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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:organic heterohexacyclic compound
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Accession:CHEBI:51914 term browser browse the term
Synonyms:related_synonym: organic heterohexacyclic compounds


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caracurine VII term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm2 cholinergic receptor, muscarinic 2 affects binding ISO caracurine binds to CHRM2 protein CTD PMID:15647330 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 affects binding ISO caracurine binds to CHRM3 protein CTD PMID:15647330 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
ginkgolide B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
multiple interactions
ISO ginkgolide B results in increased expression of ABCB1 mRNA
NR1I2 protein affects the reaction [ginkgolide B results in increased expression of ABCB1 mRNA]; sulforaphane inhibits the reaction [ginkgolide B results in increased expression of ABCB1 mRNA]
CTD PMID:19034627 PMID:26775663 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO ginkgolide B results in increased expression of ABCC2 mRNA CTD PMID:19034627 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO ginkgolide B inhibits the reaction [APP protein results in increased phosphorylation of and results in increased activity of AKT1 protein] CTD PMID:19464278 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Apoe apolipoprotein E multiple interactions ISO ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the activity of GPT protein]; ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of FTH1 protein]; ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of GPX4 protein]; ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of HMOX1 protein]; ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of NFE2L2 protein]; ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of TFRC protein] CTD PMID:32976958 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO ginkgolide B inhibits the reaction [APP protein results in increased abundance of Reactive Oxygen Species]; ginkgolide B inhibits the reaction [APP protein results in increased cleavage of and results in increased activity of CASP3 protein]; ginkgolide B inhibits the reaction [APP protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; ginkgolide B inhibits the reaction [APP protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; ginkgolide B inhibits the reaction [APP protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; ginkgolide B inhibits the reaction [APP protein results in increased phosphorylation of and results in increased activity of MAPK8 protein] CTD PMID:19464278 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
ginkgolide B inhibits the reaction [APP protein results in increased cleavage of and results in increased activity of CASP3 protein]; ginkgolide B inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; ginkgolide B inhibits the reaction [Staurosporine results in increased cleavage of CASP3 protein]
ginkgolide B inhibits the reaction [Ethanol results in increased activity of CASP3 protein]
CTD PMID:19464278 PMID:21704112 PMID:26775663 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP ginkgolide B inhibits the reaction [Ethanol results in increased expression of NOX2 protein] CTD PMID:21704112 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:21329749 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression
EXP ginkgolide B results in increased expression of and results in increased activity of CYP1A2 protein
ginkgolide B results in increased expression of CYP1A2 mRNA
CTD PMID:18421621 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO ginkgolide B results in increased expression of CYP2B6 mRNA CTD PMID:19034627 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Fcer1g Fc fragment of IgE receptor Ig decreases expression EXP ginkgolide B results in decreased expression of FCER1G protein CTD PMID:1834581 NCBI chr13:89,601,894...89,606,326
Ensembl chr13:89,601,896...89,606,326
JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions ISO ginkgolide B inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of FTH1 protein]
ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of FTH1 protein]
CTD PMID:32976958 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO ginkgolide B inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in increased activity of GPT protein]
ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the activity of GPT protein]
CTD PMID:32976958 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of GPX4 protein]
ginkgolide B inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of GPX4 protein]
CTD PMID:32976958 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of HMOX1 protein]
ginkgolide B inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of HMOX1 protein]
CTD PMID:32976958 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO ginkgolide B inhibits the reaction [APP protein results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:19464278 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO ginkgolide B inhibits the reaction [APP protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:19464278 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO ginkgolide B inhibits the reaction [APP protein results in increased phosphorylation of and results in increased activity of MAPK8 protein] CTD PMID:19464278 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions EXP ginkgolide B inhibits the reaction [Ethanol results in increased expression of NCF1 protein] CTD PMID:21704112 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of NFE2L2 protein]
ginkgolide B inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of and affects the localization of NFE2L2 protein]
