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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:photochemical role
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Accession:CHEBI:52215 term browser browse the term
Definition:A chemical role played by the molecular entity or part thereof in a photochemical process.
Synonyms:related_synonym: photochemical roles


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3,6-diaminoacridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Proflavine inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:30818834 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO Proflavine results in increased activity of ESR1 protein CTD PMID:30818834 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions ISO Proflavine inhibits the reaction [XCT790 results in decreased activity of ESRRA protein] CTD PMID:30818834 NCBI chr 1:222,168,729...222,178,842
Ensembl chr 1:222,168,730...222,178,725
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Proflavine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity ISO Proflavine results in increased activity of NFE2L2 protein CTD PMID:30818834 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Proflavine inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; Proflavine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666, PMID:30818834 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Proflavine inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of NR1I3 protein] CTD PMID:30818834 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Proflavine inhibits the reaction [Promegestone results in increased activity of PGR protein] CTD PMID:30818834 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Proflavine inhibits the reaction [Rosiglitazone results in increased activity of PPARG protein] CTD PMID:30818834 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Tp53 tumor protein p53 increases activity ISO Proflavine results in increased activity of TP53 protein CTD PMID:30818834 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
alizarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO alizarin results in decreased activity of CYP1A1 protein CTD PMID:12379470 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO alizarin results in decreased activity of CYP1A2 protein CTD PMID:12379470 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO alizarin results in decreased activity of CYP1B1 protein CTD PMID:12379470 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO alizarin results in decreased activity of CYP2E1 protein CTD PMID:12379470 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO alizarin binds to and results in increased activity of ESR1 protein CTD PMID:20707409 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of alizarin CTD PMID:14557274 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of alizarin CTD PMID:14557274 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of alizarin CTD PMID:14557274 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of alizarin CTD PMID:7574722 NCBI chr14:22,375,428...22,486,291
Ensembl chr14:22,375,955...22,534,720
JBrowse link
esculetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGTR1A mRNA]; esculetin inhibits the reaction [Dietary Fats results in increased expression of AGTR1A mRNA] CTD PMID:28946194 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions EXP esculetin inhibits the reaction [Dietary Fats results in increased expression of AGTR2 mRNA]; esculetin promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGTR2 mRNA] CTD PMID:28946194 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO esculetin results in increased phosphorylation of AKT1 protein CTD PMID:24995577 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alox15 arachidonate 15-lipoxygenase decreases expression ISO esculetin results in decreased expression of ALOX15 protein CTD PMID:30171828 NCBI chr10:56,953,692...56,962,145
Ensembl chr10:56,953,691...56,962,161
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO esculetin results in increased expression of BAK1 protein CTD PMID:26388407 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
affects expression
affects localization
ISO [esculetin co-treated with Paclitaxel] results in increased expression of BAX protein
esculetin results in increased expression of BAX protein
esculetin affects the expression of BAX protein
esculetin affects the localization of BAX protein
CTD PMID:16051289, PMID:19786087, PMID:24995577, PMID:26388407, PMID:31313495 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression
decreases expression
ISO esculetin affects the expression of BCL2 protein
esculetin results in decreased expression of BCL2 protein
CTD PMID:24995577, PMID:26388407, PMID:31313495 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression
ISO [esculetin co-treated with Paclitaxel] results in decreased expression of BCL2L1 protein
esculetin results in decreased expression of BCL2L1 protein
CTD PMID:16051289, PMID:26388407 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [arsenic trioxide co-treated with esculetin] results in increased cleavage of BID protein CTD PMID:19428345 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Bmp6 bone morphogenetic protein 6 multiple interactions EXP esculetin inhibits the reaction [Streptozocin results in decreased expression of BMP6 mRNA] CTD PMID:21450970 NCBI chr17:26,955,142...27,112,820
Ensembl chr17:26,955,142...27,112,820
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
ISO [esculetin co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP3 protein
esculetin results in increased cleavage of CASP3 protein
esculetin results in increased activity of CASP3 protein
CTD PMID:16051289, PMID:24995577, PMID:26388407, PMID:31313495 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases cleavage ISO esculetin results in increased cleavage of CASP7 protein CTD PMID:31313495 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [esculetin co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:16051289 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity
increases cleavage
ISO esculetin results in increased activity of CASP9 protein
esculetin results in increased cleavage of CASP9 protein
CTD PMID:24995577, PMID:26388407, PMID:31313495 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of CCL2 protein] CTD PMID:27769711 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccnd1 cyclin D1 decreases expression EXP
ISO
esculetin results in decreased expression of CCND1 protein CTD PMID:21600278, PMID:31313495 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression
multiple interactions
EXP esculetin results in decreased expression of CDK2 protein
esculetin promotes the reaction [CDKN1A protein binds to CDK2 protein]; SB 203580 inhibits the reaction [esculetin results in decreased expression of CDK2 protein]
CTD PMID:21600278 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression
multiple interactions
EXP esculetin results in decreased expression of CDK4 protein
esculetin promotes the reaction [CDKN1A protein binds to CDK4 protein]; SB 203580 inhibits the reaction [esculetin results in decreased expression of CDK4 protein]
CTD PMID:21600278 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
EXP
ISO
