Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:methyl ketone
go back to main search page
Accession:CHEBI:51867 term browser browse the term
Definition:A ketone of formula RC(=O)CH3 (R =/= H).
Synonyms:related_synonym: methyl ketones



show annotations for term's descendants           Sort by:
(R)-acetoin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B increases reduction
multiple interactions
ISO AKR1B1 protein results in increased reduction of Acetoin
[AKR1B1 protein results in increased reduction of Acetoin] which results in increased chemical synthesis of 2,3-butylene glycol; [AKR1B1 protein results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin
CTD PMID:23295224 NCBI chr 6:34,280,865...34,294,424
Ensembl chr 6:34,279,369...34,294,413
JBrowse link
G Akr1b10 aldo-keto reductase family 1, member B10 increases reduction
multiple interactions
ISO AKR1B10 protein results in increased reduction of Acetoin
[AKR1B10 protein results in increased reduction of Acetoin] which results in increased chemical synthesis of 2,3-butylene glycol; [AKR1B10 protein results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin
CTD PMID:23295224 NCBI chr 6:34,361,182...34,373,884
Ensembl chr 6:34,361,153...34,373,885
JBrowse link
G Dcxr dicarbonyl L-xylulose reductase multiple interactions ISO 1,2-naphthoquinone inhibits the reaction [[[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin]; 1,4-naphthoquinone inhibits the reaction [[[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin]; 9,10-phenanthrenequinone inhibits the reaction [[[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin]; [[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin; [DCXR protein co-treated with NAD] results in increased chemical synthesis of Acetoin; Vitamin K 3 inhibits the reaction [[[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin] CTD PMID:28595002 NCBI chr11:120,615,372...120,618,110
Ensembl chr11:120,616,225...120,618,107
JBrowse link
2',4',6'-trihydroxyacetophenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpt glutamic pyruvic transaminase, soluble multiple interactions EXP 2,4,6-trihydroxyacetophenone inhibits the reaction [Acetaminophen results in increased activity of GPT protein] CTD PMID:30287234 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
JBrowse link
2,5-hexanedione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 5031439G07Rik RIKEN cDNA 5031439G07 gene increases expression ISO 2,5-hexanedione results in increased expression of KIAA0930 mRNA CTD PMID:22952946 NCBI chr15:84,828,137...84,872,503
Ensembl chr15:84,828,137...84,872,752
JBrowse link
G Abi2 abl interactor 2 increases expression ISO 2,5-hexanedione results in increased expression of ABI2 mRNA CTD PMID:22952946 PMID:27466211 NCBI chr 1:60,444,927...60,521,104
Ensembl chr 1:60,448,778...60,520,317
JBrowse link
G Aco2 aconitase 2, mitochondrial increases expression ISO 2,5-hexanedione results in increased expression of ACO2 protein CTD PMID:19033394 NCBI chr15:81,756,664...81,799,338
Ensembl chr15:81,756,510...81,799,334
JBrowse link
G Aif1 allograft inflammatory factor 1 increases expression
multiple interactions
ISO 2,5-hexanedione results in increased expression of AIF1 protein
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of AIF1 protein]
CTD PMID:32522579 PMID:32860822 NCBI chr17:35,389,967...35,394,977
Ensembl chr17:35,389,967...35,395,044
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 decreases phosphorylation
increases expression
EXP 2,5-hexanedione results in decreased phosphorylation of AKT1 protein
2,5-hexanedione results in increased expression of AKT1 mRNA
CTD PMID:33197454 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Alox8 arachidonate 8-lipoxygenase decreases expression ISO 2,5-hexanedione results in decreased expression of ALOX15B mRNA CTD PMID:22952946 NCBI chr11:69,074,711...69,088,669
Ensembl chr11:69,074,758...69,088,669
JBrowse link
G Angptl4 angiopoietin-like 4 affects expression ISO 2,5-hexanedione affects the expression of ANGPTL4 mRNA CTD PMID:20616210 NCBI chr17:33,993,874...34,000,549
Ensembl chr17:33,992,724...34,000,804
JBrowse link
G Arg1 arginase, liver decreases expression
multiple interactions
ISO 2,5-hexanedione results in decreased expression of ARG1 mRNA
Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of ARG1 mRNA]
CTD PMID:32522579 PMID:32860822 NCBI chr10:24,791,105...24,803,368
Ensembl chr10:24,791,119...24,803,382
JBrowse link
G AW554918 expressed sequence AW554918 increases expression ISO 2,5-hexanedione results in increased expression of KIAA1328 mRNA CTD PMID:22952946 NCBI chr18:25,301,825...25,600,378
Ensembl chr18:25,302,056...25,600,378
JBrowse link
G Bax BCL2-associated X protein increases expression ISO 2,5-hexanedione results in increased expression of BAX mRNA; 2,5-hexanedione results in increased expression of BAX protein CTD PMID:17492505 PMID:21901545 PMID:22337490 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 increases expression
decreases expression
ISO 2,5-hexanedione results in increased expression of BCL2 protein
2,5-hexanedione results in decreased expression of BCL2 mRNA
2,5-hexanedione results in decreased expression of BCL2 mRNA; 2,5-hexanedione results in decreased expression of BCL2 protein
CTD PMID:17492505 PMID:21901545 PMID:22337490 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bcl2l14 BCL2 like 14 increases expression ISO 2,5-hexanedione results in increased expression of BCL2L14 mRNA CTD PMID:22952946 NCBI chr 6:134,373,292...134,415,687
Ensembl chr 6:134,373,281...134,415,699
JBrowse link
G Bdnf brain derived neurotrophic factor decreases expression ISO 2,5-hexanedione results in decreased expression of BDNF protein CTD PMID:31760062 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352
JBrowse link
G Bfar bifunctional apoptosis regulator increases expression ISO 2,5-hexanedione results in increased expression of BFAR mRNA CTD PMID:22952946 NCBI chr16:13,489,722...13,521,476
Ensembl chr16:13,489,722...13,521,476
Ensembl chr16:13,489,722...13,521,476
JBrowse link
G Casp1 caspase 1 multiple interactions
increases expression
increases cleavage
ISO Glyburide inhibits the reaction [2,5-hexanedione results in increased cleavage of CASP1 protein]
2,5-hexanedione results in increased expression of CASP1 mRNA
CTD PMID:32522579 PMID:32860822 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
JBrowse link
G Casp3 caspase 3 increases expression ISO 2,5-hexanedione results in increased expression of CASP3 mRNA; 2,5-hexanedione results in increased expression of CASP3 protein alternative form CTD PMID:17492505 PMID:21901545 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp8 caspase 8 decreases expression EXP 2,5-hexanedione results in decreased expression of CASP8 protein CTD PMID:33197454 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
JBrowse link
G Ccdc171 coiled-coil domain containing 171 increases expression ISO 2,5-hexanedione results in increased expression of CCDC171 mRNA CTD PMID:22952946 NCBI chr 4:83,443,649...83,784,380
Ensembl chr 4:83,443,782...83,782,907
JBrowse link
G Ccdc191 coiled-coil domain containing 191 increases expression ISO 2,5-hexanedione results in increased expression of CCDC191 mRNA CTD PMID:22952946 NCBI chr16:43,710,172...43,784,677
Ensembl chr16:43,710,163...43,784,677
JBrowse link
G Cdin1 CDAN1 interacting nuclease 1 increases expression ISO 2,5-hexanedione results in increased expression of CDIN1 mRNA CTD PMID:22952946 NCBI chr 2:115,411,388...115,609,263
Ensembl chr 2:115,412,197...115,609,249
JBrowse link
G Cep112 centrosomal protein 112 increases expression ISO 2,5-hexanedione results in increased expression of CEP112 mRNA CTD PMID:22952946 NCBI chr11:108,316,041...108,751,441
Ensembl chr11:108,316,018...108,751,441
JBrowse link
G Cfap221 cilia and flagella associated protein 221 increases expression ISO 2,5-hexanedione results in increased expression of CFAP221 mRNA CTD PMID:22952946 NCBI chr 1:119,851,070...119,934,624
Ensembl chr 1:119,851,071...119,924,964
JBrowse link
G Ckmt1 creatine kinase, mitochondrial 1, ubiquitous increases expression ISO 2,5-hexanedione results in increased expression of CKMT1B protein CTD PMID:19033394 NCBI chr 2:121,188,257...121,194,218
Ensembl chr 2:121,188,195...121,194,218
JBrowse link
G Clca2 chloride channel accessory 2 multiple interactions ISO [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of CLCA2 mRNA CTD PMID:22382377 NCBI chr 3:144,776,021...144,805,204
Ensembl chr 3:144,776,024...144,805,204
JBrowse link
G Clu clusterin decreases expression
increases expression
ISO 2,5-hexanedione results in decreased expression of CLU mRNA
2,5-hexanedione results in increased expression of CLU mRNA
CTD PMID:22952946 PMID:27466211 NCBI chr14:66,206,093...66,218,992
Ensembl chr14:66,205,932...66,218,996
JBrowse link
G Ctxn1 cortexin 1 increases expression ISO 2,5-hexanedione results in increased expression of CTXN1 mRNA CTD PMID:22952946 NCBI chr 8:4,307,646...4,309,274
Ensembl chr 8:4,307,660...4,309,274
JBrowse link
G Dcn decorin increases expression ISO 2,5-hexanedione results in increased expression of DCN mRNA CTD PMID:22952946 NCBI chr10:97,315,362...97,354,025
Ensembl chr10:97,315,471...97,354,005
JBrowse link
G Dennd1a DENN domain containing 1A increases expression ISO 2,5-hexanedione results in increased expression of DENND1A mRNA CTD PMID:22952946 NCBI chr 2:37,689,002...38,177,417
Ensembl chr 2:37,689,003...38,177,402
JBrowse link
G Dicer1 dicer 1, ribonuclease type III increases expression EXP 2,5-hexanedione results in increased expression of DICER1 mRNA CTD PMID:33197454 NCBI chr12:104,654,001...104,718,331
Ensembl chr12:104,654,001...104,718,211
JBrowse link
G Dnaaf11 dynein axonemal assembly factor 11 increases expression ISO 2,5-hexanedione results in increased expression of DNAAF11 mRNA CTD PMID:22952946 NCBI chr15:66,251,707...66,372,769
Ensembl chr15:66,251,707...66,372,759
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO 2,5-hexanedione results in increased expression of DNAJB4 mRNA CTD PMID:22952946 NCBI chr 3:151,887,217...151,915,720
Ensembl chr 3:151,884,148...151,915,939
JBrowse link
G Dpp7 dipeptidylpeptidase 7 multiple interactions ISO [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of DPP7 mRNA CTD PMID:22382377 NCBI chr 2:25,242,302...25,246,365
Ensembl chr 2:25,242,288...25,246,371
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 decreases expression ISO 2,5-hexanedione results in decreased expression of DPYSL2 protein CTD PMID:19033394 NCBI chr14:67,040,313...67,148,490
Ensembl chr14:67,040,313...67,106,137
JBrowse link
G Egfr epidermal growth factor receptor increases expression ISO 2,5-hexanedione results in increased expression of EGFR mRNA CTD PMID:16141653 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158
JBrowse link
G Erc1 ELKS/RAB6-interacting/CAST family member 1 increases expression ISO 2,5-hexanedione results in increased expression of ERC1 mRNA CTD PMID:22952946 NCBI chr 6:119,547,757...119,830,985
Ensembl chr 6:119,547,757...119,825,128
JBrowse link
G Fasl Fas ligand increases expression ISO 2,5-hexanedione results in increased expression of FASLG mRNA CTD PMID:22337490 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064
JBrowse link
G Fasn fatty acid synthase decreases expression ISO 2,5-hexanedione results in decreased expression of FASN protein CTD PMID:19033394 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373
JBrowse link
G Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide increases expression ISO 2,5-hexanedione results in increased expression of FCER1G mRNA CTD PMID:22952946 NCBI chr 1:171,057,141...171,061,918
Ensembl chr 1:171,057,141...171,061,934
JBrowse link
G Foxo3 forkhead box O3 increases phosphorylation
decreases expression
EXP 2,5-hexanedione results in increased phosphorylation of FOXO3 protein
2,5-hexanedione results in decreased expression of FOXO3 mRNA
CTD PMID:33197454 NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha increases expression ISO 2,5-hexanedione results in increased expression of GADD45 mRNA CTD PMID:16141653 NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441
JBrowse link
G Gas2 growth arrest specific 2 increases expression ISO 2,5-hexanedione results in increased expression of GAS2 mRNA CTD PMID:22952946 NCBI chr 7:51,511,560...51,644,753
Ensembl chr 7:51,511,763...51,644,723
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression
increases expression
ISO 2,5-hexanedione results in decreased expression of GFAP protein
2,5-hexanedione results in increased expression of GFAP protein
CTD PMID:19033394 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738
JBrowse link
G Ghsr growth hormone secretagogue receptor affects expression ISO 2,5-hexanedione affects the expression of GHSR mRNA CTD PMID:20616210 NCBI chr 3:27,425,500...27,433,384
Ensembl chr 3:27,425,500...27,432,159
JBrowse link
G Glud1 glutamate dehydrogenase 1 increases expression ISO 2,5-hexanedione results in increased expression of GLUD1 protein CTD PMID:19033394 NCBI chr14:34,032,684...34,066,990
Ensembl chr14:34,032,684...34,067,222
JBrowse link
G Gsdmd gasdermin D increases cleavage
multiple interactions
ISO 2,5-hexanedione results in increased cleavage of GSDMD protein
Glyburide inhibits the reaction [2,5-hexanedione results in increased cleavage of GSDMD protein]
CTD PMID:32522579 PMID:32860822 NCBI chr15:75,733,990...75,739,257
Ensembl chr15:75,734,176...75,739,257
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression ISO 2,5-hexanedione results in decreased expression of GSK3B protein CTD PMID:31760062 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446
JBrowse link
G Gsn gelsolin decreases expression ISO 2,5-hexanedione results in decreased expression of GSN protein CTD PMID:19033394 NCBI chr 2:35,146,371...35,197,914
Ensembl chr 2:35,146,392...35,197,904
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 decreases expression ISO 2,5-hexanedione results in decreased expression of GSTP1 mRNA CTD PMID:16141653 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
JBrowse link
G Hdgfl1 HDGF like 1 decreases expression ISO 2,5-hexanedione results in decreased expression of HDGFL1 mRNA CTD PMID:22952946 NCBI chr13:26,952,155...26,954,148
Ensembl chr13:26,952,156...26,954,148
JBrowse link
G Hspa1b heat shock protein 1B increases expression ISO 2,5-hexanedione results in increased expression of HSPA1B mRNA CTD PMID:16141653 NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214
JBrowse link
G Ier3 immediate early response 3 affects expression ISO 2,5-hexanedione affects the expression of IER3 mRNA CTD PMID:20616210 NCBI chr17:36,132,605...36,133,803
Ensembl chr17:36,132,576...36,133,815
JBrowse link
G Ift81 intraflagellar transport 81 increases expression ISO 2,5-hexanedione results in increased expression of IFT81 mRNA CTD PMID:22952946 NCBI chr 5:122,678,328...122,752,614
Ensembl chr 5:122,688,267...122,752,581
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 decreases expression ISO 2,5-hexanedione results in decreased expression of IGFBP3 mRNA CTD PMID:16141653 NCBI chr11:7,156,086...7,165,498
Ensembl chr11:7,156,086...7,163,923
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
ISO 2,5-hexanedione results in increased expression of IL1B mRNA; 2,5-hexanedione results in increased expression of IL1B protein
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of IL1B protein]
CTD PMID:16141653 PMID:32522579 PMID:32860822 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Ina internexin neuronal intermediate filament protein, alpha decreases expression ISO 2,5-hexanedione results in decreased expression of INA protein CTD PMID:19033394 NCBI chr19:47,003,120...47,013,766
Ensembl chr19:47,003,137...47,013,766
JBrowse link
G Itgam integrin alpha M increases expression
multiple interactions
EXP
ISO
2,5-hexanedione results in increased expression of ITGAM protein
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of ITGAM protein]
CTD PMID:19464574 PMID:32522579 PMID:32860822 NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663
JBrowse link
G Itgb1 integrin beta 1 (fibronectin receptor beta) decreases expression ISO 2,5-hexanedione results in decreased expression of ITGB1 mRNA CTD PMID:16141653 NCBI chr 8:129,412,135...129,460,060
Ensembl chr 8:129,412,135...129,459,681
JBrowse link
G Kif6 kinesin family member 6 increases expression ISO 2,5-hexanedione results in increased expression of KIF6 mRNA CTD PMID:22952946 NCBI chr17:49,922,121...50,216,875
Ensembl chr17:49,922,164...50,216,875
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression
multiple interactions
ISO 2,5-hexanedione results in decreased expression of KIT protein
resveratrol inhibits the reaction [2,5-hexanedione results in decreased expression of KIT protein]
CTD PMID:17725299 NCBI chr 5:75,735,647...75,817,382
Ensembl chr 5:75,735,576...75,817,382
JBrowse link
G Loxl1 lysyl oxidase-like 1 increases expression
multiple interactions
ISO 2,5-hexanedione results in increased expression of LOXL1 protein
2,5-hexanedione promotes the reaction [carbendazim results in increased expression of LOXL1 protein]; [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of LOXL1 mRNA
CTD PMID:22382377 NCBI chr 9:58,195,006...58,220,495
Ensembl chr 9:58,195,021...58,220,469
JBrowse link
G Lrrc69 leucine rich repeat containing 69 increases expression ISO 2,5-hexanedione results in increased expression of LRRC69 mRNA CTD PMID:22952946 NCBI chr 4:14,623,622...14,808,379
Ensembl chr 4:14,623,620...14,796,060
JBrowse link
G Lyz2 lysozyme 2 decreases expression
increases expression
ISO 2,5-hexanedione results in decreased expression of LYZ2 mRNA
2,5-hexanedione results in increased expression of LYZ2 mRNA
CTD PMID:22952946 NCBI chr10:117,113,446...117,118,177
Ensembl chr10:117,113,236...117,118,226
JBrowse link
G Macrod1 mono-ADP ribosylhydrolase 1 increases expression
multiple interactions
ISO 2,5-hexanedione results in increased expression of MACROD1 mRNA
[carbendazim co-treated with 2,5-hexanedione] results in decreased expression of MACROD1 mRNA
CTD PMID:22382377 NCBI chr19:7,034,065...7,175,427
Ensembl chr19:7,034,178...7,175,422
JBrowse link
G Map1a microtubule-associated protein 1 A decreases expression ISO 2,5-hexanedione results in decreased expression of MAP1A protein CTD PMID:20554699 NCBI chr 2:121,119,608...121,141,313
Ensembl chr 2:121,120,081...121,141,313
JBrowse link
G Map1b microtubule-associated protein 1B decreases expression ISO 2,5-hexanedione results in decreased expression of MAP1B protein; 2,5-hexanedione results in decreased expression of MAP1B protein modified form CTD PMID:20554699 PMID:31760062 NCBI chr13:99,557,972...99,653,110
Ensembl chr13:99,557,954...99,653,048
JBrowse link
G Map2 microtubule-associated protein 2 decreases expression ISO 2,5-hexanedione results in decreased expression of MAP2 protein modified form CTD PMID:20554699 NCBI chr 1:66,214,337...66,481,742
Ensembl chr 1:66,214,432...66,481,742
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 increases expression ISO 2,5-hexanedione results in increased expression of MAP3K1 protein CTD PMID:31760062 NCBI chr13:111,882,962...111,954,803
Ensembl chr13:111,882,962...111,945,527
JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO 2,5-hexanedione results in decreased expression of MAPT protein modified form CTD PMID:20554699 NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916
JBrowse link
G Mbp myelin basic protein decreases expression
multiple interactions
ISO 2,5-hexanedione results in decreased expression of MBP protein
Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of MBP protein]
CTD PMID:32522579 PMID:32860822 NCBI chr18:82,492,883...82,603,762
Ensembl chr18:82,493,271...82,603,762
JBrowse link
G Mdh1 malate dehydrogenase 1, NAD (soluble) increases expression ISO 2,5-hexanedione results in increased expression of MDH1 protein CTD PMID:19033394 NCBI chr11:21,506,692...21,521,934
Ensembl chr11:21,506,692...21,522,367
JBrowse link
G Mfap3l microfibrillar-associated protein 3-like increases expression ISO 2,5-hexanedione results in increased expression of MFAP3L mRNA CTD PMID:22952946 NCBI chr 8:61,085,859...61,129,765
Ensembl chr 8:61,085,861...61,129,763
JBrowse link
G Mir10b microRNA 10b increases expression ISO 2,5-hexanedione results in increased expression of MIR10B mRNA CTD PMID:31760062 NCBI chr 2:74,556,414...74,556,481
Ensembl chr 2:74,556,414...74,556,481
JBrowse link
G Mir1224 microRNA 1224 increases expression ISO 2,5-hexanedione results in increased expression of MIR1224 mRNA CTD PMID:31760062 NCBI chr16:20,423,202...20,423,286
Ensembl chr16:20,423,202...20,423,286
JBrowse link
G Mir125a microRNA 125a increases expression
decreases expression
ISO 2,5-hexanedione results in increased expression of MIR125A mRNA
2,5-hexanedione results in decreased expression of MIR125A mRNA
CTD PMID:31760062 NCBI chr17:18,051,074...18,051,141
Ensembl chr17:18,051,074...18,051,141
JBrowse link
G Mir130b microRNA 130b decreases expression ISO 2,5-hexanedione results in decreased expression of MIR130B mRNA CTD PMID:31760062 NCBI chr16:16,941,925...16,942,006
Ensembl chr16:16,941,925...16,942,006
JBrowse link
G Mir134 microRNA 134 decreases expression ISO 2,5-hexanedione results in decreased expression of MIR134 mRNA CTD PMID:31760062 NCBI chr12:109,700,573...109,700,643
Ensembl chr12:109,700,573...109,700,643
JBrowse link
G Mir155 microRNA 155 decreases expression ISO 2,5-hexanedione results in decreased expression of MIR155 mRNA CTD PMID:31760062 NCBI chr16:84,511,028...84,511,092
Ensembl chr16:84,511,028...84,511,092
JBrowse link
G Mir183 microRNA 183 decreases expression ISO 2,5-hexanedione results in decreased expression of MIR183 mRNA CTD PMID:31760062 NCBI chr 6:30,169,667...30,169,736
Ensembl chr 6:30,169,667...30,169,736
JBrowse link
G Mir193a microRNA 193a decreases expression ISO 2,5-hexanedione results in decreased expression of MIR193A mRNA CTD PMID:31760062 NCBI chr11:79,602,795...79,602,860
Ensembl chr11:79,602,795...79,602,860
JBrowse link
G Mir194-2 microRNA 194-2 decreases expression ISO 2,5-hexanedione results in decreased expression of MIR194-2 mRNA CTD PMID:31760062 NCBI chr19:6,314,673...6,314,758
Ensembl chr19:6,314,673...6,314,758
JBrowse link
G Mir196a-1 microRNA 196a-1 increases expression ISO 2,5-hexanedione results in increased expression of MIR196C mRNA CTD PMID:31760062 NCBI chr11:96,155,990...96,156,091
Ensembl chr11:96,155,990...96,156,091
JBrowse link
G Mir196a-2 microRNA 196a-2 increases expression ISO 2,5-hexanedione results in increased expression of MIR196A mRNA CTD PMID:31760062 NCBI chr15:102,881,785...102,881,869
Ensembl chr15:102,881,785...102,881,869
JBrowse link
G Mir199a-2 microRNA 199a-2 decreases expression ISO 2,5-hexanedione results in decreased expression of MIR199A-2 mRNA; 2,5-hexanedione results in decreased expression of MIR199A2 mRNA CTD PMID:31760062 NCBI chr 1:162,045,383...162,045,492
Ensembl chr 1:162,045,383...162,045,492
JBrowse link
G Mir200c microRNA 200c decreases expression ISO 2,5-hexanedione results in decreased expression of MIR200C mRNA CTD PMID:31760062 NCBI chr 6:124,695,285...124,695,353
Ensembl chr 6:124,695,285...124,695,353
JBrowse link
G Mir202 microRNA 202 decreases expression ISO 2,5-hexanedione results in decreased expression of MIR202 mRNA CTD PMID:31760062 NCBI chr 7:139,537,602...139,537,673
Ensembl chr 7:139,537,602...139,537,673
JBrowse link
G Mir206 microRNA 206 decreases expression ISO 2,5-hexanedione results in decreased expression of MIR206 mRNA CTD PMID:31760062 NCBI chr 1:20,749,234...20,749,306
Ensembl chr 1:20,749,234...20,749,306
JBrowse link
G Mir208a microRNA 208a increases expression ISO 2,5-hexanedione results in increased expression of MIR208A mRNA CTD PMID:31760062 NCBI chr14:55,186,517...55,186,599
Ensembl chr14:55,186,517...55,186,599
JBrowse link
G Mir20a microRNA 20a decreases expression ISO 2,5-hexanedione results in decreased expression of MIR20A mRNA CTD PMID:31760062 NCBI chr14:115,281,589...115,281,695
Ensembl chr14:115,281,589...115,281,695
JBrowse link
G Mir212 microRNA 212 increases expression ISO 2,5-hexanedione results in increased expression of MIR212 mRNA CTD PMID:31760062 NCBI chr11:75,064,214...75,064,304
Ensembl chr11:75,064,214...75,064,304
JBrowse link
G Mir214 microRNA 214 increases expression EXP 2,5-hexanedione results in increased expression of MIR214 mRNA CTD PMID:33197454 NCBI chr 1:162,050,937...162,051,046
Ensembl chr 1:162,050,937...162,051,046
JBrowse link
G Mir21a microRNA 21a decreases expression
increases expression
ISO 2,5-hexanedione results in decreased expression of MIR21 mRNA
2,5-hexanedione results in increased expression of MIR21 mRNA
CTD PMID:31760062 NCBI chr11:86,474,893...86,474,984
Ensembl chr11:86,474,893...86,474,984
JBrowse link
G Mir22 microRNA 22 increases expression ISO 2,5-hexanedione results in increased expression of MIR22 mRNA CTD PMID:31760062 NCBI chr11:75,354,542...75,354,636
Ensembl chr11:75,354,542...75,354,636
JBrowse link
G Mir223 microRNA 223 increases expression ISO 2,5-hexanedione results in increased expression of MIR223 mRNA CTD PMID:31760062 NCBI chr  X:95,286,423...95,286,532
Ensembl chr  X:95,286,423...95,286,532
JBrowse link
G Mir224 microRNA 224 increases expression ISO 2,5-hexanedione results in increased expression of MIR224 mRNA CTD PMID:31760062 NCBI chr  X:71,304,637...71,304,718
Ensembl chr  X:71,304,637...71,304,718
JBrowse link
G Mir27a microRNA 27a decreases expression ISO 2,5-hexanedione results in decreased expression of MIR27A mRNA CTD PMID:31760062 NCBI chr 8:84,935,301...84,935,387
Ensembl chr 8:84,935,301...84,935,387
JBrowse link
G Mir27b microRNA 27b increases expression ISO 2,5-hexanedione results in increased expression of MIR27B mRNA CTD PMID:31760062 NCBI chr13:63,448,526...63,448,598
Ensembl chr13:63,448,526...63,448,598
JBrowse link
G Mir30a microRNA 30a increases expression ISO 2,5-hexanedione results in increased expression of MIR30A mRNA CTD PMID:31760062 NCBI chr 1:23,311,350...23,311,420
Ensembl chr 1:23,311,350...23,311,420
JBrowse link
G Mir32 microRNA 32 increases expression ISO 2,5-hexanedione results in increased expression of MIR32 mRNA CTD PMID:31760062 NCBI chr 4:56,895,229...56,895,298
Ensembl chr 4:56,895,229...56,895,298
JBrowse link
G Mir320 microRNA 320 increases expression ISO 2,5-hexanedione results in increased expression of MIR320A mRNA CTD PMID:31760062 NCBI chr14:70,680,950...70,681,031
Ensembl chr14:70,680,950...70,681,031
JBrowse link
G Mir323 microRNA 323 decreases expression ISO 2,5-hexanedione results in decreased expression of MIR323 mRNA CTD PMID:31760062 NCBI chr12:109,678,942...109,679,027
Ensembl chr12:109,678,942...109,679,027
JBrowse link
G Mir326 microRNA 326 increases expression ISO 2,5-hexanedione results in increased expression of MIR326 mRNA CTD PMID:31760062 NCBI chr 7:99,201,476...99,201,570
Ensembl chr 7:99,201,476...99,201,570
JBrowse link
G Mir33 microRNA 33 increases expression ISO 2,5-hexanedione results in increased expression of MIR33 mRNA CTD PMID:31760062 NCBI chr15:82,082,323...82,082,391
Ensembl chr15:82,082,323...82,082,391
JBrowse link
G Mir330 microRNA 330 increases expression ISO 2,5-hexanedione results in increased expression of MIR330 mRNA CTD PMID:31760062 NCBI chr 7:18,915,390...18,915,487
Ensembl chr 7:18,915,390...18,915,487
JBrowse link
G Mir331 microRNA 331 decreases expression ISO 2,5-hexanedione results in decreased expression of MIR331 mRNA CTD PMID:31760062 NCBI chr10:93,799,630...93,799,725
Ensembl chr10:93,799,630...93,799,725
JBrowse link
G Mir339 microRNA 339 increases expression ISO 2,5-hexanedione results in increased expression of MIR339 mRNA CTD PMID:31760062 NCBI chr 5:139,355,405...139,355,500
Ensembl chr 5:139,355,405...139,355,500
JBrowse link
G Mir345 microRNA 345 increases expression ISO 2,5-hexanedione results in increased expression of MIR345 mRNA CTD PMID:31760062 NCBI chr12:108,802,899...108,802,994
Ensembl chr12:108,802,899...108,802,994
JBrowse link
G Mir370 microRNA 370 decreases expression ISO 2,5-hexanedione results in decreased expression of MIR370 mRNA CTD PMID:31760062 NCBI chr12:109,584,692...109,584,770
Ensembl chr12:109,584,692...109,584,770
JBrowse link
G Mir375 microRNA 375 decreases expression ISO 2,5-hexanedione results in decreased expression of MIR375 mRNA CTD PMID:31760062 NCBI chr 1:74,939,817...74,939,880
Ensembl chr 1:74,939,817...74,939,880
JBrowse link
G Mir412 microRNA 412 increases expression ISO 2,5-hexanedione results in increased expression of MIR412 mRNA CTD PMID:31760062 NCBI chr12:109,709,723...109,709,802
Ensembl chr12:109,709,723...109,709,802
JBrowse link
G Mir423 microRNA 423 increases expression ISO 2,5-hexanedione results in increased expression of MIR423 mRNA CTD PMID:31760062 NCBI chr11:76,968,890...76,968,998
Ensembl chr11:76,968,890...76,968,998
JBrowse link
G Mir433 microRNA 433 decreases expression ISO 2,5-hexanedione results in decreased expression of MIR433 mRNA CTD PMID:31760062 NCBI chr12:109,558,149...109,558,272
Ensembl chr12:109,558,149...109,558,272
JBrowse link
G Mir450-1 microRNA 450-1 decreases expression ISO 2,5-hexanedione results in decreased expression of MIR450A1 mRNA CTD PMID:31760062 NCBI chr  X:52,137,031...52,137,121
Ensembl chr  X:52,137,031...52,137,121
JBrowse link
G Mir487b microRNA 487b increases expression ISO 2,5-hexanedione results in increased expression of MIR487B mRNA CTD PMID:31760062 NCBI chr12:109,693,767...109,693,848
Ensembl chr12:109,693,767...109,693,848
JBrowse link
G Mir488 microRNA 488 increases expression ISO 2,5-hexanedione results in increased expression of MIR488 mRNA CTD PMID:31760062 NCBI chr 1:158,333,195...158,333,303
Ensembl chr 1:158,333,195...158,333,303
JBrowse link
G Mir497 microRNA 497 decreases expression ISO 2,5-hexanedione results in decreased expression of MIR497 mRNA CTD PMID:31760062 NCBI chr11:70,125,543...70,125,626
Ensembl chr11:70,125,543...70,125,626
JBrowse link
G Mir503 microRNA 503 decreases expression ISO 2,5-hexanedione results in decreased expression of MIR503 mRNA CTD PMID:31760062 NCBI chr  X:52,142,861...52,142,931
Ensembl chr  X:52,142,861...52,142,931
JBrowse link
G Mir541 microRNA 541 decreases expression ISO 2,5-hexanedione results in decreased expression of MIR541 mRNA CTD PMID:31760062 NCBI chr12:109,708,843...109,708,932
Ensembl chr12:109,708,843...109,708,932
JBrowse link
G Mir542 microRNA 542 increases expression ISO 2,5-hexanedione results in increased expression of MIR542 mRNA CTD PMID:31760062 NCBI chr  X:52,138,280...52,138,364
Ensembl chr  X:52,138,280...52,138,364
JBrowse link
G Mir551b microRNA 551b decreases expression ISO 2,5-hexanedione results in decreased expression of MIR551B mRNA CTD PMID:31760062 NCBI chr 3:29,470,972...29,471,069
Ensembl chr 3:29,470,972...29,471,069
JBrowse link
G Mir582 microRNA 582 increases expression ISO 2,5-hexanedione results in increased expression of MIR582 mRNA CTD PMID:31760062 NCBI chr13:109,461,278...109,461,358
Ensembl chr13:109,461,278...109,461,358
JBrowse link
G Mir652 microRNA 652 decreases expression ISO 2,5-hexanedione results in decreased expression of MIR652 mRNA CTD PMID:31760062 NCBI chr  X:141,521,996...141,522,093
Ensembl chr  X:141,521,996...141,522,093
JBrowse link
G Mir653 microRNA 653 decreases expression ISO 2,5-hexanedione results in decreased expression of MIR653 mRNA CTD PMID:31760062 NCBI chr 6:3,721,301...3,721,385
Ensembl chr 6:3,721,301...3,721,385
JBrowse link
G Mir665 microRNA 665 increases expression ISO 2,5-hexanedione results in increased expression of MIR665 mRNA CTD PMID:31760062 NCBI chr12:109,552,748...109,552,841
Ensembl chr12:109,552,748...109,552,841
JBrowse link
G Mir675 microRNA 675 increases expression ISO 2,5-hexanedione results in increased expression of MIR675 mRNA CTD PMID:31760062 NCBI chr 7:142,130,801...142,130,884
Ensembl chr 7:142,130,801...142,130,884
JBrowse link
G Mir760 microRNA 760 decreases expression ISO 2,5-hexanedione results in decreased expression of MIR760 mRNA CTD PMID:31760062 NCBI chr 3:122,087,234...122,087,352
Ensembl chr 3:122,087,234...122,087,352
JBrowse link
G Mir770 microRNA 770 increases expression ISO 2,5-hexanedione results in increased expression of MIR770 mRNA CTD PMID:31760062 NCBI chr12:109,530,126...109,530,219
Ensembl chr12:109,530,126...109,530,219
JBrowse link
G Mir873a microRNA 873a increases expression ISO 2,5-hexanedione results in increased expression of MIR873 mRNA CTD PMID:31760062 NCBI chr 4:36,668,510...36,668,586
Ensembl chr 4:36,668,510...36,668,586
JBrowse link
G Mir877 microRNA 877 increases expression ISO 2,5-hexanedione results in increased expression of MIR877 mRNA CTD PMID:31760062 NCBI chr17:36,271,622...36,271,706
Ensembl chr17:36,271,622...36,271,706
JBrowse link
G Mirlet7b microRNA let7b increases expression ISO 2,5-hexanedione results in increased expression of MIRLET7B mRNA CTD PMID:31760062 NCBI chr15:85,591,520...85,591,604
Ensembl chr15:85,591,520...85,591,604
JBrowse link
G Mirlet7f-1 microRNA let7f-1 decreases expression ISO 2,5-hexanedione results in decreased expression of MIRLET7F1 mRNA CTD PMID:31760062 NCBI chr13:48,691,305...48,691,393
Ensembl chr13:48,691,305...48,691,393
JBrowse link
G Mirlet7i microRNA let7i increases expression ISO 2,5-hexanedione results in increased expression of MIRLET7I mRNA CTD PMID:31760062 NCBI chr10:122,821,545...122,821,629
Ensembl chr10:122,821,545...122,821,629
JBrowse link
G Mrc1 mannose receptor, C type 1 decreases expression
multiple interactions
ISO 2,5-hexanedione results in decreased expression of MRC1 mRNA
Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of MRC1 mRNA]
CTD PMID:32522579 PMID:32860822 NCBI chr 2:14,234,225...14,336,834
Ensembl chr 2:14,234,203...14,336,868
JBrowse link
G Mtm1 X-linked myotubular myopathy gene 1 increases expression ISO 2,5-hexanedione results in increased expression of MTM1 mRNA CTD PMID:22952946 NCBI chr  X:70,254,373...70,359,019
Ensembl chr  X:70,254,373...70,359,297
JBrowse link
G Napa N-ethylmaleimide sensitive fusion protein attachment protein alpha decreases expression ISO 2,5-hexanedione results in decreased expression of NAPA protein CTD PMID:19033394 NCBI chr 7:15,832,127...15,851,907
Ensembl chr 7:15,832,383...15,851,900
JBrowse link
G Ndufa10 NADH:ubiquinone oxidoreductase subunit A10 increases expression
decreases expression
ISO 2,5-hexanedione results in increased expression of NDUFA10 protein
2,5-hexanedione results in decreased expression of NDUFA10 protein
CTD PMID:19033394 NCBI chr 1:92,367,208...92,401,547
Ensembl chr 1:92,366,732...92,401,582
JBrowse link
G Nefh neurofilament, heavy polypeptide decreases expression ISO 2,5-hexanedione results in decreased expression of NEFH protein CTD PMID:19033394 NCBI chr11:4,888,754...4,898,064
Ensembl chr11:4,888,754...4,898,064
JBrowse link
G Nefl neurofilament, light polypeptide decreases expression
multiple interactions
ISO 2,5-hexanedione results in decreased expression of NEFL protein
Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of NEFL protein]
CTD PMID:19033394 PMID:32522579 PMID:32860822 NCBI chr14:68,321,312...68,326,544
Ensembl chr14:68,321,312...68,326,544
JBrowse link
G Nefm neurofilament, medium polypeptide decreases expression ISO 2,5-hexanedione results in decreased expression of NEFM protein CTD PMID:19033394 NCBI chr14:68,356,994...68,362,453
Ensembl chr14:68,320,039...68,362,295
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression
multiple interactions
ISO 2,5-hexanedione results in increased expression of NLRP3 mRNA; 2,5-hexanedione results in increased expression of NLRP3 protein
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of NLRP3 protein]
CTD PMID:32522579 PMID:32860822 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782
JBrowse link
G Nos2 nitric oxide synthase 2, inducible increases expression
multiple interactions
ISO 2,5-hexanedione results in increased expression of NOS2 mRNA
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of NOS2 mRNA]
CTD PMID:32522579 PMID:32860822 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Nsf N-ethylmaleimide sensitive fusion protein decreases expression ISO 2,5-hexanedione results in decreased expression of NSF protein CTD PMID:19033394 NCBI chr11:103,712,608...103,844,882
Ensembl chr11:103,712,608...103,844,882
JBrowse link
G Nupr2 nuclear protein transcriptional regulator 2 increases expression ISO 2,5-hexanedione results in increased expression of NUPR2 mRNA CTD PMID:22952946 NCBI chr 5:129,937,381...129,942,629
Ensembl chr 5:129,937,381...129,942,630
JBrowse link
G Pdia3 protein disulfide isomerase associated 3 decreases expression ISO 2,5-hexanedione results in decreased expression of PDIA3 protein CTD PMID:19033394 NCBI chr 2:121,244,383...121,269,168
Ensembl chr 2:121,244,256...121,269,168
JBrowse link
G Pdlim3 PDZ and LIM domain 3 decreases expression ISO 2,5-hexanedione results in decreased expression of PDLIM3 protein CTD PMID:19033394 NCBI chr 8:46,338,524...46,372,672
Ensembl chr 8:46,338,498...46,372,585
JBrowse link
G Pgam1 phosphoglycerate mutase 1 increases expression ISO 2,5-hexanedione results in increased expression of PGAM1 protein CTD PMID:19033394 NCBI chr19:41,900,310...41,907,104
Ensembl chr19:41,900,362...41,907,099
JBrowse link
G Phospho1 phosphatase, orphan 1 increases expression ISO 2,5-hexanedione results in increased expression of PHOSPHO1 mRNA CTD PMID:22952946 NCBI chr11:95,715,326...95,722,966
Ensembl chr11:95,715,325...95,722,966
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha decreases expression EXP 2,5-hexanedione results in decreased expression of PIK3CA mRNA CTD PMID:33197454 NCBI chr 3:32,451,203...32,520,256
Ensembl chr 3:32,451,820...32,522,635
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 decreases expression EXP 2,5-hexanedione results in decreased expression of PIK3R1 protein CTD PMID:33197454 NCBI chr13:101,817,269...101,904,725
Ensembl chr13:101,817,071...101,904,725
JBrowse link
G Pim1 proviral integration site 1 increases expression ISO 2,5-hexanedione results in increased expression of PIM1 mRNA CTD PMID:22952946 NCBI chr17:29,709,759...29,715,085
Ensembl chr17:29,709,727...29,715,086
JBrowse link
G Pkm pyruvate kinase, muscle increases expression ISO 2,5-hexanedione results in increased expression of PKM protein CTD PMID:19033394 NCBI chr 9:59,563,859...59,586,655
Ensembl chr 9:59,563,651...59,586,658
JBrowse link
G Pou2f1 POU domain, class 2, transcription factor 1 increases expression ISO 2,5-hexanedione results in increased expression of POU2F1 mRNA CTD PMID:22952946 NCBI chr 1:165,692,719...165,830,318
Ensembl chr 1:165,692,723...165,830,247
JBrowse link
G Prkcsh protein kinase C substrate 80K-H decreases expression ISO 2,5-hexanedione results in decreased expression of PRKCSH protein CTD PMID:19033394 NCBI chr 9:21,914,314...21,925,521
Ensembl chr 9:21,914,102...21,925,518
JBrowse link
G Ptgds prostaglandin D2 synthase (brain) increases expression ISO 2,5-hexanedione results in increased expression of PTGDS mRNA CTD PMID:22952946 PMID:27466211 NCBI chr 2:25,356,723...25,360,080
Ensembl chr 2:25,356,721...25,360,058
JBrowse link
G Pycard PYD and CARD domain containing increases expression ISO 2,5-hexanedione results in increased expression of PYCARD mRNA; 2,5-hexanedione results in increased expression of PYCARD protein CTD PMID:32860822 NCBI chr 7:127,590,545...127,593,039
Ensembl chr 7:127,588,880...127,593,039
JBrowse link
G Pygb brain glycogen phosphorylase decreases expression ISO 2,5-hexanedione results in decreased expression of PYGB protein CTD PMID:19033394 NCBI chr 2:150,628,716...150,673,668
Ensembl chr 2:150,628,655...150,673,678
JBrowse link
G Pygm muscle glycogen phosphorylase decreases expression ISO 2,5-hexanedione results in decreased expression of PYGM protein CTD PMID:19033394 NCBI chr19:6,434,438...6,448,494
Ensembl chr19:6,434,429...6,448,489
JBrowse link
G Ralgapa2 Ral GTPase activating protein, alpha subunit 2 (catalytic) increases expression ISO 2,5-hexanedione results in increased expression of RALGAPA2 mRNA CTD PMID:22952946 NCBI chr 2:146,079,326...146,354,174
Ensembl chr 2:146,081,799...146,354,264
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO 2,5-hexanedione results in decreased expression of and affects the localization of RELA protein CTD PMID:22337490 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Rtkn2 rhotekin 2 increases expression ISO 2,5-hexanedione results in increased expression of RTKN2 mRNA CTD PMID:22952946 NCBI chr10:67,815,371...67,894,259
Ensembl chr10:67,815,400...67,895,570
JBrowse link
G S100z S100 calcium binding protein, zeta increases expression ISO 2,5-hexanedione results in increased expression of S100Z mRNA CTD PMID:22952946 NCBI chr13:95,613,809...95,615,163
Ensembl chr13:95,613,776...95,615,229
JBrowse link
G Sclt1 sodium channel and clathrin linker 1 increases expression ISO 2,5-hexanedione results in increased expression of SCLT1 mRNA CTD PMID:22952946 NCBI chr 3:41,581,140...41,696,968
Ensembl chr 3:41,581,155...41,696,949
JBrowse link
G Septin8 septin 8 decreases expression ISO 2,5-hexanedione results in decreased expression of SEPTIN8 protein CTD PMID:19033394 NCBI chr11:53,410,224...53,440,432
Ensembl chr11:53,410,084...53,440,392
JBrowse link
G Sh2d4a SH2 domain containing 4A decreases expression ISO 2,5-hexanedione results in decreased expression of SH2D4A mRNA CTD PMID:22952946 NCBI chr 8:68,729,180...68,800,356
Ensembl chr 8:68,729,219...68,800,351
JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 multiple interactions ISO [carbendazim co-treated with 2,5-hexanedione] affects the expression of SHANK3 mRNA CTD PMID:22382377 NCBI chr15:89,376,929...89,444,464
Ensembl chr15:89,383,826...89,444,464
JBrowse link
G Sil1 SIL1 nucleotide exchange factor increases expression ISO 2,5-hexanedione results in increased expression of SIL1 mRNA CTD PMID:22952946 NCBI chr18:35,399,449...35,632,443
Ensembl chr18:35,399,449...35,632,833
JBrowse link
G Slc10a7 solute carrier family 10 (sodium/bile acid cotransporter family), member 7 increases expression ISO 2,5-hexanedione results in increased expression of SLC10A7 mRNA CTD PMID:22952946 NCBI chr 8:79,235,957...79,460,641
Ensembl chr 8:79,235,975...79,460,632
JBrowse link
G Sltm SAFB-like, transcription modulator increases expression ISO 2,5-hexanedione results in increased expression of SLTM mRNA CTD PMID:22952946 NCBI chr 9:70,449,717...70,499,519
Ensembl chr 9:70,450,036...70,499,516
JBrowse link
G Sod3 superoxide dismutase 3, extracellular increases expression ISO 2,5-hexanedione results in increased expression of SOD3 mRNA CTD PMID:22952946 PMID:27466211 NCBI chr 5:52,521,146...52,527,080
Ensembl chr 5:52,521,133...52,528,760
JBrowse link
