CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: beta-substituted porphyrin
Accession: CHEBI:52187
browse the term
Definition: A porphyrin compound which is substituted via the pyrrole groups in the porphyrin ring.
Synonyms: related_synonym: beta-substituted porphyrins
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Ankrd1
ankyrin repeat domain 1
multiple interactions decreases expression
ISO
verteporfin inhibits the reaction [YAP1 protein results in increased expression of ANKRD1 mRNA] Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ANKRD1 mRNA] verteporfin results in decreased expression of ANKRD1 mRNA
CTD
PMID:29725256 PMID:29893953
NCBI chr 1:254,726,985...254,745,673
Ensembl chr 1:254,726,969...254,735,548
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Birc5
baculoviral IAP repeat-containing 5
multiple interactions
ISO
Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of BIRC5 mRNA]
CTD
PMID:29893953
NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
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Ccl2
C-C motif chemokine ligand 2
multiple interactions
ISO
Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL2 protein]
CTD
PMID:31812773
NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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Ccl5
C-C motif chemokine ligand 5
multiple interactions
ISO
Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL5 protein]
CTD
PMID:31812773
NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
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Ccn1
cellular communication network factor 1
multiple interactions decreases expression
ISO
Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN1 mRNA] Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CCN1 mRNA] Verteporfin results in decreased expression of CCN1 mRNA
CTD
PMID:29725256 PMID:29893953
NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312
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Ccn2
cellular communication network factor 2
decreases expression multiple interactions
ISO
Verteporfin results in decreased expression of CCN2 mRNA Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN2 mRNA]
CTD
PMID:29725256
NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
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Ccna2
cyclin A2
multiple interactions
ISO
Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CCNA2 mRNA]
CTD
PMID:29893953
NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
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Ccnb1
cyclin B1
multiple interactions
ISO
Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CCNB1 mRNA]
CTD
PMID:29893953
NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
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Cma1
chymase 1
multiple interactions
ISO
Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CMA1 protein]
CTD
PMID:31812773
NCBI chr15:34,601,037...34,603,819
Ensembl chr15:34,601,037...34,603,819
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Csf3
colony stimulating factor 3
multiple interactions
ISO
Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CSF3 protein]
CTD
PMID:31812773
NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157
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Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
multiple interactions
ISO
Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CYP2B10 mRNA]
CTD
PMID:29893953
NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
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Cyp2c24
cytochrome P450, family 2, subfamily c, polypeptide 24
multiple interactions
ISO
Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CYP2C55 mRNA]
CTD
PMID:29893953
NCBI chr 1:258,074,797...258,139,176
Ensembl chr 1:258,074,860...258,139,176
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Hmox1
heme oxygenase 1
increases expression
ISO
verteporfin results in increased expression of HMOX1 protein
CTD
PMID:16462769
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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Il6
interleukin 6
multiple interactions
ISO
[EVP 4593 co-treated with Verteporfin] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA] Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]
CTD
PMID:31812773
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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Jak1
Janus kinase 1
multiple interactions decreases expression
ISO
[Verteporfin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased expression of JAK1 protein Verteporfin results in decreased expression of JAK1 protein
CTD
PMID:31812773
NCBI chr 5:119,982,503...120,091,452
Ensembl chr 5:119,982,943...120,083,904
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Jak2
Janus kinase 2
decreases expression multiple interactions
ISO
Verteporfin results in decreased expression of JAK2 protein [Verteporfin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased expression of JAK2 protein
CTD
PMID:31812773
NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
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Mcm2
minichromosome maintenance complex component 2
