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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:enoate ester
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Accession:CHEBI:51702 term browser browse the term
Definition:An alpha,beta-unsaturated carboxylic ester of general formula R(1)R(2)C=CR(3)-C(=O)OR(4) (R(4) =/= H) in which the ester C=O function is conjugated to a C=C double bond at the alpha,beta position.
Synonyms:related_synonym: Formula=C3O2R4;   SMILES=[*]\\C([*])=C(\\[*])C(=O)O[*];   enoate;   enoate esters;   enoates


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2-Ethylhexyl acrylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf3 activating transcription factor 3 increases expression ISO 2-ethylhexyl acrylate results in increased expression of ATF3 mRNA CTD PMID:27965148 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO 2-ethylhexyl acrylate results in decreased activity of DIO1 protein CTD PMID:30561685 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Dio2 iodothyronine deiodinase 2 decreases activity ISO 2-ethylhexyl acrylate results in decreased activity of DIO2 protein CTD PMID:30561685 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Dio3 iodothyronine deiodinase 3 decreases activity ISO 2-ethylhexyl acrylate results in decreased activity of DIO3 protein CTD PMID:30561685 NCBI chr 6:134,627,278...134,629,139
Ensembl chr 6:134,627,278...134,629,138
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO 2-ethylhexyl acrylate results in increased expression of DNAJB4 mRNA CTD PMID:27965148 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO 2-ethylhexyl acrylate results in increased expression of GCLM mRNA CTD PMID:27965148 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO 2-ethylhexyl acrylate binds to and results in increased activity of PPARG protein CTD PMID:27633901 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
2-hydroxyethyl methacrylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin increases expression ISO hydroxyethyl methacrylate results in increased expression of ADM mRNA CTD PMID:30497689 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO hydroxyethyl methacrylate results in increased expression of AKR1C2 mRNA CTD PMID:30497689 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases expression ISO hydroxyethyl methacrylate results in increased expression of AKR1C3 mRNA CTD PMID:30497689 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 increases expression ISO hydroxyethyl methacrylate results in increased expression of ALDH3A2 mRNA CTD PMID:30497689 NCBI chr10:47,525,486...47,546,535
Ensembl chr10:47,525,493...47,546,345
JBrowse link
G Atg5 autophagy related 5 increases expression
multiple interactions
ISO hydroxyethyl methacrylate results in increased expression of ATG5 protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased expression of ATG5 protein]; 3-methyladenine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of ATG5 protein]; Chloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of ATG5 protein]
CTD PMID:28184909 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions
ISO hydroxyethyl methacrylate results in increased expression of BECN1 mRNA; hydroxyethyl methacrylate results in increased expression of BECN1 protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of BECN1 protein]; Chloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of BECN1 protein]
CTD PMID:28184909 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
ISO 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased expression of CASP9 mRNA]; 3-methyladenine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of CASP9 mRNA]; Chloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of CASP9 mRNA] CTD PMID:28184909 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO hydroxyethyl methacrylate results in decreased expression of COL1A1 mRNA; hydroxyethyl methacrylate results in decreased expression of COL1A1 protein CTD PMID:20668299 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO hydroxyethyl methacrylate results in decreased expression of CXCL12 protein CTD PMID:30517439 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO hydroxyethyl methacrylate results in increased expression of DNAJB4 mRNA CTD PMID:30497689 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242
JBrowse link
G Fbxo30 F-box protein 30 increases expression ISO hydroxyethyl methacrylate results in increased expression of FBXO30 mRNA CTD PMID:30497689 NCBI chr 1:5,366,119...5,389,774
Ensembl chr 1:5,366,379...5,388,069
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
increases secretion
ISO Acetylcysteine inhibits the reaction [hydroxyethyl methacrylate results in increased secretion of FGF2 protein]; pyrazolanthrone inhibits the reaction [hydroxyethyl methacrylate results in increased secretion of FGF2 protein] CTD PMID:19176594 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fth1 ferritin heavy chain 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of FTH1 mRNA CTD PMID:30497689 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO hydroxyethyl methacrylate results in increased expression of GCLC mRNA; hydroxyethyl methacrylate results in increased expression of GCLC protein CTD PMID:30497689 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO hydroxyethyl methacrylate results in increased expression of GCLM mRNA; hydroxyethyl methacrylate results in increased expression of GCLM protein CTD PMID:30497689 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of HMOX1 mRNA; hydroxyethyl methacrylate results in increased expression of HMOX1 protein CTD PMID:30497689 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO hydroxyethyl methacrylate results in increased expression of HSPA1A mRNA CTD PMID:30497689 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO hydroxyethyl methacrylate results in increased expression of HSPA1B mRNA CTD PMID:30497689 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 2-oxothiazolidine-4-carboxylic acid inhibits the reaction [hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; Buthionine Sulfoximine promotes the reaction [hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; hydroxyethyl methacrylate promotes the reaction [triethylene glycol dimethacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; triethylene glycol dimethacrylate promotes the reaction [hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]] CTD PMID:23182953, PMID:28188892 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 decreases secretion ISO hydroxyethyl methacrylate results in decreased secretion of IL6 protein CTD PMID:19176594 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression
multiple interactions
ISO hydroxyethyl methacrylate results in increased expression of MAP1LC3B mRNA; hydroxyethyl methacrylate results in increased expression of MAP1LC3B protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased expression of MAP1LC3B mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased expression of MAP1LC3B protein]
CTD PMID:28184909 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Map3k14 mitogen-activated protein kinase kinase kinase 14 increases expression ISO hydroxyethyl methacrylate results in increased expression of MAP3K14 mRNA CTD PMID:30497689 NCBI chr10:91,303,428...91,353,601
Ensembl chr10:91,303,428...91,353,601
JBrowse link
G Mrpl19 mitochondrial ribosomal protein L19 increases expression ISO hydroxyethyl methacrylate results in increased expression of MRPL19 mRNA CTD PMID:30497689 NCBI chr 4:112,703,041...112,707,270
Ensembl chr 4:112,703,041...112,707,270
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression ISO hydroxyethyl methacrylate results in increased expression of NFE2L2 protein CTD PMID:30497689 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha increases response to substance
multiple interactions
ISO NFKBIA protein results in increased susceptibility to hydroxyethyl methacrylate
NFKBIA protein affects the reaction [Acetylcysteine results in decreased susceptibility to hydroxyethyl methacrylate]
CTD PMID:19176594 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of NQO1 mRNA; hydroxyethyl methacrylate results in increased expression of NQO1 protein CTD PMID:30497689 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of OSGIN1 mRNA CTD PMID:30497689 NCBI chr19:52,056,808...52,085,491
Ensembl chr19:52,077,109...52,085,496
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased cleavage of PARP1 protein] CTD PMID:28184909 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Acetylcysteine inhibits the reaction [hydroxyethyl methacrylate affects the localization of and results in decreased activity of RELA protein]; hydroxyethyl methacrylate affects the localization of and results in decreased activity of RELA protein; hydroxyethyl methacrylate affects the localization of and results in increased phosphorylation of and results in increased activity of RELA protein; hydroxyethyl methacrylate inhibits the reaction [TNF protein results in increased activity of RELA protein] CTD PMID:19176594, PMID:28184909 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Spsb1 splA/ryanodine receptor domain and SOCS box containing 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of SPSB1 mRNA CTD PMID:30497689 NCBI chr 5:166,913,734...166,978,534
Ensembl chr 5:166,913,735...166,926,636
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of SQSTM1 mRNA; hydroxyethyl methacrylate results in increased expression of SQSTM1 protein CTD PMID:30497689 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of SRXN1 mRNA CTD PMID:30497689 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO hydroxyethyl methacrylate inhibits the reaction [TNF protein results in increased activity of RELA protein]
hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; hydroxyethyl methacrylate promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD PMID:19176594, PMID:23182953, PMID:28188892 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of TXNRD1 mRNA CTD PMID:30497689 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase increases expression ISO hydroxyethyl methacrylate results in increased expression of UGDH mRNA CTD PMID:30497689 NCBI chr14:44,479,614...44,502,845
Ensembl chr14:44,479,614...44,502,845
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases secretion
ISO Acetylcysteine inhibits the reaction [hydroxyethyl methacrylate results in decreased secretion of VEGFA protein]; pyrazolanthrone inhibits the reaction [hydroxyethyl methacrylate results in decreased secretion of VEGFA protein] CTD PMID:19176594 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
acteoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions
decreases localization
ISO acteoside promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased localization of AHR protein]
acteoside results in decreased localization of AHR protein
CTD PMID:21756928 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator increases localization ISO acteoside results in increased localization of ARNT protein CTD PMID:21756928 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions
decreases secretion
ISO acteoside results in decreased expression of CCL2 mRNA
acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]
acteoside results in decreased secretion of CCL2 protein
CTD PMID:21756928, PMID:21967610 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO acteoside results in decreased expression of CCND1 protein CTD PMID:17634406 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO acteoside results in decreased expression of CCND2 protein CTD PMID:17634406 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO acteoside results in decreased expression of CCND3 protein CTD PMID:17634406 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO acteoside results in decreased expression of CCNE1 protein CTD PMID:17634406 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO acteoside results in decreased expression of and results in decreased activity of CDK2 protein CTD PMID:17634406 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases activity
multiple interactions
ISO acteoside results in decreased activity of CDK4 protein
acteoside promotes the reaction [CDKN1A protein binds to CDK4 protein]; acteoside promotes the reaction [CDKN1B protein binds to CDK4 protein]
CTD PMID:17634406 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions ISO acteoside promotes the reaction [CDKN1A protein binds to CDK6 protein]; acteoside promotes the reaction [CDKN1B protein binds to CDK6 protein]; acteoside results in decreased expression of and results in decreased activity of CDK6 protein CTD PMID:17634406 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO acteoside results in increased expression of CDKN1A mRNA; acteoside results in increased expression of CDKN1A protein
acteoside promotes the reaction [CDKN1A protein binds to CDK4 protein]; acteoside promotes the reaction [CDKN1A protein binds to CDK6 protein]
CTD PMID:17634406 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression
multiple interactions
ISO acteoside results in increased expression of CDKN1B mRNA; acteoside results in increased expression of CDKN1B protein
acteoside promotes the reaction [CDKN1B protein binds to CDK4 protein]; acteoside promotes the reaction [CDKN1B protein binds to CDK6 protein]
CTD PMID:17634406 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases secretion
decreases expression
multiple interactions
ISO acteoside results in decreased secretion of CXCL10 protein
acteoside results in decreased expression of CXCL10 mRNA
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; acteoside inhibits the reaction [PD168393 results in increased secretion of CXCL10 protein]; acteoside promotes the reaction [leptomycin B results in decreased secretion of CXCL10 protein]
CTD PMID:21756928, PMID:21967610 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO acteoside results in increased expression of CYP1A1 mRNA CTD PMID:21756928 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP acteoside inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased activity of CYP2E1 protein] CTD PMID:14672760 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO [acteoside results in decreased phosphorylation of RB1 protein] promotes the reaction [RB1 protein binds to E2F1 protein] CTD PMID:17634406 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G Egfr epidermal growth factor receptor decreases phosphorylation
multiple interactions
ISO acteoside results in decreased phosphorylation of EGFR protein
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein]; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein modified form]; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein]
CTD PMID:21756928, PMID:21967610 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO acteoside results in decreased expression of ICAM1 mRNA CTD PMID:21371465 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma decreases expression
multiple interactions
ISO acteoside results in decreased expression of IFNG mRNA
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein]
CTD PMID:21371465, PMID:21756928 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
ISO acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]
acteoside results in decreased expression of IL6 mRNA
CTD PMID:21756928 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions ISO acteoside inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein]; acteoside inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB2 protein] CTD PMID:16393473 NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
decreases phosphorylation
ISO acteoside results in increased phosphorylation of MAPK1 protein
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]
acteoside results in decreased phosphorylation of MAPK1 protein
CTD PMID:21756928, PMID:23527233 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions
increases phosphorylation
ISO acteoside results in decreased phosphorylation of MAPK3 protein
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]
acteoside results in increased phosphorylation of MAPK3 protein
CTD PMID:21756928, PMID:23527233 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nox1 NADPH oxidase 1 decreases activity ISO acteoside results in decreased activity of NOX1 protein CTD PMID:16393473 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Ptgds prostaglandin D2 synthase affects binding ISO acteoside binds to PTGDS protein CTD PMID:26456343 NCBI chr 3:2,686,125...2,689,059
Ensembl chr 3:2,686,123...2,689,084
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [acteoside co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PTGS2 mRNA CTD PMID:21756928 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation
multiple interactions
ISO acteoside results in decreased phosphorylation of RB1 protein
[acteoside results in decreased phosphorylation of RB1 protein] promotes the reaction [RB1 protein binds to E2F1 protein]
CTD PMID:17634406 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases phosphorylation
multiple interactions
decreases phosphorylation
ISO acteoside results in increased phosphorylation of RELA protein
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein]
acteoside results in decreased phosphorylation of RELA protein
CTD PMID:21756928, PMID:23527233 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Smad2 SMAD family member 2 increases phosphorylation ISO acteoside results in increased phosphorylation of SMAD2 protein CTD PMID:17634406 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Smad3 SMAD family member 3 increases phosphorylation ISO acteoside results in increased phosphorylation of SMAD3 protein CTD PMID:17634406 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Sod2 superoxide dismutase 2 decreases expression ISO acteoside results in decreased expression of SOD2 mRNA CTD PMID:21371465 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO [acteoside co-treated with TGFA protein] results in increased expression of CXCL8 mRNA; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein modified form]; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein] CTD PMID:21756928, PMID:21967610 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO acteoside results in increased expression of TGFB1 mRNA CTD PMID:17634406 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein] CTD PMID:21756928 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression ISO acteoside results in decreased expression of VCAM1 mRNA CTD PMID:21371465 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
arecoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions
increases expression
ISO U 0126 inhibits the reaction [Arecoline results in increased expression of ACTA2 protein]
Arecoline results in increased expression of ACTA2 mRNA; Arecoline results in increased expression of ACTA2 protein
CTD PMID:32441858 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor multiple interactions ISO Arecoline inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHRR mRNA] CTD PMID:17234337 NCBI chr 1:31,603,297...31,698,329
Ensembl chr 1:31,603,297...31,698,329
JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 decreases expression ISO Arecoline results in decreased expression of AKR1A1 mRNA CTD PMID:17682004 NCBI chr 5:135,482,068...135,498,693
