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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Fusaric acid
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Accession:CHEBI:5199 term browser browse the term
Definition:An aromatic carboxylic acid that has formula C10H13NO2.
Synonyms:related_synonym: Formula=C10H13NO2;   InChI=1S/C10H13NO2/c1-2-3-4-8-5-6-9(10(12)13)11-7-8/h5-7H,2-4H2,1H3,(H,12,13);   InChIKey=DGMPVYSXXIOGJY-UHFFFAOYSA-N;   SMILES=CCCCc1ccc(nc1)C(O)=O
 xref: CAS:536-69-6;   KEGG:C10146;   KNApSAcK:C00002040;   LINCS:LSM-3944
 xref_mesh: MESH:D005669


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Fusaric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases expression
multiple interactions 		EXP Fusaric Acid results in decreased expression of ACHE protein
Glycyrrhizic Acid inhibits the reaction [Fusaric Acid results in decreased expression of ACHE protein] 		CTD PMID:31150628 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects phosphorylation ISO Fusaric Acid affects the phosphorylation of AKT1 protein CTD PMID:32156565 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Atg5 autophagy related 5 increases expression ISO Fusaric Acid results in increased expression of ATG5 mRNA CTD PMID:30582969 NCBI chr20:49,380,835...49,471,826
Ensembl chr20:49,380,813...49,471,821 		JBrowse link
G Atg7 autophagy related 7 increases expression ISO Fusaric Acid results in increased expression of ATG7 mRNA CTD PMID:30582969 NCBI chr 4:149,390,000...149,597,534
Ensembl chr 4:149,391,390...149,598,319 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
decreases expression 		EXP Glycyrrhizic Acid inhibits the reaction [Fusaric Acid results in decreased expression of BDNF protein] CTD PMID:31150628 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657 		JBrowse link
G Casp1 caspase 1 decreases expression
affects activity 		ISO Fusaric Acid results in decreased expression of CASP1 mRNA
Fusaric Acid affects the activity of CASP1 protein 		CTD PMID:30582969 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275 		JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression 		EXP Glycyrrhizic Acid inhibits the reaction [Fusaric Acid results in decreased expression of CASP3 protein] CTD PMID:31150628 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Dbh dopamine beta-hydroxylase decreases activity EXP Fusaric Acid results in decreased activity of DBH protein CTD PMID:2724147 NCBI chr 3:30,886,313...30,903,313
Ensembl chr 3:30,886,328...30,903,316 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha decreases phosphorylation
increases phosphorylation 		ISO Fusaric Acid results in decreased phosphorylation of GSK3A protein
Fusaric Acid results in increased phosphorylation of GSK3A protein 		CTD PMID:32156565 NCBI chr 1:89,943,669...89,953,514
Ensembl chr 1:89,943,669...89,953,593 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation ISO Fusaric Acid results in increased phosphorylation of GSK3B protein CTD PMID:32156565 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
multiple interactions
affects expression 		ISO Fusaric Acid results in increased expression of HIF1A mRNA
Galactose affects the reaction [Fusaric Acid affects the expression of HIF1A protein]; Glucose affects the reaction [Fusaric Acid affects the expression of HIF1A protein] 		CTD PMID:31654802 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression ISO Fusaric Acid results in increased expression of HSPD1 protein CTD PMID:30582969 NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta decreases phosphorylation ISO Fusaric Acid results in decreased phosphorylation of IKBKB protein CTD PMID:30582969 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911 		JBrowse link
G Il1b interleukin 1 beta decreases expression
decreases secretion 		ISO Fusaric Acid results in decreased expression of IL1B mRNA
Fusaric Acid results in decreased secretion of IL1B protein 		CTD PMID:30582969 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 decreases expression ISO Fusaric Acid results in decreased expression of IRAK1 protein CTD PMID:30582969 NCBI chr  X:156,919,927...156,929,825
Ensembl chr  X:156,920,081...156,929,825 		JBrowse link
G Irak4 interleukin-1 receptor-associated kinase 4 decreases expression ISO Fusaric Acid results in decreased expression of IRAK4 protein CTD PMID:30582969 NCBI chr 7:127,561,777...127,588,762
Ensembl chr 7:127,561,717...127,597,109 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions
increases expression 		ISO Glucose affects the reaction [Fusaric Acid results in increased expression of LDHA mRNA] CTD PMID:31654802 NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521 		JBrowse link