esculetin promotes the reaction [CDKN1A protein binds to CDK2 protein]; esculetin promotes the reaction [CDKN1A protein binds to CDK4 protein]; SB 203580 inhibits the reaction [esculetin results in increased expression of CDKN1A protein] CTD PMID:21600278, PMID:31313495 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO esculetin results in increased expression of CDKN1B protein CTD PMID:31313495 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Comt catechol-O-methyltransferase increases methylation ISO COMT protein results in increased methylation of esculetin CTD PMID:11160877 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [arsenic trioxide co-treated with esculetin] affects the localization of CYCS protein; [esculetin co-treated with Paclitaxel] affects the localization of CYCS protein CTD PMID:16051289, PMID:19428345 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO [esculetin co-treated with Paclitaxel] results in increased expression of FAS protein CTD PMID:16051289 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand multiple interactions ISO [esculetin co-treated with Paclitaxel] results in increased expression of FASLG protein CTD PMID:16051289 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO esculetin promotes the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of FASN mRNA] CTD PMID:27769711 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP esculetin inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]; esculetin inhibits the reaction [Streptozocin results in increased expression of FN1 protein] CTD PMID:21450970 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G G6pc glucose-6-phosphatase, catalytic subunit multiple interactions ISO esculetin promotes the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased activity of G6PC protein] CTD PMID:27769711 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Il6 interleukin 6 multiple interactions ISO esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL6 mRNA]; esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL6 protein] CTD PMID:27769711 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO
EXP
[esculetin co-treated with Paclitaxel] results in decreased expression of MAPK1 protein; esculetin results in decreased phosphorylation of and results in decreased activity of MAPK1 protein
esculetin results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [esculetin results in increased phosphorylation of MAPK1 protein]; SB 203580 inhibits the reaction [esculetin results in increased phosphorylation of MAPK1 protein]
CTD PMID:16051289, PMID:21600278, PMID:24995577 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO [esculetin co-treated with Paclitaxel] results in decreased expression of MAPK14 protein; esculetin results in decreased phosphorylation of and results in decreased activity of MAPK14 protein CTD PMID:16051289 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO
EXP
[esculetin co-treated with Paclitaxel] results in decreased expression of MAPK3 protein; esculetin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein
esculetin results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [esculetin results in increased phosphorylation of MAPK3 protein]; SB 203580 inhibits the reaction [esculetin results in increased phosphorylation of MAPK3 protein]
CTD PMID:16051289, PMID:21600278, PMID:24995577 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
increases expression
ISO [esculetin co-treated with Paclitaxel] results in increased expression of MAPK8 protein
esculetin results in increased phosphorylation of MAPK8 protein
esculetin results in increased expression of MAPK8 protein
CTD PMID:16051289, PMID:19786087 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases expression
ISO [esculetin co-treated with Paclitaxel] results in increased expression of MAPK9 protein
esculetin results in increased expression of MAPK9 protein
CTD PMID:16051289 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions EXP esculetin inhibits the reaction [Streptozocin results in increased expression of MMP13 mRNA] CTD PMID:21450970 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of MYD88 mRNA] CTD PMID:27769711 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases localization
affects localization
ISO esculetin results in increased localization of NFE2L2 protein
esculetin affects the localization of NFE2L2 protein
CTD PMID:20933534, PMID:30171828 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 affects localization ISO esculetin affects the localization of NFKB1 protein CTD PMID:30171828 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO esculetin promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:16212885 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NOS3 mRNA]; esculetin inhibits the reaction [Dietary Fats results in decreased expression of NOS3 mRNA] CTD PMID:28946194 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
ISO esculetin results in increased expression of and results in increased activity of NQO1 protein
esculetin results in increased expression of NQO1 mRNA
CTD PMID:20933534 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO esculetin results in increased cleavage of PARP1 protein CTD PMID:26388407, PMID:31313495 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP
ISO
esculetin inhibits the reaction [Streptozocin results in decreased expression of PPARG protein]; esculetin inhibits the reaction [Streptozocin results in increased expression of PPARG protein]
esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PPARG mRNA]
CTD PMID:21450970, PMID:27769711 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization ISO esculetin affects the localization of RELA protein CTD PMID:30171828 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sod1 superoxide dismutase 1 affects expression ISO esculetin affects the expression of SOD1 protein CTD PMID:30171828 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sp1 Sp1 transcription factor decreases expression ISO esculetin results in decreased expression of SP1 protein CTD PMID:31313495 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP esculetin inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein] CTD PMID:21450970 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TLR4 mRNA] CTD PMID:27769711 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TNF mRNA]; esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TNF protein] CTD PMID:27769711 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO esculetin results in increased expression of TNFRSF10A protein CTD PMID:19786087 NCBI chr15:51,433,853...51,464,215 JBrowse link
G Tp53 tumor protein p53 increases degradation
increases expression
ISO esculetin results in increased degradation of TP53 protein
esculetin results in increased expression of TP53 protein
CTD PMID:14634213, PMID:31313495 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of esculetin CTD PMID:7574722 NCBI chr14:22,375,428...22,486,291
Ensembl chr14:22,375,955...22,534,720
JBrowse link
G Usp16 ubiquitin specific peptidase 16 multiple interactions EXP esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of USP16 mRNA]; esculetin inhibits the reaction [Dietary Fats results in increased expression of USP16 mRNA] CTD PMID:28946194 NCBI chr11:27,101,213...27,130,345
Ensembl chr11:27,101,227...27,130,341
JBrowse link
G Usp22 ubiquitin specific peptidase 22 multiple interactions EXP esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of USP22 mRNA]; esculetin inhibits the reaction [Dietary Fats results in increased expression of USP22 mRNA] CTD PMID:28946194 NCBI chr10:47,429,201...47,453,298
Ensembl chr10:47,429,002...47,453,442
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of VCAM1 mRNA]; esculetin inhibits the reaction [Dietary Fats results in increased expression of VCAM1 mRNA] CTD PMID:28946194 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
