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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:photochemical role
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Accession:CHEBI:52215 term browser browse the term
Definition:A chemical role played by the molecular entity or part thereof in a photochemical process.
Synonyms:related_synonym: photochemical roles


show annotations for term's descendants           Sort by:
3,6-diaminoacridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Proflavine inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:30818834 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO Proflavine results in increased activity of ESR1 protein CTD PMID:30818834 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions ISO Proflavine inhibits the reaction [XCT790 results in decreased activity of ESRRA protein] CTD PMID:30818834 NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Proflavine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases activity ISO Proflavine results in increased activity of NFE2L2 protein CTD PMID:30818834 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Proflavine inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; Proflavine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 PMID:30818834 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Proflavine inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of NR1I3 protein] CTD PMID:30818834 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO Proflavine inhibits the reaction [Promegestone results in increased activity of PGR protein] CTD PMID:30818834 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Proflavine inhibits the reaction [Rosiglitazone results in increased activity of PPARG protein] CTD PMID:30818834 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Tp53 tumor protein p53 increases activity
affects activity		 ISO Proflavine results in increased activity of TP53 protein
Proflavine affects the activity of TP53 protein		 CTD PMID:30818834 PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
alizarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
multiple interactions		 ISO alizarin results in decreased activity of CYP1A1 protein
alizarin affects the reaction [Benzo(a)pyrene affects the activity of CYP1A1 protein]		 CTD PMID:12379470 PMID:37515497 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO alizarin results in decreased activity of CYP1A2 protein CTD PMID:12379470 PMID:33438235 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO alizarin results in decreased activity of CYP1B1 protein CTD PMID:12379470 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO alizarin results in decreased activity of CYP2E1 protein CTD PMID:12379470 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO alizarin binds to and results in increased activity of ESR1 protein CTD PMID:20707409 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO alizarin inhibits the reaction [Benzo(a)pyrene results in increased expression of H2AX protein] CTD PMID:37515497 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO alizarin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein] CTD PMID:33421718 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO alizarin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK3 protein] CTD PMID:33421718 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO alizarin inhibits the reaction [Benzo(a)pyrene results in increased expression of MUC5AC mRNA]; alizarin inhibits the reaction [Benzo(a)pyrene results in increased expression of MUC5AC protein] CTD PMID:33421718 NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475 		JBrowse link
G Nat1 N-acetyltransferase 1 decreases activity ISO alizarin results in decreased activity of NAT1 protein CTD PMID:34783865 NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of alizarin CTD PMID:14557274 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of alizarin CTD PMID:14557274 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of alizarin CTD PMID:7574722 NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589 		JBrowse link
esculetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGTR1A mRNA]; esculetin inhibits the reaction [Dietary Fats results in increased expression of AGTR1A mRNA] CTD PMID:28946194 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions EXP esculetin inhibits the reaction [Dietary Fats results in increased expression of AGTR2 mRNA]; esculetin promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGTR2 mRNA] CTD PMID:28946194 NCBI chr  X:112,119,876...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO esculetin results in increased phosphorylation of AKT1 protein CTD PMID:24995577 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase decreases expression ISO esculetin results in decreased expression of ALOX15 protein CTD PMID:30171828 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO esculetin results in increased expression of BAK1 protein CTD PMID:26388407 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
affects expression
affects localization		 ISO [esculetin co-treated with Paclitaxel] results in increased expression of BAX protein
esculetin results in increased expression of BAX protein
esculetin affects the expression of BAX protein
esculetin affects the localization of BAX protein		 CTD PMID:16051289 PMID:19786087 PMID:24995577 PMID:26388407 PMID:31313495 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression
decreases expression		 ISO esculetin affects the expression of BCL2 protein
esculetin results in decreased expression of BCL2 protein		 CTD PMID:24995577 PMID:26388407 PMID:31313495 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression		 ISO [esculetin co-treated with Paclitaxel] results in decreased expression of BCL2L1 protein
esculetin results in decreased expression of BCL2L1 protein		 CTD PMID:16051289 PMID:26388407 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [arsenic trioxide co-treated with esculetin] results in increased cleavage of BID protein CTD PMID:19428345 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Bmp6 bone morphogenetic protein 6 multiple interactions EXP esculetin inhibits the reaction [Streptozocin results in decreased expression of BMP6 mRNA] CTD PMID:21450970 NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity		 ISO [esculetin co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP3 protein
esculetin results in increased cleavage of CASP3 protein
esculetin results in increased activity of CASP3 protein		 CTD PMID:16051289 PMID:24995577 PMID:26388407 PMID:31313495 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases cleavage ISO esculetin results in increased cleavage of CASP7 protein CTD PMID:31313495 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO [esculetin co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:16051289 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity
increases cleavage		 ISO esculetin results in increased activity of CASP9 protein
esculetin results in increased cleavage of CASP9 protein		 CTD PMID:24995577 PMID:26388407 PMID:31313495 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions EXP esculetin inhibits the reaction [Doxorubicin results in decreased expression of CAT mRNA] CTD PMID:38567888 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of CCL2 protein] CTD PMID:27769711 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccnd1 cyclin D1 decreases expression EXP
ISO		 esculetin results in decreased expression of CCND1 protein CTD PMID:21600278 PMID:31313495 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression
multiple interactions		 EXP esculetin results in decreased expression of CDK2 protein
esculetin promotes the reaction [CDKN1A protein binds to CDK2 protein]; SB 203580 inhibits the reaction [esculetin results in decreased expression of CDK2 protein]		 CTD PMID:21600278 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression
multiple interactions		 EXP esculetin results in decreased expression of CDK4 protein
esculetin promotes the reaction [CDKN1A protein binds to CDK4 protein]; SB 203580 inhibits the reaction [esculetin results in decreased expression of CDK4 protein]		 CTD PMID:21600278 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression		 EXP
ISO		 esculetin promotes the reaction [CDKN1A protein binds to CDK2 protein]; esculetin promotes the reaction [CDKN1A protein binds to CDK4 protein]; SB 203580 inhibits the reaction [esculetin results in increased expression of CDKN1A protein] CTD PMID:21600278 PMID:31313495 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO esculetin results in increased expression of CDKN1B protein CTD PMID:31313495 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Comt catechol-O-methyltransferase increases methylation ISO COMT protein results in increased methylation of esculetin CTD PMID:11160877 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [arsenic trioxide co-treated with esculetin] affects the localization of CYCS protein; [esculetin co-treated with Paclitaxel] affects the localization of CYCS protein CTD PMID:16051289 PMID:19428345 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO [esculetin co-treated with Paclitaxel] results in increased expression of FAS protein CTD PMID:16051289 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand multiple interactions ISO [esculetin co-treated with Paclitaxel] results in increased expression of FASLG protein CTD PMID:16051289 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO esculetin promotes the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of FASN mRNA] CTD PMID:27769711 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP esculetin inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]; esculetin inhibits the reaction [Streptozocin results in increased expression of FN1 protein] CTD PMID:21450970 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions ISO esculetin promotes the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased activity of G6PC1 protein] CTD PMID:27769711 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL6 mRNA]; esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL6 protein] CTD PMID:27769711 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO
EXP		 [esculetin co-treated with Paclitaxel] results in decreased expression of MAPK1 protein; esculetin results in decreased phosphorylation of and results in decreased activity of MAPK1 protein
esculetin results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [esculetin results in increased phosphorylation of MAPK1 protein]; SB 203580 inhibits the reaction [esculetin results in increased phosphorylation of MAPK1 protein]		 CTD PMID:16051289 PMID:21600278 PMID:24995577 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO [esculetin co-treated with Paclitaxel] results in decreased expression of MAPK14 protein; esculetin results in decreased phosphorylation of and results in decreased activity of MAPK14 protein CTD PMID:16051289 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO
EXP		 [esculetin co-treated with Paclitaxel] results in decreased expression of MAPK3 protein; esculetin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein
esculetin results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [esculetin results in increased phosphorylation of MAPK3 protein]; SB 203580 inhibits the reaction [esculetin results in increased phosphorylation of MAPK3 protein]		 CTD PMID:16051289 PMID:21600278 PMID:24995577 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
increases expression		 ISO [esculetin co-treated with Paclitaxel] results in increased expression of MAPK8 protein
esculetin results in increased phosphorylation of MAPK8 protein
esculetin results in increased expression of MAPK8 protein		 CTD PMID:16051289 PMID:19786087 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases expression		 ISO [esculetin co-treated with Paclitaxel] results in increased expression of MAPK9 protein
esculetin results in increased expression of MAPK9 protein		 CTD PMID:16051289 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions EXP esculetin inhibits the reaction [Streptozocin results in increased expression of MMP13 mRNA] CTD PMID:21450970 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of MYD88 mRNA] CTD PMID:27769711 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases localization
affects localization		 ISO esculetin results in increased localization of NFE2L2 protein
esculetin affects the localization of NFE2L2 protein		 CTD PMID:20933534 PMID:30171828 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 affects localization ISO esculetin affects the localization of NFKB1 protein CTD PMID:30171828 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO esculetin promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:16212885 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NOS3 mRNA]; esculetin inhibits the reaction [Dietary Fats results in decreased expression of NOS3 mRNA] CTD PMID:28946194 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression		 ISO esculetin results in increased expression of and results in increased activity of NQO1 protein
esculetin results in increased expression of NQO1 mRNA		 CTD PMID:20933534 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO esculetin results in increased cleavage of PARP1 protein CTD PMID:26388407 PMID:31313495 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP
ISO		 esculetin inhibits the reaction [Streptozocin results in decreased expression of PPARG protein]; esculetin inhibits the reaction [Streptozocin results in increased expression of PPARG protein]
esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PPARG mRNA]		 CTD PMID:21450970 PMID:27769711 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization ISO esculetin affects the localization of RELA protein CTD PMID:30171828 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sod1 superoxide dismutase 1 affects expression ISO esculetin affects the expression of SOD1 protein CTD PMID:30171828 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sp1 Sp1 transcription factor decreases expression ISO esculetin results in decreased expression of SP1 protein CTD PMID:31313495 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP esculetin inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein] CTD PMID:21450970 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TLR4 mRNA] CTD PMID:27769711 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TNF mRNA]; esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TNF protein] CTD PMID:27769711 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO esculetin results in increased expression of TNFRSF10A protein CTD PMID:19786087 NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467 		JBrowse link
G Tp53 tumor protein p53 increases degradation
increases expression		 ISO esculetin results in increased degradation of TP53 protein
esculetin results in increased expression of TP53 protein		 CTD PMID:14634213 PMID:31313495 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of esculetin CTD PMID:7574722 NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589 		JBrowse link
G Usp16 ubiquitin specific peptidase 16 multiple interactions EXP esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of USP16 mRNA]; esculetin inhibits the reaction [Dietary Fats results in increased expression of USP16 mRNA] CTD PMID:28946194 NCBI chr11:26,681,359...26,711,313
Ensembl chr11:26,681,414...26,710,539 		JBrowse link
G Usp22 ubiquitin specific peptidase 22 multiple interactions EXP esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of USP22 mRNA]; esculetin inhibits the reaction [Dietary Fats results in increased expression of USP22 mRNA] CTD PMID:28946194 NCBI chr10:45,828,619...45,855,468
Ensembl chr10:45,828,622...45,855,497 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of VCAM1 mRNA]; esculetin inhibits the reaction [Dietary Fats results in increased expression of VCAM1 mRNA] CTD PMID:28946194 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
N-phenylthiourea term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Car1 carbonic anhydrase 1 decreases activity ISO Phenylthiourea analog results in decreased activity of CA1 protein CTD PMID:30291660 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208 		JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Phenylthiourea analog results in decreased activity of CA2 protein CTD PMID:30291660 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Casp9 caspase 9 increases expression ISO Phenylthiourea results in increased expression of CASP9 protein CTD PMID:16447258 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 increases response to substance ISO FMO3 protein results in increased susceptibility to Phenylthiourea CTD PMID:12093470 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Phenylthiourea results in decreased expression of FOS protein CTD PMID:18003792 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Phenylthiourea results in increased phosphorylation of MAPK1 protein CTD PMID:26051519 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Phenylthiourea results in increased phosphorylation of MAPK3 protein CTD PMID:26051519 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mitf melanocyte inducing transcription factor increases expression ISO Phenylthiourea results in increased expression of MITF protein CTD PMID:26051519 NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO Phenylthiourea results in increased expression of PPARA protein CTD PMID:16447258 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression ISO Phenylthiourea results in increased expression of RELA protein CTD PMID:16447258 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tas2r138 taste receptor, type 2, member 138 affects response to substance
affects activity
increases activity
multiple interactions		 ISO TAS2R38 gene polymorphism affects the susceptibility to Phenylthiourea
Phenylthiourea affects the activity of TAS2R38
Phenylthiourea results in increased activity of TAS2R38 protein
4-((diethylamino)sulfonyl)benzoic acid inhibits the reaction [Phenylthiourea results in increased activity of TAS2R38 protein]; Probenecid inhibits the reaction [Phenylthiourea results in increased activity of TAS2R38 protein]		 CTD PMID:17684414 PMID:21629661 PMID:22384968 NCBI chr 4:69,428,344...69,429,339
Ensembl chr 4:69,428,344...69,429,339 		JBrowse link
oxybenzone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acad10 acyl-CoA dehydrogenase family, member 10 increases expression EXP oxybenzone results in increased expression of ACAD10 mRNA CTD PMID:30316929 NCBI chr12:34,901,211...34,943,973
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Acad9 acyl-CoA dehydrogenase family, member 9 increases expression EXP oxybenzone results in increased expression of ACAD9 mRNA CTD PMID:30316929 NCBI chr 2:118,943,170...118,966,150
Ensembl chr 2:118,943,174...118,966,547 		JBrowse link
G Acbd3 acyl-CoA binding domain containing 3 decreases expression EXP oxybenzone results in decreased expression of ACBD3 mRNA CTD PMID:30316929 NCBI chr13:92,455,813...92,484,556
Ensembl chr13:92,455,655...92,483,380 		JBrowse link
G Aco2 aconitase 2 affects expression EXP oxybenzone affects the expression of ACO2 mRNA CTD PMID:30316929 NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261 		JBrowse link
G Acot2 acyl-CoA thioesterase 2 increases expression EXP oxybenzone results in increased expression of ACOT2 mRNA CTD PMID:30316929 NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245 		JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression EXP oxybenzone results in increased expression of ACOX1 mRNA CTD PMID:30316929 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 decreases expression EXP oxybenzone results in decreased expression of ACSL5 mRNA CTD PMID:30316929 NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607 		JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 increases expression EXP oxybenzone results in increased expression of ACSS2 mRNA CTD PMID:30316929 NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ mRNA]; oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ protein]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ mRNA]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ protein] CTD PMID:32407875 PMID:34864131 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Adprhl1 ADP-ribosylhydrolase like 1 affects expression EXP oxybenzone affects the expression of ADPRHL1 mRNA CTD PMID:30316929 NCBI chr16:76,283,186...76,315,075
Ensembl chr16:76,283,103...76,354,440 		JBrowse link
G Ahr aryl hydrocarbon receptor decreases expression
increases expression		 EXP oxybenzone results in decreased expression of AHR mRNA
oxybenzone results in increased expression of AHR protein		 CTD PMID:15458797 PMID:30099065 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Aif1 allograft inflammatory factor 1 increases expression EXP oxybenzone results in increased expression of AIF1 mRNA; oxybenzone results in increased expression of AIF1 protein CTD PMID:31368502 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 increases expression ISO oxybenzone results in increased expression of AKT3 mRNA CTD PMID:36581016 NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708 		JBrowse link
G Angpt1 angiopoietin 1 multiple interactions ISO [oxybenzone co-treated with Dietary Fats analog] results in decreased expression of ANGPT1 mRNA CTD PMID:38387520 NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067 		JBrowse link
G Angpt2 angiopoietin 2 multiple interactions ISO [oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of ANGPT2 mRNA CTD PMID:38387520 NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804 		JBrowse link
