CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: imipenem hydrate
Accession: CHEBI:51799
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Definition: A carbapenem that has formula C12H19N3O5S.
Synonyms: exact_synonym: (5R,6S)-6-[(1R)-1-hydroxyethyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid--water (1/1)
related_synonym: Formula=C12H19N3O5S; InChI=1S/C12H17N3O4S.H2O/c1-6(16)9-7-4-8(20-3-2-14-5-13)10(12(18)19)15(7)11(9)17;/h5-7,9,16H,2-4H2,1H3,(H2,13,14)(H,18,19);1H2/t6-,7-,9-;/m1./s1; InChIKey=GSOSVVULSKVSLQ-JJVRHELESA-N; N-formimidoyl thienamycin monohydrate; SMILES=[H]O[H].[H]C(=N)NCCSC1=C(N2C(=O)[C@]([H])([C@@H](C)O)[C@@]2([H])C1)C(O)=O; imipenem
xref: Beilstein:8174596; CAS:74431-23-5
xref_mesh: MESH:D015378
xref: Patent:EP6639; Patent:IE48356; Patent:JP55009090; Wikipedia:Imipenem
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Abcb11
ATP binding cassette subfamily B member 11
multiple interactions
ISO
[Vancomycin co-treated with Imipenem] results in increased expression of ABCB11 mRNA
CTD
PMID:24657338
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Abcb1a
ATP binding cassette subfamily B member 1A
multiple interactions
ISO
[Vancomycin co-treated with Imipenem] results in decreased expression of ABCB1A mRNA
CTD
PMID:24657338
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcc2
ATP binding cassette subfamily C member 2
multiple interactions
ISO
[Vancomycin co-treated with Imipenem] affects the expression of ABCC2 mRNA
CTD
PMID:24657338
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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Abcc3
ATP binding cassette subfamily C member 3
multiple interactions
ISO
[Vancomycin co-treated with Imipenem] results in decreased expression of ABCC3 mRNA
CTD
PMID:24657338
NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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Abcg5
ATP binding cassette subfamily G member 5
multiple interactions
ISO
[Vancomycin co-treated with Imipenem] affects the expression of ABCG5 mRNA
CTD
PMID:24657338
NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
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Abcg8
ATP binding cassette subfamily G member 8
multiple interactions
ISO
[Vancomycin co-treated with Imipenem] affects the expression of ABCG8 mRNA
CTD
PMID:24657338
NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912
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Baat
bile acid CoA:amino acid N-acyltransferase
multiple interactions
ISO
[Vancomycin co-treated with Imipenem] results in decreased expression of BAAT mRNA
CTD
PMID:24657338
NCBI chr 5:63,851,668...63,860,641
Ensembl chr 5:63,850,705...63,860,685
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Cyp7a1
cytochrome P450 family 7 subfamily A member 1
multiple interactions
ISO
[Vancomycin co-treated with Imipenem] results in decreased expression of CYP7A1 mRNA
CTD
PMID:24657338
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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Cyp8b1
cytochrome P450 family 8 subfamily B member 1
multiple interactions
ISO
[Vancomycin co-treated with Imipenem] results in decreased expression of CYP8B1 mRNA
CTD
PMID:24657338
NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
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Npc1l1
NPC1 like intracellular cholesterol transporter 1
multiple interactions
ISO
[Vancomycin co-treated with Imipenem] results in decreased expression of NPC1L1 mRNA
CTD
PMID:24657338
NCBI chr14:81,071,448...81,091,113
Ensembl chr14:81,071,451...81,091,113
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Nr0b2
nuclear receptor subfamily 0, group B, member 2
multiple interactions
ISO
[Vancomycin co-treated with Imipenem] results in increased expression of NR0B2 mRNA
CTD
PMID:24657338
NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases activity
ISO
Imipenem results in increased activity of NR1I2 protein
CTD
PMID:25455453
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Nr5a2
nuclear receptor subfamily 5, group A, member 2
multiple interactions
ISO
[Vancomycin co-treated with Imipenem] results in increased expression of NR5A2 mRNA
CTD
PMID:24657338
NCBI chr13:48,313,634...48,433,494
Ensembl chr13:48,316,301...48,433,326
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Slc10a1
solute carrier family 10 member 1
multiple interactions
ISO
[Vancomycin co-treated with Imipenem] results in increased expression of SLC10A1 mRNA
CTD
PMID:24657338
NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
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Slc27a5
solute carrier family 27 member 5
multiple interactions
ISO
[Vancomycin co-treated with Imipenem] results in increased expression of SLC27A5 mRNA
CTD
PMID:24657338
NCBI chr 1:73,616,556...73,627,149
Ensembl chr 1:73,616,564...73,627,172
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Slc51a
solute carrier family 51 member A
multiple interactions
ISO
[Vancomycin co-treated with Imipenem] results in decreased expression of SLC51A mRNA
CTD
PMID:24657338
NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485
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Slco1a4
solute carrier organic anion transporter family, member 1a4
multiple interactions
ISO
[Vancomycin co-treated with Imipenem] results in decreased expression of SLCO1A4 mRNA
CTD
PMID:24657338
NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
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Slco1b2
solute carrier organic anion transporter family member 1B2
multiple interactions
ISO
[Vancomycin co-treated with Imipenem] results in increased expression of SLCO1B2 mRNA
CTD
PMID:24657338
NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
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Slco2b1
solute carrier organic anion transporter family, member 2b1
multiple interactions
ISO
[Vancomycin co-treated with Imipenem] results in increased expression of SLCO2B1 mRNA
CTD
PMID:24657338
NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353
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