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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dexmethylphenidate
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Accession:CHEBI:51860 term browser browse the term
Definition:A methyl phenyl(piperidin-2-yl)acetate in which both stereocentres have R configuration. It is the active enantiomer in the racemic drug methylphenidate.
Synonyms:exact_synonym: methyl (2R)-phenyl[(2R)-piperidin-2-yl]acetate
 related_synonym: (+)-threo-methylphenidate;   Formula=C14H19NO2;   InChI=1S/C14H19NO2/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3/t12-,13-/m1/s1;   InChIKey=DUGOZIWVEXMGBE-CHWSQXEVSA-N;   SMILES=COC(=O)[C@@H]([C@H]1CCCCN1)c1ccccc1;   d-threo-methylphenidate;   dexmethylphenidatum;   dexmetilfenidato;   methyl (R)-phenyl[(R)-piperidin-2-yl]acetate
 xref: Beilstein:6116309;   CAS:40431-64-9;   Drug_Central:836;   Wikipedia:Dexmethylphenidate
 cyclic_relationship: is_enantiomer_of CHEBI:51857


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methylphenidate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtpbp1 ATP/GTP binding carboxypeptidase 1 increases expression ISO Methylphenidate results in increased expression of AGTPBP1 mRNA CTD PMID:22470460 NCBI chr17:5,120,540...5,238,874
Ensembl chr17:5,120,609...5,238,869 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 decreases expression ISO Methylphenidate results in decreased expression of AKR1B1 mRNA CTD PMID:22470460 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Ap2b1 adaptor related protein complex 2 subunit beta 1 increases expression ISO Methylphenidate results in increased expression of AP2B1 mRNA CTD PMID:22470460 NCBI chr10:68,099,397...68,205,023
Ensembl chr10:68,099,547...68,205,013 		JBrowse link
G Arap1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 decreases expression ISO Methylphenidate results in decreased expression of ARAP1 mRNA CTD PMID:22470460 NCBI chr 1:155,748,622...155,814,186
Ensembl chr 1:155,748,652...155,814,184 		JBrowse link
G Arc activity-regulated cytoskeleton-associated protein affects expression EXP Methylphenidate affects the expression of ARC mRNA CTD PMID:19222557 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378 		JBrowse link
G Arih2 ariadne RBR E3 ubiquitin protein ligase 2 decreases expression ISO Methylphenidate results in decreased expression of ARIH2 mRNA CTD PMID:22470460 NCBI chr 8:109,296,738...109,355,909
Ensembl chr 8:109,296,738...109,355,852 		JBrowse link
G Armc9 armadillo repeat containing 9 decreases expression ISO Methylphenidate results in decreased expression of ARMC9 mRNA CTD PMID:22470460 NCBI chr 9:86,802,791...86,928,611
Ensembl chr 9:86,802,868...86,928,860 		JBrowse link
G Atg5 autophagy related 5 increases expression EXP Methylphenidate results in increased expression of ATG5 mRNA CTD PMID:32746681 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G B4galt4 beta-1,4-galactosyltransferase 4 decreases expression ISO Methylphenidate results in decreased expression of B4GALT4 mRNA CTD PMID:22470460 NCBI chr11:61,995,807...62,021,751
Ensembl chr11:61,995,814...62,021,671 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP Methylphenidate results in increased expression of BAX mRNA CTD PMID:32746681 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression EXP Methylphenidate results in increased expression of BBC3 mRNA CTD PMID:32746681 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl9 BCL9, transcription coactivator decreases expression ISO Methylphenidate results in decreased expression of BCL9 mRNA CTD PMID:22470460 NCBI chr 2:184,760,616...184,846,261
Ensembl chr 2:184,760,618...184,786,435 		JBrowse link
G Bdnf brain-derived neurotrophic factor affects expression
decreases expression
multiple interactions		 EXP
ISO		 Methylphenidate affects the expression of BDNF mRNA
Methylphenidate results in decreased expression of BDNF mRNA
[staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [Methylphenidate inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]]; Methylphenidate inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]		 CTD PMID:19222557 PMID:22470460 PMID:24394491 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Becn1 beclin 1 increases expression EXP Methylphenidate results in increased expression of BECN1 mRNA CTD PMID:32746681 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G C2 complement C2 increases expression ISO Methylphenidate results in increased expression of C2 mRNA CTD PMID:22470460 NCBI chr20:3,951,474...3,970,376
Ensembl chr20:3,951,474...3,976,505 		JBrowse link
G Cald1 caldesmon 1 increases expression ISO Methylphenidate results in increased expression of CALD1 mRNA CTD PMID:22470460 NCBI chr 4:63,265,781...63,446,938