G Angpt4 angiopoietin 4 multiple interactions ISO [oxybenzone co-treated with Dietary Fats analog] results in decreased expression of ANGPT4 mRNA CTD PMID:38387520 NCBI chr 3:140,420,389...140,454,213
Ensembl chr 3:140,420,389...140,453,583 		JBrowse link
G Angptl4 angiopoietin-like 4 multiple interactions ISO [oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of ANGPTL4 mRNA CTD PMID:38387520 NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519 		JBrowse link
G Apc APC regulator of WNT signaling pathway increases expression ISO oxybenzone results in increased expression of APC mRNA CTD PMID:36581016 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696 		JBrowse link
G Apoc3 apolipoprotein C3 increases expression EXP oxybenzone results in increased expression of APOC3 mRNA CTD PMID:30316929 NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583 		JBrowse link
G Apol2 apolipoprotein L2 increases expression EXP oxybenzone results in increased expression of APOL2 mRNA CTD PMID:30316929 NCBI chr 7:109,331,367...109,338,632
Ensembl chr 7:109,331,392...109,338,558 		JBrowse link
G Aqp1 aquaporin 1 decreases expression EXP oxybenzone results in decreased expression of AQP1 mRNA CTD PMID:30316929 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690 		JBrowse link
G Ar androgen receptor multiple interactions
affects localization		 ISO
EXP		 oxybenzone binds to and results in decreased activity of AR protein; oxybenzone inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; oxybenzone inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]
oxybenzone affects the localization of AR protein		 CTD PMID:12730620 PMID:15537743 PMID:15950433 PMID:30099065 PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Areg amphiregulin increases expression
decreases expression		 ISO oxybenzone results in increased expression of AREG mRNA
oxybenzone results in decreased expression of AREG mRNA		 CTD PMID:31939680 PMID:38382712 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535 		JBrowse link
G Atf2 activating transcription factor 2 increases expression ISO oxybenzone results in increased expression of ATF2 mRNA CTD PMID:36581016 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236 		JBrowse link
G Atg2b autophagy related 2B increases expression ISO oxybenzone results in increased expression of ATG2B mRNA CTD PMID:36581016 NCBI chr 6:124,522,283...124,592,412
Ensembl chr 6:124,525,523...124,592,015 		JBrowse link
G Atm ATM serine/threonine kinase increases expression ISO oxybenzone results in increased expression of ATM mRNA CTD PMID:36581016 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha increases expression EXP oxybenzone results in increased expression of ATP5F1A mRNA CTD PMID:30316929 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794 		JBrowse link
G Atp5f1b ATP synthase F1 subunit beta increases expression EXP oxybenzone results in increased expression of ATP5F1B mRNA CTD PMID:30316929 NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273 		JBrowse link
G Atp5f1c ATP synthase F1 subunit gamma increases expression EXP oxybenzone results in increased expression of ATP5F1C mRNA CTD PMID:30316929 NCBI chr17:68,423,927...68,446,169
Ensembl chr17:68,423,909...68,608,367 		JBrowse link
G Atp5mc2 ATP synthase membrane subunit c locus 2 decreases expression EXP oxybenzone results in decreased expression of ATP5MC2 mRNA CTD PMID:30316929 NCBI chr 7:133,791,341...133,799,713
Ensembl chr 7:133,791,342...133,799,733 		JBrowse link
G Atr ATR serine/threonine kinase increases expression ISO oxybenzone results in increased expression of ATR mRNA CTD PMID:36581016 NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression EXP oxybenzone results in increased expression of BAD mRNA CTD PMID:30316929 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression EXP oxybenzone results in increased expression of BAK1 mRNA; oxybenzone results in increased expression of BAK1 protein CTD PMID:30099065 PMID:30316929 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP oxybenzone results in increased expression of BAX mRNA; oxybenzone results in increased expression of BAX protein CTD PMID:30099065 PMID:30316929 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression EXP oxybenzone results in decreased expression of BCL2L1 mRNA CTD PMID:30316929 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bcs1l BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone increases expression EXP oxybenzone results in increased expression of BCS1L mRNA CTD PMID:30316929 NCBI chr 9:76,164,925...76,168,940
Ensembl chr 9:76,164,932...76,168,938 		JBrowse link
G Blm BLM RecQ like helicase increases expression ISO oxybenzone results in increased expression of BLM mRNA CTD PMID:36581016 NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312 		JBrowse link
G Brca1 BRCA1, DNA repair associated increases expression ISO oxybenzone results in increased expression of BRCA1 mRNA CTD PMID:36581016 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 increases expression ISO oxybenzone results in increased expression of CACNA2D1 mRNA CTD PMID:36581016 NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969 		JBrowse link
G Casp1 caspase 1 decreases expression EXP oxybenzone results in decreased expression of CASP1 mRNA CTD PMID:30316929 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp2 caspase 2 increases expression EXP oxybenzone results in increased expression of CASP2 mRNA CTD PMID:30316929 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 EXP oxybenzone results in increased activity of CASP3 protein
oxybenzone results in increased expression of and results in increased activity of CASP3 protein		 CTD PMID:30099065 PMID:31368502 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp4 caspase 4 decreases expression EXP oxybenzone results in decreased expression of CASP4 mRNA CTD PMID:30316929 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Casp9 caspase 9 increases activity
increases expression		 EXP oxybenzone results in increased activity of CASP9 protein
oxybenzone results in increased expression of CASP9 mRNA		 CTD PMID:30099065 PMID:30316929 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccl21 C-C motif chemokine ligand 21 decreases expression EXP oxybenzone results in decreased expression of CCL21 mRNA CTD PMID:30316929 NCBI chr 5:56,980,557...56,981,661
Ensembl chr 5:56,980,558...56,981,686 		JBrowse link
G Ccne2 cyclin E2 increases expression ISO oxybenzone results in increased expression of CCNE2 mRNA CTD PMID:36581016 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex increases expression ISO oxybenzone results in increased expression of CHUK mRNA CTD PMID:36581016 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Cited4 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 increases expression EXP oxybenzone results in increased expression of CITED4 mRNA CTD PMID:30316929 NCBI chr 5:134,246,936...134,247,827
Ensembl chr 5:134,246,682...134,248,135 		JBrowse link
G Cox15 cytochrome c oxidase assembly homolog COX15 increases expression EXP oxybenzone results in increased expression of COX15 mRNA CTD PMID:30316929 NCBI chr 1:242,605,588...242,622,279
Ensembl chr 1:242,605,588...242,622,261 		JBrowse link
G Cox16 cytochrome c oxidase assembly factor COX16 decreases expression EXP oxybenzone results in decreased expression of COX16 mRNA CTD PMID:30316929 NCBI chr 6:101,162,231...101,181,277
Ensembl chr 6:101,019,680...101,181,246 		JBrowse link
G Cox17 cytochrome c oxidase copper chaperone COX17 increases expression EXP oxybenzone results in increased expression of COX17 mRNA CTD PMID:30316929 NCBI chr11:62,400,733...62,406,507 JBrowse link
G Cox18 cytochrome c oxidase assembly factor COX18 increases expression EXP oxybenzone results in increased expression of COX18 mRNA CTD PMID:30316929 NCBI chr14:17,864,581...17,877,483
Ensembl chr14:17,865,857...17,877,480 		JBrowse link
G Cox5a cytochrome c oxidase subunit 5A increases expression EXP oxybenzone results in increased expression of COX5A mRNA CTD PMID:30316929 NCBI chr 8:57,922,374...57,933,781
Ensembl chr 8:57,922,290...57,933,781 		JBrowse link
G Cox6b2 cytochrome c oxidase subunit 6B2 decreases expression EXP oxybenzone results in decreased expression of COX6B2 mRNA CTD PMID:30316929 NCBI chr 1:69,094,009...69,095,312 JBrowse link
G Cox7a2 cytochrome c oxidase subunit 7A2 decreases expression EXP oxybenzone results in decreased expression of COX7A2 mRNA CTD PMID:30316929 NCBI chr 8:80,716,824...80,720,922
Ensembl chr14:51,301,168...51,301,633
Ensembl chr 8:51,301,168...51,301,633 		JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B increases expression EXP oxybenzone results in increased expression of CPT1B mRNA CTD PMID:30316929 NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404 		JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 increases expression EXP oxybenzone results in increased expression of CPT2 mRNA CTD PMID:30316929 NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095 		JBrowse link
G Cpxm2 carboxypeptidase X (M14 family), member 2 decreases expression EXP oxybenzone results in decreased expression of CPXM2 mRNA CTD PMID:30316929 NCBI chr 1:186,836,797...186,947,222
Ensembl chr 1:186,836,797...186,947,220 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression ISO oxybenzone results in increased expression of CREB1 mRNA CTD PMID:36581016 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Csn2 casein beta increases expression
decreases methylation		 ISO oxybenzone results in increased expression of CSN2 mRNA; oxybenzone results in increased expression of CSN2 protein
oxybenzone results in decreased methylation of CSN2 promoter		 CTD PMID:32946892 NCBI chr14:20,322,581...20,329,818
Ensembl chr14:20,322,581...20,329,817 		JBrowse link
G Cstl1 cystatin-like 1 decreases expression EXP oxybenzone results in decreased expression of CSTL1 mRNA CTD PMID:30316929 NCBI chr 3:136,199,914...136,204,912
Ensembl chr 3:136,199,914...136,204,912 		JBrowse link
G Cybrd1 cytochrome b reductase 1 increases expression EXP oxybenzone results in increased expression of CYBRD1 mRNA CTD PMID:30316929 NCBI chr 3:55,934,874...55,962,132
Ensembl chr 3:55,934,874...55,962,108 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression EXP oxybenzone results in increased expression of CYP19A1 mRNA CTD PMID:30599193 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 decreases expression EXP oxybenzone results in decreased expression of CYP24A1 mRNA CTD PMID:30316929 NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383 		JBrowse link
G Cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 increases expression EXP oxybenzone results in increased expression of CYP26C1 mRNA CTD PMID:30316929 NCBI chr 1:235,458,961...235,468,433