CTD PMID:32976958 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP ginkgolide B inhibits the reaction [Cyclophosphamide results in increased activity of NOS2 protein] CTD PMID:9006340 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to NOX4 promoter]]; ginkgolide B inhibits the reaction [Cisplatin results in increased expression of NOX4 mRNA]; ginkgolide B inhibits the reaction [Cisplatin results in increased expression of NOX4 protein]; MIR214 mRNA affects the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of NOX4 mRNA]]; TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to NOX4 promoter]]]; TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of NOX4 mRNA]] CTD PMID:26768586 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
affects localization
ISO ginkgolide B results in increased activity of NR1I2 protein
NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE mRNA]]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE protein]]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]]; NR1I2 protein affects the reaction [ginkgolide B results in increased expression of ABCB1 mRNA]; NR1I2 protein affects the reaction [ginkgolide B results in increased expression of CYP3A4 mRNA]
ginkgolide B affects the localization of NR1I2 protein
CTD PMID:19034627 PMID:26775663 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Sele selectin E multiple interactions ISO ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE protein]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE mRNA]]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE protein]] CTD PMID:26775663 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Shc1 SHC adaptor protein 1 multiple interactions ISO ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to SHC1 promoter]]; ginkgolide B inhibits the reaction [Cisplatin results in increased expression of SHC1 mRNA]; ginkgolide B inhibits the reaction [Cisplatin results in increased expression of SHC1 protein]; MIR214 mRNA affects the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of SHC1 mRNA]]; TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to SHC1 promoter]]]; TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of SHC1 mRNA]] CTD PMID:26768586 NCBI chr 2:188,745,503...188,757,066
Ensembl chr 2:188,745,503...188,757,066
JBrowse link
G Tfrc transferrin receptor multiple interactions ISO ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of TFRC protein]
ginkgolide B inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in increased expression of TFRC protein]
CTD PMID:32976958 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE protein]; ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE mRNA]]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE protein]]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]] CTD PMID:26775663 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to NOX4 promoter]]; ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to SHC1 promoter]]; ginkgolide B inhibits the reaction [Cisplatin results in increased expression of TRP53 mRNA]; ginkgolide B inhibits the reaction [Cisplatin results in increased expression of TRP53 protein]; MIR214 mRNA affects the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of TRP53 mRNA]]; TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to NOX4 promoter]]]; TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to SHC1 promoter]]]; TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of NOX4 mRNA]]; TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of SHC1 mRNA]] CTD PMID:26768586 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO ginkgolide B results in increased expression of UGT1A1 mRNA CTD PMID:19034627 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]] CTD PMID:26775663 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
Ginkgolide C term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]; KT 5823 inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]] CTD PMID:18001288 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]; KT 5823 inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]] CTD PMID:18001288 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:21329749 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
Ginkgolide J term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:21329749 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
Goe 6976 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions EXP Go 6976 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein] CTD PMID:18972403 PMID:20815017 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions EXP Go 6976 inhibits the reaction [2,4,6-tribromophenol results in decreased activity of ABCB1A protein] CTD PMID:31368499 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions EXP
ISO
Go 6976 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein] CTD PMID:18972403 PMID:20815017 PMID:29052767 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO Go 6976 results in decreased phosphorylation of AKT1 protein CTD PMID:19393235 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Go 6976 inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased secretion of APP protein modified form]; Go 6976 inhibits the reaction [Tretinoin results in increased secretion of APP protein modified form] CTD PMID:19476501 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO Go 6976 inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of ATF2 protein] CTD PMID:26763395 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 decreases activity EXP Go 6976 results in decreased activity of ATP2A2 protein CTD PMID:17003265 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
G Bace1 beta-secretase 1 multiple interactions ISO Go 6976 inhibits the reaction [Phorbol 12,13-Dibutyrate affects the localization of BACE1 protein] CTD PMID:19476501 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
JBrowse link
G Btg2 BTG anti-proliferation factor 2 multiple interactions ISO [Tetradecanoylphorbol Acetate co-treated with Go 6976] results in increased expression of BTG2 mRNA CTD PMID:15302583 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
JBrowse link
