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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:organic polycyclic compound
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Accession:CHEBI:51958 term browser browse the term
Synonyms:related_synonym: organic polycyclic compounds


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16-Ketoestrone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DHRS4 dehydrogenase/reductase 4 increases reduction EXP DHRS4 protein results in increased reduction of 16-ketoestrone CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744
JBrowse link
17beta-estradiol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC2 ATP binding cassette subfamily C member 2 affects transport EXP ABCC2 protein affects the transport of Estradiol CTD PMID:15507541 NCBI chr28:12,670,885...12,740,124
Ensembl chr28:12,670,885...12,740,740
JBrowse link
G ESR1 estrogen receptor 1 affects expression EXP Estradiol affects the expression of ESR1 protein CTD PMID:16483645 NCBI chr 1:42,081,952...42,368,544
Ensembl chr 1:42,081,969...42,368,544
JBrowse link
17beta-estradiol 17-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1B3 solute carrier organic anion transporter family member 1B3 increases transport EXP SLCO1B3 protein results in increased transport of estradiol-17 beta-glucuronide CTD PMID:20079461 NCBI chr27:26,411,008...26,496,174
Ensembl chr27:26,411,010...26,470,989
JBrowse link
17beta-hydroxy-5alpha-androstan-3-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SOD2 superoxide dismutase 2 multiple interactions EXP Dihydrotestosterone promotes the reaction [Hydrogen Peroxide results in decreased activity of SOD2 protein] CTD PMID:16682413 NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706
JBrowse link
2,3,7,8-tetrachlorodibenzodioxine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions EXP [2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to Tetrachlorodibenzodioxin; [salicylamide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to Tetrachlorodibenzodioxin; [Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein CTD PMID:24389113 NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions EXP [Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein CTD PMID:24389113 NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression EXP Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA; Tetrachlorodibenzodioxin results in increased expression of PTGS2 protein CTD PMID:8660662 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
JBrowse link
G TERT telomerase reverse transcriptase decreases expression EXP Tetrachlorodibenzodioxin results in decreased expression of TERT protein CTD PMID:23850740 NCBI chr34:11,288,622...11,307,790
Ensembl chr34:11,288,622...11,307,951
JBrowse link
3-oxo-5beta-cholanic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DHRS4 dehydrogenase/reductase 4 decreases activity EXP 3-oxocholan-24-oic acid results in decreased activity of DHRS4 protein CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744
JBrowse link
9,10-phenanthroquinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DHRS4 dehydrogenase/reductase 4 increases reduction EXP DHRS4 protein results in increased reduction of 9,10-phenanthrenequinone CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744
JBrowse link
acenaphthoquinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DHRS4 dehydrogenase/reductase 4 increases reduction EXP DHRS4 protein results in increased reduction of acenaphthenequinone CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744
JBrowse link
aldosterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen increases abundance EXP AGT results in increased abundance of Aldosterone CTD PMID:2831029 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880
JBrowse link
G POMC proopiomelanocortin increases abundance EXP POMC protein results in increased abundance of Aldosterone CTD PMID:2831029 NCBI chr17:19,431,396...19,438,247
Ensembl chr17:19,431,585...19,434,440
JBrowse link
beta-naphthoflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases activity EXP beta-Naphthoflavone results in increased activity of CYP1A1 protein CTD PMID:3929785 NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866
JBrowse link
blebbistatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 decreases localization EXP blebbistatin results in decreased localization of ABCB11 protein CTD PMID:15826951 NCBI chr36:13,742,895...13,835,312
Ensembl chr36:13,746,964...13,834,974
JBrowse link
calcitriol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2 BCL2 apoptosis regulator affects expression EXP Calcitriol affects the expression of BCL2 protein CTD PMID:16080513 NCBI chr 1:13,733,849...13,900,653
Ensembl chr 1:13,731,406...13,900,658
JBrowse link
carprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression EXP carprofen results in decreased expression of PTGS2 mRNA CTD PMID:15198222 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
JBrowse link
carvedilol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 decreases activity EXP Carvedilol results in decreased activity of CASP3 protein CTD PMID:12875697 NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505
