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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:clemizole
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Accession:CHEBI:52140 term browser browse the term
Definition:A member of the class of benzimidazoles that is 1H-benzimidazole substituted by a pyrrolidin-1-ylmethyl and a 4-chlorobenzyl groups at positions 2 and 1 respectively.
Synonyms:exact_synonym: 1-(4-chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzimidazole
 related_synonym: 1-(p-Chlorobenzyl)-2-pyrrolidylmethylenebenzimidazole;   Depocural;   Formula=C19H20ClN3;   InChI=1S/C19H20ClN3/c20-16-9-7-15(8-10-16)13-23-18-6-2-1-5-17(18)21-19(23)14-22-11-3-4-12-22/h1-2,5-10H,3-4,11-14H2;   InChIKey=CJXAEXPPLWQRFR-UHFFFAOYSA-N;   Lergopenin;   SMILES=Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc23)cc1;   clemizol;   clemizolum
 xref: Beilstein:323050;   CAS:442-52-4;   Drug_Central:672;   LINCS:LSM-5225
 xref_mesh: MESH:C084582
 xref: PMID:10759334;   PMID:23143674;   Reaxys:323050;   Wikipedia:Clemizole
 cyclic_relationship: is_conjugate_base_of CHEBI:52146



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clemizole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase multiple interactions ISO [clemizole co-treated with Cisplatin] results in decreased expression of CAT protein; clemizole inhibits the reaction [Cisplatin results in decreased expression of CAT protein] CTD PMID:37102204 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 increases expression
multiple interactions
EXP clemizole results in increased expression of CYP2B6 mRNA
[clemizole co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA; [clemizole co-treated with NR1I3 protein mutant form] results in increased expression of CYP2B6 mRNA
CTD PMID:31312845 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions
increases expression
EXP [clemizole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
clemizole results in increased expression of CYP3A4 mRNA
CTD PMID:31312845 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G G6PC1 glucose-6-phosphatase catalytic subunit 1 increases expression EXP clemizole results in increased expression of G6PC1 mRNA CTD PMID:31312845 NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438
JBrowse link
G LCN2 lipocalin 2 multiple interactions ISO [clemizole co-treated with Cisplatin] results in increased expression of LCN2 protein; clemizole inhibits the reaction [Cisplatin results in increased expression of LCN2 protein] CTD PMID:37102204 NCBI chr 9:128,149,453...128,153,453
Ensembl chr 9:128,149,071...128,153,453
JBrowse link
G MED1 mediator complex subunit 1 multiple interactions EXP clemizole promotes the reaction [MED1 protein binds to NR1I3 protein alternative form] CTD PMID:31312845 NCBI chr17:39,404,285...39,451,263
Ensembl chr17:39,404,285...39,451,272
JBrowse link
G NCOA1 nuclear receptor coactivator 1 multiple interactions EXP clemizole promotes the reaction [NCOA1 protein binds to NR1I3 protein alternative form]; clemizole promotes the reaction [NCOA1 protein binds to NR1I3 protein] CTD PMID:31312845 NCBI chr 2:24,491,254...24,770,702
Ensembl chr 2:24,491,254...24,770,702
JBrowse link
G NCOA3 nuclear receptor coactivator 3 multiple interactions EXP clemizole promotes the reaction [NCOA3 protein binds to NR1I3 protein] CTD PMID:31312845 NCBI chr20:47,501,887...47,656,872
Ensembl chr20:47,501,887...47,656,877
JBrowse link
G NPHS1 NPHS1 adhesion molecule, nephrin multiple interactions ISO [Cisplatin co-treated with clemizole] results in decreased expression of NPHS1 protein; clemizole inhibits the reaction [Cisplatin results in decreased expression of NPHS1 protein] CTD PMID:37102204 NCBI chr19:35,862,915...35,869,357
Ensembl chr19:35,825,964...35,869,287
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity
multiple interactions
EXP clemizole results in increased activity of NR1I2 protein
[clemizole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:31312845 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487
JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 affects binding
multiple interactions
affects localization
EXP clemizole binds to NR1I3 protein
[clemizole co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA; [clemizole co-treated with NR1I3 protein mutant form] results in increased expression of CYP2B6 mRNA; clemizole binds to and results in increased activity of NR1I3 protein alternative form; clemizole inhibits the reaction [ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate results in decreased activity of NR1I3 protein]; clemizole promotes the reaction [MED1 protein binds to NR1I3 protein alternative form]; clemizole promotes the reaction [NCOA1 protein binds to NR1I3 protein alternative form]; clemizole promotes the reaction [NCOA1 protein binds to NR1I3 protein]; clemizole promotes the reaction [NCOA3 protein binds to NR1I3 protein]
clemizole affects the localization of NR1I3 protein mutant form
CTD PMID:31312845 NCBI chr 1:161,229,669...161,238,203
Ensembl chr 1:161,229,666...161,238,244
JBrowse link
G PCK1 phosphoenolpyruvate carboxykinase 1 increases expression EXP clemizole results in increased expression of PCK1 mRNA CTD PMID:31312845 NCBI chr20:57,561,110...57,568,121
Ensembl chr20:57,561,080...57,568,121
JBrowse link
G RAC1 Rac family small GTPase 1 multiple interactions ISO clemizole inhibits the reaction [Cisplatin results in increased expression of RAC1 protein] CTD PMID:37102204 NCBI chr 7:6,374,527...6,403,967
Ensembl chr 7:6,374,527...6,403,967
JBrowse link
G SCD stearoyl-CoA desaturase decreases expression EXP clemizole results in decreased expression of SCD mRNA CTD PMID:31312845 NCBI chr10:100,347,233...100,364,826
Ensembl chr10:100,347,233...100,364,826
JBrowse link
G SYNPO synaptopodin multiple interactions ISO [Cisplatin co-treated with clemizole] results in decreased expression of SYNPO protein; clemizole inhibits the reaction [Cisplatin results in decreased expression of SYNPO protein] CTD PMID:37102204 NCBI chr 5:150,586,010...150,659,207
Ensembl chr 5:150,601,080...150,659,207
JBrowse link
G THRSP thyroid hormone responsive affects expression EXP clemizole affects the expression of THRSP mRNA CTD PMID:31312845 NCBI chr11:78,063,861...78,068,351
Ensembl chr11:78,063,861...78,068,351
JBrowse link

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Path 1
Term Annotations click to browse term
  CHEBI ontology 26040
    role 25956
      biological role 25935
        pharmacological role 22053
          antagonist 18928
            histamine antagonist 5233
              clemizole 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 26040
    subatomic particle 26015
      composite particle 26015
        hadron 26015
          baryon 26015
            nucleon 26015
              atomic nucleus 26015
                atom 26015
                  main group element atom 25840
                    p-block element atom 25840
                      carbon group element atom 25441
                        carbon atom 25399
                          organic molecular entity 25399
                            organic molecule 25228
                              organic cyclic compound 24279
                                organic heterocyclic compound 22322
                                  organic heteropolycyclic compound 21309
                                    organic heterobicyclic compound 18572
                                      benzimidazoles 1169
                                        benzimidazole 373
                                          1H-benzimidazole 370
                                            clemizole 16
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