G Casp3 caspase 3 multiple interactions EXP Go 6976 inhibits the reaction [Ethanol results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:22497828 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO Go 6976 inhibits the reaction [Doxorubicin results in increased expression of CCNB1 protein] CTD PMID:17320279 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cdc25c cell division cycle 25C multiple interactions ISO Go 6976 inhibits the reaction [xanthatin results in decreased stability of CDC25C protein] CTD PMID:29074359 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdh2 cadherin 2 multiple interactions EXP Go 6976 inhibits the reaction [4-cresol affects the localization of CDH2 protein]; Go 6976 inhibits the reaction [4-cresol inhibits the reaction [CTNND1 protein binds to CDH2 protein]] CTD PMID:23466501 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO Go 6976 inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in decreased activity of CDK1 protein]; Go 6976 inhibits the reaction [xanthatin results in increased phosphorylation of CDK1 protein]; Go 6976 results in decreased phosphorylation of and results in increased activity of CDK1 protein CTD PMID:17320279 PMID:29074359 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Chek1 checkpoint kinase 1 decreases activity
multiple interactions
increases phosphorylation
ISO Go 6976 results in decreased activity of CHEK1 protein
xanthatin inhibits the reaction [Go 6976 results in increased phosphorylation of CHEK1 protein]
CTD PMID:10998351 PMID:20619533 PMID:29074359 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO Go 6976 inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of CHEK2 protein] CTD PMID:17320279 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit multiple interactions ISO Go 6976 inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; Go 6976 inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; Go 6976 inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 mRNA]; Go 6976 inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA5 protein] CTD PMID:18450646 NCBI chr 8:59,561,817...59,590,172
Ensembl chr 8:59,561,721...59,590,172
JBrowse link
G Crh corticotropin releasing hormone multiple interactions ISO CRH protein inhibits the reaction [Go 6976 results in increased abundance of Progesterone]; CRH protein inhibits the reaction [Go 6976 results in increased expression of CYP11A1 mRNA]; CRH protein inhibits the reaction [Go 6976 results in increased expression of HSD3B1 mRNA] CTD PMID:17170093 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Ctnnd1 catenin delta 1 multiple interactions EXP Go 6976 inhibits the reaction [4-cresol affects the localization of and results in decreased phosphorylation of CTNND1 protein]; Go 6976 inhibits the reaction [4-cresol inhibits the reaction [CTNND1 protein binds to CDH2 protein]] CTD PMID:23466501 NCBI chr 3:72,001,904...72,053,047
Ensembl chr 3:72,002,152...72,053,049
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO CRH protein inhibits the reaction [Go 6976 results in increased expression of CYP11A1 mRNA] CTD PMID:17170093 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Egf epidermal growth factor multiple interactions EXP Go 6976 inhibits the reaction [EGF protein binds to and results in increased localization of EGFR protein] CTD PMID:11134345 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO
EXP
Go 6976 inhibits the reaction [irinotecan metabolite results in increased phosphorylation of EGFR protein]; Go 6976 inhibits the reaction [irinotecan results in increased phosphorylation of EGFR protein]
Go 6976 inhibits the reaction [EGF protein binds to and results in increased localization of EGFR protein]
CTD PMID:11134345 PMID:15723263 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Elavl1 ELAV like RNA binding protein 1 multiple interactions ISO Go 6976 inhibits the reaction [N-Methylaspartate results in increased phosphorylation of ELAVL1 protein] CTD PMID:31945382 NCBI chr12:2,461,502...2,502,432
Ensembl chr12:2,461,502...2,502,432
JBrowse link
G Gap43 growth associated protein 43 multiple interactions ISO Go 6976 inhibits the reaction [isophthalate analog results in increased expression of GAP43 protein] CTD PMID:23643828 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914
JBrowse link
G Grp gastrin releasing peptide multiple interactions ISO Go 6976 promotes the reaction [GRP protein modified form results in increased chemical synthesis of Inositol Phosphates] CTD PMID:18313772 NCBI chr18:61,563,458...61,576,818
Ensembl chr18:61,563,053...61,576,818
JBrowse link
G Hdac5 histone deacetylase 5 multiple interactions ISO Go 6976 inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased activity of PRKD1 protein] which affects the localization of HDAC5 protein] CTD PMID:19124542 NCBI chr10:90,140,183...90,169,853
Ensembl chr10:90,140,183...90,151,042
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Go 6976 inhibits the reaction [Curcumin results in increased expression of HMOX1 protein] CTD PMID:18357586 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO Go 6976 inhibits the reaction [lead acetate results in increased activity of HRAS protein] CTD PMID:19133285 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions
increases expression
ISO CRH protein inhibits the reaction [Go 6976 results in increased expression of HSD3B1 mRNA] CTD PMID:17170093
G Htr2a 5-hydroxytryptamine receptor 2A increases expression EXP Go 6976 results in increased expression of HTR2A mRNA CTD PMID:22791651 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Go 6976 inhibits the reaction [IL1A protein results in increased secretion of IL6 protein] CTD PMID:16532021 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Go 6976 inhibits the reaction [IL1B protein affects the localization of NCF1 protein]; Go 6976 inhibits the reaction [IL1B protein results in increased abundance of Reactive Oxygen Species]; Go 6976 inhibits the reaction [IL1B protein results in increased expression of VCAM1 mRNA]; Go 6976 inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; Go 6976 inhibits the reaction [IL1B protein results in increased phosphorylation of SRC protein] CTD PMID:19281832 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions ISO Go 6976 inhibits the reaction [pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]] CTD PMID:16241859 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Go 6976 inhibits the reaction [IL1A protein results in increased secretion of IL6 protein]; Go 6976 inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of IL6 mRNA] CTD PMID:16532021 PMID:26763395 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jak2 Janus kinase 2 multiple interactions EXP