G Sppl3 signal peptide peptidase 3 increases expression ISO 2,5-hexanedione results in increased expression of SPPL3 mRNA CTD PMID:22952946 NCBI chr 5:115,149,204...115,236,849
Ensembl chr 5:115,149,196...115,236,849
JBrowse link
G Sptan1 spectrin alpha, non-erythrocytic 1 decreases expression ISO 2,5-hexanedione results in decreased expression of SPTAN1 protein CTD PMID:19033394 NCBI chr 2:29,855,572...29,921,463
Ensembl chr 2:29,855,572...29,921,463
JBrowse link
G Stmn1 stathmin 1 decreases expression ISO 2,5-hexanedione results in decreased expression of STMN1 mRNA CTD PMID:22952946 NCBI chr 4:134,195,631...134,201,154
Ensembl chr 4:134,195,631...134,201,154
JBrowse link
G Strbp spermatid perinuclear RNA binding protein increases expression ISO 2,5-hexanedione results in increased expression of STRBP mRNA CTD PMID:22952946 NCBI chr 2:37,459,880...37,593,890
Ensembl chr 2:37,373,240...37,593,871
JBrowse link
G Styxl1 serine/threonine/tyrosine interacting-like 1 increases expression ISO 2,5-hexanedione results in increased expression of STYXL1 mRNA CTD PMID:22952946 NCBI chr 5:135,776,074...135,807,277
Ensembl chr 5:135,776,074...135,807,239
JBrowse link
G Tax1bp1 Tax1 (human T cell leukemia virus type I) binding protein 1 increases expression ISO 2,5-hexanedione results in increased expression of TAX1BP1 mRNA CTD PMID:22952946 NCBI chr 6:52,690,677...52,743,765
Ensembl chr 6:52,690,714...52,743,765
JBrowse link
G Tbc1d5 TBC1 domain family, member 5 increases expression ISO 2,5-hexanedione results in increased expression of TBC1D5 mRNA CTD PMID:22952946 NCBI chr17:51,040,155...51,488,228
Ensembl chr17:51,040,152...51,486,380
JBrowse link
G Tmem192 transmembrane protein 192 increases expression ISO 2,5-hexanedione results in increased expression of TMEM192 mRNA CTD PMID:22952946 NCBI chr 8:65,399,801...65,421,688
Ensembl chr 8:65,399,837...65,421,685
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of TNF mRNA] CTD PMID:32522579 PMID:32860822 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tpi1 triosephosphate isomerase 1 increases expression ISO 2,5-hexanedione results in increased expression of TPI1 mRNA; 2,5-hexanedione results in increased expression of TPI1 protein CTD PMID:19033394 PMID:22952946 NCBI chr 6:124,787,549...124,791,121
Ensembl chr 6:124,787,549...124,791,259
JBrowse link
G Uba1 ubiquitin-like modifier activating enzyme 1 increases expression ISO 2,5-hexanedione results in increased expression of UBA1 protein CTD PMID:19033394 NCBI chr  X:20,524,660...20,549,420
Ensembl chr  X:20,524,565...20,549,418
JBrowse link
G Ubn2 ubinuclein 2 increases expression ISO 2,5-hexanedione results in increased expression of UBN2 mRNA CTD PMID:22952946 NCBI chr 6:38,410,860...38,489,698
Ensembl chr 6:38,410,885...38,501,760
JBrowse link
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 decreases expression ISO 2,5-hexanedione results in decreased expression of UQCRC2 mRNA CTD PMID:22952946 NCBI chr 7:120,234,412...120,258,746
Ensembl chr 7:120,234,399...120,258,747
JBrowse link
G Vim vimentin multiple interactions ISO 2,5-hexanedione promotes the reaction [VIM protein binds to VIM protein] CTD PMID:6361548 NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO 2,5-hexanedione results in decreased expression of XIAP mRNA CTD PMID:22337490 NCBI chr  X:41,148,483...41,198,541
Ensembl chr  X:41,148,556...41,198,533
JBrowse link
G Zfp169 zinc finger protein 169 decreases expression ISO 2,5-hexanedione results in decreased expression of ZFP169 protein CTD PMID:19033394 NCBI chr13:48,634,239...48,666,969
Ensembl chr13:48,641,123...48,666,927
JBrowse link
G Zfp407 zinc finger protein 407 increases expression ISO 2,5-hexanedione results in increased expression of ZFP407 mRNA CTD PMID:22952946 NCBI chr18:84,225,826...84,612,815
Ensembl chr18:84,146,152...84,607,850
JBrowse link
3',4'-dihydroxyacetophenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase increases methylation ISO COMT protein results in increased methylation of 3,4-dihydroxyacetophenone CTD PMID:11160877 NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602
JBrowse link
3,4-dihydroxyacetophenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase increases methylation ISO COMT protein results in increased methylation of 3,4-dihydroxyacetophenone CTD PMID:11160877 NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602
JBrowse link
4'-hydroxyacetophenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh1 alcohol dehydrogenase 1 (class I) affects binding ISO p-hydroxyacetophenone binds to Adh1 protein RGD PMID:16385241 RGD:1642947 NCBI chr 3:137,983,346...137,996,459
Ensembl chr 3:137,966,752...137,996,459
JBrowse link
G Adk adenosine kinase affects binding ISO 4-hydroxyacetophenone binds to ADK protein CTD PMID:15236443 NCBI chr14:21,102,622...21,498,637
Ensembl chr14:21,102,642...21,498,637
JBrowse link
G Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 affects binding ISO 4-hydroxyacetophenone binds to ALDH1A1 protein CTD PMID:15236443 NCBI chr19:20,469,947...20,620,827
Ensembl chr19:20,470,079...20,620,829
JBrowse link
G Gsta2 glutathione S-transferase, alpha 2 (Yc2) affects binding ISO 4-hydroxyacetophenone binds to GSTA2 protein CTD PMID:15236443 NCBI chr 9:78,238,300...78,254,474
Ensembl chr 9:78,238,300...78,263,070
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases activity
increases expression
ISO 4-hydroxyacetophenone results in increased activity of NR1H4 protein
4-hydroxyacetophenone results in increased expression of NR1H4 mRNA
CTD PMID:36542898 NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447
JBrowse link
G Pygl liver glycogen phosphorylase affects binding ISO 4-hydroxyacetophenone binds to PYGL protein CTD PMID:15236443 NCBI chr12:70,237,589...70,274,457
Ensembl chr12:70,237,585...70,278,262
JBrowse link
4-methoxyacetophenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl15 C-X-C motif chemokine ligand 15 increases expression ISO 4-acetylanisole results in increased expression of CXCL8 mRNA CTD PMID:21920952 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO 4-acetylanisole results in increased expression of HMOX1 mRNA CTD PMID:26244607 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
4-nitroacetophenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhrs3 dehydrogenase/reductase 3 increases metabolic processing ISO DHRS3 protein results in increased metabolism of 4-nitroacetophenone CTD PMID:25451588 NCBI chr 4:144,618,712...144,654,214
Ensembl chr 4:144,619,397...144,654,779
JBrowse link
acenocoumarol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A affects response to substance ISO ABCB1 gene polymorphism affects the susceptibility to Acenocoumarol CTD PMID:18021343 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
JBrowse link
G Apoe apolipoprotein E affects response to substance ISO APOE gene polymorphism affects the susceptibility to Acenocoumarol CTD PMID:15861030 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 affects metabolic processing ISO CYP1A1 protein affects the metabolism of Acenocoumarol CTD PMID:11918509 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing ISO CYP1A2 protein affects the metabolism of Acenocoumarol CTD PMID:11918509 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 affects metabolic processing ISO CYP2C19 protein affects the metabolism of Acenocoumarol CTD PMID:11918509 NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519
JBrowse link
G Cyp2c52-ps cytochrome P450, family 2, subfamily c, polypeptide 52, pseudogene affects response to substance ISO CYP2C18 gene polymorphism affects the susceptibility to Acenocoumarol CTD PMID:19578179 NCBI chr19:38,965,106...38,992,071
Ensembl chr19:38,965,091...38,991,733
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 increases metabolic processing
increases response to substance
affects response to substance
affects metabolic processing
ISO CYP2C9 protein results in increased metabolism of Acenocoumarol
CYP2C9 protein results in increased susceptibility to Acenocoumarol
CYP2C9 gene polymorphism affects the susceptibility to Acenocoumarol; CYP2C9 gene SNP affects the susceptibility to Acenocoumarol
CYP2C9 protein affects the metabolism of Acenocoumarol
CTD PMID:11918509 PMID:15213846 PMID:16869821 PMID:16878445 PMID:18021343 More... NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388
JBrowse link
G F10 coagulation factor X decreases activity ISO Acenocoumarol results in decreased activity of F10 protein CTD PMID:3490277 NCBI chr 8:13,087,308...13,106,676
Ensembl chr 8:13,087,308...13,106,676
JBrowse link
G F2 coagulation factor II decreases activity ISO Acenocoumarol results in decreased activity of F2 protein CTD PMID:3490277 NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759
JBrowse link
G F5 coagulation factor V decreases activity ISO Acenocoumarol results in decreased activity of F5 protein CTD PMID:3490277 NCBI chr 1:163,979,396...164,048,539
Ensembl chr 1:163,979,407...164,047,846
JBrowse link
G F7 coagulation factor VII decreases activity ISO Acenocoumarol results in decreased activity of F7 protein CTD PMID:3490277 NCBI chr 8:13,075,499...13,085,809
Ensembl chr 8:13,076,034...13,085,809
JBrowse link
G F9 coagulation factor IX decreases activity ISO Acenocoumarol results in decreased activity of F9 protein CTD PMID:3490277 NCBI chr  X:59,044,675...59,076,120
Ensembl chr  X:59,044,824...59,076,119
JBrowse link
G Ggcx gamma-glutamyl carboxylase increases activity ISO Acenocoumarol results in increased activity of GGCX protein CTD PMID:3490277 NCBI chr 6:72,391,262...72,407,696
Ensembl chr 6:72,391,291...72,407,695
JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 decreases response to substance
decreases activity
multiple interactions
affects response to substance
increases response to substance
ISO VKORC1 promoter polymorphism results in decreased susceptibility to Acenocoumarol; VKORC1 protein polymorphism results in decreased susceptibility to Acenocoumarol
Acenocoumarol results in decreased activity of VKORC1 protein
Acenocoumarol inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]
VKORC1 gene polymorphism affects the susceptibility to Acenocoumarol; VKORC1 gene SNP affects the susceptibility to Acenocoumarol; VKORC1 intron SNP affects the susceptibility to Acenocoumarol; VKORC1 polymorphism affects the susceptibility to Acenocoumarol; VKORC1 protein polymorphism affects the susceptibility to Acenocoumarol
VKORC1 protein results in increased susceptibility to Acenocoumarol
CTD PMID:16201835 PMID:16611310 PMID:16869821 PMID:17036862 PMID:18698879 More... NCBI chr 7:127,492,235...127,494,833
Ensembl chr 7:127,485,399...127,494,626
Ensembl chr 7:127,485,399...127,494,626
JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 multiple interactions
decreases activity
ISO Acenocoumarol inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]
Acenocoumarol results in decreased activity of VKORC1L1 protein
CTD PMID:29581108 NCBI chr 5:129,970,950...130,015,533
Ensembl chr 5:129,970,811...130,015,533
JBrowse link
acepromazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase increases activity EXP Acepromazine results in increased activity of ACHE protein CTD PMID:29614332 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
JBrowse link
acetohexamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO Acetohexamide binds to ALB protein; Acetohexamide binds to ALB protein modified form CTD PMID:20435530 PMID:20829128 PMID:20956006 PMID:20974553 PMID:21612784 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
JBrowse link
G Dhrs3 dehydrogenase/reductase 3 increases metabolic processing ISO DHRS3 protein results in increased metabolism of Acetohexamide CTD PMID:25451588 NCBI chr 4:144,618,712...144,654,214
Ensembl chr 4:144,619,397...144,654,779
JBrowse link
acetoin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B increases reduction
multiple interactions
ISO AKR1B1 protein results in increased reduction of Acetoin
[AKR1B1 protein results in increased reduction of Acetoin] which results in increased chemical synthesis of 2,3-butylene glycol; [AKR1B1 protein results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin
CTD PMID:23295224 NCBI chr 6:34,280,865...34,294,424
Ensembl chr 6:34,279,369...34,294,413
JBrowse link
G Akr1b10 aldo-keto reductase family 1, member B10 increases reduction
multiple interactions
ISO AKR1B10 protein results in increased reduction of Acetoin
[AKR1B10 protein results in increased reduction of Acetoin] which results in increased chemical synthesis of 2,3-butylene glycol; [AKR1B10 protein results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin
CTD PMID:23295224 NCBI chr 6:34,361,182...34,373,884
Ensembl chr 6:34,361,153...34,373,885
JBrowse link
G Dcxr dicarbonyl L-xylulose reductase multiple interactions ISO 1,2-naphthoquinone inhibits the reaction [[[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin]; 1,4-naphthoquinone inhibits the reaction [[[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin]; 9,10-phenanthrenequinone inhibits the reaction [[[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin]; [[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin; [DCXR protein co-treated with NAD] results in increased chemical synthesis of Acetoin; Vitamin K 3 inhibits the reaction [[[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin] CTD PMID:28595002 NCBI chr11:120,615,372...120,618,110
Ensembl chr11:120,616,225...120,618,107
JBrowse link
acetone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh1 alcohol dehydrogenase 1 (class I) multiple interactions EXP [ADH1 protein results in increased oxidation of allyl alcohol] which results in increased abundance of Acetone CTD PMID:11981770 NCBI chr 3:137,983,346...137,996,459
Ensembl chr 3:137,966,752...137,996,459
JBrowse link
G Cat catalase decreases activity ISO Acetone results in decreased activity of CAT protein CTD PMID:16169704 PMID:20127315 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO Acetone results in increased expression of CCND1 mRNA CTD PMID:12720008 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Acetone promotes the reaction [Toluene results in increased expression of CYP1A1 protein] CTD PMID:8996725 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression
ISO Acetone promotes the reaction [Toluene results in increased expression of CYP1A2 protein]
acetone increased expression of Cyp1a2 protein in thoracic aorta of rats
CTD
RGD
PMID:8996725 PMID:12688525 RGD:401900656 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 multiple interactions ISO Acetone promotes the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide] CTD PMID:10611138 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression
increases activity
increases metabolic processing
EXP
ISO
[Acetone results in increased activity of CYP2E1 protein] which results in increased oxidation of Benzene; [Acetone results in increased expression of CYP2E1 protein] which results in increased susceptibility to allyl cyanide; Acetone results in increased expression of and results in increased activity of CYP2E1 protein
Acetone results in increased expression of CYP2E1 mRNA; Acetone results in increased expression of CYP2E1 protein
1,2-dichloroethylene inhibits the reaction [Acetone results in increased activity of CYP2E1 protein]; [Acetone co-treated with ciprofibrate] results in increased expression of CYP2E1 protein; [Acetone co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 mRNA; [Acetone co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 protein; [Acetone co-treated with Methylcholanthrene] results in increased activity of CYP2E1 protein; [Acetone co-treated with Methylcholanthrene] results in increased expression of CYP2E1 protein; Acetone promotes the reaction [2-xylene results in increased expression of CYP2E1 protein]; Acetone promotes the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol]; Acetone promotes the reaction [Toluene results in increased expression of CYP2E1 protein]; Trichloroethylene inhibits the reaction [Acetone results in increased activity of CYP2E1 protein]
CYP2E1 protein results in increased metabolism of Acetone
CTD PMID:1968335 PMID:2241968 PMID:3416296 PMID:3782137 PMID:7587954 More... NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 increases expression ISO Acetone results in increased expression of FGFR2 mRNA CTD PMID:12720008 NCBI chr 7:129,764,181...129,868,538
Ensembl chr 7:129,764,181...132,725,079
JBrowse link
G Fn1 fibronectin 1 increases expression ISO Acetone results in increased expression of FN1 mRNA CTD PMID:33064461 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359
JBrowse link
G Il13 interleukin 13 multiple interactions ISO [Acetone co-treated with Olive Oil] results in increased expression of IL13 mRNA CTD PMID:21252390 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529
JBrowse link
G Il4 interleukin 4 multiple interactions ISO [Acetone co-treated with Olive Oil] results in increased expression of IL4 mRNA CTD PMID:21252390 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
JBrowse link
G Il5 interleukin 5 multiple interactions ISO [Acetone co-treated with Olive Oil] results in increased expression of IL5 mRNA CTD PMID:21252390 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933
JBrowse link
G Itga5 integrin alpha 5 (fibronectin receptor alpha) increases expression ISO Acetone results in increased expression of ITGA5 mRNA CTD PMID:12720008 NCBI chr15:103,252,713...103,275,218
Ensembl chr15:103,252,713...103,275,190
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression EXP Acetone results in increased expression of NQO1 mRNA CTD PMID:9496914 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Acetone co-treated with Olive Oil] results in increased expression of TNF mRNA CTD PMID:21252390 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Trpm8 transient receptor potential cation channel, subfamily M, member 8 increases response to substance EXP TRPM8 protein results in increased susceptibility to Acetone CTD PMID:17481392 NCBI chr 1:88,234,457...88,318,909
Ensembl chr 1:88,205,383...88,317,015
JBrowse link
acetophenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2, mitochondrial multiple interactions ISO acetophenone inhibits the reaction [4-dimethylaminocinnamaldehyde binds to ALDH2 protein] CTD PMID:10609638 NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887
JBrowse link
G Esr2 estrogen receptor 2 (beta) multiple interactions ISO acetophenone binds to and results in decreased activity of ESR2 protein CTD PMID:27633901 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033
JBrowse link
G Or8a1b olfactory receptor family 8 subfamily A member 1B multiple interactions
increases activity
EXP acetophenone binds to and results in increased activity of OR8A1 protein
acetophenone results in increased activity of OR8A1 protein
CTD PMID:11943806 PMID:19052201 NCBI chr 9:37,622,644...37,623,576
Ensembl chr 9:37,620,260...37,627,546
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions ISO acetophenone binds to and results in decreased activity of PPARG protein CTD PMID:27633901 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity ISO acetophenone results in increased activity of TRPA1 protein CTD PMID:27545873 NCBI chr 1:14,942,868...14,989,086
Ensembl chr 1:14,942,872...14,989,086
JBrowse link
alpha-ionone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gna15 guanine nucleotide binding protein, alpha 15 multiple interactions
increases response to substance
ISO [GNA15 protein results in increased susceptibility to alpha-ionone] which results in increased activity of OR1A1B protein CTD PMID:15598656 NCBI chr10:81,338,147...81,360,283
Ensembl chr10:81,338,140...81,360,059
JBrowse link
G Or1a1b olfactory receptor family 1 subfamily A member 1B multiple interactions ISO [GNA15 protein results in increased susceptibility to alpha-ionone] which results in increased activity of OR1A1B protein CTD PMID:15598656 NCBI chr11:74,097,024...74,098,115
Ensembl chr11:74,096,490...74,102,205
JBrowse link
G Or51e2 olfactory receptor family 51 subfamily E member 2 decreases activity ISO alpha-ionone results in decreased activity of OR51E2 protein CTD PMID:27226631 NCBI chr 7:102,389,928...102,408,678
Ensembl chr 7:102,387,718...102,408,678
JBrowse link
aminoacetone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions ISO CAT protein results in decreased susceptibility to [aminoacetone co-treated with Copper] CTD PMID:18729331 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Gsr glutathione reductase multiple interactions ISO [aminoacetone co-treated with Copper] results in increased expression of GSR mRNA CTD PMID:18729331 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions ISO [aminoacetone co-treated with Copper] results in increased expression of SOD1 mRNA CTD PMID:18729331 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions ISO [aminoacetone co-treated with Copper] results in increased expression of SOD2 mRNA CTD PMID:18729331 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
apocynin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A multiple interactions ISO acetovanillone inhibits the reaction [Particulate Matter results in increased expression of and results in increased activity of ABCB1 protein]; acetovanillone inhibits the reaction [Vehicle Emissions results in increased expression of and results in increased activity of ABCB1 protein] CTD PMID:18474546 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions ISO acetovanillone inhibits the reaction [Mitogens results in increased expression of ACTA2 protein] CTD PMID:29760339 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990
JBrowse link
G Agt angiotensinogen multiple interactions
decreases activity
ISO
EXP
[acetovanillone co-treated with AGT protein] results in increased expression of and affects the localization of NFE2L2 protein; acetovanillone inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]]
acetovanillone results in decreased activity of AGT protein
acetovanillone inhibits the reaction [AGT protein results in decreased export of Sodium]; acetovanillone inhibits the reaction [AGT protein results in increased abundance of Oxygen]; acetovanillone inhibits the reaction [AGT protein results in increased abundance of Reactive Oxygen Species]; acetovanillone inhibits the reaction [AGT protein results in increased abundance of Superoxides]; acetovanillone inhibits the reaction [AGT protein results in increased expression of COL1A2 mRNA]; acetovanillone inhibits the reaction [AGT protein results in increased expression of COL1A2 protein]; acetovanillone inhibits the reaction [AGT protein results in increased expression of COL3A1 mRNA]; acetovanillone inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; acetovanillone inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]
acetovanillone inhibits the reaction [AGT protein results in increased abundance of Superoxides]; acetovanillone inhibits the reaction [AGT protein results in increased activity of PARP1 protein]; acetovanillone inhibits the reaction [AGT protein results in increased expression of EDN1 mRNA]
CTD PMID:14597645 PMID:15502880 PMID:15677497 PMID:16531806 PMID:17224469 More... NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445
JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions EXP acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of AIF1 protein]; acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of AIF1 protein] CTD PMID:28202386 PMID:30366073 NCBI chr17:35,389,967...35,394,977
Ensembl chr17:35,389,967...35,395,044
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B multiple interactions ISO acetovanillone inhibits the reaction [Uric Acid results in increased expression of AKR1B1 mRNA] CTD PMID:30651350 NCBI chr 6:34,280,865...34,294,424
Ensembl chr 6:34,279,369...34,294,413
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO acetovanillone inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein] CTD PMID:26514923 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Alb albumin multiple interactions ISO acetovanillone inhibits the reaction [Mitogens results in decreased expression of ALB protein] CTD PMID:29760339 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
JBrowse link
G Alpl alkaline phosphatase, liver/bone/kidney multiple interactions ISO acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of ALPL mRNA] CTD PMID:24080574 NCBI chr 4:137,469,042...137,523,695
Ensembl chr 4:137,469,044...137,523,695
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO acetovanillone inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of ATF2 protein] CTD PMID:22288910 NCBI chr 2:73,646,853...73,723,094
Ensembl chr 2:73,646,853...73,722,983
JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO
EXP
acetovanillone analog inhibits the reaction [Chlorpyrifos results in increased expression of BAX protein]; acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of BAX protein]
acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of BAX protein]
CTD PMID:22431579 PMID:29859868 PMID:30366073 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO
EXP
acetovanillone analog inhibits the reaction [Chlorpyrifos results in decreased expression of BCL2 protein]; acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of BCL2 protein]
acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in decreased expression of BCL2 protein]
CTD PMID:22431579 PMID:29859868 PMID:30366073 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions EXP acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in decreased expression of BCL2L1 protein] CTD PMID:30366073 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648
JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions ISO acetovanillone analog inhibits the reaction [Chlorpyrifos results in increased expression of BECN1 protein] CTD PMID:29859868 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112
JBrowse link
G Bglap bone gamma carboxyglutamate protein multiple interactions ISO acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of BGLAP mRNA] CTD PMID:24080574 NCBI chr 3:88,290,802...88,291,773
Ensembl chr 3:88,290,808...88,291,771
JBrowse link
G Casp1 caspase 1 multiple interactions ISO acetovanillone inhibits the reaction [Ethanol results in increased expression of CASP1 protein modified form]; acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased secretion of CASP1 protein modified form] CTD PMID:26079697 PMID:26901245 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
acetovanillone analog inhibits the reaction [Chlorpyrifos results in increased cleavage of CASP3 protein]; acetovanillone inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; acetovanillone inhibits the reaction [Ethanol results in increased cleavage of and results in increased activity of CASP3 protein]; acetovanillone inhibits the reaction [Ethanol results in increased expression of CASP3 protein]
acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased cleavage of CASP3 protein]; acetovanillone inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]
[tempol co-treated with UCF 101 co-treated with acetovanillone] inhibits the reaction [S-Nitrosoglutathione results in increased activity of CASP3 protein]; acetovanillone inhibits the reaction [perfluorooctane sulfonic acid results in increased cleavage of CASP3 mRNA]
CTD PMID:20153346 PMID:22147442 PMID:22497828 PMID:24291008 PMID:26522475 More... NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Cat catalase multiple interactions ISO [acetovanillone co-treated with CAT protein] inhibits the reaction [Cyclosporine results in increased expression of NOX4 mRNA]; [acetovanillone results in increased susceptibility to Thioctic Acid] inhibits the reaction [Mitogens results in decreased activity of CAT protein]; acetovanillone inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; acetovanillone inhibits the reaction [Formaldehyde results in increased expression of CAT mRNA]; acetovanillone inhibits the reaction [Mitogens results in decreased activity of CAT protein]; acetovanillone inhibits the reaction [Pyrogallol results in increased activity of CAT protein]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in decreased activity of CAT protein]] CTD PMID:21983654 PMID:24291008 PMID:29760339 PMID:32298299 PMID:35944648 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA] CTD PMID:22414048 NCBI chr11:81,948,658...81,953,781
Ensembl chr11:81,948,649...81,953,781
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO acetovanillone inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; acetovanillone inhibits the reaction [Homocysteine results in increased expression of CCL2 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL2 protein] CTD PMID:16845898 PMID:19158351 PMID:22414048 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO
EXP
acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL5 protein]
acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]
CTD PMID:10495789 PMID:22414048 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL7 mRNA] CTD PMID:22414048 NCBI chr11:81,936,538...81,938,351
Ensembl chr11:81,936,538...81,938,351
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO acetovanillone inhibits the reaction [[Oxygen deficiency results in increased abundance of Reactive Oxygen Species] which results in increased expression of CD36 mRNA] CTD PMID:19640849 NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799
JBrowse link
G Cdh3 cadherin 3 multiple interactions EXP acetovanillone inhibits the reaction [Homocysteine results in decreased expression of CDH3 protein] CTD PMID:21647593 NCBI chr 8:107,237,484...107,283,543
Ensembl chr 8:107,237,523...107,283,929
JBrowse link
G Col1a2 collagen, type I, alpha 2 multiple interactions ISO acetovanillone inhibits the reaction [AGT protein results in increased expression of COL1A2 mRNA]; acetovanillone inhibits the reaction [AGT protein results in increased expression of COL1A2 protein] CTD PMID:16531806 NCBI chr 6:4,505,618...4,541,543
Ensembl chr 6:4,504,814...4,541,544
JBrowse link
G Col3a1 collagen, type III, alpha 1 multiple interactions ISO acetovanillone inhibits the reaction [AGT protein results in increased expression of COL3A1 mRNA]; acetovanillone inhibits the reaction [AGT protein results in increased expression of COL3A1 protein] CTD PMID:16531806 NCBI chr 1:45,350,698...45,388,866
Ensembl chr 1:45,350,698...45,388,866
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP acetovanillone inhibits the reaction [Antimycin A results in decreased phosphorylation of CREB1 protein] CTD PMID:21538410 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707
JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in increased expression of CSF2 mRNA] CTD PMID:22414048 NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493
JBrowse link
G Ctf1 cardiotrophin 1 multiple interactions EXP acetovanillone inhibits the reaction [cobaltous chloride results in increased expression of CTF1 protein]; acetovanillone inhibits the reaction [Vitamin K 3 results in increased expression of CTF1 protein] CTD PMID:16507596 NCBI chr 7:127,311,872...127,317,360
Ensembl chr 7:127,311,908...127,317,364
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL1 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL1 protein] CTD PMID:22414048 NCBI chr 5:91,039,104...91,040,980
Ensembl chr 5:91,039,100...91,040,974
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL10 mRNA]; acetovanillone inhibits the reaction [vanadium pentoxide results in increased expression of CXCL10 mRNA] CTD PMID:18322232 PMID:22414048 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748
JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions ISO acetovanillone inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL8 protein] CTD PMID:20920494 PMID:22414048 PMID:27393034 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL1 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL1 protein] CTD PMID:22414048 NCBI chr 5:90,933,960...90,935,952
Ensembl chr 5:90,933,962...90,937,459
JBrowse link
G Cyba cytochrome b-245, alpha polypeptide multiple interactions ISO
EXP
acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBA mRNA]; acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBA protein]
acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]]
CTD PMID:23270704 PMID:29037473 NCBI chr 8:123,151,510...123,159,679
Ensembl chr 8:123,151,515...123,159,669
JBrowse link
G Cybb cytochrome b-245, beta polypeptide multiple interactions ISO acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYBB mRNA]; acetovanillone inhibits the reaction [Glucose results in increased expression of and results in increased activity of CYBB protein]
acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBB mRNA]; acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBB protein]; acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of CYBB mRNA]
CTD PMID:19878672 PMID:23270704 PMID:24080574 PMID:30797899 NCBI chr  X:9,301,493...9,354,005
Ensembl chr  X:9,301,491...9,354,010
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO acetovanillone inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of CYCS protein] CTD PMID:36988283 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518
JBrowse link
G Des desmin multiple interactions EXP acetovanillone inhibits the reaction [Homocysteine results in increased expression of DES mRNA]; acetovanillone inhibits the reaction [Homocysteine results in increased expression of DES protein] CTD PMID:20036696 NCBI chr 1:75,336,936...75,345,223
Ensembl chr 1:75,336,973...75,345,223
JBrowse link
G Dmd dystrophin, muscular dystrophy multiple interactions EXP acetovanillone inhibits the reaction [DMD gene mutant form results in increased expression of RELA protein modified form]; acetovanillone inhibits the reaction [DMD gene mutant form results in increased expression of SIRT1 mRNA] CTD PMID:26930420 NCBI chr  X:81,858,244...84,248,656
Ensembl chr  X:81,992,476...84,249,747
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP
ISO
acetovanillone inhibits the reaction [AGT protein results in increased expression of EDN1 mRNA]
[polyethylene glycol-superoxide dismutase co-treated with acetovanillone] inhibits the reaction [EDN1 protein results in increased expression of and results in increased cleavage of PARP1 protein]; acetovanillone inhibits the reaction [EDN1 protein results in decreased susceptibility to Acetylcholine]; acetovanillone inhibits the reaction [EDN1 protein results in increased abundance of Reactive Oxygen Species]
CTD PMID:17391658 PMID:20977430 PMID:22431579 PMID:24932781 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466
JBrowse link
G Ednra endothelin receptor type A multiple interactions ISO acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA mRNA]; acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA protein] CTD PMID:23270704 NCBI chr 8:78,389,658...78,451,081
Ensembl chr 8:78,389,660...78,451,093
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO acetovanillone inhibits the reaction [Cadmium results in increased phosphorylation of EGFR protein] CTD PMID:26514923 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of EIF2AK3 mRNA]; acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of EIF2AK3 protein] CTD PMID:23270704 NCBI chr 6:70,821,468...70,882,225
Ensembl chr 6:70,821,499...70,882,229
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO acetovanillone inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]] CTD PMID:19281832 NCBI chr15:81,470,329...81,536,273
Ensembl chr15:81,469,552...81,536,278
JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha multiple interactions EXP acetovanillone inhibits the reaction [arsenite results in increased expression of ERO1A protein] CTD PMID:37659621 NCBI chr14:45,520,544...45,556,029
Ensembl chr14:45,520,544...45,556,228
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO acetovanillone inhibits the reaction [Gentamicins results in increased expression of FAS protein] CTD PMID:28116922 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO acetovanillone inhibits the reaction [Glucose results in increased secretion of FN1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of FN1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of FN1 mRNA]
acetovanillone inhibits the reaction [Glucose results in increased expression of FN1 protein]
CTD PMID:15086456 PMID:16632126 PMID:22245600 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359
JBrowse link
G Fshb follicle stimulating hormone beta multiple interactions ISO acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of FSHB protein] CTD PMID:23270704 NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001
JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions EXP acetovanillone inhibits the reaction [Ketamine results in decreased expression of GAD1 protein] CTD PMID:18063801 NCBI chr 2:70,392,109...70,432,358
Ensembl chr 2:70,383,416...70,432,358
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of GFAP protein] CTD PMID:30797899 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO acetovanillone inhibits the reaction [Oxygen deficiency results in decreased expression of GJA1 mRNA]; acetovanillone inhibits the reaction [Oxygen deficiency results in decreased expression of GJA1 protein] CTD PMID:23270704 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609
JBrowse link
G Glo1 glyoxalase 1 multiple interactions EXP acetovanillone inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein] CTD PMID:25042521 NCBI chr17:30,811,835...30,831,633
Ensembl chr17:30,803,910...30,845,845
JBrowse link
G Gna11 guanine nucleotide binding protein, alpha 11 multiple interactions ISO acetovanillone inhibits the reaction [Glucose results in increased expression of GNA11 protein]; acetovanillone inhibits the reaction [Streptozocin results in increased expression of GNA11 protein] CTD PMID:20691780 NCBI chr10:81,364,558...81,380,996
Ensembl chr10:81,364,558...81,381,024
JBrowse link
G Gnaq guanine nucleotide binding protein, alpha q polypeptide multiple interactions ISO acetovanillone inhibits the reaction [Glucose results in increased expression of GNAQ protein]; acetovanillone inhibits the reaction [Streptozocin results in increased expression of GNAQ protein] CTD PMID:20691780 NCBI chr19:16,110,048...16,365,884
Ensembl chr19:16,110,195...16,364,827
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO
EXP
acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of GPX1 protein]; acetovanillone inhibits the reaction [Pyrogallol results in increased activity of GPX1 protein]
acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]]; acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]]; acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]]; acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein]]
CTD PMID:22431579 PMID:29037473 PMID:35944648 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542
JBrowse link
G Gpx3 glutathione peroxidase 3 multiple interactions ISO acetovanillone inhibits the reaction [Formaldehyde results in increased expression of GPX3 mRNA] CTD PMID:21983654 NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions EXP acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of GPX4 protein] CTD PMID:30797899 NCBI chr10:79,883,000...79,892,273
Ensembl chr10:79,883,000...79,892,273
JBrowse link
G Gsdmd gasdermin D multiple interactions ISO acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased cleavage of GSDMD protein] CTD PMID:30378427 NCBI chr15:75,733,990...75,739,257
Ensembl chr15:75,734,176...75,739,257
JBrowse link
G Gucy1a1 guanylate cyclase 1, soluble, alpha 1 increases expression ISO acetovanillone results in increased expression of GUCY1A1 protein CTD PMID:25217652 NCBI chr 3:81,999,734...82,053,253
Ensembl chr 3:81,999,734...82,053,096
JBrowse link
G Gucy1b1 guanylate cyclase 1, soluble, beta 1 increases expression ISO acetovanillone results in increased expression of GUCY1B1 protein CTD PMID:25217652 NCBI chr 3:81,939,311...81,982,018
Ensembl chr 3:81,939,313...81,981,996
JBrowse link
G Gypa glycophorin A multiple interactions ISO acetovanillone inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GYPA protein] CTD PMID:20523355 NCBI chr 8:81,220,674...81,237,414
Ensembl chr 8:81,220,410...81,237,171
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit increases expression
multiple interactions
ISO acetovanillone results in increased expression of HIF1A protein
acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]
CTD PMID:12595275 PMID:23144690 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO acetovanillone inhibits the reaction [Ethanol results in increased secretion of HMGB1 protein] CTD PMID:26079697 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression
ISO
EXP
acetovanillone inhibits the reaction [Cadmium Chloride results in increased activity of HMOX1 protein]; acetovanillone inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; acetovanillone inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]; acetovanillone inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 protein]; acetovanillone inhibits the reaction [sodium arsenite results in increased expression of HMOX1 protein]
acetovanillone inhibits the reaction [Cisplatin results in increased expression of HMOX1 mRNA]
acetovanillone results in decreased expression of HMOX1 mRNA
CTD PMID:19414066 PMID:20934533 PMID:21690482 PMID:24291008 PMID:26945724 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Htr1a 5-hydroxytryptamine (serotonin) receptor 1A multiple interactions EXP acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to HTR1A protein]]; acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [PRKCD protein binds to HTR1A protein]]; acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of HTR1A mRNA]; acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of HTR1A protein] CTD PMID:30366073 NCBI chr13:105,580,040...105,584,630
Ensembl chr13:105,580,147...105,584,630
JBrowse link
G Htra2 HtrA serine peptidase 2 multiple interactions ISO [tempol co-treated with UCF 101 co-treated with acetovanillone] inhibits the reaction [S-Nitrosoglutathione affects the localization of HTRA2 protein] CTD PMID:20153346 NCBI chr 6:83,028,247...83,031,552
Ensembl chr 6:83,028,247...83,032,254
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression
ISO
EXP
acetovanillone inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of ICAM1 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]; acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased expression of ICAM1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
acetovanillone inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]