N-phenylthiourea term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Car1 carbonic anhydrase 1 decreases activity ISO Phenylthiourea analog results in decreased activity of CA1 protein CTD PMID:30291660 NCBI chr 2:88,185,204...88,227,486
Ensembl chr 2:88,217,188...88,227,479
JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Phenylthiourea analog results in decreased activity of CA2 protein CTD PMID:30291660 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Casp9 caspase 9 increases expression ISO Phenylthiourea results in increased expression of CASP9 protein CTD PMID:16447258 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 increases response to substance ISO FMO3 protein results in increased susceptibility to Phenylthiourea CTD PMID:12093470 NCBI chr13:80,837,418...80,856,214
Ensembl chr13:80,837,420...80,862,963
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Phenylthiourea results in decreased expression of FOS protein CTD PMID:18003792 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Phenylthiourea results in increased phosphorylation of MAPK1 protein CTD PMID:26051519 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Phenylthiourea results in increased phosphorylation of MAPK3 protein CTD PMID:26051519 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mitf melanocyte inducing transcription factor increases expression ISO Phenylthiourea results in increased expression of MITF protein CTD PMID:26051519 NCBI chr 4:130,172,484...130,425,496
Ensembl chr 4:130,172,727...130,425,532
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO Phenylthiourea results in increased expression of PPARA protein CTD PMID:16447258 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression ISO Phenylthiourea results in increased expression of RELA protein CTD PMID:16447258 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tas2r138 taste receptor, type 2, member 138 affects response to substance
affects activity
increases activity
multiple interactions
ISO TAS2R38 gene polymorphism affects the susceptibility to Phenylthiourea
Phenylthiourea affects the activity of TAS2R38
Phenylthiourea results in increased activity of TAS2R38 protein
4-((diethylamino)sulfonyl)benzoic acid inhibits the reaction [Phenylthiourea results in increased activity of TAS2R38 protein]; Probenecid inhibits the reaction [Phenylthiourea results in increased activity of TAS2R38 protein]
CTD PMID:17684414, PMID:21629661, PMID:22384968 NCBI chr 4:68,831,221...68,832,216
Ensembl chr 4:68,831,221...68,832,216
JBrowse link
oxybenzone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acad10 acyl-CoA dehydrogenase family, member 10 increases expression EXP oxybenzone results in increased expression of ACAD10 mRNA CTD PMID:30316929 NCBI chr12:40,417,918...40,460,562
Ensembl chr12:40,417,944...40,460,561
JBrowse link
G Acad9 acyl-CoA dehydrogenase family, member 9 increases expression EXP oxybenzone results in increased expression of ACAD9 mRNA CTD PMID:30316929 NCBI chr 2:122,782,051...122,806,166
Ensembl chr 2:122,782,060...122,805,768
JBrowse link
G Acbd3 acyl-CoA binding domain containing 3 decreases expression EXP oxybenzone results in decreased expression of ACBD3 mRNA CTD PMID:30316929 NCBI chr13:99,004,942...99,035,520
Ensembl chr13:99,004,942...99,035,519
JBrowse link
G Aco2 aconitase 2 affects expression EXP oxybenzone affects the expression of ACO2 mRNA CTD PMID:30316929 NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635
JBrowse link
G Acot2 acyl-CoA thioesterase 2 increases expression EXP oxybenzone results in increased expression of ACOT2 mRNA CTD PMID:30316929 NCBI chr 6:107,460,596...107,468,324
Ensembl chr 6:107,460,668...107,467,487
JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression EXP oxybenzone results in increased expression of ACOX1 mRNA CTD PMID:30316929 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 decreases expression EXP oxybenzone results in decreased expression of ACSL5 mRNA CTD PMID:30316929 NCBI chr 1:276,240,703...276,290,012
Ensembl chr 1:276,240,703...276,290,008
JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 increases expression EXP oxybenzone results in increased expression of ACSS2 mRNA CTD PMID:30316929 NCBI chr 3:151,032,925...151,075,856
Ensembl chr 3:151,032,952...151,075,856
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ mRNA]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ protein] CTD PMID:32407875 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Adprhl1 ADP-ribosylhydrolase like 1 affects expression EXP oxybenzone affects the expression of ADPRHL1 mRNA CTD PMID:30316929 NCBI chr16:81,616,098...81,648,133
Ensembl chr16:81,616,604...81,632,030
JBrowse link
G Ahr aryl hydrocarbon receptor decreases expression
increases expression
EXP oxybenzone results in decreased expression of AHR mRNA
oxybenzone results in increased expression of AHR protein
CTD PMID:15458797, PMID:30099065 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Aif1 allograft inflammatory factor 1 increases expression EXP oxybenzone results in increased expression of AIF1 mRNA; oxybenzone results in increased expression of AIF1 protein CTD PMID:31368502 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G Apoc3 apolipoprotein C3 increases expression EXP oxybenzone results in increased expression of APOC3 mRNA CTD PMID:30316929 NCBI chr 8:50,529,318...50,531,498
Ensembl chr 8:50,529,318...50,531,498
JBrowse link
G Aqp1 aquaporin 1 decreases expression EXP oxybenzone results in decreased expression of AQP1 mRNA CTD PMID:30316929 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360
JBrowse link
G Ar androgen receptor multiple interactions
affects localization
ISO
EXP
oxybenzone binds to and results in decreased activity of AR protein; oxybenzone inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]
oxybenzone affects the localization of AR protein
CTD PMID:12730620, PMID:15537743, PMID:15950433, PMID:30099065 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Areg amphiregulin increases expression ISO oxybenzone results in increased expression of AREG mRNA CTD PMID:31939680 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha increases expression EXP oxybenzone results in increased expression of ATP5A1 mRNA CTD PMID:30316929 NCBI chr18:74,156,553...74,164,490
Ensembl chr18:74,156,553...74,164,495
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta increases expression EXP oxybenzone results in increased expression of ATP5B mRNA CTD PMID:30316929 NCBI chr 7:2,504,708...2,511,748
Ensembl chr 7:2,504,695...2,511,749
JBrowse link
G Atp5f1c ATP synthase F1 subunit gamma increases expression EXP oxybenzone results in increased expression of ATP5C1 mRNA CTD PMID:30316929 NCBI chr17:72,209,321...72,231,562
Ensembl chr17:72,209,373...72,394,271
JBrowse link
G Atp5mc2 ATP synthase membrane subunit c locus 2 decreases expression EXP oxybenzone results in decreased expression of ATP5G2 mRNA CTD PMID:30316929 NCBI chr 7:144,264,207...144,272,578
Ensembl chr 7:144,264,199...144,272,578
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression EXP oxybenzone results in increased expression of BAD mRNA CTD PMID:30316929 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression EXP oxybenzone results in increased expression of BAK1 mRNA; oxybenzone results in increased expression of BAK1 protein CTD PMID:30099065, PMID:30316929 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP oxybenzone results in increased expression of BAX mRNA; oxybenzone results in increased expression of BAX protein CTD PMID:30099065, PMID:30316929 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression EXP oxybenzone results in decreased expression of BCL2L1 mRNA CTD PMID:30316929 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcs1l BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone increases expression EXP oxybenzone results in increased expression of BCS1L mRNA CTD PMID:30316929 NCBI chr 9:81,868,158...81,872,201
