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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Fusaric acid
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Accession:CHEBI:5199 term browser browse the term
Definition:An aromatic carboxylic acid that has formula C10H13NO2.
Synonyms:related_synonym: Formula=C10H13NO2;   InChI=1S/C10H13NO2/c1-2-3-4-8-5-6-9(10(12)13)11-7-8/h5-7H,2-4H2,1H3,(H,12,13);   InChIKey=DGMPVYSXXIOGJY-UHFFFAOYSA-N;   SMILES=CCCCc1ccc(nc1)C(O)=O
 xref: CAS:536-69-6;   KEGG:C10146;   KNApSAcK:C00002040;   LINCS:LSM-3944
 xref_mesh: MESH:D005669

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Fusaric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases expression
multiple interactions		 EXP Fusaric Acid results in decreased expression of ACHE protein
Glycyrrhizic Acid inhibits the reaction [Fusaric Acid results in decreased expression of ACHE protein]		 CTD PMID:31150628 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects phosphorylation ISO Fusaric Acid affects the phosphorylation of AKT1 protein CTD PMID:32156565 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Atg5 autophagy related 5 increases expression ISO Fusaric Acid results in increased expression of ATG5 mRNA CTD PMID:30582969 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140 		JBrowse link
G Atg7 autophagy related 7 increases expression ISO Fusaric Acid results in increased expression of ATG7 mRNA CTD PMID:30582969 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
decreases expression		 EXP Glycyrrhizic Acid inhibits the reaction [Fusaric Acid results in decreased expression of BDNF protein] CTD PMID:31150628 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210 		JBrowse link
G Casp1 caspase 1 decreases expression
affects activity		 ISO Fusaric Acid results in decreased expression of CASP1 mRNA
Fusaric Acid affects the activity of CASP1 protein		 CTD PMID:30582969 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631 		JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression		 EXP Glycyrrhizic Acid inhibits the reaction [Fusaric Acid results in decreased expression of CASP3 protein] CTD PMID:31150628 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Dbh dopamine beta-hydroxylase decreases activity EXP Fusaric Acid results in decreased activity of DBH protein CTD PMID:2724147 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha decreases phosphorylation
increases phosphorylation		 ISO Fusaric Acid results in decreased phosphorylation of GSK3A protein
Fusaric Acid results in increased phosphorylation of GSK3A protein		 CTD PMID:32156565 NCBI chr 1:82,097,244...82,108,238
Ensembl chr 1:82,097,247...82,108,203 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation ISO Fusaric Acid results in increased phosphorylation of GSK3B protein CTD PMID:32156565 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
affects expression
multiple interactions		 ISO Fusaric Acid results in increased expression of HIF1A mRNA
Fusaric Acid affects the expression of HIF1A protein
Galactose affects the reaction [Fusaric Acid affects the expression of HIF1A protein]; Glucose affects the reaction [Fusaric Acid affects the expression of HIF1A protein]		 CTD PMID:31654802 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression ISO Fusaric Acid results in increased expression of HSPD1 protein CTD PMID:30582969 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta decreases phosphorylation ISO Fusaric Acid results in decreased phosphorylation of IKBKB protein CTD PMID:30582969 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815 		JBrowse link
G Il1b interleukin 1 beta decreases expression
decreases secretion		 ISO Fusaric Acid results in decreased expression of IL1B mRNA
Fusaric Acid results in decreased secretion of IL1B protein		 CTD PMID:30582969 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 decreases expression ISO Fusaric Acid results in decreased expression of IRAK1 protein CTD PMID:30582969 NCBI chr  X:156,716,469...156,726,367
Ensembl chr  X:156,716,604...156,725,977 		JBrowse link
G Irak4 interleukin-1 receptor-associated kinase 4 decreases expression ISO Fusaric Acid results in decreased expression of IRAK4 protein CTD PMID:30582969 NCBI chr 7:135,803,723...135,831,006
Ensembl chr 7:135,803,698...135,832,652 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions
increases expression		 ISO Glucose affects the reaction [Fusaric Acid results in increased expression of LDHA mRNA] CTD PMID:31654802 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707 		JBrowse link