acetovanillone results in decreased expression of ICAM1 protein
CTD PMID:10495789 PMID:19417757 PMID:19632255 PMID:20920494 PMID:22414048 More... NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
JBrowse link
G Ifnb1 interferon beta 1, fibroblast multiple interactions ISO acetovanillone inhibits the reaction [vanadium pentoxide results in increased expression of IFNB1 mRNA] CTD PMID:18322232 NCBI chr 4:88,440,253...88,441,083
Ensembl chr 4:88,440,262...88,441,011
JBrowse link
G Ifng interferon gamma multiple interactions ISO
EXP
acetovanillone results in decreased susceptibility to [IFNG protein co-treated with Lipopolysaccharides]
acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of IFNG protein]
CTD PMID:16307444 PMID:30366073 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
JBrowse link
G Il18 interleukin 18 multiple interactions EXP acetovanillone analog inhibits the reaction [manganese chloride results in increased expression of IL18 mRNA] CTD PMID:28539244 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases response to substance
EXP
ISO
acetovanillone analog inhibits the reaction [manganese chloride results in increased expression of IL1B mRNA]; acetovanillone inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of IL1B protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
acetovanillone inhibits the reaction [Asbestos, Crocidolite results in increased secretion of IL1B protein]; acetovanillone inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]]; acetovanillone inhibits the reaction [IL1B protein affects the localization of NCF1 protein]; acetovanillone inhibits the reaction [IL1B protein results in increased abundance of Reactive Oxygen Species]; acetovanillone inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; acetovanillone inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; acetovanillone inhibits the reaction [IL1B protein results in increased expression of RELA protein modified form]; acetovanillone inhibits the reaction [IL1B protein results in increased expression of VCAM1 mRNA]; acetovanillone inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased expression of IL1B protein]; acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased secretion of IL1B protein modified form]
acetovanillone results in decreased susceptibility to IL1B protein
acetovanillone inhibits the reaction [Ethanol results in increased expression of IL1B protein]; acetovanillone inhibits the reaction [Formaldehyde results in increased expression of IL1B protein]
CTD PMID:18403674 PMID:19005069 PMID:19281832 PMID:21211511 PMID:21983654 More... NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO
acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of IL6 protein]; acetovanillone inhibits the reaction [cobaltous chloride results in increased expression of IL6 protein]; acetovanillone inhibits the reaction [di-n-butyltin results in increased expression of IL6 mRNA]; acetovanillone inhibits the reaction [di-n-butyltin results in increased expression of IL6 protein]; acetovanillone inhibits the reaction [Pyruvaldehyde results in increased expression of IL6 protein]
acetovanillone inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of IL6 protein]
acetovanillone inhibits the reaction [Formaldehyde results in increased expression of IL6 protein]; acetovanillone inhibits the reaction [Mitogens results in increased expression of IL6 protein]; acetovanillone inhibits the reaction [Pyrogallol results in increased expression of IL6 protein]; acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of IL6 protein]]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of IL6 protein]]
CTD PMID:21983654 PMID:22414048 PMID:22472292 PMID:24631921 PMID:25042521 More... NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Ins1 insulin I multiple interactions ISO acetovanillone inhibits the reaction [Mitogens results in increased secretion of INS1 protein]; acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased secretion of INS1 protein]]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased secretion of INS1 protein]] CTD PMID:29760339 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914
JBrowse link
G Itga2b integrin alpha 2b multiple interactions ISO acetovanillone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGA2B protein] CTD PMID:20523355 NCBI chr11:102,344,134...102,360,570
Ensembl chr11:102,344,123...102,360,948
JBrowse link
G Itgam integrin alpha M multiple interactions ISO
EXP
acetovanillone inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of ITGAM mRNA]
acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of ITGAM protein]; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of ITGAM protein]
CTD PMID:16357311 PMID:28202386 PMID:30797899 NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663
JBrowse link
G Itgb3 integrin beta 3 multiple interactions ISO acetovanillone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein] CTD PMID:20523355 NCBI chr11:104,498,826...104,561,302
Ensembl chr11:104,498,826...104,561,302
JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO acetovanillone inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]] CTD PMID:15677497 NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480
JBrowse link
G Jun jun proto-oncogene multiple interactions ISO acetovanillone inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of and results in increased expression of JUN protein]; acetovanillone inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of JUN mRNA]; acetovanillone inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of JUN protein] CTD PMID:22288910 PMID:36988283 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
JBrowse link
G Lep leptin multiple interactions EXP acetovanillone inhibits the reaction [LEP protein affects the abundance of Calcium]; acetovanillone inhibits the reaction [LEP protein results in increased abundance of Superoxides]; acetovanillone inhibits the reaction [LEP protein results in increased expression of NCF1 protein]; acetovanillone inhibits the reaction [LEP protein results in increased expression of NCF2 protein] CTD PMID:16380530 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876
JBrowse link
G Lepr leptin receptor multiple interactions EXP acetovanillone inhibits the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine]; acetovanillone inhibits the reaction [LEPR gene mutant form results in increased abundance of Superoxides] CTD PMID:19478208 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549
JBrowse link
G Lhb luteinizing hormone beta multiple interactions ISO acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of LHB protein] CTD PMID:23270704 NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321
JBrowse link
G Lpo lactoperoxidase multiple interactions ISO acetovanillone inhibits the reaction [Pyrogallol results in increased activity of LPO protein] CTD PMID:35944648 NCBI chr11:87,697,254...87,716,750
Ensembl chr11:87,697,254...87,719,115
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO acetovanillone analog inhibits the reaction [Chlorpyrifos results in increased lipidation of MAP1LC3B protein] CTD PMID:29859868 NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions EXP
ISO
acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]
acetovanillone inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]
acetovanillone inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]
CTD PMID:16632126 PMID:20354174 PMID:21391979 PMID:22288910 PMID:23774252 More... NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions EXP
ISO
acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased phosphorylation of MAPK3 protein]; acetovanillone inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
acetovanillone inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK3 protein]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]
acetovanillone inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of MAPK3 protein]; acetovanillone inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK3 protein]; acetovanillone inhibits the reaction [Cadmium results in increased phosphorylation of MAPK3 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]
CTD PMID:16632126 PMID:20354174 PMID:21391979 PMID:22288910 PMID:23774252 More... NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP
ISO
acetovanillone inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK8 protein]
acetovanillone inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK8 protein]; acetovanillone inhibits the reaction [Cadmium results in increased phosphorylation of MAPK8 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]; acetovanillone inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of MAPK8 mRNA]; acetovanillone inhibits the reaction [perfluorooctane sulfonic acid results in increased phosphorylation of MAPK8 protein]
CTD PMID:20354174 PMID:21391979 PMID:24967690 PMID:26514923 PMID:36988283 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO acetovanillone inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK9 protein]; acetovanillone inhibits the reaction [Cadmium results in increased phosphorylation of MAPK9 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein] CTD PMID:21391979 PMID:24967690 PMID:26514923 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248
JBrowse link
G Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in increased expression of MIF mRNA] CTD PMID:22414048 NCBI chr10:75,695,187...75,696,111
Ensembl chr10:75,695,187...75,696,074
JBrowse link
G Mlkl mixed lineage kinase domain-like multiple interactions ISO acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased expression of MLKL protein] CTD PMID:30378427 NCBI chr 8:112,037,879...112,065,081
Ensembl chr 8:112,038,429...112,064,809
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO acetovanillone inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of MMP13 protein] CTD PMID:21211511 NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of MMP9 mRNA]; acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of MMP9 protein]; acetovanillone inhibits the reaction [RELA protein binds to MMP9 promoter]; acetovanillone inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]
acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of MMP9 mRNA]
CTD PMID:23270704 PMID:23774252 PMID:26514923 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
JBrowse link
G Mpo myeloperoxidase decreases expression
multiple interactions
EXP
ISO
acetovanillone results in decreased expression of MPO protein
acetovanillone inhibits the reaction [Cisplatin results in increased activity of MPO protein]
CTD PMID:19417757 PMID:24291008 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
JBrowse link
G Msr1 macrophage scavenger receptor 1 multiple interactions ISO acetovanillone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA] CTD PMID:9614211 NCBI chr 8:39,996,284...40,095,790
Ensembl chr 8:40,034,726...40,095,714
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions EXP
ISO
acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to HTR1A protein]]; acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to PRKCD protein]]; acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]]; acetovanillone inhibits the reaction [LEP protein results in increased expression of NCF1 protein]
acetovanillone inhibits the reaction [2,2',4,6,6'-pentachlorobiphenyl results in increased phosphorylation of NCF1 protein]; acetovanillone inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased phosphorylation of NCF1 protein]; acetovanillone inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of NCF1 protein]; acetovanillone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased phosphorylation of NCF1 protein]; acetovanillone inhibits the reaction [Arsenic Trioxide affects the localization of NCF1 protein]; acetovanillone inhibits the reaction [Glucose results in increased expression of and results in increased activity of NCF1 protein]; acetovanillone inhibits the reaction [IL1B protein affects the localization of NCF1 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides affects the localization of NCF1 protein]; acetovanillone inhibits the reaction [N-Methylaspartate affects the localization of NCF1 protein]
acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of NCF1 mRNA]; acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of NCF1 protein]; acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of NCF1 mRNA]
CTD PMID:16380530 PMID:18424721 PMID:19281832 PMID:19878672 PMID:20299304 More... NCBI chr 5:134,248,907...134,258,479
Ensembl chr 5:134,248,907...134,258,479
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 multiple interactions EXP
ISO
acetovanillone inhibits the reaction [LEP protein results in increased expression of NCF2 protein]
acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of NCF2 mRNA]
CTD PMID:16380530 PMID:24080574 NCBI chr 1:152,675,904...152,712,743
Ensembl chr 1:152,675,945...152,712,742
JBrowse link
G Nfatc1 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 multiple interactions ISO acetovanillone inhibits the reaction [[sodium arsenite results in increased abundance of arsenite] which affects the localization of NFATC1 protein] CTD PMID:22564430 NCBI chr18:80,649,418...80,756,286
Ensembl chr18:80,649,420...80,756,286
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO acetovanillone inhibits the reaction [Cisplatin results in increased expression of NFE2L2 mRNA]
[acetovanillone co-treated with AGT protein] results in increased expression of and affects the localization of NFE2L2 protein
CTD PMID:24291008 PMID:27983965 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO
EXP
acetovanillone inhibits the reaction [Homocysteine results in increased phosphorylation of and results in increased activity of NFKBIA protein]
acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased phosphorylation of and results in decreased expression of NFKBIA protein]; acetovanillone inhibits the reaction [Glucose results in increased phosphorylation of NFKBIA protein]
CTD PMID:16845898 PMID:17065336 PMID:28202386 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and results in decreased ubiquitination of NLRP3 protein] CTD PMID:26901245 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO
EXP
acetovanillone inhibits the reaction [Ethanol results in increased expression of NOS2 protein]; acetovanillone inhibits the reaction [Formaldehyde results in increased expression of NOS2 mRNA]
acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NOS2 mRNA]; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]
CTD PMID:21983654 PMID:26522475 PMID:28202386 PMID:30797899 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell multiple interactions
increases expression
ISO acetovanillone inhibits the reaction [Glucose results in decreased expression of NOS3 protein]
[Cadmium co-treated with acetovanillone] results in increased expression of NOS3 protein; acetovanillone inhibits the reaction [Formaldehyde results in increased expression of NOS3 mRNA]
acetovanillone results in increased expression of NOS3 protein
CTD PMID:19878672 PMID:21983654 PMID:23703608 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions ISO acetovanillone inhibits the reaction [Ethanol results in increased expression of NOX1 protein]; acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]; acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]]
acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOX1 mRNA]
CTD PMID:26522475 PMID:29760339 PMID:30797899 NCBI chr  X:132,987,170...133,038,455
Ensembl chr  X:132,987,170...133,122,705
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO [acetovanillone co-treated with CAT protein] inhibits the reaction [Cyclosporine results in increased expression of NOX4 mRNA]; acetovanillone inhibits the reaction [Cyclosporine results in increased expression of NOX4 mRNA]; acetovanillone inhibits the reaction [Ethanol results in increased expression of NOX4 protein]; acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]; acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]]
acetovanillone inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of NOX4 mRNA]; acetovanillone inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of NOX4 protein]
CTD PMID:26522475 PMID:29760339 PMID:32298299 PMID:36988283 NCBI chr 7:86,893,638...87,047,918
Ensembl chr 7:86,895,304...87,047,918
JBrowse link
G Noxa1 NADPH oxidase activator 1 multiple interactions ISO acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of NOXA1 mRNA] CTD PMID:24080574 NCBI chr 2:24,975,679...24,985,217
Ensembl chr 2:24,975,679...24,985,161
JBrowse link
G Noxo1 NADPH oxidase organizer 1 multiple interactions ISO acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of NOXO1 mRNA] CTD PMID:24080574 NCBI chr17:24,915,208...24,919,504
Ensembl chr17:24,915,208...24,919,503
JBrowse link
G Nphs1 nephrosis 1, nephrin multiple interactions EXP acetovanillone inhibits the reaction [Homocysteine results in decreased expression of NPHS1 mRNA]; acetovanillone inhibits the reaction [Homocysteine results in decreased expression of NPHS1 protein] CTD PMID:20036696 NCBI chr 7:30,157,259...30,188,048
Ensembl chr 7:30,157,740...30,186,648
JBrowse link
G Nphs2 nephrosis 2, podocin multiple interactions EXP acetovanillone inhibits the reaction [Homocysteine results in decreased expression of NPHS2 mRNA]; acetovanillone inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein] CTD PMID:20036696 NCBI chr 1:156,138,105...156,155,605
Ensembl chr 1:156,138,297...156,155,605
JBrowse link
G Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 multiple interactions ISO acetovanillone inhibits the reaction [Glucose results in increased expression of OLR1 mRNA] CTD PMID:19878672 NCBI chr 6:129,456,113...129,484,312
Ensembl chr 6:129,462,207...129,484,128
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions EXP
ISO
acetovanillone inhibits the reaction [AGT protein results in increased activity of PARP1 protein]; acetovanillone inhibits the reaction [zinc chloride results in increased activity of PARP1 protein]
[polyethylene glycol-superoxide dismutase co-treated with acetovanillone] inhibits the reaction [EDN1 protein results in increased expression of and results in increased cleavage of PARP1 protein]
acetovanillone inhibits the reaction [arsenite results in increased oxidation of PARP1 protein]; acetovanillone inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of PARP1 protein]
CTD PMID:15502880 PMID:18509044 PMID:24932781 PMID:29111459 PMID:34798142 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO acetovanillone inhibits the reaction [Ozone results in increased expression of PCNA protein] CTD PMID:9517619 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
JBrowse link
G Plcb1 phospholipase C, beta 1 multiple interactions ISO acetovanillone inhibits the reaction [Glucose results in increased expression of PLCB1 protein]; acetovanillone inhibits the reaction [Streptozocin results in increased expression of PLCB1 protein] CTD PMID:20691780 NCBI chr 2:134,628,084...135,317,178
Ensembl chr 2:134,627,987...135,317,178
JBrowse link
G Plcb2 phospholipase C, beta 2 multiple interactions ISO acetovanillone inhibits the reaction [Glucose results in increased expression of PLCB2 protein]; acetovanillone inhibits the reaction [Streptozocin results in increased expression of PLCB2 protein] CTD PMID:20691780 NCBI chr 2:118,535,484...118,559,140
Ensembl chr 2:118,537,998...118,558,919
JBrowse link
G Pomc pro-opiomelanocortin-alpha multiple interactions ISO acetovanillone inhibits the reaction [POMC protein affects the abundance of F2-Isoprostanes] CTD PMID:16053986 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642
JBrowse link
G Prkcd protein kinase C, delta multiple interactions EXP
ISO
acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to PRKCD protein]]; acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [PRKCD protein binds to HTR1A protein]]
acetovanillone analog inhibits the reaction [Chlorpyrifos results in increased cleavage of PRKCD protein]
CTD PMID:29859868 PMID:30366073 NCBI chr14:30,317,310...30,348,637
Ensembl chr14:30,317,311...30,348,167
JBrowse link
G Prkg1 protein kinase, cGMP-dependent, type I multiple interactions ISO acetovanillone inhibits the reaction [Glucose results in decreased expression of PRKG1 protein] CTD PMID:17320767 NCBI chr19:30,541,887...31,742,675
Ensembl chr19:30,541,889...31,742,433
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO acetovanillone inhibits the reaction [Formaldehyde results in increased expression of PTGS1 mRNA]; acetovanillone inhibits the reaction [Streptozocin results in increased expression of PTGS1 protein] CTD PMID:18414395 PMID:21983654 NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
ISO
EXP
acetovanillone inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]; acetovanillone inhibits the reaction [Ethanol results in increased expression of PTGS2 protein]; acetovanillone inhibits the reaction [Mercuric Chloride results in increased expression of PTGS2 mRNA]; acetovanillone inhibits the reaction [Pyrogallol results in increased expression of PTGS2 protein]; acetovanillone inhibits the reaction [Streptozocin results in increased expression of PTGS2 protein]
acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of PTGS2 protein]; acetovanillone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
acetovanillone inhibits the reaction [2-aminodiphenyl results in increased expression of PTGS2 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; acetovanillone inhibits the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]; acetovanillone inhibits the reaction [Particulate Matter results in increased expression of PTGS2 protein]
acetovanillone results in decreased expression of PTGS2 mRNA
CTD PMID:17244722 PMID:18414395 PMID:21983654 PMID:22288910 PMID:23415682 More... NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Ptk2b PTK2 protein tyrosine kinase 2 beta multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in decreased phosphorylation of PTK2B protein] CTD PMID:23774252 NCBI chr14:66,390,706...66,518,549
Ensembl chr14:66,390,706...66,518,501
JBrowse link
G Pvalb parvalbumin multiple interactions EXP acetovanillone inhibits the reaction [Ketamine results in decreased expression of PVALB protein] CTD PMID:18063801 NCBI chr15:78,075,312...78,090,600
Ensembl chr15:78,075,314...78,090,600
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO acetovanillone inhibits the reaction [Ethanol results in increased expression of PYCARD protein] CTD PMID:26079697 NCBI chr 7:127,590,545...127,593,039
Ensembl chr 7:127,588,880...127,593,039
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP
ISO
acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased phosphorylation of RELA protein]; acetovanillone inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of RELA protein]; acetovanillone inhibits the reaction [DMD gene mutant form results in increased expression of RELA protein modified form]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]
acetovanillone inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]]; acetovanillone inhibits the reaction [IL1B protein results in increased expression of RELA protein modified form]
acetovanillone inhibits the reaction [RELA protein binds to MMP9 promoter]; acetovanillone inhibits the reaction [TNF protein affects the localization of RELA protein]
CTD PMID:19281832 PMID:19608869 PMID:20354174 PMID:23774252 PMID:26930420 More... NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Runx2 runt related transcription factor 2 multiple interactions ISO acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of RUNX2 mRNA] CTD PMID:24080574 NCBI chr17:44,806,873...45,125,518
Ensembl chr17:44,806,874...45,125,684
JBrowse link
G S100a4 S100 calcium binding protein A4 multiple interactions EXP acetovanillone inhibits the reaction [Homocysteine results in increased expression of S100A4 protein] CTD PMID:21647593 NCBI chr 3:90,511,077...90,513,349
Ensembl chr 3:90,511,078...90,513,352
JBrowse link
G Sele selectin, endothelial cell multiple interactions ISO acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased expression of SELE protein] CTD PMID:26901245 NCBI chr 1:163,867,200...163,886,056
Ensembl chr 1:163,875,773...163,885,246
JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA] CTD PMID:22414048 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122
JBrowse link
G Shc1 src homology 2 domain-containing transforming protein C1 multiple interactions ISO acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of SHC1 mRNA]; acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of SHC1 protein] CTD PMID:23270704 NCBI chr 3:89,325,858...89,337,336
Ensembl chr 3:89,325,750...89,337,334
JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP acetovanillone inhibits the reaction [DMD gene mutant form results in increased expression of SIRT1 mRNA] CTD PMID:26930420 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483
JBrowse link
G Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 multiple interactions EXP acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of SLC40A1 protein] CTD PMID:30797899 NCBI chr 1:45,947,230...45,965,690
Ensembl chr 1:45,947,228...45,965,683
JBrowse link
G Snca synuclein, alpha multiple interactions ISO acetovanillone analog inhibits the reaction [Chlorpyrifos results in increased phosphorylation of SNCA protein] CTD PMID:29859868 NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839
JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions ISO
EXP
acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of SOD1 protein]; acetovanillone inhibits the reaction [Formaldehyde results in increased expression of SOD1 mRNA]
acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein]]
CTD PMID:21983654 PMID:22431579 PMID:29037473 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions ISO
EXP
acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of SOD2 protein]; acetovanillone inhibits the reaction [Formaldehyde results in increased expression of SOD2 mRNA]
acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]]
CTD PMID:21983654 PMID:22431579 PMID:29037473 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO acetovanillone inhibits the reaction [Hydrogen Peroxide deficiency results in decreased expression of STAR protein]; acetovanillone inhibits the reaction [Oxygen deficiency results in decreased expression of STAR mRNA]; acetovanillone inhibits the reaction [Oxygen deficiency results in decreased expression of STAR protein] CTD PMID:23270704 NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO acetovanillone inhibits the reaction [vanadium pentoxide results in increased phosphorylation of STAT1 protein]
acetovanillone analog inhibits the reaction [Chlorpyrifos results in increased expression of and results in increased phosphorylation of STAT1 protein]
CTD PMID:18322232 PMID:29859868 NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO acetovanillone inhibits the reaction [Mitogens results in increased expression of TGFB1 protein] CTD PMID:29760339 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Th tyrosine hydroxylase decreases expression
multiple interactions
ISO acetovanillone results in decreased expression of TH mRNA
acetovanillone analog inhibits the reaction [Chlorpyrifos results in decreased expression of TH protein]
CTD PMID:25217652 PMID:29859868 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO
EXP
acetovanillone inhibits the reaction [2,2',4,6,6'-pentachlorobiphenyl results in decreased expression of TJP1 protein]; acetovanillone inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in decreased expression of TJP1 protein]; acetovanillone inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of TJP1 protein]; acetovanillone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TJP1 protein]
acetovanillone inhibits the reaction [Homocysteine results in decreased expression of TJP1 protein]
CTD PMID:20299304 PMID:21647593 NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases response to substance
ISO
EXP
acetovanillone inhibits the reaction [tert-Butylhydroperoxide results in increased secretion of TNF protein]; acetovanillone inhibits the reaction [TNF protein results in increased abundance of Hydrogen Peroxide]; acetovanillone inhibits the reaction [TNF protein results in increased abundance of Superoxides]; acetovanillone inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of FN1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL7 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CSF2 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL1 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL10 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of FN1 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of IL6 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of MIF mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of MMP13 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]
acetovanillone inhibits the reaction [Cisplatin results in increased expression of TNF protein]; acetovanillone inhibits the reaction [Ethanol results in increased expression of TNF protein]; acetovanillone inhibits the reaction [Mitogens results in increased expression of TNF protein]; acetovanillone inhibits the reaction [TNF protein affects the localization of RELA protein]; acetovanillone inhibits the reaction [TNF protein results in decreased phosphorylation of PTK2B protein]; acetovanillone inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]; acetovanillone inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]; acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TNF protein]]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of TNF protein]]
acetovanillone results in decreased susceptibility to TNF protein
acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNF mRNA]; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; acetovanillone inhibits the reaction [cobaltous chloride results in increased expression of TNF protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; acetovanillone inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]
CTD PMID:10495789 PMID:15795323 PMID:16632126 PMID:19608869 PMID:21211511 More... NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Traf6 TNF receptor-associated factor 6 multiple interactions ISO Apocynin inhibits the reaction [hydrogen peroxide increases expression of Traf6 protein in rat neonatal cardiomyocytes] RGD PMID:27249171 RGD:155646134 NCBI chr 2:101,508,765...101,532,013
Ensembl chr 2:101,508,774...101,532,014
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of TP53 protein] CTD PMID:22431579 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO acetovanillone inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of VCAM1 protein]; acetovanillone inhibits the reaction [IL1B protein results in increased expression of VCAM1 mRNA]; acetovanillone inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased expression of VCAM1 protein] CTD PMID:19281832 PMID:19632255 PMID:26901245 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO acetovanillone inhibits the reaction [Cocaine results in increased activity of XDH protein] CTD PMID:17217956 NCBI chr17:74,190,890...74,257,191
Ensembl chr17:74,190,890...74,257,191
JBrowse link
butan-2-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacng6 calcium channel, voltage-dependent, gamma subunit 6 decreases expression ISO methylethyl ketone results in decreased expression of CACNG6 mRNA CTD PMID:33064461 NCBI chr 7:3,472,017...3,484,183
Ensembl chr 7:3,472,711...3,484,183
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects response to substance ISO CYP2E1 gene mutant form affects the susceptibility to methylethyl ketone CTD PMID:21352904 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
JBrowse link
G Glud1 glutamate dehydrogenase 1 multiple interactions EXP
ISO
methylethyl ketone promotes the reaction [2-dichlorobenzene results in increased activity of GLUD1 protein] CTD PMID:2554539 NCBI chr14:34,032,684...34,066,990
Ensembl chr14:34,032,684...34,067,222
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha increases expression ISO methylethyl ketone results in increased expression of PPARGC1A mRNA CTD PMID:33064461 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068
JBrowse link
G Srsf2 serine and arginine-rich splicing factor 2 decreases expression ISO methylethyl ketone results in decreased expression of SRSF2 mRNA CTD PMID:33064461 NCBI chr11:116,740,723...116,744,511
Ensembl chr11:116,740,727...116,743,920
JBrowse link
buten-2-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO [3-buten-2-one results in increased metabolism of APP protein] which results in increased secretion of APP protein modified form CTD PMID:29618714 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO 3-buten-2-one binds to and results in decreased activity of GAPDH protein CTD PMID:22084934 NCBI chr 6:125,138,812...125,143,450
Ensembl chr 6:125,138,678...125,143,430
JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions ISO [PTGR1 protein co-treated with NADP] affects the reduction of 3-buten-2-one CTD PMID:11524419 NCBI chr 4:58,965,590...58,987,131
Ensembl chr 4:58,965,439...58,987,119
JBrowse link
heptan-2-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gna15 guanine nucleotide binding protein, alpha 15 multiple interactions
increases response to substance
ISO [GNA15 protein results in increased susceptibility to 2-heptanone] which results in decreased activity of OR5G26 protein CTD PMID:15598656 NCBI chr10:81,338,147...81,360,283
Ensembl chr10:81,338,140...81,360,059
JBrowse link
G Gnal guanine nucleotide binding protein, alpha stimulating, olfactory type increases response to substance
multiple interactions
ISO GNAL protein results in increased susceptibility to 2-heptanone
[GNAL protein results in increased susceptibility to 2-heptanone] which results in increased activity of OR5G26 protein
CTD PMID:15598656 NCBI chr18:67,221,369...67,359,863
Ensembl chr18:67,221,287...67,359,863
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 decreases activity ISO 2-heptanone results in decreased activity of GSTP1 protein CTD PMID:18409811 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
JBrowse link
G Or5g26 olfactory receptor family 5 subfamily G member 26 increases activity EXP 2-heptanone results in increased activity of OR5G26 protein CTD PMID:15598656 NCBI chr 2:85,493,721...85,494,799
Ensembl chr 2:85,493,721...85,494,799
JBrowse link
G Or5g29 olfactory receptor family 5 subfamily G member 29 multiple interactions ISO [GNA15 protein results in increased susceptibility to 2-heptanone] which results in decreased activity of OR5G26 protein; [GNAL protein results in increased susceptibility to 2-heptanone] which results in increased activity of OR5G26 protein CTD PMID:15598656 NCBI chr 2:85,420,854...85,421,865
Ensembl chr 2:85,419,292...85,422,237
JBrowse link
iloperidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B member 11 decreases activity ISO iloperidone results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958
JBrowse link
mono(2-ethyl-5-oxohexyl) phthalate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acin1 apoptotic chromatin condensation inducer 1 affects expression ISO mono(2-ethyl-5-oxohexyl)phthalate affects the expression of ACIN1 mRNA CTD PMID:34478338 NCBI chr14:54,879,618...54,924,422
Ensembl chr14:54,879,618...54,924,388
JBrowse link
G Adam33 a disintegrin and metallopeptidase domain 33 multiple interactions ISO [[Endocrine Disruptors results in increased abundance of mono(2-ethyl-5-oxohexyl)phthalate] which results in increased methylation of ADAM33 intron] which results in increased expression of ADAM33 mRNA CTD PMID:30226539 NCBI chr 2:130,892,739...130,905,734
Ensembl chr 2:130,892,511...130,905,734
JBrowse link
G Ankrd10 ankyrin repeat domain 10 affects expression ISO mono(2-ethyl-5-oxohexyl)phthalate affects the expression of ANKRD10 mRNA CTD PMID:34478338 NCBI chr 8:11,661,581...11,694,617
Ensembl chr 8:11,661,583...11,685,757
JBrowse link
G Ap1g2 adaptor protein complex AP-1, gamma 2 subunit affects expression ISO mono(2-ethyl-5-oxohexyl)phthalate affects the expression of AP1G2 mRNA CTD PMID:34478338 NCBI chr14:55,336,292...55,344,050
Ensembl chr14:55,336,032...55,344,050
JBrowse link
G Arglu1 arginine and glutamate rich 1 affects expression ISO mono(2-ethyl-5-oxohexyl)phthalate affects the expression of ARGLU1 mRNA CTD PMID:34478338 NCBI chr 8:8,716,307...8,741,818
Ensembl chr 8:8,715,075...8,740,521
JBrowse link
G Ccdc163 coiled-coil domain containing 163 multiple interactions ISO [mono(2-ethyl-5-hydroxyhexyl) phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono(2-ethyl-5-oxohexyl)phthalate co-treated with 2-ethyl-5-carboxypentyl phthalate co-treated with mono-isobutyl phthalate co-treated with mono-benzyl phthalate co-treated with monoethyl phthalate co-treated with monobutyl phthalate] affects the expression of CCDC163 mRNA CTD PMID:37160244 NCBI chr 4:116,565,537...116,572,881
Ensembl chr 4:116,565,706...116,608,403
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO mono(2-ethyl-5-oxohexyl)phthalate results in decreased expression of CCL2 mRNA CTD PMID:32015430 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Ccnl1 cyclin L1 affects expression ISO mono(2-ethyl-5-oxohexyl)phthalate affects the expression of CCNL1 mRNA CTD PMID:34478338 NCBI chr 3:65,853,333...65,869,451
Ensembl chr 3:65,853,572...65,865,670
JBrowse link
G Cd68 CD68 antigen decreases expression ISO mono(2-ethyl-5-oxohexyl)phthalate results in decreased expression of CD68 mRNA CTD PMID:32015430 NCBI chr11:69,555,039...69,556,996
Ensembl chr11:69,555,039...69,556,979
JBrowse link
G Clk1 CDC-like kinase 1 affects expression ISO mono(2-ethyl-5-oxohexyl)phthalate affects the expression of CLK1 mRNA CTD PMID:34478338 NCBI chr 1:58,451,147...58,463,247
Ensembl chr 1:58,449,348...58,463,225
JBrowse link
G Crp C-reactive protein, pentraxin-related decreases expression ISO mono(2-ethyl-5-oxohexyl)phthalate results in decreased expression of CRP mRNA; mono(2-ethyl-5-oxohexyl)phthalate results in decreased expression of CRP protein CTD PMID:21349512 PMID:32015430 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598
JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 multiple interactions ISO [CYP2C6V1 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-oxohexyl)phthalate CTD PMID:22186153 PMID:23545481 NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157
JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 multiple interactions ISO [CYP2C19 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-oxohexyl)phthalate CTD PMID:22186153 NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 multiple interactions ISO [CYP2C9 protein polymorphism results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-oxohexyl)phthalate; [CYP2C9 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-oxohexyl)phthalate CTD PMID:22186153 PMID:23545481 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388
JBrowse link
G Dcakd dephospho-CoA kinase domain containing multiple interactions ISO [mono(2-ethyl-5-hydroxyhexyl) phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono(2-ethyl-5-oxohexyl)phthalate co-treated with 2-ethyl-5-carboxypentyl phthalate co-treated with mono-isobutyl phthalate co-treated with mono-benzyl phthalate co-treated with monoethyl phthalate co-treated with monobutyl phthalate] affects the expression of DCAKD mRNA CTD PMID:37160244 NCBI chr11:102,884,873...102,919,107
Ensembl chr11:102,884,873...102,919,159
JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO [Diethylhexyl Phthalate results in increased abundance of mono(2-ethyl-5-oxohexyl)phthalate] which results in increased expression of ESR1 protein CTD PMID:38042133 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
JBrowse link
G Flg filaggrin multiple interactions ISO [FLG gene polymorphism affects the susceptibility to Diethylhexyl Phthalate] which affects the abundance of mono(2-ethyl-5-oxohexyl)phthalate CTD PMID:24380925 NCBI chr 3:93,180,853...93,200,996
Ensembl chr 3:93,180,830...93,200,993
JBrowse link
G Igf2os insulin-like growth factor 2, opposite strand affects expression ISO mono(2-ethyl-5-oxohexyl)phthalate affects the expression of IGF2-AS mRNA CTD PMID:29385630 NCBI chr 7:142,213,417...142,224,093
Ensembl chr 7:142,213,430...142,224,093
JBrowse link
G Jak3 Janus kinase 3 multiple interactions ISO [Diethylhexyl Phthalate results in increased abundance of mono(2-ethyl-5-oxohexyl)phthalate] which results in increased expression of JAK3 mRNA CTD PMID:37093692 NCBI chr 8:72,129,027...72,143,221
Ensembl chr 8:72,128,940...72,143,219
JBrowse link
G Leng8 leukocyte receptor cluster (LRC) member 8 affects expression ISO mono(2-ethyl-5-oxohexyl)phthalate affects the expression of LENG8 mRNA CTD PMID:34478338 NCBI chr 7:4,140,014...4,151,176
Ensembl chr 7:4,140,038...4,151,176
JBrowse link
G Luc7l3 LUC7-like 3 (S. cerevisiae) affects expression ISO mono(2-ethyl-5-oxohexyl)phthalate affects the expression of LUC7L3 mRNA CTD PMID:34478338 NCBI chr11:94,181,899...94,213,196
Ensembl chr11:94,178,716...94,212,814
JBrowse link
G Mirlet7c-1 microRNA let7c-1 multiple interactions ISO [Diethylhexyl Phthalate results in increased abundance of mono(2-ethyl-5-oxohexyl)phthalate] which affects the expression of MIRLET7C CTD PMID:30481674 NCBI chr16:77,396,545...77,396,638
Ensembl chr16:77,396,545...77,396,638
JBrowse link
G Mmp1b matrix metallopeptidase 1b (interstitial collagenase) increases expression ISO mono(2-ethyl-5-oxohexyl)phthalate results in increased expression of MMP1 protein CTD PMID:36113809 NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression ISO mono(2-ethyl-5-oxohexyl)phthalate results in increased expression of MMP2 protein CTD PMID:36113809 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
JBrowse link
G Neat1 nuclear paraspeckle assembly transcript 1 (non-protein coding) affects expression ISO mono(2-ethyl-5-oxohexyl)phthalate affects the expression of NEAT1 mRNA CTD PMID:34478338 NCBI chr19:5,874,736...5,895,508
Ensembl chr19:5,874,736...5,895,898
JBrowse link
G Nefl neurofilament, light polypeptide multiple interactions ISO [Diethylhexyl Phthalate results in increased abundance of mono(2-ethyl-5-oxohexyl)phthalate] which results in increased expression of NEFL protein CTD PMID:37097562 NCBI chr14:68,321,312...68,326,544
Ensembl chr14:68,321,312...68,326,544
JBrowse link
