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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:alverine
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Accession:CHEBI:518413 term browser browse the term
Definition:A tertiary amine having one ethyl and two 3-phenylprop-1-yl groups attached to the nitrogen. An antispasmodic that acts directly on intestinal and uterine smooth muscle, it is used (particularly as the citrate salt) in the treatment of irritable bowel syndrome.
Synonyms:exact_synonym: N-ethyl-3-phenyl-N-(3-phenylpropyl)propan-1-amine
 related_synonym: Bis(gamma-phenylpropyl)ethylamine;   Di(phenylpropyl)ethylamine;   Formula=C20H27N;   InChI=1S/C20H27N/c1-2-21(17-9-15-19-11-5-3-6-12-19)18-10-16-20-13-7-4-8-14-20/h3-8,11-14H,2,9-10,15-18H2,1H3;   InChIKey=ZPFXAOWNKLFJDN-UHFFFAOYSA-N;   N,N-Bis(3-phenylpropyl)ethylamine;   N-Ethyl-3,3'-diphenyldipropylamine;   N-Ethyl-3-phenyl-N-(3-phenylpropyl)-1-propanamine;   N-Ethyl-N-(3-phenylpropyl)benzenepropanamine;   Phenopropamine;   Phenpropamine;   SMILES=CCN(CCCc1ccccc1)CCCc1ccccc1;   alverina;   alverinum
 xref: Beilstein:2856783;   CAS:150-59-4;   DrugBank:DB01616;   Drug_Central:142;   KEGG:D07440;   LINCS:LSM-3988
 xref_mesh: MESH:C010846
 cyclic_relationship: is_conjugate_base_of CHEBI:64320


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alverine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr1a 5-hydroxytryptamine receptor 1A affects binding EXP alverine binds to HTR1A protein CTD PMID:11697552 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO alverine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19883
    role 19833
      application 19505
        refrigerant 17516
          ammonia 17042
            organic amino compound 17041
              amine 7792
                tertiary amine 610
                  alverine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  main group element atom 19771
                    main group molecular entity 19771
                      s-block molecular entity 19520
                        hydrogen molecular entity 19512
                          hydrides 18784
                            inorganic hydride 17511
                              pnictogen hydride 17484
                                nitrogen hydride 17327
                                  azane 17043
                                    ammonia 17042
                                      organic amino compound 17041
                                        tertiary amino compound 8656
                                          tertiary amine 610
                                            alverine 2
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