G Mtor mechanistic target of rapamycin kinase affects phosphorylation ISO Fusaric Acid affects the phosphorylation of MTOR protein CTD PMID:32156565 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases phosphorylation ISO Fusaric Acid results in increased phosphorylation of NFE2L2 protein CTD PMID:30582969 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 decreases expression ISO Fusaric Acid results in decreased expression of NLRP3 mRNA CTD PMID:30582969 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254 		JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 increases phosphorylation
decreases phosphorylation		 ISO Fusaric Acid results in increased phosphorylation of PDHA1 protein
Fusaric Acid results in decreased phosphorylation of PDHA1 protein		 CTD PMID:31654802 PMID:32156565 NCBI chr  X:37,329,779...37,343,410
Ensembl chr  X:37,329,779...37,343,410 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 multiple interactions
affects expression
increases expression		 ISO Galactose affects the reaction [Fusaric Acid results in increased expression of PDK1 protein]; Glucose affects the reaction [Fusaric Acid results in increased expression of PDK1 mRNA]; Glucose affects the reaction [Fusaric Acid results in increased expression of PDK1 protein]
Fusaric Acid affects the expression of PDK1 protein
Fusaric Acid results in increased expression of PDK1 mRNA; Fusaric Acid results in increased expression of PDK1 protein		 CTD PMID:31654802 PMID:32156565 NCBI chr 3:58,530,870...58,561,494
Ensembl chr 3:58,530,870...58,558,027 		JBrowse link
G Pink1 PTEN induced kinase 1 increases expression ISO Fusaric Acid results in increased expression of PINK1 protein CTD PMID:30582969 NCBI chr 5:156,677,146...156,689,258
Ensembl chr 5:156,677,146...156,689,415 		JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions
increases expression		 ISO Galactose affects the reaction [Fusaric Acid results in increased expression of PKM mRNA]; Glucose affects the reaction [Fusaric Acid results in increased expression of PKM mRNA]; Glucose affects the reaction [Fusaric Acid results in increased expression of PKM protein]
Fusaric Acid results in increased expression of PKM mRNA; Fusaric Acid results in increased expression of PKM protein		 CTD PMID:31654802 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression ISO Fusaric Acid results in increased expression of RELA mRNA CTD PMID:30582969 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 increases phosphorylation ISO Fusaric Acid results in increased phosphorylation of RPS6KB1 protein CTD PMID:32156565 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 affects expression ISO Fusaric Acid affects the expression of SLC2A1 mRNA CTD PMID:32156565 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression
affects expression		 ISO Fusaric Acid results in increased expression of SLC2A4 mRNA
Fusaric Acid affects the expression of SLC2A4 protein		 CTD PMID:32156565 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO Fusaric Acid results in increased expression of SOD2 mRNA; Fusaric Acid results in increased expression of SOD2 protein CTD PMID:30582969 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Sqstm1 sequestosome 1 decreases expression ISO Fusaric Acid results in decreased expression of SQSTM1 protein CTD PMID:30582969 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294 		JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO Fusaric Acid results in increased expression of TFAM protein CTD PMID:30582969 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151 		JBrowse link
G Tp53 tumor protein p53 affects phosphorylation ISO Fusaric Acid affects the phosphorylation of TRP53 protein CTD PMID:32156565 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Traf6 TNF receptor associated factor 6 decreases expression ISO Fusaric Acid results in decreased expression of TRAF6 protein CTD PMID:30582969 NCBI chr 3:91,252,829...91,271,607
Ensembl chr 3:91,252,829...91,271,607 		JBrowse link
G Ucp2 uncoupling protein 2 decreases expression ISO Fusaric Acid results in decreased expression of UCP2 protein CTD PMID:30582969 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    chemical entity 19770
      atom 19768
        nonmetal atom 19651
          nitrogen atom 18582
            nitrogen molecular entity 18582
              organonitrogen compound 18370
                organonitrogen heterocyclic compound 17526
                  pyridines 8428
                    Fusaric acid 34
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic group 18602
                              organic divalent group 18593
                                organodiyl group 18593
                                  carbonyl group 18506
                                    carbonyl compound 18506
                                      carboxylic acid 18158
                                        aromatic carboxylic acid 11263
                                          Fusaric acid 34
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