G Nkx2-1 NK2 homeobox 1 multiple interactions ISO [Diethylhexyl Phthalate results in increased abundance of mono(2-ethyl-5-oxohexyl)phthalate] which results in increased expression of NKX2-1 mRNA CTD PMID:34708313 NCBI chr12:56,578,741...56,583,570
Ensembl chr12:56,578,743...56,583,693
JBrowse link
G Pfas phosphoribosylformylglycinamidine synthase (FGAR amidotransferase) multiple interactions ISO [mono(2-ethyl-5-hydroxyhexyl) phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono(2-ethyl-5-oxohexyl)phthalate co-treated with 2-ethyl-5-carboxypentyl phthalate co-treated with mono-isobutyl phthalate co-treated with mono-benzyl phthalate co-treated with monoethyl phthalate co-treated with monobutyl phthalate] affects the expression of PFAS mRNA CTD PMID:37160244 NCBI chr11:68,876,527...68,899,286
Ensembl chr11:68,876,523...68,899,286
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases activity ISO mono(2-ethyl-5-oxohexyl)phthalate results in increased activity of PPARA protein CTD PMID:28571686 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions ISO [Diethylhexyl Phthalate results in increased abundance of mono(2-ethyl-5-oxohexyl)phthalate] which results in decreased methylation of PPARG promoter; [Diethylhexyl Phthalate results in increased abundance of mono(2-ethyl-5-oxohexyl)phthalate] which results in increased expression of PPARG mRNA; mono(2-ethyl-5-oxohexyl)phthalate binds to and affects the folding of and results in increased activity of PPARG protein CTD PMID:30085373 PMID:37093692 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
JBrowse link
G Rbm6 RNA binding motif protein 6 affects expression ISO mono(2-ethyl-5-oxohexyl)phthalate affects the expression of RBM6 mRNA CTD PMID:34478338 NCBI chr 9:107,650,758...107,751,028
Ensembl chr 9:107,650,758...107,750,436
JBrowse link
G Shbg sex hormone binding globulin decreases secretion ISO mono(2-ethyl-5-oxohexyl)phthalate results in decreased secretion of SHBG protein CTD PMID:24945889 NCBI chr11:69,501,108...69,508,852
Ensembl chr11:69,505,630...69,508,731
JBrowse link
G Son Son DNA binding protein affects expression ISO mono(2-ethyl-5-oxohexyl)phthalate affects the expression of SON mRNA CTD PMID:34478338 NCBI chr16:91,444,712...91,476,080
Ensembl chr16:91,444,394...91,476,109
JBrowse link
G Srsf11 serine and arginine-rich splicing factor 11 affects expression ISO mono(2-ethyl-5-oxohexyl)phthalate affects the expression of SRSF11 mRNA CTD PMID:34478338 NCBI chr 3:157,716,552...157,742,304
Ensembl chr 3:157,716,110...157,742,276
JBrowse link
G Stat5b signal transducer and activator of transcription 5B multiple interactions ISO [Diethylhexyl Phthalate results in increased abundance of mono(2-ethyl-5-oxohexyl)phthalate] which results in decreased methylation of STAT5B promoter; [Diethylhexyl Phthalate results in increased abundance of mono(2-ethyl-5-oxohexyl)phthalate] which results in increased expression of STAT5B mRNA CTD PMID:37093692 NCBI chr11:100,671,557...100,741,407
Ensembl chr11:100,671,557...100,741,550
JBrowse link
G Tshb thyroid stimulating hormone, beta subunit multiple interactions ISO [Diethylhexyl Phthalate results in increased abundance of mono(2-ethyl-5-oxohexyl)phthalate] which results in decreased secretion of TSHB protein CTD PMID:29734584 NCBI chr 3:102,684,621...102,718,175
Ensembl chr 3:102,682,781...102,690,034
JBrowse link
G Tubgcp6 tubulin, gamma complex component 6 affects expression ISO mono(2-ethyl-5-oxohexyl)phthalate affects the expression of TUBGCP6 mRNA CTD PMID:34478338 NCBI chr15:88,983,300...89,007,411
Ensembl chr15:88,982,560...89,007,315
JBrowse link
nabumetone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO nabumetone results in decreased expression of BCL2 protein CTD PMID:16019514 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression ISO nabumetone results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO nabumetone results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity ISO nabumetone metabolite results in decreased activity of PTGS1 protein CTD PMID:9258749 NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases activity ISO nabumetone metabolite results in decreased activity of PTGS2 protein CTD PMID:9258749 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Sell selectin, lymphocyte affects expression ISO nabumetone affects the expression of SELL protein CTD PMID:12147693 NCBI chr 1:163,889,556...163,908,354
Ensembl chr 1:163,889,551...163,911,750
JBrowse link
G Utrn utrophin increases expression ISO nabumetone results in increased expression of UTRN mRNA; nabumetone results in increased expression of UTRN protein CTD PMID:22028826 NCBI chr10:12,257,931...12,745,632
Ensembl chr10:12,257,932...12,745,109
JBrowse link
pentane-2,3-dione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam10 a disintegrin and metallopeptidase domain 10 increases expression ISO 2,3-pentanedione results in increased expression of ADAM10 mRNA CTD PMID:25710175 NCBI chr 9:70,586,133...70,687,511
Ensembl chr 9:70,586,279...70,687,511
JBrowse link
G Adam19 ADAM metallopeptidase domain 19 increases expression ISO 2,3-pentanedione results in increased expression of ADAM19 mRNA CTD PMID:25710175 NCBI chr11:45,945,329...46,038,174
Ensembl chr11:45,946,819...46,038,170
JBrowse link
G Adam8 a disintegrin and metallopeptidase domain 8 decreases expression ISO 2,3-pentanedione results in decreased expression of ADAM8 mRNA CTD PMID:25710175 NCBI chr 7:139,558,845...139,573,016
Ensembl chr 7:139,558,845...139,572,475
JBrowse link
G Akap5 A kinase anchor protein 5 increases expression ISO 2,3-pentanedione results in increased expression of AKAP5 mRNA CTD PMID:25710175 NCBI chr12:76,371,652...76,380,925
Ensembl chr12:76,371,665...76,380,927
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B increases reduction
multiple interactions
ISO AKR1B1 protein results in increased reduction of 2,3-pentanedione
[AKR1B1 protein results in increased reduction of 2,3-pentanedione] which results in increased chemical synthesis of Pentanones
CTD PMID:23295224 NCBI chr 6:34,280,865...34,294,424
Ensembl chr 6:34,279,369...34,294,413
JBrowse link
G Akr1b10 aldo-keto reductase family 1, member B10 increases reduction
multiple interactions
ISO AKR1B10 protein results in increased reduction of 2,3-pentanedione
[AKR1B10 protein results in increased reduction of 2,3-pentanedione] which results in increased chemical synthesis of Pentanones
CTD PMID:23295224 NCBI chr 6:34,361,182...34,373,884
Ensembl chr 6:34,361,153...34,373,885
JBrowse link
G Aldh1a3 aldehyde dehydrogenase family 1, subfamily A3 increases expression ISO 2,3-pentanedione results in increased expression of ALDH1A3 mRNA CTD PMID:30710127 NCBI chr 7:66,040,640...66,077,225
Ensembl chr 7:66,040,638...66,077,265
JBrowse link
G Angptl4 angiopoietin-like 4 increases expression ISO 2,3-pentanedione results in increased expression of ANGPTL4 mRNA CTD PMID:25710175 NCBI chr17:33,993,874...34,000,549
Ensembl chr17:33,992,724...34,000,804
JBrowse link
G Apln apelin increases expression ISO 2,3-pentanedione results in increased expression of APLN mRNA CTD PMID:25710175 NCBI chr  X:47,114,023...47,123,730
Ensembl chr  X:47,114,023...47,123,730
JBrowse link
G Arhgap17 Rho GTPase activating protein 17 increases expression ISO 2,3-pentanedione results in increased expression of ARHGAP17 mRNA CTD PMID:25710175 NCBI chr 7:122,878,372...122,969,171
Ensembl chr 7:122,878,441...122,969,138
JBrowse link
G Bcat1 branched chain aminotransferase 1, cytosolic increases expression ISO 2,3-pentanedione results in increased expression of BCAT1 mRNA CTD PMID:25710175 NCBI chr 6:144,939,561...145,021,883
Ensembl chr 6:144,939,561...145,021,910
JBrowse link
G Bmp3 bone morphogenetic protein 3 decreases expression ISO 2,3-pentanedione results in decreased expression of BMP3 mRNA CTD PMID:25710175 NCBI chr 5:99,002,274...99,031,912
Ensembl chr 5:99,002,274...99,032,255
JBrowse link
G C9 complement component 9 decreases expression ISO 2,3-pentanedione results in decreased expression of C9 mRNA CTD PMID:25710175 NCBI chr15:6,474,827...6,528,306
Ensembl chr15:6,474,808...6,528,232
JBrowse link
G Cc2d2a coiled-coil and C2 domain containing 2A decreases expression ISO 2,3-pentanedione results in decreased expression of CC2D2A mRNA CTD PMID:30710127 NCBI chr 5:43,819,715...43,898,317
Ensembl chr 5:43,819,688...43,898,314
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression ISO 2,3-pentanedione results in increased expression of CCN2 mRNA CTD PMID:25710175 NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581
JBrowse link
G Ccn4 cellular communication network factor 4 increases expression ISO 2,3-pentanedione results in increased expression of CCN4 mRNA CTD PMID:25710175 NCBI chr15:66,763,337...66,795,050
Ensembl chr15:66,763,169...66,795,050
JBrowse link
G Cd36 CD36 molecule increases expression ISO 2,3-pentanedione results in increased expression of CD36 mRNA CTD PMID:25710175 NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799
JBrowse link
G Cdc20b cell division cycle 20B decreases expression ISO 2,3-pentanedione results in decreased expression of CDC20B mRNA CTD PMID:30710127 NCBI chr13:113,171,514...113,257,553
Ensembl chr13:113,171,645...113,227,729
JBrowse link
G Cdhr4 cadherin-related family member 4 decreases expression ISO 2,3-pentanedione results in decreased expression of CDHR4 mRNA CTD PMID:25710175 NCBI chr 9:107,869,656...107,876,880
Ensembl chr 9:107,869,696...107,876,883
JBrowse link
G Ces1d carboxylesterase 1D decreases expression ISO 2,3-pentanedione results in decreased expression of CES1D mRNA CTD PMID:25710175 NCBI chr 8:93,892,700...93,924,432
Ensembl chr 8:93,892,696...93,924,466
JBrowse link
G Cfap221 cilia and flagella associated protein 221 decreases expression ISO 2,3-pentanedione results in decreased expression of CFAP221 mRNA CTD PMID:30710127 NCBI chr 1:119,851,070...119,934,624
Ensembl chr 1:119,851,071...119,924,964
JBrowse link
G Cfap70 cilia and flagella associated protein 70 decreases expression ISO 2,3-pentanedione results in decreased expression of CFAP70 mRNA CTD PMID:30710127 NCBI chr14:20,444,258...20,502,332
Ensembl chr14:20,444,261...20,502,294
JBrowse link
G Cldn18 claudin 18 increases expression ISO 2,3-pentanedione results in increased expression of CLDN18 mRNA CTD PMID:25710175 NCBI chr 9:99,572,849...99,599,320
Ensembl chr 9:99,571,514...99,599,320
JBrowse link
G Clic5 chloride intracellular channel 5 increases expression ISO 2,3-pentanedione results in increased expression of CLIC5 mRNA CTD PMID:25710175 NCBI chr17:44,445,671...44,591,059
Ensembl chr17:44,445,659...44,591,059
JBrowse link
G Cma1 chymase 1, mast cell increases expression ISO 2,3-pentanedione results in increased expression of CMA1 mRNA CTD PMID:25710175 NCBI chr14:56,178,908...56,182,132
Ensembl chr14:56,178,908...56,182,132
JBrowse link
G Col12a1 collagen, type XII, alpha 1 increases expression ISO 2,3-pentanedione results in increased expression of COL12A1 mRNA CTD PMID:25710175 NCBI chr 9:79,506,269...79,628,423
Ensembl chr 9:79,506,273...79,626,113
JBrowse link
G Col13a1 collagen, type XIII, alpha 1 decreases expression ISO 2,3-pentanedione results in decreased expression of COL13A1 mRNA CTD PMID:25710175 NCBI chr10:61,674,013...61,814,985
Ensembl chr10:61,674,015...61,814,887
JBrowse link
G Col14a1 collagen, type XIV, alpha 1 increases expression ISO 2,3-pentanedione results in increased expression of COL14A1 mRNA CTD PMID:25710175 NCBI chr15:55,171,040...55,384,199
Ensembl chr15:55,171,146...55,384,199
JBrowse link
G Col18a1 collagen, type XVIII, alpha 1 increases expression ISO 2,3-pentanedione results in increased expression of COL18A1 mRNA CTD PMID:25710175 NCBI chr10:76,888,013...77,002,351
Ensembl chr10:76,888,012...77,002,382
JBrowse link
G Col1a2 collagen, type I, alpha 2 increases expression ISO 2,3-pentanedione results in increased expression of COL1A2 mRNA CTD PMID:25710175 NCBI chr 6:4,505,618...4,541,543
Ensembl chr 6:4,504,814...4,541,544
JBrowse link
G Col4a1 collagen, type IV, alpha 1 increases expression ISO 2,3-pentanedione results in increased expression of COL4A1 mRNA CTD PMID:25710175 NCBI chr 8:11,248,423...11,362,889
Ensembl chr 8:11,248,423...11,362,826
JBrowse link
G Col5a1 collagen, type V, alpha 1 increases expression ISO 2,3-pentanedione results in increased expression of COL5A1 mRNA CTD PMID:25710175 NCBI chr 2:27,776,393...27,929,522
Ensembl chr 2:27,776,437...27,929,526
JBrowse link
G Col5a2 collagen, type V, alpha 2 increases expression ISO 2,3-pentanedione results in increased expression of COL5A2 mRNA CTD PMID:25710175 NCBI chr 1:45,413,491...45,542,442
Ensembl chr 1:45,413,481...45,542,442
JBrowse link
G Col5a3 collagen, type V, alpha 3 increases expression ISO 2,3-pentanedione results in increased expression of COL5A3 mRNA CTD PMID:25710175 NCBI chr 9:20,681,353...20,726,363
Ensembl chr 9:20,681,346...20,726,363
JBrowse link
G Col6a2 collagen, type VI, alpha 2 increases expression ISO 2,3-pentanedione results in increased expression of COL6A2 mRNA CTD PMID:25710175 NCBI chr10:76,431,590...76,459,464
Ensembl chr10:76,431,596...76,459,464
JBrowse link
G Cpxm2 carboxypeptidase X, M14 family member 2 decreases expression ISO 2,3-pentanedione results in decreased expression of CPXM2 mRNA CTD PMID:30710127 NCBI chr 7:131,634,416...131,756,483
Ensembl chr 7:131,634,416...131,756,468
JBrowse link
G Crabp2 cellular retinoic acid binding protein II increases expression ISO 2,3-pentanedione results in increased expression of CRABP2 mRNA CTD PMID:25710175 NCBI chr 3:87,856,000...87,860,679
Ensembl chr 3:87,855,973...87,860,683
JBrowse link
G Csf3 colony stimulating factor 3 (granulocyte) decreases expression ISO 2,3-pentanedione results in decreased expression of CSF3 mRNA CTD PMID:30710127 NCBI chr11:98,591,287...98,594,457
Ensembl chr11:98,592,089...98,594,455
JBrowse link
G Cthrc1 collagen triple helix repeat containing 1 increases expression ISO 2,3-pentanedione results in increased expression of CTHRC1 mRNA CTD PMID:25710175 NCBI chr15:38,940,327...38,950,516
Ensembl chr15:38,940,327...38,950,516
JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 increases expression ISO 2,3-pentanedione results in increased expression of CX3CR1 mRNA CTD PMID:25710175 NCBI chr 9:119,877,749...119,897,362
Ensembl chr 9:119,877,749...119,898,945
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression ISO 2,3-pentanedione results in decreased expression of CXCL1 mRNA CTD PMID:25710175 NCBI chr 5:91,039,104...91,040,980
Ensembl chr 5:91,039,100...91,040,974
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression ISO 2,3-pentanedione results in decreased expression of CXCL3 mRNA CTD PMID:25710175 NCBI chr 5:90,933,960...90,935,952
Ensembl chr 5:90,933,962...90,937,459
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression
increases expression
ISO 2,3-pentanedione results in decreased expression of CXCR4 mRNA
2,3-pentanedione results in increased expression of CXCR4 mRNA
CTD PMID:25710175 NCBI chr 1:128,515,936...128,520,036
Ensembl chr 1:128,515,936...128,520,030
JBrowse link
G Cyp2a4 cytochrome P450, family 2, subfamily a, polypeptide 4 decreases expression ISO 2,3-pentanedione results in decreased expression of CYP2A3 mRNA CTD PMID:25710175 NCBI chr 7:26,006,617...26,014,513
Ensembl chr 7:26,006,594...26,014,513
JBrowse link
G Cyp2f2 cytochrome P450, family 2, subfamily f, polypeptide 2 decreases expression ISO 2,3-pentanedione results in decreased expression of CYP2F4 mRNA CTD PMID:25710175 NCBI chr 7:26,819,380...26,833,085
Ensembl chr 7:26,819,334...26,833,085
JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 decreases expression ISO 2,3-pentanedione results in decreased expression of CYP4B1 mRNA CTD PMID:25710175 NCBI chr 4:115,481,895...115,504,918
Ensembl chr 4:115,481,922...115,504,920
JBrowse link
G Dhrs9 dehydrogenase/reductase 9 increases expression ISO 2,3-pentanedione results in increased expression of DHRS9 mRNA CTD PMID:30710127 NCBI chr 2:69,210,806...69,233,430
Ensembl chr 2:69,210,789...69,234,877
JBrowse link
G Dmrt2 doublesex and mab-3 related transcription factor 2 decreases expression ISO 2,3-pentanedione results in decreased expression of DMRT2 mRNA CTD PMID:25710175 NCBI chr19:25,649,758...25,656,355
Ensembl chr19:25,649,775...25,656,355
JBrowse link
G Dnaaf1 dynein, axonemal assembly factor 1 decreases expression ISO 2,3-pentanedione results in decreased expression of DNAAF1 mRNA CTD PMID:30710127 NCBI chr 8:120,301,974...120,325,193
Ensembl chr 8:120,301,974...120,325,193
JBrowse link
G Dnah12 dynein, axonemal, heavy chain 12 decreases expression ISO 2,3-pentanedione results in decreased expression of DNAH12 mRNA CTD PMID:30710127 NCBI chr14:26,412,709...26,614,250
Ensembl chr14:26,414,429...26,613,660
JBrowse link
G Dnah3 dynein, axonemal, heavy chain 3 decreases expression ISO 2,3-pentanedione results in decreased expression of DNAH3 mRNA CTD PMID:30710127 NCBI chr 7:119,520,555...119,694,520
Ensembl chr 7:119,521,894...119,694,503
JBrowse link
G Dnah6 dynein, axonemal, heavy chain 6 decreases expression ISO 2,3-pentanedione results in decreased expression of DNAH6 mRNA CTD PMID:30710127 NCBI chr 6:72,994,586...73,199,327
Ensembl chr 6:72,994,589...73,198,634
JBrowse link
G Dnai1 dynein axonemal intermediate chain 1 decreases expression ISO 2,3-pentanedione results in decreased expression of DNAI1 mRNA CTD PMID:30710127 NCBI chr 4:41,569,731...41,638,158
Ensembl chr 4:41,569,775...41,638,158
JBrowse link
G Egfr epidermal growth factor receptor increases expression ISO 2,3-pentanedione results in increased expression of EGFR mRNA CTD PMID:25710175 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158
JBrowse link
G Egr2 early growth response 2 increases expression ISO 2,3-pentanedione results in increased expression of EGR2 mRNA CTD PMID:25710175 NCBI chr10:67,370,334...67,383,354
Ensembl chr10:67,371,305...67,378,018
JBrowse link
G Fbln1 fibulin 1 decreases expression ISO 2,3-pentanedione results in decreased expression of FBLN1 mRNA CTD PMID:25710175 NCBI chr15:85,090,150...85,170,495
Ensembl chr15:85,090,150...85,170,736
JBrowse link
G Fbn1 fibrillin 1 increases expression ISO 2,3-pentanedione results in increased expression of FBN1 mRNA CTD PMID:25710175 NCBI chr 2:125,142,514...125,348,417
Ensembl chr 2:125,142,514...125,349,913
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 decreases expression ISO 2,3-pentanedione results in decreased expression of FGFR2 mRNA CTD PMID:25710175 NCBI chr 7:129,764,181...129,868,538
Ensembl chr 7:129,764,181...132,725,079
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 decreases expression ISO 2,3-pentanedione results in decreased expression of FGFR3 mRNA CTD PMID:25710175 NCBI chr 5:33,879,068...33,894,412
Ensembl chr 5:33,879,018...33,894,412
JBrowse link
G Fmo2 flavin containing monooxygenase 2 decreases expression ISO 2,3-pentanedione results in decreased expression of FMO2 mRNA CTD PMID:25710175 NCBI chr 1:162,701,886...162,726,327
Ensembl chr 1:162,701,886...162,726,295
JBrowse link
G Fn1 fibronectin 1 increases expression ISO 2,3-pentanedione results in increased expression of FN1 mRNA CTD PMID:25710175 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359
JBrowse link
G Fndc3b fibronectin type III domain containing 3B decreases expression ISO 2,3-pentanedione results in decreased expression of FNDC3B mRNA CTD PMID:25710175 NCBI chr 3:27,470,284...27,765,469
Ensembl chr 3:27,470,311...27,765,456
JBrowse link
G Gad1 glutamate decarboxylase 1 decreases expression ISO 2,3-pentanedione results in decreased expression of GAD1 mRNA CTD PMID:25710175 NCBI chr 2:70,392,109...70,432,358
Ensembl chr 2:70,383,416...70,432,358
JBrowse link
G Gas6 growth arrest specific 6 increases expression ISO 2,3-pentanedione results in increased expression of GAS6 mRNA CTD PMID:25710175 NCBI chr 8:13,515,374...13,544,535
Ensembl chr 8:13,515,374...13,544,490
JBrowse link
G Ghitm growth hormone inducible transmembrane protein decreases expression ISO 2,3-pentanedione results in decreased expression of GHITM mRNA CTD PMID:25710175 NCBI chr14:36,842,401...36,857,279
Ensembl chr14:36,842,049...36,857,229
JBrowse link
G Gpr155 G protein-coupled receptor 155 decreases expression ISO 2,3-pentanedione results in decreased expression of GPR155 mRNA CTD PMID:25710175 NCBI chr 2:73,171,850...73,216,842
Ensembl chr 2:73,171,850...73,216,916
JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression ISO 2,3-pentanedione results in increased expression of GPX2 mRNA CTD PMID:30710127 NCBI chr12:76,839,109...76,842,328
Ensembl chr12:76,839,107...76,842,273
JBrowse link
G Grb10 growth factor receptor bound protein 10 increases expression ISO 2,3-pentanedione results in increased expression of GRB10 mRNA CTD PMID:25710175 NCBI chr11:11,880,499...11,987,428
Ensembl chr11:11,880,508...11,988,683
JBrowse link
G Gsta1 glutathione S-transferase, alpha 1 (Ya) decreases expression ISO 2,3-pentanedione results in decreased expression of GSTA5 mRNA CTD PMID:25710175 NCBI chr 9:78,137,951...78,149,965
Ensembl chr 9:78,137,938...78,149,966
JBrowse link
G Hap1 huntingtin-associated protein 1 decreases expression ISO 2,3-pentanedione results in decreased expression of HAP1 mRNA CTD PMID:25710175 NCBI chr11:100,238,153...100,247,808
Ensembl chr11:100,238,153...100,246,954
JBrowse link
G Has2 hyaluronan synthase 2 increases expression ISO 2,3-pentanedione results in increased expression of HAS2 mRNA CTD PMID:25710175 NCBI chr15:56,529,023...56,557,942
Ensembl chr15:56,529,023...56,557,935
JBrowse link
G Hbegf heparin-binding EGF-like growth factor increases expression ISO 2,3-pentanedione results in increased expression of HBEGF mRNA CTD PMID:25710175 NCBI chr18:36,637,980...36,648,858
Ensembl chr18:36,637,980...36,648,858
JBrowse link
G Hdac10 histone deacetylase 10 increases expression ISO 2,3-pentanedione results in increased expression of HDAC10 mRNA CTD PMID:25710175 NCBI chr15:89,007,506...89,012,903
Ensembl chr15:89,007,510...89,012,903
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO 2,3-pentanedione results in increased expression of IGF1 mRNA CTD PMID:25710175 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904
JBrowse link
G Igf2bp2 insulin-like growth factor 2 mRNA binding protein 2 increases expression ISO 2,3-pentanedione results in increased expression of IGF2BP2 mRNA CTD PMID:25710175 NCBI chr16:21,877,759...21,982,049
Ensembl chr16:21,877,759...21,982,049
JBrowse link
G Igfbp4 insulin-like growth factor binding protein 4 increases expression ISO 2,3-pentanedione results in increased expression of IGFBP4 mRNA CTD PMID:25710175 NCBI chr11:98,930,820...98,943,481
Ensembl chr11:98,932,070...98,945,218
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 decreases expression ISO 2,3-pentanedione results in decreased expression of IGFBP5 mRNA CTD PMID:25710175 NCBI chr 1:72,897,224...72,914,024
Ensembl chr 1:72,897,091...72,914,043
JBrowse link
G Il18 interleukin 18 increases expression ISO 2,3-pentanedione results in increased expression of IL18 mRNA CTD PMID:25710175 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO 2,3-pentanedione results in increased expression of IL1A mRNA CTD PMID:25710175 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
JBrowse link
G Il1rn interleukin 1 receptor antagonist increases expression ISO 2,3-pentanedione results in increased expression of IL1RN mRNA CTD PMID:25710175 NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506
JBrowse link
G Il24 interleukin 24 increases expression ISO 2,3-pentanedione results in increased expression of IL24 mRNA CTD PMID:25710175 NCBI chr 1:130,809,801...130,815,153
Ensembl chr 1:130,809,811...130,815,191
JBrowse link
G Il33 interleukin 33 increases expression
decreases expression
ISO 2,3-pentanedione results in increased expression of IL33 mRNA
2,3-pentanedione results in decreased expression of IL33 mRNA
CTD PMID:25710175 PMID:30710127 NCBI chr19:29,902,513...29,938,118
Ensembl chr19:29,902,514...29,938,118
JBrowse link
G Inhba inhibin beta-A increases expression ISO 2,3-pentanedione results in increased expression of INHBA mRNA CTD PMID:25710175 NCBI chr13:16,178,841...16,206,194
Ensembl chr13:16,186,436...16,206,206
JBrowse link
G Irak1bp1 interleukin-1 receptor-associated kinase 1 binding protein 1 decreases expression ISO 2,3-pentanedione results in decreased expression of IRAK1BP1 mRNA CTD PMID:25710175 NCBI chr 9:82,711,859...82,729,741
Ensembl chr 9:82,711,593...82,729,740
JBrowse link
G Itga5 integrin alpha 5 (fibronectin receptor alpha) increases expression ISO 2,3-pentanedione results in increased expression of ITGA5 mRNA CTD PMID:25710175 NCBI chr15:103,252,713...103,275,218
Ensembl chr15:103,252,713...103,275,190
JBrowse link
G Itga6 integrin alpha 6 increases expression ISO 2,3-pentanedione results in increased expression of ITGA6 mRNA CTD PMID:25710175 NCBI chr 2:71,617,236...71,688,761
Ensembl chr 2:71,575,960...71,688,760
JBrowse link
G Itgb1 integrin beta 1 (fibronectin receptor beta) increases expression ISO 2,3-pentanedione results in increased expression of ITGB1 mRNA CTD PMID:25710175 NCBI chr 8:129,412,135...129,460,060
Ensembl chr 8:129,412,135...129,459,681
JBrowse link
G Itgb3 integrin beta 3 increases expression ISO 2,3-pentanedione results in increased expression of ITGB3 mRNA CTD PMID:25710175 NCBI chr11:104,498,826...104,561,302
Ensembl chr11:104,498,826...104,561,302
JBrowse link
G Klhl38 kelch-like 38 decreases expression ISO 2,3-pentanedione results in decreased expression of KLHL38 mRNA CTD PMID:25710175 NCBI chr15:58,176,076...58,187,623
Ensembl chr15:58,177,969...58,187,565
JBrowse link
G Krt13 keratin 13 increases expression ISO 2,3-pentanedione results in increased expression of KRT13 mRNA CTD PMID:30710127 NCBI chr11:100,008,153...100,012,392
Ensembl chr11:100,008,153...100,012,392
JBrowse link
G Krt14 keratin 14 increases expression ISO 2,3-pentanedione results in increased expression of KRT14 mRNA CTD PMID:30710127 NCBI chr11:100,093,988...100,098,336
Ensembl chr11:100,093,988...100,098,374
JBrowse link
G Krt16 keratin 16 increases expression ISO 2,3-pentanedione results in increased expression of KRT16 mRNA CTD PMID:30710127 NCBI chr11:100,136,917...100,139,728
Ensembl chr11:100,136,917...100,139,728
JBrowse link
G Krt4 keratin 4 increases expression ISO 2,3-pentanedione results in increased expression of KRT4 mRNA CTD PMID:30710127 NCBI chr15:101,826,970...101,833,170
Ensembl chr15:101,826,970...101,833,170
JBrowse link
G Lamb3 laminin, beta 3 increases expression ISO 2,3-pentanedione results in increased expression of LAMB3 mRNA CTD PMID:25710175 NCBI chr 1:192,976,661...193,026,186
Ensembl chr 1:192,890,007...193,026,186
JBrowse link
G Lamc2 laminin, gamma 2 increases expression ISO 2,3-pentanedione results in increased expression of LAMC2 mRNA CTD PMID:25710175 NCBI chr 1:152,998,502...153,062,193
Ensembl chr 1:152,998,502...153,062,193
JBrowse link
G Lamc3 laminin gamma 3 decreases expression ISO 2,3-pentanedione results in decreased expression of LAMC3 mRNA CTD PMID:25710175 NCBI chr 2:31,777,293...31,839,095
Ensembl chr 2:31,777,303...31,836,551
JBrowse link
G Lgi1 leucine-rich repeat LGI family, member 1 decreases expression ISO 2,3-pentanedione results in decreased expression of LGI1 mRNA CTD PMID:25710175 NCBI chr19:38,253,135...38,297,387
Ensembl chr19:38,252,984...38,300,662
JBrowse link
G Lox lysyl oxidase increases expression ISO 2,3-pentanedione results in increased expression of LOX mRNA CTD PMID:25710175 NCBI chr18:52,649,132...52,662,939
Ensembl chr18:52,649,139...52,662,939
JBrowse link
G Loxl2 lysyl oxidase-like 2 increases expression ISO 2,3-pentanedione results in increased expression of LOXL2 mRNA CTD PMID:25710175 NCBI chr14:69,846,085...69,933,283
Ensembl chr14:69,846,517...69,933,283
JBrowse link
G Lrp10 low-density lipoprotein receptor-related protein 10 increases expression ISO 2,3-pentanedione results in increased expression of LRP10 mRNA CTD PMID:25710175 NCBI chr14:54,701,260...54,707,749
Ensembl chr14:54,701,594...54,708,954
JBrowse link
G Mir205hg Mir205 host gene decreases expression ISO 2,3-pentanedione results in decreased expression of MIR205HG mRNA CTD PMID:30710127 NCBI chr 1:193,188,768...193,192,518
Ensembl chr 1:193,189,546...193,192,482
JBrowse link
G Mmp14 matrix metallopeptidase 14 (membrane-inserted) increases expression ISO 2,3-pentanedione results in increased expression of MMP14 mRNA CTD PMID:25710175 NCBI chr14:54,669,055...54,679,913
Ensembl chr14:54,669,069...54,682,821
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression ISO 2,3-pentanedione results in increased expression of MMP2 mRNA CTD PMID:25710175 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
JBrowse link
G Mmp24 matrix metallopeptidase 24 decreases expression ISO 2,3-pentanedione results in decreased expression of MMP24 mRNA CTD PMID:25710175 NCBI chr 2:155,617,262...155,660,286
Ensembl chr 2:155,617,262...155,660,286
JBrowse link
G Ngf nerve growth factor increases expression ISO 2,3-pentanedione results in increased expression of NGF mRNA CTD PMID:25710175 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329
JBrowse link
G Nkain1 Na+/K+ transporting ATPase interacting 1 increases expression ISO 2,3-pentanedione results in increased expression of NKAIN1 mRNA CTD PMID:25710175 NCBI chr 4:130,297,176...130,341,115
Ensembl chr 4:130,297,197...130,339,644
JBrowse link
G Nog noggin increases expression ISO 2,3-pentanedione results in increased expression of NOG mRNA CTD PMID:25710175 NCBI chr11:89,191,464...89,193,385
Ensembl chr11:89,191,464...89,193,158
JBrowse link
G Nrg1 neuregulin 1 increases expression ISO 2,3-pentanedione results in increased expression of NRG1 mRNA CTD PMID:25710175 NCBI chr 8:32,299,493...33,381,858
Ensembl chr 8:32,304,579...33,374,825
Ensembl chr 8:32,304,579...33,374,825
JBrowse link
G Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 decreases expression ISO 2,3-pentanedione results in decreased expression of PAPSS2 mRNA CTD PMID:30710127 NCBI chr19:32,573,072...32,644,587
Ensembl chr19:32,573,190...32,644,587
JBrowse link
G Pdgfrb platelet derived growth factor receptor, beta polypeptide increases expression ISO 2,3-pentanedione results in increased expression of PDGFRB mRNA CTD PMID:25710175 NCBI chr18:61,178,194...61,218,139
Ensembl chr18:61,178,222...61,218,133
JBrowse link
G Plat plasminogen activator, tissue increases expression ISO 2,3-pentanedione results in increased expression of PLAT mRNA CTD PMID:25710175 NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860
JBrowse link
G Plau plasminogen activator, urokinase increases expression ISO 2,3-pentanedione results in increased expression of PLAU mRNA CTD PMID:25710175 NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453
JBrowse link
G Plaur plasminogen activator, urokinase receptor increases expression ISO 2,3-pentanedione results in increased expression of PLAUR mRNA CTD PMID:25710175 NCBI chr 7:24,161,857...24,175,393
Ensembl chr 7:24,161,909...24,175,393
JBrowse link
G Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 increases expression ISO 2,3-pentanedione results in increased expression of PLOD2 mRNA CTD PMID:25710175 NCBI chr 9:92,421,828...92,490,481
Ensembl chr 9:92,424,276...92,490,481
JBrowse link
G Pon1 paraoxonase 1 decreases expression ISO 2,3-pentanedione results in decreased expression of PON1 mRNA CTD PMID:25710175 NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO 2,3-pentanedione results in decreased expression of PPARA mRNA CTD PMID:25710175 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
JBrowse link
G Prom1 prominin 1 decreases expression ISO 2,3-pentanedione results in decreased expression of PROM1 mRNA CTD PMID:30710127 NCBI chr 5:44,150,963...44,260,850
Ensembl chr 5:44,150,962...44,259,374
JBrowse link
G Prss22 serine protease 22 increases expression ISO 2,3-pentanedione results in increased expression of PRSS22 mRNA CTD PMID:25710175 NCBI chr17:24,212,508...24,219,696
Ensembl chr17:24,212,508...24,217,074
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO 2,3-pentanedione results in decreased expression of PTGS2 mRNA CTD PMID:30710127 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Pthlh parathyroid hormone-like peptide decreases expression ISO 2,3-pentanedione results in decreased expression of PTHLH mRNA CTD PMID:30710127 NCBI chr 6:147,153,607...147,165,511
Ensembl chr 6:147,153,599...147,165,681
JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 decreases expression ISO 2,3-pentanedione results in decreased expression of RASGRP1 mRNA CTD PMID:25710175 NCBI chr 2:117,110,464...117,173,358
Ensembl chr 2:117,110,474...117,173,482
JBrowse link
G S100a1 S100 calcium binding protein A1 decreases expression ISO 2,3-pentanedione results in decreased expression of S100A1 mRNA CTD PMID:25710175 NCBI chr 3:90,418,341...90,421,637
Ensembl chr 3:90,418,341...90,421,699
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 decreases expression ISO 2,3-pentanedione results in decreased expression of S1PR1 mRNA CTD PMID:25710175 NCBI chr 3:115,504,082...115,508,704
Ensembl chr 3:115,504,082...115,508,721
JBrowse link
G Sbp spermine binding protein decreases expression ISO 2,3-pentanedione results in decreased expression of SBP mRNA CTD PMID:25710175 NCBI chr17:24,141,525...24,164,577
Ensembl chr17:24,160,646...24,164,581
JBrowse link
G Scgb1a1 secretoglobin, family 1A, member 1 increases expression ISO 2,3-pentanedione results in increased expression of SCGB1A1 mRNA CTD PMID:30710127 NCBI chr19:9,061,006...9,065,320
Ensembl chr19:9,061,000...9,065,322
JBrowse link
G Sec14l3 SEC14-like lipid binding 3 decreases expression ISO 2,3-pentanedione results in decreased expression of SEC14L3 mRNA CTD PMID:25710175 NCBI chr11:4,014,853...4,028,990
Ensembl chr11:4,014,841...4,027,736
JBrowse link
G Serpinb5 serine (or cysteine) peptidase inhibitor, clade B, member 5 decreases expression ISO 2,3-pentanedione results in decreased expression of SERPINB5 mRNA CTD PMID:25710175 NCBI chr 1:106,788,905...106,811,078
Ensembl chr 1:106,788,903...106,811,078
JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 increases expression ISO 2,3-pentanedione results in increased expression of SERPINE1 mRNA CTD PMID:25710175 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122
JBrowse link
G Serpinf1 serine (or cysteine) peptidase inhibitor, clade F, member 1 increases expression ISO 2,3-pentanedione results in increased expression of SERPINF1 mRNA CTD PMID:25710175 NCBI chr11:75,300,855...75,313,449
Ensembl chr11:75,300,595...75,313,527
JBrowse link
G Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1 increases expression ISO 2,3-pentanedione results in increased expression of SERPING1 mRNA CTD PMID:25710175 NCBI chr 2:84,595,704...84,605,748
Ensembl chr 2:84,595,731...84,605,788
JBrowse link
G Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 increases expression ISO 2,3-pentanedione results in increased expression of SERPINH1 mRNA CTD PMID:25710175 NCBI chr 7:98,994,583...99,002,321
Ensembl chr 7:98,994,583...99,002,446
JBrowse link
G Slc15a1 solute carrier family 15 (oligopeptide transporter), member 1 increases expression ISO 2,3-pentanedione results in increased expression of SLC15A1 mRNA CTD PMID:25710175 NCBI chr14:121,697,033...121,742,666
Ensembl chr14:121,697,033...121,742,664
JBrowse link
G Slc15a2 solute carrier family 15 (H+/peptide transporter), member 2 decreases expression ISO 2,3-pentanedione results in decreased expression of SLC15A2 mRNA CTD PMID:25710175 NCBI chr16:36,570,523...36,605,506
Ensembl chr16:36,570,539...36,605,324
JBrowse link
G Slc23a1 solute carrier family 23 (nucleobase transporters), member 1 decreases expression ISO 2,3-pentanedione results in decreased expression of SLC23A1 mRNA CTD PMID:25710175 NCBI chr18:35,747,657...35,762,900
Ensembl chr18:35,747,657...35,760,297
JBrowse link
G Sorcs2 sortilin-related VPS10 domain containing receptor 2 decreases expression ISO 2,3-pentanedione results in decreased expression of SORCS2 mRNA CTD PMID:30710127 NCBI chr 5:36,174,524...36,555,541
Ensembl chr 5:36,174,524...36,555,483
JBrowse link
G Sorl1 sortilin-related receptor, LDLR class A repeats-containing decreases expression ISO 2,3-pentanedione results in decreased expression of SORL1 mRNA CTD PMID:25710175 NCBI chr 9:41,876,005...42,035,593
Ensembl chr 9:41,876,016...42,035,593
JBrowse link
G Spag17 sperm associated antigen 17 decreases expression ISO 2,3-pentanedione results in decreased expression of SPAG17 mRNA CTD PMID:30710127 NCBI chr 3:99,792,653...100,050,638
Ensembl chr 3:99,792,722...100,050,638
JBrowse link
G Spon1 spondin 1, (f-spondin) extracellular matrix protein increases expression ISO 2,3-pentanedione results in increased expression of SPON1 mRNA CTD PMID:25710175 NCBI chr 7:113,365,235...113,642,610
Ensembl chr 7:113,365,235...113,642,605
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO 2,3-pentanedione results in increased expression of SPP1 mRNA CTD PMID:25710175 NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916
JBrowse link
G Spr sepiapterin reductase decreases expression ISO 2,3-pentanedione results in decreased expression of SPR mRNA CTD PMID:25710175 NCBI chr 6:85,110,662...85,114,746
Ensembl chr 6:85,107,158...85,114,748
JBrowse link
G Stra6 stimulated by retinoic acid gene 6 decreases expression ISO 2,3-pentanedione results in decreased expression of STRA6 mRNA CTD PMID:25710175 NCBI chr 9:57,971,076...58,061,287
Ensembl chr 9:57,971,071...58,061,279
JBrowse link
G Tekt1 tektin 1 decreases expression ISO 2,3-pentanedione results in decreased expression of TEKT1 mRNA CTD PMID:30710127 NCBI chr11:72,235,543...72,253,268
Ensembl chr11:72,235,548...72,253,268
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression ISO 2,3-pentanedione results in increased expression of TGFB2 mRNA CTD PMID:25710175 NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186
JBrowse link
G Tgfbi transforming growth factor, beta induced increases expression ISO 2,3-pentanedione results in increased expression of TGFBI mRNA CTD PMID:25710175 NCBI chr13:56,757,399...56,787,172
Ensembl chr13:56,757,336...56,787,375
JBrowse link
G Tgm1 transglutaminase 1, K polypeptide increases expression ISO 2,3-pentanedione results in increased expression of TGM1 mRNA CTD PMID:25710175 NCBI chr14:55,937,466...55,951,378
Ensembl chr14:55,937,466...55,951,383
JBrowse link
G Thbs2 thrombospondin 2 increases expression ISO 2,3-pentanedione results in increased expression of THBS2 mRNA CTD PMID:25710175 NCBI chr17:14,885,762...14,914,524
Ensembl chr17:14,885,762...14,914,497
JBrowse link
G Thbs4 thrombospondin 4 decreases expression ISO 2,3-pentanedione results in decreased expression of THBS4 mRNA CTD PMID:25710175 NCBI chr13:92,888,094...92,931,326
Ensembl chr13:92,888,098...92,931,326
JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 increases expression ISO 2,3-pentanedione results in increased expression of TIMP1 mRNA CTD PMID:25710175 NCBI chr  X:20,736,524...20,740,972
Ensembl chr  X:20,736,405...20,740,974
JBrowse link
G Timp2 tissue inhibitor of metalloproteinase 2 increases expression ISO 2,3-pentanedione results in increased expression of TIMP2 mRNA CTD PMID:25710175 NCBI chr11:118,191,887...118,246,237
Ensembl chr11:118,191,887...118,246,566
JBrowse link
G Timp4 tissue inhibitor of metalloproteinase 4 decreases expression ISO 2,3-pentanedione results in decreased expression of TIMP4 mRNA CTD PMID:25710175 NCBI chr 6:115,221,405...115,229,166
Ensembl chr 6:115,218,853...115,229,166
JBrowse link
G Tlr2 toll-like receptor 2 decreases expression ISO 2,3-pentanedione results in decreased expression of TLR2 mRNA CTD PMID:25710175 NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074
JBrowse link
G Tmem178 transmembrane protein 178 increases expression ISO 2,3-pentanedione results in increased expression of TMEM178 mRNA CTD PMID:25710175 NCBI chr17:81,252,061...81,309,245
Ensembl chr17:81,252,061...81,309,245
JBrowse link
G Tnc tenascin C increases expression ISO 2,3-pentanedione results in increased expression of TNC mRNA CTD PMID:25710175 NCBI chr 4:63,878,022...63,965,554
Ensembl chr 4:63,878,022...63,965,252
JBrowse link
G Tnfaip6 tumor necrosis factor alpha induced protein 6 increases expression ISO 2,3-pentanedione results in increased expression of TNFAIP6 mRNA CTD PMID:25710175 NCBI chr 2:51,928,125...51,946,693
Ensembl chr 2:51,928,021...51,946,698
JBrowse link
G Tnfrsf12a tumor necrosis factor receptor superfamily, member 12a increases expression ISO 2,3-pentanedione results in increased expression of TNFRSF12A mRNA CTD PMID:25710175 NCBI chr17:23,894,419...23,896,423
Ensembl chr17:23,894,419...23,896,442
JBrowse link
G Tnn tenascin N increases expression ISO 2,3-pentanedione results in increased expression of TNN mRNA CTD PMID:25710175 NCBI chr 1:159,912,599...159,981,242
Ensembl chr 1:159,912,599...159,981,150
JBrowse link
G Ubr2 ubiquitin protein ligase E3 component n-recognin 2 increases expression ISO 2,3-pentanedione results in increased expression of UBR2 mRNA CTD PMID:25710175 NCBI chr17:47,239,217...47,321,812
Ensembl chr17:47,239,221...47,321,482
JBrowse link
G Zfp318 zinc finger protein 318 increases expression ISO 2,3-pentanedione results in increased expression of ZFP318 mRNA CTD PMID:25710175 NCBI chr17:46,694,444...46,731,846
Ensembl chr17:46,694,657...46,731,846
JBrowse link
G Zfp853 zinc finger protein 853 decreases expression ISO 2,3-pentanedione results in decreased expression of ZFP853 mRNA CTD PMID:25710175 NCBI chr 5:143,269,283...143,279,757
Ensembl chr 5:143,272,793...143,279,378
JBrowse link
phenacyl bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2, mitochondrial multiple interactions ISO phenacyl bromide inhibits the reaction [4-dimethylaminocinnamaldehyde binds to ALDH2 protein] CTD PMID:10609638 NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887
JBrowse link
raspberry ketone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-Coenzyme A carboxylase alpha decreases expression EXP raspberry ketone results in decreased expression of ACACA mRNA CTD PMID:36460224 NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477
JBrowse link
G Apln apelin increases expression
multiple interactions
EXP raspberry ketone results in increased expression of APLN mRNA
raspberry ketone inhibits the reaction [Dietary Fats results in increased expression of APLN mRNA]
CTD PMID:36460224 NCBI chr  X:47,114,023...47,123,730
Ensembl chr  X:47,114,023...47,123,730
JBrowse link
G Ar androgen receptor multiple interactions ISO raspberry ketone binds to and results in decreased activity of AR protein CTD PMID:20226658 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821
JBrowse link
G Cpt1c carnitine palmitoyltransferase 1c increases expression EXP raspberry ketone results in increased expression of CPT1C mRNA CTD PMID:36460224 NCBI chr 7:44,607,907...44,624,304
