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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dimethoxybenzene
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Accession:CHEBI:51681 term browser browse the term
Definition:Any methoxybenzene that consists of a benzene skeleton substituted with two methoxy groups and its derivatives.
Synonyms:related_synonym: dimethoxybenzenes


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2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases activity ISO 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased activity of ABCB1 protein CTD PMID:23273999 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases activity ISO 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased activity of ABCG2 protein CTD PMID:30083819 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Adcyap1 adenylate cyclase activating polypeptide 1 multiple interactions
increases response to substance
ISO ADCYAP1 gene mutant form promotes the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of FOS protein]
ADCYAP1 gene mutant form results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine
CTD PMID:24586556 NCBI chr 9:121,705,897...121,725,736
Ensembl chr 9:121,706,979...121,725,716
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression EXP 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of AIFM1 protein CTD PMID:22983118 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
increases expression
ISO [Poly I-C results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine] which results in increased expression of BDNF mRNA; Poly I-C promotes the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of BDNF mRNA] CTD PMID:24889602 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Casp3 caspase 3 increases activity EXP 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased activity of CASP3 protein CTD PMID:22983118 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity EXP 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased activity of CASP8 protein CTD PMID:22983118 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cycs cytochrome c, somatic affects localization EXP 4-iodo-2,5-dimethoxyphenylisopropylamine affects the localization of CYCS protein CTD PMID:22983118 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Egr1 early growth response 1 increases expression
multiple interactions
ISO 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of EGR1 mRNA
[Poly I-C results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine] which results in increased expression of EGR1 mRNA; Poly I-C promotes the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of EGR1 mRNA]
CTD PMID:24889602 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
EXP
ISO
4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of FOS protein
ADCYAP1 gene mutant form promotes the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of FOS protein]
CTD PMID:12482207, PMID:24586556 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions
affects binding
affects response to substance
increases response to substance
decreases response to substance
increases activity
ISO
EXP
[Alprenolol co-treated with Cocaine] affects the reaction [HTR2A protein results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine]; [Yohimbine co-treated with Cocaine] affects the reaction [HTR2A protein results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine]; Cocaine inhibits the reaction [HTR2A protein results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine]
4-iodo-2,5-dimethoxyphenylisopropylamine binds to HTR2A protein
HTR2A protein affects the susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine
4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein; [4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein] which results in increased secretion of and results in increased abundance of Dopamine; Cocaine promotes the reaction [[4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein] which results in increased secretion of and results in increased abundance of Dopamine]; Ketanserin inhibits the reaction [[4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein] which results in increased secretion of and results in increased abundance of Dopamine]; Ketanserin inhibits the reaction [Cocaine promotes the reaction [[4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein] which results in increased secretion of and results in increased abundance of Dopamine]]; Streptozocin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased activity of HTR2A protein]
1-(8-bromobenzo(1,2-b;4,5-b')difuran-4-yl)-2-aminopropane inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine binds to HTR2A protein]; 4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein
HTR2A gene SNP results in decreased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine
CTD PMID:8392199, PMID:9857084, PMID:10773215, PMID:12482207, PMID:16314884, PMID:18622176, PMID:22983118 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C multiple interactions
affects binding
ISO 1-(8-bromobenzo(1,2-b;4,5-b')difuran-4-yl)-2-aminopropane inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine binds to HTR2C protein] CTD PMID:9857084 NCBI chr  X:118,084,520...118,318,040
Ensembl chr  X:118,084,890...118,318,039
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
EXP 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of IL1B protein
4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of and results in increased secretion of IL1B protein; gastrodin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of IL1B protein]; rhyncophylline inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of and results in increased secretion of IL1B protein]; Tiapride Hydrochloride inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of and results in increased secretion of IL1B protein]; Tiapride Hydrochloride inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of IL1B protein]
CTD PMID:30790395, PMID:31231976 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
EXP 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of IL6 protein
4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of and results in increased secretion of IL6 protein; gastrodin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of IL6 protein]; rhyncophylline inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of and results in increased secretion of IL6 protein]; Tiapride Hydrochloride inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of and results in increased secretion of IL6 protein]; Tiapride Hydrochloride inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of IL6 protein]
CTD PMID:30790395, PMID:31231976 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jak2 Janus kinase 2 increases phosphorylation
multiple interactions
EXP 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of JAK2 protein
rhyncophylline inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of JAK2 protein]; Tiapride Hydrochloride inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of JAK2 protein]
CTD PMID:31231976 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
EXP 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of MAPK1 protein
Tiapride Hydrochloride inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of MAPK1 protein]
CTD PMID:30790395 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
EXP 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of MAPK3 protein
Tiapride Hydrochloride inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of MAPK3 protein]
CTD PMID:30790395 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
EXP 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of MAPK8 protein