ISO
Go 6976 results in decreased phosphorylation of and results in decreased activity of JAK2 protein CTD PMID:15746188 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Go 6976 inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of JUN protein] CTD PMID:20152819 PMID:21354279 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO
EXP
Go 6976 inhibits the reaction [[cholix toxin, Vibrio cholerae co-treated with TNF protein] results in increased phosphorylation of MAPK1 protein]; Go 6976 inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Go 6976 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
Go 6976 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MAPK1 protein]
Go 6976 results in decreased phosphorylation of MAPK1 protein
CTD PMID:12720544 PMID:14511371 PMID:16251475 PMID:19393235 PMID:20152819 PMID:21354279 PMID:28087840 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO
EXP
Go 6976 inhibits the reaction [[cholix toxin, Vibrio cholerae co-treated with TNF protein] results in increased phosphorylation of MAPK3 protein]; Go 6976 inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Go 6976 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
Go 6976 results in decreased phosphorylation of MAPK3 protein
Go 6976 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MAPK3 protein]; Go 6976 inhibits the reaction [zinc chloride results in increased phosphorylation of MAPK3 protein]
CTD PMID:12720544 PMID:14511371 PMID:16251475 PMID:19393235 PMID:20152819 PMID:21354279 PMID:21575692 PMID:28087840 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Go 6976 inhibits the reaction [[cholix toxin, Vibrio cholerae co-treated with TNF protein] results in increased phosphorylation of MAPK8 protein] CTD PMID:28087840 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mef2c myocyte enhancer factor 2C multiple interactions ISO Go 6976 inhibits the reaction [Phenylephrine results in increased activity of MEF2C protein] CTD PMID:19124542 NCBI chr 2:11,658,534...11,822,788
Ensembl chr 2:11,658,568...11,822,787
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Go 6976 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]; Go 6976 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; Go 6976 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]; Go 6976 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of and results in increased activity of MMP9 protein]; Go 6976 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein] CTD PMID:19804834 PMID:20152819 PMID:21354279 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO
EXP
Go 6976 inhibits the reaction [IL1B protein affects the localization of NCF1 protein]
Go 6976 inhibits the reaction [Ethanol affects the localization of NCF1 protein]
CTD PMID:19281832 PMID:22497828 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Ngf nerve growth factor multiple interactions EXP Go 6976 inhibits the reaction [NGF protein results in increased expression of SERPINE1 mRNA]; Go 6976 inhibits the reaction [NGF protein results in increased expression of SERPINE1 protein] CTD PMID:23825664 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nts neurotensin multiple interactions
increases activity
ISO Go 6976 inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein]; Go 6976 promotes the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates]; Tetradecanoylphorbol Acetate inhibits the reaction [Go 6976 results in increased activity of NTS protein] CTD PMID:18313772 NCBI chr 7:44,111,594...44,120,998
Ensembl chr 7:44,111,151...44,121,130
JBrowse link
G P2ry2 purinergic receptor P2Y2 multiple interactions EXP Go 6976 promotes the reaction [P2RY2 protein results in increased uptake of Calcium] CTD PMID:17003265 NCBI chr 1:166,031,228...166,045,423
Ensembl chr 1:166,031,272...166,037,424
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Go 6976 inhibits the reaction [[cholix toxin, Vibrio cholerae co-treated with TNF protein] results in increased cleavage of PARP1 protein] CTD PMID:28087840 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 decreases activity ISO Go 6976 results in decreased activity of PDPK1 protein CTD PMID:10998351 NCBI chr10:13,446,373...13,525,248
Ensembl chr10:13,451,624...13,515,448
JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO Go 6976 inhibits the reaction [Zinc results in increased expression of PLAT mRNA]; Go 6976 inhibits the reaction [Zinc results in increased expression of PLAT protein] CTD PMID:21615740 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Pld1 phospholipase D1 multiple interactions EXP
ISO
Go 6976 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of PLD1 protein]
Go 6976 inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of PLD1 mRNA]; Go 6976 inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of PLD1 protein]
CTD PMID:15150437 PMID:26763395 NCBI chr 2:113,651,967...113,849,403
Ensembl chr 2:113,652,348...113,849,403
JBrowse link
G Pld2 phospholipase D2 multiple interactions ISO Go 6976 inhibits the reaction [PLD2 protein promotes the reaction [epigallocatechin gallate results in increased expression of PTGS2 protein]] CTD PMID:15210717 NCBI chr10:57,161,921...57,181,148
Ensembl chr10:57,163,174...57,179,730
JBrowse link
G Plg plasminogen multiple interactions ISO Go 6976 inhibits the reaction [Zinc results in increased expression of PLG mRNA]; Go 6976 inhibits the reaction [Zinc results in increased expression of PLG protein] CTD PMID:21615740 NCBI chr 1:48,521,828...48,563,895
Ensembl chr 1:48,521,772...48,563,776
JBrowse link
G Prkca protein kinase C, alpha decreases expression
multiple interactions
decreases phosphorylation
ISO
EXP
Go 6976 results in decreased expression of PRKCA mRNA
Go 6976 inhibits the reaction [isophthalate analog affects the localization of PRKCA protein]; Go 6976 results in decreased expression of and results in decreased activity of PRKCA protein
Go 6976 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of PRKCA protein]
Go 6976 results in decreased phosphorylation of PRKCA protein