G Mtor mechanistic target of rapamycin kinase affects phosphorylation ISO Fusaric Acid affects the phosphorylation of MTOR protein CTD PMID:32156565 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases phosphorylation ISO Fusaric Acid results in increased phosphorylation of NFE2L2 protein CTD PMID:30582969 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 decreases expression ISO Fusaric Acid results in decreased expression of NLRP3 mRNA CTD PMID:30582969 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394 		JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 increases phosphorylation
decreases phosphorylation 		ISO Fusaric Acid results in increased phosphorylation of PDHA1 protein
Fusaric Acid results in decreased phosphorylation of PDHA1 protein 		CTD PMID:31654802 PMID:32156565 NCBI chr  X:38,509,158...38,522,986
Ensembl chr  X:38,509,084...38,522,536 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 multiple interactions
increases expression
affects expression 		ISO Galactose affects the reaction [Fusaric Acid results in increased expression of PDK1 protein]; Glucose affects the reaction [Fusaric Acid results in increased expression of PDK1 mRNA]; Glucose affects the reaction [Fusaric Acid results in increased expression of PDK1 protein]
Fusaric Acid results in increased expression of PDK1 mRNA; Fusaric Acid results in increased expression of PDK1 protein
Fusaric Acid affects the expression of PDK1 protein 		CTD PMID:31654802 PMID:32156565 NCBI chr 3:77,113,464...77,144,145
Ensembl chr 3:77,113,473...77,144,145 		JBrowse link
G Pink1 PTEN induced kinase 1 increases expression ISO Fusaric Acid results in increased expression of PINK1 protein CTD PMID:30582969 NCBI chr 5:155,813,838...155,825,950
Ensembl chr 5:155,813,838...155,825,950 		JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions
increases expression 		ISO Galactose affects the reaction [Fusaric Acid results in increased expression of PKM mRNA]; Glucose affects the reaction [Fusaric Acid results in increased expression of PKM mRNA]; Glucose affects the reaction [Fusaric Acid results in increased expression of PKM protein]
Fusaric Acid results in increased expression of PKM mRNA; Fusaric Acid results in increased expression of PKM protein 		CTD PMID:31654802 NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:68,948,815...68,975,396 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression ISO Fusaric Acid results in increased expression of RELA mRNA CTD PMID:30582969 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 increases phosphorylation ISO Fusaric Acid results in increased phosphorylation of RPS6KB1 protein CTD PMID:32156565 NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,815,614...71,865,238 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 affects expression ISO Fusaric Acid affects the expression of SLC2A1 mRNA CTD PMID:32156565 NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression
affects expression 		ISO Fusaric Acid results in increased expression of SLC2A4 mRNA
Fusaric Acid affects the expression of SLC2A4 protein 		CTD PMID:32156565 NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO Fusaric Acid results in increased expression of SOD2 mRNA; Fusaric Acid results in increased expression of SOD2 protein CTD PMID:30582969 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Sqstm1 sequestosome 1 decreases expression ISO Fusaric Acid results in decreased expression of SQSTM1 protein CTD PMID:30582969 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750 		JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO Fusaric Acid results in increased expression of TFAM protein CTD PMID:30582969 NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,355,363...17,369,877 		JBrowse link
G Tp53 tumor protein p53 affects phosphorylation ISO Fusaric Acid affects the phosphorylation of TRP53 protein CTD PMID:32156565 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Traf6 TNF receptor associated factor 6 decreases expression ISO Fusaric Acid results in decreased expression of TRAF6 protein CTD PMID:30582969 NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:108,418,513...108,443,328 		JBrowse link
G Ucp2 uncoupling protein 2 decreases expression ISO Fusaric Acid results in decreased expression of UCP2 protein CTD PMID:30582969 NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:164,251,373...164,257,743 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    chemical entity 20860
      atom 20860
        nonmetal atom 20766
          nitrogen atom 19595
            nitrogen molecular entity 19595
              organonitrogen compound 19403
                organonitrogen heterocyclic compound 18546
                  pyridines 12234
                    Fusaric acid 34
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organochalcogen compound 19904
                                organooxygen compound 19806
                                  carbon oxoacid 19155
                                    carboxylic acid 19152
                                      aromatic carboxylic acid 14051
                                        Fusaric acid 34
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