Ensembl chr 5:135,482,068...135,498,822
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [arecoline hydrobromide results in increased abundance of Arecoline] inhibits the reaction [2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester results in decreased phosphorylation of AKT1 protein]; [arecoline hydrobromide results in increased abundance of Arecoline] which results in decreased phosphorylation of AKT1 protein; PHLPP2 protein affects the reaction [[arecoline hydrobromide results in increased abundance of Arecoline] which results in decreased phosphorylation of AKT1 protein] CTD PMID:30910432 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Aldh9a1 aldehyde dehydrogenase 9 family, member A1 decreases expression ISO Arecoline results in decreased expression of ALDH9A1 mRNA CTD PMID:17682004 NCBI chr13:85,580,828...85,597,497
Ensembl chr13:85,580,828...85,597,493
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 decreases expression ISO Arecoline results in decreased expression of APEX1 mRNA CTD PMID:17682004 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Ar androgen receptor increases expression EXP Arecoline results in increased expression of AR mRNA; Arecoline results in increased expression of AR protein CTD PMID:21741983 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Arecoline results in decreased expression of BCL2 protein CTD PMID:22108589 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression ISO Arecoline results in decreased expression of BRCA1 mRNA CTD PMID:17682004 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Casp3 caspase 3 increases activity ISO Arecoline results in increased activity of CASP3 protein CTD PMID:22108589 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase decreases expression EXP Arecoline analog results in decreased expression of CAT CTD PMID:25056785 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases secretion ISO Arecoline results in increased secretion of CCL5 protein CTD PMID:21297082 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions
EXP
ISO
Arecoline results in increased expression of CCND1 mRNA; Arecoline results in increased expression of CCND1 protein
[arecoline hydrobromide results in increased abundance of Arecoline] inhibits the reaction [2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester results in decreased expression of CCND1 protein]; [arecoline hydrobromide results in increased abundance of Arecoline] which results in decreased expression of CCND1 protein
CTD PMID:21741983, PMID:30910432 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnh cyclin H decreases expression ISO Arecoline results in decreased expression of CCNH mRNA CTD PMID:17682004 NCBI chr 2:13,593,100...13,613,910
Ensembl chr 2:13,593,100...13,613,910
JBrowse link
G Cdc25c cell division cycle 25C multiple interactions
decreases expression
ISO [[Arecoline results in decreased expression of CDC25C] co-treated with [Arecoline results in increased expression of TP53]] results in decreased activity of CDK1 protein
Arecoline results in decreased expression of CDC25C protein
CTD PMID:22108589 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdh1 cadherin 1 multiple interactions
decreases expression
ISO U 0126 inhibits the reaction [Arecoline results in decreased expression of CDH1 protein] CTD PMID:32441858 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh2 cadherin 2 increases expression ISO Arecoline results in increased expression of CDH2 protein CTD PMID:32441858 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases activity
multiple interactions
ISO Arecoline results in decreased activity of CDK1 protein
[[Arecoline results in decreased expression of CDC25C] co-treated with [Arecoline results in increased expression of TP53]] results in decreased activity of CDK1 protein
CTD PMID:22108589 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression EXP Arecoline results in increased expression of CDK4 mRNA; Arecoline results in increased expression of CDK4 protein CTD PMID:21741983 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Chaf1a chromatin assembly factor 1 subunit A decreases expression ISO Arecoline results in decreased expression of CHAF1A mRNA CTD PMID:17682004 NCBI chr 9:11,000,869...11,027,631
Ensembl chr 9:11,001,129...11,027,506
JBrowse link
G Chaf1b chromatin assembly factor 1 subunit B decreases expression ISO Arecoline results in decreased expression of CHAF1B mRNA CTD PMID:17682004 NCBI chr11:34,101,248...34,121,371
Ensembl chr11:34,101,197...34,121,378
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 affects binding
multiple interactions
ISO CHRM3 protein binds to Arecoline
brucine promotes the reaction [Arecoline binds to CHRM3 protein]
CTD PMID:9224827 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Col4a6 collagen type IV alpha 6 chain increases expression ISO Arecoline results in increased expression of COL4A6 protein CTD PMID:32441858 NCBI chr  X:112,405,647...112,768,337
Ensembl chr  X:112,405,647...112,473,822
JBrowse link
G Cryab crystallin, alpha B multiple interactions ISO [4-Nitroquinoline-1-oxide co-treated with Arecoline] results in increased expression of CRYAB protein CTD PMID:19840781 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO [Arecoline co-treated with 4-nitroquinolone-1-oxide] results in increased expression of CTNNB1 protein CTD PMID:26464283 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Arecoline inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Arecoline inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:17234337, PMID:17707585 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity EXP Arecoline analog results in increased activity of CYP1A2 protein CTD PMID:25056785 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 decreases expression ISO Arecoline results in decreased expression of CYP26B1 mRNA CTD PMID:17682004 NCBI chr 4:116,261,796...116,278,615
Ensembl chr 4:116,261,796...116,278,615
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases activity EXP Arecoline analog results in increased activity of CYP2E1 protein CTD PMID:25056785 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Dclre1b DNA cross-link repair 1B decreases expression ISO Arecoline results in decreased expression of DCLRE1B mRNA CTD PMID:17682004 NCBI chr 2:206,285,085...206,293,599
Ensembl chr 2:206,285,089...206,293,599
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO Arecoline results in increased expression of DDIT4 mRNA CTD PMID:17682004 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 increases expression ISO Arecoline results in increased expression of DNAJA1 mRNA CTD PMID:17682004 NCBI chr 5:57,028,467...57,039,378
Ensembl chr 5:57,028,467...57,039,378
JBrowse link
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 decreases expression ISO Arecoline results in decreased expression of EEF1E1 mRNA CTD PMID:17682004 NCBI chr17:26,785,017...26,795,723
Ensembl chr17:26,785,029...26,797,161
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO [Arecoline co-treated with 4-nitroquinolone-1-oxide] results in increased phosphorylation of EGFR protein; [helioxanthin co-treated with Arecoline co-treated with 4-nitroquinolone-1-oxide] affects the localization of EGFR protein modified form; helioxanthin inhibits the reaction [[Arecoline co-treated with 4-nitroquinolone-1-oxide] results in increased phosphorylation of EGFR protein] CTD PMID:26464283 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO [arecoline hydrobromide results in increased abundance of Arecoline] which results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:30910432 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit decreases expression ISO Arecoline results in decreased expression of ERCC2 mRNA CTD PMID:17682004 NCBI chr 1:80,293,574...80,307,334
Ensembl chr 1:80,293,566...80,307,344
JBrowse link
G Fancg FA complementation group G decreases expression ISO Arecoline results in decreased expression of FANCG mRNA CTD PMID:17682004 NCBI chr 5:58,448,060...58,456,416
Ensembl chr 5:58,448,822...58,455,819
JBrowse link
G Fn1 fibronectin 1 increases expression ISO Arecoline results in increased expression of FN1 protein CTD PMID:26908192 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [helioxanthin co-treated with Arecoline co-treated with 4-nitroquinolone-1-oxide] affects the expression of FOS protein; [helioxanthin co-treated with Arecoline co-treated with 4-nitroquinolone-1-oxide] affects the localization of FOS protein CTD PMID:26464283 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fshb follicle stimulating hormone subunit beta increases expression EXP Arecoline results in increased expression of FSHB protein CTD PMID:21741983 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Arecoline results in increased expression of GDF15 mRNA CTD PMID:17682004 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gss glutathione synthetase decreases expression ISO Arecoline results in decreased expression of GSS mRNA CTD PMID:17682004 NCBI chr 3:151,076,254...151,106,557
Ensembl chr 3:151,076,254...151,106,557
JBrowse link
G Gtf2h5 general transcription factor IIH subunit 5 decreases expression ISO Arecoline results in decreased expression of GTF2H5 mRNA CTD PMID:17682004 NCBI chr 1:46,978,345...46,985,032
Ensembl chr 1:46,978,458...46,985,032
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions ISO [4-Nitroquinoline-1-oxide co-treated with Arecoline] results in increased expression of HSPB1 protein CTD PMID:19840781 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Il6 interleukin 6 decreases secretion
decreases expression
ISO Arecoline results in decreased secretion of IL6 protein
Arecoline results in decreased expression of IL6 mRNA
CTD PMID:22108589 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Lcmt1 leucine carboxyl methyltransferase 1 decreases expression ISO Arecoline results in decreased expression of LCMT1 mRNA CTD PMID:17682004 NCBI chr 1:193,335,629...193,391,620
Ensembl chr 1:193,335,645...193,391,638
JBrowse link
G Lhb luteinizing hormone subunit beta increases expression EXP Arecoline results in increased expression of LHB protein CTD PMID:21741983 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Maoa monoamine oxidase A decreases expression ISO Arecoline results in decreased expression of MAOA mRNA CTD PMID:17682004 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO [helioxanthin co-treated with Arecoline co-treated with 4-nitroquinolone-1-oxide] affects the phosphorylation of MAPK1 protein; Dinoprostone affects the reaction [[helioxanthin co-treated with Arecoline co-treated with 4-nitroquinolone-1-oxide] affects the phosphorylation of MAPK1 protein]
Arecoline results in increased phosphorylation of MAPK1 protein
U 0126 inhibits the reaction [Arecoline results in increased phosphorylation of MAPK1 protein]
CTD PMID:26464283, PMID:32441858 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO [helioxanthin co-treated with Arecoline co-treated with 4-nitroquinolone-1-oxide] affects the phosphorylation of MAPK3 protein; Dinoprostone affects the reaction [[helioxanthin co-treated with Arecoline co-treated with 4-nitroquinolone-1-oxide] affects the phosphorylation of MAPK3 protein]
U 0126 inhibits the reaction [Arecoline results in increased phosphorylation of MAPK3 protein]
CTD PMID:26464283, PMID:32441858 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mir136 microRNA 136 increases expression ISO Arecoline results in increased expression of MIR136 CTD PMID:21750350 NCBI chr 6:133,716,761...133,716,842
Ensembl chr 6:133,716,761...133,716,842
JBrowse link
G Mir143 microRNA 143 increases expression ISO Arecoline results in increased expression of MIR143 CTD PMID:21750350 NCBI chr18:56,971,273...56,971,377
Ensembl chr18:56,971,273...56,971,377
JBrowse link
G Mir145 microRNA 145 increases expression ISO Arecoline results in increased expression of MIR145 CTD PMID:21750350 NCBI chr18:56,969,907...56,969,994
Ensembl chr18:56,969,907...56,969,994
JBrowse link
G Mir23a microRNA 23a increases expression ISO Arecoline results in increased expression of MIR23A CTD PMID:21750350 NCBI chr19:25,318,582...25,318,656
Ensembl chr19:25,318,582...25,318,656
JBrowse link
G Mir26a microRNA 26a increases expression ISO Arecoline results in increased expression of MIR26A1 CTD PMID:21750350 NCBI chr 8:127,714,441...127,714,530
Ensembl chr 8:127,714,441...127,714,530
JBrowse link
G Mir26b microRNA 26b increases expression ISO Arecoline results in increased expression of MIR26B CTD PMID:21750350 NCBI chr 9:81,675,275...81,675,359
Ensembl chr 9:81,675,275...81,675,359
JBrowse link
G Mir30a microRNA 30a increases expression ISO Arecoline results in increased expression of MIR30A CTD PMID:21750350 NCBI chr 9:29,542,635...29,542,705
Ensembl chr 9:29,542,635...29,542,705
JBrowse link
G Mlh1 mutL homolog 1 decreases expression ISO Arecoline results in decreased expression of MLH1 mRNA CTD PMID:17682004 NCBI chr 8:119,486,655...119,523,716
Ensembl chr 8:119,486,691...119,523,964
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases secretion ISO Arecoline results in decreased secretion of MMP2 protein CTD PMID:16311067 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Msh2 mutS homolog 2 decreases expression ISO Arecoline results in decreased expression of MSH2 mRNA CTD PMID:17682004 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932
JBrowse link
G Mt1 metallothionein 1 increases expression
multiple interactions
ISO Arecoline results in increased expression of MT1A mRNA
Benzo(a)pyrene promotes the reaction [Arecoline results in increased expression of MT1A mRNA]
CTD PMID:17418620 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO [arecoline hydrobromide results in increased abundance of Arecoline] which results in decreased phosphorylation of MTOR protein CTD PMID:30910432 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Myog myogenin decreases expression ISO Arecoline results in decreased expression of MYOG protein CTD PMID:23933062 NCBI chr13:51,126,459...51,129,048
Ensembl chr13:51,126,459...51,129,048
JBrowse link
G Nat8 N-acetyltransferase 8 decreases expression ISO Arecoline results in decreased expression of NAT8 mRNA CTD PMID:17682004 NCBI chr 4:117,525,963...117,527,443 JBrowse link
G Phlpp2 PH domain and leucine rich repeat protein phosphatase 2 multiple interactions ISO [arecoline hydrobromide results in increased abundance of Arecoline] which results in increased expression of PHLPP2 mRNA; PHLPP2 protein affects the reaction [[arecoline hydrobromide results in increased abundance of Arecoline] which results in decreased phosphorylation of AKT1 protein] CTD PMID:30910432 NCBI chr19:41,731,845...41,798,451
Ensembl chr19:41,731,646...41,798,383
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 increases expression EXP Arecoline results in increased expression of PIK3R1 mRNA CTD PMID:20724125 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit decreases expression ISO Arecoline results in decreased expression of PRKDC mRNA CTD PMID:17682004 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO Arecoline results in increased expression of PTGS2; Arecoline results in increased expression of PTGS2 mRNA
[Arecoline co-treated with 4-nitroquinolone-1-oxide] results in increased expression of PTGS2 protein; Dinoprostone inhibits the reaction [helioxanthin inhibits the reaction [[Arecoline co-treated with 4-nitroquinolone-1-oxide] results in increased expression of PTGS2 protein]]; helioxanthin inhibits the reaction [[Arecoline co-treated with 4-nitroquinolone-1-oxide] results in increased expression of PTGS2 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [helioxanthin inhibits the reaction [[Arecoline co-treated with 4-nitroquinolone-1-oxide] results in increased expression of PTGS2 protein]]
CTD PMID:16311067, PMID:17682004, PMID:26464283 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rad1 RAD1 checkpoint DNA exonuclease decreases expression ISO Arecoline results in decreased expression of RAD1 mRNA CTD PMID:17682004 NCBI chr 2:60,461,513...60,469,646
Ensembl chr 2:60,461,551...60,469,685
JBrowse link
G Rad50 RAD50 double strand break repair protein increases expression ISO Arecoline results in increased expression of RAD50 mRNA CTD PMID:17682004 NCBI chr10:39,002,130...39,054,042
Ensembl chr10:39,001,498...39,054,142
JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO Arecoline results in increased expression of SERPINE1 protein CTD PMID:26908192 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression EXP Arecoline results in increased expression of SLC2A4 mRNA CTD PMID:20724125 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Smc1a structural maintenance of chromosomes 1A decreases expression ISO Arecoline results in decreased expression of SMC1A mRNA CTD PMID:17682004 NCBI chr  X:21,710,976...21,755,708
Ensembl chr  X:21,711,019...21,755,525
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO Arecoline results in increased expression of TIMP1 mRNA; Arecoline results in increased expression of TIMP1 protein CTD PMID:16311067 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO [[Arecoline results in decreased expression of CDC25C] co-treated with [Arecoline results in increased expression of TP53]] results in decreased activity of CDK1 protein
Arecoline results in increased expression of TP53 protein
CTD PMID:22108589 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Uggt1 UDP-glucose glycoprotein glucosyltransferase 1 decreases expression ISO Arecoline results in decreased expression of UGGT1 mRNA CTD PMID:17682004 NCBI chr 9:42,692,156...42,805,680
Ensembl chr 9:42,692,105...42,805,673
JBrowse link
G Vim vimentin increases expression
multiple interactions
ISO Arecoline results in increased expression of VIM protein
U 0126 inhibits the reaction [Arecoline results in increased expression of VIM protein]
CTD PMID:32441858 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
azadirachtin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO azadirachtin results in increased expression of APAF1 protein CTD PMID:20429769 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO azadirachtin results in increased expression of BAD mRNA CTD PMID:20429769 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO azadirachtin results in increased expression of BAX mRNA CTD PMID:20429769 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO azadirachtin results in decreased expression of BCL2 mRNA; azadirachtin results in decreased expression of BCL2 protein CTD PMID:20429769 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO azadirachtin results in decreased expression of BCL2L1 mRNA CTD PMID:20429769 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO azadirachtin results in increased expression of BID mRNA CTD PMID:20429769 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO azadirachtin results in decreased expression of BIRC5 protein CTD PMID:20429769 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Casp3 caspase 3 increases expression ISO azadirachtin results in increased expression of CASP3 mRNA; azadirachtin results in increased expression of CASP3 protein CTD PMID:20429769 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp6 caspase 6 increases expression ISO azadirachtin results in increased expression of CASP6 protein CTD PMID:20429769 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casp8 caspase 8 increases expression ISO azadirachtin results in increased expression of CASP8 protein CTD PMID:20429769 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases expression ISO azadirachtin results in increased expression of CASP9 mRNA; azadirachtin results in increased expression of CASP9 protein CTD PMID:20429769 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO azadirachtin results in decreased expression of CCND1 mRNA CTD PMID:20429769 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO azadirachtin results in increased expression of CDKN1A mRNA; azadirachtin results in increased expression of CDKN1A protein CTD PMID:20429769 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cycs cytochrome c, somatic increases expression
