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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:furazolidone
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Accession:CHEBI:5195 term browser browse the term
Definition:A member of the class of oxazolidines that is 1,3-oxazolidin-2-one in which the hydrogen attached to the nitrogen is replaced by an N-{[(5-nitro-2-furyl)methylene]amino} group. It has antibacterial and antiprotozoal properties, and is used in the treatment of giardiasis and cholera.
Synonyms:exact_synonym: 3-{[(5-nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one
 related_synonym: 3-(5'-Nitrofurfuralamino)-2-oxazolidone;   3-[(5-Nitrofurfurylidene)amino]-2-oxazolidinone;   3-[(5-Nitrofurfurylidene)amino]-2-oxazolidone;   3-[(5-Nitrofurylidene)amino]-2-oxazolidone;   3-{[(5-Nitro-2-furanyl)methylene]amino}-2-oxazolidinone;   5-Nitro-N-(2-oxo-3-oxazolidinyl)-2-furanmethanimine;   FZL;   Formula=C8H7N3O5;   Furazolidona;   Furazolidonum;   Furoxone;   InChI=1S/C8H7N3O5/c12-8-10(3-4-15-8)9-5-6-1-2-7(16-6)11(13)14/h1-2,5H,3-4H2;   InChIKey=PLHJDBGFXBMTGZ-UHFFFAOYSA-N;   N-(5-Nitro-2-furfurylidene)-3-amino-2-oxazolidone;   N-(5-Nitro-2-furfurylidene)-3-aminooxazolidine-2-one;   Nitrofurazolidone;   Nitrofurazolidonum;   SMILES=[O-][N+](=O)c1ccc(C=NN2CCOC2=O)o1
 xref: Beilstein:384794;   CAS:67-45-8;   DrugBank:DB00614;   Drug_Central:1257;   HMDB:HMDB0014752;   KEGG:C07999;   KEGG:D00830;   LINCS:LSM-6543
 xref_mesh: MESH:D005664
 xref: PMID:10735922;   PMID:14500876;   PMID:15666977;   PMID:16225499;   PMID:17422910;   PMID:21817887;   PMID:22024820;   PMID:22177019;   PMID:22221615;   PMID:22226073;   PMID:22228494;   PMID:22240115;   PMID:22249086;   PMID:22260837;   PMID:22362365;   PMID:22759325;   PMID:22829809;   PMID:22868168;   PMID:22877600;   PMID:23112108;   PMID:23151414;   PMID:23153221;   PMID:23261742;   PMID:23279258;   PMID:23285433;   PMID:23376004;   PMID:23403439;   PMID:23418857;   PMID:23429422;   PMID:23461927;   Patent:GB735136;   Patent:US2742462;   Patent:US2759931;   Patent:US2927110;   Reaxys:384794;   Wikipedia:Furazolidone


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furazolidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Furazolidone results in decreased phosphorylation of AKT1 protein]; IGF1 protein inhibits the reaction [Furazolidone results in decreased phosphorylation of AKT1 protein] CTD PMID:26687534 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Brca1 BRCA1, DNA repair associated multiple interactions
increases expression		 ISO Curcumin inhibits the reaction [Furazolidone results in increased expression of BRCA1 protein] CTD PMID:27996348 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO CDKN1A protein inhibits the reaction [Furazolidone results in increased activity of CASP3 protein] CTD PMID:26687534 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression		 ISO Curcumin inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND1 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND1 mRNA]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]
Furazolidone results in increased expression of CCND1 mRNA; Furazolidone results in increased expression of CCND1 protein		 CTD PMID:23112108 PMID:26095818 PMID:27996348 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd3 cyclin D3 multiple interactions
increases expression		 ISO GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND3 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND3 protein]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND3 mRNA]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND3 protein]
Furazolidone results in increased expression of CCND3 mRNA; Furazolidone results in increased expression of CCND3 protein		 CTD PMID:23112108 PMID:26095818 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 increases expression
multiple interactions		 ISO Furazolidone results in increased expression of CDK6 mRNA; Furazolidone results in increased expression of CDK6 protein
GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CDK6 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CDK6 protein]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CDK6 mRNA]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CDK6 protein]		 CTD PMID:23112108 PMID:26095818 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
decreases expression
increases expression		 ISO CDKN1A mutant form inhibits the reaction [Furazolidone results in increased expression of HMOX1 protein]; CDKN1A mutant form inhibits the reaction [Furazolidone results in increased expression of NFE2L2 protein]; CDKN1A protein inhibits the reaction [Furazolidone results in increased activity of CASP3 protein]; CDKN1A protein inhibits the reaction [Furazolidone results in increased phosphorylation of PARP1 protein]; CDKN1A protein promotes the reaction [Furazolidone results in increased expression of HMOX1 protein]; CDKN1A protein promotes the reaction [Furazolidone results in increased expression of NFE2L2 protein]; Furazolidone promotes the reaction [Cycloheximide results in decreased expression of CDKN1A protein]
Furazolidone results in decreased expression of CDKN1A protein
Furazolidone results in increased expression of CDKN1A mRNA		 CTD PMID:26687534 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions
increases expression		 ISO Curcumin inhibits the reaction [Furazolidone results in increased expression of CHEK1 protein] CTD PMID:27996348 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity EXP Furazolidone results in increased activity of CYP1A1 protein CTD PMID:8619122 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO Curcumin inhibits the reaction [Furazolidone results in increased expression of DDIT3 protein] CTD PMID:27996348 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions
increases expression		 ISO GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND1 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND3 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND3 protein]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CDK6 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CDK6 protein]
Furazolidone results in increased expression of GADD45A		 CTD PMID:26095818 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO CDKN1A mutant form inhibits the reaction [Furazolidone results in increased expression of HMOX1 protein]; CDKN1A protein promotes the reaction [Furazolidone results in increased expression of HMOX1 protein]; Curcumin promotes the reaction [Furazolidone results in increased expression of HMOX1 protein] CTD PMID:26687534 PMID:27996348 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions		 ISO Furazolidone results in increased expression of HSPA5 protein
Curcumin inhibits the reaction [Furazolidone results in increased expression of HSPA5 protein]		 CTD PMID:27996348 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO IGF1 protein inhibits the reaction [Furazolidone results in decreased phosphorylation of AKT1 protein] CTD PMID:26687534 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO Furazolidone results in increased phosphorylation of MAPK1 protein
Curcumin inhibits the reaction [Furazolidone results in increased phosphorylation of MAPK1 protein]		 CTD PMID:27996348 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression		 ISO CDKN1A mutant form inhibits the reaction [Furazolidone results in increased expression of NFE2L2 protein]; CDKN1A protein promotes the reaction [Furazolidone results in increased expression of NFE2L2 protein]; Curcumin promotes the reaction [Furazolidone results in increased expression of NFE2L2 protein] CTD PMID:26687534 PMID:27996348 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 ISO CDKN1A protein inhibits the reaction [Furazolidone results in increased phosphorylation of PARP1 protein]
Furazolidone results in increased cleavage of PARP1 protein		 CTD PMID:26687534 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19893
      biological role 19891
        antimicrobial agent 18273
          nitrofuran antibiotic 52
            furazolidone 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19865
                    p-block element atom 19865
                      carbon group element atom 19804
                        carbon atom 19801
                          organic molecular entity 19801
                            organic molecule 19754
                              organic cyclic compound 19544
                                organic heterocyclic compound 18909
                                  organic heteromonocyclic compound 17831
                                    furans 8661
                                      nitrofuran antibiotic 52
                                        furazolidone 17
paths to the root