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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ynone
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Accession:CHEBI:51723 term browser browse the term
Definition:An alpha,beta-unsaturated ketone of general formula R(1)C#C-C(=O)R(2) (R(2) =/= H) in which the aldehydic C=O function is conjugated to a C#C triple bond at the alpha,beta position.
Synonyms:related_synonym: Formula=C3OR2;   SMILES=[*]C#CC([*])=O;   ynones



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acalabrutinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crp C-reactive protein affects expression ISO acalabrutinib affects the expression of CRP protein CTD PMID:32503877 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing
affects metabolic processing
multiple interactions
ISO CYP3A4 protein results in increased metabolism of acalabrutinib
CYP3A4 protein alternative form affects the metabolism of acalabrutinib
Ketoconazole affects the reaction [CYP3A4 protein alternative form affects the metabolism of acalabrutinib]
CTD PMID:34153224 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Il6 interleukin 6 decreases expression ISO acalabrutinib results in decreased expression of IL6 protein CTD PMID:32503877 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19860
    chemical entity 19858
      group 19816
        polyatomic entity 19815
          molecule 19707
            organic molecule 19692
              acetylenic compound 5886
                ynone 3
                  10,13-Dimethyl-11-docosyne-10,13-diol 0
                  4-phenylbut-3-yn-2-one 0
                  Dehydrofalcarinone 0
                  Dehydrolinalool 0
                  Falcarinone 0
                  Speciosin C 0
                  Speciosin D 0
                  Speciosin E 0
                  Speciosin F 0
                  Speciosin L 0
                  Speciosin M 0
                  Speciosin N 0
                  Speciosin O 0
                  Speciosin U 0
                  Stagonosporyne F 0
                  Truncateol N 0
                  acalabrutinib 3
                  capillin 0
                  methylpentynol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19860
    subatomic particle 19858
      composite particle 19858
        hadron 19858
          baryon 19858
            nucleon 19858
              atomic nucleus 19858
                atom 19858
                  main group element atom 19804
                    p-block element atom 19804
                      carbon group element atom 19745
                        carbon atom 19741
                          organic molecular entity 19741
                            heteroorganic entity 19494
                              organochalcogen compound 19257
                                organooxygen compound 19173
                                  carbonyl compound 18897
                                    ketone 17186
                                      alpha,beta-unsaturated ketone 9976
                                        ynone 3
                                          10,13-Dimethyl-11-docosyne-10,13-diol 0
                                          4-phenylbut-3-yn-2-one 0
                                          Dehydrofalcarinone 0
                                          Dehydrolinalool 0
                                          Falcarinone 0
                                          Speciosin C 0
                                          Speciosin D 0
                                          Speciosin E 0
                                          Speciosin F 0
                                          Speciosin L 0
                                          Speciosin M 0
                                          Speciosin N 0
                                          Speciosin O 0
                                          Speciosin U 0
                                          Stagonosporyne F 0
                                          Truncateol N 0
                                          acalabrutinib 3
                                          capillin 0
                                          methylpentynol 0
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