Ensembl chr 4:63,265,942...63,446,932 		JBrowse link
G Casp3 caspase 3 increases expression EXP Methylphenidate results in increased expression of CASP3 mRNA CTD PMID:32746681 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases expression EXP Methylphenidate results in increased expression of CASP8 mRNA CTD PMID:32746681 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Cat catalase increases activity EXP Methylphenidate results in increased activity of CAT protein CTD PMID:32746681 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cbr3 carbonyl reductase 3 increases expression ISO Methylphenidate results in increased expression of CBR3 mRNA CTD PMID:22470460 NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875 		JBrowse link
G Ccdc166 coiled-coil domain containing 166 decreases expression ISO Methylphenidate results in decreased expression of CCDC166 mRNA CTD PMID:22470460 NCBI chr 7:107,693,572...107,695,375
Ensembl chr 7:107,693,574...107,695,375 		JBrowse link
G Ccdc91 coiled-coil domain containing 91 decreases expression ISO Methylphenidate results in decreased expression of CCDC91 mRNA CTD PMID:22470460 NCBI chr 4:180,402,327...180,574,364
Ensembl chr 4:180,402,376...180,574,364 		JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 increases expression ISO Methylphenidate results in increased expression of CDK5R1 mRNA CTD PMID:22470460 NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP Methylphenidate results in increased expression of CDKN1A mRNA CTD PMID:32746681 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Ces1d carboxylesterase 1D multiple interactions
increases metabolic processing
increases hydrolysis		 ISO [CES1 protein results in increased hydrolysis of Methylphenidate] which results in increased chemical synthesis of ritalinic acid; Aripiprazole inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]; CES1 gene mutant form results in decreased metabolism of and results in increased abundance of Methylphenidate; Fluoxetine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]; Perphenazine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]; Thioridazine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]
CES1 protein results in increased metabolism of Methylphenidate
aripiprazole inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]		 CTD PMID:15082749 PMID:18485328 PMID:20097249 PMID:25445008 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Chd2 chromodomain helicase DNA binding protein 2 increases expression ISO Methylphenidate results in increased expression of CHD2 mRNA CTD PMID:22470460 NCBI chr 1:127,188,146...127,317,041
Ensembl chr 1:127,190,059...127,300,502 		JBrowse link
G Chga chromogranin A decreases expression ISO Methylphenidate results in decreased expression of CHGA mRNA CTD PMID:22470460 NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398 		JBrowse link
G Chid1 chitinase domain containing 1 decreases expression ISO Methylphenidate results in decreased expression of CHID1 mRNA CTD PMID:22470460 NCBI chr 1:196,594,357...196,629,700
Ensembl chr 1:196,587,509...196,629,606 		JBrowse link
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit decreases expression ISO Methylphenidate results in decreased expression of CHRNA6 mRNA CTD PMID:22470460 NCBI chr16:64,697,741...64,704,441
Ensembl chr16:64,697,741...64,704,441 		JBrowse link
G Chst8 carbohydrate sulfotransferase 8 decreases expression ISO Methylphenidate results in decreased expression of CHST8 mRNA CTD PMID:22470460 NCBI chr 1:87,294,144...87,435,900
Ensembl chr 1:87,294,540...87,435,900 		JBrowse link
G Clpx caseinolytic mitochondrial matrix peptidase chaperone subunit X increases expression ISO Methylphenidate results in increased expression of CLPX mRNA CTD PMID:22470460 NCBI chr 8:65,805,460...65,845,643
Ensembl chr 8:65,805,511...65,845,082 		JBrowse link
G Cnnm1 cyclin and CBS domain divalent metal cation transport mediator 1 increases expression ISO Methylphenidate results in increased expression of CNNM1 mRNA CTD PMID:22470460 NCBI chr 1:242,296,367...242,354,957
Ensembl chr 1:242,296,422...242,353,513 		JBrowse link
G Cnot6l CCR4-NOT transcription complex, subunit 6-like decreases expression ISO Methylphenidate results in decreased expression of CNOT6L mRNA CTD PMID:22470460 NCBI chr14:13,410,499...13,502,511
Ensembl chr14:13,411,281...13,498,203 		JBrowse link
G Cnr1 cannabinoid receptor 1 increases expression ISO Methylphenidate results in increased expression of CNR1 mRNA CTD PMID:22470460 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Comtd1 catechol-O-methyltransferase domain containing 1 decreases expression ISO Methylphenidate results in decreased expression of COMTD1 mRNA CTD PMID:22470460 NCBI chr15:2,459,783...2,462,895
