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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:formamidines
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Accession:CHEBI:51917 term browser browse the term
Definition:Amidines with the general formula R(1)N=CHNR(2)R(3) (R(1), R(2), R(3) can be H).
Synonyms:related_synonym: Formula=CHN2R3;   SMILES=[H]C(=N[*])N([*])[*]


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amitraz term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A multiple interactions
decreases activity
EXP
ISO
[Idazoxan binds to and results in decreased activity of ADRA2A protein] which results in decreased susceptibility to amitraz; amitraz binds to and results in increased activity of ADRA2A protein
amitraz results in decreased activity of ADRA2A protein
CTD PMID:10582558 PMID:21251949 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
JBrowse link
G Cat catalase decreases expression
multiple interactions
EXP amitraz results in decreased expression of CAT protein
KEAP1 protein affects the reaction [amitraz results in decreased expression of CAT protein]
CTD PMID:31029719 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Comt catechol-O-methyltransferase multiple interactions
affects expression
EXP Tamoxifen inhibits the reaction [amitraz affects the expression of COMT mRNA]; Tamoxifen inhibits the reaction [amitraz affects the expression of COMT protein]
amitraz affects the expression of COMT mRNA; amitraz affects the expression of COMT protein
CTD PMID:28463726 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression EXP amitraz results in increased expression of CYP19A1 mRNA; amitraz results in increased expression of CYP19A1 protein CTD PMID:28463726 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP amitraz results in increased expression of CYP1A1 protein CTD PMID:15350676 PMID:31029719 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP amitraz results in increased expression of CYP1A2 protein CTD PMID:15350676 PMID:31029719 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP amitraz results in increased expression of CYP2B1 protein CTD PMID:15350676 PMID:31029719 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP amitraz results in increased expression of CYP2B2 protein CTD PMID:15350676 PMID:31029719 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression EXP amitraz results in increased expression of CYP2E1 protein CTD PMID:31029719 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP amitraz results in increased expression of CYP3A23-3A1 protein CTD PMID:31029719 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Dbh dopamine beta-hydroxylase multiple interactions
increases expression
EXP Tamoxifen inhibits the reaction [amitraz results in increased expression of DBH mRNA]; Tamoxifen inhibits the reaction [amitraz results in increased expression of DBH protein]
amitraz results in increased expression of DBH mRNA; amitraz results in increased expression of DBH protein
CTD PMID:28463726 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO amitraz inhibits the reaction [Spiperone binds to DRD2 protein] CTD PMID:2833825 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Gad2 glutamate decarboxylase 2 affects expression
multiple interactions
EXP amitraz affects the expression of GAD2 mRNA
[methylhistaprodifen co-treated with Idazoxan] inhibits the reaction [amitraz affects the expression of GAD2 mRNA]; Idazoxan inhibits the reaction [amitraz affects the expression of GAD2 mRNA]; methylhistaprodifen inhibits the reaction [amitraz affects the expression of GAD2 mRNA]
CTD PMID:26141220 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155
JBrowse link
G Gcg glucagon increases secretion EXP amitraz results in increased secretion of GCG protein CTD PMID:10582558 NCBI chr 3:47,113,914...47,122,929
Ensembl chr 3:47,113,914...47,122,929
JBrowse link
G Gls glutaminase multiple interactions
increases expression
EXP [methylhistaprodifen co-treated with Idazoxan] inhibits the reaction [amitraz results in increased expression of GLS mRNA]; methylhistaprodifen inhibits the reaction [amitraz results in increased expression of GLS mRNA] CTD PMID:26141220 NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases expression
multiple interactions
EXP amitraz results in increased expression of KEAP1 protein
KEAP1 protein affects the reaction [amitraz results in decreased expression of CAT protein]; KEAP1 protein affects the reaction [amitraz results in decreased expression of NFE2L2 protein]; KEAP1 protein affects the reaction [amitraz results in decreased expression of NQO1 protein]; KEAP1 protein affects the reaction [amitraz results in decreased expression of SOD1 protein]
CTD PMID:31029719 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Lhb luteinizing hormone subunit beta increases expression EXP amitraz results in increased expression of LHB protein CTD PMID:16085667 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Maoa monoamine oxidase A multiple interactions
decreases expression
EXP Tamoxifen inhibits the reaction [amitraz results in decreased expression of MAOA mRNA]; Tamoxifen inhibits the reaction [amitraz results in decreased expression of MAOA protein]
amitraz results in decreased expression of MAOA mRNA; amitraz results in decreased expression of MAOA protein
CTD PMID:28463726 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593
JBrowse link
G Maob monoamine oxidase B decreases expression
multiple interactions
EXP amitraz results in decreased expression of MAOB mRNA; amitraz results in decreased expression of MAOB protein
Tamoxifen inhibits the reaction [amitraz results in decreased expression of MAOB mRNA]; Tamoxifen inhibits the reaction [amitraz results in decreased expression of MAOB protein]
CTD PMID:28463726 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases expression
multiple interactions
EXP amitraz results in decreased expression of NFE2L2 protein
KEAP1 protein affects the reaction [amitraz results in decreased expression of NFE2L2 protein]
CTD PMID:31029719 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases expression
multiple interactions
EXP amitraz results in decreased expression of NQO1 protein
