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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:furazolidone
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Accession:CHEBI:5195 term browser browse the term
Definition:A member of the class of oxazolidines that is 1,3-oxazolidin-2-one in which the hydrogen attached to the nitrogen is replaced by an N-{[(5-nitro-2-furyl)methylene]amino} group. It has antibacterial and antiprotozoal properties, and is used in the treatment of giardiasis and cholera.
Synonyms:exact_synonym: 3-{[(5-nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one
 related_synonym: 3-(5'-Nitrofurfuralamino)-2-oxazolidone;   3-[(5-Nitrofurfurylidene)amino]-2-oxazolidinone;   3-[(5-Nitrofurfurylidene)amino]-2-oxazolidone;   3-[(5-Nitrofurylidene)amino]-2-oxazolidone;   3-{[(5-Nitro-2-furanyl)methylene]amino}-2-oxazolidinone;   5-Nitro-N-(2-oxo-3-oxazolidinyl)-2-furanmethanimine;   FZL;   Formula=C8H7N3O5;   Furazolidona;   Furazolidonum;   Furoxone;   InChI=1S/C8H7N3O5/c12-8-10(3-4-15-8)9-5-6-1-2-7(16-6)11(13)14/h1-2,5H,3-4H2;   InChIKey=PLHJDBGFXBMTGZ-UHFFFAOYSA-N;   N-(5-Nitro-2-furfurylidene)-3-amino-2-oxazolidone;   N-(5-Nitro-2-furfurylidene)-3-aminooxazolidine-2-one;   Nitrofurazolidone;   Nitrofurazolidonum;   SMILES=[O-][N+](=O)c1ccc(C=NN2CCOC2=O)o1
 xref: Beilstein:384794;   CAS:67-45-8;   DrugBank:DB00614;   Drug_Central:1257;   HMDB:HMDB0014752;   KEGG:C07999;   KEGG:D00830;   LINCS:LSM-6543
 xref_mesh: MESH:D005664
 xref: PMID:10735922;   PMID:14500876;   PMID:15666977;   PMID:16225499;   PMID:17422910;   PMID:21817887;   PMID:22024820;   PMID:22177019;   PMID:22221615;   PMID:22226073;   PMID:22228494;   PMID:22240115;   PMID:22249086;   PMID:22260837;   PMID:22362365;   PMID:22759325;   PMID:22829809;   PMID:22868168;   PMID:22877600;   PMID:23112108;   PMID:23151414;   PMID:23153221;   PMID:23261742;   PMID:23279258;   PMID:23285433;   PMID:23376004;   PMID:23403439;   PMID:23418857;   PMID:23429422;   PMID:23461927;   Patent:GB735136;   Patent:US2742462;   Patent:US2759931;   Patent:US2927110;   Reaxys:384794;   Wikipedia:Furazolidone


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furazolidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Furazolidone results in decreased phosphorylation of AKT1 protein]; IGF1 protein inhibits the reaction [Furazolidone results in decreased phosphorylation of AKT1 protein] CTD PMID:26687534 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO CDKN1A protein inhibits the reaction [Furazolidone results in increased activity of CASP3 protein] CTD PMID:26687534 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
ISO GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND1 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND1 mRNA]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]
Furazolidone results in increased expression of CCND1 mRNA; Furazolidone results in increased expression of CCND1 protein
CTD PMID:23112108 PMID:26095818 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd3 cyclin D3 multiple interactions
increases expression
ISO GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND3 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND3 protein]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND3 mRNA]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND3 protein]
Furazolidone results in increased expression of CCND3 mRNA; Furazolidone results in increased expression of CCND3 protein
CTD PMID:23112108 PMID:26095818 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Cdk6 cyclin-dependent kinase 6 increases expression
multiple interactions
ISO Furazolidone results in increased expression of CDK6 mRNA; Furazolidone results in increased expression of CDK6 protein
GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CDK6 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CDK6 protein]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CDK6 mRNA]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CDK6 protein]
CTD PMID:23112108 PMID:26095818 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
decreases expression
increases expression
ISO CDKN1A mutant form inhibits the reaction [Furazolidone results in increased expression of HMOX1 protein]; CDKN1A mutant form inhibits the reaction [Furazolidone results in increased expression of NFE2L2 protein]; CDKN1A protein inhibits the reaction [Furazolidone results in increased activity of CASP3 protein]; CDKN1A protein inhibits the reaction [Furazolidone results in increased phosphorylation of PARP1 protein]; CDKN1A protein promotes the reaction [Furazolidone results in increased expression of HMOX1 protein]; CDKN1A protein promotes the reaction [Furazolidone results in increased expression of NFE2L2 protein]; Furazolidone promotes the reaction [Cycloheximide results in decreased expression of CDKN1A protein]
Furazolidone results in decreased expression of CDKN1A protein
Furazolidone results in increased expression of CDKN1A mRNA
CTD PMID:26687534 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity EXP Furazolidone results in increased activity of CYP1A1 protein CTD PMID:8619122 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions
increases expression
ISO GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND1 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND3 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND3 protein]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CDK6 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CDK6 protein]
Furazolidone results in increased expression of GADD45A
CTD PMID:26095818 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO CDKN1A mutant form inhibits the reaction [Furazolidone results in increased expression of HMOX1 protein]; CDKN1A protein promotes the reaction [Furazolidone results in increased expression of HMOX1 protein] CTD PMID:26687534 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO IGF1 protein inhibits the reaction [Furazolidone results in decreased phosphorylation of AKT1 protein] CTD PMID:26687534 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression
ISO CDKN1A mutant form inhibits the reaction [Furazolidone results in increased expression of NFE2L2 protein]; CDKN1A protein promotes the reaction [Furazolidone results in increased expression of NFE2L2 protein] CTD PMID:26687534 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO CDKN1A protein inhibits the reaction [Furazolidone results in increased phosphorylation of PARP1 protein]
Furazolidone results in increased cleavage of PARP1 protein
CTD PMID:26687534 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        antimicrobial agent 17329
          nitrofuran antibiotic 44
            furazolidone 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic molecule 19514
                              organic cyclic compound 19311
                                organic heterocyclic compound 18425
                                  organic heteromonocyclic compound 16467
                                    furans 4136
                                      nitrofuran antibiotic 44
                                        furazolidone 12
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