Ensembl chr15:2,459,783...2,462,895 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
decreases expression		 EXP [Fluoxetine co-treated with Methylphenidate] results in increased expression of CREB1 mRNA; [Fluoxetine co-treated with Methylphenidate] results in increased phosphorylation of CREB1 protein
Methylphenidate results in decreased expression of CREB1 mRNA		 CTD PMID:21753012 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G D2hgdh D-2-hydroxyglutarate dehydrogenase decreases expression ISO Methylphenidate results in decreased expression of D2HGDH mRNA CTD PMID:22470460 NCBI chr 9:94,350,555...94,368,384
Ensembl chr 9:94,350,576...94,368,382 		JBrowse link
G Dab2 DAB adaptor protein 2 increases expression ISO Methylphenidate results in increased expression of DAB2 mRNA CTD PMID:22470460 NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476 		JBrowse link
G Dapk3 death-associated protein kinase 3 decreases expression ISO Methylphenidate results in decreased expression of DAPK3 mRNA CTD PMID:22470460 NCBI chr 7:8,524,182...8,532,552
Ensembl chr 7:8,524,183...8,532,558 		JBrowse link
G Dhx35 DEAH-box helicase 35 decreases expression ISO Methylphenidate results in decreased expression of DHX35 mRNA CTD PMID:22470460 NCBI chr 3:147,450,178...147,507,473
Ensembl chr 3:147,450,163...147,507,451 		JBrowse link
G Drd1 dopamine receptor D1 multiple interactions EXP [SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to Methylphenidate CTD PMID:11454915 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
affects expression
decreases expression		 EXP
ISO		 [Raclopride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Methylphenidate
Methylphenidate affects the expression of DRD2 protein
Methylphenidate results in decreased expression of DRD2 mRNA		 CTD PMID:11454915 PMID:17599397 PMID:22470460 PMID:33647392 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Drd4 dopamine receptor D4 affects response to substance ISO DRD4 promoter mutant form affects the susceptibility to Methylphenidate CTD PMID:17023870 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553 		JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression		 EXP [Fluoxetine co-treated with Methylphenidate] results in increased expression of EGR1 mRNA; Fluoxetine promotes the reaction [Methylphenidate results in increased expression of EGR1 mRNA]; Methylphenidate promotes the reaction [Amphetamine results in increased expression of EGR1 mRNA]; SCH 23390 inhibits the reaction [Methylphenidate results in increased expression of EGR1 mRNA] CTD PMID:16549270 PMID:19931852 PMID:20020108 PMID:21753012 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Entpd5 ectonucleoside triphosphate diphosphohydrolase 5 decreases expression ISO Methylphenidate results in decreased expression of ENTPD5 mRNA CTD PMID:22470460 NCBI chr 6:104,019,095...104,055,311
Ensembl chr 6:104,019,185...104,055,530 		JBrowse link
G Epb41l1 erythrocyte membrane protein band 4.1-like 1 decreases expression ISO Methylphenidate results in decreased expression of EPB41L1 mRNA CTD PMID:22470460 NCBI chr 3:144,929,195...145,052,723
Ensembl chr 3:144,984,640...145,052,721 		JBrowse link
G Epha10 EPH receptor A10 decreases expression ISO Methylphenidate results in decreased expression of EPHA10 mRNA CTD PMID:22470460 NCBI chr 5:137,139,588...137,175,637
Ensembl chr 5:137,140,735...137,174,157 		JBrowse link
G Exog exo/endonuclease G decreases expression ISO Methylphenidate results in decreased expression of EXOG mRNA CTD PMID:22470460 NCBI chr 8:119,184,974...119,204,819
Ensembl chr 8:119,185,136...119,204,672 		JBrowse link
G Fank1 fibronectin type III and ankyrin repeat domains 1 decreases expression ISO Methylphenidate results in decreased expression of FANK1 mRNA CTD PMID:22470460 NCBI chr 1:188,577,512...188,685,501
Ensembl chr 1:188,577,575...188,685,504 		JBrowse link
G Fcgr2b Fc gamma receptor 2B increases expression ISO Methylphenidate results in increased expression of FCGR2B mRNA CTD PMID:22470460 NCBI chr13:83,191,253...83,207,778
Ensembl chr13:83,193,163...83,207,778 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
decreases expression		 ISO
EXP		 [Methylphenidate co-treated with SLC6A3 protein] results in increased expression of FOS protein; Methylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA]; Methylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]
Methylphenidate results in increased expression of FOS mRNA; Methylphenidate results in increased expression of FOS protein
SLC6A3 protein affects the reaction [Methylphenidate results in increased expression of FOS protein]