KEAP1 protein affects the reaction [amitraz results in decreased expression of NQO1 protein]
CTD PMID:31029719 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Por cytochrome p450 oxidoreductase increases activity EXP amitraz results in increased activity of POR protein CTD PMID:15350676 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO amitraz inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression
multiple interactions
EXP amitraz results in decreased expression of SOD1 protein
KEAP1 protein affects the reaction [amitraz results in decreased expression of SOD1 protein]
CTD PMID:31029719 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Th tyrosine hydroxylase multiple interactions
increases expression
EXP Tamoxifen inhibits the reaction [amitraz results in increased expression of TH mRNA]; Tamoxifen inhibits the reaction [amitraz results in increased expression of TH protein]
amitraz results in increased expression of TH mRNA; amitraz results in increased expression of TH protein
CTD PMID:28463726 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
formetanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP formetanate results in decreased activity of ACHE protein CTD PMID:19934164 PMID:21251949 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Bche butyrylcholinesterase multiple interactions EXP [Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein CTD PMID:22649187 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A decreases expression ISO formetanate results in decreased expression of HSPA1A protein CTD PMID:16271832
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO formetanate results in increased expression of HSPA5 protein CTD PMID:16271832 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 decreases expression ISO formetanate results in decreased expression of HSPA8 protein CTD PMID:16271832 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity ISO formetanate results in increased activity of NFE2L2 protein CTD PMID:20143881 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
N'-(2,4-dimethylphenyl)-N-methylformamidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases expression
multiple interactions
EXP U 40481 results in decreased expression of CAT protein
KEAP1 protein affects the reaction [U 40481 results in decreased expression of CAT protein]
CTD PMID:31029719 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP U 40481 results in increased expression of CYP1A1 protein CTD PMID:31029719 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP U 40481 results in increased expression of CYP1A2 protein CTD PMID:31029719 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP U 40481 results in increased expression of CYP2B1 protein CTD PMID:31029719 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP U 40481 results in increased expression of CYP2B2 protein CTD PMID:31029719 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression EXP U 40481 results in increased expression of CYP2E1 protein CTD PMID:31029719 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP U 40481 results in increased expression of CYP3A23-3A1 protein CTD PMID:31029719 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Gcg glucagon increases secretion EXP U 40481 results in increased secretion of GCG protein CTD PMID:10582558 NCBI chr 3:47,113,914...47,122,929
Ensembl chr 3:47,113,914...47,122,929
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases expression
multiple interactions
EXP U 40481 results in increased expression of KEAP1 protein
KEAP1 protein affects the reaction [U 40481 results in decreased expression of CAT protein]; KEAP1 protein affects the reaction [U 40481 results in decreased expression of NFE2L2 protein]; KEAP1 protein affects the reaction [U 40481 results in decreased expression of NQO1 protein]; KEAP1 protein affects the reaction [U 40481 results in decreased expression of SOD1 protein]
CTD PMID:31029719 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
decreases expression
EXP KEAP1 protein affects the reaction [U 40481 results in decreased expression of NFE2L2 protein] CTD PMID:31029719 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases expression
multiple interactions
EXP U 40481 results in decreased expression of NQO1 protein
KEAP1 protein affects the reaction [U 40481 results in decreased expression of NQO1 protein]
CTD PMID:31029719 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases expression
EXP KEAP1 protein affects the reaction [U 40481 results in decreased expression of SOD1 protein] CTD PMID:31029719 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    chemical entity 19821
      atom 19819
        nonmetal atom 19707
          nitrogen atom 18765
            nitrogen molecular entity 18765
              amidine 841
                carboxamidine 835
                  formamidines 30
                    2,2-dimethylpropanoyloxymethyl (2S,5S,6R)-6-(azepan-1-ylmethylideneamino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 0
                    4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-N-[(methoxyamino)methylidene]-2-methylbenzamide + 0
                    N'-(2,4-dimethylphenyl)-N-methylformamidine 12
                    N'-(3-hydroxyphenyl)-N,N-dimethylformamidine + 6
                    amitraz 25
                    formamidine + 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            heteroorganic entity 19294
                              organonitrogen compound 18538
                                carboxamidine 835
                                  formamidines 30
                                    2,2-dimethylpropanoyloxymethyl (2S,5S,6R)-6-(azepan-1-ylmethylideneamino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 0
                                    4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-N-[(methoxyamino)methylidene]-2-methylbenzamide + 0
                                    N'-(2,4-dimethylphenyl)-N-methylformamidine 12
                                    N'-(3-hydroxyphenyl)-N,N-dimethylformamidine + 6
                                    amitraz 25
                                    formamidine + 6
paths to the root