CTD PMID:16374459 PMID:18972403 PMID:19393235 PMID:23643828 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Prkd1 protein kinase D1 multiple interactions ISO Go 6976 inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased activity of PRKD1 protein] which affects the localization of HDAC5 protein] CTD PMID:19124542 NCBI chr 6:71,035,017...71,349,531
Ensembl chr 6:71,035,332...71,349,249
JBrowse link
G Psen1 presenilin 1 multiple interactions ISO Go 6976 inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased expression of PSEN1 protein]; Go 6976 inhibits the reaction [Tretinoin results in increased expression of PSEN1 protein] CTD PMID:19476501 NCBI chr 6:107,169,514...107,221,000
Ensembl chr 6:107,169,528...107,216,798
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO
Go 6976 inhibits the reaction [epigallocatechin gallate results in increased expression of PTGS2 protein]
Go 6976 inhibits the reaction [epigallocatechin gallate results in increased expression of PTGS2 protein]; Go 6976 inhibits the reaction [PLD2 protein promotes the reaction [epigallocatechin gallate results in increased expression of PTGS2 protein]]; Go 6976 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
CTD PMID:15210717 PMID:19804834 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions EXP Go 6976 inhibits the reaction [zinc chloride results in increased phosphorylation of RAF1 protein] CTD PMID:21575692 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Go 6976 inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of RELA protein] CTD PMID:20152819 PMID:21354279 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sct secretin multiple interactions EXP Go 6976 inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid analog]; Go 6976 inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid]; Go 6976 inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT] CTD PMID:22194894 NCBI chr 1:214,264,865...214,277,437
Ensembl chr 1:214,264,754...214,265,668
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP Go 6976 inhibits the reaction [NGF protein results in increased expression of SERPINE1 mRNA]; Go 6976 inhibits the reaction [NGF protein results in increased expression of SERPINE1 protein] CTD PMID:23825664 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Shc1 SHC adaptor protein 1 multiple interactions EXP Go 6976 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of SHC1 protein alternative form] CTD PMID:19168439 NCBI chr 2:188,745,503...188,757,066
Ensembl chr 2:188,745,503...188,757,066
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO Go 6976 inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; Go 6976 inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA] CTD PMID:31945382 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Go 6976 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SOD2 mRNA]; Go 6976 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SOD2 protein] CTD PMID:21705328 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO Go 6976 inhibits the reaction [IL1B protein results in increased phosphorylation of SRC protein] CTD PMID:19281832 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions ISO
EXP
Go 6976 results in decreased phosphorylation of and results in decreased activity of STAT5A protein CTD PMID:15746188 NCBI chr10:88,764,732...88,789,060
Ensembl chr10:88,764,732...88,789,057
JBrowse link
G Sts steroid sulfatase multiple interactions ISO Go 6976 inhibits the reaction [Tretinoin results in increased activity of STS protein] CTD PMID:16178010 NCBI chr  X:45,420,418...45,428,748
Ensembl chr  X:45,420,596...45,428,750
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP Go 6976 inhibits the reaction [GR 73632 promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]] CTD PMID:18809416 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tff1 trefoil factor 1 multiple interactions ISO Go 6976 inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [benz(a)anthracene results in increased expression of TFF1 mRNA]] CTD PMID:22643241 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions EXP Go 6976 inhibits the reaction [tert-Butylhydroperoxide affects the localization of TJP1 protein] CTD PMID:16716901 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Go 6976 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Go 6976 inhibits the reaction [[cholix toxin, Vibrio cholerae co-treated with TNF protein] results in increased cleavage of PARP1 protein]; Go 6976 inhibits the reaction [[cholix toxin, Vibrio cholerae co-treated with TNF protein] results in increased phosphorylation of MAPK1 protein]; Go 6976 inhibits the reaction [[cholix toxin, Vibrio cholerae co-treated with TNF protein] results in increased phosphorylation of MAPK3 protein]; Go 6976 inhibits the reaction [[cholix toxin, Vibrio cholerae co-treated with TNF protein] results in increased phosphorylation of MAPK8 protein]
CTD PMID:22102721 PMID:28087840 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP Go 6976 inhibits the reaction [GR 73632 results in increased phosphorylation of TRPV1 protein] CTD PMID:18809416 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Ulbp1 UL16 binding protein 1 increases expression ISO Go 6976 results in increased expression of ULBP1 mRNA CTD PMID:21951556 NCBI chr 1:1,181,301...1,200,526
Ensembl chr 1:1,180,932...1,220,916
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Go 6976 inhibits the reaction [IL1B protein results in increased expression of VCAM1 mRNA]; Go 6976 inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] CTD PMID:19281832 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vdr vitamin D receptor multiple interactions ISO Go 6976 inhibits the reaction [isopentenyl pyrophosphate results in increased expression of VDR protein]
Go 6976 inhibits the reaction [1,25-dihydroxyvitamin D results in increased activity of VDR protein]
CTD PMID:15879110 PMID:18829283 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Go 6976 inhibits the reaction [[Ethanol co-treated with sodium arsenite] results in increased expression of VEGFA mRNA] CTD PMID:18210215 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