Methylphenidate results in decreased expression of FOS protein
[Fluoxetine co-treated with Methylphenidate] results in increased expression of FOS mRNA; Fluoxetine promotes the reaction [Methylphenidate results in increased expression of FOS mRNA]		 CTD PMID:12112414 PMID:12699766 PMID:15916815 PMID:19931852 PMID:21753012 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression EXP Methylphenidate results in increased expression of FOSB protein CTD PMID:15916815 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Galnt10 polypeptide N-acetylgalactosaminyltransferase 10 decreases expression ISO Methylphenidate results in decreased expression of GALNT10 mRNA CTD PMID:22470460 NCBI chr10:41,821,216...41,967,618
Ensembl chr10:41,820,158...41,967,013 		JBrowse link
G Gch1 GTP cyclohydrolase 1 decreases expression ISO Methylphenidate results in decreased expression of GCH1 mRNA CTD PMID:22470460 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Gdnf glial cell derived neurotrophic factor decreases expression ISO Methylphenidate results in decreased expression of GDNF mRNA CTD PMID:22470460 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Ghdc GH3 domain containing decreases expression ISO Methylphenidate results in decreased expression of GHDC mRNA CTD PMID:22470460 NCBI chr10:85,693,612...85,697,833
Ensembl chr10:85,693,616...85,697,865 		JBrowse link
G Grik3 glutamate ionotropic receptor kainate type subunit 3 decreases expression ISO Methylphenidate results in decreased expression of GRIK3 mRNA CTD PMID:22470460 NCBI chr 5:137,767,865...137,989,617
Ensembl chr 5:137,767,865...137,984,307 		JBrowse link
G Gucy2c guanylate cyclase 2C decreases expression ISO Methylphenidate results in decreased expression of GUCY2C mRNA CTD PMID:22470460 NCBI chr 4:169,568,505...169,649,092
Ensembl chr 4:169,568,529...169,649,092 		JBrowse link
G Hbp1 HMG-box transcription factor 1 decreases expression ISO Methylphenidate results in decreased expression of HBP1 mRNA CTD PMID:22470460 NCBI chr 6:48,529,633...48,555,775
Ensembl chr 6:48,529,372...48,555,787 		JBrowse link
G Hmgb1 high mobility group box 1 increases expression EXP Methylphenidate results in increased expression of HMGB1 mRNA CTD PMID:32746681 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Homer1 homer scaffold protein 1 increases expression
multiple interactions		 EXP Methylphenidate results in increased expression of HOMER1 mRNA
SCH 23390 inhibits the reaction [Methylphenidate results in increased expression of HOMER1 mRNA]		 CTD PMID:16549270 NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785 		JBrowse link
G Hspb6 heat shock protein family B (small) member 6 decreases expression ISO Methylphenidate results in decreased expression of HSPB6 mRNA CTD PMID:22470460 NCBI chr 1:85,806,898...85,809,072
Ensembl chr 1:85,806,146...85,809,071 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A decreases expression EXP Methylphenidate decreases expression of Htr1a mRNA in the nucleus accumbens RGD PMID:30594665 RGD:405866343 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Il1b interleukin 1 beta increases expression EXP Methylphenidate results in increased expression of IL1B mRNA CTD PMID:32746681 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases expression ISO
EXP		 Methylphenidate results in increased expression of IL6 mRNA CTD PMID:22470460 PMID:32746681 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ip6k1 inositol hexakisphosphate kinase 1 increases expression ISO Methylphenidate results in increased expression of IP6K1 mRNA CTD PMID:22470460 NCBI chr 8:108,693,068...108,737,278 JBrowse link
G Jak3 Janus kinase 3 decreases expression ISO Methylphenidate results in decreased expression of JAK3 mRNA CTD PMID:22470460 NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536 		JBrowse link
G Kifc3 kinesin family member C3 decreases expression ISO Methylphenidate results in decreased expression of KIFC3 mRNA CTD PMID:22470460 NCBI chr19:9,825,114...9,920,371
Ensembl chr19:9,886,693...9,920,451 		JBrowse link
G Lad1 ladinin 1 decreases expression ISO Methylphenidate results in decreased expression of LAD1 mRNA CTD PMID:22470460 NCBI chr13:47,249,605...47,263,967
Ensembl chr13:47,249,605...47,263,967 		JBrowse link
G Lama3 laminin subunit alpha 3 decreases expression ISO Methylphenidate results in decreased expression of LAMA3 mRNA CTD PMID:22470460 NCBI chr18:3,523,168...3,751,722
Ensembl chr18:3,523,133...3,751,353 		JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 increases expression EXP Methylphenidate results in increased expression of LAMP2 mRNA CTD PMID:32746681 NCBI chr  X:117,173,097...117,222,090
Ensembl chr  X:117,057,606...117,260,522 		JBrowse link