Ensembl chr 7:44,608,796...44,624,275
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
EXP
ISO
raspberry ketone results in increased expression of DDIT3 mRNA
Acetylcysteine inhibits the reaction [raspberry ketone results in increased expression of DDIT3 mRNA]
CTD PMID:26867644 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha increases expression
multiple interactions
ISO
EXP
raspberry ketone results in increased expression of GADD45A mRNA
Acetylcysteine inhibits the reaction [raspberry ketone results in increased expression of GADD45A mRNA]
CTD PMID:26867644 NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions ISO [raspberry ketone co-treated with Resveratrol] inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; raspberry ketone inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein] CTD PMID:37009719 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
decreases expression
EXP Acetylcysteine inhibits the reaction [raspberry ketone results in decreased expression of GPX1 protein] CTD PMID:26867644 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542
JBrowse link
G Hmox1 heme oxygenase 1 affects expression EXP raspberry ketone affects the expression of HMOX1 mRNA CTD PMID:36460224 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Resveratrol co-treated with raspberry ketone] inhibits the reaction [Carbon Tetrachloride results in decreased expression of IL10 mRNA]; raspberry ketone inhibits the reaction [Carbon Tetrachloride results in decreased expression of IL10 mRNA] CTD PMID:37009719 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Resveratrol co-treated with raspberry ketone] inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B mRNA]; raspberry ketone inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B mRNA] CTD PMID:37009719 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
EXP
ISO
raspberry ketone results in increased expression of IL6 mRNA
[Resveratrol co-treated with raspberry ketone] inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; raspberry ketone inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]
CTD PMID:36460224 PMID:37009719 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Kcnc3 potassium voltage gated channel, Shaw-related subfamily, member 3 increases expression
multiple interactions
EXP raspberry ketone results in increased expression of KCNC3 mRNA
raspberry ketone inhibits the reaction [Dietary Fats results in increased expression of KCNC3 mRNA]
CTD PMID:36460224 NCBI chr 7:44,236,405...44,254,175
Ensembl chr 7:44,240,088...44,254,178
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [raspberry ketone co-treated with Resveratrol] inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP9 protein]; [Resveratrol co-treated with raspberry ketone] inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP9 mRNA]; raspberry ketone inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP9 mRNA]; raspberry ketone inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP9 protein] CTD PMID:37009719 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 affects expression EXP raspberry ketone affects the expression of NFE2L2 mRNA CTD PMID:36460224 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 affects expression EXP raspberry ketone affects the expression of NQO1 mRNA CTD PMID:36460224 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Or5d18 olfactory receptor family 5 subfamily D member 18 multiple interactions EXP raspberry ketone binds to and results in increased activity of OR5D18 protein CTD PMID:21142015 NCBI chr 2:87,864,540...87,865,481
Ensembl chr 2:87,862,632...87,868,043
JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 increases expression EXP raspberry ketone results in increased expression of PNPLA2 mRNA CTD PMID:36460224 NCBI chr 7:141,035,101...141,040,656
Ensembl chr 7:141,035,111...141,040,656
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression EXP raspberry ketone results in increased expression of PPARA mRNA CTD PMID:36460224 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma increases expression EXP raspberry ketone results in increased expression of PPARG mRNA CTD PMID:36460224 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [Resveratrol co-treated with raspberry ketone] inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; raspberry ketone inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA] CTD PMID:37009719 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 multiple interactions ISO [raspberry ketone co-treated with Resveratrol] inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein]; raspberry ketone inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein] CTD PMID:37009719 NCBI chr  X:20,736,524...20,740,972
Ensembl chr  X:20,736,405...20,740,974
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
EXP
ISO
raspberry ketone results in increased expression of TNF mRNA
[Resveratrol co-treated with raspberry ketone] inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; raspberry ketone inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]
CTD PMID:36460224 PMID:37009719 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
rottlerin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 c-abl oncogene 1, non-receptor tyrosine kinase multiple interactions ISO rottlerin inhibits the reaction [[ABL1 protein results in increased phosphorylation of and results in decreased activity of PPARG protein] which results in increased expression of COL1A1 protein] CTD PMID:17030193 NCBI chr 2:31,578,256...31,697,105
Ensembl chr 2:31,578,388...31,694,239
JBrowse link
G Acat1 acetyl-Coenzyme A acetyltransferase 1 multiple interactions ISO rottlerin inhibits the reaction [Serotonin results in increased expression of ACAT1 protein] CTD PMID:16157345 NCBI chr 9:53,491,822...53,521,650
Ensembl chr 9:53,491,822...53,521,682
JBrowse link
G Agt angiotensinogen multiple interactions ISO rottlerin inhibits the reaction [AGT protein affects the localization of ELAVL1 protein] CTD PMID:19246637 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445
JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions EXP rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of AIF1 protein] CTD PMID:30366073 NCBI chr17:35,389,967...35,394,977
Ensembl chr17:35,389,967...35,395,044
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 decreases phosphorylation
multiple interactions
EXP
ISO
rottlerin results in decreased phosphorylation of AKT1 protein
rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]
CTD PMID:15177934 PMID:19393235 PMID:22902833 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO rottlerin inhibits the reaction [PRKCD protein promotes the reaction [Lead results in increased localization of APP protein]] CTD PMID:20488202 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
JBrowse link
G Atg7 autophagy related 7 multiple interactions
increases expression
ISO 3-methyladenine inhibits the reaction [rottlerin results in increased expression of ATG7 protein] CTD PMID:22902833 NCBI chr 6:114,620,075...114,837,565
Ensembl chr 6:114,620,058...114,837,575
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in decreased expression of BAD protein modified form]]; rottlerin inhibits the reaction [trimethyltin results in decreased expression of BAD protein modified form] CTD PMID:25895139 NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO rottlerin inhibits the reaction [Doxorubicin results in increased activity of BAK1 protein] CTD PMID:15917298 NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983
JBrowse link
G Bax BCL2-associated X protein multiple interactions
increases expression
EXP
ISO
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in increased expression of BAX protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of BAX protein]; rottlerin inhibits the reaction [Cisplatin affects the localization of BAX protein]; rottlerin inhibits the reaction [trimethyltin results in increased expression of BAX protein]
rottlerin results in increased expression of BAX protein
CTD PMID:21633170 PMID:22902833 PMID:25895139 PMID:30366073 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression
multiple interactions
ISO
EXP
rottlerin results in decreased expression of BCL2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2 protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in decreased expression of BCL2 protein]; rottlerin inhibits the reaction [Cocaine results in decreased expression of BCL2 protein]; rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2 protein]; rottlerin promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]
CTD PMID:22902833 PMID:25895139 PMID:30366073 PMID:30393195 PMID:35995259 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression
multiple interactions
ISO
EXP
rottlerin results in decreased expression of BCL2L1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2L1 protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in decreased expression of BCL2L1 protein]; rottlerin inhibits the reaction [Cocaine results in decreased expression of BCL2L1 protein]; rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2L1 protein]
CTD PMID:22902833 PMID:25895139 PMID:30366073 PMID:30393195 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648
JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions
increases expression
ISO 3-methyladenine inhibits the reaction [rottlerin results in increased expression of BECN1 protein] CTD PMID:22902833 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BIRC3 mRNA] CTD PMID:14527959 NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187
JBrowse link
G Casp3 caspase 3 decreases activity
multiple interactions
increases activity
increases cleavage
ISO
EXP
rottlerin results in decreased activity of CASP3 protein
rottlerin inhibits the reaction [2-methylcyclopentadienyl manganese tricarbonyl results in increased activity of CASP3 protein]; rottlerin inhibits the reaction [Dieldrin results in increased activity of CASP3 protein]; rottlerin inhibits the reaction [naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP3 protein]]
rottlerin results in increased activity of CASP3 protein
rottlerin inhibits the reaction [NSC606985 results in increased activity of CASP3 protein]; rottlerin inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP3 protein]
rottlerin results in increased cleavage of CASP3 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in increased expression of CASP3 protein modified form]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased cleavage of CASP3 protein]; rottlerin inhibits the reaction [Cocaine results in increased cleavage of CASP3 protein]; rottlerin inhibits the reaction [trimethyltin results in increased expression of CASP3 protein modified form]
CTD PMID:11880503 PMID:12831855 PMID:19662097 PMID:21362627 PMID:22410117 More... NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp6 caspase 6 multiple interactions ISO rottlerin inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP6 protein] CTD PMID:21362627 NCBI chr 3:129,695,064...129,707,761
Ensembl chr 3:129,695,074...129,707,752
JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
EXP
ISO
rottlerin inhibits the reaction [Asbestos, Crocidolite results in increased cleavage of CASP9 protein]; rottlerin inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased cleavage of CASP9 protein]
rottlerin results in increased cleavage of CASP9 protein
CTD PMID:12626342 PMID:22902833 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [sorafenib co-treated with rottlerin] results in decreased expression of CCND1 protein CTD PMID:16959960 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Ccnd3 cyclin D3 multiple interactions ISO [sorafenib co-treated with rottlerin] results in decreased expression of CCND3 protein CTD PMID:16959960 NCBI chr17:47,815,976...47,910,614
Ensembl chr17:47,815,976...47,910,616
JBrowse link
G Cd38 CD38 antigen multiple interactions ISO rottlerin inhibits the reaction [Tretinoin results in increased expression of CD38 mRNA]; rottlerin inhibits the reaction [Tretinoin results in increased expression of CD38 protein] CTD PMID:21393419 NCBI chr 5:44,026,153...44,069,714
Ensembl chr 5:44,025,895...44,069,717
JBrowse link
G Cdh1 cadherin 1 multiple interactions
increases expression
EXP Paclitaxel promotes the reaction [rottlerin results in increased expression of CDH1 protein] CTD PMID:35995259 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878
JBrowse link
G Cdk4 cyclin dependent kinase 4 multiple interactions ISO [sorafenib co-treated with rottlerin] results in decreased expression of CDK4 protein CTD PMID:16959960 NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789
JBrowse link
G Cdk6 cyclin dependent kinase 6 multiple interactions ISO [sorafenib co-treated with rottlerin] results in decreased expression of CDK6 protein CTD PMID:16959960 NCBI chr 5:3,391,004...3,581,008
Ensembl chr 5:3,391,485...3,581,008
JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A multiple interactions ISO rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CDKN1A protein] CTD PMID:15976015 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO rottlerin inhibits the reaction [NSC606985 results in decreased expression of CEBPA protein]; rottlerin inhibits the reaction [NSC606985 results in increased ubiquitination of CEBPA protein] CTD PMID:19662097 NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353
JBrowse link
G Cldn1 claudin 1 affects localization ISO rottlerin affects the localization of CLDN1 protein CTD PMID:19297429 NCBI chr16:26,175,395...26,190,589
Ensembl chr16:26,175,392...26,190,591
JBrowse link
G Cldn4 claudin 4 multiple interactions ISO rottlerin results in increased expression of and affects the localization of CLDN4 protein CTD PMID:19297429 NCBI chr 5:134,973,977...134,975,788
Ensembl chr 5:134,973,973...134,975,788
JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions ISO rottlerin inhibits the reaction [[ABL1 protein results in increased phosphorylation of and results in decreased activity of PPARG protein] which results in increased expression of COL1A1 protein]; rottlerin inhibits the reaction [Acetaldehyde results in increased expression of COL1A1 mRNA]; rottlerin inhibits the reaction [Acetaldehyde results in increased expression of COL1A1 protein] CTD PMID:17030193 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868
JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions
increases expression
ISO rottlerin inhibits the reaction [Deferoxamine results in increased expression of CXCL8 protein]
rottlerin results in increased expression of CXCL8 protein
CTD PMID:17097691 PMID:37722575 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO rottlerin results in decreased activity of CYP19A1 protein CTD PMID:15955695 NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394
JBrowse link
G Cyp2j9 cytochrome P450, family 2, subfamily j, polypeptide 9 multiple interactions EXP [rottlerin co-treated with Paclitaxel] results in decreased expression of CYP2J2 protein CTD PMID:35995259 NCBI chr 4:96,456,661...96,480,748
Ensembl chr 4:96,456,666...96,479,815
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO rottlerin inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]
rottlerin results in increased expression of DDIT3 protein
rottlerin inhibits the reaction [Cadmium results in increased expression of DDIT3 protein]
CTD PMID:17171638 PMID:22410117 PMID:27658547 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157
JBrowse link
G Ddx3x DEAD box helicase 3, X-linked increases expression ISO Rottlerin increases expression of DDX3X mRNA in liver RGD PMID:29203243 RGD:151356605 NCBI chr  X:13,147,261...13,160,222
Ensembl chr  X:13,147,209...13,160,291
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 decreases phosphorylation ISO rottlerin results in decreased phosphorylation of EEF2 protein CTD PMID:12720544 NCBI chr10:81,012,465...81,018,343
Ensembl chr10:81,012,465...81,018,332
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO rottlerin inhibits the reaction [irinotecan metabolite results in increased phosphorylation of EGFR protein]; rottlerin inhibits the reaction [irinotecan results in increased phosphorylation of EGFR protein]; rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein] CTD PMID:15177934 PMID:15723263 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO rottlerin promotes the reaction [EIF4E protein binds to EIF4EBP1 protein] CTD PMID:19771169 NCBI chr 3:138,231,952...138,265,457
Ensembl chr 3:138,231,940...138,265,457
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO rottlerin inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]; rottlerin promotes the reaction [EIF4E protein binds to EIF4EBP1 protein]
rottlerin inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]
CTD PMID:12720544 PMID:19771169 NCBI chr 8:27,750,355...27,765,684
Ensembl chr 8:27,750,357...27,766,702
JBrowse link
G Elavl1 ELAV like RNA binding protein 1 multiple interactions ISO rottlerin inhibits the reaction [AGT protein affects the localization of ELAVL1 protein] CTD PMID:19246637 NCBI chr 8:4,334,781...4,375,104
Ensembl chr 8:4,335,382...4,375,413
JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions EXP rottlerin inhibits the reaction [PRKCD protein results in increased phosphorylation of FGF1 protein] CTD PMID:15574884 NCBI chr18:38,971,725...39,062,532
Ensembl chr18:38,971,726...39,062,525
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions EXP rottlerin inhibits the reaction [FGF2 protein results in increased activity of RUNX2 protein]; rottlerin inhibits the reaction [FGF2 protein results in increased expression of RUNX2 mRNA] CTD PMID:12403780 NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions ISO rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of FOS protein] CTD PMID:20599481 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO
EXP
rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; rottlerin inhibits the reaction [Plant Extracts results in increased expression of GCLC protein]
rottlerin inhibits the reaction [naringin results in increased expression of GCLC protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin results in increased expression of GCLC mRNA]]; rottlerin affects the reaction [Dextromethorphan affects the expression of GCLC mRNA]; rottlerin inhibits the reaction [Exenatide results in increased expression of GCLC protein]; rottlerin promotes the reaction [Cocaine results in increased expression of GCLC mRNA]; rottlerin promotes the reaction [trimethyltin results in increased expression of GCLC mRNA]
CTD PMID:24211276 PMID:25773745 PMID:25895139 PMID:27939242 PMID:30393195 More... NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin results in increased expression of GCLM mRNA]]; rottlerin affects the reaction [Dextromethorphan affects the expression of GCLM mRNA]; rottlerin promotes the reaction [Cocaine results in increased expression of GCLM mRNA]; rottlerin promotes the reaction [trimethyltin results in increased expression of GCLM mRNA] CTD PMID:25895139 PMID:30393195 PMID:34740715 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381
JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions
increases expression
affects response to substance
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [rottlerin results in increased expression of GDF15 protein]; SB 203580 inhibits the reaction [rottlerin results in increased expression of GDF15 protein]
rottlerin results in increased expression of GDF15 mRNA; rottlerin results in increased expression of GDF15 protein
GDF15 affects the susceptibility to rottlerin
CTD PMID:22410117 NCBI chr 8:71,082,043...71,085,106
Ensembl chr 8:71,082,043...71,085,106
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions ISO
EXP
rottlerin inhibits the reaction [Acrolein results in increased secretion of GPT protein]; rottlerin inhibits the reaction [allyl alcohol results in increased secretion of GPT protein]
rottlerin inhibits the reaction [Cocaine results in increased activity of GPT protein]
CTD PMID:12755590 PMID:30393195 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
JBrowse link
G Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) multiple interactions EXP rottlerin inhibits the reaction [Dextromethorphan promotes the reaction [PRKCD protein modified form binds to GRIN2B protein]] CTD PMID:34740715 NCBI chr 6:135,690,219...136,150,658
Ensembl chr 6:135,690,231...136,150,509
JBrowse link
G Grp gastrin releasing peptide multiple interactions ISO rottlerin promotes the reaction [GRP protein modified form results in increased chemical synthesis of Inositol Phosphates] CTD PMID:18313772 NCBI chr18:66,005,826...66,019,670
Ensembl chr18:66,005,891...66,019,667
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha decreases expression
multiple interactions
ISO rottlerin results in decreased expression of GSK3A protein
[Cadmium co-treated with rottlerin] results in decreased expression of GSK3A protein
CTD PMID:27658547 NCBI chr 7:24,927,683...24,937,276
Ensembl chr 7:24,927,683...24,937,276
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
decreases expression
ISO [Cadmium co-treated with rottlerin] results in decreased expression of GSK3B protein; rottlerin inhibits the reaction [Cadmium results in increased phosphorylation of GSK3B protein]
rottlerin results in decreased expression of GSK3B protein
CTD PMID:27658547 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446
JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression ISO rottlerin results in decreased expression of HAMP mRNA CTD PMID:25633564 NCBI chr 7:30,641,793...30,643,454
Ensembl chr 7:30,641,793...30,643,457
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO
EXP
rottlerin inhibits the reaction [2-butenal results in increased expression of HMOX1 mRNA]; rottlerin inhibits the reaction [2-butenal results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [Acrolein results in increased expression of HMOX1 mRNA]; rottlerin inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [Plant Extracts results in increased expression of HMOX1 protein]
rottlerin inhibits the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA]; rottlerin inhibits the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]; rottlerin inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [Exenatide results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [puerarin results in increased expression of HMOX1 protein]
rottlerin inhibits the reaction [Cadmium results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [naringin results in increased expression of HMOX1 protein]
CTD PMID:17535857 PMID:18048804 PMID:18357586 PMID:20060010 PMID:21238556 More... NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K multiple interactions ISO rottlerin inhibits the reaction [NSC606985 results in decreased expression of HNRNPK protein] CTD PMID:19747914 NCBI chr13:58,538,946...58,551,157
Ensembl chr13:58,538,956...58,551,157
JBrowse link
G Hspa5 heat shock protein 5 increases expression ISO rottlerin results in increased expression of HSPA5 protein CTD PMID:22410117 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559
JBrowse link
G Htr1a 5-hydroxytryptamine (serotonin) receptor 1A multiple interactions EXP rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to HTR1A protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [PRKCD protein binds to HTR1A protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of HTR1A mRNA]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of HTR1A protein] CTD PMID:30366073 NCBI chr13:105,580,040...105,584,630
Ensembl chr13:105,580,147...105,584,630
JBrowse link
G Ifng interferon gamma multiple interactions EXP rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of IFNG protein] CTD PMID:30366073 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
JBrowse link
G Il12b interleukin 12b multiple interactions EXP rottlerin promotes the reaction [Lipopolysaccharides results in increased secretion of IL12B protein] CTD PMID:16330529 NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860
JBrowse link
G Il2 interleukin 2 multiple interactions ISO rottlerin inhibits the reaction [pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]] CTD PMID:16241859 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
EXP
ISO
rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of IL6 protein]
rottlerin results in increased expression of IL6 protein
CTD PMID:30366073 PMID:37722575 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Irs2 insulin receptor substrate 2 decreases expression ISO rottlerin results in decreased expression of IRS2 protein CTD PMID:18308779 NCBI chr 8:11,034,681...11,058,929
Ensembl chr 8:11,034,681...11,058,458
JBrowse link
G Jun jun proto-oncogene multiple interactions ISO rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of JUN protein]; rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of JUN protein]; rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased phosphorylation of JUN protein] CTD PMID:18628248 PMID:20599481 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions ISO rottlerin inhibits the reaction [PRKCD protein promotes the reaction [Lead results in increased localization of LDLR protein]] CTD PMID:20488202 NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215
JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 decreases phosphorylation ISO rottlerin results in decreased phosphorylation of MAP2K1 protein CTD PMID:15949478 NCBI chr 9:64,093,066...64,160,887
Ensembl chr 9:64,093,052...64,160,913
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO
EXP
[Sorafenib co-treated with rottlerin] results in decreased phosphorylation of MAPK1 protein; rottlerin inhibits the reaction [Acetaldehyde results in increased phosphorylation of and results in increased activity of MAPK1 protein]; rottlerin inhibits the reaction [Acrylonitrile results in increased phosphorylation of MAPK1 protein]; rottlerin inhibits the reaction [Curcumin results in increased expression of MAPK1 protein]; rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
rottlerin results in decreased phosphorylation of MAPK1 protein
rottlerin inhibits the reaction [P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK1 protein]]; rottlerin inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; rottlerin promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]
CTD PMID:12720544 PMID:14975926 PMID:15177934 PMID:16959960 PMID:17030193 More... NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk14 mitogen-activated protein kinase 14 decreases phosphorylation ISO rottlerin results in decreased phosphorylation of MAPK14 protein CTD PMID:15949478 NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO
EXP
[Sorafenib co-treated with rottlerin] results in decreased phosphorylation of MAPK3 protein; rottlerin inhibits the reaction [Acetaldehyde results in increased phosphorylation of and results in increased activity of MAPK3 protein]; rottlerin inhibits the reaction [Acrylonitrile results in increased phosphorylation of MAPK3 protein]; rottlerin inhibits the reaction [Curcumin results in increased expression of MAPK3 protein]; rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
rottlerin results in decreased phosphorylation of MAPK3 protein
rottlerin inhibits the reaction [P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK3 protein]]; rottlerin inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; rottlerin promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]
CTD PMID:12720544 PMID:14975926 PMID:15177934 PMID:16959960 PMID:17030193 More... NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO rottlerin inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK8 protein]; rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK8 protein] CTD PMID:15917298 PMID:20599481 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK9 protein] CTD PMID:20599481 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248
JBrowse link
G Mapkapk2 MAP kinase-activated protein kinase 2 decreases activity ISO rottlerin results in decreased activity of MAPKAPK2 protein CTD PMID:10998351 NCBI chr 1:130,981,437...131,025,580
Ensembl chr 1:130,981,437...131,025,563
JBrowse link
G Mapkapk5 MAP kinase-activated protein kinase 5 decreases activity ISO rottlerin results in decreased activity of MAPKAPK5 protein CTD PMID:10998351 NCBI chr 5:121,663,114...121,683,955
Ensembl chr 5:121,663,101...121,683,968
JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate multiple interactions EXP rottlerin inhibits the reaction [sodium arsenate results in increased phosphorylation of MARCKS protein] CTD PMID:11796722 NCBI chr10:37,009,239...37,014,922
Ensembl chr10:37,009,371...37,014,916
JBrowse link
G Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) multiple interactions
increases expression
ISO rottlerin inhibits the reaction [MIF protein results in increased expression of MMP2 protein]
rottlerin results in increased expression of MIF protein
CTD PMID:16872482 PMID:37722575 NCBI chr10:75,695,187...75,696,111
Ensembl chr10:75,695,187...75,696,074
JBrowse link
G Mmp12 matrix metallopeptidase 12 multiple interactions EXP rottlerin inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP12 mRNA] CTD PMID:16571779 NCBI chr 9:7,344,397...7,360,461
Ensembl chr 9:7,344,381...7,369,499
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions EXP rottlerin inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP13 mRNA] CTD PMID:16571779 NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO rottlerin inhibits the reaction [MIF protein results in increased expression of MMP2 protein]; rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP2 protein]; rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 mRNA] CTD PMID:16872482 PMID:20599481 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP rottlerin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA] CTD PMID:15557194 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation
ISO rottlerin inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]
rottlerin results in decreased phosphorylation of MTOR protein
CTD PMID:19771169 PMID:22902833 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions EXP rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to HTR1A protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to PRKCD protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased phosphorylation of and affects the localization of NCF1 protein] CTD PMID:30366073 NCBI chr 5:134,248,907...134,258,479
Ensembl chr 5:134,248,907...134,258,479
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 multiple interactions EXP rottlerin inhibits the reaction [Paraquat affects the localization of NCF2 protein] CTD PMID:17662968 NCBI chr 1:152,675,904...152,712,743
Ensembl chr 1:152,675,945...152,712,742
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO
EXP
rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [Acrolein affects the localization of NFE2L2 protein]; rottlerin inhibits the reaction [Cadmium Chloride affects the localization of NFE2L2 protein]
rottlerin inhibits the reaction [naringin affects the localization of NFE2L2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin affects the localization of and results in increased activity of NFE2L2 protein]]; [rottlerin co-treated with Dextromethorphan] results in increased activity of and affects the localization of NFE2L2 protein; rottlerin promotes the reaction [Cocaine results in increased activity of and affects the localization of NFE2L2 protein]; rottlerin promotes the reaction [trimethyltin affects the localization of and results in increased activity of NFE2L2 protein]
CTD PMID:18048804 PMID:21787730 PMID:24211276 PMID:25773745 PMID:25895139 More... NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Ngf nerve growth factor multiple interactions EXP rottlerin inhibits the reaction [NGF results in increased phosphorylation of TRPV1 protein] CTD PMID:16319926 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions ISO rottlerin inhibits the reaction [Paraquat results in increased expression of NOX1 mRNA]; rottlerin inhibits the reaction [Paraquat results in increased expression of NOX1 protein] CTD PMID:23827392 NCBI chr  X:132,987,170...133,038,455
Ensembl chr  X:132,987,170...133,122,705
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions ISO rottlerin inhibits the reaction [Cadmium Chloride results in increased expression of NQO1 mRNA]; rottlerin inhibits the reaction [Cadmium Chloride results in increased expression of NQO1 protein]; rottlerin inhibits the reaction [Plant Extracts results in increased expression of NQO1 protein] CTD PMID:21787730 PMID:30626086 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Nts neurotensin multiple interactions
increases activity
ISO rottlerin affects the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates]; rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]; rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]
rottlerin results in increased activity of NTS protein
CTD PMID:15177934 PMID:18313772 NCBI chr10:102,317,617...102,326,294
Ensembl chr10:102,317,617...102,326,347
JBrowse link
G Ocln occludin affects localization ISO rottlerin affects the localization of OCLN protein modified form CTD PMID:19297429 NCBI chr13:100,633,012...100,689,226
Ensembl chr13:100,633,015...100,689,226
JBrowse link
G Odc1 ornithine decarboxylase, structural 1 multiple interactions ISO rottlerin inhibits the reaction [PRL protein results in increased activity of ODC1 protein] CTD PMID:16520895 NCBI chr12:17,594,906...17,601,503
Ensembl chr12:17,594,795...17,601,506
JBrowse link
G P2ry1 purinergic receptor P2Y, G-protein coupled 1 multiple interactions ISO rottlerin inhibits the reaction [P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK1 protein]]; rottlerin inhibits the reaction [P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK3 protein]] CTD PMID:17620283 NCBI chr 3:60,910,206...60,916,403
Ensembl chr 3:60,910,216...60,916,403
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage
multiple interactions
ISO
EXP
rottlerin results in increased cleavage of PARP1 protein
rottlerin inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]
[rottlerin co-treated with Paclitaxel] results in increased cleavage of PARP1 protein
CTD PMID:22902833 PMID:27658547 PMID:35995259 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Pld1 phospholipase D1 multiple interactions ISO rottlerin inhibits the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]] CTD PMID:17640750 NCBI chr 3:27,992,636...28,187,388
Ensembl chr 3:27,992,844...28,187,511
JBrowse link
G Plscr1 phospholipid scramblase 1 multiple interactions ISO rottlerin inhibits the reaction [IFNA2 protein results in increased expression of PLSCR1 mRNA]; rottlerin inhibits the reaction [IFNA2 protein results in increased expression of PLSCR1 protein] CTD PMID:16260419 NCBI chr 9:92,132,265...92,154,034
Ensembl chr 9:92,131,803...92,154,331
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions ISO rottlerin inhibits the reaction [[ABL1 protein results in increased phosphorylation of and results in decreased activity of PPARG protein] which results in increased expression of COL1A1 protein] CTD PMID:17030193 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions EXP rottlerin inhibits the reaction [sodium arsenate results in increased expression of PRDX1 mRNA]; rottlerin inhibits the reaction [sodium arsenate results in increased expression of PRDX1 protein] CTD PMID:11796722 NCBI chr 4:116,542,796...116,557,196
Ensembl chr 4:116,542,741...116,558,019
JBrowse link
G Prkcd protein kinase C, delta multiple interactions
decreases activity
decreases phosphorylation
decreases response to substance
ISO
EXP
[rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [benz(a)anthracene results in increased expression of TFF1 mRNA]]; rottlerin inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; rottlerin inhibits the reaction [IFNA2 protein results in increased phosphorylation of and results in increased activity of PRKCD protein]; rottlerin inhibits the reaction [NSC606985 results in increased activity of and results in increased cleavage of PRKCD protein]
[rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased activity of TH protein]; [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased expression of DAT protein]; [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased expression of SLC18A2 protein]; [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased expression of TH protein]; [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in increased metabolism of Dopamine]; [rottlerin results in decreased activity of PRKCD protein] which results in decreased susceptibility to Methamphetamine; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to PRKCD protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [PRKCD protein binds to HTR1A protein]]; rottlerin inhibits the reaction [Dextromethorphan promotes the reaction [PRKCD protein modified form binds to GRIN2B protein]]; rottlerin inhibits the reaction [Dextromethorphan results in increased phosphorylation of PRKCD protein]; rottlerin inhibits the reaction [p-Chloroamphetamine results in increased phosphorylation of PRKCD protein]; rottlerin inhibits the reaction [PRKCD protein results in increased phosphorylation of FGF1 protein]; rottlerin inhibits the reaction [trimethyltin results in increased expression of and results in increased cleavage of PRKCD protein]
[rottlerin results in decreased activity of PRKCD protein] which results in decreased susceptibility to 2-methylcyclopentadienyl manganese tricarbonyl; rottlerin inhibits the reaction [2-methylcyclopentadienyl manganese tricarbonyl results in increased cleavage of and results in increased activity of PRKCD protein]; rottlerin inhibits the reaction [Cadmium results in increased phosphorylation of PRKCD protein]; rottlerin inhibits the reaction [manganese chloride results in increased activity of PRKCD protein]; rottlerin inhibits the reaction [naringin results in increased phosphorylation of PRKCD protein]; rottlerin inhibits the reaction [PRKCD protein promotes the reaction [Lead results in increased localization of APP protein]]; rottlerin inhibits the reaction [PRKCD protein promotes the reaction [Lead results in increased localization of LDLR protein]]; rottlerin inhibits the reaction [sodium arsenite results in increased phosphorylation of PRKCD protein]
rottlerin results in decreased phosphorylation of PRKCD protein
PRKCD protein results in decreased susceptibility to rottlerin
CTD PMID:11880503 PMID:12720544 PMID:15574884 PMID:15681813 PMID:15949478 More... NCBI chr14:30,317,310...30,348,637
Ensembl chr14:30,317,311...30,348,167
JBrowse link
G Prkcq protein kinase C, theta decreases activity ISO rottlerin results in decreased activity of PRKCQ protein CTD PMID:15691325 NCBI chr 2:11,176,922...11,306,033
Ensembl chr 2:11,176,919...11,306,033
JBrowse link
G Prl prolactin multiple interactions ISO rottlerin inhibits the reaction [PRL protein results in increased activity of ODC1 protein] CTD PMID:16520895 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
rottlerin inhibits the reaction [Acrolein results in increased expression of PTGS2 mRNA]; rottlerin inhibits the reaction [Acrolein results in increased expression of PTGS2 protein]; rottlerin inhibits the reaction [manganese chloride results in increased expression of PTGS2 protein]; rottlerin inhibits the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]]
rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of PTGS2 protein]
CTD PMID:17363696 PMID:17640750 PMID:19084589 PMID:30366073 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Raf1 v-raf-leukemia viral oncogene 1 decreases phosphorylation ISO rottlerin results in decreased phosphorylation of RAF1 protein CTD PMID:15949478 NCBI chr 6:115,595,530...115,653,596
Ensembl chr 6:115,595,028...115,653,596
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO rottlerin results in decreased phosphorylation of RB1 protein CTD PMID:15949478 NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 multiple interactions
decreases activity
ISO rottlerin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]
rottlerin results in decreased activity of RPS6KB1 protein
CTD PMID:12720544 NCBI chr11:86,389,695...86,435,711
Ensembl chr11:86,389,697...86,435,631
JBrowse link
G Rps6kb2 ribosomal protein S6 kinase, polypeptide 2 multiple interactions
decreases activity
ISO rottlerin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB2 protein]
rottlerin results in decreased activity of RPS6KB2 protein
CTD PMID:12720544 NCBI chr19:4,206,791...4,213,382
Ensembl chr19:4,203,990...4,213,353
JBrowse link
G Runx2 runt related transcription factor 2 multiple interactions EXP rottlerin inhibits the reaction [FGF2 protein results in increased activity of RUNX2 protein]; rottlerin inhibits the reaction [FGF2 protein results in increased expression of RUNX2 mRNA] CTD PMID:12403780 NCBI chr17:44,806,873...45,125,518
Ensembl chr17:44,806,874...45,125,684
JBrowse link
G Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 multiple interactions EXP [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased expression of SLC18A2 protein] CTD PMID:22512859 NCBI chr19:59,249,310...59,284,444
Ensembl chr19:59,249,328...59,284,444
JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 multiple interactions EXP [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased expression of DAT protein] CTD PMID:22512859 NCBI chr13:73,684,270...73,726,791
Ensembl chr13:73,684,866...73,726,791
JBrowse link
G Snai1 snail family zinc finger 1 decreases expression
multiple interactions
EXP rottlerin results in decreased expression of SNAI1 protein
rottlerin promotes the reaction [Paclitaxel results in decreased expression of SNAI1 protein]
CTD PMID:35995259 NCBI chr 2:167,380,115...167,384,734
Ensembl chr 2:167,380,115...167,384,734
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions ISO rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SOD2 mRNA]; rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SOD2 protein] CTD PMID:21705328 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
G Sts steroid sulfatase multiple interactions ISO rottlerin inhibits the reaction [Tretinoin results in increased activity of STS protein] CTD PMID:16178010 NCBI chr  X:168,856,332...169,015,037
Ensembl chr  X:168,909,030...169,014,924
JBrowse link
G Tfap2a transcription factor AP-2, alpha multiple interactions ISO rottlerin inhibits the reaction [TFAP2A protein binds to ULBP1 promoter] CTD PMID:21499124 NCBI chr13:40,867,278...40,891,715