Ensembl chr 1:235,459,356...235,466,842 		JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 increases expression EXP oxybenzone results in increased expression of CYP27B1 mRNA CTD PMID:30316929 NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases expression EXP oxybenzone results in decreased expression of CYP2B3 mRNA CTD PMID:30316929 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2d3 cytochrome P450, family 2, subfamily d, polypeptide 3 increases expression EXP oxybenzone results in increased expression of CYP2D3 mRNA CTD PMID:30316929 NCBI chr 7:113,917,711...113,922,068
Ensembl chr 7:113,908,947...113,922,084 		JBrowse link
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 decreases expression EXP oxybenzone results in decreased expression of CYP4A3 mRNA CTD PMID:30316929 NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463 		JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 increases expression EXP oxybenzone results in increased expression of CYP4F18 mRNA CTD PMID:30316929 NCBI chr16:17,763,543...17,804,944
Ensembl chr16:17,707,317...17,804,940 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression EXP oxybenzone results in increased expression of CYP7A1 mRNA CTD PMID:30316929 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Dap death-associated protein decreases expression EXP oxybenzone results in decreased expression of DAP mRNA CTD PMID:30316929 NCBI chr 2:82,199,206...82,251,771
Ensembl chr 2:82,199,280...82,251,752 		JBrowse link
G Dapk3 death-associated protein kinase 3 increases expression EXP oxybenzone results in increased expression of DAPK3 mRNA CTD PMID:30316929 NCBI chr 7:8,524,182...8,532,552
Ensembl chr 7:8,524,183...8,532,558 		JBrowse link
G Daxx death-domain associated protein increases expression
increases methylation		 EXP
ISO		 oxybenzone results in increased expression of DAXX mRNA
oxybenzone results in increased methylation of DAXX gene		 CTD PMID:30316929 PMID:34523531 NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843 		JBrowse link
G Dedd death effector domain-containing increases expression EXP oxybenzone results in increased expression of DEDD mRNA CTD PMID:30316929 NCBI chr13:83,755,874...83,769,982
Ensembl chr13:83,756,108...83,769,332 		JBrowse link
G Dffa DNA fragmentation factor subunit alpha increases expression EXP oxybenzone results in increased expression of DFFA mRNA CTD PMID:30316929 NCBI chr 5:159,540,715...159,553,639
Ensembl chr 5:159,540,715...159,553,633 		JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) increases expression EXP oxybenzone results in increased expression of DHODH mRNA CTD PMID:30316929 NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654 		JBrowse link
G Dld dihydrolipoamide dehydrogenase increases expression ISO oxybenzone results in increased expression of DLD mRNA CTD PMID:36581016 NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795 		JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase increases expression EXP oxybenzone results in increased expression of DLST mRNA CTD PMID:30316929 NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296 		JBrowse link
G Dlx3 distal-less homeobox 3 affects expression EXP oxybenzone affects the expression of DLX3 mRNA CTD PMID:30316929 NCBI chr10:80,064,489...80,069,891
Ensembl chr10:80,064,489...80,069,872 		JBrowse link
G Dmtf1 cyclin D binding myb-like transcription factor 1 increases expression ISO oxybenzone results in increased expression of DMTF1 mRNA CTD PMID:36581016 NCBI chr 4:24,909,937...24,950,786
Ensembl chr 4:24,910,534...24,950,967 		JBrowse link
G Dnajc15 DnaJ heat shock protein family (Hsp40) member C15 decreases expression EXP oxybenzone results in decreased expression of DNAJC15 mRNA CTD PMID:30316929 NCBI chr15:53,182,060...53,249,675
Ensembl chr15:53,184,855...53,249,675 		JBrowse link
G Echs1 enoyl-CoA hydratase, short chain 1 increases expression EXP oxybenzone results in increased expression of ECHS1 mRNA CTD PMID:30316929 NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884 		JBrowse link
G Eif4e eukaryotic translation initiation factor 4E increases expression ISO oxybenzone results in increased expression of EIF4E mRNA CTD PMID:36581016 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression
increases expression
multiple interactions		 EXP
ISO		 oxybenzone results in decreased expression of ESR1 mRNA; oxybenzone results in decreased expression of ESR1 protein
oxybenzone results in increased expression of ESR1 mRNA
oxybenzone binds to and results in increased activity of ESR1 protein		 CTD PMID:15458797 PMID:16079615 PMID:30099065 PMID:32946892 PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects expression
decreases expression		 ISO
EXP		 oxybenzone binds to and results in increased activity of ESR2 protein
oxybenzone affects the expression of ESR2 protein
oxybenzone results in decreased expression of ESR2 mRNA		 CTD PMID:16079615 PMID:30099065 PMID:33049310 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Esrra estrogen related receptor, alpha decreases expression EXP oxybenzone results in decreased expression of ESRRA mRNA CTD PMID:15458797 NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268 		JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 mRNA]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA] CTD PMID:32407875 PMID:34864131 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Fam180a family with sequence similarity 180, member A decreases expression EXP oxybenzone results in decreased expression of FAM180A mRNA CTD PMID:30316929 NCBI chr 4:63,992,867...64,008,047
Ensembl chr 4:63,992,867...64,008,047 		JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression ISO oxybenzone results in increased expression of FGF2 mRNA CTD PMID:36581016 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Flg filaggrin affects response to substance
multiple interactions		 ISO FLG gene mutant form affects the susceptibility to oxybenzone
[FLG gene mutant form affects the susceptibility to oxybenzone] which results in decreased secretion of FSHB protein; [FLG gene mutant form affects the susceptibility to oxybenzone] which results in increased secretion of Estradiol; [FLG gene mutant form affects the susceptibility to oxybenzone] which results in increased secretion of Testosterone		 CTD PMID:30245359 NCBI chr 2:178,884,793...178,912,986 JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO [oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of FN1 mRNA CTD PMID:38387520 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Foxl2 forkhead box L2 increases expression
multiple interactions		 EXP oxybenzone results in increased expression of FOXL2 mRNA
4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol inhibits the reaction [oxybenzone results in increased expression of FOXL2 mRNA]		 CTD PMID:30599193 NCBI chr 8:99,512,971...99,514,500
Ensembl chr 8:99,513,303...99,514,427 		JBrowse link
G Frzb frizzled-related protein decreases expression EXP oxybenzone results in decreased expression of FRZB mRNA CTD PMID:30316929 NCBI chr 3:65,332,274...65,365,208
Ensembl chr 3:65,332,277...65,365,208 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO [FLG gene mutant form affects the susceptibility to oxybenzone] which results in decreased secretion of FSHB protein CTD PMID:30245359 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Fst follistatin increases expression EXP oxybenzone results in increased expression of FST mRNA CTD PMID:30599193 NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571 		JBrowse link
G Garin1a golgi associated RAB2 interactor 1A decreases expression EXP oxybenzone results in decreased expression of GARIN1A mRNA CTD PMID:30316929 NCBI chr 4:57,880,019...57,890,824
Ensembl chr 4:57,880,019...57,890,820 		JBrowse link
G Garin3 golgi associated RAB2 interactor family member 3 decreases expression EXP oxybenzone results in decreased expression of GARIN3 mRNA CTD PMID:30316929 NCBI chr10:30,829,877...30,833,115
Ensembl chr10:30,829,877...30,833,111 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 affects expression EXP oxybenzone affects the expression of GPER1 protein CTD PMID:30099065 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889 		JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions
increases expression		 ISO Fulvestrant inhibits the reaction [oxybenzone results in increased expression of GREB1 mRNA] CTD PMID:33405908 NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 affects expression EXP oxybenzone affects the expression of GRIN1 protein CTD PMID:31368502 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A affects expression EXP oxybenzone affects the expression of GRIN2A protein CTD PMID:31368502 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 decreases expression EXP oxybenzone results in decreased expression of GSTA2 mRNA CTD PMID:30316929 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 decreases expression EXP oxybenzone results in decreased expression of GSTA5 mRNA CTD PMID:30316929 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression EXP oxybenzone results in increased expression of GSTM1 mRNA CTD PMID:30316929 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP oxybenzone results in increased expression of GSTP1 mRNA CTD PMID:30316929 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Gstt2 glutathione S-transferase theta 2 increases expression EXP oxybenzone results in increased expression of GSTT2 mRNA CTD PMID:30316929 NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288 		JBrowse link
G Gstt4 glutathione S-transferase, theta 4 decreases expression EXP oxybenzone results in decreased expression of GSTT4 mRNA CTD PMID:30316929 NCBI chr20:12,835,178...12,842,306
Ensembl chr20:12,835,178...12,842,292 		JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions		 ISO oxybenzone results in increased expression of H2AX protein modified form
Fulvestrant inhibits the reaction [oxybenzone results in increased expression of H2AX protein modified form]		 CTD PMID:31939680 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha decreases expression EXP oxybenzone results in decreased expression of HADHA mRNA CTD PMID:30316929 NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869 		JBrowse link
G Hdac1 histone deacetylase 1 increases expression EXP oxybenzone results in increased expression of HDAC1 protein CTD PMID:31368502 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hdac2 histone deacetylase 2 increases expression EXP oxybenzone results in increased expression of HDAC2 protein CTD PMID:31368502 NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Hdac9 histone deacetylase 9 increases expression ISO oxybenzone results in increased expression of HDAC9 mRNA CTD PMID:36581016 NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
multiple interactions		 ISO oxybenzone results in increased expression of HIF1A mRNA
[oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of HIF1A mRNA		 CTD PMID:36581016 PMID:38387520 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hltf helicase-like transcription factor increases expression ISO oxybenzone results in increased expression of HLTF mRNA CTD PMID:36581016 NCBI chr 2:102,549,724...102,609,492
Ensembl chr 2:102,549,724...102,609,327 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO oxybenzone results in increased expression of HMGCR mRNA CTD PMID:32407875 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO oxybenzone results in increased expression of HMGCS1 mRNA CTD PMID:32407875 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression EXP oxybenzone results in decreased expression of HMGCS2 mRNA CTD PMID:30316929 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130 		JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 decreases expression EXP oxybenzone results in decreased expression of HSD17B10 mRNA CTD PMID:30316929 NCBI chr  X:21,089,142...21,091,603
Ensembl chr  X:21,089,122...21,109,488 		JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 decreases activity EXP oxybenzone results in decreased activity of HSD3B2 protein CTD PMID:37217011 NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852 		JBrowse link
G Hsdl2 hydroxysteroid dehydrogenase like 2 decreases expression EXP oxybenzone results in decreased expression of HSDL2 mRNA CTD PMID:30316929 NCBI chr 5:74,443,933...74,479,104
Ensembl chr 5:74,443,872...74,479,839 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression ISO oxybenzone results in increased expression of HSP90AA1 mRNA CTD PMID:36581016 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268 		JBrowse link
G Hykk hydroxylysine kinase increases expression EXP oxybenzone results in increased expression of HYKK mRNA CTD PMID:30316929 NCBI chr 8:55,315,919...55,339,720
Ensembl chr 8:55,315,969...55,337,339 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 decreases expression EXP oxybenzone results in decreased expression of IDH2 mRNA CTD PMID:30316929 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025 		JBrowse link
G Idh3g isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma increases expression EXP oxybenzone results in increased expression of IDH3G mRNA CTD PMID:30316929 NCBI chr  X:151,515,244...151,524,175
Ensembl chr  X:151,515,247...151,524,171 		JBrowse link
G Il19 interleukin 19 increases expression EXP oxybenzone results in increased expression of IL19 mRNA CTD PMID:30316929 NCBI chr13:42,397,715...42,411,637
Ensembl chr13:42,399,138...42,405,473 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ mRNA]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ protein]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA] CTD PMID:32407875 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ mRNA]; oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ protein]; oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 mRNA]; oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of PPARG mRNA] CTD PMID:34864131 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Iqcf6 IQ motif containing F6 decreases expression EXP oxybenzone results in decreased expression of IQCF6 mRNA CTD PMID:30316929 NCBI chr 8:107,263,673...107,264,726
Ensembl chr 8:107,263,654...107,264,724 		JBrowse link
G Itga4 integrin subunit alpha 4 increases expression ISO oxybenzone results in increased expression of ITGA4 mRNA CTD PMID:36581016 NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715 		JBrowse link
G Kras KRAS proto-oncogene, GTPase increases expression ISO oxybenzone results in increased expression of KRAS mRNA CTD PMID:36581016 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Krt18 keratin 18 decreases expression EXP oxybenzone results in decreased expression of KRT18 mRNA CTD PMID:30316929 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase decreases expression ISO oxybenzone results in decreased expression of LCK mRNA CTD PMID:36581016 NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794 		JBrowse link
G Ldhd lactate dehydrogenase D increases methylation ISO oxybenzone results in increased methylation of LDHD gene CTD PMID:34523531 NCBI chr19:39,583,529...39,588,397
Ensembl chr19:39,573,621...39,595,575 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 multiple interactions ISO [oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of LEF1 mRNA CTD PMID:38387520 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794 		JBrowse link
G Lifr LIF receptor subunit alpha increases expression ISO oxybenzone results in increased expression of LIFR mRNA CTD PMID:36581016 NCBI chr 2:56,224,393...56,292,988
Ensembl chr 2:56,250,120...56,286,699 		JBrowse link
G Lsmem1 leucine-rich single-pass membrane protein 1 increases expression EXP oxybenzone results in increased expression of LSMEM1 mRNA CTD PMID:30316929 NCBI chr 6:57,251,720...57,261,590
Ensembl chr 6:57,252,056...57,261,653 		JBrowse link
G Magel2 MAGE family member L2 increases expression EXP oxybenzone results in increased expression of MAGEL2 mRNA CTD PMID:30316929 NCBI chr 1:115,880,142...115,884,684
Ensembl chr 1:115,880,474...115,884,250 		JBrowse link
G Mapk6 mitogen-activated protein kinase 6 increases expression ISO oxybenzone results in increased expression of MAPK6 mRNA CTD PMID:36581016 NCBI chr 8:76,146,650...76,169,767
Ensembl chr 8:76,146,690...76,169,720 		JBrowse link
G Mcc MCC regulator of WNT signaling pathway decreases expression EXP oxybenzone results in decreased expression of MCC mRNA CTD PMID:30316929 NCBI chr18:36,794,206...37,266,237
Ensembl chr18:36,798,372...37,266,819 		JBrowse link
G Med13 mediator complex subunit 13 increases expression ISO oxybenzone results in increased expression of MED13 mRNA CTD PMID:36581016 NCBI chr10:71,086,978...71,176,535
Ensembl chr10:71,090,516...71,177,242 		JBrowse link
G Medag mesenteric estrogen-dependent adipogenesis decreases expression EXP oxybenzone results in decreased expression of MEDAG mRNA CTD PMID:30316929 NCBI chr12:5,613,191...5,634,583
Ensembl chr12:5,613,208...5,634,767 		JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease increases expression ISO oxybenzone results in increased expression of MRE11 mRNA CTD PMID:36581016 NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279 		JBrowse link
G Msh2 mutS homolog 2 increases expression ISO oxybenzone results in increased expression of MSH2 mRNA CTD PMID:36581016 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Mybl1 MYB proto-oncogene like 1 increases expression
multiple interactions		 ISO oxybenzone results in increased expression of MYBL1 mRNA
Fulvestrant inhibits the reaction [oxybenzone results in increased expression of MYBL1 mRNA]		 CTD PMID:33405908 NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183 		JBrowse link
G Nbn nibrin increases expression ISO oxybenzone results in increased expression of NBN mRNA CTD PMID:36581016 NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions
increases expression		 ISO oxybenzone promotes the reaction [NCOA2 protein binds to PPARG protein]
oxybenzone results in increased expression of NCOA2 mRNA		 CTD PMID:32407875 PMID:36581016 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Ndufa11 NADH:ubiquinone oxidoreductase subunit A11 decreases expression EXP oxybenzone results in decreased expression of NDUFA11 mRNA CTD PMID:30316929 NCBI chr 9:1,550,487...1,554,546
Ensembl chr 9:1,550,468...1,555,601 		JBrowse link
G Ndufa3 NADH:ubiquinone oxidoreductase subunit A3 decreases expression EXP oxybenzone results in decreased expression of NDUFA3 mRNA CTD PMID:30316929 NCBI chr 1:65,597,567...65,600,197
Ensembl chr 1:65,597,578...65,600,235 		JBrowse link
G Ndufa9 NADH:ubiquinone oxidoreductase subunit A9 increases expression EXP oxybenzone results in increased expression of NDUFA9 mRNA CTD PMID:30316929 NCBI chr 4:159,659,242...159,688,034
Ensembl chr 4:159,659,242...159,688,018 		JBrowse link
G Ndufab1 NADH:ubiquinone oxidoreductase subunit AB1 increases expression EXP oxybenzone results in increased expression of NDUFAB1 mRNA CTD PMID:30316929 NCBI chr 1:176,644,696...176,658,131
Ensembl chr 1:176,644,703...176,658,099 		JBrowse link
G Ndufb10 NADH:ubiquinone oxidoreductase subunit B10 increases expression EXP oxybenzone results in increased expression of NDUFB10 mRNA CTD PMID:30316929 NCBI chr10:13,749,273...13,751,434
Ensembl chr10:13,749,275...13,751,442 		JBrowse link
G Ndufb7 NADH:ubiquinone oxidoreductase subunit B7 increases expression EXP oxybenzone results in increased expression of NDUFB7 mRNA CTD PMID:30316929 NCBI chr19:24,568,241...24,572,579
Ensembl chr19:24,568,241...24,572,579 		JBrowse link
G Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 decreases expression EXP oxybenzone results in decreased expression of NDUFS2 mRNA CTD PMID:30316929 NCBI chr13:83,654,402...83,671,474
Ensembl chr13:83,654,406...83,671,420 		JBrowse link
G Ndufv3 NADH:ubiquinone oxidoreductase subunit V3 affects expression EXP oxybenzone affects the expression of NDUFV3 mRNA CTD PMID:30316929 NCBI chr20:9,612,462...9,621,622
Ensembl chr20:9,612,431...9,623,074
Ensembl chr13:9,612,431...9,623,074 		JBrowse link
G Nf1 neurofibromin 1 increases expression ISO oxybenzone results in increased expression of NF1 mRNA CTD PMID:36581016 NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658 		JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 increases expression ISO oxybenzone results in increased expression of NFAT5 mRNA CTD PMID:36581016 NCBI chr19:35,199,737...35,286,675
Ensembl chr19:35,199,016...35,286,675 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO oxybenzone binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO oxybenzone results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases expression ISO oxybenzone results in increased expression of NR3C1 mRNA CTD PMID:36581016 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Nrf1 nuclear respiratory factor 1 increases expression EXP oxybenzone results in increased expression of NRF1 mRNA CTD PMID:30316929 NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328 		JBrowse link
G Nrip1 nuclear receptor interacting protein 1 increases expression ISO oxybenzone results in increased expression of NRIP1 mRNA CTD PMID:36581016 NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761 		JBrowse link
G Ntn5 netrin 5 increases expression EXP oxybenzone results in increased expression of NTN5 mRNA CTD PMID:30316929 NCBI chr 1:96,156,948...96,165,997
Ensembl chr 1:96,156,985...96,165,630 		JBrowse link
G Ogdh oxoglutarate dehydrogenase increases expression
decreases expression		 EXP oxybenzone results in increased expression of OGDH mRNA
oxybenzone results in decreased expression of OGDH mRNA		 CTD PMID:30316929 NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479 		JBrowse link