G Large1 LARGE xylosyl- and glucuronyltransferase 1 decreases expression ISO Methylphenidate results in decreased expression of LARGE1 mRNA CTD PMID:22470460 NCBI chr19:11,603,129...12,048,930
Ensembl chr19:11,603,129...12,048,930 		JBrowse link
G Lasp1 LIM and SH3 protein 1 increases expression ISO Methylphenidate results in increased expression of LASP1 mRNA CTD PMID:22470460 NCBI chr10:82,795,177...82,835,659
Ensembl chr10:82,795,137...82,943,292 		JBrowse link
G Lgals3bp galectin 3 binding protein decreases expression ISO Methylphenidate results in decreased expression of LGALS3BP mRNA CTD PMID:22470460 NCBI chr10:103,619,912...103,629,251
Ensembl chr10:103,619,908...103,629,256 		JBrowse link
G Lhfpl5 LHFPL tetraspan subfamily member 5 decreases expression ISO Methylphenidate results in decreased expression of LHFPL5 mRNA CTD PMID:22470460 NCBI chr20:6,632,324...6,642,534
Ensembl chr20:6,632,362...6,642,532 		JBrowse link
G Lrrc27 leucine rich repeat containing 27 decreases expression ISO Methylphenidate results in decreased expression of LRRC27 mRNA CTD PMID:22470460 NCBI chr 1:194,004,967...194,035,087
Ensembl chr 1:194,005,182...194,035,084 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta decreases expression
increases expression		 ISO
EXP		 Methylphenidate results in decreased expression of MAP1LC3B mRNA
Methylphenidate results in increased expression of MAP1LC3B mRNA		 CTD PMID:22470460 PMID:32746681 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases expression
multiple interactions		 EXP Methylphenidate results in decreased expression of MAPK1 mRNA
[Fluoxetine co-treated with Methylphenidate] results in increased expression of MAPK1 mRNA; [Fluoxetine co-treated with Methylphenidate] results in increased phosphorylation of MAPK1 protein		 CTD PMID:21753012 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases expression ISO Methylphenidate results in increased expression of MAPK8 mRNA CTD PMID:22470460 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mlc1 modulator of VRAC current 1 decreases expression ISO Methylphenidate results in decreased expression of MLC1 mRNA CTD PMID:22470460 NCBI chr 7:120,046,705...120,067,049
Ensembl chr 7:120,046,705...120,067,049 		JBrowse link
G Morn2 MORN repeat containing 2 decreases expression ISO Methylphenidate results in decreased expression of MORN2 mRNA CTD PMID:22470460 NCBI chr 6:14,718,799...14,725,281 JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
affects expression
increases expression		 EXP [Fluoxetine co-treated with Methylphenidate] results in increased expression of MTOR mRNA; [Fluoxetine co-treated with Methylphenidate] results in increased phosphorylation of MTOR protein
Methylphenidate affects the expression of MTOR mRNA
Methylphenidate results in increased expression of MTOR mRNA		 CTD PMID:21753012 PMID:32746681 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Mvp major vault protein decreases expression ISO Methylphenidate results in decreased expression of MVP mRNA CTD PMID:22470460 NCBI chr 1:181,594,734...181,622,336
Ensembl chr 1:181,594,734...181,622,380 		JBrowse link
G Nabp1 nucleic acid binding protein 1 increases expression ISO Methylphenidate results in increased expression of NABP1 mRNA CTD PMID:22470460 NCBI chr 9:50,098,552...50,133,982
Ensembl chr 9:50,126,726...50,134,107 		JBrowse link
G Nacad NAC alpha domain containing decreases expression ISO Methylphenidate results in decreased expression of NACAD mRNA CTD PMID:22470460 NCBI chr14:81,465,299...81,473,866
Ensembl chr14:81,465,299...81,473,781 		JBrowse link
G Ncor2 nuclear receptor co-repressor 2 decreases expression ISO Methylphenidate results in decreased expression of NCOR2 mRNA CTD PMID:22470460 NCBI chr12:31,466,418...31,628,319
Ensembl chr12:31,466,412...31,628,319 		JBrowse link
G Neto2 neuropilin and tolloid like 2 increases expression ISO Methylphenidate results in increased expression of NETO2 mRNA CTD PMID:22470460 NCBI chr19:21,344,299...21,415,524
Ensembl chr19:21,344,289...21,417,023 		JBrowse link
G Nol3 nucleolar protein 3 decreases expression ISO Methylphenidate results in decreased expression of NOL3 mRNA CTD PMID:22470460 NCBI chr19:33,154,061...33,158,250
Ensembl chr19:33,154,062...33,158,250 		JBrowse link
G Nsun4 NOP2/Sun RNA methyltransferase 4 increases expression ISO Methylphenidate results in increased expression of NSUN4 mRNA CTD PMID:22470460 NCBI chr 5:129,511,224...129,532,498
Ensembl chr 5:129,512,307...129,532,423
Ensembl chr 5:129,512,307...129,532,423 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions ISO [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [Methylphenidate inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]] CTD PMID:24394491 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Parp3 poly (ADP-ribose) polymerase family, member 3 increases expression ISO Methylphenidate results in increased expression of PARP3 mRNA CTD PMID:22470460 NCBI chr 8:107,111,010...107,117,073
