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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hyodeoxycholic acid
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Accession:CHEBI:52023 term browser browse the term
Definition:A member of the class of 5beta-cholanic acids that is (5beta)-cholan-24-oic acid substituted by alpha-hydroxy groups at positions 3 and 6.
Synonyms:exact_synonym: 3alpha,6alpha-dihydroxy-5beta-cholan-24-oic acid
 related_synonym: 3alpha,6alpha-Dihydroxy-5beta-cholanic acid;   6alpha-Hydroxylithocholate;   7-Deoxyhyocholic acid;   Formula=C24H40O4;   Hyodesoxycholic acid;   InChI=1S/C24H40O4/c1-14(4-7-22(27)28)17-5-6-18-16-13-21(26)20-12-15(25)8-10-24(20,3)19(16)9-11-23(17,18)2/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16+,17-,18+,19+,20+,21+,23-,24-/m1/s1;   InChIKey=DGABKXLVXPYZII-SIBKNCMHSA-N;   Iodeoxycholic acid;   SMILES=[H][C@@]1(CC[C@@]2([H])[C@]3([H])C[C@H](O)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCC(O)=O
 xref: Beilstein:3218394;   CAS:83-49-8;   HMDB:HMDB0000733;   KEGG:C15517;   KNApSAcK:C00030498;   LIPID_MAPS_instance:LMST04010024
 xref_mesh: MESH:C010471
 xref: MetaCyc:CPD-7284;   PMID:18307294;   PMID:19711910;   PMID:23752203;   PMID:23756265;   Reaxys:3218394;   Wikipedia:Hyodeoxycholic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:58875

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hyodeoxycholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases secretion ISO AHR gene mutant form results in increased secretion of hyodeoxycholic acid CTD PMID:32679164 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions EXP [CYP2D6 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of hyodeoxycholic acid CTD PMID:18039809 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 increases abundance ISO HSD11B1 gene mutant form results in increased abundance of hyodeoxycholic acid CTD PMID:25061560 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation
affects metabolic processing
increases glycosylation
ISO UGT2B7 protein alternative form results in increased glucuronidation of hyodeoxycholic acid; UGT2B7 protein results in increased glucuronidation of hyodeoxycholic acid
UGT2B7 protein affects the metabolism of hyodeoxycholic acid
UGT2B7 protein results in increased glycosylation of hyodeoxycholic acid
CTD PMID:8423545, PMID:8517101, PMID:12527334, PMID:21415305 NCBI chr14:22,597,103...22,619,968 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    chemical entity 19816
      molecular entity 19814
        polyatomic entity 19727
          heteroatomic molecular entity 19653
            hydroxides 19107
              organic hydroxy compound 18661
                hydroxy-5beta-cholanic acid 919
                  bile acid 919
                    hyodeoxycholic acid 4
                      hyodeoxycholic acid 24-O-(beta-D-glucuronide) 0
                      hyodeoxycholic acid 6-O-(beta-D-glucuronide) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic polycyclic compound 16395
                                  steroid 12800
                                    steroid fundamental parent 12413
                                      cholane 920
                                        cholanoid 920
                                          cholanic acids 919
                                            cholanic acid 919
                                              5beta-cholanic acid 919
                                                hydroxy-5beta-cholanic acid 919
                                                  trihydroxy-5beta-cholanic acid 252
                                                    cholic acid 251
                                                      hyodeoxycholic acid 4
                                                        hyodeoxycholic acid 24-O-(beta-D-glucuronide) 0
                                                        hyodeoxycholic acid 6-O-(beta-D-glucuronide) 0
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