affects localization
ISO azadirachtin results in increased expression of CYCS mRNA
azadirachtin affects the localization of CYCS protein
CTD PMID:20429769 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta decreases expression ISO azadirachtin results in decreased expression of IKBKB protein CTD PMID:20429769 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression ISO azadirachtin results in decreased expression of NFKB1 protein CTD PMID:20429769 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases expression ISO azadirachtin results in decreased expression of NFKBIA protein modified form CTD PMID:20429769 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO azadirachtin results in decreased expression of PCNA mRNA; azadirachtin results in decreased expression of PCNA protein CTD PMID:20429769 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO azadirachtin results in decreased expression of RELA protein CTD PMID:20429769 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tp53 tumor protein p53 increases expression ISO azadirachtin results in increased expression of TP53 mRNA; azadirachtin results in increased expression of TP53 protein CTD PMID:20429769 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
azoxystrobin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha increases phosphorylation
multiple interactions
ISO
EXP
azoxystrobin results in increased phosphorylation of ACACA protein
[azoxystrobin co-treated with Dietary Fats] affects the phosphorylation of ACACA protein
dorsomorphin inhibits the reaction [azoxystrobin results in increased phosphorylation of ACACA protein]
CTD PMID:24726979 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO azoxystrobin results in decreased phosphorylation of AKT1 protein CTD PMID:32339800 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Arg1 arginase 1 decreases expression ISO azoxystrobin results in decreased expression of ARG1 mRNA CTD PMID:32194361 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO azoxystrobin results in increased expression of CYP1A1 mRNA; azoxystrobin results in increased expression of CYP1A1 protein
[cyproconazole co-treated with azoxystrobin] results in increased expression of CYP1A1 mRNA
CTD PMID:21784029, PMID:29294346, PMID:32194361 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO azoxystrobin results in increased expression of CYP1A2 mRNA; azoxystrobin results in increased expression of CYP1A2 protein CTD PMID:21784029 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases expression
ISO [cyproconazole co-treated with azoxystrobin] results in increased expression of CYP2B6 protein
azoxystrobin results in increased expression of CYP2B6 protein
CTD PMID:29294346 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases expression ISO azoxystrobin results in decreased expression of CYP2C19 protein CTD PMID:32194361 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO azoxystrobin results in decreased expression of CYP7A1 mRNA; azoxystrobin results in decreased expression of CYP7A1 protein CTD PMID:32194361 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO [azoxystrobin co-treated with Dietary Fats] affects the expression of FASN mRNA CTD PMID:24726979 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO azoxystrobin results in decreased expression of G6PC mRNA CTD PMID:32194361 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Lep leptin multiple interactions ISO [azoxystrobin co-treated with Dietary Fats] affects the expression of LEP protein CTD PMID:24726979 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO azoxystrobin results in increased expression of MDM2 protein CTD PMID:32339800 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mt-atp6 mitochondrially encoded ATP synthase membrane subunit 6 decreases expression ISO azoxystrobin results in decreased expression of ATP6 protein CTD PMID:32339800 NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599
JBrowse link
G Mt-cyb mitochondrially encoded cytochrome b decreases expression ISO azoxystrobin results in decreased expression of CYTB protein CTD PMID:32339800 NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278
JBrowse link
G Rorc RAR-related orphan receptor C increases activity ISO azoxystrobin results in increased activity of RORC protein CTD PMID:20143881 NCBI chr 2:195,612,471...195,636,797
Ensembl chr 2:195,617,021...195,637,630
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO [azoxystrobin co-treated with Dietary Fats] affects the expression of SREBF1 mRNA CTD PMID:24726979 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Tbc1d4 TBC1 domain family, member 4 multiple interactions ISO [azoxystrobin co-treated with Dietary Fats] affects the phosphorylation of TBC1D4 protein CTD PMID:24726979 NCBI chr15:85,927,978...86,105,829
Ensembl chr15:85,930,044...86,105,273
JBrowse link
benzyl cinnamate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO benzyl cinnamate results in increased expression of AKR1C2 mRNA CTD PMID:20491607 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Cd86 CD86 molecule increases expression ISO benzyl cinnamate results in increased expression of CD86 protein CTD PMID:29540657 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO benzyl cinnamate results in increased expression of CYP1A1 mRNA CTD PMID:20491607 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO benzyl cinnamate results in increased expression of MAFF mRNA CTD PMID:20491607 NCBI chr 7:120,580,743...120,592,095
Ensembl chr 7:120,580,743...120,592,095
JBrowse link
G Maoa monoamine oxidase A decreases activity ISO benzyl cinnamate results in decreased activity of MAOA protein CTD PMID:27270453 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
G Maob monoamine oxidase B decreases activity ISO benzyl cinnamate results in decreased activity of MAOB protein CTD PMID:27270453 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Mt1 metallothionein 1 increases expression ISO benzyl cinnamate results in increased expression of MT1A mRNA CTD PMID:20491607 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt2A metallothionein 2A increases expression ISO benzyl cinnamate results in increased expression of MT2A mRNA CTD PMID:20491607 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO benzyl cinnamate results in increased expression of NQO1 mRNA CTD PMID:20491607 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Txn1 thioredoxin 1 increases expression ISO benzyl cinnamate results in increased expression of TXN mRNA CTD PMID:20491607 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
bisphenol A dimethacrylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO 2,2-di(4-methacryloxyphenyl)propane inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO [Bisphenol A-Glycidyl Methacrylate co-treated with 2,2-di(4-methacryloxyphenyl)propane co-treated with triethylene glycol dimethacrylate] results in increased activity of ESR1 protein CTD PMID:11145352 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO 2,2-di(4-methacryloxyphenyl)propane binds to and results in increased activity of NR1I2 protein CTD PMID:20869355 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO 2,2-di(4-methacryloxyphenyl)propane binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Pgr progesterone receptor increases expression ISO 2,2-di(4-methacryloxyphenyl)propane results in increased expression of PGR protein CTD PMID:8919768, PMID:9449681 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [2,2-di(4-methacryloxyphenyl)propane co-treated with triethylene glycol dimethacrylate co-treated with Bisphenol A-Glycidyl Methacrylate co-treated with Benzoyl Peroxide] results in increased expression of PTGS2 mRNA; [2,2-di(4-methacryloxyphenyl)propane co-treated with triethylene glycol dimethacrylate co-treated with Bisphenol A-Glycidyl Methacrylate co-treated with Benzoyl Peroxide] results in increased expression of PTGS2 protein CTD PMID:15264312 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
bryostatin 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc3 baculoviral IAP repeat-containing 3 increases expression ISO bryostatin 1 results in increased expression of BIRC3 mRNA CTD PMID:14527959 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Cd22 CD22 molecule increases expression ISO bryostatin 1 results in increased expression of CD22 protein CTD PMID:10741703 NCBI chr 1:89,313,475...89,329,902
Ensembl chr 1:89,314,558...89,329,418
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO bryostatin 1 inhibits the reaction [Paclitaxel results in increased activity of CDK1 protein] CTD PMID:10516758 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO bryostatin 1 results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Il10 interleukin 10 decreases expression ISO bryostatin 1 analog results in decreased expression of IL10 mRNA; bryostatin 1 results in decreased expression of IL10 mRNA CTD PMID:15614042 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12b interleukin 12B decreases expression
increases expression
ISO bryostatin 1 analog results in decreased expression of IL12B mRNA
bryostatin 1 results in increased expression of IL12B mRNA
CTD PMID:15614042 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Itgax integrin subunit alpha X increases expression ISO bryostatin 1 results in increased expression of ITGAX protein CTD PMID:10741703 NCBI chr 1:199,555,560...199,576,948
Ensembl chr 1:199,555,722...199,576,932
JBrowse link
G Prkca protein kinase C, alpha multiple interactions
decreases expression
ISO [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCA protein
bryostatin 1 results in decreased expression of PRKCA protein
CTD PMID:8892972 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Prkcb protein kinase C, beta multiple interactions
decreases expression
ISO [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCB protein; [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCB protein alternative form
bryostatin 1 results in decreased expression of PRKCB protein; bryostatin 1 results in decreased expression of PRKCB protein alternative form
CTD PMID:8892972 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Prkcg protein kinase C, gamma multiple interactions
decreases expression
ISO [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCG protein
bryostatin 1 results in decreased expression of PRKCG protein
CTD PMID:8892972 NCBI chr 1:64,407,098...64,433,698
Ensembl chr 1:64,407,114...64,433,636
JBrowse link
bryostatin 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F3 coagulation factor III, tissue factor increases expression ISO bryostatin 2 results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
chlorogenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of ABCC1 protein] CTD PMID:25043994 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of ABCC2 protein] CTD PMID:25043994 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Ache acetylcholinesterase decreases activity ISO Chlorogenic Acid results in decreased activity of ACHE protein CTD PMID:20854806 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Acly ATP citrate lyase increases expression ISO Chlorogenic Acid results in increased expression of ACLY mRNA CTD PMID:20706672 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:23146752 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Alb albumin multiple interactions EXP
ISO
Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of ALB protein]
Chlorogenic Acid affects the reaction [2,2'-azobis(2-amidinopropane) results in increased degradation of ALB protein]
CTD PMID:11322927, PMID:23146752 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aqp1 aquaporin 1 increases expression ISO Chlorogenic Acid results in increased expression of AQP1 mRNA CTD PMID:20706672 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) increases expression ISO Chlorogenic Acid results in increased expression of AQP3 mRNA CTD PMID:20706672 NCBI chr 5:57,423,735...57,429,252
Ensembl chr 5:57,423,734...57,429,245
JBrowse link
G Ar androgen receptor decreases expression ISO Chlorogenic Acid results in decreased expression of AR mRNA CTD PMID:20706672 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bambi BMP and activin membrane-bound inhibitor multiple interactions EXP Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of BAMBI mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of BAMBI protein] CTD PMID:23146752 NCBI chr17:56,905,419...56,909,675
Ensembl chr17:56,905,112...56,909,992
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP
Chlorogenic Acid inhibits the reaction [aluminum chloride results in increased expression of BAX protein]; Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of BAX protein]
Chlorogenic Acid inhibits the reaction [Methotrexate results in increased expression of BAX protein]
CTD PMID:25043994, PMID:28479099, PMID:28623112 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO
Chlorogenic Acid inhibits the reaction [Methotrexate results in decreased expression of BCL2 protein]
Chlorogenic Acid inhibits the reaction [aluminum chloride results in decreased expression of BCL2 protein]
CTD PMID:28479099, PMID:28623112 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
Chlorogenic Acid inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]
Chlorogenic Acid inhibits the reaction [Methotrexate results in increased activity of CASP3 protein]
CTD PMID:25043994, PMID:28479099 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Chlorogenic Acid inhibits the reaction [aluminum chloride results in increased expression of CASP8 protein] CTD PMID:28623112 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions EXP Chlorogenic Acid inhibits the reaction [Methotrexate results in increased activity of CASP9 protein] CTD PMID:28479099 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions EXP
ISO
Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of CAT protein]; Chlorogenic Acid inhibits the reaction [Methotrexate results in decreased activity of CAT protein]
Chlorogenic Acid inhibits the reaction [aluminum chloride results in decreased activity of CAT protein]
CTD PMID:28479099, PMID:28623112, PMID:31390532 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of CCL2 mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased secretion of CCL2 protein]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein] CTD PMID:26079055, PMID:31306686 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of CCND1 protein] CTD PMID:25043994 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression ISO Chlorogenic Acid results in increased expression of CD44 mRNA CTD PMID:20706672 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cdh1 cadherin 1 increases expression ISO Chlorogenic Acid results in increased expression of CDH1 mRNA CTD PMID:20706672 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression
multiple interactions
ISO
EXP
Chlorogenic Acid results in increased expression of COL1A1 mRNA
Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]
CTD PMID:20706672, PMID:23146752 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Amino Acids]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of phenylpyruvic acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Allantoin]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Amino Acids]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Carnitine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Citric Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatinine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of phenylacetylglycine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uric Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uridine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased secretion of IL1B protein] CTD PMID:24709313 NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997
JBrowse link
G Cs citrate synthase increases activity ISO Chlorogenic Acid results in increased activity of CS protein CTD PMID:31306686 NCBI chr 7:2,752,680...2,778,963
Ensembl chr 7:2,752,680...2,778,963
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of CXCL1 mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased secretion of CXCL1 protein] CTD PMID:26079055 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cygb cytoglobin decreases expression ISO Chlorogenic Acid results in decreased expression of CYGB mRNA CTD PMID:20706672 NCBI chr10:105,618,325...105,628,091
Ensembl chr10:105,618,326...105,628,091
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression EXP Chlorogenic Acid results in increased expression of CYP19A1 protein CTD PMID:29899696 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of CYP2E1 protein] CTD PMID:25043994 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Dsg3 desmoglein 3 decreases expression ISO Chlorogenic Acid results in decreased expression of DSG3 mRNA CTD PMID:20706672 NCBI chr18:15,652,948...15,688,605
Ensembl chr18:15,650,526...15,688,284
JBrowse link
G Egf epidermal growth factor decreases expression ISO Chlorogenic Acid results in decreased expression of EGF mRNA CTD PMID:20706672 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Esr1 estrogen receptor 1 decreases expression EXP Chlorogenic Acid results in decreased expression of ESR1 protein CTD PMID:29899696 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 increases expression EXP Chlorogenic Acid results in increased expression of ESR2 protein CTD PMID:29899696 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G F10 coagulation factor X decreases activity ISO Chlorogenic Acid results in decreased activity of F10 protein CTD PMID:27704645 NCBI chr16:81,803,169...81,822,476
Ensembl chr16:81,803,110...81,822,716
JBrowse link
G F2 coagulation factor II decreases activity ISO Chlorogenic Acid results in decreased activity of F2 protein CTD PMID:27704645 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G Fasn fatty acid synthase decreases expression ISO Chlorogenic Acid results in decreased expression of FASN mRNA CTD PMID:21870829 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fbn1 fibrillin 1 decreases expression ISO Chlorogenic Acid results in decreased expression of FBN1 mRNA CTD PMID:20706672 NCBI chr 3:117,569,708...117,766,160
Ensembl chr 3:117,569,697...117,766,120
JBrowse link
G Fbn2 fibrillin 2 decreases expression ISO Chlorogenic Acid results in decreased expression of FBN2 mRNA CTD PMID:20706672 NCBI chr18:53,068,495...53,272,254
Ensembl chr18:53,068,495...53,181,503
JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression ISO Chlorogenic Acid results in increased expression of FGF1 mRNA CTD PMID:20706672 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Fshr follicle stimulating hormone receptor increases expression EXP Chlorogenic Acid results in increased expression of FSHR protein CTD PMID:29899696 NCBI chr 6:12,796,383...12,997,817
Ensembl chr 6:12,796,383...12,997,817
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO Chlorogenic Acid results in increased expression of GCLC mRNA
Chlorogenic Acid promotes the reaction [Acetaminophen results in increased expression of GCLC mRNA]
CTD PMID:29136249 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Chlorogenic Acid results in increased expression of GCLM mRNA CTD PMID:29136249 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO
Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased activity of GPT protein]; Chlorogenic Acid inhibits the reaction [Methotrexate results in increased activity of GPT protein]
Chlorogenic Acid inhibits the reaction [aluminum chloride results in increased activity of GPT protein]
CTD PMID:28479099, PMID:28623112, PMID:31390532 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Grn granulin precursor increases expression ISO Chlorogenic Acid results in increased expression of GRN mRNA CTD PMID:20706672 NCBI chr10:90,377,103...90,383,207
Ensembl chr10:90,376,933...90,383,205
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Chlorogenic Acid inhibits the reaction [Methotrexate results in decreased activity of GSR protein] CTD PMID:28479099 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases activity ISO Chlorogenic Acid results in increased activity of GSTA1 protein CTD PMID:15944151 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
JBrowse link
G Has1 hyaluronan synthase 1 increases expression ISO Chlorogenic Acid results in increased expression of HAS1 mRNA CTD PMID:20706672 NCBI chr 1:59,720,612...59,732,409
Ensembl chr 1:59,720,612...59,732,409
JBrowse link
G Hlcs holocarboxylase synthetase decreases activity ISO Chlorogenic Acid results in decreased activity of HLCS protein CTD PMID:26303405 NCBI chr11:34,357,372...34,537,798
Ensembl chr11:34,352,287...34,526,931
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
decreases expression
EXP
ISO
[tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]; Chlorogenic Acid results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]
Chlorogenic Acid results in decreased expression of HMGCR mRNA
CTD PMID:20696151, PMID:21870829 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of HMOX1 protein]
Chlorogenic Acid results in increased expression of HMOX1 mRNA
Chlorogenic Acid inhibits the reaction [Acetaminophen results in decreased expression of HMOX1 mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in decreased expression of HMOX1 protein]
CTD PMID:25043994, PMID:29136249 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression ISO Chlorogenic Acid results in increased expression of HSPB1 mRNA CTD PMID:20706672 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO Chlorogenic Acid results in decreased expression of IL1A mRNA CTD PMID:20706672 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO
[geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased secretion of IL1B protein]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B mRNA]
Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of IL1B mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased secretion of IL1B protein]
CTD PMID:23146752, PMID:24709313, PMID:26079055 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO
EXP
Chlorogenic Acid results in increased expression of IL6 mRNA
Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of IL6 mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased secretion of IL6 protein]
Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL6 protein]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]
CTD PMID:21870829, PMID:23146752, PMID:26079055, PMID:31390532 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgb2 integrin subunit beta 2 decreases expression
multiple interactions
EXP Chlorogenic Acid results in decreased expression of ITGB2 protein
Chlorogenic Acid inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of ITGB2 protein]
CTD PMID:21414398 NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of JUN protein] CTD PMID:15944151 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Krt5 keratin 5 increases expression ISO Chlorogenic Acid results in increased expression of KRT5 mRNA CTD PMID:20706672 NCBI chr 7:143,320,142...143,324,536
Ensembl chr 7:143,316,920...143,453,546
JBrowse link
G Lcat lecithin cholesterol acyltransferase multiple interactions EXP [tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein]; Chlorogenic Acid results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein] CTD PMID:20696151 NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813
JBrowse link
G Lpl lipoprotein lipase multiple interactions EXP [tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LPL protein]; Chlorogenic Acid results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LPL protein] CTD PMID:20696151 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Maoa monoamine oxidase A decreases activity ISO Chlorogenic Acid results in decreased activity of MAOA protein CTD PMID:27270453 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
G Maob monoamine oxidase B decreases activity ISO Chlorogenic Acid results in decreased activity of MAOB protein CTD PMID:27270453 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAP2K4 protein] CTD PMID:15944151 NCBI chr10:52,196,121...52,301,887
Ensembl chr10:52,196,124...52,290,657
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
Chlorogenic Acid promotes the reaction [Acetaminophen results in increased phosphorylation of MAPK1 protein]
CTD PMID:15944151, PMID:29136249 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK14 protein] CTD PMID:15944151 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
Chlorogenic Acid promotes the reaction [Acetaminophen results in increased phosphorylation of MAPK3 protein]
CTD PMID:15944151, PMID:29136249 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mc1r melanocortin 1 receptor increases expression ISO Chlorogenic Acid results in increased expression of MC1R mRNA CTD PMID:20706672 NCBI chr19:56,215,420...56,219,987 JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 decreases activity EXP Chlorogenic Acid results in decreased activity of MGST1 protein CTD PMID:16125204 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of MPO protein] CTD PMID:26079055 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I increases expression ISO Chlorogenic Acid results in increased expression of COX1 mRNA CTD PMID:20706672 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II multiple interactions ISO [Chlorogenic Acid co-treated with Zymosan] results in decreased expression of COX2 protein; Chlorogenic Acid inhibits the reaction [Zymosan results in increased expression of COX2 protein] CTD PMID:30481570 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
JBrowse link
G Mt1 metallothionein 1 multiple interactions EXP Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MT1 mRNA]; Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MT1 protein] CTD PMID:31390532 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP
ISO
Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of MYD88 mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of MYD88 protein]
Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of MYD88 protein]
CTD PMID:23146752, PMID:26079055 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases localization
multiple interactions
increases response to substance
affects localization
decreases response to substance
ISO Chlorogenic Acid results in increased localization of NFE2L2 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Chlorogenic Acid co-treated with Acetaminophen] results in increased phosphorylation of and affects the localization of and results in increased activity of NFE2L2 protein]; [Chlorogenic Acid co-treated with Acetaminophen] results in increased activity of and affects the localization of NFE2L2 protein; [Chlorogenic Acid co-treated with Acetaminophen] results in increased phosphorylation of and affects the localization of and results in increased activity of NFE2L2 protein; U 0126 inhibits the reaction [[Chlorogenic Acid co-treated with Acetaminophen] results in increased phosphorylation of and affects the localization of and results in increased activity of NFE2L2 protein]
[Chlorogenic Acid co-treated with Acetaminophen] affects the localization of and results in increased activity of NFE2L2 protein
NFE2L2 results in increased susceptibility to Chlorogenic Acid
Chlorogenic Acid affects the localization of NFE2L2 protein
NFE2L2 gene mutant form results in decreased susceptibility to Chlorogenic Acid
CTD PMID:15944151, PMID:29136249 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO
EXP
Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]
Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of and results in increased phosphorylation of NFKBIA protein]
CTD PMID:20026373, PMID:23146752 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nfkbib NFKB inhibitor beta multiple interactions ISO Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of NFKBIB protein] CTD PMID:20026373 NCBI chr 1:86,941,073...86,948,845
Ensembl chr 1:86,941,074...86,948,845
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
Chlorogenic Acid inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein]
Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; Chlorogenic Acid inhibits the reaction [Methotrexate results in increased expression of NOS2 protein]
CTD PMID:20026373, PMID:23146752, PMID:28479099, PMID:31306686 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression ISO Chlorogenic Acid results in increased expression of NOS3 mRNA CTD PMID:20706672 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression
multiple interactions
ISO Chlorogenic Acid results in increased activity of NQO1 protein
Chlorogenic Acid results in increased expression of NQO1 mRNA
Chlorogenic Acid inhibits the reaction [Acetaminophen results in decreased expression of NQO1 mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in decreased expression of NQO1 protein]
CTD PMID:15944151, PMID:29136249 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Ocln occludin multiple interactions EXP Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of OCLN mRNA]; Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of OCLN protein] CTD PMID:31390532 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Chlorogenic Acid promotes the reaction [Cisplatin results in increased expression of PCNA protein] CTD PMID:25043994 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions EXP Chlorogenic Acid inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of PECAM1 protein] CTD PMID:21414398 NCBI chr10:94,850,971...94,913,202 JBrowse link
G Pgr progesterone receptor increases expression
decreases expression
ISO Chlorogenic Acid results in increased expression of PGR mRNA
Chlorogenic Acid results in decreased expression of PGR mRNA
CTD PMID:20706672 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 increases expression ISO Chlorogenic Acid results in increased expression of PIK3R1 mRNA CTD PMID:21870829 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 increases expression ISO Chlorogenic Acid results in increased expression of PLOD3 mRNA CTD PMID:20706672 NCBI chr12:22,716,421...22,726,982
Ensembl chr12:22,716,423...22,726,982
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
decreases expression
ISO Chlorogenic Acid results in increased expression of PPARG mRNA
Chlorogenic Acid results in decreased expression of PPARG mRNA
CTD PMID:20706672, PMID:21870829 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha multiple interactions ISO [Chlorogenic Acid co-treated with Acetaminophen] results in decreased expression of PPP2R1A protein CTD PMID:29136249 NCBI chr 1:60,717,386...60,736,629
Ensembl chr 1:60,717,386...60,736,609
JBrowse link
G Ppp5c protein phosphatase 5, catalytic subunit multiple interactions ISO [Chlorogenic Acid co-treated with Acetaminophen] results in decreased expression of PPP5C protein CTD PMID:29136249 NCBI chr 1:78,944,054...78,968,361
Ensembl chr 1:78,944,040...78,968,329
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO
Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]; Chlorogenic Acid inhibits the reaction [Methotrexate results in increased expression of PTGS2 protein]
Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of and results in increased expression of PTGS2 protein]
CTD PMID:20026373, PMID:23146752, PMID:25043994, PMID:28479099, PMID:31306686 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rad23a RAD23 homolog A, nucleotide excision repair protein decreases expression ISO Chlorogenic Acid results in decreased expression of RAD23A mRNA CTD PMID:20706672 NCBI chr19:25,949,488...25,956,677
Ensembl chr19:25,949,490...25,955,391
JBrowse link
G Rara retinoic acid receptor, alpha increases expression ISO Chlorogenic Acid results in increased expression of RARA mRNA CTD PMID:20706672 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of and results in increased phosphorylation of and affects the localization of RELA protein]; Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of RELA protein] CTD PMID:20026373, PMID:26079055 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rxra retinoid X receptor alpha decreases expression ISO Chlorogenic Acid results in decreased expression of RXRA mRNA CTD PMID:20706672 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Sell selectin L multiple interactions EXP [Chlorogenic Acid co-treated with lipopolysaccharide, E. coli O26-B6] results in increased expression of SELL protein; Chlorogenic Acid inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in decreased expression of SELL protein] CTD PMID:21414398 NCBI chr13:82,369,820...82,387,774
Ensembl chr13:82,369,493...82,387,631
JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions EXP Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SLC11A2 mRNA]; Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SLC11A2 protein] CTD PMID:31390532 NCBI chr 7:142,025,812...142,062,892
Ensembl chr 7:142,025,815...142,063,212
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Cisplatin results in decreased expression of SLC22A2 protein] CTD PMID:25043994 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression ISO Chlorogenic Acid results in increased expression of SLC2A4 mRNA CTD PMID:21870829 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Sod3 superoxide dismutase 3 decreases expression ISO Chlorogenic Acid results in decreased expression of SOD3 mRNA CTD PMID:20706672 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Acetaminophen results in decreased expression of SQSTM1 protein] CTD PMID:29136249 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 decreases expression ISO Chlorogenic Acid results in decreased expression of SRD5A2 mRNA CTD PMID:20706672 NCBI chr 6:25,279,635...25,315,501
Ensembl chr 6:25,279,626...25,315,511
JBrowse link
G Star steroidogenic acute regulatory protein increases expression EXP Chlorogenic Acid results in increased expression of STAR protein CTD PMID:29899696 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions EXP Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of TJP1 mRNA]; Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of TJP1 protein] CTD PMID:31390532 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link
G Tlr3 toll-like receptor 3 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of TLR3 protein] CTD PMID:26079055 NCBI chr16:50,016,466...50,031,011
Ensembl chr16:50,016,857...50,031,214
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP
ISO
Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 protein]
Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of TLR4 protein]
CTD PMID:23146752, PMID:26079055 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO
EXP
Chlorogenic Acid results in increased expression of TNF mRNA
Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased secretion of TNF protein]; Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNF protein]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]
CTD PMID:21870829, PMID:23146752, PMID:25043994, PMID:26079055, PMID:31306686, PMID:31390532 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of TRP53 protein] CTD PMID:25043994 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 increases expression ISO Chlorogenic Acid results in increased expression of TPT1 mRNA CTD PMID:20706672 NCBI chr15:57,891,680...57,894,504
Ensembl chr15:57,891,680...57,894,504
JBrowse link
G Txn1 thioredoxin 1 increases expression ISO Chlorogenic Acid results in increased expression of TXN mRNA CTD PMID:20706672 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Tyr tyrosinase increases oxidation
multiple interactions
ISO TYR protein results in increased oxidation of Chlorogenic Acid
[TYR protein results in increased oxidation of Chlorogenic Acid] which results in decreased abundance of Glutathione
CTD PMID:20685355 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link
G Tyrp1 tyrosinase-related protein 1 decreases expression ISO Chlorogenic Acid results in decreased expression of TYRP1 mRNA CTD PMID:20706672 NCBI chr 5:98,387,291...98,406,083
Ensembl chr 5:98,387,291...98,406,083
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Chlorogenic Acid CTD PMID:15117964 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of Chlorogenic Acid CTD PMID:15117964 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
diethyl maleate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO diethyl maleate results in increased expression of ABCC2 mRNA CTD PMID:25270620 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abhd4 abhydrolase domain containing 4, N-acyl phospholipase B increases expression ISO diethyl maleate results in increased expression of ABHD4 mRNA CTD PMID:25270620 NCBI chr15:32,888,233...32,906,861
Ensembl chr15:32,894,938...32,906,850
JBrowse link
G Acaca acetyl-CoA carboxylase alpha decreases expression ISO diethyl maleate results in decreased expression of ACACA mRNA CTD PMID:25270620 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions EXP diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]; resveratrol inhibits the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]; resveratrol promotes the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]] CTD PMID:17134953 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Acy3 aminoacylase 3 decreases expression EXP diethyl maleate results in decreased expression of ACY3 mRNA CTD PMID:21161181 NCBI chr 1:219,233,712...219,237,103
Ensembl chr 1:219,233,750...219,237,098
JBrowse link
G Adora3 adenosine A3 receptor decreases expression EXP diethyl maleate results in decreased expression of ADORA3 mRNA CTD PMID:21161181 NCBI chr 2:208,336,909...208,379,217
Ensembl chr 2:208,373,154...208,376,803
JBrowse link
G Afp alpha-fetoprotein increases expression ISO diethyl maleate results in increased expression of AFP mRNA CTD PMID:25270620 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Ahcyl1 adenosylhomocysteinase-like 1 increases expression ISO diethyl maleate results in increased expression of AHCYL1 mRNA CTD PMID:25270620 NCBI chr 2:210,438,884...210,474,350