Ensembl chr13:40,868,778...40,891,852
JBrowse link
G Tff1 trefoil factor 1 multiple interactions ISO [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [benz(a)anthracene results in increased expression of TFF1 mRNA]] CTD PMID:22643241 NCBI chr17:31,380,369...31,384,034
Ensembl chr17:31,380,369...31,384,251
JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO rottlerin inhibits the reaction [irinotecan metabolite results in increased secretion of TGFA protein]; rottlerin inhibits the reaction [irinotecan results in increased secretion of TGFA protein] CTD PMID:15723263 NCBI chr 6:86,172,020...86,252,726
Ensembl chr 6:86,172,205...86,252,701
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO
EXP
rottlerin inhibits the reaction [manganese chloride results in decreased activity of TH protein]
[rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased activity of TH protein]; [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased expression of TH protein]
CTD PMID:21310168 PMID:22512859 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865
JBrowse link
G Tjp1 tight junction protein 1 affects localization ISO rottlerin affects the localization of TJP1 protein CTD PMID:19297429 NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP rottlerin inhibits the reaction [NGF results in increased phosphorylation of TRPV1 protein] CTD PMID:16319926 NCBI chr11:73,124,975...73,152,148
Ensembl chr11:73,125,118...73,152,068
JBrowse link
G Tyr tyrosinase decreases expression EXP rottlerin results in decreased expression of TYR mRNA; rottlerin results in decreased expression of TYR protein CTD PMID:21071833 NCBI chr 7:87,073,979...87,142,637
Ensembl chr 7:87,073,979...87,142,720
JBrowse link
G Ulbp1 UL16 binding protein 1 increases expression
multiple interactions
ISO rottlerin results in increased expression of ULBP1 mRNA
rottlerin inhibits the reaction [TFAP2A protein binds to ULBP1 promoter]
CTD PMID:21499124 PMID:21951556 NCBI chr10:7,394,873...7,423,643
Ensembl chr10:7,390,362...7,423,638
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO rottlerin inhibits the reaction [VEGFA protein results in increased abundance of phosphatidylbutanol] CTD PMID:14704231 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
JBrowse link
G Vim vimentin multiple interactions
decreases expression
EXP rottlerin promotes the reaction [Paclitaxel results in decreased expression of VIM protein]
rottlerin results in decreased expression of VIM protein
CTD PMID:35995259 NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO rottlerin results in decreased expression of XIAP protein CTD PMID:22902833 NCBI chr  X:41,148,483...41,198,541
Ensembl chr  X:41,148,556...41,198,533
JBrowse link
Sophoricoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aif1 allograft inflammatory factor 1 multiple interactions EXP sophoricoside inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of AIF1 protein] CTD PMID:37741537 NCBI chr17:35,389,967...35,394,977
Ensembl chr17:35,389,967...35,395,044
JBrowse link
G Bax BCL2-associated X protein multiple interactions EXP dorsomorphin inhibits the reaction [sophoricoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]]; Sirolimus inhibits the reaction [sophoricoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]]; sophoricoside inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BAX protein]; sophoricoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein] CTD PMID:37741537 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions EXP dorsomorphin inhibits the reaction [sophoricoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]]; Sirolimus inhibits the reaction [sophoricoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]]; sophoricoside inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BCL2 protein]; sophoricoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein] CTD PMID:37741537 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Casp3 caspase 3 multiple interactions EXP sophoricoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of CASP3 protein] CTD PMID:37741537 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Cdh1 cadherin 1 decreases expression EXP sophoricoside results in decreased expression of CDH1 CTD PMID:24877640 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878
JBrowse link
G Esr1 estrogen receptor 1 (alpha) decreases expression EXP sophoricoside results in decreased expression of ESR1 CTD PMID:24877640 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
JBrowse link
G Il6 interleukin 6 multiple interactions EXP sophoricoside inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL6 mRNA]; sophoricoside inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; sophoricoside inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:37741537 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Itgb3 integrin beta 3 decreases expression EXP sophoricoside results in decreased expression of ITGB3 CTD PMID:24877640 NCBI chr11:104,498,826...104,561,302
Ensembl chr11:104,498,826...104,561,302
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression EXP sophoricoside results in decreased expression of MMP2 CTD PMID:24877640 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP sophoricoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of MTOR protein] CTD PMID:37741537 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP sophoricoside inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of and results in increased phosphorylation of NFKBIA protein]; sophoricoside inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in increased phosphorylation of NFKBIA protein] CTD PMID:37741537 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP sophoricoside inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NOS2 mRNA]; sophoricoside inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; sophoricoside inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:37741537 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Pgr progesterone receptor increases expression EXP sophoricoside results in increased expression of PGR CTD PMID:24877640 NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP sophoricoside inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PTGS2 mRNA]; sophoricoside inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; sophoricoside inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:37741537 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP sophoricoside inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased phosphorylation of RELA protein]; sophoricoside inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] CTD PMID:37741537 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP sophoricoside inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein] CTD PMID:37741537 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP sophoricoside inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF mRNA]; sophoricoside inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; sophoricoside inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:37741537 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
teprenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO geranylgeranylacetone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of and results in increased cleavage of CASP3 protein] CTD PMID:34732784 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO
EXP
geranylgeranylacetone inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]
geranylgeranylacetone inhibits the reaction [Bleomycin results in decreased expression of CDH1 mRNA]; geranylgeranylacetone inhibits the reaction [Bleomycin results in decreased expression of CDH1 protein]
CTD PMID:37307957 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878
JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions EXP geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of COL1A1 protein] CTD PMID:37307957 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868
JBrowse link
G Col1a2 collagen, type I, alpha 2 multiple interactions EXP geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of COL1A2 mRNA]; geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of COL1A2 protein] CTD PMID:37307957 NCBI chr 6:4,505,618...4,541,543
Ensembl chr 6:4,504,814...4,541,544
JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 increases expression
multiple interactions
EXP geranylgeranylacetone results in increased expression of DLG1 mRNA; geranylgeranylacetone results in increased expression of DLG1 protein
geranylgeranylacetone promotes the reaction [[HSF1 protein binds to DLG1 promoter] which results in increased expression of DLG1 mRNA]; Niacinamide inhibits the reaction [geranylgeranylacetone results in increased expression of DLG1 mRNA]; resveratrol promotes the reaction [geranylgeranylacetone results in increased expression of DLG1 mRNA]
CTD PMID:21232033 NCBI chr16:31,482,261...31,692,174
Ensembl chr16:31,482,261...31,693,947
JBrowse link
G Edn1 endothelin 1 decreases expression ISO geranylgeranylacetone results in decreased expression of EDN1 protein CTD PMID:16324314 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of FN1 mRNA]; geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of FN1 protein] CTD PMID:37307957 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359
JBrowse link
G Hsf1 heat shock factor 1 multiple interactions
affects response to substance
increases expression
EXP geranylgeranylacetone promotes the reaction [[HSF1 protein binds to DLG1 promoter] which results in increased expression of DLG1 mRNA]
HSF1 protein affects the susceptibility to geranylgeranylacetone
geranylgeranylacetone results in increased expression of HSF1 protein
CTD PMID:17189318 PMID:21232033 NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113
JBrowse link
G Hspa1a heat shock protein 1A multiple interactions EXP
ISO
geranylgeranylacetone promotes the reaction [Bleomycin results in increased expression of HSPA1A mRNA]; geranylgeranylacetone promotes the reaction [Ethanol results in increased expression of HSPA1A protein]
geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1A mRNA]; geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1A protein]
CTD PMID:17189318 PMID:37307957 NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132
JBrowse link
G Hspa1b heat shock protein 1B multiple interactions EXP
ISO
[Tetrachlorodibenzodioxin co-treated with geranylgeranylacetone] results in increased expression of HSPA1B mRNA; [Tetrachlorodibenzodioxin co-treated with geranylgeranylacetone] results in increased expression of HSPA1B protein; geranylgeranylacetone promotes the reaction [Bleomycin results in increased expression of HSPA1B mRNA]
geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1B mRNA]; geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1B protein]
CTD PMID:15340226 PMID:37307957 NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214
JBrowse link
G Kcna5 potassium voltage-gated channel, shaker-related subfamily, member 5 increases expression EXP geranylgeranylacetone results in increased expression of KCNA5 protein CTD PMID:21232033 NCBI chr 6:126,509,514...126,512,518
Ensembl chr 6:126,509,514...126,512,375
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO geranylgeranylacetone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of MAP3K5 protein] CTD PMID:34732784 NCBI chr10:19,809,847...20,018,496
Ensembl chr10:19,810,218...20,018,499
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO
EXP
geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of NOX4 mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of NOX4 protein]
geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of NOX4 mRNA]
CTD PMID:37307957 NCBI chr 7:86,893,638...87,047,918
Ensembl chr 7:86,895,304...87,047,918
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions ISO geranylgeranylacetone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of PARP1 protein] CTD PMID:34732784 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO
EXP
geranylgeranylacetone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of RELA protein]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of RELA mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of RELA protein]
geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of RELA mRNA]
CTD PMID:34732784 PMID:37307957 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO geranylgeranylacetone inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of NOX4 mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of NOX4 protein]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of RELA mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of RELA protein]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1A mRNA]; geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1A protein]; geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1B mRNA]; geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1B protein] CTD PMID:37307957 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO geranylgeranylacetone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TXN mRNA]; geranylgeranylacetone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TXN protein] CTD PMID:34732784 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411
JBrowse link
G Vim vimentin multiple interactions EXP
ISO
geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of VIM mRNA]; geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of VIM protein]
geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]
CTD PMID:37307957 NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637
JBrowse link
tomelukast term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death increases expression ISO LY 171883 results in increased expression of BAD protein CTD PMID:12065618 NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267
JBrowse link
G Bax BCL2-associated X protein increases expression ISO LY 171883 results in increased expression of BAX protein CTD PMID:12065618 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 multiple interactions EXP
ISO
[LY 171883 binds to and results in decreased activity of CYSLTR1 protein] which results in decreased abundance of Leukotriene B4; LY 171883 binds to and results in decreased activity of CYSLTR1 protein
LY 171883 binds to and results in increased activity of CYSLTR1 protein; LY 171883 inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]
CTD PMID:8014878 PMID:14718577 NCBI chr  X:105,617,952...105,647,329
Ensembl chr  X:105,617,952...105,647,285
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO LY 171883 binds to and results in increased activity of PPARA protein CTD PMID:15491415 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions EXP LY 171883 results in increased activity of [PPARG protein co-treated with RXRA protein] CTD PMID:8700121 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions EXP LY 171883 results in increased activity of [PPARG protein co-treated with RXRA protein] CTD PMID:8700121 NCBI chr 2:27,566,457...27,653,331
Ensembl chr 2:27,566,452...27,652,969
JBrowse link
undecan-2-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO undecan-2-one binds to and results in decreased activity of AR protein CTD PMID:27633901 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821
JBrowse link
G Esr2 estrogen receptor 2 (beta) multiple interactions ISO undecan-2-one binds to and results in decreased activity of ESR2 protein CTD PMID:27633901 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
undecan-2-one promotes the reaction [NFE2L2 promotes the reaction [Particulate Matter results in increased expression of HMOX1 protein]]
undecan-2-one results in increased expression of HMOX1 protein
CTD PMID:35285579 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Il18 interleukin 18 multiple interactions EXP undecan-2-one inhibits the reaction [Particulate Matter results in increased expression of IL18 protein] CTD PMID:35285579 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
undecan-2-one inhibits the reaction [Particulate Matter results in increased expression of IL1B protein] CTD PMID:35285579 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO
undecan-2-one inhibits the reaction [Particulate Matter results in increased expression of IL6 protein] CTD PMID:35285579 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions EXP
ISO
undecan-2-one results in increased expression of and affects the localization of NFE2L2 protein
[Particulate Matter co-treated with undecan-2-one] results in increased expression of NFE2L2 protein; undecan-2-one inhibits the reaction [Particulate Matter results in decreased expression of NFE2L2 protein]; undecan-2-one promotes the reaction [NFE2L2 promotes the reaction [Particulate Matter results in increased expression of HMOX1 protein]]
CTD PMID:35285579 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO
EXP
undecan-2-one inhibits the reaction [Particulate Matter results in increased phosphorylation of NFKBIA protein] CTD PMID:35285579 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO undecan-2-one binds to and results in decreased activity of NR3C1 protein CTD PMID:27633901 NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO
EXP
undecan-2-one inhibits the reaction [Particulate Matter results in increased expression of RELA protein modified form]; undecan-2-one inhibits the reaction [Particulate Matter results in increased expression of RELA protein] CTD PMID:35285579 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
undecan-2-one inhibits the reaction [Particulate Matter results in increased expression of TNF protein] CTD PMID:35285579 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
usnic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO usnic acid results in decreased phosphorylation of and results in decreased expression of AKT1 protein CTD PMID:25078063 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression
ISO 2-aminoethoxydiphenyl borate inhibits the reaction [usnic acid results in increased expression of ATF4 protein] CTD PMID:25870318 NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742
JBrowse link
G Atm ataxia telangiectasia mutated increases phosphorylation
multiple interactions
ISO usnic acid results in increased phosphorylation of ATM protein
Acetylcysteine inhibits the reaction [usnic acid results in increased phosphorylation of ATM protein]
CTD PMID:31715134 NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040
JBrowse link
G Bax BCL2-associated X protein decreases expression
increases expression
ISO usnic acid results in decreased expression of BAX protein
usnic acid results in increased expression of BAX protein
CTD PMID:22285236 PMID:31715134 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO usnic acid results in decreased expression of BCL2 protein CTD PMID:22285236 PMID:25078063 PMID:31715134 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO 3-methyladenine promotes the reaction [usnic acid results in increased activity of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [usnic acid results in increased activity of CASP3 protein]; Chloroquine promotes the reaction [usnic acid results in increased activity of CASP3 protein]; pyrazolanthrone promotes the reaction [usnic acid results in increased activity of CASP3 protein] CTD PMID:22285236 PMID:25078063 PMID:25870318 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp4 caspase 4, apoptosis-related cysteine peptidase increases cleavage ISO usnic acid results in increased cleavage of CASP4 protein CTD PMID:25870318 NCBI chr 9:5,308,816...5,336,791
Ensembl chr 9:5,308,828...5,336,783
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO 3-methyladenine promotes the reaction [usnic acid results in increased activity of CASP7 protein]; 4-phenylbutyric acid inhibits the reaction [usnic acid results in increased activity of CASP7 protein]; Chloroquine promotes the reaction [usnic acid results in increased activity of CASP7 protein]; pyrazolanthrone promotes the reaction [usnic acid results in increased activity of CASP7 protein] CTD PMID:25078063 PMID:25870318 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776
JBrowse link
G Cat catalase multiple interactions ISO usnic acid inhibits the reaction [Indomethacin results in increased activity of CAT protein] CTD PMID:16169175 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Ccl21a C-C motif chemokine ligand 21 (serine) multiple interactions
increases expression
ISO [usnic acid co-treated with Lipopolysaccharides] results in increased expression of CCL21 mRNA
usnic acid results in increased expression of CCL21 mRNA
CTD PMID:21953288 PMID:22777745 NCBI chr 4:42,772,860...42,773,991
Ensembl chr 4:42,772,860...42,773,993
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in increased expression of CCL4 mRNA CTD PMID:22777745 NCBI chr11:83,553,410...83,555,509
Ensembl chr11:83,553,410...83,555,509
JBrowse link
G Ccnc cyclin C multiple interactions
increases expression
ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CCNC mRNA
usnic acid results in increased expression of CCNC mRNA
CTD PMID:21953288 PMID:22777745 NCBI chr 4:21,727,705...21,759,917
Ensembl chr 4:21,727,701...21,759,922
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO usnic acid results in decreased expression of CCND1 protein CTD PMID:27369375 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO usnic acid results in decreased expression of CCND3 protein CTD PMID:27369375 NCBI chr17:47,815,976...47,910,614
Ensembl chr17:47,815,976...47,910,616
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO usnic acid results in decreased expression of CDK2 protein CTD PMID:27369375 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900
JBrowse link
G Cdk4 cyclin dependent kinase 4 decreases expression ISO usnic acid results in decreased expression of CDK4 protein CTD PMID:27369375 NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789
JBrowse link
G Cdk6 cyclin dependent kinase 6 decreases expression ISO usnic acid results in decreased expression of CDK6 protein CTD PMID:27369375 NCBI chr 5:3,391,004...3,581,008
Ensembl chr 5:3,391,485...3,581,008
JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO usnic acid results in increased expression of CHEK1 protein modified form CTD PMID:27369375 NCBI chr 9:36,619,935...36,637,897
Ensembl chr 9:36,619,778...36,638,361
JBrowse link
G Chek2 checkpoint kinase 2 increases expression
multiple interactions
ISO usnic acid results in increased expression of CHEK2 protein; usnic acid results in increased expression of CHEK2 protein modified form
Acetylcysteine inhibits the reaction [usnic acid results in increased expression of CHEK2 protein]
CTD PMID:27369375 PMID:31715134 NCBI chr 5:110,987,668...111,022,006
Ensembl chr 5:110,987,845...111,022,011
JBrowse link
G Cryab crystallin, alpha B multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CRYAB mRNA CTD PMID:22777745 NCBI chr 9:50,657,251...50,667,936
Ensembl chr 9:50,662,625...50,667,936
JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) multiple interactions
decreases expression
ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CSF2 mRNA
usnic acid results in decreased expression of CSF2 mRNA
CTD PMID:21953288 PMID:22777745 NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CXCL10 mRNA CTD PMID:22777745 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression ISO usnic acid results in decreased expression of CYP1A1 mRNA CTD PMID:21953288 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases expression
ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CYP2E1 mRNA
usnic acid results in decreased expression of CYP2E1 mRNA
CTD PMID:21953288 PMID:22777745 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CYP7A1 mRNA CTD PMID:22777745 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633
JBrowse link
G Ddb1 damage specific DNA binding protein 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of DDB1 mRNA CTD PMID:22777745 NCBI chr19:10,582,961...10,607,186
Ensembl chr19:10,582,691...10,607,183
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO 2-aminoethoxydiphenyl borate inhibits the reaction [usnic acid results in increased expression of DDIT3 protein]
usnic acid results in increased expression of DDIT3 mRNA; usnic acid results in increased expression of DDIT3 protein
CTD PMID:25870318 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation ISO usnic acid results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:25078063 NCBI chr 8:27,750,355...27,765,684
Ensembl chr 8:27,750,357...27,766,702
JBrowse link
G Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of ERCC1 mRNA CTD PMID:22777745 NCBI chr 7:19,079,016...19,090,449
Ensembl chr 7:19,078,703...19,090,449
JBrowse link
G Fasl Fas ligand multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of FASLG mRNA CTD PMID:22777745 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064
JBrowse link
G Fmo1 flavin containing monooxygenase 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of FMO1 mRNA CTD PMID:22777745 NCBI chr 1:162,657,130...162,694,170
Ensembl chr 1:162,657,130...162,694,179
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO usnic acid results in increased expression of GCLC mRNA; usnic acid results in increased expression of GCLC protein
NFE2L2 protein promotes the reaction [usnic acid results in increased expression of GCLC protein]
CTD PMID:27369375 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in increased expression of GPX1 mRNA CTD PMID:22777745 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542
JBrowse link
G Gsr glutathione reductase multiple interactions
increases expression
ISO [usnic acid co-treated with Lipopolysaccharides] results in increased expression of GSR mRNA
usnic acid results in increased expression of GSR protein
CTD PMID:22777745 PMID:27369375 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions
ISO usnic acid results in increased expression of H2AX protein; usnic acid results in increased expression of H2AX protein modified form
Acetylcysteine inhibits the reaction [usnic acid results in increased expression of H2AX protein]; NFE2L2 protein inhibits the reaction [usnic acid results in increased expression of H2AX protein modified form]
CTD PMID:27369375 PMID:31715134 NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of HSP90AB1 mRNA CTD PMID:22777745 NCBI chr17:45,878,704...45,884,187
Ensembl chr17:45,878,701...45,884,197
JBrowse link
G Hspa1a heat shock protein 1A multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in increased expression of HSPA1A mRNA CTD PMID:22777745 NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132
JBrowse link
G Hspa2 heat shock protein 2 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of HSPA2 mRNA CTD PMID:22777745 NCBI chr12:76,450,688...76,453,712
Ensembl chr12:76,450,950...76,453,712
JBrowse link
G Hspa5 heat shock protein 5 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of HSPA5 mRNA CTD PMID:22777745 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559
JBrowse link
G Hsph1 heat shock 105kDa/110kDa protein 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in increased expression of HSPH1 mRNA CTD PMID:22777745 NCBI chr 5:149,540,308...149,562,594
Ensembl chr 5:149,537,752...149,559,841
JBrowse link
G Il18 interleukin 18 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in increased expression of IL18 mRNA CTD PMID:22777745 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of IL1A mRNA CTD PMID:22777745 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of IL1B mRNA CTD PMID:22777745 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of IL6 mRNA CTD PMID:22777745 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Lta lymphotoxin A multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of LTA mRNA CTD PMID:22777745 NCBI chr17:35,422,141...35,424,568
Ensembl chr17:35,422,141...35,424,327
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation ISO usnic acid results in increased phosphorylation of MAPK1 protein CTD PMID:25078063 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases phosphorylation ISO usnic acid results in increased phosphorylation of MAPK3 protein CTD PMID:25078063 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mcl1 myeloid cell leukemia sequence 1 multiple interactions
decreases expression
ISO 3-methyladenine promotes the reaction [usnic acid results in decreased expression of MCL1 protein]; Chloroquine promotes the reaction [usnic acid results in decreased expression of MCL1 protein]; pyrazolanthrone promotes the reaction [usnic acid results in decreased expression of MCL1 protein] CTD PMID:25078063 NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO usnic acid inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:16169175 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO usnic acid results in decreased phosphorylation of and results in decreased expression of MTOR protein CTD PMID:25078063 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO NFE2L2 protein inhibits the reaction [usnic acid results in increased expression of H2AX protein modified form]; NFE2L2 protein promotes the reaction [usnic acid results in increased expression of GCLC protein]; usnic acid results in increased expression of and affects the localization of NFE2L2 protein CTD PMID:27369375 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of NOS2 mRNA
usnic acid inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]
CTD PMID:16169175 PMID:22777745 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression ISO usnic acid results in increased expression of NQO1 protein CTD PMID:27369375 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Orai1 ORAI calcium release-activated calcium modulator 1 increases expression
multiple interactions
ISO usnic acid results in increased expression of ORAI1 protein
2-aminoethoxydiphenyl borate inhibits the reaction [usnic acid results in increased expression of ORAI1 protein]
CTD PMID:25870318 NCBI chr 5:123,153,078...123,168,515
Ensembl chr 5:123,153,137...123,168,519
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO usnic acid results in increased cleavage of PARP1 protein CTD PMID:31715134 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase, isoenzyme 1 decreases phosphorylation ISO usnic acid results in decreased phosphorylation of PDK1 protein CTD PMID:25078063 NCBI chr 2:71,703,398...71,734,202
Ensembl chr 2:71,703,568...71,734,202
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of POR mRNA CTD PMID:22777745 NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180
JBrowse link
G Prkdc protein kinase, DNA activated, catalytic polypeptide increases expression
multiple interactions
ISO usnic acid results in increased expression of PRKDC protein
Acetylcysteine inhibits the reaction [usnic acid results in increased expression of PRKDC protein]
CTD PMID:31715134 NCBI chr16:15,455,698...15,660,103
Ensembl chr16:15,455,730...15,660,099
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of PTGS1 mRNA CTD PMID:22777745 NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284
JBrowse link
G Rad50 RAD50 double strand break repair protein multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of RAD50 mRNA CTD PMID:22777745 NCBI chr11:53,540,346...53,598,146
Ensembl chr11:53,540,346...53,598,146
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 decreases phosphorylation ISO usnic acid results in decreased phosphorylation of RPS6KB1 protein CTD PMID:25078063 NCBI chr11:86,389,695...86,435,711
Ensembl chr11:86,389,697...86,435,631
JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of SERPINE1 mRNA CTD PMID:22777745 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122
JBrowse link
G Sqstm1 sequestosome 1 increases degradation ISO usnic acid results in increased degradation of SQSTM1 protein CTD PMID:25078063 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654
JBrowse link
G Stim1 stromal interaction molecule 1 increases expression ISO usnic acid results in increased expression of STIM1 protein CTD PMID:25870318 NCBI chr 7:101,909,279...102,086,525
Ensembl chr 7:101,917,013...102,086,526
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of TNF mRNA CTD PMID:22777745 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Trp53 transformation related protein 53 decreases expression
multiple interactions
increases expression
ISO usnic acid results in decreased expression of TP53 protein
Acetylcysteine inhibits the reaction [usnic acid results in increased expression of TP53 protein]
CTD PMID:22285236 PMID:31715134 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase 1 family, polypeptide A5 multiple interactions
increases expression
ISO [usnic acid co-treated with Lipopolysaccharides] results in increased expression of UGT1A4 mRNA
usnic acid results in increased expression of UGT1A4 mRNA
CTD PMID:21953288 PMID:22777745 NCBI chr 1:88,093,734...88,147,724
Ensembl chr 1:88,093,734...88,146,719
JBrowse link
G Xbp1 X-box binding protein 1 increases splicing ISO usnic acid results in increased splicing of XBP1 mRNA CTD PMID:25870318 NCBI chr11:5,470,641...5,475,993
Ensembl chr11:5,470,659...5,475,893
JBrowse link
G Xrcc1 X-ray repair complementing defective repair in Chinese hamster cells 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of XRCC1 mRNA CTD PMID:22777745 NCBI chr 7:24,246,124...24,272,863
Ensembl chr 7:24,245,714...24,272,865
JBrowse link
warfarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A affects response to substance
increases expression
ISO
EXP
ABCB1 polymorphism affects the susceptibility to Warfarin
Warfarin results in increased expression of ABCB1A mRNA
CTD PMID:24092646 PMID:25312789 PMID:27397090 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
JBrowse link
G Abcc6 ATP-binding cassette, sub-family C member 6 multiple interactions
increases response to substance
EXP [Magnesium deficiency co-treated with Phosphates] promotes the reaction [ABCC6 gene mutant form results in increased susceptibility to Warfarin] CTD PMID:23415960 NCBI chr 7:45,625,804...45,679,915
Ensembl chr 7:45,616,979...45,679,726
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) affects response to substance ISO ABCG2 SNP affects the susceptibility to Warfarin CTD PMID:25300812 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661
JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions ISO [Warfarin co-treated with Vitamin K co-treated with Quercetin] results in increased expression of ACTA2 mRNA CTD PMID:23117658 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990
JBrowse link
G Actb actin, beta increases expression
decreases expression
EXP Warfarin results in increased expression of ACTB mRNA
Warfarin results in decreased expression of ACTB mRNA
CTD PMID:20493250 NCBI chr 5:142,888,870...142,892,509
Ensembl chr 5:142,888,870...142,892,509
JBrowse link
G Actr3 ARP3 actin-related protein 3 increases expression EXP Warfarin results in increased expression of ACTR3 mRNA CTD PMID:20493250 NCBI chr 1:125,320,642...125,363,464
Ensembl chr 1:125,320,642...125,363,464
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression
multiple interactions
ISO Warfarin results in increased expression of ADIPOQ protein
Warfarin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of ADIPOQ protein]
CTD PMID:27488359 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions ISO epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of AGTR1 mRNA]]; epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of AGTR1 protein]]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of AGTR1 mRNA]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of AGTR1 protein] CTD PMID:36162953 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850
JBrowse link
G Ahcy S-adenosylhomocysteine hydrolase decreases expression EXP Warfarin results in decreased expression of AHCY mRNA CTD PMID:20493250 NCBI chr 2:154,901,230...154,916,417
Ensembl chr 2:154,901,230...154,916,417
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO 6-N,N-diethyl-beta,gamma-dibromomethylene-D-ATP inhibits the reaction [[Warfarin co-treated with Phosphates] results in decreased phosphorylation of AKT1 protein]; [Warfarin co-treated with Phosphates] results in decreased phosphorylation of AKT1 protein; [Warfarin co-treated with Vitamin K 1] results in decreased phosphorylation of AKT1 protein; Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased phosphorylation of AKT1 protein] CTD PMID:22659116 PMID:27212383 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Alb albumin multiple interactions
affects binding
decreases expression
ISO [Warfarin binds to ALB protein] inhibits the reaction [copper (II) diacetyl-di(N(4)-methylthiosemicarbazone) binds to ALB protein]; [Warfarin binds to ALB protein] inhibits the reaction [copper pyruvaldehyde bis(N(4)-methylthiosemicarbazone) complex binds to ALB protein]; Aspirin inhibits the reaction [Warfarin binds to ALB protein]; prodan inhibits the reaction [Warfarin binds to ALB protein]; Pyruvaldehyde inhibits the reaction [Warfarin binds to ALB protein]
Warfarin results in decreased expression of ALB protein
CTD PMID:10506189 PMID:12044178 PMID:18937368 PMID:19596536 PMID:20934417 More... NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein increases expression ISO Warfarin results in increased expression of ALOX5AP mRNA CTD PMID:16698924 NCBI chr 5:149,201,814...149,224,963
Ensembl chr 5:149,201,577...149,224,963
JBrowse link
G Alpl alkaline phosphatase, liver/bone/kidney multiple interactions EXP Warfarin inhibits the reaction [BMP2 protein results in increased activity of ALPL protein]; Warfarin inhibits the reaction [BMP2 protein results in increased expression of ALPL mRNA]; Warfarin inhibits the reaction [RUNX2 protein results in increased expression of ALPL mRNA] CTD PMID:21910061 NCBI chr 4:137,469,042...137,523,695
Ensembl chr 4:137,469,044...137,523,695
JBrowse link
G Anxa4 annexin A4 decreases expression EXP Warfarin results in decreased expression of ANXA4 mRNA CTD PMID:20493250 NCBI chr 6:86,713,822...86,770,616
Ensembl chr 6:86,713,822...86,770,566
JBrowse link
G Anxa5 annexin A5 decreases expression EXP Warfarin results in decreased expression of ANXA5 mRNA CTD PMID:20493250 NCBI chr 3:36,503,072...36,530,036
Ensembl chr 3:36,503,072...36,530,043
JBrowse link
G Apoa1 apolipoprotein A-I affects response to substance ISO APOA1 gene SNP affects the susceptibility to Warfarin CTD PMID:32282500 NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764
JBrowse link
G Apob apolipoprotein B affects response to substance ISO APOB gene SNP affects the susceptibility to Warfarin CTD PMID:31186542 NCBI chr12:8,027,629...8,066,839
Ensembl chr12:8,027,648...8,066,835
JBrowse link
G Apoe apolipoprotein E increases response to substance
affects response to substance
EXP
ISO
APOE gene mutant form results in increased susceptibility to Warfarin
APOE gene mutant form affects the susceptibility to Warfarin; APOE gene polymorphism affects the susceptibility to Warfarin; APOE gene SNP affects the susceptibility to Warfarin; APOE polymorphism affects the susceptibility to Warfarin; APOE protein affects the susceptibility to Warfarin; APOE SNP affects the susceptibility to Warfarin
CTD PMID:15952022 PMID:16847429 PMID:17048007 PMID:17325732 PMID:21228733 More... NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113
JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha increases expression EXP Warfarin results in increased expression of ARHGDIA mRNA CTD PMID:20493250 NCBI chr11:120,468,925...120,472,450
Ensembl chr11:120,468,930...120,472,450
JBrowse link
G Asph aspartate-beta-hydroxylase affects response to substance ISO ASPH gene SNP affects the susceptibility to Warfarin CTD PMID:27488176 NCBI chr 4:9,449,085...9,669,344
Ensembl chr 4:9,448,069...9,669,344
JBrowse link
G Axin2 axin 2 multiple interactions
increases expression
ISO [Warfarin co-treated with Vitamin K] results in increased expression of AXIN2 mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of AXIN2 mRNA]; Quercetin inhibits the reaction [Warfarin results in increased expression of AXIN2 mRNA] CTD PMID:23117658 NCBI chr11:108,808,687...108,841,609
Ensembl chr11:108,811,175...108,841,609
JBrowse link
G Axl AXL receptor tyrosine kinase multiple interactions
increases response to substance
decreases expression
decreases phosphorylation
ISO [Warfarin co-treated with Vitamin K 1] results in decreased expression of AXL protein; Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased expression of AXL protein]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of AXL protein]
AXL protein results in increased susceptibility to Warfarin
Warfarin results in decreased expression of AXL protein; Warfarin results in decreased expression of AXL protein modified form
Warfarin results in decreased phosphorylation of AXL protein
AXL protein promotes the reaction [Warfarin results in increased susceptibility to Gemcitabine]; Vitamin K inhibits the reaction [Warfarin results in decreased expression of AXL protein modified form]; Warfarin inhibits the reaction [GAS6 protein results in increased activity of AXL protein]
CTD PMID:15123721 PMID:26206560 PMID:27212383 NCBI chr 7:25,455,925...25,488,502
Ensembl chr 7:25,456,698...25,488,130
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO [Warfarin co-treated with Vitamin K 1] results in decreased expression of BCL2 protein; Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased expression of BCL2 protein] CTD PMID:27212383 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bglap bone gamma carboxyglutamate protein multiple interactions
increases expression
EXP
ISO
Warfarin inhibits the reaction [BMP2 protein results in increased activity of BGLAP protein]; Warfarin inhibits the reaction [BMP2 protein results in increased expression of BGLAP mRNA]; Warfarin inhibits the reaction [menaquinone 7 results in increased carboxylation of BGLAP protein]; Warfarin inhibits the reaction [menatetrenone results in increased carboxylation of BGLAP protein]; Warfarin inhibits the reaction [RUNX2 protein results in increased expression of BGLAP mRNA]; Warfarin inhibits the reaction [Vitamin K 1 results in increased carboxylation of BGLAP protein]
Warfarin results in increased expression of BGLAP mRNA; Warfarin results in increased expression of BGLAP protein modified form
[Warfarin co-treated with Vitamin K] results in increased expression of BGLAP mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of BGLAP mRNA]; Quercetin inhibits the reaction [Warfarin results in increased expression of BGLAP mRNA]; Warfarin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of BGLAP protein modified form]