Ensembl chr 9:81,868,265...81,872,197
JBrowse link
G Casp1 caspase 1 decreases expression EXP oxybenzone results in decreased expression of CASP1 mRNA CTD PMID:30316929 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp2 caspase 2 increases expression EXP oxybenzone results in increased expression of CASP2 mRNA CTD PMID:30316929 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
EXP oxybenzone results in increased activity of CASP3 protein
oxybenzone results in increased expression of and results in increased activity of CASP3 protein
CTD PMID:30099065, PMID:31368502 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp4 caspase 4 decreases expression EXP oxybenzone results in decreased expression of CASP4 mRNA CTD PMID:30316929 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
JBrowse link
G Casp9 caspase 9 increases activity
increases expression
EXP oxybenzone results in increased activity of CASP9 protein
oxybenzone results in increased expression of CASP9 mRNA
CTD PMID:30099065, PMID:30316929 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccl21 C-C motif chemokine ligand 21 decreases expression EXP oxybenzone results in decreased expression of CCL21 mRNA CTD PMID:30316929 NCBI chr 5:58,197,678...58,198,782
Ensembl chr 5:58,197,680...58,198,782
JBrowse link
G Cited4 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 increases expression EXP oxybenzone results in increased expression of CITED4 mRNA CTD PMID:30316929 NCBI chr 5:139,597,731...139,598,622
Ensembl chr 5:139,597,731...139,598,622
JBrowse link
G Cox15 cytochrome c oxidase assembly homolog COX15 increases expression EXP oxybenzone results in increased expression of COX15 mRNA CTD PMID:30316929 NCBI chr 1:263,494,850...263,511,510
Ensembl chr 1:263,494,852...263,511,505
JBrowse link
G Cox16 cytochrome c oxidase assembly factor COX16 decreases expression EXP oxybenzone results in decreased expression of COX16 mRNA CTD PMID:30316929 NCBI chr 6:105,195,387...105,214,366
Ensembl chr 6:105,201,395...105,214,329
JBrowse link
G Cox17 cytochrome c oxidase copper chaperone COX17 increases expression EXP oxybenzone results in increased expression of COX17 mRNA CTD PMID:30316929 NCBI chr11:64,962,663...64,968,437
Ensembl chr11:64,962,666...64,968,437
JBrowse link
G Cox18 cytochrome c oxidase assembly factor COX18 increases expression EXP oxybenzone results in increased expression of COX18 mRNA CTD PMID:30316929 NCBI chr14:19,434,728...19,446,379
Ensembl chr14:19,434,753...19,446,376
JBrowse link
G Cox5a cytochrome c oxidase subunit 5A increases expression EXP oxybenzone results in increased expression of COX5A mRNA CTD PMID:30316929 NCBI chr 8:62,298,358...62,309,765
Ensembl chr 8:62,298,358...62,309,765
JBrowse link
G Cox6b2 cytochrome c oxidase subunit 6B2 decreases expression EXP oxybenzone results in decreased expression of COX6B2 mRNA CTD PMID:30316929 NCBI chr 1:72,661,099...72,662,436
Ensembl chr 1:72,661,211...72,662,434
JBrowse link
G Cox7a2 cytochrome c oxidase subunit 7A2 decreases expression EXP oxybenzone results in decreased expression of COX7A2 mRNA CTD PMID:30316929 NCBI chr 8:87,209,529...87,213,627
Ensembl chr 8:87,209,530...87,213,627
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B increases expression EXP oxybenzone results in increased expression of CPT1B mRNA CTD PMID:30316929 NCBI chr 7:130,395,211...130,404,731
Ensembl chr 7:130,395,194...130,405,347
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 increases expression EXP oxybenzone results in increased expression of CPT2 mRNA CTD PMID:30316929 NCBI chr 5:127,505,646...127,523,016
Ensembl chr 5:127,505,614...127,523,089
JBrowse link
G Cpxm2 carboxypeptidase X (M14 family), member 2 decreases expression EXP oxybenzone results in decreased expression of CPXM2 mRNA CTD PMID:30316929 NCBI chr 1:204,048,785...204,161,090
Ensembl chr 1:204,048,785...204,087,001
JBrowse link
G Cstl1 cystatin-like 1 decreases expression EXP oxybenzone results in decreased expression of CSTL1 mRNA CTD PMID:30316929 NCBI chr 3:143,084,557...143,089,554
Ensembl chr 3:143,084,563...143,089,631
JBrowse link
G Cybrd1 cytochrome b reductase 1 increases expression EXP oxybenzone results in increased expression of CYBRD1 mRNA CTD PMID:30316929 NCBI chr 3:57,718,496...57,745,749
Ensembl chr 3:57,718,364...57,746,097
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression EXP oxybenzone results in increased expression of CYP19A1 mRNA CTD PMID:30599193 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 decreases expression EXP oxybenzone results in decreased expression of CYP21A1 mRNA CTD PMID:30316929 NCBI chr20:4,486,213...4,489,358
Ensembl chr20:4,486,219...4,489,550
JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 decreases expression EXP oxybenzone results in decreased expression of CYP24A1 mRNA CTD PMID:30316929 NCBI chr 3:168,097,484...168,111,920
Ensembl chr 3:168,097,485...168,111,920
JBrowse link
G Cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 increases expression EXP oxybenzone results in increased expression of CYP26C1 mRNA CTD PMID:30316929 NCBI chr 1:256,369,410...256,380,649
Ensembl chr 1:256,370,850...256,378,335
JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 increases expression EXP oxybenzone results in increased expression of CYP27B1 mRNA CTD PMID:30316929 NCBI chr 7:70,333,150...70,340,006
Ensembl chr 7:70,335,061...70,340,005
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases expression EXP oxybenzone results in decreased expression of CYP2B3 mRNA CTD PMID:30316929 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2d3 cytochrome P450, family 2, subfamily d, polypeptide 3 increases expression EXP oxybenzone results in increased expression of CYP2D3 mRNA CTD PMID:30316929 NCBI chr 7:123,634,400...123,638,757
Ensembl chr 7:123,625,590...123,638,765
JBrowse link
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 decreases expression EXP oxybenzone results in decreased expression of CYP4A3 mRNA CTD PMID:30316929 NCBI chr 5:134,468,666...134,484,851
Ensembl chr 5:134,469,270...134,484,839
JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 increases expression EXP oxybenzone results in increased expression of CYP4F18 mRNA CTD PMID:30316929 NCBI chr16:19,501,680...19,528,935
Ensembl chr16:19,410,810...19,528,999
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression EXP oxybenzone results in increased expression of CYP7A1 mRNA CTD PMID:30316929 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Dap death-associated protein decreases expression EXP oxybenzone results in decreased expression of DAP mRNA CTD PMID:30316929 NCBI chr 2:84,275,884...84,328,998
Ensembl chr 2:84,275,884...84,328,998
JBrowse link
G Dapk3 death-associated protein kinase 3 increases expression EXP oxybenzone results in increased expression of DAPK3 mRNA CTD PMID:30316929 NCBI chr 7:11,392,436...11,400,855
Ensembl chr 7:11,392,437...11,400,805
JBrowse link
G Daxx death-domain associated protein increases expression EXP oxybenzone results in increased expression of DAXX mRNA CTD PMID:30316929 NCBI chr20:5,480,103...5,485,962
Ensembl chr20:5,480,103...5,485,926
JBrowse link
G Dedd death effector domain-containing increases expression EXP oxybenzone results in increased expression of DEDD mRNA CTD PMID:30316929 NCBI chr13:89,706,932...89,721,825
Ensembl chr13:89,718,066...89,721,454
JBrowse link