G Pdcd11 programmed cell death 11 increases expression EXP oxybenzone results in increased expression of PDCD11 mRNA CTD PMID:30316929 NCBI chr 1:245,980,840...246,021,999
Ensembl chr 1:245,980,880...246,021,999 		JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein decreases expression EXP oxybenzone results in decreased expression of PDCD6IP mRNA CTD PMID:30316929 NCBI chr 8:113,590,998...113,646,795
Ensembl chr 8:113,590,998...113,646,773 		JBrowse link
G Pdcd7 programmed cell death 7 increases expression EXP oxybenzone results in increased expression of PDCD7 mRNA CTD PMID:30316929 NCBI chr 8:65,862,606...65,877,333
Ensembl chr 8:65,862,387...65,877,333 		JBrowse link
G Pgr progesterone receptor multiple interactions
decreases expression
increases expression		 ISO oxybenzone binds to and results in decreased activity of PGR protein
oxybenzone results in decreased expression of PGR mRNA
oxybenzone results in increased expression of PGR mRNA		 CTD PMID:15537743 PMID:31939680 PMID:32946892 PMID:38382712 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Phf24 PHD finger protein 24 increases expression EXP oxybenzone results in increased expression of PHF24 mRNA CTD PMID:30316929 NCBI chr 5:57,143,428...57,171,054
Ensembl chr 5:57,142,632...57,168,497 		JBrowse link
G Pias1 protein inhibitor of activated STAT, 1 increases expression ISO oxybenzone results in increased expression of PIAS1 mRNA CTD PMID:36581016 NCBI chr 8:63,338,150...63,451,670
Ensembl chr 8:63,338,150...63,438,905 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 increases expression ISO oxybenzone results in increased expression of PIK3R1 mRNA CTD PMID:36581016 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Polm DNA polymerase mu decreases expression EXP oxybenzone results in decreased expression of POLM mRNA CTD PMID:30316929 NCBI chr14:80,707,075...80,716,677
Ensembl chr14:80,706,345...80,717,086 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO oxybenzone results in increased expression of PPARA mRNA CTD PMID:32407875 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects binding
multiple interactions
increases expression		 ISO oxybenzone binds to PPARG protein
oxybenzone binds to and results in increased activity of PPARG protein
oxybenzone binds to and results in increased activity of PPARG protein; oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of PPARG mRNA]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA]; oxybenzone promotes the reaction [NCOA2 protein binds to PPARG protein]
oxybenzone results in increased expression of PPARG mRNA		 CTD PMID:32407875 PMID:33049310 PMID:34864131 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppp1cb protein phosphatase 1 catalytic subunit beta increases expression ISO oxybenzone results in increased expression of PPP1CB mRNA CTD PMID:36581016 NCBI chr 6:23,958,813...23,992,841
Ensembl chr 6:23,960,998...23,992,824 		JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta increases expression ISO oxybenzone results in increased expression of PRKACB mRNA CTD PMID:36581016 NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198 		JBrowse link
G Prkci protein kinase C, iota increases expression ISO oxybenzone results in increased expression of PRKCI mRNA CTD PMID:36581016 NCBI chr 2:112,321,919...112,382,305
Ensembl chr 2:112,321,929...112,382,352 		JBrowse link
G Prss37 serine protease 37 decreases expression EXP oxybenzone results in decreased expression of PRSS37 mRNA CTD PMID:30316929 NCBI chr 4:69,322,977...69,334,555
Ensembl chr 4:69,322,977...69,334,555 		JBrowse link
G Pten phosphatase and tensin homolog increases expression ISO oxybenzone results in increased expression of PTEN mRNA CTD PMID:36581016 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO oxybenzone results in increased expression of PTGS2 mRNA CTD PMID:36581016 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptpn4 protein tyrosine phosphatase, non-receptor type 4 increases expression ISO oxybenzone results in increased expression of PTPN4 mRNA CTD PMID:36581016 NCBI chr13:30,772,012...30,952,340
Ensembl chr13:30,776,682...30,952,170 		JBrowse link
G Rad17 RAD17 checkpoint clamp loader component increases expression ISO oxybenzone results in increased expression of RAD17 mRNA CTD PMID:36581016 NCBI chr 2:31,764,260...31,794,542
Ensembl chr 2:31,764,261...31,794,072 		JBrowse link
G Rad50 RAD50 double strand break repair protein increases expression ISO oxybenzone results in increased expression of RAD50 mRNA CTD PMID:36581016 NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396 		JBrowse link
G Rap2a RAP2A, member of RAS oncogene family increases expression ISO oxybenzone results in increased expression of RAP2A mRNA CTD PMID:36581016 NCBI chr15:97,596,848...97,597,338
Ensembl chr15:97,596,020...97,624,138 		JBrowse link
G Rb1 RB transcriptional corepressor 1 increases expression ISO oxybenzone results in increased expression of RB1 mRNA CTD PMID:36581016 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rb1cc1 RB1-inducible coiled-coil 1 increases expression ISO oxybenzone results in increased expression of RB1CC1 mRNA CTD PMID:36581016 NCBI chr 5:13,161,648...13,225,560
Ensembl chr 5:13,161,648...13,225,560 		JBrowse link
G Rbbp8 RB binding protein 8, endonuclease increases expression ISO oxybenzone results in increased expression of RBBP8 mRNA CTD PMID:36581016 NCBI chr18:2,922,985...2,988,851
Ensembl chr18:2,921,286...2,988,846 		JBrowse link
G Rbl1 RB transcriptional corepressor like 1 increases expression ISO oxybenzone results in increased expression of RBL1 mRNA CTD PMID:36581016 NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330 		JBrowse link
G Rel REL proto-oncogene, NF-kB subunit increases expression ISO oxybenzone results in increased expression of REL mRNA CTD PMID:36581016 NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression EXP oxybenzone results in increased expression of RELA protein CTD PMID:31368502 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Retn resistin decreases expression EXP oxybenzone results in decreased expression of RETN mRNA CTD PMID:30316929 NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620 		JBrowse link
G Rfc1 replication factor C subunit 1 increases expression ISO oxybenzone results in increased expression of RFC1 mRNA CTD PMID:36581016 NCBI chr14:42,966,279...43,041,372
Ensembl chr14:42,966,324...43,041,370 		JBrowse link
G Rictor RPTOR independent companion of MTOR, complex 2 increases expression ISO oxybenzone results in increased expression of RICTOR mRNA CTD PMID:36581016 NCBI chr 2:55,811,877...55,903,893
Ensembl chr 2:55,811,322...55,901,426 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 increases expression ISO oxybenzone results in increased expression of ROCK1 mRNA CTD PMID:36581016 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571 		JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 increases expression ISO oxybenzone results in increased expression of ROCK2 mRNA CTD PMID:36581016 NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 increases expression ISO oxybenzone results in increased expression of RPS6KB1 mRNA CTD PMID:36581016 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B increases expression ISO oxybenzone results in increased expression of RRM2B mRNA CTD PMID:36581016 NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633 		JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A increases expression EXP oxybenzone results in increased expression of SDHA mRNA CTD PMID:30316929 NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535 		JBrowse link
G Serpinc1 serpin family C member 1 increases expression EXP oxybenzone results in increased expression of SERPINC1 mRNA CTD PMID:30316929 NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 multiple interactions
increases expression		 ISO Fulvestrant inhibits the reaction [oxybenzone results in increased expression of SGK1 mRNA] CTD PMID:33405908 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283 		JBrowse link
G Sh3glb1 SH3 domain -containing GRB2-like endophilin B1 increases expression EXP oxybenzone results in increased expression of SH3GLB1 mRNA CTD PMID:30316929 NCBI chr 2:233,750,838...233,784,817
Ensembl chr 2:233,750,838...233,784,784 		JBrowse link
G Shank1 SH3 and multiple ankyrin repeat domains 1 increases expression EXP oxybenzone results in increased expression of SHANK1 mRNA CTD PMID:30316929 NCBI chr 1:94,807,879...94,857,356
Ensembl chr 1:94,808,276...94,855,824 		JBrowse link
G Slc1a2 solute carrier family 1 member 2 affects expression EXP oxybenzone affects the expression of SLC1A2 protein CTD PMID:31368502 NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 affects expression EXP oxybenzone affects the expression of SLC7A11 protein CTD PMID:31368502 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Smc3 structural maintenance of chromosomes 3 increases expression ISO oxybenzone results in increased expression of SMC3 mRNA CTD PMID:36581016 NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522 		JBrowse link
G Sox9 SRY-box transcription factor 9 multiple interactions
increases expression		 EXP 4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol inhibits the reaction [oxybenzone results in increased expression of SOX9 mRNA] CTD PMID:30599193 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994 		JBrowse link
G Sstr3 somatostatin receptor 3 increases expression EXP oxybenzone results in increased expression of SSTR3 mRNA CTD PMID:30316929 NCBI chr 7:110,092,563...110,109,043
Ensembl chr 7:110,092,575...110,099,769 		JBrowse link
G Stag1 STAG1 cohesin complex component increases expression ISO oxybenzone results in increased expression of STAG1 mRNA CTD PMID:36581016 NCBI chr 8:101,179,039...101,564,684
Ensembl chr 8:101,179,039...101,564,677 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A increases expression
affects localization		 ISO oxybenzone results in increased expression of STAT5A mRNA
oxybenzone affects the localization of STAT5A protein		 CTD PMID:32946892 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases expression EXP oxybenzone results in decreased expression of SULT1A1 mRNA CTD PMID:30316929 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Taf9b TATA-box binding protein associated factor 9b increases expression ISO oxybenzone results in increased expression of TAF9B mRNA CTD PMID:36581016 NCBI chr  X:71,289,290...71,300,142
Ensembl chr  X:71,289,290...71,300,604 		JBrowse link
G Tbk1 TANK-binding kinase 1 increases expression ISO oxybenzone results in increased expression of TBK1 mRNA CTD PMID:36581016 NCBI chr 7:57,077,830...57,110,868
Ensembl chr 7:57,077,830...57,110,892 		JBrowse link
G Tex46 testis expressed 46 decreases expression EXP oxybenzone results in decreased expression of TEX46 mRNA CTD PMID:30316929 NCBI chr 5:148,849,307...148,853,742
Ensembl chr 5:148,849,307...148,853,742 		JBrowse link