Ensembl chr 8:107,111,012...107,116,782 		JBrowse link
G Pear1 platelet endothelial aggregation receptor 1 increases expression ISO Methylphenidate results in increased expression of PEAR1 mRNA CTD PMID:22470460 NCBI chr 2:173,206,298...173,234,106
Ensembl chr 2:173,207,664...173,227,440 		JBrowse link
G Peds1 plasmanylethanolamine desaturase 1 decreases expression ISO Methylphenidate results in decreased expression of PEDS1 mRNA CTD PMID:22470460 NCBI chr 3:156,350,135...156,369,309
Ensembl chr 3:156,349,526...156,369,314 		JBrowse link
G Pisd phosphatidylserine decarboxylase decreases expression ISO Methylphenidate results in decreased expression of PISD mRNA CTD PMID:22470460 NCBI chr14:77,941,927...77,991,021
Ensembl chr14:77,941,948...77,991,003 		JBrowse link
G Pkn1 protein kinase N1 decreases expression ISO Methylphenidate results in decreased expression of PKN1 mRNA CTD PMID:22470460 NCBI chr19:24,442,130...24,470,107
Ensembl chr19:24,442,122...24,470,107 		JBrowse link
G Pnma8b PNMA family member 8B increases expression ISO Methylphenidate results in increased expression of PNMA8B mRNA CTD PMID:22470460 NCBI chr 1:77,622,287...77,626,525
Ensembl chr 1:77,622,283...77,627,148 		JBrowse link
G Prkg2 protein kinase cGMP-dependent 2 increases expression ISO Methylphenidate results in increased expression of PRKG2 mRNA CTD PMID:22470460 NCBI chr14:10,559,882...10,668,479
Ensembl chr14:10,559,882...10,666,888 		JBrowse link
G Prlr prolactin receptor decreases expression ISO Methylphenidate results in decreased expression of PRLR mRNA CTD PMID:22470460 NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718 		JBrowse link
G Prpf39 pre-mRNA processing factor 39 increases expression ISO Methylphenidate results in increased expression of PRPF39 mRNA CTD PMID:22470460 NCBI chr 6:83,088,981...83,113,826
Ensembl chr 6:83,088,986...83,113,825 		JBrowse link
G Ptdss2 phosphatidylserine synthase 2 decreases expression ISO Methylphenidate results in decreased expression of PTDSS2 mRNA CTD PMID:22470460 NCBI chr 1:196,241,439...196,267,632
Ensembl chr 1:196,241,494...196,267,685 		JBrowse link
G Ptpn21 protein tyrosine phosphatase, non-receptor type 21 increases expression ISO Methylphenidate results in increased expression of PTPN21 mRNA CTD PMID:22470460 NCBI chr 6:117,933,066...117,998,095
Ensembl chr 6:117,933,066...117,998,095 		JBrowse link
G Pus7l pseudouridine synthase 7 like decreases expression ISO Methylphenidate results in decreased expression of PUS7L mRNA CTD PMID:22470460 NCBI chr 7:125,659,507...125,706,582
Ensembl chr 7:125,659,507...125,682,333 		JBrowse link
G Rab38 RAB38, member RAS oncogene family increases expression ISO Methylphenidate results in increased expression of RAB38 mRNA CTD PMID:22470460 NCBI chr 1:142,182,566...142,262,923
Ensembl chr 1:142,182,556...142,262,924 		JBrowse link
G Racgap1 Rac GTPase-activating protein 1 decreases expression ISO Methylphenidate results in decreased expression of RACGAP1 mRNA CTD PMID:22470460 NCBI chr 7:130,750,936...130,780,891
Ensembl chr 7:130,750,936...130,780,831 		JBrowse link
G Rbfox1 RNA binding fox-1 homolog 1 increases expression ISO Methylphenidate results in increased expression of RBFOX1 mRNA CTD PMID:22470460 NCBI chr10:8,152,198...10,248,120
Ensembl chr10:8,152,198...9,686,659 		JBrowse link
G Rcc2 regulator of chromosome condensation 2 decreases expression ISO Methylphenidate results in decreased expression of RCC2 mRNA CTD PMID:22470460 NCBI chr 5:152,994,406...153,017,223
Ensembl chr 5:152,993,665...153,017,205 		JBrowse link
G Ret ret proto-oncogene decreases expression ISO Methylphenidate results in decreased expression of RET mRNA CTD PMID:22470460 NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176 		JBrowse link
G Rgma repulsive guidance molecule BMP co-receptor a decreases expression ISO Methylphenidate results in decreased expression of RGMA mRNA CTD PMID:22470460 NCBI chr 1:127,128,934...127,172,918
Ensembl chr 1:127,128,934...127,172,918 		JBrowse link
G Rgs20 regulator of G-protein signaling 20 decreases expression ISO Methylphenidate results in decreased expression of RGS20 mRNA CTD PMID:22470460 NCBI chr 5:14,484,436...14,614,317
Ensembl chr 5:14,534,775...14,614,084 		JBrowse link
G Rhbdd2 rhomboid domain containing 2 decreases expression ISO Methylphenidate results in decreased expression of RHBDD2 mRNA CTD PMID:22470460 NCBI chr12:21,043,605...21,054,305
Ensembl chr12:21,043,608...21,054,289 		JBrowse link