G Dffa DNA fragmentation factor subunit alpha increases expression EXP oxybenzone results in increased expression of DFFA mRNA CTD PMID:30316929 NCBI chr 5:165,922,893...165,935,822
Ensembl chr 5:165,922,915...165,935,821
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) increases expression EXP oxybenzone results in increased expression of DHODH mRNA CTD PMID:30316929 NCBI chr19:42,066,103...42,087,906
Ensembl chr19:42,066,351...42,082,012
JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase increases expression EXP oxybenzone results in increased expression of DLST mRNA CTD PMID:30316929 NCBI chr 6:108,936,534...108,961,322
Ensembl chr 6:108,936,664...108,959,803
JBrowse link
G Dlx3 distal-less homeobox 3 affects expression EXP oxybenzone affects the expression of DLX3 mRNA CTD PMID:30316929 NCBI chr10:82,937,971...82,943,367
Ensembl chr10:82,937,971...82,943,348
JBrowse link
G Dnajc15 DnaJ heat shock protein family (Hsp40) member C15 decreases expression EXP oxybenzone results in decreased expression of DNAJC15 mRNA CTD PMID:30316929 NCBI chr15:59,990,131...60,056,710
Ensembl chr15:59,990,131...60,056,710
JBrowse link
G Echs1 enoyl-CoA hydratase, short chain 1 increases expression EXP oxybenzone results in increased expression of ECHS1 mRNA CTD PMID:30316929 NCBI chr 1:212,570,213...212,579,040
Ensembl chr 1:212,570,195...212,579,057
JBrowse link
G Esr1 estrogen receptor 1 decreases expression
increases expression
multiple interactions
EXP
ISO
oxybenzone results in decreased expression of ESR1 mRNA; oxybenzone results in decreased expression of ESR1 protein
oxybenzone results in increased expression of ESR1 mRNA
oxybenzone binds to and results in increased activity of ESR1 protein
CTD PMID:15458797, PMID:16079615, PMID:30099065 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects expression
decreases expression
ISO
EXP
oxybenzone binds to and results in increased activity of ESR2 protein
oxybenzone affects the expression of ESR2 protein
oxybenzone results in decreased expression of ESR2 mRNA
CTD PMID:16079615, PMID:30099065 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Esrra estrogen related receptor, alpha decreases expression EXP oxybenzone results in decreased expression of ESRRA mRNA CTD PMID:15458797 NCBI chr 1:222,168,729...222,178,842
Ensembl chr 1:222,168,730...222,178,725
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA] CTD PMID:32407875 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fam180a family with sequence similarity 180, member A decreases expression EXP oxybenzone results in decreased expression of FAM180A mRNA CTD PMID:30316929 NCBI chr 4:62,845,054...62,860,361
Ensembl chr 4:62,844,971...62,860,446
JBrowse link
G Fam71b family with sequence similarity 71, member B decreases expression EXP oxybenzone results in decreased expression of FAM71B mRNA CTD PMID:30316929 NCBI chr10:31,508,549...31,511,787
Ensembl chr10:31,508,512...31,511,788
JBrowse link
G Fam71f2 family with sequence similarity 71, member F2 decreases expression EXP oxybenzone results in decreased expression of FAM71F2 mRNA CTD PMID:30316929 NCBI chr 4:56,556,545...56,567,350
Ensembl chr 4:56,556,507...56,567,346
JBrowse link
G Flg filaggrin affects response to substance
multiple interactions
ISO FLG gene mutant form affects the susceptibility to oxybenzone
[FLG gene mutant form affects the susceptibility to oxybenzone] which results in decreased secretion of FSHB protein; [FLG gene mutant form affects the susceptibility to oxybenzone] which results in increased secretion of Estradiol; [FLG gene mutant form affects the susceptibility to oxybenzone] which results in increased secretion of Testosterone
CTD PMID:30245359 NCBI chr 2:193,565,401...193,574,297 JBrowse link
G Foxl2 forkhead box L2 increases expression
multiple interactions
EXP oxybenzone results in increased expression of FOXL2 mRNA
4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol inhibits the reaction [oxybenzone results in increased expression of FOXL2 mRNA]
CTD PMID:30599193 NCBI chr 8:107,194,492...107,197,644
Ensembl chr 8:107,194,551...107,195,675
JBrowse link
G Frzb frizzled-related protein decreases expression EXP oxybenzone results in decreased expression of FRZB mRNA CTD PMID:30316929 NCBI chr 3:67,635,604...67,668,772
Ensembl chr 3:67,635,607...67,668,772
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO [FLG gene mutant form affects the susceptibility to oxybenzone] which results in decreased secretion of FSHB protein CTD PMID:30245359 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Fst follistatin increases expression EXP oxybenzone results in increased expression of FST mRNA CTD PMID:30599193 NCBI chr 2:46,537,589...46,544,813
Ensembl chr 2:46,538,700...46,544,457
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 affects expression EXP oxybenzone affects the expression of GPER1 protein CTD PMID:30099065 NCBI chr12:17,309,122...17,315,267
Ensembl chr12:17,309,834...17,311,112
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 affects expression EXP oxybenzone affects the expression of GRIN1 protein CTD PMID:31368502 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A affects expression EXP oxybenzone affects the expression of GRIN2A protein CTD PMID:31368502 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 decreases expression EXP oxybenzone results in decreased expression of GSTA2 mRNA CTD PMID:30316929 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta5 glutathione S-transferase alpha 5 decreases expression EXP oxybenzone results in decreased expression of GSTA5 mRNA CTD PMID:30316929 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression EXP oxybenzone results in increased expression of GSTM1 mRNA CTD PMID:30316929 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP oxybenzone results in increased expression of GSTP1 mRNA CTD PMID:30316929 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gstt2 glutathione S-transferase, theta 2 increases expression EXP oxybenzone results in increased expression of GSTT2 mRNA CTD PMID:30316929 NCBI chr20:13,760,810...13,764,481
Ensembl chr20:13,760,810...13,764,475
JBrowse link
G Gstt4 glutathione S-transferase, theta 4 decreases expression EXP oxybenzone results in decreased expression of GSTT4 mRNA CTD PMID:30316929 NCBI chr20:13,778,185...13,784,813
Ensembl chr20:13,778,178...13,784,827
JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions
ISO oxybenzone results in increased expression of H2AX protein modified form
Fulvestrant inhibits the reaction [oxybenzone results in increased expression of H2AX protein modified form]
CTD PMID:31939680 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha decreases expression EXP oxybenzone results in decreased expression of HADHA mRNA CTD PMID:30316929 NCBI chr 6:27,589,840...27,628,921
Ensembl chr 6:27,589,657...27,629,175
JBrowse link
G Hdac1 histone deacetylase 1 increases expression EXP oxybenzone results in increased expression of HDAC1 protein CTD PMID:31368502 NCBI chr 5:147,716,664...147,743,723
Ensembl chr 5:147,716,664...147,743,723
JBrowse link
G Hdac2 histone deacetylase 2 increases expression EXP oxybenzone results in increased expression of HDAC2 protein CTD PMID:31368502 NCBI chr20:43,084,870...43,108,198
Ensembl chr20:43,084,870...43,108,198
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO oxybenzone results in increased expression of HMGCR mRNA CTD PMID:32407875 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO oxybenzone results in increased expression of HMGCS1 mRNA CTD PMID:32407875 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression EXP oxybenzone results in decreased expression of HMGCS2 mRNA CTD PMID:30316929 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 decreases expression EXP oxybenzone results in decreased expression of HSD17B10 mRNA CTD PMID:30316929 NCBI chr  X:21,696,796...21,699,241
