1

multiple interactions

EXP

Thiourea analog inhibits the reaction [IFNG protein promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of SPP1 mRNA]]

NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916

G

transformation related protein 53

multiple interactions

ISO

Thiourea inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of TP53 protein]

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

trans-urocanic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

filaggrin

decreases abundance

ISO

FLG mutant form results in decreased abundance of Urocanic Acid

NCBI chr 3:93,180,853...93,200,996
Ensembl chr 3:93,180,830...93,200,993

G

interferon gamma

multiple interactions

EXP

IFNG protein affects the susceptibility to [Permethrin co-treated with Urocanic Acid]

NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797

G

tumor necrosis factor

affects response to substance

EXP

TNF protein affects the susceptibility to Urocanic Acid

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

filaggrin

decreases abundance

ISO

FLG mutant form results in decreased abundance of Urocanic Acid

NCBI chr 3:93,180,853...93,200,996
Ensembl chr 3:93,180,830...93,200,993

G

interferon gamma

multiple interactions

EXP

IFNG protein affects the susceptibility to [Permethrin co-treated with Urocanic Acid]

NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797

G

tumor necrosis factor

affects response to substance

EXP

TNF protein affects the susceptibility to Urocanic Acid

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	22491
role	22476
chemical role	21315
photochemical role	404
chromophore +	53
lumiphore	0
photobiochemical role +	0
ultraviolet filter +	370

paths to the root