G Sdc3 syndecan 3 decreases expression ISO Methylphenidate results in decreased expression of SDC3 mRNA CTD PMID:22470460 NCBI chr 5:142,965,659...142,998,390
Ensembl chr 5:142,965,591...142,996,480 		JBrowse link
G Siae sialic acid acetylesterase decreases expression ISO Methylphenidate results in decreased expression of SIAE mRNA CTD PMID:22470460 NCBI chr 8:37,318,724...37,354,004
Ensembl chr 8:37,318,747...37,353,996 		JBrowse link
G Slc10a4 solute carrier family 10, member 4 decreases expression ISO Methylphenidate results in decreased expression of SLC10A4 mRNA CTD PMID:22470460 NCBI chr14:35,198,149...35,203,863
Ensembl chr14:35,197,886...35,203,729 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 decreases expression
decreases activity		 ISO Methylphenidate results in decreased expression of SLC18A2 mRNA
Methylphenidate results in decreased activity of SLC18A2 protein		 CTD PMID:22470460 PMID:33378168 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325 		JBrowse link
G Slc2a12 solute carrier family 2 member 12 increases expression ISO Methylphenidate results in increased expression of SLC2A12 mRNA CTD PMID:22470460 NCBI chr 1:22,803,068...22,862,204
Ensembl chr 1:22,804,418...22,860,971 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions
affects response to substance
increases response to substance
decreases expression		 ISO [Methylphenidate co-treated with SLC6A3 protein] results in increased expression of FOS protein; [SLC6A3 protein polymorphism affects the susceptibility to Methylphenidate] which affects the uptake of Dopamine; Methylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA]; Methylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]; Methylphenidate inhibits the reaction [SLC6A3 protein mutant form results in increased export of Dopamine]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]
SLC6A3 3' UTR polymorphism affects the susceptibility to Methylphenidate; SLC6A3 protein polymorphism affects the susceptibility to Methylphenidate
SLC6A3 protein affects the reaction [Methylphenidate results in increased expression of FOS protein]
SLC6A3 protein results in increased susceptibility to Methylphenidate
Methylphenidate results in decreased expression of SLC6A3 protein
Methylphenidate results in decreased expression of SLC6A3 mRNA		 CTD PMID:12112414 PMID:12699766 PMID:15059031 PMID:16139732 PMID:17234900 More... NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Snap25 synaptosome associated protein 25 affects response to substance ISO SNAP25 gene polymorphism affects the susceptibility to Methylphenidate CTD PMID:17023870 NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760 		JBrowse link
G Sncaip synuclein, alpha interacting protein increases expression ISO Methylphenidate results in increased expression of SNCAIP mRNA CTD PMID:22470460 NCBI chr18:46,205,846...46,343,932
Ensembl chr18:46,207,152...46,343,929 		JBrowse link
G Sncg synuclein, gamma decreases expression ISO Methylphenidate results in decreased expression of SNCG mRNA CTD PMID:22470460 NCBI chr16:9,700,513...9,705,751
Ensembl chr16:9,700,514...9,705,368 		JBrowse link
G Snx22 sorting nexin 22 decreases expression ISO Methylphenidate results in decreased expression of SNX22 mRNA CTD PMID:22470460 NCBI chr 8:66,609,914...66,612,932
Ensembl chr 8:66,609,970...66,612,850 		JBrowse link
G Sorcs3 sortilin-related VPS10 domain containing receptor 3 decreases expression ISO Methylphenidate results in decreased expression of SORCS3 mRNA CTD PMID:22470460 NCBI chr 1:247,099,178...247,734,027
Ensembl chr 1:247,099,408...247,734,027 		JBrowse link
G Sox11 SRY-box transcription factor 11 increases expression ISO Methylphenidate results in increased expression of SOX11 mRNA CTD PMID:22470460 NCBI chr 6:44,008,333...44,010,354
Ensembl chr 6:44,008,340...44,010,354 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A decreases expression ISO Methylphenidate results in decreased expression of STAT5A mRNA CTD PMID:22470460 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866 		JBrowse link
G Stox2 storkhead box 2 increases expression ISO Methylphenidate results in increased expression of STOX2 mRNA CTD PMID:22470460 NCBI chr16:44,848,179...45,087,238
Ensembl chr16:44,848,078...45,085,105 		JBrowse link
G Suds3 SDS3 homolog, SIN3A corepressor complex component decreases expression ISO Methylphenidate results in decreased expression of SUDS3 mRNA CTD PMID:22470460 NCBI chr12:39,477,181...39,499,633
Ensembl chr12:39,477,568...39,499,628 		JBrowse link
G Taar1 trace-amine-associated receptor 1 multiple interactions ISO Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]] CTD PMID:17234900 NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084 		JBrowse link
