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G |
CAT |
catalase |
multiple interactions |
ISO |
[clemizole co-treated with Cisplatin] results in decreased expression of CAT protein; clemizole inhibits the reaction [Cisplatin results in decreased expression of CAT protein] |
CTD |
PMID:37102204 |
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NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
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G |
CYP2B6 |
cytochrome P450 family 2 subfamily B member 6 |
increases expression multiple interactions |
EXP |
clemizole results in increased expression of CYP2B6 mRNA [clemizole co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA; [clemizole co-treated with NR1I3 protein mutant form] results in increased expression of CYP2B6 mRNA |
CTD |
PMID:31312845 |
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NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
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G |
CYP3A4 |
cytochrome P450 family 3 subfamily A member 4 |
multiple interactions increases expression |
EXP |
[clemizole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA clemizole results in increased expression of CYP3A4 mRNA |
CTD |
PMID:31312845 |
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NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
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G |
G6PC1 |
glucose-6-phosphatase catalytic subunit 1 |
increases expression |
EXP |
clemizole results in increased expression of G6PC1 mRNA |
CTD |
PMID:31312845 |
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NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438
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G |
LCN2 |
lipocalin 2 |
multiple interactions |
ISO |
[clemizole co-treated with Cisplatin] results in increased expression of LCN2 protein; clemizole inhibits the reaction [Cisplatin results in increased expression of LCN2 protein] |
CTD |
PMID:37102204 |
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NCBI chr 9:128,149,453...128,153,453
Ensembl chr 9:128,149,071...128,153,453
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G |
MED1 |
mediator complex subunit 1 |
multiple interactions |
EXP |
clemizole promotes the reaction [MED1 protein binds to NR1I3 protein alternative form] |
CTD |
PMID:31312845 |
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NCBI chr17:39,404,285...39,451,263
Ensembl chr17:39,404,285...39,451,272
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G |
NCOA1 |
nuclear receptor coactivator 1 |
multiple interactions |
EXP |
clemizole promotes the reaction [NCOA1 protein binds to NR1I3 protein alternative form]; clemizole promotes the reaction [NCOA1 protein binds to NR1I3 protein] |
CTD |
PMID:31312845 |
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NCBI chr 2:24,491,254...24,770,702
Ensembl chr 2:24,491,254...24,770,702
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G |
NCOA3 |
nuclear receptor coactivator 3 |
multiple interactions |
EXP |
clemizole promotes the reaction [NCOA3 protein binds to NR1I3 protein] |
CTD |
PMID:31312845 |
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NCBI chr20:47,501,887...47,656,872
Ensembl chr20:47,501,887...47,656,877
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G |
NPHS1 |
NPHS1 adhesion molecule, nephrin |
multiple interactions |
ISO |
[Cisplatin co-treated with clemizole] results in decreased expression of NPHS1 protein; clemizole inhibits the reaction [Cisplatin results in decreased expression of NPHS1 protein] |
CTD |
PMID:37102204 |
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NCBI chr19:35,862,915...35,869,357
Ensembl chr19:35,825,964...35,869,287
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G |
NR1I2 |
nuclear receptor subfamily 1 group I member 2 |
increases activity multiple interactions |
EXP |
clemizole results in increased activity of NR1I2 protein [clemizole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA |
CTD |
PMID:31312845 |
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NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487
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G |
NR1I3 |
nuclear receptor subfamily 1 group I member 3 |
affects binding multiple interactions affects localization |
EXP |
clemizole binds to NR1I3 protein [clemizole co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA; [clemizole co-treated with NR1I3 protein mutant form] results in increased expression of CYP2B6 mRNA; clemizole binds to and results in increased activity of NR1I3 protein alternative form; clemizole inhibits the reaction [ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate results in decreased activity of NR1I3 protein]; clemizole promotes the reaction [MED1 protein binds to NR1I3 protein alternative form]; clemizole promotes the reaction [NCOA1 protein binds to NR1I3 protein alternative form]; clemizole promotes the reaction [NCOA1 protein binds to NR1I3 protein]; clemizole promotes the reaction [NCOA3 protein binds to NR1I3 protein] clemizole affects the localization of NR1I3 protein mutant form |
CTD |
PMID:31312845 |
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NCBI chr 1:161,229,669...161,238,203
Ensembl chr 1:161,229,666...161,238,244
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G |
PCK1 |
phosphoenolpyruvate carboxykinase 1 |
increases expression |
EXP |
clemizole results in increased expression of PCK1 mRNA |
CTD |
PMID:31312845 |
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NCBI chr20:57,561,110...57,568,121
Ensembl chr20:57,561,080...57,568,121
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G |
RAC1 |
Rac family small GTPase 1 |
multiple interactions |
ISO |
clemizole inhibits the reaction [Cisplatin results in increased expression of RAC1 protein] |
CTD |
PMID:37102204 |
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NCBI chr 7:6,374,527...6,403,967
Ensembl chr 7:6,374,527...6,403,967
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G |
SCD |
stearoyl-CoA desaturase |
decreases expression |
EXP |
clemizole results in decreased expression of SCD mRNA |
CTD |
PMID:31312845 |
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NCBI chr10:100,347,233...100,364,826
Ensembl chr10:100,347,233...100,364,826
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G |
SYNPO |
synaptopodin |
multiple interactions |
ISO |
[Cisplatin co-treated with clemizole] results in decreased expression of SYNPO protein; clemizole inhibits the reaction [Cisplatin results in decreased expression of SYNPO protein] |
CTD |
PMID:37102204 |
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NCBI chr 5:150,586,010...150,659,207
Ensembl chr 5:150,601,080...150,659,207
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G |
THRSP |
thyroid hormone responsive |
affects expression |
EXP |
clemizole affects the expression of THRSP mRNA |
CTD |
PMID:31312845 |
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NCBI chr11:78,063,861...78,068,351
Ensembl chr11:78,063,861...78,068,351
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