JBrowse link
G FAS Fas cell surface death receptor decreases expression EXP Carvedilol results in decreased expression of FAS CTD PMID:12875697 NCBI chr26:38,738,811...38,763,298
Ensembl chr26:38,737,611...38,763,321
JBrowse link
G FASLG Fas ligand decreases expression EXP Carvedilol results in decreased expression of FASLG CTD PMID:12875697 NCBI chr 7:26,335,837...26,344,224
Ensembl chr 7:26,335,846...26,344,224
JBrowse link
G NT5E 5'-nucleotidase ecto increases activity EXP Carvedilol results in increased activity of NT5E protein CTD PMID:15148268 NCBI chr12:45,491,028...45,520,019
Ensembl chr12:45,491,733...45,518,405
JBrowse link
G RYR2 ryanodine receptor 2 multiple interactions EXP Carvedilol results in decreased oxidation of and results in increased stability of RYR2 protein CTD PMID:17448375 NCBI chr 4:2,371,868...2,908,132
Ensembl chr 4:2,373,114...2,907,875
JBrowse link
cholanic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DHRS4 dehydrogenase/reductase 4 decreases activity EXP cholanic acid results in decreased activity of DHRS4 protein CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744
JBrowse link
cortisol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRH corticotropin releasing hormone increases abundance EXP CRH protein results in increased abundance of Hydrocortisone CTD PMID:2831029 NCBI chr29:15,831,944...15,840,560
Ensembl chr29:15,831,944...15,834,384
JBrowse link
G INS insulin affects abundance
multiple interactions
EXP INS protein affects the abundance of Hydrocortisone
Sodium affects the reaction [INS protein affects the abundance of Hydrocortisone]
CTD PMID:1324617 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122
JBrowse link
G POMC proopiomelanocortin increases abundance EXP POMC protein results in increased abundance of Hydrocortisone CTD PMID:2831029 NCBI chr17:19,431,396...19,438,247
Ensembl chr17:19,431,585...19,434,440
JBrowse link
desipramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2D15 cytochrome P450 2D affects metabolic processing EXP CYP2D15 affects the metabolism of Desipramine CTD PMID:7786018 NCBI chr10:23,255,259...23,259,380
Ensembl chr10:23,255,249...23,259,298
JBrowse link
dexamethasone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AVP arginine vasopressin decreases expression EXP Dexamethasone results in decreased expression of AVP protein CTD PMID:1934541 NCBI chr24:18,183,057...18,184,827
Ensembl chr24:18,183,057...18,184,883
JBrowse link
G HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 increases expression EXP Dexamethasone results in increased expression of HSD11B1 mRNA CTD PMID:21798686 NCBI chr 7:8,344,380...8,409,901
Ensembl chr 7:8,344,447...8,409,897
JBrowse link
G NPPA natriuretic peptide A increases expression EXP Dexamethasone results in increased expression of NPPA protein CTD PMID:1934541 NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385
JBrowse link
digoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions
increases response to substance
EXP [ML 7 results in decreased activity of MYLK protein] affects the reaction [ABCB1 protein affects the transport of Digoxin]; [Verapamil results in decreased activity of ABCB1 protein] which affects the transport of Digoxin; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of ALB mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of DAO mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of EBF3 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of GABRQ mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of GLRA1 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of KLK6 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of MAB21L2 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of SLC10A4 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of SLC18A2 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of TTR mRNA]; MYL9 protein modified form affects the reaction [ABCB1 protein affects the transport of Digoxin analog]
ABCB1 gene mutant form results in increased susceptibility to Digoxin; ABCB1 mutant form results in increased susceptibility to Digoxin
CTD PMID:16594604, PMID:20510202, PMID:23186803, PMID:25419811 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
JBrowse link
G ALB albumin multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of ALB mRNA] CTD PMID:25419811 NCBI chr13:62,133,747...62,169,349
Ensembl chr13:62,053,814...62,294,709
JBrowse link
G DAO D-amino acid oxidase multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of DAO mRNA] CTD PMID:25419811 NCBI chr26:18,032,663...18,057,277
Ensembl chr26:18,033,392...18,057,238
JBrowse link
G EBF3 EBF transcription factor 3 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of EBF3 mRNA] CTD PMID:25419811 NCBI chr28:38,489,635...38,601,800
Ensembl chr28:38,491,047...38,602,022
JBrowse link
G GABRQ gamma-aminobutyric acid type A receptor subunit theta multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of GABRQ mRNA] CTD PMID:25419811 NCBI chr  X:120,607,815...120,630,251
Ensembl chr  X:120,607,686...120,628,343
JBrowse link