Ensembl chr 2:210,438,893...210,473,761
JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 increases expression EXP diethyl maleate results in increased expression of AKR1A1 protein CTD PMID:21161181 NCBI chr 5:135,482,068...135,498,693
Ensembl chr 5:135,482,068...135,498,822
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO diethyl maleate results in increased expression of AKR1C2 mRNA CTD PMID:20491607 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 affects reduction ISO diethyl maleate affects the reduction of ALDH1A1 protein CTD PMID:19843705 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 decreases expression EXP diethyl maleate results in decreased expression of ALDH1B1 mRNA CTD PMID:21161181 NCBI chr 5:61,382,351...61,387,359
Ensembl chr 5:61,382,351...61,387,358
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member decreases reduction
increases expression
decreases expression
ISO
EXP
diethyl maleate results in decreased reduction of ALDH2 protein
diethyl maleate results in increased expression of ALDH2 protein
diethyl maleate results in decreased expression of ALDH2 protein
CTD PMID:19843705, PMID:21161181 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
G Aldob aldolase, fructose-bisphosphate B decreases expression EXP diethyl maleate results in decreased expression of ALDOB protein CTD PMID:21161181 NCBI chr 5:64,805,772...64,818,813
Ensembl chr 5:64,805,773...64,818,824
JBrowse link
G Amigo2 adhesion molecule with Ig like domain 2 decreases expression EXP diethyl maleate results in decreased expression of AMIGO2 mRNA CTD PMID:21161181 NCBI chr 7:138,704,124...138,707,221
Ensembl chr 7:138,704,126...138,707,221
JBrowse link
G Angptl2 angiopoietin-like 2 decreases expression EXP diethyl maleate results in decreased expression of ANGPTL2 mRNA CTD PMID:21161181 NCBI chr 3:12,262,822...12,292,665
Ensembl chr 3:12,262,822...12,292,663
JBrowse link
G Ankrd46 ankyrin repeat domain 46 decreases expression EXP diethyl maleate results in decreased expression of ANKRD46 mRNA CTD PMID:21161181 NCBI chr 7:75,279,443...75,300,442
Ensembl chr 7:75,279,446...75,288,365
JBrowse link
G Anln anillin, actin binding protein increases expression EXP diethyl maleate results in increased expression of ANLN mRNA CTD PMID:21161181 NCBI chr 8:23,336,455...23,397,122
Ensembl chr 8:23,337,621...23,390,773
JBrowse link
G Anxa3 annexin A3 decreases expression EXP diethyl maleate results in decreased expression of ANXA3 mRNA CTD PMID:21161181 NCBI chr14:14,371,921...14,426,503
Ensembl chr14:14,364,008...14,426,437
JBrowse link
G Ap3m2 adaptor related protein complex 3 subunit mu 2 decreases expression EXP diethyl maleate results in decreased expression of AP3M2 mRNA CTD PMID:21161181 NCBI chr16:74,075,842...74,091,230
Ensembl chr16:74,076,812...74,091,139
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO diethyl maleate results in increased expression of APAF1 mRNA CTD PMID:11875189 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Aplp1 amyloid beta precursor like protein 1 decreases expression ISO diethyl maleate results in decreased expression of APLP1 mRNA CTD PMID:25270620 NCBI chr 1:88,897,525...88,908,750
Ensembl chr 1:88,897,532...88,908,750
JBrowse link
G Apol9a apolipoprotein L 9a decreases expression EXP diethyl maleate results in decreased expression of APOL9A mRNA CTD PMID:21161181 NCBI chr 7:118,927,013...118,933,778
Ensembl chr 7:118,927,008...118,933,812
JBrowse link
G Arrdc2 arrestin domain containing 2 decreases expression EXP diethyl maleate results in decreased expression of ARRDC2 mRNA CTD PMID:21161181 NCBI chr16:20,352,480...20,356,612
Ensembl chr16:20,352,480...20,356,612
JBrowse link
G Arrdc4 arrestin domain containing 4 decreases expression ISO diethyl maleate results in decreased expression of ARRDC4 mRNA CTD PMID:25270620 NCBI chr 1:129,766,097...129,780,076
Ensembl chr 1:129,766,100...129,780,356
JBrowse link
G Asf1b anti-silencing function 1B histone chaperone increases expression EXP diethyl maleate results in increased expression of ASF1B mRNA CTD PMID:21161181 NCBI chr19:25,077,918...25,092,491
Ensembl chr19:25,077,918...25,092,491
JBrowse link
G Asxl1 ASXL transcriptional regulator 1 decreases expression ISO diethyl maleate results in decreased expression of ASXL1 mRNA CTD PMID:25270620 NCBI chr 3:148,832,231...148,902,356
Ensembl chr 3:148,837,814...148,900,452
JBrowse link
G Atm ATM serine/threonine kinase increases expression ISO diethyl maleate results in increased expression of ATM mRNA CTD PMID:11875189 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta increases expression EXP diethyl maleate results in increased expression of ATP5F1B protein CTD PMID:21161181 NCBI chr 7:2,504,708...2,511,748
Ensembl chr 7:2,504,695...2,511,749
JBrowse link
G Aurka aurora kinase A increases expression
decreases expression
EXP
ISO
diethyl maleate results in increased expression of AURKA mRNA
diethyl maleate results in decreased expression of AURKA mRNA
CTD PMID:21161181, PMID:25270620 NCBI chr 3:170,364,177...170,380,278
Ensembl chr 3:170,364,181...170,378,210
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [diethyl maleate results in decreased abundance of Glutathione] which results in increased expression of BCL2 mRNA CTD PMID:22564015 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression EXP diethyl maleate results in decreased expression of BCL2A1 mRNA CTD PMID:21161181 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
JBrowse link
G Bcl3 BCL3, transcription coactivator decreases expression ISO diethyl maleate results in decreased expression of BCL3 mRNA CTD PMID:25270620 NCBI chr 1:80,730,758...80,745,273
Ensembl chr 1:80,730,499...80,744,831
JBrowse link
G Bcl6b BCL6B, transcription repressor decreases expression EXP diethyl maleate results in decreased expression of BCL6B mRNA CTD PMID:21161181 NCBI chr10:56,834,363...56,840,058
Ensembl chr10:56,834,364...56,839,437
JBrowse link
G Bhlhe41 basic helix-loop-helix family, member e41 decreases expression EXP diethyl maleate results in decreased expression of BHLHE41 mRNA CTD PMID:21161181 NCBI chr 4:180,230,742...180,235,138
Ensembl chr 4:180,232,382...180,234,804
JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase decreases expression EXP diethyl maleate results in decreased expression of BHMT mRNA CTD PMID:21161181 NCBI chr 2:23,236,573...23,256,158
Ensembl chr 2:23,236,575...23,256,158
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO diethyl maleate inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA] CTD PMID:12774022 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Blvrb biliverdin reductase B increases expression ISO diethyl maleate results in increased expression of BLVRB mRNA CTD PMID:25270620 NCBI chr 1:84,256,063...84,273,726
Ensembl chr 1:84,256,159...84,274,075
JBrowse link
G Bmf Bcl2 modifying factor decreases expression EXP diethyl maleate results in decreased expression of BMF mRNA CTD PMID:21161181 NCBI chr 3:110,303,515...110,324,125
Ensembl chr 3:110,306,067...110,324,084
JBrowse link
G Brip1 BRCA1 interacting protein C-terminal helicase 1 increases expression EXP diethyl maleate results in increased expression of BRIP1 mRNA CTD PMID:21161181 NCBI chr10:73,507,009...73,632,742
Ensembl chr10:73,507,100...73,629,581
JBrowse link
G Btbd2 BTB domain containing 2 decreases expression EXP diethyl maleate results in decreased expression of BTBD2 mRNA CTD PMID:21161181 NCBI chr 7:11,929,859...11,943,559
Ensembl chr 7:11,930,135...11,942,799
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression
decreases expression
multiple interactions
ISO diethyl maleate results in increased expression of BTG2 mRNA
diethyl maleate results in decreased expression of BTG2 mRNA
NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]; TRP53 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]
CTD PMID:22003191, PMID:25270620 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
JBrowse link
G C6 complement C6 decreases expression EXP diethyl maleate results in decreased expression of C6 mRNA CTD PMID:21161181 NCBI chr 2:54,460,333...54,533,801
Ensembl chr 2:54,466,280...54,533,797
JBrowse link
G Casp2 caspase 2 increases expression ISO diethyl maleate results in increased expression of CASP2 mRNA CTD PMID:11875189 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Casp3 caspase 3 increases expression
increases cleavage
ISO diethyl maleate results in increased expression of CASP3 mRNA
diethyl maleate results in increased cleavage of CASP3 protein
CTD PMID:11875189, PMID:21105742 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases expression ISO diethyl maleate results in increased expression of CASP9 mRNA CTD PMID:11875189 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase decreases expression EXP diethyl maleate results in decreased expression of CAT protein CTD PMID:21161181 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cbr1 carbonyl reductase 1 increases expression ISO diethyl maleate results in increased expression of CBR1 mRNA CTD PMID:25270620 NCBI chr11:33,813,041...33,815,418
Ensembl chr11:33,845,463...33,847,793
JBrowse link
G Cbr3 carbonyl reductase 3 increases expression
multiple interactions
ISO diethyl maleate results in increased expression of CBR3 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [diethyl maleate results in increased expression of CBR3 mRNA]
CTD PMID:20806931, PMID:25270620 NCBI chr11:33,909,417...33,917,674
Ensembl chr11:33,909,439...33,917,674
JBrowse link
G Ccdc50 coiled-coil domain containing 50 decreases expression ISO diethyl maleate results in decreased expression of CCDC50 mRNA CTD PMID:25270620 NCBI chr11:76,742,179...76,804,695
Ensembl chr11:76,747,865...76,804,510
JBrowse link
G Ccna1 cyclin A1 decreases expression ISO diethyl maleate results in decreased expression of CCNA1 mRNA CTD PMID:11875189 NCBI chr 2:144,456,689...144,503,570
Ensembl chr 2:144,458,153...144,467,912
JBrowse link
G Ccna2 cyclin A2 increases expression EXP diethyl maleate results in increased expression of CCNA2 mRNA CTD PMID:21161181 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnd1 cyclin D1 decreases expression
increases expression
ISO
EXP
diethyl maleate results in decreased expression of CCND1 mRNA
diethyl maleate results in increased expression of CCND1 mRNA
CTD PMID:11875189, PMID:21161181, PMID:25270620 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne2 cyclin E2 increases expression EXP diethyl maleate results in increased expression of CCNE2 mRNA CTD PMID:21161181 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Ccnk cyclin K decreases expression ISO diethyl maleate results in decreased expression of CCNK mRNA CTD PMID:11875189 NCBI chr 6:132,090,235...132,113,560
Ensembl chr 6:132,090,218...132,113,557
JBrowse link
G Cd80 Cd80 molecule multiple interactions
increases expression
ISO [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein
diethyl maleate results in increased expression of CD80 protein
CTD PMID:31958493 NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353
JBrowse link
G Cd86 CD86 molecule multiple interactions
increases expression
ISO [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein; bisindolylmaleimide I inhibits the reaction [diethyl maleate results in increased expression of CD86 protein] CTD PMID:24136171, PMID:31958493 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cdc25a cell division cycle 25A increases expression EXP diethyl maleate results in increased expression of CDC25A mRNA CTD PMID:21161181 NCBI chr 8:117,953,223...117,971,552
Ensembl chr 8:117,953,444...117,971,519
JBrowse link
G Cdca2 cell division cycle associated 2 increases expression EXP diethyl maleate results in increased expression of CDCA2 mRNA CTD PMID:21161181 NCBI chr15:44,365,396...44,411,601
Ensembl chr15:44,365,405...44,411,004
JBrowse link
G Cdca3 cell division cycle associated 3 increases expression EXP diethyl maleate results in increased expression of CDCA3 mRNA CTD PMID:21161181 NCBI chr 4:157,347,876...157,351,889
Ensembl chr 4:157,348,020...157,351,604
JBrowse link
G Cdca8 cell division cycle associated 8 increases expression EXP diethyl maleate results in increased expression of CDCA8 mRNA CTD PMID:21161181 NCBI chr 5:142,911,310...142,933,536
Ensembl chr 5:142,911,305...142,933,526
JBrowse link
G Cdh11 cadherin 11 decreases expression EXP diethyl maleate results in decreased expression of CDH11 mRNA CTD PMID:21161181 NCBI chr19:2,391,181...2,551,245
Ensembl chr19:2,393,059...2,551,245
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO diethyl maleate results in increased expression of CDKN1A mRNA; diethyl maleate results in increased expression of CDKN1A protein
TP53 protein affects the reaction [diethyl maleate results in increased expression of CDKN1A protein]
CTD PMID:11875189, PMID:27982581 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cds2 CDP-diacylglycerol synthase 2 increases expression ISO diethyl maleate results in increased expression of CDS2 mRNA CTD PMID:25270620 NCBI chr 3:124,896,657...124,935,221
Ensembl chr 3:124,896,618...124,935,226
JBrowse link
G Ces1d carboxylesterase 1D decreases expression
increases reduction
EXP
ISO
diethyl maleate results in decreased expression of CES1D protein
diethyl maleate results in increased reduction of CES1D protein
CTD PMID:19843705, PMID:21161181 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression EXP diethyl maleate results in decreased expression of CFLAR mRNA CTD PMID:21161181 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Cidec cell death-inducing DFFA-like effector c decreases expression EXP diethyl maleate results in decreased expression of CIDEC mRNA CTD PMID:21161181 NCBI chr 4:145,377,482...145,390,497
Ensembl chr 4:145,377,431...145,390,497
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 decreases expression EXP diethyl maleate results in decreased expression of CITED2 mRNA CTD PMID:21161181 NCBI chr 1:12,823,363...12,825,806
Ensembl chr 1:12,823,363...12,825,786
JBrowse link
G Cited4 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 decreases expression EXP diethyl maleate results in decreased expression of CITED4 mRNA CTD PMID:21161181 NCBI chr 5:139,597,731...139,598,622
Ensembl chr 5:139,597,731...139,598,622
JBrowse link
G Ckb creatine kinase B decreases reduction ISO diethyl maleate results in decreased reduction of CKB protein CTD PMID:19843705 NCBI chr 6:136,142,956...136,145,838
Ensembl chr 6:136,142,956...136,145,837
JBrowse link
G Cmpk2 cytidine/uridine monophosphate kinase 2 decreases expression EXP diethyl maleate results in decreased expression of CMPK2 mRNA CTD PMID:21161181 NCBI chr 6:45,683,242...45,694,824
Ensembl chr 6:45,683,234...45,694,822
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression EXP diethyl maleate results in decreased expression of COL1A1 mRNA CTD PMID:21161181 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression ISO diethyl maleate results in decreased expression of COL3A1 mRNA CTD PMID:25270620 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Commd3 COMM domain containing 3 increases expression ISO diethyl maleate results in increased expression of COMMD3 mRNA CTD PMID:25270620 NCBI chr17:85,356,042...85,359,835
Ensembl chr17:85,356,042...85,359,833
JBrowse link
G Comt catechol-O-methyltransferase decreases expression EXP diethyl maleate results in decreased expression of COMT mRNA CTD PMID:21161181 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Cp ceruloplasmin decreases expression ISO diethyl maleate results in decreased expression of CP mRNA CTD PMID:25270620 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Crym crystallin, mu decreases expression EXP diethyl maleate results in decreased expression of CRYM mRNA CTD PMID:21161181 NCBI chr 1:189,944,895...189,960,069
Ensembl chr 1:189,944,895...189,960,073
JBrowse link
G Csrp1 cysteine and glycine-rich protein 1 decreases expression EXP diethyl maleate results in decreased expression of CSRP1 mRNA CTD PMID:21161181 NCBI chr13:52,553,843...52,575,054
Ensembl chr13:52,553,775...52,575,051
JBrowse link
G Csrp3 cysteine and glycine rich protein 3 decreases reduction ISO diethyl maleate results in decreased reduction of CSRP3 protein CTD PMID:19843705 NCBI chr 1:104,147,205...104,166,389
Ensembl chr 1:104,147,206...104,166,367
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression EXP diethyl maleate results in decreased expression of CXCL10 mRNA CTD PMID:21161181 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression EXP diethyl maleate results in decreased expression of CXCL12 mRNA CTD PMID:21161181 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 decreases expression EXP diethyl maleate results in decreased expression of CXCL9 mRNA CTD PMID:21161181 NCBI chr14:17,228,832...17,233,743
Ensembl chr14:17,228,856...17,234,712
JBrowse link
G Cyb5a cytochrome b5 type A increases expression ISO diethyl maleate results in increased expression of CYB5A mRNA CTD PMID:25270620 NCBI chr18:81,694,818...81,726,821
Ensembl chr18:81,694,808...81,726,821
JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 decreases expression EXP diethyl maleate results in decreased expression of CYP26B1 mRNA CTD PMID:21161181 NCBI chr 4:116,261,796...116,278,615
Ensembl chr 4:116,261,796...116,278,615
JBrowse link
G Dbp D-box binding PAR bZIP transcription factor decreases expression EXP diethyl maleate results in decreased expression of DBP mRNA CTD PMID:21161181 NCBI chr 1:101,687,896...101,692,845
Ensembl chr 1:101,687,855...101,692,846
JBrowse link
G Ddit4l DNA-damage-inducible transcript 4-like increases expression ISO diethyl maleate results in increased expression of DDIT4L mRNA CTD PMID:25270620 NCBI chr 2:242,882,219...242,885,088
Ensembl chr 2:242,882,306...242,885,131
JBrowse link
G Dhx58 DEXH-box helicase 58 decreases expression EXP diethyl maleate results in decreased expression of DHX58 mRNA CTD PMID:21161181 NCBI chr10:88,599,722...88,611,562
Ensembl chr10:88,599,680...88,611,105
JBrowse link
G Dnmbp dynamin binding protein decreases expression EXP diethyl maleate results in decreased expression of DNMBP mRNA CTD PMID:21161181 NCBI chr 1:263,625,503...263,718,784
Ensembl chr 1:263,625,501...263,718,745
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 decreases reduction ISO diethyl maleate results in decreased reduction of DPYSL2 protein CTD PMID:19843705 NCBI chr15:43,475,640...43,581,725
Ensembl chr15:43,477,629...43,542,939
JBrowse link
G Dtx3l deltex E3 ubiquitin ligase 3L decreases expression EXP diethyl maleate results in decreased expression of DTX3L mRNA CTD PMID:21161181 NCBI chr11:67,758,093...67,767,623
NCBI chr11:67,768,542...67,772,428
Ensembl chr11:67,757,928...67,767,622
JBrowse link
G Dus3l dihydrouridine synthase 3-like decreases expression ISO diethyl maleate results in decreased expression of DUS3L mRNA CTD PMID:25270620 NCBI chr 9:10,289,440...10,294,213
Ensembl chr 9:10,289,446...10,293,980
JBrowse link
G Eef2k eukaryotic elongation factor-2 kinase decreases expression EXP diethyl maleate results in decreased expression of EEF2K mRNA CTD PMID:21161181 NCBI chr 1:190,780,211...190,839,926
Ensembl chr 1:190,780,236...190,842,324
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 decreases expression EXP diethyl maleate results in decreased expression of EIF2AK2 mRNA CTD PMID:21161181 NCBI chr 6:1,428,845...1,466,193
Ensembl chr 6:1,428,834...1,466,201