icajine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn5a sodium voltage-gated channel alpha subunit 5 multiple interactions ISO icajine binds to and results in decreased activity of SCN5A protein CTD PMID:21616062 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link
limonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression
multiple interactions
ISO limonin results in decreased expression of ALDH1A1 mRNA
limonin results in decreased expression of and results in decreased activity of ALDH1A1 protein
CTD PMID:30738134 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Casp3 caspase 3 increases activity ISO limonin results in increased activity of CASP3 protein CTD PMID:31702096 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases activity ISO limonin results in increased activity of CASP9 protein CTD PMID:31702096 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions ISO limonin inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein] CTD PMID:31702096 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression ISO limonin results in decreased expression of CCN2 mRNA CTD PMID:30738134 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Cdh1 cadherin 1 increases expression ISO limonin results in increased expression of CDH1 mRNA; limonin results in increased expression of CDH1 protein CTD PMID:30738134 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Ephx2 epoxide hydrolase 2 multiple interactions ISO limonin inhibits the reaction [EPHX2 protein results in increased metabolism of stilbene oxide analog] CTD PMID:2043152 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO limonin inhibits the reaction [Benzo(a)pyrene results in decreased activity of GSR protein] CTD PMID:31702096 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO limonin inhibits the reaction [Benzo(a)pyrene results in increased activity of IL1B protein] CTD PMID:31702096 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Nanog Nanog homeobox decreases expression ISO limonin results in decreased expression of NANOG mRNA; limonin results in decreased expression of NANOG protein CTD PMID:30738134 NCBI chr 4:155,531,906...155,539,268
Ensembl chr 4:155,531,906...155,539,268
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO limonin inhibits the reaction [Benzo(a)pyrene results in increased activity of TNF protein] CTD PMID:31702096 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vim vimentin decreases expression ISO limonin results in decreased expression of VIM mRNA; limonin results in decreased expression of VIM protein CTD PMID:30738134 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Yap1 Yes1 associated transcriptional regulator affects localization ISO limonin affects the localization of YAP1 protein CTD PMID:30738134 NCBI chr 8:6,133,014...6,204,240
Ensembl chr 8:6,135,493...6,203,579
JBrowse link
rifaximin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of ABCB1A mRNA
rifaximin results in increased expression of ABCB1 mRNA
CTD PMID:21141967 PMID:22790967 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of ACTA2 mRNA CTD PMID:22790967 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Apoa4 apolipoprotein A4 multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of APOA4 mRNA CTD PMID:22790967 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO [rifaximin binds to and results in increased activity of NR1I2 protein] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CCL3 protein]; rifaximin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CCL3 protein] CTD PMID:21599020 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of CD36 protein CTD PMID:22790967 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cfd complement factor D multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of CFD mRNA CTD PMID:22790967 NCBI chr 7:12,634,216...12,635,939
Ensembl chr 7:12,634,216...12,635,943
JBrowse link
G Cidec cell death-inducing DFFA-like effector c multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of CIDEC mRNA CTD PMID:22790967 NCBI chr 4:145,377,482...145,390,497
Ensembl chr 4:145,377,431...145,390,497
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of COL1A1 mRNA CTD PMID:22790967 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of CYP3A11 mRNA CTD PMID:22790967 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of CYP7A1 protein CTD PMID:22790967 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of CYP7B1 protein CTD PMID:22790967 NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257
JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of DGAT2 mRNA CTD PMID:22790967 NCBI chr 1:164,113,459...164,143,818
Ensembl chr 1:164,113,459...164,143,818
JBrowse link
G Fabp2 fatty acid binding protein 2 multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of FABP2 protein CTD PMID:22790967 NCBI chr 2:227,080,912...227,083,654
Ensembl chr 2:227,080,924...227,083,501
JBrowse link
G Ifng interferon gamma multiple interactions ISO [rifaximin binds to and results in increased activity of NR1I2 protein] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IFNG protein]; rifaximin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IFNG protein] CTD PMID:21599020 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [rifaximin co-treated with Trinitrobenzenesulfonic Acid] results in increased expression of IL10 protein CTD PMID:21599020 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Lta lymphotoxin alpha multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of LTA mRNA CTD PMID:22790967 NCBI chr20:4,851,889...4,854,677
Ensembl chr20:4,852,496...4,854,677
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [rifaximin binds to and results in increased activity of NR1I2 protein] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MPO protein]; rifaximin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MPO protein] CTD PMID:21599020 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of NR1H4 protein CTD PMID:22790967 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
increases expression
increases response to substance