G Tfam transcription factor A, mitochondrial increases expression EXP
ISO		 oxybenzone results in increased expression of TFAM mRNA CTD PMID:30316929 PMID:36581016 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292 		JBrowse link
G Tff1 trefoil factor 1 multiple interactions
increases expression		 ISO [oxybenzone co-treated with 2,4-dihydroxybenzophenone co-treated with octylmethoxycinnamate co-treated with enzacamene] results in increased expression of TFF1 mRNA; [oxybenzone co-treated with 2,4-dihydroxybenzophenone] results in increased expression of TFF1 mRNA
oxybenzone results in increased expression of TFF1 mRNA		 CTD PMID:16183391 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [oxybenzone co-treated with Dietary Fats analog] results in decreased expression of TGFB1 mRNA; [oxybenzone co-treated with Dietary Fats] results in decreased expression of TGFB1 mRNA CTD PMID:38387520 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 increases expression ISO oxybenzone results in increased expression of TGFBR1 mRNA CTD PMID:36581016 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions
decreases expression		 ISO [oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of TIMP1 mRNA; [oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of TIMP1 protein
oxybenzone results in decreased expression of TIMP1 mRNA		 CTD PMID:38387520 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tmprss4 transmembrane serine protease 4 increases expression EXP oxybenzone results in increased expression of TMPRSS4 mRNA CTD PMID:30316929 NCBI chr 8:45,475,819...45,508,409
Ensembl chr 8:45,476,053...45,508,409 		JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases expression ISO oxybenzone results in decreased expression of TNFSF11 mRNA CTD PMID:38382712 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Topbp1 DNA topoisomerase II binding protein 1 increases expression ISO oxybenzone results in increased expression of TOPBP1 mRNA CTD PMID:36581016 NCBI chr 8:103,887,805...103,931,662
Ensembl chr 8:103,887,865...103,931,674 		JBrowse link
G Tp53 tumor protein p53 decreases expression EXP oxybenzone results in decreased expression of TP53 mRNA CTD PMID:30316929 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 increases expression ISO oxybenzone results in increased expression of TP53BP1 protein CTD PMID:31939680 NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822 		JBrowse link
G Tpr translocated promoter region, nuclear basket protein increases expression ISO oxybenzone results in increased expression of TPR mRNA CTD PMID:36581016 NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496 		JBrowse link
G Tspo translocator protein decreases expression EXP oxybenzone results in decreased expression of TSPO mRNA CTD PMID:30316929 NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 multiple interactions ISO [oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of TWIST1 mRNA; [oxybenzone co-treated with Dietary Fats analog] results in decreased expression of TWIST1 mRNA CTD PMID:38387520 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 decreases expression EXP oxybenzone results in decreased expression of UGT1A6 mRNA CTD PMID:30316929 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2a3 UDP glucuronosyltransferase family 2 member A3 decreases expression EXP oxybenzone results in decreased expression of UGT2A3 mRNA CTD PMID:30316929 NCBI chr14:20,572,793...20,590,795
Ensembl chr14:20,572,808...20,590,729 		JBrowse link
G Upk1b uroplakin 1B decreases expression EXP oxybenzone results in decreased expression of UPK1B mRNA CTD PMID:30316929 NCBI chr11:61,953,687...61,991,029
Ensembl chr11:61,953,648...61,991,029 		JBrowse link
G Uqcr11 ubiquinol-cytochrome c reductase, complex III subunit XI affects expression EXP oxybenzone affects the expression of UQCR11 mRNA CTD PMID:30316929 NCBI chr 7:9,305,042...9,309,753
Ensembl chr 7:9,305,058...9,309,750 		JBrowse link
G Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 increases expression EXP oxybenzone results in increased expression of UQCRC1 mRNA CTD PMID:30316929 NCBI chr 8:109,589,735...109,601,481
Ensembl chr 8:109,589,706...109,601,480 		JBrowse link
G Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 decreases expression EXP oxybenzone results in decreased expression of UQCRFS1 mRNA CTD PMID:30316929 NCBI chr17:33,977,908...33,982,478
Ensembl chr17:33,977,921...33,982,479 		JBrowse link
G Uqcrq ubiquinol-cytochrome c reductase, complex III subunit VII increases expression EXP oxybenzone results in increased expression of UQCRQ mRNA CTD PMID:30316929 NCBI chr10:37,585,864...37,589,328
Ensembl chr10:37,586,888...37,589,169 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 decreases expression EXP oxybenzone results in decreased expression of VDAC1 mRNA CTD PMID:30316929 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO [oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of VEGFA mRNA CTD PMID:38387520 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Wnt4 Wnt family member 4 decreases expression ISO oxybenzone results in decreased expression of WNT4 mRNA CTD PMID:38382712 NCBI chr 5:149,513,573...149,535,415
Ensembl chr 5:149,514,018...149,532,859 		JBrowse link
G Wrn WRN RecQ like helicase increases expression ISO oxybenzone results in increased expression of WRN mRNA CTD PMID:36581016 NCBI chr16:58,763,517...58,898,604
Ensembl chr16:58,763,504...58,895,450 		JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 increases expression ISO oxybenzone results in increased expression of ZEB1 mRNA CTD PMID:36581016 NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214 		JBrowse link
G Zfp420 zinc finger protein 420 increases expression ISO oxybenzone results in increased expression of ZNF420 mRNA CTD PMID:36581016 NCBI chr 1:85,092,810...85,143,682
Ensembl chr 1:85,093,085...85,106,693
Ensembl chr 1:85,093,085...85,106,693 		JBrowse link
phenyl salicylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 increases activity
multiple interactions		 ISO phenyl salicylate results in increased activity of ESR1 protein
phenyl salicylate binds to and results in increased activity of ESR1 protein		 CTD PMID:22197706 PMID:24004914 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
scoparone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO scoparone affects the reaction [[Dietary Fats co-treated with Dietary Sugars co-treated with Diethylnitrosamine] results in increased phosphorylation of AKT1 protein] CTD PMID:37436232 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin multiple interactions ISO scoparone inhibits the reaction [[Dietary Fats co-treated with Dietary Sugars co-treated with Diethylnitrosamine] results in decreased expression of ALB protein] CTD PMID:37436232 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO scoparone results in increased expression of BAX protein CTD PMID:37449671 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO scoparone results in decreased expression of BCL2 protein CTD PMID:37449671 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases cleavage ISO scoparone results in increased cleavage of CASP3 protein CTD PMID:37449671 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO scoparone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL2 mRNA]; scoparone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of CCL2 protein]
scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of CCL2 mRNA]]; scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of CCL2 protein]]		 CTD PMID:16376386 PMID:37436232 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cdc42 cell division cycle 42 decreases expression ISO scoparone results in decreased expression of CDC42 mRNA CTD PMID:37449671 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111 		JBrowse link
G Dct dopachrome tautomerase increases expression ISO scoparone results in increased expression of DCT mRNA CTD PMID:17049123 NCBI chr15:95,062,006...95,100,863
Ensembl chr15:95,062,003...95,100,836 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [Dietary Sugars co-treated with Dietary Fats co-treated with scoparone] results in increased expression of GPT protein; scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Sugars co-treated with Dietary Fats] results in increased expression of GPT protein]] CTD PMID:37436232 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO scoparone inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactose] results in increased expression of IFNB1 protein] CTD PMID:23535186 NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO scoparone affects the reaction [[Dietary Fats co-treated with Dietary Sugars co-treated with Diethylnitrosamine] results in increased metabolism of IL1B protein] CTD PMID:37436232 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL6 protein] CTD PMID:23535186 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions ISO scoparone inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactose] results in increased phosphorylation of IRF3 protein] CTD PMID:23535186 NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] affects the localization of and results in increased expression of JUN protein modified form] CTD PMID:23535186 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO scoparone affects the reaction [[Dietary Fats co-treated with Dietary Sugars co-treated with Diethylnitrosamine] results in increased phosphorylation of MAPK14 protein] CTD PMID:37436232 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO scoparone results in decreased expression of MMP2 mRNA CTD PMID:37449671 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions		 ISO scoparone results in decreased expression of MMP9 mRNA
scoparone affects the reaction [[Dietary Fats co-treated with Dietary Sugars co-treated with Diethylnitrosamine] results in increased expression of MMP9 protein]; scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of MMP9 mRNA]]		 CTD PMID:37436232 PMID:37449671 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of MYD88 protein] CTD PMID:23535186 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Myl1 myosin, light chain 1 decreases phosphorylation ISO scoparone results in decreased phosphorylation of MYL1 protein CTD PMID:37449671 NCBI chr 9:68,437,514...68,458,256
Ensembl chr 9:68,437,517...68,458,261 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO scoparone inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of NFKB1 protein] CTD PMID:16376386 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO scoparone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of NFKBIA protein] CTD PMID:16376386 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of NOS2 mRNA]] CTD PMID:37436232 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases expression
increases activity		 ISO scoparone results in increased expression of NR1H4 mRNA