G GLRA1 glycine receptor alpha 1 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of GLRA1 mRNA] CTD PMID:25419811 NCBI chr 4:57,443,094...57,541,494
Ensembl chr 4:57,443,999...57,528,376
JBrowse link
G INS insulin multiple interactions EXP [INS protein co-treated with Glucose] results in increased susceptibility to Digoxin; [INS protein co-treated with Glucose] results in increased uptake of Digoxin CTD PMID:140932, PMID:1013176 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122
JBrowse link
G KLK6 kallikrein related peptidase 6 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of KLK6 mRNA] CTD PMID:25419811 NCBI chr 1:105,902,147...105,907,585 JBrowse link
G MAB21L2 mab-21 like 2 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of MAB21L2 mRNA] CTD PMID:25419811 NCBI chr15:48,538,912...48,541,651
Ensembl chr15:48,539,955...48,541,034
JBrowse link
G MYL9 myosin light chain 9 multiple interactions EXP MYL9 protein modified form affects the reaction [ABCB1 protein affects the transport of Digoxin analog] CTD PMID:20510202 NCBI chr24:25,322,800...25,329,937
Ensembl chr24:25,322,800...25,329,932
JBrowse link
G MYLK myosin light chain kinase multiple interactions EXP [ML 7 results in decreased activity of MYLK protein] affects the reaction [ABCB1 protein affects the transport of Digoxin] CTD PMID:20510202 NCBI chr33:26,663,991...26,867,370
Ensembl chr33:26,664,800...26,843,181
JBrowse link
G SLC10A4 solute carrier family 10 member 4 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of SLC10A4 mRNA] CTD PMID:25419811 NCBI chr13:44,293,956...44,299,529
Ensembl chr13:44,277,094...44,299,732
JBrowse link
G SLC18A2 solute carrier family 18 member A2 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of SLC18A2 mRNA] CTD PMID:25419811 NCBI chr28:27,731,709...27,809,341
Ensembl chr28:27,731,004...27,767,993
JBrowse link
G TTR transthyretin multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of TTR mRNA] CTD PMID:25419811 NCBI chr 7:57,940,354...57,947,084
Ensembl chr 7:57,914,381...57,947,058
JBrowse link
diosgenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 multiple interactions EXP Diosgenin inhibits the reaction [Calcium Oxalate results in increased activity of CASP3 protein] CTD PMID:25446497 NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505
JBrowse link
G CASP9 caspase 9 multiple interactions EXP Diosgenin inhibits the reaction [Calcium Oxalate results in increased activity of CASP9 protein] CTD PMID:25446497 NCBI chr 2:82,033,759...82,076,710
Ensembl chr 2:82,031,563...82,090,484
JBrowse link
doxorubicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases expression
affects response to substance
multiple interactions
EXP Doxorubicin results in increased expression of ABCB1 protein
ABCB1 protein affects the susceptibility to Doxorubicin
valspodar inhibits the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]; valspodar inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]
CTD PMID:15492788, PMID:24975508, PMID:28093773 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
JBrowse link
G HGF hepatocyte growth factor decreases response to substance EXP HGF protein results in decreased susceptibility to Doxorubicin CTD PMID:15688034 NCBI chr18:21,329,688...21,410,257
Ensembl chr18:21,332,817...21,410,263
JBrowse link
G TNNT2 troponin T2, cardiac type affects expression EXP Doxorubicin affects the expression of TNNT2 protein CTD PMID:12322705 NCBI chr 7:1,598,306...1,620,531
Ensembl chr 7:1,598,306...1,613,741
JBrowse link
G VIP vasoactive intestinal peptide decreases expression EXP Doxorubicin results in decreased expression of VIP protein CTD PMID:3711722 NCBI chr 1:42,941,655...42,950,160
Ensembl chr 1:42,941,224...42,950,700
JBrowse link
G XIAP X-linked inhibitor of apoptosis affects response to substance EXP XIAP affects the susceptibility to Doxorubicin CTD PMID:16953886 NCBI chr  X:95,300,234...95,356,103
Ensembl chr  X:95,331,827...95,351,582
JBrowse link
eplerenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AR androgen receptor multiple interactions EXP Eplerenone binds to and results in decreased activity of AR protein CTD PMID:23242577 NCBI chr24:34,713,390...34,731,461
NCBI chr  X:51,969,785...52,167,450
Ensembl chr  X:51,969,785...52,151,912
JBrowse link
estrone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALPI alkaline phosphatase, intestinal increases chemical synthesis EXP ALPI protein results in increased chemical synthesis of Estrone CTD PMID:1495895 NCBI chr25:44,107,418...44,110,947 JBrowse link
estrone 3-sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1B3 solute carrier organic anion transporter family member 1B3 increases transport EXP SLCO1B3 protein results in increased transport of estrone sulfate CTD PMID:20079461 NCBI chr27:26,411,008...26,496,174
Ensembl chr27:26,411,010...26,470,989
JBrowse link
etodolac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression EXP Etodolac results in decreased expression of PTGS2 mRNA CTD PMID:15198222 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
JBrowse link
lithocholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DHRS4 dehydrogenase/reductase 4 decreases activity EXP Lithocholic Acid results in decreased activity of DHRS4 protein CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744
JBrowse link
Loratadine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 increases activity EXP Loratadine results in increased activity of CASP3 protein CTD PMID:20570632 NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505
JBrowse link
midazolam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 affects metabolic processing EXP CYP3A4 protein affects the metabolism of Midazolam; CYP3A5 protein affects the metabolism of Midazolam CTD PMID:15801540 NCBI chr 6:9,836,685...9,869,520
Ensembl chr 6:9,777,659...9,869,352
JBrowse link
nabilone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CNR2 cannabinoid receptor 2 affects binding EXP nabilone binds to CNR2 protein CTD PMID:21871882 NCBI chr 2:75,640,636...75,662,000
Ensembl chr 2:75,658,999...75,660,126
JBrowse link
ofloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAPN1 calpain 1 increases expression EXP Ofloxacin results in increased expression of CAPN1 mRNA CTD PMID:24582689 NCBI chr18:51,983,266...52,010,831
Ensembl chr18:51,983,824...52,010,757
JBrowse link
G CASP12 caspase 12 increases expression EXP Ofloxacin results in increased expression of CASP12 mRNA; Ofloxacin results in increased expression of CASP12 protein CTD PMID:24582689 NCBI chr 5:27,162,840...27,176,964
Ensembl chr 5:27,161,700...27,177,683
JBrowse link
G CASP8 caspase 8 multiple interactions
increases expression
EXP TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of CASP8 mRNA] CTD PMID:24582689 NCBI chr37:10,362,071...10,402,108
Ensembl chr37:10,391,048...10,401,822
JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression EXP Ofloxacin results in increased expression of DDIT3 mRNA CTD PMID:24582689 NCBI chr10:1,606,693...1,612,410
Ensembl chr10:1,606,693...1,611,303
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Ofloxacin results in increased expression of HSPA5 mRNA CTD PMID:24582689 NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257
JBrowse link
G TNF tumor necrosis factor increases expression EXP Ofloxacin results in increased expression of TNF mRNA; Ofloxacin results in increased expression of TNF protein CTD PMID:24582689 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A multiple interactions
increases expression
EXP TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of CASP8 mRNA]; TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of TRADD mRNA]
Ofloxacin results in increased expression of TNFRSF1A mRNA; Ofloxacin results in increased expression of TNFRSF1A protein
CTD PMID:24582689 NCBI chr27:38,641,837...38,654,693
Ensembl chr27:38,638,753...38,700,282
JBrowse link
G TRADD TNFRSF1A associated via death domain multiple interactions
increases expression
EXP TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of TRADD mRNA] CTD PMID:24582689 NCBI chr 5:82,200,430...82,211,430
Ensembl chr 5:82,206,111...82,210,963
JBrowse link
ouabain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin decreases secretion
multiple interactions
EXP Ouabain results in decreased secretion of REN protein
Vanadates inhibits the reaction [Ouabain results in decreased secretion of REN protein]
CTD PMID:6093556 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
progesterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ESR1 estrogen receptor 1 affects expression EXP Progesterone affects the expression of ESR1 protein CTD PMID:16483645 NCBI chr 1:42,081,952...42,368,544
Ensembl chr 1:42,081,969...42,368,544
JBrowse link
G PGR progesterone receptor affects binding EXP Progesterone binds to PGR protein CTD PMID:16054490 NCBI chr21:447,197...552,511
Ensembl chr21:447,319...552,511
JBrowse link
quinacrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HEXB hexosaminidase subunit beta multiple interactions EXP Quinacrine promotes the reaction [mastoparan results in increased secretion of HEXB protein] CTD PMID:21671308 NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417
JBrowse link
rifampicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases expression EXP Rifampin results in increased expression of ABCB1 mRNA; Rifampin results in increased expression of ABCB1 protein CTD PMID:22620706 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Rifampin results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347
JBrowse link
spironolactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator decreases expression EXP Spironolactone results in decreased expression of BAX protein CTD PMID:20082611 NCBI chr 1:107,423,388...107,426,464
Ensembl chr 1:107,422,424...107,426,464
JBrowse link
G BCL2 BCL2 apoptosis regulator increases expression EXP Spironolactone results in increased expression of BCL2 protein CTD PMID:20082611 NCBI chr 1:13,733,849...13,900,653
Ensembl chr 1:13,731,406...13,900,658
JBrowse link
G CAPN1 calpain 1 decreases expression EXP Spironolactone results in decreased expression of CAPN1 protein CTD PMID:20082611 NCBI chr18:51,983,266...52,010,831
Ensembl chr18:51,983,824...52,010,757
JBrowse link