ISO 4,4'-hexafluorisopropylidene diphenol inhibits the reaction [Rifaximin results in increased activity of NR1I2 protein]; 4,4'-hexafluorisopropylidene diphenol metabolite inhibits the reaction [Rifaximin results in increased activity of NR1I2 protein]; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased abundance of Triglycerides; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of ABCB1A mRNA; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of ACTA2 mRNA; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of APOA4 mRNA; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of CD36 protein; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of CFD mRNA; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of CIDEC mRNA; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of COL1A1 mRNA; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of CYP3A11 mRNA; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of CYP7A1 protein; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of CYP7B1 protein; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of DGAT2 mRNA; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of FABP2 protein; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of LTA mRNA; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of NR1H4 protein; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of PPARG mRNA; [Rifaximin binds to and results in increased activity of NR1I2 protein] which results in decreased susceptibility to Trinitrobenzenesulfonic Acid; bis(2-ethylhexyl) 2,3,4,5-tetrabromophthalate inhibits the reaction [Rifaximin results in increased activity of NR1I2 protein]; Rifaximin binds to and results in increased activity of NR1I2 protein
[Rifaximin binds to and results in increased activity of NR1I2 protein] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CCL3 protein]; [Rifaximin binds to and results in increased activity of NR1I2 protein] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IFNG protein]; [Rifaximin binds to and results in increased activity of NR1I2 protein] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MPO protein]; [Rifaximin binds to and results in increased activity of NR1I2 protein] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]
rifaximin results in increased expression of NR1I2 mRNA
NR1I2 results in increased susceptibility to rifaximin
CTD PMID:21599020 PMID:22291955 PMID:22790967 PMID:27506419 PMID:30408883 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of PPARG mRNA CTD PMID:22790967 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [rifaximin co-treated with Trinitrobenzenesulfonic Acid] results in increased expression of TGFB1 protein CTD PMID:21599020 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [rifaximin binds to and results in increased activity of NR1I2 protein] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; rifaximin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein] CTD PMID:21599020 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
solanidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase decreases activity ISO solanidine results in decreased activity of BCHE protein CTD PMID:31152736 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19781
    chemical entity 19781
      atom 19779
        nonmetal atom 19659
          carbon atom 19578
            organic molecular entity 19578
              heteroorganic entity 19216
                organic heterocyclic compound 18550
                  organic heteropolycyclic compound 18038
                    organic heterohexacyclic compound 125
                      (25R)-5beta-spirostan-3beta-ol + 0
                      (S)-cis-N-methylstylopine 0
                      (S)-stylopine + 0
                      10-hydroxyicajine 0
                      11,12-epoxy-3-methylcholanthrene 0
                      11-hydroxyicajine 0
                      12-O-deacetyltrichilin H 0
                      14-hydroxyicajine 0
                      19-O-acetylhoerhammericine 0
                      23-acetoxysoladulcidine 0
                      4'-demethylrebeccamycin 0
                      5-hydroxyvomicine 0
                      7-methoxydeoxymorellin 0
                      8,8a-epoxymorellic acid 0
                      BE-24566B 0
                      BE-54238B 0
                      GW296115X 0
                      Goe 6976 74
                      JP-8g 0
                      Ys-II 0
                      Ys-IV 0
                      agigenin + 0
                      ajaconine 0
                      alisiaquninone C 0
                      ambiguine I 0
                      aranotin 0
                      atisine 0
                      bielschowskysin 0
                      caracurine VII 2
                      cassameridine 0
                      celastolide 0
                      cercosporin 0
                      citrinalin B 0
                      cladoniamide A 0
                      cladoniamide B 0
                      cladoniamide C 0
                      corynoline 0
                      dichloroarcyriaflavin A 0
                      elaeodendroside B 0
                      elaeodendroside F 0
                      elaeodendroside G 0
                      elaeodendroside T 0
                      erdasporine A 0
                      erdasporine B + 0
                      erdasporine C 0
                      fumitremorgin A 0
                      ginkgolide + 31
                      gnidilatimonoein 0
                      hallactone B 0
                      hernandonine 0
                      hoerhammericine + 0
                      icajine 1
                      inumakilactone 0
                      inumakilactone B 0
                      isobrucine 0
                      isobrucine N-oxide 0
                      isopseudostrychnine 0
                      isostrychnine 0
                      isostrychnine N-oxide 0
                      jerantinine B 0
                      jerantinine D 0
                      jerantinine F 0
                      lactonamycin 0
                      limonin + 13
                      lochnericine 0
                      maackiapterocarpan A 0
                      mannioside A 0
                      morellic acid + 0
                      morellin + 0
                      nogalamycin 0
                      notoamide D 0