JBrowse link
G Entpd5 ectonucleoside triphosphate diphosphohydrolase 5 increases expression ISO diethyl maleate results in increased expression of ENTPD5 mRNA CTD PMID:25270620 NCBI chr 6:108,087,677...108,123,811
Ensembl chr 6:108,087,418...108,120,579
JBrowse link
G Eras ES cell expressed Ras decreases expression ISO diethyl maleate results in decreased expression of ERAS mRNA CTD PMID:25270620 NCBI chr  X:15,318,215...15,322,601
Ensembl chr  X:15,419,028...15,423,414
Ensembl chr  X:15,419,028...15,423,414
JBrowse link
G Ercc6l ERCC excision repair 6 like, spindle assembly checkpoint helicase increases expression EXP diethyl maleate results in increased expression of ERCC6L mRNA CTD PMID:21161181 NCBI chr  X:72,018,373...72,034,140
Ensembl chr  X:72,018,373...72,034,099
JBrowse link
G Exo1 exonuclease 1 increases expression EXP diethyl maleate results in increased expression of EXO1 mRNA CTD PMID:21161181 NCBI chr13:93,936,989...93,962,749
Ensembl chr13:93,939,022...93,960,342
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression EXP diethyl maleate results in increased expression of FABP1 protein CTD PMID:21161181 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Fabp7 fatty acid binding protein 7 decreases expression EXP diethyl maleate results in decreased expression of FABP7 mRNA CTD PMID:21161181 NCBI chr20:40,769,624...40,773,156
Ensembl chr20:40,769,586...40,773,349
JBrowse link
G Fam126b family with sequence similarity 126, member B decreases expression EXP diethyl maleate results in decreased expression of FAM126B mRNA CTD PMID:21161181 NCBI chr 9:65,406,136...65,478,399
Ensembl chr 9:65,406,138...65,442,257
JBrowse link
G Fasn fatty acid synthase decreases expression EXP diethyl maleate results in decreased expression of FASN mRNA CTD PMID:21161181 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fbn1 fibrillin 1 decreases expression EXP diethyl maleate results in decreased expression of FBN1 mRNA CTD PMID:21161181 NCBI chr 3:117,569,708...117,766,160
Ensembl chr 3:117,569,697...117,766,120
JBrowse link
G Fbp1 fructose-bisphosphatase 1 decreases expression EXP diethyl maleate results in decreased expression of FBP1 protein CTD PMID:21161181 NCBI chr17:396,175...417,480
Ensembl chr17:396,180...417,480
JBrowse link
G Fgf17 fibroblast growth factor 17 decreases expression ISO diethyl maleate results in decreased expression of FGF17 mRNA CTD PMID:25270620 NCBI chr15:52,326,758...52,337,360
Ensembl chr15:52,326,778...52,332,097
JBrowse link
G Fgg fibrinogen gamma chain decreases expression ISO diethyl maleate results in decreased expression of FGG mRNA CTD PMID:25270620 NCBI chr 2:181,987,080...181,994,523
Ensembl chr 2:181,987,217...181,994,514
JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase decreases expression EXP diethyl maleate results in decreased expression of FGR mRNA CTD PMID:21161181 NCBI chr 5:151,172,189...151,199,746
Ensembl chr 5:151,172,206...151,199,745
JBrowse link
G Fndc3b fibronectin type III domain containing 3B decreases expression ISO diethyl maleate results in decreased expression of FNDC3B mRNA CTD PMID:25270620 NCBI chr 2:113,109,949...113,415,171
Ensembl chr 2:113,112,902...113,345,577
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO diethyl maleate results in increased expression of FOS mRNA CTD PMID:10915739 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO diethyl maleate results in decreased expression of G6PC mRNA CTD PMID:25270620 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity EXP diethyl maleate results in increased activity of G6PD protein CTD PMID:3099627 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gab1 GRB2-associated binding protein 1 decreases expression ISO diethyl maleate results in decreased expression of GAB1 mRNA CTD PMID:25270620 NCBI chr19:30,794,290...30,903,819
Ensembl chr19:30,794,571...30,902,008
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase increases reduction ISO diethyl maleate results in increased reduction of GAPDH protein CTD PMID:19843705 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Gba2 glucosylceramidase beta 2 decreases expression ISO diethyl maleate results in decreased expression of GBA2 mRNA CTD PMID:25270620 NCBI chr 5:59,068,081...59,079,719
Ensembl chr 5:59,068,081...59,079,719
JBrowse link
G Gbp2 guanylate binding protein 2 decreases expression EXP diethyl maleate results in decreased expression of GBP2 mRNA CTD PMID:21161181 NCBI chr 2:248,276,795...248,293,784
Ensembl chr 2:248,276,709...248,293,784
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases activity
increases expression
ISO
EXP
diethyl maleate results in increased activity of GCLC protein
diethyl maleate results in increased expression of GCLC mRNA; diethyl maleate results in increased expression of GCLC protein
CTD PMID:10915739, PMID:10978506, PMID:15115889, PMID:21465251, PMID:25270620 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression EXP
ISO
diethyl maleate results in increased expression of GCLM mRNA; diethyl maleate results in increased expression of GCLM protein CTD PMID:10978506, PMID:15115889, PMID:21465251, PMID:25270620 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Glul glutamate-ammonia ligase decreases expression ISO diethyl maleate results in decreased expression of GLUL mRNA CTD PMID:25270620 NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229
JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 decreases expression EXP diethyl maleate results in decreased expression of GOT2 protein CTD PMID:21161181 NCBI chr19:9,587,637...9,613,323
Ensembl chr19:9,587,653...9,613,340
JBrowse link
G Gpihbp1 glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 decreases expression ISO diethyl maleate results in decreased expression of GPIHBP1 mRNA CTD PMID:25270620 NCBI chr 7:116,632,496...116,635,543
Ensembl chr 7:116,632,506...116,634,293
JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 decreases expression EXP diethyl maleate results in decreased expression of GRIA3 mRNA CTD PMID:21161181 NCBI chr  X:127,561,843...127,829,763
Ensembl chr  X:127,562,660...127,829,753
JBrowse link
G Gsn gelsolin decreases reduction ISO diethyl maleate results in decreased reduction of GSN protein CTD PMID:19843705 NCBI chr 3:14,456,106...14,508,922
Ensembl chr 3:14,467,330...14,508,911
JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO diethyl maleate results in increased expression of GSR mRNA CTD PMID:25270620 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gss glutathione synthetase increases expression EXP diethyl maleate results in increased expression of GSS mRNA CTD PMID:10978506 NCBI chr 3:151,076,254...151,106,557
Ensembl chr 3:151,076,254...151,106,557
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression ISO diethyl maleate results in increased expression of GSTA2 mRNA CTD PMID:25270620 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta3 glutathione S-transferase alpha 3 increases expression EXP diethyl maleate results in increased expression of GSTA3 protein CTD PMID:9794803 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression EXP diethyl maleate results in increased expression of GSTA5 protein CTD PMID:9794803 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
JBrowse link
G Gsta6 glutathione S-transferase alpha 6 increases expression ISO diethyl maleate results in increased expression of GSTA2 mRNA CTD PMID:25270620 NCBI chr 9:27,475,273...27,533,939
Ensembl chr 9:27,475,273...27,511,176
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 multiple interactions ISO [diethyl maleate results in decreased abundance of Glutathione] which results in decreased expression of GSTK1 mRNA CTD PMID:22564015 NCBI chr 4:71,621,777...71,626,096
Ensembl chr 4:71,621,729...71,626,107
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression EXP diethyl maleate results in decreased expression of GSTM1 protein CTD PMID:21161181 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gsto1 glutathione S-transferase omega 1 increases expression ISO diethyl maleate results in increased expression of GSTO1 mRNA CTD PMID:25270620 NCBI chr 1:267,607,437...267,617,387
Ensembl chr 1:267,607,418...267,617,387
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP diethyl maleate results in increased expression of GSTP1 protein CTD PMID:9794803 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gstt1 glutathione S-transferase theta 1 increases expression EXP diethyl maleate results in increased expression of GSTT1 protein CTD PMID:9794803 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G Gtse1 G-2 and S-phase expressed 1 increases expression EXP diethyl maleate results in increased expression of GTSE1 mRNA CTD PMID:21161181 NCBI chr 7:126,736,416...126,753,221
Ensembl chr 7:126,736,732...126,753,220
JBrowse link
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) increases expression ISO diethyl maleate results in increased expression of H6PD mRNA CTD PMID:25270620 NCBI chr 5:166,994,683...167,030,441
Ensembl chr 5:166,998,881...167,030,441
JBrowse link
G Helb DNA helicase B decreases expression ISO diethyl maleate results in decreased expression of HELB mRNA CTD PMID:25270620 NCBI chr 7:64,860,641...64,888,146
Ensembl chr 7:64,860,666...64,887,448
JBrowse link
G Hes6 hes family bHLH transcription factor 6 decreases expression EXP diethyl maleate results in decreased expression of HES6 mRNA CTD PMID:21161181 NCBI chr 9:98,549,698...98,551,438
Ensembl chr 9:98,549,705...98,551,438
JBrowse link
G Hjurp Holliday junction recognition protein increases expression EXP diethyl maleate results in increased expression of HJURP mRNA CTD PMID:21161181 NCBI chr 9:95,347,739...95,362,228
Ensembl chr 9:95,349,086...95,362,014
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO diethyl maleate results in increased expression of HMOX1 mRNA CTD PMID:20491607, PMID:25270620 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 decreases reduction ISO diethyl maleate results in decreased reduction of HNRNPH1 protein CTD PMID:19843705 NCBI chr10:35,872,619...35,879,911
Ensembl chr10:35,870,232...35,879,910
JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 decreases expression EXP diethyl maleate results in decreased expression of HSD17B2 mRNA CTD PMID:21161181 NCBI chr19:50,246,404...50,317,892
Ensembl chr19:50,246,402...50,317,891
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases reduction ISO diethyl maleate results in decreased reduction of HSPA5 protein CTD PMID:19843705 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases reduction ISO diethyl maleate results in increased reduction of HSPA8 protein CTD PMID:19843705 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Htatip2 HIV-1 Tat interactive protein 2 increases expression ISO diethyl maleate results in increased expression of HTATIP2 mRNA CTD PMID:25270620 NCBI chr 1:105,094,272...105,109,459
Ensembl chr 1:105,094,411...105,109,461
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO diethyl maleate results in decreased expression of ICAM1 mRNA CTD PMID:25270620 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein decreases expression ISO diethyl maleate results in decreased expression of ID3 mRNA CTD PMID:25270620 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
JBrowse link
G Id4 inhibitor of DNA binding 4, HLH protein decreases expression ISO diethyl maleate results in decreased expression of ID4 mRNA CTD PMID:25270620 NCBI chr17:16,692,557...16,695,126
Ensembl chr17:16,692,557...16,695,126
JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 decreases expression EXP diethyl maleate results in decreased expression of IFIT3 mRNA CTD PMID:21161181 NCBI chr 1:252,906,234...252,911,377
Ensembl chr 1:252,906,234...252,911,382
JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon decreases expression ISO diethyl maleate results in decreased expression of IKBKE mRNA CTD PMID:25270620 NCBI chr13:48,031,325...48,056,394
Ensembl chr13:48,031,410...48,056,394
JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma increases expression ISO diethyl maleate results in increased expression of IKBKG mRNA CTD PMID:25270620 NCBI chr  X:156,254,187...156,280,046
Ensembl chr  X:156,257,173...156,270,748
JBrowse link
G Il10 interleukin 10 increases secretion ISO diethyl maleate results in increased secretion of IL10 protein CTD PMID:31958493 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il18 interleukin 18 increases expression ISO diethyl maleate results in increased expression of IL18 protein CTD PMID:23063874 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il4 interleukin 4 multiple interactions ISO [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein; [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein CTD PMID:31958493 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Inhbb inhibin subunit beta B decreases expression ISO diethyl maleate results in decreased expression of INHBB mRNA CTD PMID:25270620 NCBI chr13:35,436,532...35,442,222
Ensembl chr13:35,436,532...35,442,222
JBrowse link
G Inmt indolethylamine N-methyltransferase decreases expression EXP diethyl maleate results in decreased expression of INMT mRNA CTD PMID:21161181 NCBI chr 4:85,381,907...85,386,203
Ensembl chr 4:85,381,889...85,386,231
JBrowse link
G Ints7 integrator complex subunit 7 decreases expression ISO diethyl maleate results in decreased expression of INTS7 mRNA CTD PMID:25270620 NCBI chr13:110,257,571...110,310,413
Ensembl chr13:110,257,571...110,310,413
JBrowse link
G Irf7 interferon regulatory factor 7 decreases expression EXP diethyl maleate results in decreased expression of IRF7 mRNA CTD PMID:21161181 NCBI chr 1:214,249,388...214,252,909
Ensembl chr 1:214,248,837...214,252,456
JBrowse link
G Irf9 interferon regulatory factor 9 decreases expression EXP diethyl maleate results in decreased expression of IRF9 mRNA CTD PMID:21161181 NCBI chr15:34,282,936...34,288,981
Ensembl chr15:34,282,936...34,288,138
JBrowse link
G Irgm immunity-related GTPase M decreases expression EXP diethyl maleate results in decreased expression of IRGM mRNA CTD PMID:21161181 NCBI chr10:34,213,885...34,221,968
Ensembl chr10:34,213,936...34,221,928
JBrowse link
G Itgal integrin subunit alpha L decreases expression EXP diethyl maleate results in decreased expression of ITGAL mRNA CTD PMID:21161181 NCBI chr 1:198,744,053...198,781,745
Ensembl chr 1:198,744,050...198,781,750
JBrowse link
G Itih3 inter-alpha trypsin inhibitor, heavy chain 3 decreases expression ISO diethyl maleate results in decreased expression of ITIH3 mRNA CTD PMID:25270620 NCBI chr16:6,983,779...7,007,288
Ensembl chr16:6,992,062...7,007,287
JBrowse link
G Itih4 inter-alpha-trypsin inhibitor heavy chain 4 decreases expression ISO diethyl maleate results in decreased expression of ITIH4 mRNA CTD PMID:25270620 NCBI chr16:6,970,367...6,985,538
Ensembl chr16:6,970,342...6,985,579
JBrowse link
G Jam3 junctional adhesion molecule 3 decreases expression EXP diethyl maleate results in decreased expression of JAM3 mRNA CTD PMID:21161181 NCBI chr 8:28,147,110...28,208,466
Ensembl chr 8:28,147,111...28,208,466
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
increases phosphorylation
ISO pyrazolanthrone inhibits the reaction [TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]]; TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]
diethyl maleate results in increased expression of JUN mRNA
CTD PMID:10915739, PMID:12774022 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kcne3 potassium voltage-gated channel subfamily E regulatory subunit 3 decreases expression ISO diethyl maleate results in decreased expression of KCNE3 mRNA CTD PMID:25270620 NCBI chr 1:165,189,934...165,196,949
Ensembl chr 1:165,189,985...165,196,948
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases expression ISO diethyl maleate results in increased expression of KEAP1 protein CTD PMID:27358234 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Kifc1 kinesin family member C1 increases expression EXP diethyl maleate results in increased expression of KIFC1 mRNA CTD PMID:21161181 NCBI chr20:5,509,059...5,526,175
Ensembl chr20:5,509,059...5,526,175
JBrowse link
G Klf10 Kruppel-like factor 10 decreases expression EXP
ISO
diethyl maleate results in decreased expression of KLF10 mRNA CTD PMID:21161181, PMID:25270620 NCBI chr 7:77,156,010...77,162,096
Ensembl chr 7:77,156,006...77,162,148
JBrowse link
G Krt75 keratin 75 increases reduction ISO diethyl maleate results in increased reduction of KRT75 protein CTD PMID:19843705 NCBI chr 7:143,219,012...143,228,237
Ensembl chr 7:143,219,012...143,228,060
JBrowse link
G Lama1 laminin subunit alpha 1 decreases expression ISO diethyl maleate results in decreased expression of LAMA1 mRNA CTD PMID:25270620 NCBI chr 9:115,916,907...116,042,123
Ensembl chr 9:115,916,907...116,042,123
JBrowse link
G Lancl2 LanC like 2 decreases expression ISO diethyl maleate results in decreased expression of LANCL2 mRNA CTD PMID:25270620 NCBI chr 4:88,524,212...88,565,113
Ensembl chr 4:88,525,695...88,565,292
JBrowse link
G Ldlr low density lipoprotein receptor decreases expression EXP diethyl maleate results in decreased expression of LDLR mRNA CTD PMID:21161181 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Lepr leptin receptor decreases expression EXP diethyl maleate results in decreased expression of LEPR mRNA CTD PMID:21161181 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Lgals3bp galectin 3 binding protein decreases expression EXP diethyl maleate results in decreased expression of LGALS3BP mRNA CTD PMID:21161181 NCBI chr10:107,415,334...107,424,672
Ensembl chr10:107,415,326...107,424,710
JBrowse link
G Lmnb1 lamin B1 increases expression EXP diethyl maleate results in increased expression of LMNB1 mRNA CTD PMID:21161181 NCBI chr18:51,785,111...51,822,264
Ensembl chr18:51,785,111...51,822,264
JBrowse link
G Lmo7 LIM domain 7 decreases expression EXP diethyl maleate results in decreased expression of LMO7 mRNA CTD PMID:21161181 NCBI chr15:86,242,911...86,458,512
Ensembl chr15:86,243,148...86,457,739
JBrowse link
G LOC100363405 hypothetical LOC100363405 decreases expression EXP diethyl maleate results in decreased expression of ZFP37 mRNA CTD PMID:21161181 NCBI chr 5:77,265,335...77,294,739
Ensembl chr 5:77,266,842...77,294,765
JBrowse link
G Lrig3 leucine-rich repeats and immunoglobulin-like domains 3 decreases expression EXP diethyl maleate results in decreased expression of LRIG3 mRNA CTD PMID:21161181 NCBI chr 7:69,213,098...69,263,251
Ensembl chr 7:69,213,147...69,263,142
JBrowse link
G Lrrn4 leucine rich repeat neuronal 4 increases expression EXP diethyl maleate results in increased expression of LRRN4 mRNA CTD PMID:21161181 NCBI chr 3:125,521,879...125,547,685
Ensembl chr 3:125,523,781...125,533,600
JBrowse link
G Lrtm2 leucine-rich repeats and transmembrane domains 2 decreases expression EXP diethyl maleate results in decreased expression of LRTM2 mRNA CTD PMID:21161181 NCBI chr 4:151,375,568...151,397,485
Ensembl chr 4:151,375,572...151,390,263
JBrowse link
G Ltc4s leukotriene C4 synthase decreases expression EXP diethyl maleate results in decreased expression of LTC4S mRNA CTD PMID:21161181 NCBI chr10:35,736,486...35,743,088
Ensembl chr10:35,737,664...35,739,625
JBrowse link
G Lum lumican decreases expression EXP diethyl maleate results in decreased expression of LUM mRNA CTD PMID:21161181 NCBI chr 7:38,820,058...38,826,862