Ensembl chr  X:21,696,772...21,699,241
JBrowse link
G Hsdl2 hydroxysteroid dehydrogenase like 2 decreases expression EXP oxybenzone results in decreased expression of HSDL2 mRNA CTD PMID:30316929 NCBI chr 5:76,812,881...76,848,853
Ensembl chr 5:76,812,931...76,848,101
JBrowse link
G Hykk hydroxylysine kinase increases expression EXP oxybenzone results in increased expression of HYKK mRNA CTD PMID:30316929 NCBI chr 8:59,507,975...59,531,745
Ensembl chr 8:59,507,990...59,529,366
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 decreases expression EXP oxybenzone results in decreased expression of IDH2 mRNA CTD PMID:30316929 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
JBrowse link
G Idh3g isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma increases expression EXP oxybenzone results in increased expression of IDH3G mRNA CTD PMID:30316929 NCBI chr  X:156,999,803...157,008,735
Ensembl chr  X:156,999,826...157,008,733
JBrowse link
G Il19 interleukin 19 increases expression EXP oxybenzone results in increased expression of IL19 mRNA CTD PMID:30316929 NCBI chr13:47,663,592...47,677,869
Ensembl chr13:47,664,080...47,670,407
JBrowse link
G Ins2 insulin 2 multiple interactions ISO oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ mRNA]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ protein]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA] CTD PMID:32407875 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Iqcf6 IQ motif containing F6 decreases expression EXP oxybenzone results in decreased expression of IQCF6 mRNA CTD PMID:30316929 NCBI chr 8:115,328,535...115,329,546
Ensembl chr 8:115,328,535...115,329,546
JBrowse link
G Krt18 keratin 18 decreases expression EXP oxybenzone results in decreased expression of KRT18 mRNA CTD PMID:30316929 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G LOC100911804 apolipoprotein L3-like increases expression EXP oxybenzone results in increased expression of APOL2 mRNA CTD PMID:30316929 NCBI chr 7:118,979,230...118,986,699
Ensembl chr 7:118,979,608...118,983,984
JBrowse link
G Lsmem1 leucine-rich single-pass membrane protein 1 increases expression EXP oxybenzone results in increased expression of LSMEM1 mRNA CTD PMID:30316929 NCBI chr 6:60,114,077...60,124,297
Ensembl chr 6:60,114,103...60,124,274
JBrowse link
G Magel2 MAGE family member L2 increases expression EXP oxybenzone results in increased expression of MAGEL2 mRNA CTD PMID:30316929 NCBI chr 1:123,015,404...123,019,945
Ensembl chr 1:123,015,746...123,019,522
JBrowse link
G Mcc MCC regulator of WNT signaling pathway decreases expression EXP oxybenzone results in decreased expression of MCC mRNA CTD PMID:30316929 NCBI chr18:35,683,185...35,817,117
NCBI chr 1:12,006,663...12,128,849
Ensembl chr 1:12,006,660...12,128,845
Ensembl chr18:12,006,660...12,128,845
JBrowse link
G Medag mesenteric estrogen-dependent adipogenesis decreases expression EXP oxybenzone results in decreased expression of MEDAG mRNA CTD PMID:30316929 NCBI chr12:6,711,745...6,730,959
Ensembl chr12:6,711,747...6,740,714
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO oxybenzone promotes the reaction [NCOA2 protein binds to PPARG protein] CTD PMID:32407875 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Ndufa11 NADH:ubiquinone oxidoreductase subunit A11 decreases expression EXP oxybenzone results in decreased expression of NDUFA11 mRNA CTD PMID:30316929 NCBI chr 9:10,334,104...10,338,163
Ensembl chr 9:10,334,090...10,338,216
JBrowse link
G Ndufa3 NADH:ubiquinone oxidoreductase subunit A3 decreases expression EXP oxybenzone results in decreased expression of NDUFA3 mRNA CTD PMID:30316929 NCBI chr 1:64,172,462...64,175,174
Ensembl chr 1:64,172,540...64,175,099
JBrowse link
G Ndufa9 NADH:ubiquinone oxidoreductase subunit A9 increases expression EXP oxybenzone results in increased expression of NDUFA9 mRNA CTD PMID:30316929 NCBI chr 4:159,371,263...159,399,636
Ensembl chr 4:159,371,259...159,399,634
JBrowse link
G Ndufab1 NADH:ubiquinone oxidoreductase subunit AB1 increases expression EXP oxybenzone results in increased expression of NDUFAB1 mRNA CTD PMID:30316929 NCBI chr 1:192,044,209...192,057,644
Ensembl chr 1:192,044,216...192,057,612
JBrowse link
G Ndufb10 NADH:ubiquinone oxidoreductase subunit B10 increases expression EXP oxybenzone results in increased expression of NDUFB10 mRNA CTD PMID:30316929 NCBI chr10:14,090,128...14,092,289
Ensembl chr10:14,090,128...14,092,289
JBrowse link
G Ndufb7 NADH:ubiquinone oxidoreductase subunit B7 increases expression EXP oxybenzone results in increased expression of NDUFB7 mRNA CTD PMID:30316929 NCBI chr19:24,701,067...24,705,405
Ensembl chr19:24,701,049...24,705,405
JBrowse link
G Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 decreases expression EXP oxybenzone results in decreased expression of NDUFS2 mRNA CTD PMID:30316929 NCBI chr13:89,606,848...89,623,506
Ensembl chr13:89,606,840...89,619,398
JBrowse link
G Ndufv3 NADH:ubiquinone oxidoreductase subunit V3 affects expression EXP oxybenzone affects the expression of NDUFV3 mRNA CTD PMID:30316929 NCBI chr20:10,265,826...10,275,298
Ensembl chr20:10,265,806...10,275,304
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO oxybenzone results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Nrf1 nuclear respiratory factor 1 increases expression EXP oxybenzone results in increased expression of NRF1 mRNA CTD PMID:30316929 NCBI chr 4:57,335,732...57,445,317
Ensembl chr 4:57,378,069...57,445,341
JBrowse link
G Ntn5 netrin 5 increases expression EXP oxybenzone results in increased expression of NTN5 mRNA CTD PMID:30316929 NCBI chr 1:101,668,354...101,678,117
Ensembl chr 1:101,669,086...101,677,596
JBrowse link
G Ogdh oxoglutarate dehydrogenase increases expression
decreases expression
EXP oxybenzone results in increased expression of OGDH mRNA
oxybenzone results in decreased expression of OGDH mRNA
CTD PMID:30316929 NCBI chr14:86,414,924...86,481,903
Ensembl chr14:86,414,949...86,613,327
JBrowse link
G Olr97 olfactory receptor 97 increases expression EXP oxybenzone results in increased expression of OLR97 mRNA CTD PMID:30316929 NCBI chr 1:168,500,223...168,502,357
Ensembl chr 1:168,500,304...168,501,212
JBrowse link
G Pdcd11 programmed cell death 11 increases expression EXP oxybenzone results in increased expression of PDCD11 mRNA CTD PMID:30316929 NCBI chr 1:266,866,931...266,908,042
Ensembl chr 1:266,866,931...266,908,042
JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein decreases expression EXP oxybenzone results in decreased expression of PDCD6IP mRNA CTD PMID:30316929 NCBI chr 8:121,916,233...121,973,145
Ensembl chr 8:121,916,185...121,973,125
JBrowse link
G Pdcd7 programmed cell death 7 increases expression EXP oxybenzone results in increased expression of PDCD7 mRNA CTD PMID:30316929 NCBI chr 8:70,860,671...70,875,471
Ensembl chr 8:70,860,671...70,875,471
JBrowse link
G Pgr progesterone receptor multiple interactions
increases expression
ISO oxybenzone binds to and results in decreased activity of PGR protein
oxybenzone results in increased expression of PGR mRNA
CTD PMID:15537743, PMID:31939680 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Phf24 PHD finger protein 24 increases expression EXP oxybenzone results in increased expression of PHF24 mRNA CTD PMID:30316929 NCBI chr 5:58,359,744...58,387,446
Ensembl chr 5:58,359,498...58,383,070
JBrowse link