scoparone results in increased activity of NR1H4 protein		 CTD PMID:36542898 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO scoparone results in increased cleavage of PARP1 protein CTD PMID:37449671 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pfkp phosphofructokinase, platelet decreases expression ISO scoparone results in decreased expression of PFKP mRNA CTD PMID:37449671 NCBI chr17:63,729,743...63,794,026
Ensembl chr17:63,729,780...63,794,018 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of PTGS2 mRNA]] CTD PMID:37436232 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions ISO scoparone inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of REL protein] CTD PMID:16376386 NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO scoparone affects the reaction [[Dietary Fats co-treated with Dietary Sugars co-treated with Diethylnitrosamine] results in increased phosphorylation of RELA protein]; scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] affects the localization of and results in increased expression of RELA protein]; scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of RELA mRNA]]; scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of RELA protein]]
scoparone inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of RELA protein]; scoparone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of RELA protein]		 CTD PMID:16376386 PMID:23535186 PMID:37436232 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rhoa ras homolog family member A decreases expression ISO scoparone results in decreased expression of RHOA mRNA; scoparone results in decreased expression of RHOA protein CTD PMID:37449671 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 decreases expression ISO scoparone results in decreased expression of ROCK1 mRNA; scoparone results in decreased expression of ROCK1 protein CTD PMID:37449671 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571 		JBrowse link
G Ticam1 TIR domain containing adaptor molecule 1 multiple interactions ISO scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TICAM1 protein] CTD PMID:23535186 NCBI chr 9:1,102,559...1,111,023
Ensembl chr 9:1,102,366...1,123,147 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR4 protein] CTD PMID:23535186 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TNF protein]; scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of TNF mRNA]]; scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of TNF protein]] CTD PMID:23535186 PMID:37436232 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tyr tyrosinase multiple interactions
increases expression		 ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [scoparone results in increased expression of TYR protein]; scoparone results in increased expression of and results in increased activity of TYR protein
scoparone results in increased expression of TYR mRNA		 CTD PMID:17049123 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
G Tyrp1 tyrosinase-related protein 1 increases expression ISO scoparone results in increased expression of TYRP1 mRNA CTD PMID:17049123 NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516 		JBrowse link
thiourea term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein increases uptake ISO Thiourea results in increased uptake of APP protein modified form CTD PMID:20637185 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Aqp1 aquaporin 1 decreases expression EXP Thiourea results in decreased expression of AQP1 mRNA CTD PMID:15248066 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690 		JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) increases expression EXP Thiourea results in increased expression of AQP3 mRNA CTD PMID:15248066 NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720 		JBrowse link
G Aqp4 aquaporin 4 decreases expression EXP Thiourea results in decreased expression of AQP4 mRNA CTD PMID:15248066 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856 		JBrowse link
G Aqp5 aquaporin 5 decreases expression EXP Thiourea results in decreased expression of AQP5 mRNA CTD PMID:15248066 NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209 		JBrowse link
G Aqp9 aquaporin 9 increases uptake EXP AQP9 protein results in increased uptake of Thiourea CTD PMID:9733774 NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Thiourea inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of BAX protein] CTD PMID:29803612 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO Thiourea analog results in decreased activity of CA1 protein CTD PMID:28117934 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208 		JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Thiourea analog results in decreased activity of CA2 protein CTD PMID:28117934 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO		 Thiourea analog inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]
Thiourea inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased activity of CASP3 protein]		 CTD PMID:14599462 PMID:29803612 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cftr CF transmembrane conductance regulator decreases expression EXP Thiourea results in decreased expression of CFTR mRNA CTD PMID:15248066 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 increases metabolic processing ISO FMO2 protein results in increased metabolism of Thiourea CTD PMID:12214664 NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308 		JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 multiple interactions
increases response to substance		 ISO Buthionine Sulfoximine inhibits the reaction [FMO3 protein results in increased susceptibility to Thiourea] CTD PMID:12093470 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Thiourea inhibits the reaction [tert-Butylhydroperoxide results in increased expression of FOS mRNA] CTD PMID:15105052 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP Thiourea inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR mRNA]; Thiourea inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR protein] CTD PMID:19931295 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Thiourea analog inhibits the reaction [IFNG protein promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of SPP1 mRNA]] CTD PMID:10868913 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Thiourea inhibits the reaction [cadmium acetate results in increased secretion of IL6 protein]; Thiourea inhibits the reaction [Particulate Matter results in increased expression of IL6 mRNA]; Thiourea inhibits the reaction [sodium arsenite results in increased secretion of IL6 protein]; Thiourea inhibits the reaction [Vehicle Emissions results in increased expression of IL6 mRNA]; Thiourea inhibits the reaction [zinc chloride results in increased secretion of IL6 protein] CTD PMID:26160521 PMID:27427241 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Thiourea inhibits the reaction [tert-Butylhydroperoxide results in increased expression of JUN mRNA] CTD PMID:15105052 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions		 ISO Thiourea analog results in decreased expression of NOS2 mRNA; Thiourea analog results in decreased expression of NOS2 protein; Thiourea results in decreased expression of NOS2 protein
[Thiourea analog results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; Thiourea results in decreased susceptibility to [Lipopolysaccharides results in increased expression of NOS2 protein]		 CTD PMID:17467989 PMID:20637185 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions		 ISO Thiourea results in decreased expression of PTGS2 protein
Thiourea results in decreased susceptibility to [Lipopolysaccharides results in increased expression of PTGS2 protein]		 CTD PMID:20637185 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha decreases expression EXP Thiourea results in decreased expression of SCNN1A mRNA CTD PMID:15248066 NCBI chr 4:158,122,962...158,146,184
Ensembl chr 4:158,122,962...158,146,181 		JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta decreases expression EXP Thiourea results in decreased expression of SCNN1B mRNA CTD PMID:15248066 NCBI chr 1:176,430,063...176,484,451
Ensembl chr 1:176,430,103...176,484,451 		JBrowse link
G Scnn1g sodium channel epithelial 1 subunit gamma decreases expression EXP Thiourea results in decreased expression of SCNN1G mRNA CTD PMID:15248066 NCBI chr 1:176,304,942...176,338,816
Ensembl chr 1:176,304,942...176,338,816 		JBrowse link
G Slc14a1 solute carrier family 14 member 1 (Kidd blood group) multiple interactions ISO Thiourea inhibits the reaction [SLC14A1 protein affects the transport of Urea] CTD PMID:17506977 NCBI chr18:71,565,453...71,608,807
Ensembl chr18:71,565,454...71,595,146 		JBrowse link
G Slc14a2 solute carrier family 14 member 2 multiple interactions EXP Thiourea analog inhibits the reaction [SLC14A2 protein results in increased transport of Urea] CTD PMID:11181411 NCBI chr18:71,612,460...72,039,462
Ensembl chr18:71,612,460...71,792,968 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO Thiourea analog inhibits the reaction [IFNG protein promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of SPP1 mRNA]] CTD PMID:10868913 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Thiourea inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of TP53 protein] CTD PMID:29803612 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
trans-urocanic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flg filaggrin decreases abundance ISO FLG mutant form results in decreased abundance of Urocanic Acid CTD PMID:24061166 NCBI chr 2:178,884,793...178,912,986 JBrowse link
G Ifng interferon gamma multiple interactions ISO IFNG protein affects the susceptibility to [Permethrin co-treated with Urocanic Acid] CTD PMID:14617103 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Tnf tumor necrosis factor affects response to substance ISO TNF protein affects the susceptibility to Urocanic Acid CTD PMID:14617103 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
urocanic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flg filaggrin decreases abundance ISO FLG mutant form results in decreased abundance of Urocanic Acid CTD PMID:24061166 NCBI chr 2:178,884,793...178,912,986 JBrowse link
G Ifng interferon gamma multiple interactions ISO IFNG protein affects the susceptibility to [Permethrin co-treated with Urocanic Acid] CTD PMID:14617103 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Tnf tumor necrosis factor affects response to substance ISO TNF protein affects the susceptibility to Urocanic Acid CTD PMID:14617103 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
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  CHEBI ontology 19932
    role 19904
      chemical role 19529
        photochemical role 331
          chromophore + 55
          lumiphore 0
          photobiochemical role + 0
          ultraviolet filter + 302
paths to the root