                      novacine 0
                      oxazine-750 0
                      pennogenin + 0
                      protostrychnine 0
                      rauvomitine 0
                      rebeccamycin 0
                      rifaximin 22
                      rostratin A 0
                      rostratin B 0
                      rostratin C 0
                      rostratin D 0
                      solanidine + 1
                      solanine 0
                      trigoheterin E, (rel)- 0
                      verruculogen + 0
                      yuccalan 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19781
    subatomic particle 19779
      composite particle 19779
        hadron 19779
          baryon 19779
            nucleon 19779
              atomic nucleus 19779
                atom 19779
                  main group element atom 19669
                    p-block element atom 19669
                      carbon group element atom 19588
                        carbon atom 19578
                          organic molecular entity 19578
                            organic molecule 19510
                              organic cyclic compound 19337
                                organic heterocyclic compound 18550
                                  organic heteropolycyclic compound 18038
                                    organic heterohexacyclic compound 125
                                      (25R)-5beta-spirostan-3beta-ol + 0
                                      (S)-cis-N-methylstylopine 0
                                      (S)-stylopine + 0
                                      10-hydroxyicajine 0
                                      11,12-epoxy-3-methylcholanthrene 0
                                      11-hydroxyicajine 0
                                      12-O-deacetyltrichilin H 0
                                      14-hydroxyicajine 0
                                      19-O-acetylhoerhammericine 0
                                      23-acetoxysoladulcidine 0
                                      4'-demethylrebeccamycin 0
                                      5-hydroxyvomicine 0
                                      7-methoxydeoxymorellin 0
                                      8,8a-epoxymorellic acid 0
                                      BE-24566B 0
                                      BE-54238B 0
                                      GW296115X 0
                                      Goe 6976 74
                                      JP-8g 0
                                      Ys-II 0
                                      Ys-IV 0
                                      agigenin + 0
                                      ajaconine 0
                                      alisiaquninone C 0
                                      ambiguine I 0
                                      aranotin 0
                                      atisine 0
                                      bielschowskysin 0
                                      caracurine VII 2
                                      cassameridine 0
                                      celastolide 0
                                      cercosporin 0
                                      citrinalin B 0
                                      cladoniamide A 0
                                      cladoniamide B 0
                                      cladoniamide C 0
                                      corynoline 0
                                      dichloroarcyriaflavin A 0
                                      elaeodendroside B 0
                                      elaeodendroside F 0
                                      elaeodendroside G 0
                                      elaeodendroside T 0
                                      erdasporine A 0
                                      erdasporine B + 0
                                      erdasporine C 0
                                      fumitremorgin A 0
                                      ginkgolide + 31
                                      gnidilatimonoein 0
                                      hallactone B 0
                                      hernandonine 0
                                      hoerhammericine + 0
                                      icajine 1
                                      inumakilactone 0
                                      inumakilactone B 0
                                      isobrucine 0
                                      isobrucine N-oxide 0
                                      isopseudostrychnine 0
                                      isostrychnine 0
                                      isostrychnine N-oxide 0
                                      jerantinine B 0
                                      jerantinine D 0
                                      jerantinine F 0
                                      lactonamycin 0
                                      limonin + 13
                                      lochnericine 0
                                      maackiapterocarpan A 0
                                      mannioside A 0
                                      morellic acid + 0
                                      morellin + 0
                                      nogalamycin 0
                                      notoamide D 0
                                      novacine 0
                                      oxazine-750 0
                                      pennogenin + 0
                                      protostrychnine 0
                                      rauvomitine 0
                                      rebeccamycin 0
                                      rifaximin 22
                                      rostratin A 0
                                      rostratin B 0
                                      rostratin C 0
                                      rostratin D 0
                                      solanidine + 1
                                      solanine 0
                                      trigoheterin E, (rel)- 0
                                      verruculogen + 0
                                      yuccalan 0
paths to the root