Ensembl chr 7:38,819,771...38,826,862
JBrowse link
G Ly6c Ly6-C antigen decreases expression EXP diethyl maleate results in decreased expression of LY6C mRNA CTD PMID:21161181
G Maff MAF bZIP transcription factor F increases expression ISO diethyl maleate results in increased expression of MAFF mRNA CTD PMID:20491607 NCBI chr 7:120,580,743...120,592,095
Ensembl chr 7:120,580,743...120,592,095
JBrowse link
G Maoa monoamine oxidase A increases expression ISO diethyl maleate results in increased expression of MAOA mRNA CTD PMID:25270620 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
G Marveld1 MARVEL domain containing 1 decreases expression EXP diethyl maleate results in decreased expression of MARVELD1 mRNA CTD PMID:21161181 NCBI chr 1:261,389,804...261,393,736
Ensembl chr 1:261,389,804...261,393,736
JBrowse link
G Mcm10 minichromosome maintenance 10 replication initiation factor increases expression EXP diethyl maleate results in increased expression of MCM10 mRNA CTD PMID:21161181 NCBI chr17:77,224,218...77,245,486
Ensembl chr17:77,224,112...77,246,478
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 increases expression EXP diethyl maleate results in increased expression of MCM4 mRNA CTD PMID:21161181 NCBI chr11:89,511,191...89,524,892
Ensembl chr11:89,511,191...89,524,892
JBrowse link
G Me1 malic enzyme 1 increases expression ISO diethyl maleate results in increased expression of ME1 mRNA CTD PMID:25270620 NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834
JBrowse link
G Mfap4 microfibril associated protein 4 decreases expression EXP diethyl maleate results in decreased expression of MFAP4 mRNA CTD PMID:21161181 NCBI chr10:47,765,463...47,768,484
Ensembl chr10:47,765,432...47,768,483
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases activity ISO diethyl maleate results in decreased activity of MGMT protein CTD PMID:16950796 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression EXP diethyl maleate results in increased expression of MKI67 mRNA CTD PMID:21161181 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mknk2 MAPK interacting serine/threonine kinase 2 decreases expression EXP diethyl maleate results in decreased expression of MKNK2 mRNA CTD PMID:21161181 NCBI chr 7:11,908,107...11,919,161
Ensembl chr 7:11,908,107...11,919,156
JBrowse link
G Mmp12 matrix metallopeptidase 12 increases expression ISO diethyl maleate results in increased expression of MMP12 mRNA CTD PMID:10216232 NCBI chr 8:5,594,717...5,616,494
Ensembl chr 8:5,606,592...5,616,493
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression EXP diethyl maleate results in decreased expression of MMP2 mRNA CTD PMID:21161181 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Msn moesin increases reduction ISO diethyl maleate results in increased reduction of MSN protein CTD PMID:19843705 NCBI chr  X:65,226,834...65,294,192
Ensembl chr  X:65,226,748...65,295,810
JBrowse link
G Mt1 metallothionein 1 increases expression ISO diethyl maleate results in increased expression of MT1A mRNA CTD PMID:20491607 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt2A metallothionein 2A increases expression ISO diethyl maleate results in increased expression of MT2A mRNA CTD PMID:20491607 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Mx2 MX dynamin like GTPase 2 decreases expression EXP diethyl maleate results in decreased expression of MX1 mRNA; diethyl maleate results in decreased expression of MX2 mRNA CTD PMID:21161181 NCBI chr11:38,035,306...38,066,185
Ensembl chr11:38,035,450...38,059,950
JBrowse link
G Mybl2 MYB proto-oncogene like 2 increases expression EXP diethyl maleate results in increased expression of MYBL2 mRNA CTD PMID:21161181 NCBI chr 3:159,421,638...159,450,087
Ensembl chr 3:159,421,671...159,450,086
JBrowse link
G Mycn MYCN proto-oncogene, bHLH transcription factor decreases expression ISO diethyl maleate results in decreased expression of MYCN mRNA CTD PMID:25270620 NCBI chr 6:38,222,554...38,228,419
Ensembl chr 6:38,222,555...38,228,379
JBrowse link
G Nat8 N-acetyltransferase 8 decreases expression EXP diethyl maleate results in decreased expression of NAT8 mRNA CTD PMID:21161181 NCBI chr 4:117,525,963...117,527,443 JBrowse link
G Ncaph non-SMC condensin I complex, subunit H increases expression EXP diethyl maleate results in increased expression of NCAPH mRNA CTD PMID:21161181 NCBI chr 3:119,583,798...119,611,148
Ensembl chr 3:119,583,648...119,611,136
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization
increases activity
increases expression
multiple interactions
decreases response to substance
ISO
EXP
diethyl maleate affects the localization of NFE2L2 protein
diethyl maleate results in increased activity of NFE2L2 protein
diethyl maleate results in increased expression of NFE2L2 protein
diethyl maleate binds to and results in increased activity of NFE2L2 protein; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]
NFE2L2 results in decreased susceptibility to diethyl maleate
NFE2L2 gene mutant form inhibits the reaction [diethyl maleate results in increased expression of SLC7A11 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 mRNA]
CTD PMID:12235164, PMID:20806931, PMID:21465251, PMID:22003191, PMID:27358234, PMID:27982581, PMID:30114225 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO diethyl maleate inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA] CTD PMID:12774022 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO
Acetylcysteine inhibits the reaction [diethyl maleate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; diethyl maleate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of diethyl maleate] CTD PMID:7532384, PMID:9918918, PMID:12774022 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO diethyl maleate results in increased expression of NQO1 mRNA CTD PMID:20491607, PMID:25270620 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression EXP diethyl maleate results in decreased expression of NR0B2 mRNA CTD PMID:21161181 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 decreases expression EXP diethyl maleate results in decreased expression of NR1D1 mRNA CTD PMID:21161181 NCBI chr10:86,683,875...86,690,815
Ensembl chr10:86,683,875...86,690,815
JBrowse link
G Nrep neuronal regeneration related protein decreases expression EXP diethyl maleate results in decreased expression of NREP mRNA CTD PMID:21161181 NCBI chr18:26,183,753...26,212,796
Ensembl chr18:26,185,259...26,211,445
JBrowse link
G Nsmf NMDA receptor synaptonuclear signaling and neuronal migration factor decreases expression ISO diethyl maleate results in decreased expression of NSMF mRNA CTD PMID:25270620 NCBI chr 3:2,262,173...2,270,996
Ensembl chr 3:2,262,253...2,270,995
JBrowse link
G Ntf3 neurotrophin 3 decreases expression EXP diethyl maleate results in decreased expression of NTF3 mRNA CTD PMID:21161181 NCBI chr 4:158,636,883...158,705,886
Ensembl chr 4:158,636,884...158,705,886
JBrowse link
G Nup153 nucleoporin 153 multiple interactions
affects localization
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP153 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP153 protein]; diethyl maleate results in increased phosphorylation of and results in increased O-linked glycosylation of NUP153 protein CTD PMID:20041180 NCBI chr17:18,358,712...18,411,368
Ensembl chr17:18,358,712...18,411,368
JBrowse link
G Nup88 nucleoporin 88 multiple interactions
affects localization
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP88 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP88 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] affects the reaction [diethyl maleate affects the localization of NUP88 protein]; diethyl maleate results in increased phosphorylation of and results in increased glycosylation of NUP88 protein CTD PMID:20041180 NCBI chr10:57,581,828...57,606,171
Ensembl chr10:57,581,828...57,606,171
JBrowse link
G Oaf out at first homolog decreases expression EXP diethyl maleate results in decreased expression of OAF mRNA CTD PMID:21161181 NCBI chr 8:47,511,718...47,529,689
Ensembl chr 8:47,511,719...47,529,689
JBrowse link
G Oas1i 2 ' -5 ' oligoadenylate synthetase 1I decreases expression EXP diethyl maleate results in decreased expression of OAS1I mRNA CTD PMID:21161181 NCBI chr12:41,155,489...41,167,501
Ensembl chr12:41,155,497...41,167,505
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions ISO [diethyl maleate results in decreased abundance of Glutathione] which results in increased expression of OGG1 mRNA CTD PMID:22564015 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
JBrowse link
G Orc1 origin recognition complex, subunit 1 increases expression EXP diethyl maleate results in increased expression of ORC1 mRNA CTD PMID:21161181 NCBI chr 5:128,186,651...128,212,901
Ensembl chr 5:128,190,708...128,210,445
JBrowse link
G P2rx7 purinergic receptor P2X 7 decreases expression EXP diethyl maleate results in decreased expression of P2RX7 mRNA CTD PMID:21161181 NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO diethyl maleate results in increased cleavage of PARP1 protein CTD PMID:21105742 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pbld1 phenazine biosynthesis-like protein domain containing 1 decreases expression EXP diethyl maleate results in decreased expression of PBLD protein CTD PMID:21161181 NCBI chr20:27,103,300...27,118,650
Ensembl chr20:27,103,317...27,117,663
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO diethyl maleate results in decreased expression of PCNA mRNA CTD PMID:11875189 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pdlim2 PDZ and LIM domain 2 decreases expression EXP diethyl maleate results in decreased expression of PDLIM2 mRNA CTD PMID:21161181 NCBI chr15:51,843,562...51,856,785
Ensembl chr15:51,843,564...51,855,325
JBrowse link
G Pdrg1 p53 and DNA damage regulated 1 increases expression ISO diethyl maleate results in increased expression of PDRG1 mRNA CTD PMID:25270620 NCBI chr 3:148,487,056...148,493,225
Ensembl chr 3:148,487,059...148,493,225
JBrowse link
G Per2 period circadian regulator 2 decreases expression EXP diethyl maleate results in decreased expression of PER2 mRNA CTD PMID:21161181 NCBI chr 9:98,555,154...98,597,362
Ensembl chr 9:98,555,169...98,597,359
JBrowse link
G Per3 period circadian regulator 3 decreases expression EXP diethyl maleate results in decreased expression of PER3 mRNA CTD PMID:21161181 NCBI chr 5:168,088,126...168,123,482
Ensembl chr 5:168,086,998...168,123,395
JBrowse link
G Pgd phosphogluconate dehydrogenase increases activity EXP diethyl maleate results in increased activity of PGD protein CTD PMID:3099627 NCBI chr 5:165,966,128...165,982,327 JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 increases expression ISO diethyl maleate results in increased expression of PGRMC1 mRNA CTD PMID:25270620 NCBI chr  X:123,205,869...123,213,880
Ensembl chr  X:123,205,869...123,213,882
JBrowse link
G Pir pirin increases expression ISO diethyl maleate results in increased expression of PIR mRNA CTD PMID:25270620 NCBI chr  X:31,852,322...31,968,152
Ensembl chr  X:31,852,323...31,968,152
JBrowse link
G Pklr pyruvate kinase L/R decreases expression EXP diethyl maleate results in decreased expression of PKLR mRNA CTD PMID:21161181 NCBI chr 2:188,449,158...188,458,034
Ensembl chr 2:188,449,210...188,459,592
JBrowse link
G Plat plasminogen activator, tissue type increases expression
decreases expression
EXP
ISO
diethyl maleate results in increased expression of PLAT mRNA
diethyl maleate results in decreased expression of PLAT mRNA
CTD PMID:21161181, PMID:25270620 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Plek pleckstrin decreases expression EXP diethyl maleate results in decreased expression of PLEK mRNA CTD PMID:21161181 NCBI chr14:100,151,518...100,184,192
Ensembl chr14:100,151,210...100,217,913
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
decreases activity
EXP diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]; resveratrol inhibits the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]; resveratrol inhibits the reaction [diethyl maleate results in decreased activity of PPARA protein]; resveratrol promotes the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]; resveratrol promotes the reaction [diethyl maleate results in decreased activity of PPARA protein] CTD PMID:17134953 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppargc1b PPARG coactivator 1 beta decreases expression EXP diethyl maleate results in decreased expression of PPARGC1B mRNA CTD PMID:21161181 NCBI chr18:56,626,725...56,650,524
Ensembl chr18:56,626,712...56,728,968
JBrowse link
G Ppp1r3b protein phosphatase 1, regulatory subunit 3B decreases expression EXP diethyl maleate results in decreased expression of PPP1R3B mRNA CTD PMID:21161181 NCBI chr16:60,415,192...60,427,498
Ensembl chr16:60,415,229...60,427,474
JBrowse link
G Ppp1r3c protein phosphatase 1, regulatory subunit 3C decreases expression EXP diethyl maleate results in decreased expression of PPP1R3C mRNA CTD PMID:21161181 NCBI chr 1:255,371,830...255,376,833
Ensembl chr 1:255,371,810...255,376,833
JBrowse link
G Prdm14 PR/SET domain 14 decreases expression ISO diethyl maleate results in decreased expression of PRDM14 mRNA CTD PMID:25270620 NCBI chr 5:5,710,076...5,730,560
Ensembl chr 5:5,710,392...5,730,560
JBrowse link
G Prdx1 peroxiredoxin 1 increases expression EXP
ISO
diethyl maleate results in increased expression of PRDX1 mRNA CTD PMID:9506838 NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990
JBrowse link
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 decreases expression ISO diethyl maleate results in decreased expression of PRKAB1 mRNA CTD PMID:25270620 NCBI chr12:46,316,298...46,326,789
Ensembl chr12:46,316,236...46,326,790
JBrowse link
G Prkcb protein kinase C, beta affects expression ISO diethyl maleate affects the expression of PRKCB protein CTD PMID:31958493 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Prkcd protein kinase C, delta multiple interactions EXP Cycloheximide inhibits the reaction [diethyl maleate results in increased expression of PRKCD protein]; diethyl maleate results in increased expression of and results in increased activity of PRKCD protein CTD PMID:11118818 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prkce protein kinase C, epsilon multiple interactions EXP Cycloheximide inhibits the reaction [diethyl maleate results in increased expression of PRKCE protein]; diethyl maleate results in increased expression of and results in increased activity of PRKCE protein CTD PMID:11118818 NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396
JBrowse link
G Prss8 serine protease 8 decreases expression EXP diethyl maleate results in decreased expression of PRSS8 mRNA CTD PMID:21161181 NCBI chr 1:199,372,519...199,377,035
Ensembl chr 1:199,372,519...199,377,035
JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression ISO diethyl maleate results in increased expression of PTGR1 mRNA CTD PMID:25270620 NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441
JBrowse link
G Ptpn14 protein tyrosine phosphatase, non-receptor type 14 increases expression ISO diethyl maleate results in increased expression of PTPN14 mRNA CTD PMID:25270620 NCBI chr13:108,689,916...108,841,593
Ensembl chr13:108,696,336...108,841,511
JBrowse link
G Pus1 pseudouridine synthase 1 decreases expression ISO diethyl maleate results in decreased expression of PUS1 mRNA CTD PMID:25270620 NCBI chr12:51,936,721...51,945,930
Ensembl chr12:51,937,175...51,945,928
JBrowse link
G Rab27a RAB27A, member RAS oncogene family decreases expression EXP diethyl maleate results in decreased expression of RAB27A mRNA CTD PMID:21161181 NCBI chr 8:79,722,334...79,776,228
Ensembl chr 8:79,722,334...79,776,221
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO diethyl maleate inhibits the reaction [[carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] which results in increased glutathionylation of RELA protein]; diethyl maleate inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] CTD PMID:20116392 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rnf114 ring finger protein 114 decreases expression ISO diethyl maleate results in decreased expression of RNF114 mRNA CTD PMID:25270620 NCBI chr 3:164,248,736...164,260,499
Ensembl chr 3:164,248,731...164,260,497
JBrowse link
G Rnf14 ring finger protein 14 increases expression ISO diethyl maleate results in increased expression of RNF14 mRNA CTD PMID:25270620 NCBI chr18:31,443,424...31,468,641
Ensembl chr18:31,444,472...31,468,640
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 increases expression EXP diethyl maleate results in increased expression of RRM2 mRNA CTD PMID:21161181 NCBI chr 6:43,884,627...43,890,818
Ensembl chr 6:43,884,678...43,889,515
JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 decreases expression EXP diethyl maleate results in decreased expression of RSAD2 mRNA CTD PMID:21161181 NCBI chr 6:45,655,947...45,669,083
Ensembl chr 6:45,655,954...45,669,148
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 decreases expression EXP diethyl maleate results in decreased expression of RT1-S3 mRNA CTD PMID:21161181 NCBI chr20:3,176,124...3,180,825
Ensembl chr20:3,176,107...3,179,818
JBrowse link
G S100a9 S100 calcium binding protein A9 decreases expression EXP diethyl maleate results in decreased expression of S100A9 mRNA CTD PMID:21161181 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
G Sash3 SAM and SH3 domain containing 3 decreases expression EXP diethyl maleate results in decreased expression of SASH3 mRNA CTD PMID:21161181 NCBI chr  X:134,979,637...134,994,351
Ensembl chr  X:134,979,646...134,994,349
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression EXP diethyl maleate results in decreased expression of SCD1 mRNA CTD PMID:21161181 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Sds serine dehydratase decreases expression EXP diethyl maleate results in decreased expression of SDS mRNA CTD PMID:21161181 NCBI chr12:41,620,429...41,627,741
Ensembl chr12:41,620,393...41,627,741
JBrowse link
G Serpind1 serpin family D member 1 decreases expression ISO diethyl maleate results in decreased expression of SERPIND1 mRNA CTD PMID:25270620 NCBI chr11:87,913,814...87,924,880
Ensembl chr11:87,913,806...87,924,816
JBrowse link
G Sez6 seizure related 6 homolog decreases expression EXP diethyl maleate results in decreased expression of SEZ6 mRNA CTD PMID:21161181 NCBI chr10:64,865,802...64,915,461
Ensembl chr10:64,865,805...64,915,148
JBrowse link
G Sfxn1 sideroflexin 1 decreases expression ISO diethyl maleate results in decreased expression of SFXN1 mRNA CTD PMID:25270620 NCBI chr17:11,046,588...11,082,219
Ensembl chr17:11,045,761...11,082,047
JBrowse link
G Six4 SIX homeobox 4 increases expression ISO diethyl maleate results in increased expression of SIX4 mRNA CTD PMID:25270620 NCBI chr 6:95,984,868...95,999,709
Ensembl chr 6:95,984,868...95,998,529
JBrowse link
G Slc16a6 solute carrier family 16, member 6 decreases expression ISO diethyl maleate results in decreased expression of SLC16A6 mRNA CTD PMID:25270620 NCBI chr10:97,733,701...97,758,723
Ensembl chr10:97,735,548...97,756,521
JBrowse link
G Slc1a4 solute carrier family 1 member 4 increases expression ISO diethyl maleate results in increased expression of SLC1A4 mRNA CTD PMID:25270620 NCBI chr14:104,582,884...104,612,417
Ensembl chr14:104,581,190...104,612,597