G CASP3 caspase 3 decreases expression EXP Spironolactone results in decreased expression of CASP3 protein CTD PMID:20082611 NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505
JBrowse link
G CAST calpastatin increases expression EXP Spironolactone results in increased expression of CAST protein CTD PMID:20082611 NCBI chr 3:12,920,514...13,031,974
Ensembl chr 3:12,922,453...13,031,959
JBrowse link
G MMP9 matrix metallopeptidase 9 decreases expression EXP Spironolactone results in decreased expression of MMP9 protein CTD PMID:20082611 NCBI chr24:33,274,260...33,281,116
Ensembl chr24:33,274,268...33,281,293
JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 increases expression EXP Spironolactone results in increased expression of TIMP1 protein CTD PMID:20082611 NCBI chr  X:41,201,623...41,205,314
Ensembl chr  X:41,201,638...41,205,310
JBrowse link
taurocholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1B3 solute carrier organic anion transporter family member 1B3 increases transport EXP SLCO1B3 protein results in increased transport of Taurocholic Acid CTD PMID:20079461 NCBI chr27:26,411,008...26,496,174
Ensembl chr27:26,411,010...26,470,989
JBrowse link
testosterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B9D2 B9 domain containing 2 increases expression EXP Testosterone results in increased expression of TGFB1 mRNA CTD PMID:17157324 NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885
JBrowse link
G KCND3 potassium voltage-gated channel subfamily D member 3 increases expression EXP Testosterone results in increased expression of KCND3 protein CTD PMID:17054656 NCBI chr17:63,470,829...63,668,354
Ensembl chr17:63,470,415...63,668,035
JBrowse link
G KCNJ2 potassium inwardly rectifying channel subfamily J member 2 increases expression EXP Testosterone results in increased expression of KCNJ2 protein CTD PMID:17054656 NCBI chr 9:16,468,938...16,475,722
Ensembl chr 9:16,468,938...16,475,722
JBrowse link
thapsigargin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Thapsigargin results in increased expression of HSPA5 protein CTD PMID:17416481 NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257
JBrowse link
WIN 55212-2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CNR2 cannabinoid receptor 2 affects binding EXP Win 55212-2 binds to CNR2 protein CTD PMID:21871882 NCBI chr 2:75,640,636...75,662,000
Ensembl chr 2:75,658,999...75,660,126
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 227
    chemical entity 227
      group 220
        polyatomic entity 219
          molecule 205
            cyclic compound 186
              organic cyclic compound 186
                organic polycyclic compound 65
                  1-Methoxypyrene-6,7-oxide 0
                  7,8-Dihydropyrene-7-carboxylate 0
                  Luteoskyrin 0
                  Rugulosin 0
                  deltaline 0
                  hexacyclic triterpenoid + 2
                  hypocrellin D 0
                  organic tricyclic compound + 25
                  pentacyclic triterpenoid + 0
                  perylenes + 0
                  pyrenes + 0
                  sapogenin + 16
                  stemphyperylenol 0
                  steroid + 40
                  tetracenequinones + 5
                  tetracyclic triterpenoid + 0
                  tricyclic triterpenoid + 0
                  viridicatumtoxin 0
                  xanthoaphin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 227
    subatomic particle 227
      composite particle 227
        hadron 227
          baryon 227
            nucleon 227
              atomic nucleus 227
                atom 227
                  main group element atom 220
                    p-block element atom 220
                      p-block molecular entity 220
                        carbon group molecular entity 208
                          organic molecular entity 207
                            organic molecule 202
                              organic cyclic compound 186
                                organic polycyclic compound 65
                                  1-Methoxypyrene-6,7-oxide 0
                                  7,8-Dihydropyrene-7-carboxylate 0
                                  Luteoskyrin 0
                                  Rugulosin 0
                                  deltaline 0
                                  hexacyclic triterpenoid + 2
                                  hypocrellin D 0
                                  organic tricyclic compound + 25
                                  pentacyclic triterpenoid + 0
                                  perylenes + 0
                                  pyrenes + 0
                                  sapogenin + 16
                                  stemphyperylenol 0
                                  steroid + 40
                                  tetracenequinones + 5
                                  tetracyclic triterpenoid + 0
                                  tricyclic triterpenoid + 0
                                  viridicatumtoxin 0
                                  xanthoaphin 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.