G Polm DNA polymerase mu decreases expression EXP oxybenzone results in decreased expression of POLM mRNA CTD PMID:30316929 NCBI chr14:86,069,378...86,079,327
Ensembl chr14:86,069,016...86,078,954
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO oxybenzone results in increased expression of PPARA mRNA CTD PMID:32407875 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects binding
multiple interactions
increases expression
ISO oxybenzone binds to PPARG protein
oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA]; oxybenzone promotes the reaction [NCOA2 protein binds to PPARG protein]
oxybenzone results in increased expression of PPARG mRNA
CTD PMID:32407875 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Prss37 serine protease 37 decreases expression EXP oxybenzone results in decreased expression of PRSS37 mRNA CTD PMID:30316929 NCBI chr 4:68,337,498...68,349,286
Ensembl chr 4:68,337,480...68,349,273
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression EXP oxybenzone results in increased expression of RELA protein CTD PMID:31368502 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Retn resistin decreases expression EXP oxybenzone results in decreased expression of RETN mRNA CTD PMID:30316929 NCBI chr12:2,201,909...2,203,649
Ensembl chr12:2,201,891...2,204,249
JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A increases expression EXP oxybenzone results in increased expression of SDHA mRNA CTD PMID:30316929 NCBI chr 1:31,545,631...31,570,601
Ensembl chr 1:31,545,631...31,570,601
JBrowse link
G Serpinc1 serpin family C member 1 increases expression EXP oxybenzone results in increased expression of SERPINC1 mRNA CTD PMID:30316929 NCBI chr13:78,806,107...78,820,375
Ensembl chr13:78,805,347...78,833,192
JBrowse link
G Sh3glb1 SH3 domain -containing GRB2-like endophilin B1 increases expression EXP oxybenzone results in increased expression of SH3GLB1 mRNA CTD PMID:30316929 NCBI chr 2:250,709,812...250,744,216
Ensembl chr 2:250,709,439...250,744,196
JBrowse link
G Shank1 SH3 and multiple ankyrin repeat domains 1 increases expression EXP oxybenzone results in increased expression of SHANK1 mRNA CTD PMID:30316929 NCBI chr 1:100,297,137...100,344,377
Ensembl chr 1:100,297,152...100,344,377
JBrowse link
G Slc1a2 solute carrier family 1 member 2 affects expression EXP oxybenzone affects the expression of SLC1A2 protein CTD PMID:31368502 NCBI chr 3:92,518,679...92,665,731
Ensembl chr 3:92,640,752...92,665,644
JBrowse link
G Slc7a11 solute carrier family 7 member 11 affects expression EXP oxybenzone affects the expression of SLC7A11 protein CTD PMID:31368502 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Sox9 SRY-box transcription factor 9 multiple interactions
increases expression
EXP 4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol inhibits the reaction [oxybenzone results in increased expression of SOX9 mRNA] CTD PMID:30599193 NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379
JBrowse link
G Sstr3 somatostatin receptor 3 increases expression EXP oxybenzone results in increased expression of SSTR3 mRNA CTD PMID:30316929 NCBI chr 7:119,760,881...119,768,082
Ensembl chr 7:119,760,888...119,768,082
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases expression EXP oxybenzone results in decreased expression of SULT1A1 mRNA CTD PMID:30316929 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Tex46 testis expressed 46 decreases expression EXP oxybenzone results in decreased expression of TEX46 mRNA CTD PMID:30316929 NCBI chr 5:154,976,211...154,980,671
Ensembl chr 5:154,976,165...154,980,712
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression EXP oxybenzone results in increased expression of TFAM mRNA CTD PMID:30316929 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151
JBrowse link
G Tff1 trefoil factor 1 multiple interactions
increases expression
ISO [oxybenzone co-treated with 2,4-dihydroxybenzophenone co-treated with octylmethoxycinnamate co-treated with enzacamene] results in increased expression of TFF1 mRNA; [oxybenzone co-treated with 2,4-dihydroxybenzophenone] results in increased expression of TFF1 mRNA
oxybenzone results in increased expression of TFF1 mRNA
CTD PMID:16183391 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
G Tmprss4 transmembrane serine protease 4 increases expression EXP oxybenzone results in increased expression of TMPRSS4 mRNA CTD PMID:30316929 NCBI chr 8:49,469,804...49,503,304
Ensembl chr 8:49,469,503...49,502,647
JBrowse link
G Tp53 tumor protein p53 decreases expression EXP oxybenzone results in decreased expression of TP53 mRNA CTD PMID:30316929 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 increases expression ISO oxybenzone results in increased expression of TP53BP1 protein CTD PMID:31939680 NCBI chr 3:113,160,030...113,259,701
Ensembl chr 3:113,160,000...113,231,790
JBrowse link
G Tspo translocator protein decreases expression EXP oxybenzone results in decreased expression of TSPO mRNA CTD PMID:30316929 NCBI chr 7:124,460,358...124,470,610
Ensembl chr 7:124,460,358...124,470,609
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 decreases expression EXP oxybenzone results in decreased expression of UGT1A6 mRNA CTD PMID:30316929 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2a3 UDP glucuronosyltransferase family 2 member A3 decreases expression EXP oxybenzone results in decreased expression of UGT2A3 mRNA CTD PMID:30316929 NCBI chr14:22,251,507...22,267,899
Ensembl chr14:22,192,970...22,619,968
JBrowse link
G Upk1b uroplakin 1B decreases expression EXP oxybenzone results in decreased expression of UPK1B mRNA CTD PMID:30316929 NCBI chr11:64,522,008...64,553,234
Ensembl chr11:64,522,130...64,553,228
JBrowse link
G Uqcr11 ubiquinol-cytochrome c reductase, complex III subunit XI affects expression EXP oxybenzone affects the expression of UQCR11 mRNA CTD PMID:30316929 NCBI chr 7:12,171,146...12,175,838
Ensembl chr 7:12,171,185...12,175,835
JBrowse link
G Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 increases expression EXP oxybenzone results in increased expression of UQCRC1 mRNA CTD PMID:30316929 NCBI chr 8:117,679,328...117,691,073
Ensembl chr 8:117,679,278...117,691,071
JBrowse link
G Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 decreases expression EXP oxybenzone results in decreased expression of UQCRFS1 mRNA CTD PMID:30316929 NCBI chr17:35,677,984...35,682,262
Ensembl chr17:35,677,984...35,682,259
JBrowse link
G Uqcrq ubiquinol-cytochrome c reductase, complex III subunit VII increases expression EXP oxybenzone results in increased expression of UQCRQ mRNA CTD PMID:30316929 NCBI chr10:38,779,132...38,782,489
Ensembl chr10:38,779,132...38,782,419
JBrowse link
G V1ra14 vomeronasal 1 receptor A14 increases expression EXP oxybenzone results in increased expression of V1RA14 mRNA CTD PMID:30316929
G Vdac1 voltage-dependent anion channel 1 decreases expression EXP oxybenzone results in decreased expression of VDAC1 mRNA CTD PMID:30316929 NCBI chr10:37,724,915...37,752,827
Ensembl chr10:37,724,915...37,752,826
JBrowse link
phenyl salicylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 increases activity
multiple interactions
ISO phenyl salicylate results in increased activity of ESR1 protein
phenyl salicylate binds to and results in increased activity of ESR1 protein
CTD PMID:22197706, PMID:24004914 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
thiourea term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein increases uptake ISO Thiourea results in increased uptake of APP protein modified form CTD PMID:20637185 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Aqp1 aquaporin 1 decreases expression EXP Thiourea results in decreased expression of AQP1 mRNA CTD PMID:15248066 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) increases expression EXP Thiourea results in increased expression of AQP3 mRNA CTD PMID:15248066 NCBI chr 5:57,423,735...57,429,252
