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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hyodeoxycholic acid
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Accession:CHEBI:52023 term browser browse the term
Definition:A member of the class of 5beta-cholanic acids that is (5beta)-cholan-24-oic acid substituted by alpha-hydroxy groups at positions 3 and 6.
Synonyms:exact_synonym: 3alpha,6alpha-dihydroxy-5beta-cholan-24-oic acid
 related_synonym: 3alpha,6alpha-Dihydroxy-5beta-cholanic acid;   6alpha-Hydroxylithocholate;   7-Deoxyhyocholic acid;   Formula=C24H40O4;   Hyodesoxycholic acid;   InChI=1S/C24H40O4/c1-14(4-7-22(27)28)17-5-6-18-16-13-21(26)20-12-15(25)8-10-24(20,3)19(16)9-11-23(17,18)2/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16+,17-,18+,19+,20+,21+,23-,24-/m1/s1;   InChIKey=DGABKXLVXPYZII-SIBKNCMHSA-N;   Iodeoxycholic acid;   SMILES=[H][C@@]1(CC[C@@]2([H])[C@]3([H])C[C@H](O)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCC(O)=O
 xref: Beilstein:3218394;   CAS:83-49-8;   HMDB:HMDB0000733;   KEGG:C15517;   KNApSAcK:C00030498;   LIPID_MAPS_instance:LMST04010024
 xref_mesh: MESH:C010471
 xref: MetaCyc:CPD-7284;   PMID:18307294;   PMID:19711910;   PMID:23752203;   PMID:23756265;   Reaxys:3218394;   Wikipedia:Hyodeoxycholic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:58875


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hyodeoxycholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases secretion ISO AHR gene mutant form results in increased secretion of hyodeoxycholic acid CTD PMID:32679164 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions EXP [CYP2D6 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of hyodeoxycholic acid CTD PMID:18039809 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Lithocholic Acid] which results in increased abundance of hyodeoxycholic acid CTD PMID:19487251 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 increases abundance ISO HSD11B1 gene mutant form results in increased abundance of hyodeoxycholic acid CTD PMID:25061560 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation
affects metabolic processing
increases glycosylation
ISO UGT2B7 protein alternative form results in increased glucuronidation of hyodeoxycholic acid; UGT2B7 protein results in increased glucuronidation of hyodeoxycholic acid
UGT2B7 protein affects the metabolism of hyodeoxycholic acid
UGT2B7 protein results in increased glycosylation of hyodeoxycholic acid
CTD PMID:8423545 PMID:8517101 PMID:12527334 PMID:21415305 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    chemical entity 19821
      molecular entity 19819
        polyatomic entity 19740
          heteroatomic molecular entity 19682
            hydroxides 19180
              organic hydroxy compound 18672
                hydroxy-5beta-cholanic acid 923
                  bile acid 923
                    hyodeoxycholic acid 5
                      hyodeoxycholic acid 24-O-(beta-D-glucuronide) 0
                      hyodeoxycholic acid 6-O-(beta-D-glucuronide) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic molecule 19569
                              organic cyclic compound 19360
                                organic polycyclic compound 16538
                                  steroid 13057
                                    steroid fundamental parent 12695
                                      cholane 939
                                        cholanoid 939
                                          cholanic acids 923
                                            cholanic acid 923
                                              5beta-cholanic acid 923
                                                hydroxy-5beta-cholanic acid 923
                                                  trihydroxy-5beta-cholanic acid 250
                                                    cholic acid 249
                                                      hyodeoxycholic acid 5
                                                        hyodeoxycholic acid 24-O-(beta-D-glucuronide) 0
                                                        hyodeoxycholic acid 6-O-(beta-D-glucuronide) 0
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