JBrowse link
G Slc2a2 solute carrier family 2 member 2 decreases expression EXP diethyl maleate results in decreased expression of SLC2A2 mRNA CTD PMID:21161181 NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395
JBrowse link
G Slc2a5 solute carrier family 2 member 5 decreases expression EXP diethyl maleate results in decreased expression of SLC2A5 mRNA CTD PMID:21161181 NCBI chr 5:167,142,182...167,174,203
Ensembl chr 5:167,141,875...167,174,310
JBrowse link
G Slc39a14 solute carrier family 39 member 14 decreases expression ISO diethyl maleate results in decreased expression of SLC39A14 mRNA CTD PMID:25270620 NCBI chr15:51,982,872...52,029,841
Ensembl chr15:51,982,982...52,029,816
JBrowse link
G Slc40a1 solute carrier family 40 member 1 multiple interactions ISO diethyl maleate inhibits the reaction [Lipopolysaccharides results in decreased expression of SLC40A1 mRNA] CTD PMID:21303654 NCBI chr 9:52,819,451...52,830,461
Ensembl chr 9:52,894,365...52,912,293
JBrowse link
G Slc44a4 solute carrier family 44, member 4 decreases expression EXP diethyl maleate results in decreased expression of SLC44A4 mRNA CTD PMID:21161181 NCBI chr20:4,593,389...4,609,641
Ensembl chr20:4,593,389...4,609,631
JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions
increases expression
ISO NFE2L2 gene mutant form inhibits the reaction [diethyl maleate results in increased expression of SLC7A11 mRNA] CTD PMID:12235164 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Slc9a3r1 SLC9A3 regulator 1 decreases expression EXP diethyl maleate results in decreased expression of SLC9A3R1 mRNA CTD PMID:21161181 NCBI chr10:103,713,045...103,730,145
Ensembl chr10:103,713,045...103,730,145
JBrowse link
G Slco2a1 solute carrier organic anion transporter family, member 2a1 decreases expression EXP diethyl maleate results in decreased expression of SLCO2A1 mRNA CTD PMID:21161181 NCBI chr 8:111,495,443...111,577,320
Ensembl chr 8:111,495,331...111,577,833
JBrowse link
G Slfn3 schlafen family member 3 decreases expression EXP diethyl maleate results in decreased expression of SLFN3 mRNA CTD PMID:21161181 NCBI chr10:70,438,012...70,477,259 JBrowse link
G Smc4 structural maintenance of chromosomes 4 increases expression EXP diethyl maleate results in increased expression of SMC4 mRNA CTD PMID:21161181 NCBI chr 2:165,600,934...165,629,415
Ensembl chr 2:165,601,007...165,629,415
JBrowse link
G Smtn smoothelin increases expression EXP diethyl maleate results in increased expression of SMTN mRNA CTD PMID:21161181 NCBI chr14:83,755,141...83,776,871
Ensembl chr14:83,755,142...83,776,863
JBrowse link
G Socs3 suppressor of cytokine signaling 3 decreases expression ISO diethyl maleate results in decreased expression of SOCS3 mRNA CTD PMID:25270620 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sorl1 sortilin related receptor 1 decreases expression EXP diethyl maleate results in decreased expression of SORL1 mRNA CTD PMID:21161181 NCBI chr 8:46,228,077...46,287,171 JBrowse link
G Sox9 SRY-box transcription factor 9 increases expression EXP diethyl maleate results in increased expression of SOX9 mRNA CTD PMID:21161181 NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379
JBrowse link
G Sp5 Sp5 transcription factor decreases expression ISO diethyl maleate results in decreased expression of SP5 mRNA CTD PMID:25270620 NCBI chr 3:56,766,475...56,769,277
Ensembl chr 3:56,766,475...56,769,277
JBrowse link
G Spc25 SPC25 component of NDC80 kinetochore complex increases expression EXP diethyl maleate results in increased expression of SPC25 mRNA CTD PMID:21161181 NCBI chr 3:55,438,534...55,451,961
Ensembl chr 3:55,438,536...55,451,798
JBrowse link
G Spta1 spectrin, alpha, erythrocytic 1 increases expression ISO diethyl maleate results in increased expression of SPTA1 mRNA CTD PMID:25270620 NCBI chr13:92,264,231...92,340,091
Ensembl chr13:92,264,231...92,340,083
JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 increases cleavage ISO diethyl maleate results in increased cleavage of SPTAN1 protein CTD PMID:21105742 NCBI chr 3:8,534,437...8,599,259
Ensembl chr 3:8,534,440...8,599,260
JBrowse link
G Sptbn4 spectrin, beta, non-erythrocytic 4 increases expression ISO diethyl maleate results in increased expression of SPTBN4 mRNA CTD PMID:25270620 NCBI chr 1:84,168,494...84,254,679
Ensembl chr 1:84,168,495...84,254,645
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO diethyl maleate results in increased expression of SQSTM1 mRNA CTD PMID:25270620 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression EXP diethyl maleate results in decreased expression of SREBF1 mRNA CTD PMID:21161181 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Srxn1 sulfiredoxin 1 multiple interactions
increases expression
ISO [Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [diethyl maleate results in increased expression of SRXN1 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 mRNA]
NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]; TP53 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]
diethyl maleate results in increased expression of SRXN1 mRNA; diethyl maleate results in increased expression of SRXN1 protein
CTD PMID:22003191, PMID:25270620, PMID:27358234, PMID:27982581 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression EXP diethyl maleate results in decreased expression of STAT1 mRNA CTD PMID:21161181 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Steap4 STEAP4 metalloreductase decreases expression ISO diethyl maleate results in decreased expression of STEAP4 mRNA CTD PMID:25270620 NCBI chr 4:23,112,682...23,135,354
Ensembl chr 4:23,090,029...23,135,354
JBrowse link
G Sulf2 sulfatase 2 decreases expression EXP diethyl maleate results in decreased expression of SULF2 mRNA CTD PMID:21161181 NCBI chr 3:162,791,349...162,872,984
Ensembl chr 3:162,791,355...162,872,831
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases expression EXP diethyl maleate results in decreased expression of SULT1A1 protein CTD PMID:21161181 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Tagln transgelin decreases expression EXP diethyl maleate results in decreased expression of TAGLN mRNA CTD PMID:21161181 NCBI chr 8:50,222,895...50,228,369
Ensembl chr 8:50,222,896...50,231,357
JBrowse link
G Tbcel tubulin folding cofactor E-like increases expression ISO diethyl maleate results in increased expression of TBCEL mRNA CTD PMID:25270620 NCBI chr 8:46,691,488...46,750,816
Ensembl chr 8:46,694,561...46,750,898
JBrowse link
G Tent5a terminal nucleotidyltransferase 5A decreases expression EXP diethyl maleate results in decreased expression of TENT5A mRNA CTD PMID:21161181 NCBI chr 8:92,935,474...92,942,267
Ensembl chr 8:92,937,739...92,942,076
JBrowse link
G Tesmin testis expressed metallothionein like protein affects localization ISO diethyl maleate affects the localization of TESMIN protein CTD PMID:12606435 NCBI chr 1:218,632,764...218,651,054
Ensembl chr 1:218,632,764...218,651,053
JBrowse link
G Tf transferrin decreases expression EXP diethyl maleate results in decreased expression of TF protein CTD PMID:21161181 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Tfeb transcription factor EB decreases expression ISO diethyl maleate results in decreased expression of TFEB mRNA CTD PMID:25270620 NCBI chr 9:15,208,141...15,264,101
Ensembl chr 9:15,207,822...15,214,596
JBrowse link
G Tgm2 transglutaminase 2 increases expression EXP diethyl maleate results in increased expression of TGM2 mRNA CTD PMID:21161181 NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257
JBrowse link
G Thbs1 thrombospondin 1 increases expression EXP diethyl maleate results in increased expression of THBS1 mRNA CTD PMID:21161181 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Thrsp thyroid hormone responsive decreases expression EXP diethyl maleate results in decreased expression of THRSP mRNA CTD PMID:21161181 NCBI chr 1:162,381,251...162,385,575
Ensembl chr 1:162,381,253...162,385,575
JBrowse link
G Tm4sf1 transmembrane 4 L six family member 1 increases expression EXP diethyl maleate results in increased expression of TM4SF1 mRNA CTD PMID:21161181 NCBI chr 2:147,382,866...147,392,062
Ensembl chr 2:147,382,866...147,392,062
JBrowse link
G Tmem209 transmembrane protein 209 increases expression ISO diethyl maleate results in increased expression of TMEM209 mRNA CTD PMID:25270620 NCBI chr 4:57,796,337...57,823,283
Ensembl chr 4:57,796,338...57,823,295
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
[diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein; [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein; diethyl maleate inhibits the reaction [[carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] which results in increased glutathionylation of RELA protein]; diethyl maleate inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 protein]
diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of diethyl maleate]
diethyl maleate inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]]; TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]
CTD PMID:7476933, PMID:7532384, PMID:12774022, PMID:20116392, PMID:31958493 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf14 TNF receptor superfamily member 14 decreases expression EXP diethyl maleate results in decreased expression of TNFRSF14 mRNA CTD PMID:21161181 NCBI chr 5:172,328,259...172,337,221
Ensembl chr 5:172,328,262...172,335,892
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO TRP53 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]
TP53 protein affects the reaction [diethyl maleate results in increased expression of CDKN1A protein]; TP53 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]
CTD PMID:22003191, PMID:27982581 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tpm2 tropomyosin 2 decreases expression EXP diethyl maleate results in decreased expression of TPM2 mRNA CTD PMID:21161181 NCBI chr 5:59,016,616...59,025,971
Ensembl chr 5:59,016,622...59,025,631
JBrowse link
G Trap1 TNF receptor-associated protein 1 multiple interactions
decreases response to substance
ISO diethyl maleate inhibits the reaction [Cisplatin results in decreased expression of TRAP1 protein]
TRAP1 protein results in decreased susceptibility to diethyl maleate
CTD PMID:17853063 NCBI chr10:11,724,032...11,757,682
Ensembl chr10:11,724,032...11,757,681
JBrowse link
G Trdmt1 tRNA aspartic acid methyltransferase 1 decreases expression ISO diethyl maleate results in decreased expression of TRDMT1 mRNA CTD PMID:25270620 NCBI chr17:80,824,652...80,859,585
Ensembl chr17:80,826,846...80,860,195
JBrowse link
G Trim6 tripartite motif containing 6 decreases expression EXP diethyl maleate results in decreased expression of TRIM6 mRNA CTD PMID:21161181 NCBI chr 1:169,410,084...169,423,305
Ensembl chr 1:169,410,115...169,423,283
JBrowse link
G Trip13 thyroid hormone receptor interactor 13 increases expression EXP diethyl maleate results in increased expression of TRIP13 mRNA CTD PMID:21161181 NCBI chr 1:31,967,980...32,012,923
Ensembl chr 1:31,967,978...32,012,919
JBrowse link
G Tsc22d1 TSC22 domain family, member 1 decreases expression EXP diethyl maleate results in decreased expression of TSC22D1 mRNA CTD PMID:21161181 NCBI chr15:58,554,358...58,658,156
Ensembl chr15:58,554,374...58,658,153
JBrowse link
G Tspan8 tetraspanin 8 decreases expression EXP diethyl maleate results in decreased expression of TSPAN8 mRNA CTD PMID:21161181 NCBI chr 7:58,814,805...58,847,564
Ensembl chr 7:58,814,805...58,847,563
JBrowse link
G Tstd1 thiosulfate sulfurtransferase like domain containing 1 decreases expression ISO diethyl maleate results in decreased expression of TSTD1 mRNA CTD PMID:25270620 NCBI chr13:89,805,652...89,807,355
Ensembl chr13:89,805,962...89,807,243
JBrowse link
G Txn1 thioredoxin 1 decreases activity ISO diethyl maleate results in decreased activity of TXN protein CTD PMID:15388247 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Txnip thioredoxin interacting protein increases expression EXP diethyl maleate results in increased expression of TXNIP mRNA CTD PMID:21161181 NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO diethyl maleate results in increased expression of TXNRD1 mRNA CTD PMID:15521073 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Ubd ubiquitin D decreases expression EXP diethyl maleate results in decreased expression of UBD mRNA CTD PMID:21161181 NCBI chr20:1,876,175...1,878,126
Ensembl chr20:1,876,173...1,897,814
JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 increases expression EXP diethyl maleate results in increased expression of UHRF1 mRNA CTD PMID:21161181 NCBI chr 9:10,738,211...10,758,403
Ensembl chr 9:10,738,222...10,757,954
JBrowse link
G Usp18 ubiquitin specific peptidase 18 decreases expression EXP diethyl maleate results in decreased expression of USP18 mRNA CTD PMID:21161181 NCBI chr 4:153,812,312...153,834,374
Ensembl chr 4:153,805,993...153,834,430
JBrowse link
G Usp2 ubiquitin specific peptidase 2 decreases expression EXP diethyl maleate results in decreased expression of USP2 mRNA CTD PMID:21161181 NCBI chr 8:48,403,985...48,432,525
Ensembl chr 8:48,406,260...48,430,885
JBrowse link
G Wdr31 WD repeat domain 31 decreases expression ISO diethyl maleate results in decreased expression of WDR31 mRNA CTD PMID:25270620 NCBI chr 5:78,305,526...78,324,318
Ensembl chr 5:78,305,526...78,324,278
JBrowse link
G Wdr6 WD repeat domain 6 decreases expression EXP diethyl maleate results in decreased expression of WDR6 mRNA CTD PMID:21161181 NCBI chr 8:117,358,345...117,364,761
Ensembl chr 8:117,358,787...117,366,096
JBrowse link
G Ypel5 yippee-like 5 increases expression ISO diethyl maleate results in increased expression of YPEL5 mRNA CTD PMID:25270620 NCBI chr 6:24,069,351...24,084,758
Ensembl chr 6:24,064,738...24,084,757
JBrowse link
G Zfp36 zinc finger protein 36 increases expression ISO diethyl maleate results in increased expression of ZFP36 protein CTD PMID:21969073 NCBI chr 1:85,380,088...85,382,565
Ensembl chr 1:85,380,088...85,382,569
JBrowse link
G Zfp367 zinc finger protein 367 increases expression EXP diethyl maleate results in increased expression of ZNF367 mRNA CTD PMID:21161181 NCBI chr17:1,652,892...1,672,021
Ensembl chr17:1,652,895...1,672,021
JBrowse link
G Znrd2 zinc ribbon domain containing 2 decreases expression ISO diethyl maleate results in decreased expression of ZNRD2 mRNA CTD PMID:25270620 NCBI chr 1:221,087,803...221,089,586
Ensembl chr 1:221,087,803...221,089,586
JBrowse link
dimethyl fumarate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Dimethyl Fumarate inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:30703375 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 multiple interactions ISO Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of ATP6V0D2 mRNA] CTD PMID:30742845 NCBI chr 5:33,843,591...33,892,446
Ensembl chr 5:33,843,519...33,892,462
JBrowse link
G Bach1 BTB domain and CNC homolog 1 affects localization ISO Dimethyl Fumarate affects the localization of BACH1 protein CTD PMID:27277809 NCBI chr11:27,364,913...27,398,713
Ensembl chr11:27,364,916...27,398,842
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dimethyl Fumarate inhibits the reaction [IKBKB protein results in increased expression of CCL2 mRNA]; Dimethyl Fumarate inhibits the reaction [TNF protein promotes the reaction [RELA protein binds to CCL2 promoter]]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]
Dimethyl Fumarate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCL2 mRNA]
Dimethyl Fumarate results in decreased expression of CCL2 mRNA
CTD PMID:26683377, PMID:27277809 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cd68 Cd68 molecule multiple interactions ISO Dimethyl Fumarate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CD68 mRNA] CTD PMID:27277809 NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640
JBrowse link
G Csf1r colony stimulating factor 1 receptor multiple interactions ISO Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of ATP6V0D2 mRNA]; Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of CTSK mRNA] CTD PMID:30742845 NCBI chr18:56,414,493...56,458,300
Ensembl chr18:56,414,488...56,458,300
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G Ctsk cathepsin K multiple interactions ISO Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of CTSK mRNA] CTD PMID:30742845 NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446
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G Fth1 ferritin heavy chain 1 increases expression
multiple interactions
ISO Dimethyl Fumarate results in increased expression of FTH1 mRNA; Dimethyl Fumarate results in increased expression of FTH1 protein
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTH1 mRNA]
CTD PMID:28289076 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
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G Ftl1 ferritin light chain 1 increases expression
multiple interactions
ISO Dimethyl Fumarate results in increased expression of FTL mRNA; Dimethyl Fumarate results in increased expression of FTL protein
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTL mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTL protein]
CTD PMID:28289076 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
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G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
ISO
EXP
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GCLC mRNA]
Dimethyl Fumarate results in increased expression of GCLC protein
CTD PMID:27277809, PMID:30248482 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
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G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
increases expression
ISO
EXP
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GCLM mRNA]
Dimethyl Fumarate results in increased expression of GCLM protein
CTD PMID:27277809 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
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G Gpx4 glutathione peroxidase 4 increases metabolic processing ISO Dimethyl Fumarate results in increased metabolism of GPX4 protein CTD PMID:29917289 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
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G Gsr glutathione-disulfide reductase increases expression
multiple interactions
EXP
ISO
Dimethyl Fumarate results in increased expression of GSR protein
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GSR mRNA]
CTD PMID:27277809 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
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G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO
EXP
Dimethyl Fumarate results in increased expression of HMOX1 mRNA; Dimethyl Fumarate results in increased expression of HMOX1 protein
Acetylcysteine inhibits the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]; HMOX1 protein inhibits the reaction [Dimethyl Fumarate inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]
[Dimethyl Fumarate results in decreased abundance of Glutathione] which results in increased expression of HMOX1 protein; [Dimethyl Fumarate results in increased expression of HMOX1 protein] which results in decreased susceptibility to PDGFB protein; Glutathione inhibits the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]
CTD PMID:20961405, PMID:23942037, PMID:26683377, PMID:27277809, PMID:28790194, PMID:29950142 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14