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ONTOLOGY REPORT - ANNOTATIONS


Term:clemizole
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Accession:CHEBI:52140 term browser browse the term
Definition:A member of the class of benzimidazoles that is 1H-benzimidazole substituted by a pyrrolidin-1-ylmethyl and a 4-chlorobenzyl groups at positions 2 and 1 respectively.
Synonyms:exact_synonym: 1-(4-chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzimidazole
 related_synonym: 1-(p-Chlorobenzyl)-2-pyrrolidylmethylenebenzimidazole;   Depocural;   Formula=C19H20ClN3;   InChI=1S/C19H20ClN3/c20-16-9-7-15(8-10-16)13-23-18-6-2-1-5-17(18)21-19(23)14-22-11-3-4-12-22/h1-2,5-10H,3-4,11-14H2;   InChIKey=CJXAEXPPLWQRFR-UHFFFAOYSA-N;   Lergopenin;   SMILES=Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc23)cc1;   clemizol;   clemizolum
 xref: Beilstein:323050 "Beilstein";   CAS:442-52-4 "ChemIDplus";   CAS:442-52-4 "NIST Chemistry WebBook";   Drug_Central:672 "DrugCentral";   LINCS:LSM-5225
 xref_mesh: MESH:C084582
 xref: PMID:10759334 "Europe PMC";   PMID:23143674 "Europe PMC";   Reaxys:323050 "Reaxys";   Wikipedia:Clemizole
 cyclic_relationship: is_conjugate_base_of CHEBI:52146


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clemizole term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 JBrowse link 1 83,163,103 83,236,615 RGD:6480464
G G6pc glucose-6-phosphatase, catalytic subunit JBrowse link 10 89,286,009 89,296,213 RGD:6480464
G Med1 mediator complex subunit 1 JBrowse link 10 86,101,560 86,145,271 RGD:6480464
G Ncoa1 nuclear receptor coactivator 1 JBrowse link 6 28,677,563 28,931,844 RGD:6480464
G Ncoa3 nuclear receptor coactivator 3 JBrowse link 3 162,692,176 162,788,582 RGD:6480464
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:6480464
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 JBrowse link 13 89,585,072 89,591,278 RGD:6480464
G Pck1 phosphoenolpyruvate carboxykinase 1 JBrowse link 3 171,213,936 171,219,885 RGD:6480464
G Scd stearoyl-CoA desaturase JBrowse link 1 264,159,966 264,173,061 RGD:6480464
G Thrsp thyroid hormone responsive JBrowse link 1 162,381,251 162,385,575 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19754
    role 19701
      biological role 19700
        pharmacological role 18807
          antagonist 16210
            histamine antagonist 4592
              clemizole 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19754
    subatomic particle 19752
      composite particle 19752
        hadron 19752
          baryon 19752
            nucleon 19752
              atomic nucleus 19752
                atom 19752
                  main group element atom 19637
                    p-block element atom 19637
                      carbon group element atom 19528
                        carbon atom 19517
                          organic molecular entity 19517
                            organic molecule 19436
                              organic cyclic compound 19199
                                organic heterocyclic compound 18276
                                  organic heteropolycyclic compound 17583
                                    organic heterobicyclic compound 16252
                                      benzimidazoles 827
                                        benzimidazole 64
                                          1H-benzimidazole 64
                                            clemizole 10
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.