CTD PMID:21910061 PMID:23117658 PMID:23223575 PMID:27488359 PMID:31173816 NCBI chr 3:88,290,802...88,291,773
Ensembl chr 3:88,290,808...88,291,771
JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions EXP
ISO
Warfarin inhibits the reaction [BMP2 protein results in increased activity of ALPL protein]; Warfarin inhibits the reaction [BMP2 protein results in increased activity of BGLAP protein]; Warfarin inhibits the reaction [BMP2 protein results in increased activity of RUNX2 protein]; Warfarin inhibits the reaction [BMP2 protein results in increased expression of ALPL mRNA]; Warfarin inhibits the reaction [BMP2 protein results in increased expression of BGLAP mRNA]; Warfarin inhibits the reaction [BMP2 protein results in increased expression of COL1A1 mRNA]; Warfarin inhibits the reaction [BMP2 protein results in increased expression of SP7 mRNA]
[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 mRNA; [Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 protein; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 mRNA]; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 protein]
CTD PMID:21910061 PMID:27412937 NCBI chr 2:133,394,079...133,404,816
Ensembl chr 2:133,394,079...133,404,805
JBrowse link
G C1qbp complement component 1, q subcomponent binding protein increases expression EXP Warfarin results in increased expression of C1QBP mRNA CTD PMID:20493250 NCBI chr11:70,868,672...70,873,852
Ensembl chr11:70,868,662...70,873,852
JBrowse link
G Calr calreticulin increases expression EXP Warfarin results in increased expression of CALR mRNA CTD PMID:20493250 NCBI chr 8:85,568,717...85,573,560
Ensembl chr 8:85,568,479...85,573,563
JBrowse link
G Calu calumenin decreases response to substance
affects response to substance
ISO CALU protein results in decreased susceptibility to Warfarin
CALU gene SNP affects the susceptibility to Warfarin; CALU polymorphism affects the susceptibility to Warfarin
CTD PMID:11641264 PMID:20200517 PMID:27632229 NCBI chr 6:29,348,105...29,376,674
Ensembl chr 6:29,348,068...29,377,109
JBrowse link
G Casp3 caspase 3 decreases expression
increases expression
multiple interactions
EXP
ISO
Warfarin results in decreased expression of CASP3 mRNA
Warfarin results in increased expression of CASP3 protein modified form
[Warfarin co-treated with Vitamin K 1] results in increased cleavage of CASP3 protein
Warfarin results in increased expression of CASP3 mRNA
CTD PMID:19815060 PMID:20493250 PMID:23990204 PMID:26206560 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Cat catalase increases activity ISO Warfarin results in increased activity of CAT protein CTD PMID:22342526 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions
ISO Warfarin results in increased expression of CCND1 mRNA
[Warfarin co-treated with Vitamin K] results in increased expression of CCND1 mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of CCND1 mRNA]; Quercetin inhibits the reaction [Warfarin results in increased expression of CCND1 mRNA]
CTD PMID:23117658 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Cct5 chaperonin containing TCP1 subunit 5 increases expression EXP Warfarin results in increased expression of CCT5 mRNA CTD PMID:20493250 NCBI chr15:31,590,946...31,601,992
Ensembl chr15:31,590,946...31,601,950
JBrowse link
G Cct6a chaperonin containing TCP1 subunit 6A increases expression EXP Warfarin results in increased expression of CCT6A mRNA CTD PMID:20493250 NCBI chr 5:129,864,420...129,875,284
Ensembl chr 5:129,864,062...129,875,212
JBrowse link
G Cct8 chaperonin containing TCP1 subunit 8 decreases expression EXP Warfarin results in decreased expression of CCT8 mRNA CTD PMID:20493250 NCBI chr16:87,280,213...87,292,757
Ensembl chr16:87,280,214...87,292,761
JBrowse link
G Cdc42 cell division cycle 42 decreases expression EXP Warfarin results in decreased expression of CDC42 mRNA CTD PMID:20493250 NCBI chr 4:137,047,011...137,085,007
Ensembl chr 4:137,047,007...137,085,031
JBrowse link
G Cdh1 cadherin 1 increases expression ISO Warfarin results in increased expression of CDH1 protein CTD PMID:26206560 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878
JBrowse link
G Clic1 chloride intracellular channel 1 decreases expression EXP Warfarin results in decreased expression of CLIC1 mRNA CTD PMID:20493250 NCBI chr17:35,269,219...35,277,695
Ensembl chr17:35,268,942...35,277,725
JBrowse link
G Cnn1 calponin 1 multiple interactions ISO [Warfarin co-treated with Vitamin K co-treated with Quercetin] results in increased expression of CNN1 mRNA CTD PMID:23117658 NCBI chr 9:22,010,501...22,020,517
Ensembl chr 9:22,010,512...22,020,926
JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions
increases expression
EXP
ISO
Warfarin inhibits the reaction [BMP2 protein results in increased expression of COL1A1 mRNA]
[Warfarin co-treated with Vitamin K] results in increased expression of COL1A1 mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of COL1A1 mRNA]; Quercetin inhibits the reaction [Warfarin results in increased expression of COL1A1 mRNA]
CTD PMID:21910061 PMID:23117658 PMID:23223575 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868
JBrowse link
G Cox15 cytochrome c oxidase assembly protein 15 affects response to substance ISO COX15 gene affects the susceptibility to Warfarin CTD PMID:28686080 NCBI chr19:43,721,693...43,741,439
Ensembl chr19:43,721,693...43,741,439
JBrowse link
G Cox5a cytochrome c oxidase subunit 5A increases expression EXP Warfarin results in increased expression of COX5A mRNA CTD PMID:20493250 NCBI chr 9:57,423,012...57,439,710
Ensembl chr 9:57,428,557...57,439,709
JBrowse link
G Crk v-crk avian sarcoma virus CT10 oncogene homolog increases expression EXP Warfarin results in increased expression of CRK mRNA CTD PMID:20493250 NCBI chr11:75,570,020...75,599,254
Ensembl chr11:75,570,085...75,597,734
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
affects response to substance
ISO Warfarin results in decreased expression of and affects the localization of CTNNB1 protein
CTNNB1 protein affects the susceptibility to Warfarin
Quercetin inhibits the reaction [Warfarin results in increased expression of and affects the localization of CTNNB1 protein]; Warfarin results in increased expression of and affects the localization of CTNNB1 protein
CTD PMID:23117658 PMID:23223575 PMID:26206560 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573
JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions ISO [Warfarin co-treated with lipopolysaccharide, E. coli O26-B6] results in decreased expression of CXCL8 mRNA CTD PMID:29594315 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity EXP Warfarin results in decreased activity of CYP1A1 protein CTD PMID:18420780 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing
affects response to substance
ISO CYP1A2 protein affects the metabolism of Warfarin
CYP1A2 SNP affects the susceptibility to Warfarin
CTD PMID:14676821 PMID:15280511 PMID:28079798 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
JBrowse link
G Cyp2a4 cytochrome P450, family 2, subfamily a, polypeptide 4 decreases activity EXP Warfarin results in decreased activity of CYP2A4 protein CTD PMID:18420780 NCBI chr 7:26,006,617...26,014,513
Ensembl chr 7:26,006,594...26,014,513
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 decreases activity EXP Warfarin results in decreased activity of CYP2B10 protein CTD PMID:18420780 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049
JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 decreases activity
affects response to substance
EXP
ISO
Warfarin results in decreased activity of CYP2C29 protein
CYP2C8 polymorphism affects the susceptibility to Warfarin
CTD PMID:18420780 PMID:34382722 NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157
JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 affects response to substance
affects metabolic processing
multiple interactions
ISO CYP2C19 gene polymorphism affects the susceptibility to Warfarin; CYP2C19 polymorphism affects the susceptibility to Warfarin; CYP2C19 protein affects the susceptibility to Warfarin
CYP2C19 protein affects the metabolism of Warfarin
CYP2C19 gene polymorphism affects the metabolism of and affects the susceptibility to Warfarin; Omeprazole affects the reaction [CYP2C19 protein affects the metabolism of Warfarin]
CTD PMID:18520598 PMID:19752777 PMID:25652102 PMID:27356304 NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519
JBrowse link
G Cyp2c52-ps cytochrome P450, family 2, subfamily c, polypeptide 52, pseudogene increases metabolic processing
affects response to substance
ISO CYP2C11 protein results in increased metabolism of Warfarin
CYP2C18 gene polymorphism affects the susceptibility to Warfarin; CYP2C18 protein affects the susceptibility to Warfarin
CTD PMID:19752777 PMID:30724651 NCBI chr19:38,965,106...38,992,071
Ensembl chr19:38,965,091...38,991,733
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 affects metabolic processing
increases hydroxylation
affects abundance
decreases activity
multiple interactions
increases metabolic processing
affects response to substance
increases hydrolysis
affects hydroxylation
decreases response to substance
decreases metabolic processing
decreases hydroxylation
increases response to substance
affects hydrolysis
ISO CYP2C9 enhancer polymorphism affects the metabolism of Warfarin; CYP2C9 gene affects the metabolism of Warfarin; CYP2C9 gene polymorphism affects the metabolism of Warfarin; CYP2C9 protein affects the metabolism of Warfarin
CYP2C9 protein results in increased hydroxylation of Warfarin
CYP2C9 gene polymorphism affects the abundance of Warfarin
Warfarin results in decreased activity of CYP2C9 protein
10-hydroxywarfarin inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin]; 4'-hydroxywarfarin inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin]; 6-hydroxywarfarin inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin]; 7-hydroxywarfarin inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 6-hydroxywarfarin]; 8-hydroxywarfarin inhibits the reaction [[CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin]; [[Ticrynafen results in decreased activity of CYP2C9 protein] which affects the metabolism of Warfarin analog] which affects the abundance of 7-hydroxywarfarin; [CYP2C9 gene polymorphism affects the metabolism of Warfarin] which affects the abundance of 10-hydroxywarfarin; [CYP2C9 gene polymorphism affects the metabolism of Warfarin] which affects the abundance of 4'-hydroxywarfarin; [CYP2C9 gene polymorphism affects the metabolism of Warfarin] which affects the abundance of 6-hydroxywarfarin; [CYP2C9 gene polymorphism affects the metabolism of Warfarin] which affects the abundance of 7-hydroxywarfarin; [CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 6-hydroxywarfarin; [CYP2C9 protein results in increased hydroxylation of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin; [CYP2C9 protein results in increased metabolism of Warfarin] which results in increased chemical synthesis of 6-hydroxywarfarin; [CYP2C9 protein results in increased metabolism of Warfarin] which results in increased chemical synthesis of 7-hydroxywarfarin; [Ticrynafen results in decreased activity of CYP2C9 protein] which affects the metabolism of Warfarin analog; [Warfarin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP2C9 mRNA; Benzbromarone inhibits the reaction [CYP2C9 protein affects the metabolism of Warfarin]; CYP2C9 gene polymorphism affects the reaction [Vitamin K affects the susceptibility to Warfarin]; CYP2C9 gene polymorphism affects the susceptibility to and affects the metabolism of Warfarin; Simvastatin affects the reaction [CYP2C9 polymorphism affects the susceptibility to Warfarin]; Warfarin inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]
CYP2C9 affects the susceptibility to Warfarin; CYP2C9 alternative form affects the susceptibility to Warfarin; CYP2C9 gene affects the susceptibility to Warfarin; CYP2C9 gene mutant form affects the susceptibility to Warfarin; CYP2C9 gene polymorphism affects the susceptibility to Warfarin; CYP2C9 gene SNP affects the susceptibility to Warfarin; CYP2C9 polymorphism affects the susceptibility to Warfarin; CYP2C9 protein affects the susceptibility to Warfarin; CYP2C9 protein polymorphism affects the susceptibility to Warfarin; CYP2C9 SNP affects the susceptibility to Warfarin; CYP2C9 SNP affects the susceptibility to Warfarin analog
CYP2C9 protein results in increased hydrolysis of Warfarin
CYP2C9 protein affects the hydroxylation of Warfarin
CYP2C9 gene polymorphism results in decreased susceptibility to Warfarin
CYP2C9 gene polymorphism results in decreased metabolism of Warfarin
CYP2C9 gene polymorphism results in decreased hydroxylation of Warfarin
CYP2C9 gene mutant form results in increased susceptibility to Warfarin; CYP2C9 gene polymorphism results in increased susceptibility to Warfarin; CYP2C9 protein results in increased susceptibility to Warfarin; CYP2C9 results in increased susceptibility to Warfarin
CYP2C9 gene polymorphism affects the hydrolysis of Warfarin
CTD PMID:9241660 PMID:9522436 PMID:9698079 PMID:10613612 PMID:11127854 More... NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388
JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 decreases activity ISO Warfarin results in decreased activity of CYP2D6 protein CTD PMID:18420780 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461
JBrowse link
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 affects response to substance ISO CYP3A5 gene polymorphism affects the susceptibility to Warfarin; CYP3A5 polymorphism affects the susceptibility to Warfarin; CYP3A5 protein affects the susceptibility to Warfarin CTD PMID:19752777 PMID:34382722 NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881
JBrowse link
G Dctn2 dynactin 2 decreases expression EXP Warfarin results in decreased expression of DCTN2 mRNA CTD PMID:20493250 NCBI chr10:127,102,131...127,117,828
Ensembl chr10:127,102,237...127,117,819
JBrowse link
G Ddhd1 DDHD domain containing 1 affects response to substance ISO DDHD1 gene SNP affects the susceptibility to Warfarin CTD PMID:27488176 NCBI chr14:45,830,628...45,895,600
Ensembl chr14:45,825,924...45,895,600
JBrowse link
G Ddt D-dopachrome tautomerase decreases expression EXP Warfarin results in decreased expression of DDT mRNA CTD PMID:20493250 NCBI chr10:75,607,067...75,609,208
Ensembl chr10:75,607,064...75,609,248
JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase decreases expression EXP Warfarin results in decreased expression of DLST mRNA CTD PMID:20493250 NCBI chr12:85,157,597...85,180,865
Ensembl chr12:85,157,607...85,181,619
JBrowse link
G Dock7 dedicator of cytokinesis 7 increases expression EXP Warfarin results in increased expression of DOCK7 mRNA CTD PMID:20493250 NCBI chr 4:98,824,669...99,019,190
Ensembl chr 4:98,824,908...99,009,152
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 increases expression EXP Warfarin results in increased expression of DPYSL2 mRNA CTD PMID:20493250 NCBI chr14:67,040,313...67,148,490
Ensembl chr14:67,040,313...67,106,137
JBrowse link
G Dstn destrin decreases expression EXP Warfarin results in decreased expression of DSTN mRNA CTD PMID:20493250 NCBI chr 2:143,757,251...143,785,244
Ensembl chr 2:143,757,240...143,785,244
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 decreases expression EXP Warfarin results in decreased expression of EEF2 mRNA CTD PMID:20493250 NCBI chr10:81,012,465...81,018,343
Ensembl chr10:81,012,465...81,018,332
JBrowse link
G Eif3i eukaryotic translation initiation factor 3, subunit I decreases expression EXP Warfarin results in decreased expression of EIF3I mRNA CTD PMID:20493250 NCBI chr 4:129,485,767...129,494,441
Ensembl chr 4:129,485,753...129,494,441
JBrowse link
G Emcn endomucin decreases expression ISO Warfarin results in decreased expression of EMCN protein CTD PMID:26206560 NCBI chr 3:137,046,824...137,136,830
Ensembl chr 3:137,046,828...137,137,946
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 increases expression ISO Warfarin results in increased expression of ENPP1 mRNA; Warfarin results in increased expression of ENPP1 protein CTD PMID:22659116 NCBI chr10:24,513,812...24,588,057
Ensembl chr10:24,513,812...24,588,057
JBrowse link
G Epha7 Eph receptor A7 affects response to substance ISO EPHA7 promoter SNP affects the susceptibility to Warfarin CTD PMID:30357299 NCBI chr 4:28,811,840...28,969,391
Ensembl chr 4:28,813,131...28,967,499
JBrowse link
G Ephx1 epoxide hydrolase 1, microsomal increases response to substance
affects response to substance
ISO EPHX1 protein results in increased susceptibility to Warfarin
EPHX1 gene polymorphism affects the susceptibility to Warfarin; EPHX1 gene SNP affects the susceptibility to Warfarin; EPHX1 intron SNP affects the susceptibility to Warfarin; EPHX1 polymorphism affects the susceptibility to Warfarin; EPHX1 SNP affects the susceptibility to Warfarin
CTD PMID:15900282 PMID:17496169 PMID:20842355 PMID:21192345 PMID:24092646 More... NCBI chr 1:180,817,121...180,845,134
Ensembl chr 1:180,803,775...180,848,469
JBrowse link
G Erp29 endoplasmic reticulum protein 29 decreases expression EXP Warfarin results in decreased expression of ERP29 mRNA CTD PMID:20493250 NCBI chr 5:121,582,816...121,590,537
Ensembl chr 5:121,566,653...121,590,569
JBrowse link
G F10 coagulation factor X decreases activity ISO Warfarin results in decreased activity of F10 protein CTD PMID:3490277 PMID:20371969 NCBI chr 8:13,087,308...13,106,676
Ensembl chr 8:13,087,308...13,106,676
JBrowse link
G F2 coagulation factor II multiple interactions
decreases activity
decreases expression
affects response to substance
ISO Fenofibrate promotes the reaction [Warfarin results in decreased expression of F2 protein]
Warfarin results in decreased activity of F2 protein
F2 gene polymorphism affects the susceptibility to Warfarin
CTD PMID:3490277 PMID:9681093 PMID:14656880 NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759
JBrowse link
G F5 coagulation factor V affects response to substance
decreases activity
ISO F5 gene polymorphism affects the susceptibility to Warfarin; F5 protein affects the susceptibility to Warfarin
Warfarin results in decreased activity of F5 protein
CTD PMID:3490277 PMID:19752777 NCBI chr 1:163,979,396...164,048,539
Ensembl chr 1:163,979,407...164,047,846
JBrowse link
G F7 coagulation factor VII affects response to substance
decreases activity
multiple interactions
decreases expression
ISO F7 gene mutant form affects the susceptibility to Warfarin; F7 gene polymorphism affects the susceptibility to Warfarin
Warfarin results in decreased activity of F7 protein
Fenofibrate promotes the reaction [Warfarin results in decreased expression of F7 protein]
CTD PMID:3490277 PMID:9681093 PMID:14656880 PMID:20371969 PMID:20885134 NCBI chr 8:13,075,499...13,085,809
Ensembl chr 8:13,076,034...13,085,809
JBrowse link
G F9 coagulation factor IX decreases activity
increases response to substance
ISO Warfarin results in decreased activity of F9 protein
F9 gene alternative form results in increased susceptibility to Warfarin
CTD PMID:3490277 PMID:29450643 NCBI chr  X:59,044,675...59,076,120
Ensembl chr  X:59,044,824...59,076,119
JBrowse link
G Fabp1 fatty acid binding protein 1, liver multiple interactions ISO Warfarin inhibits the reaction [3-(p-azidobenzyl)-4-hydroxycoumarin binds to Fabp1 protein] RGD PMID:1939124 RGD:1626448 NCBI chr 6:71,176,863...71,182,018
Ensembl chr 6:71,176,811...71,182,007
JBrowse link
G Fgf5 fibroblast growth factor 5 affects response to substance ISO FGF5 gene affects the susceptibility to Warfarin CTD PMID:28686080 NCBI chr 5:98,402,108...98,424,892
Ensembl chr 5:98,402,043...98,424,889
JBrowse link
G Fpgs folylpolyglutamyl synthetase affects response to substance ISO FPGS gene polymorphism affects the susceptibility to Warfarin CTD PMID:25079360 NCBI chr 2:32,572,621...32,594,163
Ensembl chr 2:32,572,621...32,594,157
JBrowse link
G Fscn1 fascin actin-bundling protein 1 decreases expression EXP Warfarin results in decreased expression of FSCN1 mRNA CTD PMID:20493250 NCBI chr 5:142,946,110...142,958,944
Ensembl chr 5:142,946,098...142,958,940
JBrowse link
G G3bp1 G3BP stress granule assembly factor 1 increases expression EXP Warfarin results in increased expression of G3BP1 mRNA CTD PMID:20493250 NCBI chr11:55,360,521...55,391,722
Ensembl chr11:55,360,511...55,395,664
JBrowse link
G Gal3st1 galactose-3-O-sulfotransferase 1 increases expression EXP Warfarin results in increased expression of GAL3ST1 mRNA CTD PMID:27397090 NCBI chr11:3,933,636...3,949,328
Ensembl chr11:3,933,636...3,949,326
JBrowse link
G Gale galactose-4-epimerase, UDP decreases expression EXP Warfarin results in decreased expression of GALE mRNA CTD PMID:20493250 NCBI chr 4:135,690,550...135,695,489
Ensembl chr 4:135,691,038...135,695,489
JBrowse link
G Gas6 growth arrest specific 6 decreases expression
decreases carboxylation
multiple interactions
ISO Warfarin results in decreased expression of GAS6 protein
Warfarin results in decreased carboxylation of GAS6 protein
Warfarin inhibits the reaction [GAS6 protein results in increased activity of AXL protein]
[Warfarin co-treated with Vitamin K 1] results in decreased expression of GAS6 protein; Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased expression of GAS6 protein]; Warfarin results in decreased activity of and results in decreased carboxylation of GAS6 protein
CTD PMID:9163328 PMID:19564549 PMID:26206560 PMID:27212383 NCBI chr 8:13,515,374...13,544,535
Ensembl chr 8:13,515,374...13,544,490
JBrowse link
G Gata4 GATA binding protein 4 affects response to substance ISO GATA4 gene SNP affects the susceptibility to Warfarin CTD PMID:31190750 NCBI chr14:63,436,363...63,509,161
Ensembl chr14:63,436,371...63,509,141
JBrowse link
G Gata6 GATA binding protein 6 affects response to substance ISO GATA6 gene SNP affects the susceptibility to Warfarin CTD PMID:31190750 NCBI chr18:11,052,510...11,085,636
Ensembl chr18:11,052,064...11,085,635
JBrowse link
G Gdi2 GDP dissociation inhibitor 2 increases expression EXP Warfarin results in increased expression of GDI2 mRNA CTD PMID:20493250 NCBI chr13:3,588,075...3,616,261
Ensembl chr13:3,588,063...3,617,871
JBrowse link
G Gfap glial fibrillary acidic protein increases expression EXP Warfarin results in increased expression of GFAP mRNA; Warfarin results in increased expression of GFAP protein CTD PMID:27397090 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738
JBrowse link
G Ggcx gamma-glutamyl carboxylase affects response to substance
increases activity
increases response to substance
decreases response to substance
ISO GGCX gene polymorphism affects the susceptibility to Warfarin; GGCX gene SNP affects the susceptibility to Warfarin; GGCX polymorphism affects the susceptibility to Warfarin
Warfarin results in increased activity of GGCX protein
GGCX protein results in increased susceptibility to Warfarin
GGCX gene polymorphism results in decreased susceptibility to Warfarin
CTD PMID:3490277 PMID:16676068 PMID:17049586 PMID:17496169 PMID:17764537 More... NCBI chr 6:72,391,262...72,407,696
Ensembl chr 6:72,391,291...72,407,695
JBrowse link
G Gmps guanine monophosphate synthetase increases expression EXP Warfarin results in increased expression of GMPS mRNA CTD PMID:20493250 NCBI chr 3:63,871,054...63,928,975
Ensembl chr 3:63,883,527...63,930,000
JBrowse link
G Gprc6a G protein-coupled receptor, family C, group 6, member A multiple interactions ISO Warfarin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of GPRC6A mRNA] CTD PMID:27488359 NCBI chr10:51,490,919...51,507,554
Ensembl chr10:51,490,919...51,507,557
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO [Warfarin co-treated with Vitamin K] results in increased phosphorylation of GSK3B protein; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased phosphorylation of GSK3B protein] CTD PMID:23117658 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446
JBrowse link
G Hdac1 histone deacetylase 1 increases expression EXP Warfarin results in increased expression of HDAC1 mRNA CTD PMID:20493250 NCBI chr 4:129,409,897...129,436,516
Ensembl chr 4:129,409,897...129,436,506
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions ISO epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of HIF1A protein]]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of HIF1A protein] CTD PMID:36162953 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304
JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 increases expression EXP Warfarin results in increased expression of HINT1 mRNA CTD PMID:20493250 NCBI chr11:54,757,209...54,761,332
Ensembl chr11:54,757,209...54,761,327
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase multiple interactions ISO Warfarin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of HMGCR mRNA] CTD PMID:27488359 NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444
JBrowse link
G Hmox1 heme oxygenase 1 affects expression ISO Warfarin affects the expression of HMOX1 mRNA CTD PMID:22954530 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Hnrnpab heterogeneous nuclear ribonucleoprotein A/B increases expression EXP Warfarin results in increased expression of HNRNPAB mRNA CTD PMID:20493250 NCBI chr11:51,490,927...51,497,708
Ensembl chr11:51,490,927...51,497,674
JBrowse link
G Hnrnpdl heterogeneous nuclear ribonucleoprotein D-like decreases expression EXP Warfarin results in decreased expression of HNRNPDL mRNA CTD PMID:20493250 NCBI chr 5:100,181,436...100,187,769
Ensembl chr 5:100,181,436...100,187,523
JBrowse link
G Hnrnpf heterogeneous nuclear ribonucleoprotein F increases expression EXP Warfarin results in increased expression of HNRNPF mRNA CTD PMID:20493250 NCBI chr 6:117,877,301...117,902,583
Ensembl chr 6:117,877,285...117,902,583
JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K increases expression
decreases expression
EXP Warfarin results in increased expression of HNRNPK mRNA
Warfarin results in decreased expression of HNRNPK mRNA
CTD PMID:20493250 NCBI chr13:58,538,946...58,551,157
Ensembl chr13:58,538,956...58,551,157
JBrowse link
G Hp haptoglobin increases expression ISO Warfarin results in increased expression of HP protein CTD PMID:22342526 NCBI chr 8:110,301,760...110,305,804
Ensembl chr 8:110,301,760...110,305,804
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 decreases expression EXP Warfarin results in decreased expression of HSP90AB1 mRNA CTD PMID:20493250 NCBI chr17:45,878,704...45,884,187
Ensembl chr17:45,878,701...45,884,197
JBrowse link
G Hspa8 heat shock protein 8 increases expression EXP Warfarin results in increased expression of HSPA8 mRNA CTD PMID:20493250 NCBI chr 9:40,712,572...40,716,498
Ensembl chr 9:40,712,280...40,721,383
JBrowse link
G Hspd1 heat shock protein 1 (chaperonin) increases expression EXP Warfarin results in increased expression of HSPD1 mRNA CTD PMID:20493250 NCBI chr 1:55,116,992...55,127,402
Ensembl chr 1:55,116,994...55,127,402
JBrowse link
G Il12a interleukin 12a increases expression ISO Warfarin results in increased expression of IL12A mRNA CTD PMID:22342526 NCBI chr 3:68,597,977...68,605,881
Ensembl chr 3:68,597,977...68,605,880
JBrowse link
G Il12b interleukin 12b increases expression ISO Warfarin results in increased expression of IL12B mRNA CTD PMID:22342526 NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO Warfarin inhibits the reaction [Vitamin K 2 results in decreased susceptibility to IL1B protein]
Warfarin results in decreased expression of IL1B mRNA
[Warfarin co-treated with Vitamin K] results in increased expression of IL1B mRNA
CTD PMID:20460758 PMID:23117658 PMID:29594315 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Warfarin co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
decreases expression
decreases secretion
ISO
EXP
Warfarin results in increased expression of IL6 protein
[Warfarin co-treated with Vitamin K] results in increased expression of IL6 mRNA
Warfarin results in decreased expression of IL6 mRNA
Warfarin results in decreased secretion of IL6 protein
Warfarin results in decreased expression of IL6 protein
CTD PMID:18772604 PMID:22342526 PMID:23117658 PMID:26742017 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Ins1 insulin I multiple interactions
increases secretion
ISO Warfarin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased secretion of INS1 protein]
Warfarin results in increased secretion of INS1 protein
CTD PMID:27488359 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914
JBrowse link
G Ipo5 importin 5 decreases expression EXP Warfarin results in decreased expression of IPO5 mRNA CTD PMID:20493250 NCBI chr14:121,134,271...121,185,451
Ensembl chr14:121,148,636...121,185,411
JBrowse link
G Isyna1 myo-inositol 1-phosphate synthase A1 increases expression EXP Warfarin results in increased expression of ISYNA1 mRNA CTD PMID:20493250 NCBI chr 8:71,047,131...71,049,940
Ensembl chr 8:71,047,023...71,049,940
JBrowse link
G Krt18 keratin 18 decreases expression EXP Warfarin results in decreased expression of KRT18 mRNA CTD PMID:20493250 NCBI chr15:101,936,651...101,940,461
Ensembl chr15:101,936,615...101,940,462
JBrowse link
G Lasp1 LIM and SH3 protein 1 decreases expression EXP Warfarin results in decreased expression of LASP1 mRNA CTD PMID:20493250 NCBI chr11:97,689,748...97,729,591
Ensembl chr11:97,689,826...97,729,590
JBrowse link
G Lrp1 low density lipoprotein receptor-related protein 1 affects response to substance ISO LRP1 gene SNP affects the susceptibility to Warfarin CTD PMID:32282500 NCBI chr10:127,374,026...127,457,158
Ensembl chr10:127,374,030...127,457,017
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein] CTD PMID:36162953 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein] CTD PMID:36162953 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mgp matrix Gla protein multiple interactions
decreases carboxylation
EXP
ISO
[[Warfarin co-treated with Vitamin K 1] results in decreased carboxylation of MGP protein] which results in decreased activity of MGP protein; [Warfarin co-treated with Vitamin K 1] results in decreased activity of MGP protein; [Warfarin co-treated with Vitamin K 1] results in decreased carboxylation of MGP protein; [Warfarin co-treated with Vitamin K 1] results in decreased expression of MGP mRNA
Warfarin results in decreased carboxylation of MGP protein
[Quercetin co-treated with Warfarin] results in decreased carboxylation of MGP protein; [Vitamin K co-treated with Warfarin] results in increased carboxylation of MGP protein; Warfarin inhibits the reaction [Vitamin K 1 results in increased expression of and results in increased secretion of MGP protein modified form]; Warfarin results in decreased expression of and results in decreased secretion of MGP protein; Warfarin results in decreased expression of and results in decreased secretion of MGP protein modified form
CTD PMID:21705322 PMID:23223575 PMID:23990204 NCBI chr 6:136,849,433...136,852,821
Ensembl chr 6:136,849,433...136,852,821
JBrowse link
G Mir133a-2 microRNA 133a-2 affects response to substance ISO MIR133A2 gene SNP affects the susceptibility to Warfarin CTD PMID:26113018 NCBI chr 2:180,040,172...180,040,275
Ensembl chr 2:180,040,172...180,040,275
JBrowse link
G Mpo myeloperoxidase increases activity ISO Warfarin results in increased activity of MPO protein CTD PMID:26742017 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
JBrowse link
G Myh1 myosin, heavy polypeptide 1, skeletal muscle, adult multiple interactions ISO [Warfarin co-treated with Vitamin K co-treated with Quercetin] results in increased expression of MYH1 mRNA CTD PMID:23117658 NCBI chr11:67,090,922...67,115,401
Ensembl chr11:67,090,878...67,115,401
JBrowse link
G Myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha affects response to substance ISO MYH6 polymorphism affects the susceptibility to Warfarin CTD PMID:34515533 NCBI chr14:55,179,378...55,205,553
Ensembl chr14:55,179,378...55,204,384
JBrowse link
G Nedd4 neural precursor cell expressed, developmentally down-regulated 4 affects response to substance ISO NEDD4 gene SNP affects the susceptibility to Warfarin CTD PMID:27488176 NCBI chr 9:72,569,613...72,657,133
Ensembl chr 9:72,569,628...72,657,134
JBrowse link
G Nmral1 NmrA-like family domain containing 1 increases expression EXP Warfarin results in increased expression of NMRAL1 mRNA CTD PMID:20493250 NCBI chr16:4,529,181...4,537,220
Ensembl chr16:4,527,923...4,537,220
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 affects response to substance ISO NQO1 gene SNP affects the susceptibility to Warfarin; NQO1 polymorphism affects the susceptibility to Warfarin CTD PMID:23215885 PMID:26257249 PMID:27581200 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
decreases expression
ISO [Warfarin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP2C9 mRNA; [Warfarin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; Warfarin binds to and results in increased activity of NR1I2 protein
Warfarin results in decreased expression of NR1I2 mRNA
CTD PMID:20735727 PMID:30963258 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186
JBrowse link
G Nucb1 nucleobindin 1 increases expression EXP Warfarin results in increased expression of NUCB1 mRNA CTD PMID:20493250 NCBI chr 7:45,142,300...45,159,813
Ensembl chr 7:45,139,882...45,159,830
JBrowse link
G Numb NUMB endocytic adaptor protein multiple interactions ISO [Warfarin co-treated with Vitamin K] results in increased expression of NUMB mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of NUMB mRNA] CTD PMID:23117658 NCBI chr12:83,840,808...83,968,708
Ensembl chr12:83,840,808...83,968,708
JBrowse link
G Oat ornithine aminotransferase decreases expression EXP Warfarin results in decreased expression of OAT mRNA CTD PMID:20493250 NCBI chr 7:132,159,204...132,178,127
Ensembl chr 7:132,159,207...132,178,127
JBrowse link
G Orm1 orosomucoid 1 multiple interactions
affects binding
increases response to substance
affects response to substance
ISO Chlorpromazine inhibits the reaction [Warfarin binds to ORM1 protein alternative form]; Dipyridamole inhibits the reaction [Warfarin binds to ORM1 protein alternative form]; Lidocaine inhibits the reaction [Warfarin binds to ORM1 protein alternative form]; Progesterone inhibits the reaction [Warfarin binds to ORM1 protein alternative form]
ORM1 protein results in increased susceptibility to Warfarin
ORM1 gene polymorphism affects the susceptibility to Warfarin; ORM1 polymorphism affects the susceptibility to Warfarin
CTD PMID:8946472 PMID:17496169 PMID:23208322 PMID:26644206 NCBI chr 4:63,262,793...63,266,400
Ensembl chr 4:63,262,797...63,266,400
JBrowse link
G Pa2g4 proliferation-associated 2G4 increases expression EXP Warfarin results in increased expression of PA2G4 mRNA CTD PMID:20493250 NCBI chr10:128,393,635...128,401,803
Ensembl chr10:128,393,635...128,401,856
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases expression ISO Warfarin results in increased expression of PARP1 protein modified form CTD PMID:26206560 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Pdgfb platelet derived growth factor, B polypeptide decreases expression ISO Warfarin results in decreased expression of PDGFB mRNA; Warfarin results in decreased expression of PDGFB protein CTD PMID:11290560 NCBI chr15:79,880,066...79,899,178
Ensembl chr15:79,880,075...79,899,178
JBrowse link
G Pdia3 protein disulfide isomerase associated 3 increases expression
decreases expression
EXP Warfarin results in increased expression of PDIA3 mRNA
Warfarin results in decreased expression of PDIA3 mRNA
CTD PMID:20493250 NCBI chr 2:121,244,383...121,269,168
Ensembl chr 2:121,244,256...121,269,168
JBrowse link
G Pdia4 protein disulfide isomerase associated 4 decreases expression EXP Warfarin results in decreased expression of PDIA4 mRNA CTD PMID:20493250 NCBI chr 6:47,773,075...47,790,446
Ensembl chr 6:47,773,075...47,790,364
JBrowse link
G Pgam1 phosphoglycerate mutase 1 decreases expression
increases expression
EXP Warfarin results in decreased expression of PGAM1 mRNA
Warfarin results in increased expression of PGAM1 mRNA
CTD PMID:20493250 NCBI chr19:41,900,310...41,907,104
Ensembl chr19:41,900,362...41,907,099
JBrowse link
G Pkm pyruvate kinase, muscle decreases expression EXP Warfarin results in decreased expression of PKM mRNA CTD PMID:20493250 NCBI chr 9:59,563,859...59,586,655
Ensembl chr 9:59,563,651...59,586,658
JBrowse link
G Plp1 proteolipid protein (myelin) 1 increases expression EXP Warfarin results in increased expression of PLP1 mRNA CTD PMID:27397090 NCBI chr  X:135,720,897...135,739,331
Ensembl chr  X:135,723,420...135,740,482
JBrowse link
G Por cytochrome p450 oxidoreductase affects response to substance ISO POR gene SNP affects the susceptibility to Warfarin CTD PMID:27488389 NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180
JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha decreases expression EXP Warfarin results in decreased expression of PPP1CA mRNA CTD PMID:20493250 NCBI chr19:4,242,173...4,245,418
Ensembl chr19:4,242,064...4,245,419
JBrowse link
G Ppp2r1a protein phosphatase 2, regulatory subunit A, alpha increases expression EXP Warfarin results in increased expression of PPP2R1A mRNA CTD PMID:20493250 NCBI chr17:21,165,716...21,186,167
Ensembl chr17:21,165,573...21,186,178
JBrowse link
G Proc protein C increases response to substance
affects response to substance
ISO PROC protein results in increased susceptibility to Warfarin
PROC gene polymorphism affects the susceptibility to Warfarin
CTD PMID:17048007 PMID:17496169 NCBI chr18:32,256,179...32,272,623
Ensembl chr18:32,256,179...32,272,623
JBrowse link
G Pros1 protein S (alpha) affects response to substance ISO PROS1 gene polymorphism affects the susceptibility to Warfarin; PROS1 protein affects the susceptibility to Warfarin CTD PMID:19752777 NCBI chr16:62,674,670...62,749,709
Ensembl chr16:62,674,670...62,749,709
JBrowse link
G Prss53 serine protease 53 affects response to substance ISO PRSS53 gene SNP affects the susceptibility to Warfarin CTD PMID:21590310 NCBI chr 7:127,484,616...127,490,594
Ensembl chr 7:127,485,013...127,490,142
JBrowse link
G Psma3 proteasome subunit alpha 3 decreases expression EXP Warfarin results in decreased expression of PSMA3 mRNA CTD PMID:20493250 NCBI chr12:71,016,082...71,042,651
Ensembl chr12:71,021,395...71,043,121
JBrowse link
G Psma6 proteasome subunit alpha 6 decreases expression EXP Warfarin results in decreased expression of PSMA6 mRNA CTD PMID:20493250 NCBI chr12:55,431,007...55,465,244
Ensembl chr12:55,431,007...55,465,239
JBrowse link
G Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 decreases expression EXP Warfarin results in decreased expression of PSMC2 mRNA CTD PMID:20493250 NCBI chr 5:21,990,273...22,008,785
Ensembl chr 5:21,990,281...22,008,785
JBrowse link
G Pth parathyroid hormone decreases activity EXP Warfarin results in decreased activity of PTH protein CTD PMID:11564701 NCBI chr 7:112,984,783...112,987,879
Ensembl chr 7:112,984,787...112,987,777
JBrowse link
G Rab1a RAB1A, member RAS oncogene family decreases expression EXP Warfarin results in decreased expression of RAB1A mRNA CTD PMID:20493250 NCBI chr11:20,151,412...20,176,856
Ensembl chr11:20,151,432...20,176,856
JBrowse link
G Rhoa ras homolog family member A decreases expression EXP Warfarin results in decreased expression of RHOA mRNA CTD PMID:20493250 NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133
JBrowse link
G Rpl27 ribosomal protein L27 increases expression EXP Warfarin results in increased expression of RPL27 mRNA CTD PMID:20493250 NCBI chr11:101,333,071...101,336,422
Ensembl chr11:101,333,124...101,336,355
JBrowse link
G Rpl9 ribosomal protein L9 increases expression EXP Warfarin results in increased expression of RPL9 mRNA CTD PMID:20493250 NCBI chr 5:65,545,707...65,548,774
Ensembl chr 5:65,545,707...65,548,787
JBrowse link
G Rplp0 ribosomal protein lateral stalk subunit P0 increases expression EXP Warfarin results in increased expression of RPLP0 mRNA CTD PMID:20493250 NCBI chr 5:115,697,526...115,701,788
Ensembl chr 5:115,697,526...115,701,786
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 multiple interactions ISO epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of RPS6KB1 protein]]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of RPS6KB1 protein] CTD PMID:36162953 NCBI chr11:86,389,695...86,435,711
Ensembl chr11:86,389,697...86,435,631
JBrowse link
G Rpsa ribosomal protein SA increases expression EXP Warfarin results in increased expression of RPSA mRNA CTD PMID:20493250 NCBI chr 9:119,956,832...119,961,435
Ensembl chr 9:119,956,755...119,961,435
JBrowse link
G Runx1 runt related transcription factor 1 multiple interactions
increases expression
ISO Quercetin inhibits the reaction [Warfarin results in increased expression of RUNX1 mRNA] CTD PMID:23223575 NCBI chr16:92,398,354...92,622,962
Ensembl chr16:92,398,354...92,623,037
JBrowse link
G Runx2 runt related transcription factor 2 multiple interactions EXP
ISO
Warfarin inhibits the reaction [BMP2 protein results in increased activity of RUNX2 protein]; Warfarin inhibits the reaction [RUNX2 protein results in increased expression of ALPL mRNA]; Warfarin inhibits the reaction [RUNX2 protein results in increased expression of BGLAP mRNA]
[Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 mRNA; [Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 protein; [Warfarin co-treated with Vitamin K] results in increased expression of RUNX2 mRNA; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 mRNA]; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 protein]; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of RUNX2 mRNA]
CTD PMID:21910061 PMID:23117658 PMID:27412937 NCBI chr17:44,806,873...45,125,518
Ensembl chr17:44,806,874...45,125,684
JBrowse link
G Ruvbl2 RuvB-like AAA ATPase 2 decreases expression EXP Warfarin results in decreased expression of RUVBL2 mRNA CTD PMID:20493250 NCBI chr 7:45,071,320...45,084,817
Ensembl chr 7:45,071,184...45,087,520
JBrowse link
G Sae1 SUMO1 activating enzyme subunit 1 decreases expression EXP Warfarin results in decreased expression of SAE1 mRNA CTD PMID:20493250 NCBI chr 7:16,054,161...16,121,821
Ensembl chr 7:16,054,159...16,121,731
JBrowse link
G Sephs1 selenophosphate synthetase 1 increases expression EXP Warfarin results in increased expression of SEPHS1 mRNA CTD PMID:20493250 NCBI chr 2:4,886,375...4,915,368
Ensembl chr 2:4,886,375...4,915,368
JBrowse link
G Serpinc1 serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 increases expression ISO Warfarin results in increased expression of SERPINC1 protein CTD PMID:73932 NCBI chr 1:160,806,153...160,830,113
Ensembl chr 1:160,806,155...160,833,433
JBrowse link