Ensembl chr 5:57,423,734...57,429,245
JBrowse link
G Aqp4 aquaporin 4 decreases expression EXP Thiourea results in decreased expression of AQP4 mRNA CTD PMID:15248066 NCBI chr18:6,766,009...6,782,757
Ensembl chr18:6,765,945...6,782,996
JBrowse link
G Aqp5 aquaporin 5 decreases expression EXP Thiourea results in decreased expression of AQP5 mRNA CTD PMID:15248066 NCBI chr 7:141,249,044...141,252,576
Ensembl chr 7:141,249,044...141,252,578
JBrowse link
G Aqp9 aquaporin 9 increases uptake EXP AQP9 protein results in increased uptake of Thiourea CTD PMID:9733774 NCBI chr 8:77,559,621...77,599,781
Ensembl chr 8:77,559,624...77,599,781
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Thiourea inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of BAX protein] CTD PMID:29803612 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO Thiourea analog results in decreased activity of CA1 protein CTD PMID:28117934 NCBI chr 2:88,185,204...88,227,486
Ensembl chr 2:88,217,188...88,227,479
JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Thiourea analog results in decreased activity of CA2 protein CTD PMID:28117934 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
Thiourea analog inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]
Thiourea inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased activity of CASP3 protein]
CTD PMID:14599462, PMID:29803612 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cftr CF transmembrane conductance regulator decreases expression EXP Thiourea results in decreased expression of CFTR mRNA CTD PMID:15248066 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 increases metabolic processing ISO FMO2 protein results in increased metabolism of Thiourea CTD PMID:12214664 NCBI chr13:80,752,526...80,775,264
Ensembl chr13:80,755,058...80,775,264
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 multiple interactions
increases response to substance
ISO Buthionine Sulfoximine inhibits the reaction [FMO3 protein results in increased susceptibility to Thiourea] CTD PMID:12093470 NCBI chr13:80,837,418...80,856,214
Ensembl chr13:80,837,420...80,862,963
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Thiourea inhibits the reaction [tert-Butylhydroperoxide results in increased expression of FOS mRNA] CTD PMID:15105052 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP Thiourea inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR mRNA]; Thiourea inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR protein] CTD PMID:19931295 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Ifng interferon gamma multiple interactions ISO Thiourea analog inhibits the reaction [IFNG protein promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of SPP1 mRNA]] CTD PMID:10868913 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Thiourea inhibits the reaction [cadmium acetate results in increased secretion of IL6 protein]; Thiourea inhibits the reaction [Particulate Matter results in increased expression of IL6 mRNA]; Thiourea inhibits the reaction [sodium arsenite results in increased secretion of IL6 protein]; Thiourea inhibits the reaction [Vehicle Emissions results in increased expression of IL6 mRNA]; Thiourea inhibits the reaction [zinc chloride results in increased secretion of IL6 protein] CTD PMID:26160521, PMID:27427241 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Thiourea inhibits the reaction [tert-Butylhydroperoxide results in increased expression of JUN mRNA] CTD PMID:15105052 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions
ISO Thiourea analog results in decreased expression of NOS2 mRNA; Thiourea analog results in decreased expression of NOS2 protein; Thiourea results in decreased expression of NOS2 protein
[Thiourea analog results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; Thiourea results in decreased susceptibility to [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD PMID:17467989, PMID:20637185 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
ISO Thiourea results in decreased expression of PTGS2 protein
Thiourea results in decreased susceptibility to [Lipopolysaccharides results in increased expression of PTGS2 protein]
CTD PMID:20637185 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha decreases expression EXP Thiourea results in decreased expression of SCNN1A mRNA CTD PMID:15248066 NCBI chr 4:157,834,339...157,860,472
Ensembl chr 4:157,836,912...157,860,049
JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta decreases expression EXP Thiourea results in decreased expression of SCNN1B mRNA CTD PMID:15248066 NCBI chr 1:191,829,547...191,883,991
Ensembl chr 1:191,829,555...191,884,298
JBrowse link
G Scnn1g sodium channel epithelial 1 subunit gamma decreases expression EXP Thiourea results in decreased expression of SCNN1G mRNA CTD PMID:15248066 NCBI chr 1:191,704,397...191,738,271
Ensembl chr 1:191,704,311...191,738,268
JBrowse link
G Slc14a1 solute carrier family 14 member 1 (Kidd blood group) multiple interactions ISO Thiourea inhibits the reaction [SLC14A1 protein affects the transport of Urea] CTD PMID:17506977 NCBI chr18:74,461,064...74,504,475
Ensembl chr18:74,461,055...74,485,139
JBrowse link
G Slc14a2 solute carrier family 14 member 2 multiple interactions EXP Thiourea analog inhibits the reaction [SLC14A2 protein results in increased transport of Urea] CTD PMID:11181411 NCBI chr18:74,508,070...74,941,389
Ensembl chr18:74,546,220...74,688,551
Ensembl chr18:74,546,220...74,688,551
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO Thiourea analog inhibits the reaction [IFNG protein promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of SPP1 mRNA]] CTD PMID:10868913 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Thiourea inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of TP53 protein] CTD PMID:29803612 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
trans-urocanic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flg filaggrin decreases abundance ISO FLG mutant form results in decreased abundance of Urocanic Acid CTD PMID:24061166 NCBI chr 2:193,565,401...193,574,297 JBrowse link
G Ifng interferon gamma multiple interactions ISO IFNG protein affects the susceptibility to [Permethrin co-treated with Urocanic Acid] CTD PMID:14617103 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Tnf tumor necrosis factor affects response to substance ISO TNF protein affects the susceptibility to Urocanic Acid CTD PMID:14617103 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
urocanic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flg filaggrin decreases abundance ISO FLG mutant form results in decreased abundance of Urocanic Acid CTD PMID:24061166 NCBI chr 2:193,565,401...193,574,297 JBrowse link
G Ifng interferon gamma multiple interactions ISO IFNG protein affects the susceptibility to [Permethrin co-treated with Urocanic Acid] CTD PMID:14617103 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Tnf tumor necrosis factor affects response to substance ISO TNF protein affects the susceptibility to Urocanic Acid CTD PMID:14617103 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

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  CHEBI ontology 19785
    role 19732
      chemical role 19248
        photochemical role 232
          chromophore + 52
          lumiphore 0
          photobiochemical role + 0
          ultraviolet filter + 201
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.