multiple interactions
ISO
Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of MCM2 mRNA]
CTD
PMID:29893953
NCBI chr 4:120,825,699...120,840,221
Ensembl chr 4:120,825,699...120,840,111
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Parp1
poly (ADP-ribose) polymerase 1
increases cleavage
ISO
Verteporfin results in increased cleavage of PARP1 protein
CTD
PMID:31494105
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
[Verteporfin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased expression of RELA protein; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of and results in increased phosphorylation of RELA protein]
CTD
PMID:31812773
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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Stat1
signal transducer and activator of transcription 1
decreases expression multiple interactions
ISO
Verteporfin results in decreased expression of STAT1 protein Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of and results in increased phosphorylation of STAT1 protein]
CTD
PMID:31812773
NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
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Stat3
signal transducer and activator of transcription 3
multiple interactions decreases expression
ISO
Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of and results in increased phosphorylation of STAT3 protein] Verteporfin results in decreased expression of STAT3 protein
CTD
PMID:31812773
NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
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Tead1
TEA domain transcription factor 1
multiple interactions
ISO
Verteporfin inhibits the reaction [YAP1 protein binds to TEAD1 protein]
CTD
PMID:29893953
NCBI chr 1:177,495,500...177,714,795
Ensembl chr 1:177,495,782...177,707,061
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Tnf
tumor necrosis factor
multiple interactions
ISO
Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein] [EVP 4593 co-treated with Verteporfin] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]
CTD
PMID:31812773
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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Yap1
Yes1 associated transcriptional regulator
multiple interactions decreases expression
ISO
Verteporfin inhibits the reaction [YAP1 protein results in increased expression of ANKRD1 mRNA]; Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN1 mRNA]; Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN2 mRNA] Verteporfin results in decreased expression of YAP1 protein Verteporfin inhibits the reaction [YAP1 protein binds to TEAD1 protein]
CTD
PMID:29725256 PMID:29893953 PMID:31494105
NCBI chr 8:6,133,014...6,204,240
Ensembl chr 8:6,135,493...6,203,579
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
19883
role
19833
biological role
19833
biochemical role
19370
cofactor
15580
porphyrins
343
beta-substituted porphyrin
24
(2R,2(1)S)-2(1),2(2)-dicarboxy-8-ethenyl-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-13,17-dipropanoic acid +
24
(2R,2(1)S)-8-ethenyl-2(1),2(2)-bis(methoxycarbonyl)-17-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-13-propanoic acid +
24
(2R,2(1)S)8-ethenyl-2(1),2(2)-bis(methoxycarbonyl)-13-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-17-propanoic acid +
24
(2S,2(1)R)-2(1),2(2)-dicarboxy-8-ethenyl-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-13,17-dipropanoic acid +
24
(2S,2(1)R)-8-ethenyl-2(1),2(2)-bis(methoxycarbonyl)-13-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-17-propanoic acid +
24
(2S,2(1)R)-8-ethenyl-2(1),2(2)-bis(methoxycarbonyl)-17-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-13-propanoic acid +
24
beta-borylporphyrin +
0
beta-bromoporphyrin +
0
beta-formylporphyrin +
0
porfimer
0
Path 2
CHEBI ontology
19883
subatomic particle
19881
composite particle
19881
hadron
19881
baryon
19881
nucleon
19881
atomic nucleus
19881
atom
19881
main group element atom
19771
p-block element atom
19771
carbon group element atom
19679
carbon atom
19668
organic molecular entity
19668
organic molecule
19596
organic cyclic compound
19407
organic heterocyclic compound
18517
organonitrogen heterocyclic compound
17582
polypyrrole
611
tetrapyrrole
499
cyclic tetrapyrrole
370
porphyrins
343
beta-substituted porphyrin
24
(2R,2(1)S)-2(1),2(2)-dicarboxy-8-ethenyl-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-13,17-dipropanoic acid +
24
(2R,2(1)S)-8-ethenyl-2(1),2(2)-bis(methoxycarbonyl)-17-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-13-propanoic acid +
24
(2R,2(1)S)8-ethenyl-2(1),2(2)-bis(methoxycarbonyl)-13-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-17-propanoic acid +
24
(2S,2(1)R)-2(1),2(2)-dicarboxy-8-ethenyl-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-13,17-dipropanoic acid +
24
(2S,2(1)R)-8-ethenyl-2(1),2(2)-bis(methoxycarbonyl)-13-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-17-propanoic acid +
24
(2S,2(1)R)-8-ethenyl-2(1),2(2)-bis(methoxycarbonyl)-17-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-13-propanoic acid +
24
beta-borylporphyrin +
0
beta-bromoporphyrin +
0
beta-formylporphyrin +
0
porfimer
0