G Slc15a2 solute carrier family 15 (H+/peptide transporter), member 2 affects response to substance ISO SLC15A2 gene SNP affects the susceptibility to Warfarin CTD PMID:29234073 NCBI chr16:36,570,523...36,605,506
Ensembl chr16:36,570,539...36,605,324
JBrowse link
G Slco1b2 solute carrier organic anion transporter family, member 1b2 affects response to substance ISO SLCO1B3 gene SNP affects the susceptibility to Warfarin CTD PMID:29234073 NCBI chr 6:141,575,178...141,632,372
Ensembl chr 6:141,575,244...141,632,372
JBrowse link
G Sost sclerostin affects response to substance EXP SOST affects the susceptibility to Warfarin CTD PMID:35038187 NCBI chr11:101,853,284...101,857,841
Ensembl chr11:101,853,284...101,857,841
JBrowse link
G Sox5 SRY (sex determining region Y)-box 5 affects localization
decreases expression
EXP Warfarin affects the localization of SOX5 protein
Warfarin results in decreased expression of SOX5 mRNA; Warfarin results in decreased expression of SOX5 protein
CTD PMID:34520801 NCBI chr 6:143,774,151...144,728,008
Ensembl chr 6:143,774,151...144,727,703
JBrowse link
G Sox9 SRY (sex determining region Y)-box 9 affects localization
multiple interactions
EXP Warfarin affects the localization of SOX9 protein
leptomycin B inhibits the reaction [Warfarin affects the localization of SOX9 protein]
CTD PMID:34520801 NCBI chr11:112,673,036...112,678,583
Ensembl chr11:112,673,050...112,678,586
JBrowse link
G Sp7 Sp7 transcription factor 7 multiple interactions EXP Warfarin inhibits the reaction [BMP2 protein results in increased expression of SP7 mRNA] CTD PMID:21910061 NCBI chr15:102,265,038...102,275,498
Ensembl chr15:102,265,041...102,275,617
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP
ISO
[Warfarin co-treated with Vitamin K 1] results in increased expression of SPP1 mRNA
[Quercetin co-treated with Warfarin] results in increased expression of SPP1 mRNA; [Warfarin co-treated with Vitamin K] results in increased expression of SPP1 mRNA
CTD PMID:23117658 PMID:23223575 PMID:23990204 NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916
JBrowse link
G Stip1 stress-induced phosphoprotein 1 decreases expression EXP Warfarin results in decreased expression of STIP1 mRNA CTD PMID:20493250 NCBI chr19:6,998,064...7,017,394
Ensembl chr19:6,998,070...7,017,335
JBrowse link
G Tagln transgelin multiple interactions EXP
ISO
[Warfarin co-treated with Vitamin K 1] results in decreased expression of TAGLN mRNA
[Warfarin co-treated with Vitamin K co-treated with Quercetin] results in increased expression of TAGLN mRNA
CTD PMID:23117658 PMID:23990204 NCBI chr 9:45,840,926...45,847,356
Ensembl chr 9:45,840,917...45,847,356
JBrowse link
G Tcf4 transcription factor 4 multiple interactions
increases expression
ISO [Warfarin co-treated with Vitamin K] results in increased expression of TCF4 mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of TCF4 mRNA]; Quercetin inhibits the reaction [Warfarin results in increased expression of TCF4 mRNA] CTD PMID:23117658 NCBI chr18:69,476,500...69,821,038
Ensembl chr18:69,476,427...69,822,150
JBrowse link
G Tcp1 t-complex protein 1 increases expression EXP Warfarin results in increased expression of TCP1 mRNA CTD PMID:20493250 NCBI chr17:13,135,216...13,143,954
Ensembl chr17:13,134,588...13,143,954
JBrowse link
G Tgm2 transglutaminase 2, C polypeptide affects response to substance
increases response to substance
multiple interactions
EXP
ISO
[TGM2 protein affects the susceptibility to Warfarin] which affects the susceptibility to Quercetin; TGM2 protein affects the susceptibility to Warfarin
TGM2 protein results in increased susceptibility to Warfarin
[Warfarin co-treated with Vitamin K] results in increased expression of and results in increased activity of TGM2 protein; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of and results in increased activity of TGM2 protein]; Quercetin inhibits the reaction [Warfarin results in increased activity of TGM2 protein]; Warfarin results in increased expression of and results in increased activity of TGM2 protein
CTD PMID:23117658 NCBI chr 2:157,958,325...157,988,312
Ensembl chr 2:157,958,322...157,988,356
JBrowse link
G Thop1 thimet oligopeptidase 1 increases expression EXP Warfarin results in increased expression of THOP1 mRNA CTD PMID:20493250 NCBI chr10:80,905,917...80,918,194
Ensembl chr10:80,905,869...80,918,393
JBrowse link
G Tnf tumor necrosis factor decreases expression
increases expression
multiple interactions
decreases secretion
ISO Warfarin results in decreased expression of TNF mRNA
Warfarin results in increased expression of TNF
[Warfarin co-treated with Vitamin K] results in increased expression of TNF mRNA
Warfarin results in decreased secretion of TNF protein
CTD PMID:21565690 PMID:22342526 PMID:23117658 PMID:26742017 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Trp53 transformation related protein 53 increases degradation
increases expression
ISO
EXP
Warfarin results in increased degradation of TP53 protein
Warfarin results in increased expression of TRP53 mRNA; Warfarin results in increased expression of TRP53 protein
CTD PMID:14634213 PMID:29358327 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Tuba1a tubulin, alpha 1A increases expression EXP Warfarin results in increased expression of TUBA1A mRNA CTD PMID:20493250 NCBI chr15:98,847,728...98,851,382
Ensembl chr15:98,847,718...98,851,584
JBrowse link
G Tuba1b tubulin, alpha 1B increases expression
decreases expression
EXP Warfarin results in increased expression of TUBA1B mRNA
Warfarin results in decreased expression of TUBA1B mRNA
CTD PMID:20493250 NCBI chr15:98,829,310...98,832,271
Ensembl chr15:98,829,306...98,832,446
JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression EXP Warfarin results in decreased expression of TUBB5 mRNA CTD PMID:20493250 NCBI chr17:36,144,812...36,149,193
Ensembl chr17:36,144,813...36,149,198
JBrowse link
G Tufm Tu translation elongation factor, mitochondrial decreases expression EXP Warfarin results in decreased expression of TUFM mRNA CTD PMID:20493250 NCBI chr 7:126,086,445...126,089,903
Ensembl chr 7:126,086,533...126,089,903
JBrowse link
G Tyro3 TYRO3 protein tyrosine kinase 3 decreases expression EXP Warfarin results in decreased expression of TYRO3 mRNA CTD PMID:18772604 PMID:27397090 NCBI chr 2:119,628,123...119,648,585
Ensembl chr 2:119,628,214...119,648,585
JBrowse link
G U2af2 U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2 increases expression EXP Warfarin results in increased expression of U2AF2 mRNA CTD PMID:20493250 NCBI chr 7:5,063,884...5,082,937
Ensembl chr 7:5,065,142...5,082,937
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 multiple interactions
affects response to substance
increases metabolic processing
ISO [UGT1A1 protein results in increased metabolism of Warfarin] which results in increased chemical synthesis of Glucuronides; [Warfarin binds to and results in decreased activity of UGT1A1 protein] which results in decreased glucuronidation of Estradiol; Warfarin binds to and results in decreased activity of UGT1A1 protein; Warfarin inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Estradiol]
UGT1A1 gene SNP affects the susceptibility to Warfarin; UGT1A1 polymorphism affects the susceptibility to Warfarin
CTD PMID:19408964 PMID:25312789 PMID:25393417 PMID:26223945 NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719
JBrowse link
G Ugt1a10 UDP glycosyltransferase 1 family, polypeptide A10 multiple interactions
increases metabolic processing
ISO [UGT1A10 protein results in increased metabolism of Warfarin] which results in increased chemical synthesis of Glucuronides CTD PMID:19408964 NCBI chr 1:87,983,133...88,147,724
Ensembl chr 1:87,983,110...88,146,726
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 multiple interactions ISO [Warfarin binds to and results in increased activity of UGT1A3 protein] which results in increased glucuronidation of Vorinostat; Warfarin binds to and results in increased activity of UGT1A3 protein; Warfarin promotes the reaction [UGT1A3 protein results in increased glucuronidation of Vorinostat] CTD PMID:25393417 NCBI chr 1:88,128,333...88,147,724
Ensembl chr 1:88,128,323...88,146,719
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase 1 family, polypeptide A9 multiple interactions ISO [Warfarin binds to and affects the activity of UGT1A9 protein] which affects the glucuronidation of Propofol; Warfarin affects the reaction [UGT1A9 protein results in increased glucuronidation of Propofol]; Warfarin binds to and affects the activity of UGT1A9 protein CTD PMID:25393417 NCBI chr 1:87,998,501...88,147,724
Ensembl chr 1:87,998,522...88,146,719
JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 multiple interactions ISO [Warfarin binds to and results in decreased activity of UGT2B17 protein] which results in decreased glucuronidation of vorinostat; Warfarin binds to and results in decreased activity of UGT2B17 protein; Warfarin inhibits the reaction [UGT2B17 protein results in increased glucuronidation of vorinostat] CTD PMID:25393417 NCBI chr 5:87,064,498...87,074,362
Ensembl chr 5:87,064,497...87,074,389
JBrowse link
G Ugt2b34 UDP glucuronosyltransferase 2 family, polypeptide B34 multiple interactions ISO [Warfarin binds to and results in decreased activity of UGT2B7 protein] which results in decreased glucuronidation of Zidovudine; Warfarin binds to and results in decreased activity of UGT2B7 protein; Warfarin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine] CTD PMID:25393417 NCBI chr 5:87,037,613...87,054,805
Ensembl chr 5:87,037,626...87,054,796
JBrowse link
G Usp5 ubiquitin specific peptidase 5 (isopeptidase T) decreases expression EXP Warfarin results in decreased expression of USP5 mRNA CTD PMID:20493250 NCBI chr 6:124,791,982...124,806,404
Ensembl chr 6:124,791,982...124,806,447
JBrowse link
G Vcp valosin containing protein decreases expression
increases expression
EXP Warfarin results in decreased expression of VCP mRNA
Warfarin results in increased expression of VCP mRNA
CTD PMID:20493250 NCBI chr 4:42,979,964...43,000,507
Ensembl chr 4:42,979,963...43,000,507
JBrowse link
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor affects response to substance ISO VDR gene SNP affects the susceptibility to Warfarin CTD PMID:28262345 PMID:29298995 NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511
JBrowse link
G Vegfa vascular endothelial growth factor A affects response to substance
multiple interactions
ISO VEGFA gene SNP affects the susceptibility to Warfarin
epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of VEGFA mRNA]]; epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of VEGFA protein]]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of VEGFA mRNA]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of VEGFA protein]
CTD PMID:31068094 PMID:36162953 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
JBrowse link
G Vim vimentin decreases expression ISO Warfarin results in decreased expression of VIM protein CTD PMID:26206560 NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637
JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 multiple interactions
decreases activity
affects abundance
decreases response to substance
affects response to substance
affects metabolic processing
increases response to substance
decreases metabolic processing
ISO
EXP
[CYP4F2 gene polymorphism co-treated with VKORC1 gene mutant form] affects the susceptibility to Warfarin; Warfarin binds to and results in decreased activity of VKORC1 protein; Warfarin inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]; Warfarin inhibits the reaction [VKORC1 protein results in increased reduction of vitamin K1 oxide]
Warfarin results in decreased activity of VKORC1 protein
VKORC1 gene polymorphism affects the abundance of Warfarin
VKORC1 3' UTR results in decreased susceptibility to Warfarin; VKORC1 gene mutant form results in decreased susceptibility to Warfarin; VKORC1 gene polymorphism results in decreased susceptibility to Warfarin
VKORC1 3' UTR SNP affects the susceptibility to Warfarin; VKORC1 affects the susceptibility to Warfarin; VKORC1 alternative form affects the susceptibility to Warfarin; VKORC1 gene affects the susceptibility to Warfarin; VKORC1 gene mutant form affects the susceptibility to Warfarin; VKORC1 gene polymorphism affects the susceptibility to Warfarin; VKORC1 gene SNP affects the susceptibility to Warfarin; VKORC1 intron polymorphism affects the susceptibility to Warfarin; VKORC1 intron SNP affects the susceptibility to Warfarin; VKORC1 polymorphism affects the susceptibility to Warfarin; VKORC1 promoter polymorphism affects the susceptibility to Warfarin; VKORC1 promoter SNP affects the susceptibility to Warfarin; VKORC1 protein affects the susceptibility to Warfarin; VKORC1 protein polymorphism affects the susceptibility to Warfarin; VKORC1 protein SNP affects the susceptibility to Warfarin; VKORC1 SNP affects the susceptibility to Warfarin
Warfarin inhibits the reaction [VKORC1 protein affects the reduction of vitamin K1 oxide]
VKORC1 gene mutant form results in decreased susceptibility to Warfarin; VKORC1 protein polymorphism results in decreased susceptibility to Warfarin
VKORC1 protein mutant form affects the susceptibility to Warfarin
VKORC1 protein affects the metabolism of Warfarin
VKORC1 intron polymorphism results in increased susceptibility to Warfarin; VKORC1 protein results in increased susceptibility to Warfarin; VKORC1 results in increased susceptibility to Warfarin
VKORC1 gene polymorphism results in decreased metabolism of Warfarin
CTD PMID:14765194 PMID:14765195 PMID:15358623 PMID:15578879 PMID:15630486 More... NCBI chr 7:127,492,235...127,494,833
Ensembl chr 7:127,485,399...127,494,626
Ensembl chr 7:127,485,399...127,494,626
JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 multiple interactions ISO Warfarin affects the reaction [VKORC1L1 protein results in increased reduction of vitamin K1 oxide]; Warfarin binds to and results in decreased activity of VKORC1L1 protein; Warfarin inhibits the reaction [VKORC1L1 protein results in increased metabolism of vitamin K1 oxide]; Warfarin inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]; Warfarin inhibits the reaction [VKORC1L1 protein results in increased reduction of vitamin K1 oxide] CTD PMID:23710884 PMID:23928358 PMID:29581108 NCBI chr 5:129,970,950...130,015,533
Ensembl chr 5:129,970,811...130,015,533
JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide increases expression EXP Warfarin results in increased expression of YWHAE mRNA CTD PMID:20493250 NCBI chr11:75,620,121...75,656,667
Ensembl chr11:75,623,695...75,656,671
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 decreases expression ISO Warfarin results in decreased expression of ZEB1 protein CTD PMID:26206560 NCBI chr18:5,591,330...5,775,468
Ensembl chr18:5,591,860...5,775,467
JBrowse link
zingerone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
affects activity
ISO zingerone affects the reaction [Vancomycin affects the activity of ACHE protein]
zingerone affects the activity of ACHE protein
CTD PMID:31454121 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO zingerone results in decreased expression of and results in decreased phosphorylation of AKT1 protein CTD PMID:32905641 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Akt2 thymoma viral proto-oncogene 2 increases expression
multiple interactions
ISO zingerone results in increased expression of AKT2 mRNA
zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of AKT2 mRNA]
CTD PMID:36822304 NCBI chr 7:27,290,977...27,340,251
Ensembl chr 7:27,290,977...27,340,251
JBrowse link
G Ar androgen receptor multiple interactions ISO zingerone binds to and results in decreased activity of AR protein CTD PMID:20226658 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821
JBrowse link
G Bax BCL2-associated X protein multiple interactions
increases expression
ISO zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BAX mRNA]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BAX protein]; zingerone inhibits the reaction [Ethanol results in increased expression of BAX protein]
zingerone results in increased expression of BAX protein
CTD PMID:28442378 PMID:31476248 PMID:36822304 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bche butyrylcholinesterase multiple interactions
affects activity
ISO zingerone affects the reaction [Vancomycin affects the activity of BCHE protein]
zingerone affects the activity of BCHE protein
CTD PMID:31454121 NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
increases expression
decreases expression
ISO zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of BCL2 mRNA]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of BCL2 protein]; zingerone inhibits the reaction [Ethanol results in decreased expression of BCL2 protein]
zingerone results in increased expression of BCL2 mRNA
zingerone results in decreased expression of BCL2 protein
CTD PMID:28442378 PMID:31476248 PMID:36822304 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions ISO zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BECN1 mRNA] CTD PMID:36822304 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112
JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO zingerone results in increased expression of BID protein CTD PMID:31476248 NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814
JBrowse link
G Casp3 caspase 3 multiple interactions ISO zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CASP3 mRNA]; zingerone inhibits the reaction [Ethanol results in increased expression of CASP3 protein] CTD PMID:28442378 PMID:36822304 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp9 caspase 9 multiple interactions ISO zingerone inhibits the reaction [Ethanol results in increased expression of CASP9 protein] CTD PMID:28442378 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Cat catalase multiple interactions ISO zingerone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased activity of CAT protein]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased activity of CAT protein] CTD PMID:31476248 PMID:36822304 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO zingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CCND1] CTD PMID:30720227 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Cyb5a cytochrome b5 type A (microsomal) multiple interactions ISO zingerone inhibits the reaction [Ethanol results in increased activity of CYB5A protein] CTD PMID:28442378 NCBI chr18:84,869,463...84,897,996
Ensembl chr18:84,856,829...84,897,996
JBrowse link
G Cyb5r3 cytochrome b5 reductase 3 multiple interactions ISO zingerone inhibits the reaction [Ethanol results in increased activity of CYB5R3 protein] CTD PMID:28442378 NCBI chr15:83,037,696...83,060,641
Ensembl chr15:83,037,695...83,056,793
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO zingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CYP2E1 protein]; zingerone inhibits the reaction [Ethanol results in increased activity of CYP2E1 protein] CTD PMID:28442378 PMID:30720227 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
JBrowse link
G Foxo1 forkhead box O1 multiple interactions
increases expression
ISO zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of FOXO1 mRNA]
zingerone results in increased expression of FOXO1 mRNA
CTD PMID:36822304 NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642
JBrowse link
G Gsr glutathione reductase multiple interactions ISO zingerone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased activity of GSR protein] CTD PMID:31476248 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase multiple interactions ISO zingerone inhibits the reaction [Ethanol results in increased activity of HMGCR protein] CTD PMID:28442378 NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444
JBrowse link
G Ifng interferon gamma multiple interactions EXP zingerone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IFNG protein] CTD PMID:29289488 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of IL1B mRNA]
zingerone results in decreased expression of IL1B mRNA; zingerone results in decreased expression of IL1B protein
CTD PMID:36822304 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO
zingerone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]
zingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of IL6 protein]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of IL6 mRNA]
CTD PMID:29289488 PMID:30720227 PMID:36822304 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions EXP zingerone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of IRF3 protein] CTD PMID:29289488 NCBI chr 7:44,647,072...44,652,272
Ensembl chr 7:44,647,072...44,652,272
JBrowse link
G Lcat lecithin cholesterol acyltransferase multiple interactions ISO zingerone inhibits the reaction [Ethanol results in decreased activity of LCAT protein] CTD PMID:28442378 NCBI chr 8:106,666,183...106,670,034
Ensembl chr 8:106,666,183...106,670,014
JBrowse link
G Lpl lipoprotein lipase multiple interactions ISO zingerone inhibits the reaction [Ethanol results in decreased activity of LPL protein] CTD PMID:28442378 NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 decreases phosphorylation ISO zingerone results in decreased phosphorylation of MAPK1 protein CTD PMID:20211236 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk14 mitogen-activated protein kinase 14 multiple interactions ISO zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of MAPK14 mRNA] CTD PMID:36822304 NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380
JBrowse link
G Mapk15 mitogen-activated protein kinase 15 multiple interactions ISO zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of MAPK15 mRNA] CTD PMID:36822304 NCBI chr15:75,865,581...75,871,002
Ensembl chr15:75,865,618...75,871,003
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 decreases phosphorylation ISO zingerone results in decreased phosphorylation of MAPK3 protein CTD PMID:20211236 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases expression
multiple interactions
ISO zingerone results in increased expression of MAPK8 mRNA
zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of MAPK8 mRNA]
CTD PMID:36822304 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 multiple interactions ISO zingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein] CTD PMID:30720227 NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO zingerone results in decreased expression of and results in decreased phosphorylation of MTOR protein CTD PMID:32905641 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO zingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of NFE2L2 protein] CTD PMID:30720227 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 affects localization
multiple interactions
decreases expression
ISO zingerone affects the localization of NFKB1 protein
zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of NFKB1 mRNA]
zingerone results in decreased expression of NFKB1 mRNA
CTD PMID:20211236 PMID:36822304 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP zingerone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of NFKBIA protein] CTD PMID:29289488 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
JBrowse link
G Nos2 nitric oxide synthase 2, inducible decreases expression
multiple interactions
ISO zingerone results in decreased expression of NOS2 protein
zingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of NOS2 protein]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of NOS2 mRNA]
CTD PMID:20211236 PMID:30720227 PMID:36822304 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Nphs1 nephrosis 1, nephrin multiple interactions ISO zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of NPHS1 protein] CTD PMID:36822304 NCBI chr 7:30,157,259...30,188,048
Ensembl chr 7:30,157,740...30,186,648
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions ISO zingerone inhibits the reaction [Ethanol results in decreased activity of NQO1 protein] CTD PMID:28442378 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Or5d18 olfactory receptor family 5 subfamily D member 18 multiple interactions EXP zingerone binds to and results in increased activity of OR5D18 protein CTD PMID:21142015 NCBI chr 2:87,864,540...87,865,481
Ensembl chr 2:87,862,632...87,868,043
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO zingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein] CTD PMID:30720227 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
JBrowse link
G Pon1 paraoxonase 1 affects activity
multiple interactions
ISO zingerone affects the activity of PON1 protein
zingerone affects the reaction [Vancomycin results in decreased activity of PON1 protein]
CTD PMID:31454121 NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO zingerone inhibits the reaction [Ethanol results in increased activity of POR protein] CTD PMID:28442378 NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
ISO zingerone results in decreased expression of PTGS2 protein
zingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PTGS2 protein]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of PTGS2 mRNA]
CTD PMID:20211236 PMID:30720227 PMID:36822304 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO zingerone affects the localization of and results in increased phosphorylation of RELA protein; zingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of RELA protein] CTD PMID:20211236 PMID:30720227 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO zingerone inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein] CTD PMID:28904557 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP zingerone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR4 protein] CTD PMID:29289488 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
EXP
ISO
zingerone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]
zingerone results in decreased expression of TNF mRNA
zingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of TNF protein]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TNF mRNA]
CTD PMID:29289488 PMID:30720227 PMID:36822304 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    chemical entity 22208
      group 22072
        inorganic group 21029
          oxo group 20172
            organic oxo compound 20172
              carbonyl compound 20172
                ketone 17949
                  methyl ketone 803
                    (-)-rotiorin 0
                    (2R)-23-oxotetracosan-2-yl alpha-L-ascaroside 0
                    (2S)-5-Hydroxy-7-methoxy-8-[(E)-3-oxo-1-butenyl]flavanone 0
                    (4E)-hept-4-en-2-one 0
                    (4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal 0
                    (E,E)-2-methyl-6-oxohepta-2,4-dienal 0
                    (E,E)-2-methyl-6-oxohepta-2,4-dienol 0
                    (S)-5'-oxoaverantin 0
                    1-(1-methylpyrrolidin-2-yl)acetone + 0
                    1-(2-methylenecyclopropyl)ethanone 0
                    1-(3'-\{1-[2-(morpholin-4-yl)ethyl]pyrazol-3-yl\}[1,1'-biphenyl]-3-yl)ethan-1-one 0
                    1-(4-hydroxy-2,6-dimethyl-5,6-dihydropyridin-3-yl)ethanone 0
                    1-cyclohexylethanone 0
                    1-hydroxy-1-phenylpropan-2-one + 0
                    1-isopropoxyacetone 0
                    1-methyl-2-acetylpyrrole 0
                    2',4',6'-trihydroxyacetophenone + 1
                    2,3,6,8,9-pentahydroxy-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracen-1-one 0
                    2,4-diacetylphloroglucinol 0
                    2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde 0
                    2,5-hexanedione 185
                    2-acetyl-1-pyrroline 0
                    2-acetyl-5-methylfuran 0
                    2-acetyl-5-methylthiophene 0
                    2-acetylfuran 0
                    2-acetylpyrrole 0
                    2-hydroxy-(22-27)-hexanorcucurbita-1,5,16-triene-3,11,20-trione 2-O-beta-D-glucopyranoside 0
                    2-octanone 0
                    3,3,4,4-tetramethyl-2-pentanone 0
                    3,3-dimethylbutan-2-one 0
                    3-(phenethylamino)-butan-2-one 0
                    3-(phenethylamino)-butan-2-one(1+) 0
                    3-O-methyl-isosecotanapartholide 0
                    3-acetyl-2,5-dimethylfuran 0
                    3-acetylbenzamide 0
                    3-acetylchlorophyllide a 0
                    3-cyano-2-butanone 0
                    3-ethoxy-2-butanone 0
                    3-hexen-2-one 0
                    3-hydroxy-2,4-dioxopentyl phosphate 0
                    3-hydroxy-alpha-ionone 0
                    3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside 0
                    4'-O-demethylknipholone-4'-O-beta-D-glucopyranoside 0
                    4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one + 195
                    4-hydroxybutan-2-one 0
                    4-mercapto-4-methylpentan-2-one 0
                    4-penten-2-one 0
                    5-acetyl-2,6-dimethyl-1,2,3,4-tetrahydropyridin-4-one 0
                    5-hydroxypentan-2-one 0
                    5-nonen-2-one + 0
                    6,8-dihydroxy-3-(2-oxopropyl)-isocoumarin 0
                    6-acetyl-2-amino-3,7,8,9-tetrahydropyrimido[4,5-b][1,4]diazepin-4-one 0
                    7-octen-2-one 0
                    BI00036838 0
                    BMS-192548 0
                    CBL0137 0
                    GTRI-02 0
                    RH-24580 0
                    TAN-1612 0
                    acenocoumarol + 15
                    acepromazine 1
                    aceprometazine + 0
                    acetoin + 3
                    acetone + 19
                    acetophenones + 160
                    aglaiabbreviatin C 0
                    alpha-ionone + 3
                    alpha-irone 0
                    aminoacetone 4
                    amrubicin + 0
                    apocynin 138
                    ascr#2 + 0
                    ascr#4 0
                    bacteriochlorophyllide a + 0
                    benzyl 2-methyl-3-oxobutanoate 0
                    butan-2-one + 8
                    buten-2-one 3
                    butyn-2-one 0
                    caminoside A 0
                    caudatin-3-O-beta-cymaropyranoside 0
                    cercosporamide 0
                    chaetocyclinone C 0
                    cspyrone B1 0
                    curamycin A 0
                    decan-2-one 0
                    dehydrocitreoisocoumarin 0
                    dihydrodehydro-beta-ionone 0
                    drummondin D 0
                    drummondin E 0
                    drummondin F 0
                    dysolenticin G 0
                    dzununcanone 0
                    epi-isochromophilone II 0
                    ethylzingerone 0
                    flavaspidic acid AB 0
                    gaboroquinone A 0
                    geumonoid 0
                    grasshopper ketone 0
                    heptan-2-one 5
                    hydroxyacetone + 0
                    hypocrellin D 0
                    iloperidone 1
                    isodrummondin D 0
                    isosecotanapartholide 0
                    kebuzone 0
                    khekadaengoside K 0
                    kidjoranin-3-O-alpha-diginopyranosyl-(1->4)-beta-cymaropyranoside 0
                    kidjoranin-3-O-beta-digitoxopyranoside 0
                    knipholone + 0
                    mallotophilippen B 0
                    marinacarboline B 0
                    mono(2-ethyl-5-oxohexyl) phthalate 37
                    muqubilone 0
                    nabumetone 7
                    nigerapyrone C 0
                    nigerapyrone D 0
                    nigerapyrone E 0
                    nonan-2-one 0
                    oxidized Latia luciferin 0
                    p-Ts-L-Lys-Me 0
                    pentan-2-one + 0
                    pentane-2,3-dione 159
                    phenylacetone 0
                    platanic acid 0
                    raspberry ketone 23
                    rel-2alpha,3alpha,23-trihydroxy-19-oxo-18,19-seco-urs-11,13(18)-dien-28-oic acid 0
                    rel-2alpha,3beta,23-trihydroxy-19-oxo-18,19-seco-12,17-dien-28-norursane 0
                    rotiorinol A 0
                    rotiorinol B 0
                    rotiorinol C 0
                    rottlerin 116
                    rubrorotiorin 0
                    semi-beta-carotenone 0
                    spirolaurenone 0
                    streptokordin 0
                    sulcatone 0
                    tenuazonic acid 0
                    teprenone 18
                    traseolide + 0
                    tridecan-2-one 0
                    undecan-2-one 11
                    usnic acid + 69
                    xyloketal D 0
                    zingerone 46
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            heteroorganic entity 21482
                              organochalcogen compound 20966
                                organooxygen compound 20806
                                  carbonyl compound 20172
                                    ketone 17949
                                      methyl ketone 803
                                        (-)-rotiorin 0
                                        (2R)-23-oxotetracosan-2-yl alpha-L-ascaroside 0
                                        (2S)-5-Hydroxy-7-methoxy-8-[(E)-3-oxo-1-butenyl]flavanone 0
                                        (4E)-hept-4-en-2-one 0
                                        (4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal 0
                                        (E,E)-2-methyl-6-oxohepta-2,4-dienal 0
                                        (E,E)-2-methyl-6-oxohepta-2,4-dienol 0
                                        (S)-5'-oxoaverantin 0
                                        1-(1-methylpyrrolidin-2-yl)acetone + 0
                                        1-(2-methylenecyclopropyl)ethanone 0
                                        1-(3'-\{1-[2-(morpholin-4-yl)ethyl]pyrazol-3-yl\}[1,1'-biphenyl]-3-yl)ethan-1-one 0
                                        1-(4-hydroxy-2,6-dimethyl-5,6-dihydropyridin-3-yl)ethanone 0
                                        1-cyclohexylethanone 0
                                        1-hydroxy-1-phenylpropan-2-one + 0
                                        1-isopropoxyacetone 0
                                        1-methyl-2-acetylpyrrole 0
                                        2',4',6'-trihydroxyacetophenone + 1
                                        2,3,6,8,9-pentahydroxy-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracen-1-one 0
                                        2,4-diacetylphloroglucinol 0
                                        2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde 0
                                        2,5-hexanedione 185
                                        2-acetyl-1-pyrroline 0
                                        2-acetyl-5-methylfuran 0
                                        2-acetyl-5-methylthiophene 0
                                        2-acetylfuran 0
                                        2-acetylpyrrole 0
                                        2-hydroxy-(22-27)-hexanorcucurbita-1,5,16-triene-3,11,20-trione 2-O-beta-D-glucopyranoside 0
                                        2-octanone 0
                                        3,3,4,4-tetramethyl-2-pentanone 0
                                        3,3-dimethylbutan-2-one 0
                                        3-(phenethylamino)-butan-2-one 0
                                        3-(phenethylamino)-butan-2-one(1+) 0
                                        3-O-methyl-isosecotanapartholide 0
                                        3-acetyl-2,5-dimethylfuran 0
                                        3-acetylbenzamide 0
                                        3-acetylchlorophyllide a 0
                                        3-cyano-2-butanone 0
                                        3-ethoxy-2-butanone 0
                                        3-hexen-2-one 0
                                        3-hydroxy-2,4-dioxopentyl phosphate 0
                                        3-hydroxy-alpha-ionone 0
                                        3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside 0
                                        4'-O-demethylknipholone-4'-O-beta-D-glucopyranoside 0
                                        4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one + 195
                                        4-hydroxybutan-2-one 0
                                        4-mercapto-4-methylpentan-2-one 0
                                        4-penten-2-one 0
                                        5-acetyl-2,6-dimethyl-1,2,3,4-tetrahydropyridin-4-one 0
                                        5-hydroxypentan-2-one 0
                                        5-nonen-2-one + 0
                                        6,8-dihydroxy-3-(2-oxopropyl)-isocoumarin 0
                                        6-acetyl-2-amino-3,7,8,9-tetrahydropyrimido[4,5-b][1,4]diazepin-4-one 0
                                        7-octen-2-one 0
                                        BI00036838 0
                                        BMS-192548 0
                                        CBL0137 0
                                        GTRI-02 0
                                        RH-24580 0
                                        TAN-1612 0
                                        acenocoumarol + 15
                                        acepromazine 1
                                        aceprometazine + 0
                                        acetoin + 3
                                        acetone + 19
                                        acetophenones + 160
                                        aglaiabbreviatin C 0
                                        alpha-ionone + 3
                                        alpha-irone 0
                                        aminoacetone 4
                                        amrubicin + 0
                                        apocynin 138
                                        ascr#2 + 0
                                        ascr#4 0
                                        bacteriochlorophyllide a + 0
                                        benzyl 2-methyl-3-oxobutanoate 0
                                        butan-2-one + 8
                                        buten-2-one 3
                                        butyn-2-one 0
                                        caminoside A 0
                                        caudatin-3-O-beta-cymaropyranoside 0
                                        cercosporamide 0
                                        chaetocyclinone C 0
                                        cspyrone B1 0
                                        curamycin A 0
                                        decan-2-one 0
                                        dehydrocitreoisocoumarin 0
                                        dihydrodehydro-beta-ionone 0
                                        drummondin D 0
                                        drummondin E 0
                                        drummondin F 0
                                        dysolenticin G 0
                                        dzununcanone 0
                                        epi-isochromophilone II 0
                                        ethylzingerone 0
                                        flavaspidic acid AB 0
                                        gaboroquinone A 0
                                        geumonoid 0
                                        grasshopper ketone 0
                                        heptan-2-one 5
                                        hydroxyacetone + 0
                                        hypocrellin D 0
                                        iloperidone 1
                                        isodrummondin D 0
                                        isosecotanapartholide 0
                                        kebuzone 0
                                        khekadaengoside K 0
                                        kidjoranin-3-O-alpha-diginopyranosyl-(1->4)-beta-cymaropyranoside 0
                                        kidjoranin-3-O-beta-digitoxopyranoside 0
                                        knipholone + 0
                                        mallotophilippen B 0
                                        marinacarboline B 0
                                        mono(2-ethyl-5-oxohexyl) phthalate 37
                                        muqubilone 0
                                        nabumetone 7
                                        nigerapyrone C 0
                                        nigerapyrone D 0
                                        nigerapyrone E 0
                                        nonan-2-one 0
                                        oxidized Latia luciferin 0
                                        p-Ts-L-Lys-Me 0
                                        pentan-2-one + 0
                                        pentane-2,3-dione 159
                                        phenylacetone 0
                                        platanic acid 0
                                        raspberry ketone 23
                                        rel-2alpha,3alpha,23-trihydroxy-19-oxo-18,19-seco-urs-11,13(18)-dien-28-oic acid 0
                                        rel-2alpha,3beta,23-trihydroxy-19-oxo-18,19-seco-12,17-dien-28-norursane 0
                                        rotiorinol A 0
                                        rotiorinol B 0
                                        rotiorinol C 0
                                        rottlerin 116
                                        rubrorotiorin 0
                                        semi-beta-carotenone 0
                                        spirolaurenone 0
                                        streptokordin 0
                                        sulcatone 0
                                        tenuazonic acid 0
                                        teprenone 18
                                        traseolide + 0
                                        tridecan-2-one 0
                                        undecan-2-one 11
                                        usnic acid + 69
                                        xyloketal D 0
                                        zingerone 46
paths to the root