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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:imidurea
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Accession:CHEBI:51805 term browser browse the term
Definition:An urea that has formula C11H16N8O8.
Synonyms:exact_synonym: N',N'''-methanediylbis{1-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]urea}
 related_synonym: Formula=C11H16N8O8;   Germall 115;   InChI=1S/C11H16N8O8/c20-2-18-4(6(22)16-10(18)26)14-8(24)12-1-13-9(25)15-5-7(23)17-11(27)19(5)3-21/h4-5,20-21H,1-3H2,(H2,12,14,24)(H2,13,15,25)(H,16,22,26)(H,17,23,27);   InChIKey=ZCTXEAQXZGPWFG-UHFFFAOYSA-N;   N,N''-methylenebis(N'-(3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)urea);   SMILES=OCN1C(NC(=O)NCNC(=O)NC2N(CO)C(=O)NC2=O)C(=O)NC1=O;   imidazolidinyl urea;   methanebis(N,N'-(5-ureido-2,4-diketotetrahydroimidazole)-N,N-dimethylol)
 xref: Beilstein:8731946;   CAS:39236-46-9;   LINCS:LSM-5114
 xref_mesh: MESH:C006048
 xref: Patent:US3248285


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imidurea term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c2 aldo-keto reductase family 1, member C2 increases activity ISO imidazolidinyl urea results in increased activity of AKR1C2 promoter CTD PMID:21195160 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO imidazolidinyl urea results in increased expression of ATF3 mRNA CTD PMID:27965148 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Cd80 Cd80 molecule increases expression ISO imidazolidinyl urea results in increased expression of CD80 protein CTD PMID:31958493 NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353
JBrowse link
G Cd86 CD86 molecule increases expression
multiple interactions
ISO imidazolidinyl urea results in increased expression of CD86 protein
Citric Acid inhibits the reaction [imidazolidinyl urea results in increased expression of CD86 protein]; Hydrochloric Acid inhibits the reaction [imidazolidinyl urea results in increased expression of CD86 protein]; Lactic Acid inhibits the reaction [imidazolidinyl urea results in increased expression of CD86 protein]
CTD PMID:29743441 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO imidazolidinyl urea results in increased expression of CXCL2 protein CTD PMID:23178550 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
increases expression
ISO Citric Acid inhibits the reaction [imidazolidinyl urea results in increased expression of ICAM1 protein]; Hydrochloric Acid inhibits the reaction [imidazolidinyl urea results in increased expression of ICAM1 protein]; Lactic Acid inhibits the reaction [imidazolidinyl urea results in increased expression of ICAM1 protein] CTD PMID:29743441 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO imidazolidinyl urea results in increased expression of IL1A protein CTD PMID:23178550 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il2 interleukin 2 increases secretion ISO imidazolidinyl urea results in increased secretion of IL2 protein CTD PMID:22245253 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il6 interleukin 6 increases secretion ISO imidazolidinyl urea results in increased secretion of IL6 protein CTD PMID:22245253 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO imidazolidinyl urea results in increased expression of VEGFA protein CTD PMID:25617811 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        antimicrobial agent 17334
          imidurea 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        carboacyl group 17372
                                          univalent carboacyl group 17372
                                            carbamoyl group 17158
                                              carboxamide 17158
                                                monocarboxylic acid amide 14569
                                                  urea 4989
                                                    ureas 4987
                                                      imidurea 10
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