G Th tyrosine hydroxylase decreases expression ISO Methylphenidate results in decreased expression of TH mRNA CTD PMID:22470460 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Tmem185b transmembrane protein 185B decreases expression ISO Methylphenidate results in decreased expression of TMEM185B mRNA CTD PMID:22470460 NCBI chr13:30,647,533...30,650,864
Ensembl chr13:30,647,482...30,650,858 		JBrowse link
G Tmem30a transmembrane protein 30A decreases expression ISO Methylphenidate results in decreased expression of TMEM30A mRNA CTD PMID:22470460 NCBI chr 8:80,728,749...80,757,197
Ensembl chr 8:80,729,619...80,753,248 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO Methylphenidate results in increased expression of TNF mRNA CTD PMID:22470460 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Traf5 TNF receptor-associated factor 5 decreases expression ISO Methylphenidate results in decreased expression of TRAF5 mRNA CTD PMID:22470460 NCBI chr13:103,569,944...103,618,747
Ensembl chr13:103,572,314...103,618,709 		JBrowse link
G Trim25 tripartite motif-containing 25 increases expression ISO Methylphenidate results in increased expression of TRIM25 mRNA CTD PMID:22470460 NCBI chr10:73,812,818...73,831,271
Ensembl chr10:73,812,818...73,831,257 		JBrowse link
G Tspan17 tetraspanin 17 decreases expression ISO Methylphenidate results in decreased expression of TSPAN17 mRNA CTD PMID:22470460 NCBI chr17:9,819,212...9,826,851
Ensembl chr17:9,819,202...9,826,834 		JBrowse link
G Ttf1 transcription termination factor 1 increases expression ISO Methylphenidate results in increased expression of TTF1 mRNA CTD PMID:22470460 NCBI chr 3:12,384,626...12,409,257
Ensembl chr 3:12,384,655...12,409,257 		JBrowse link
G Twsg1 twisted gastrulation BMP signaling modulator 1 decreases expression ISO Methylphenidate results in decreased expression of TWSG1 mRNA CTD PMID:22470460 NCBI chr 9:105,533,116...105,567,460
Ensembl chr 9:105,533,136...105,567,479 		JBrowse link
G Ube3d ubiquitin protein ligase E3D decreases expression ISO Methylphenidate results in decreased expression of UBE3D mRNA CTD PMID:22470460 NCBI chr 8:87,245,503...87,413,104
Ensembl chr 8:87,245,589...87,413,057 		JBrowse link
G Ubxn10 UBX domain protein 10 decreases expression ISO Methylphenidate results in decreased expression of UBXN10 mRNA CTD PMID:22470460 NCBI chr 5:150,953,772...150,959,608
Ensembl chr 5:150,950,731...150,959,744 		JBrowse link
G Uck2 uridine-cytidine kinase 2 decreases expression ISO Methylphenidate results in decreased expression of UCK2 mRNA CTD PMID:22470460 NCBI chr13:79,380,807...79,438,121
Ensembl chr13:79,383,846...79,438,352 		JBrowse link
G Vash1 vasohibin 1 increases expression ISO Methylphenidate results in increased expression of VASH1 mRNA CTD PMID:22470460 NCBI chr 6:106,330,374...106,345,740
Ensembl chr 6:106,329,123...106,345,726 		JBrowse link
G Wars2 tryptophanyl tRNA synthetase 2 (mitochondrial) decreases expression ISO Methylphenidate results in decreased expression of WARS2 mRNA CTD PMID:22470460 NCBI chr 2:186,459,744...186,543,581
Ensembl chr 2:186,459,444...186,543,571 		JBrowse link
G Zfp14 ZFP14 zinc finger protein decreases expression ISO Methylphenidate results in decreased expression of ZFP14 mRNA CTD PMID:22470460 NCBI chr 1:85,268,649...85,286,125
Ensembl chr 1:85,268,643...85,285,759 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19893
      biological role 19891
        pharmacological role 19122
          neurotransmitter agent 16811
            adrenergic agent 9183
              dexmethylphenidate 141
                methylphenidate 141
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19865
                    main group molecular entity 19865
                      s-block molecular entity 19697
                        hydrogen molecular entity 19678
                          hydrides 19184
                            inorganic hydride 18194
                              pnictogen hydride 18184
                                nitrogen hydride 18096
                                  azane 17900
                                    ammonia 17899
                                      organic amino compound 17899
                                        amino acid 16074
                                          non-proteinogenic amino acid 3992
                                            beta-amino acid 205
                                              beta-amino acid ester 141
                                                methyl phenyl(piperidin-2-yl)acetate 141
                                                  dexmethylphenidate 141
                                                    methylphenidate 141
paths to the root