gastrodin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of MAPK8 protein]; Tiapride Hydrochloride inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of MAPK8 protein]
CTD PMID:30790395 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions
increases expression
EXP gastrodin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of MYD88 protein]; Tiapride Hydrochloride inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of MYD88 protein] CTD PMID:30790395 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation
multiple interactions
EXP 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of NFKBIA protein
rhyncophylline inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of NFKBIA protein]; Tiapride Hydrochloride inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of NFKBIA protein]
CTD PMID:31231976 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos1 nitric oxide synthase 1 increases expression EXP 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of NOS1 protein CTD PMID:12482207 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Pdyn prodynorphin decreases expression EXP 4-iodo-2,5-dimethoxyphenylisopropylamine results in decreased expression of PDYN mRNA CTD PMID:9526047 NCBI chr 3:122,194,327...122,206,671
Ensembl chr 3:122,194,329...122,206,671
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B increases phosphorylation ISO 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of PPP1R1B protein CTD PMID:11880652 NCBI chr10:86,303,727...86,312,770
Ensembl chr10:86,303,727...86,312,762
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of PTGS2 mRNA
[Poly I-C results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine] which results in increased expression of PTGS2 mRNA; Poly I-C promotes the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of PTGS2 mRNA]
CTD PMID:24889602 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases phosphorylation
multiple interactions
EXP 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of RELA protein
gastrodin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of RELA protein]; rhyncophylline inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of RELA protein]; Tiapride Hydrochloride inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of RELA protein]
CTD PMID:30790395, PMID:31231976 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases phosphorylation
EXP rhyncophylline inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of STAT3 protein]; Tiapride Hydrochloride inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of STAT3 protein] CTD PMID:31231976 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tlr4 toll-like receptor 4 increases expression
multiple interactions
EXP 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of TLR4 protein
gastrodin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of TLR4 protein]; Tiapride Hydrochloride inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of TLR4 protein]
CTD PMID:30790395 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP 4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of and results in increased secretion of TNF protein; gastrodin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of TNF protein]; rhyncophylline inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of and results in increased secretion of TNF protein]; Tiapride Hydrochloride inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of and results in increased secretion of TNF protein]; Tiapride Hydrochloride inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of TNF protein] CTD PMID:30790395, PMID:31231976 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
3-bromo-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2,6-dimethoxybenzamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd2 dopamine receptor D2 multiple interactions
affects binding
EXP [[Remoxipride results in decreased activity of DRD2 protein] co-treated with [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide results in decreased activity of HTR1A protein]] results in increased susceptibility to Pilocarpine; [Remoxipride results in decreased activity of DRD2 protein] inhibits the reaction [Dopamine results in decreased susceptibility to Pilocarpine]; Remoxipride binds to and results in decreased activity of DRD2 protein; Remoxipride inhibits the reaction [N-n-propylnorapomorphine binds to DRD2 protein]; Remoxipride inhibits the reaction [Spiperone binds to DRD2 protein]
Remoxipride binds to DRD2 protein
CTD PMID:1724532, PMID:6149133, PMID:7901417, PMID:15140183 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions EXP [[Remoxipride results in decreased activity of DRD2 protein] co-treated with [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide results in decreased activity of HTR1A protein]] results in increased susceptibility to Pilocarpine CTD PMID:15140183 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
denopamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO denopamine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation
multiple interactions
ISO UGT2B7 protein results in increased glucuronidation of denopamine
Diclofenac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of denopamine]
CTD PMID:15608137 NCBI chr14:22,597,103...22,619,968 JBrowse link
flavokawain B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO flavokawain B results in decreased phosphorylation of AKT1 protein
TRIB3 protein affects the reaction [flavokawain B results in decreased phosphorylation of AKT1 protein]
CTD PMID:30025493 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression
ISO 4-phenylbutyric acid inhibits the reaction [flavokawain B results in increased expression of ATF4 protein]; ATF4 protein affects the reaction [flavokawain B results in increased expression of DDIT3 protein]; ATF4 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; ATF4 protein affects the reaction [flavokawain B results in increased expression of TRIB3 protein] CTD PMID:30025493 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atg5 autophagy related 5 multiple interactions
affects response to substance
ISO [ATG5 protein affects the susceptibility to flavokawain B] which affects the cleavage of CASP3 protein; [ATG5 protein affects the susceptibility to flavokawain B] which affects the cleavage of PARP1 protein; [ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of CDKN1A protein; [ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of GLB1 protein; [ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of MAP1LC3B protein modified form; [ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of MKI67 protein; ATG5 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form] CTD PMID:30025493 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Atg7 autophagy related 7 affects response to substance
multiple interactions
ISO ATG7 protein affects the susceptibility to flavokawain B
[ATG7 protein affects the susceptibility to flavokawain B] which affects the cleavage of CASP3 protein; [ATG7 protein affects the susceptibility to flavokawain B] which affects the cleavage of PARP1 protein; ATG7 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]
CTD PMID:30025493 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [ATG5 protein affects the susceptibility to flavokawain B] which affects the cleavage of CASP3 protein; [ATG7 protein affects the susceptibility to flavokawain B] which affects the cleavage of CASP3 protein CTD PMID:30025493 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of CDKN1A protein; [Chloroquine co-treated with flavokawain B] results in decreased expression of CDKN1A protein CTD PMID:30025493 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO 4-phenylbutyric acid inhibits the reaction [flavokawain B results in increased expression of DDIT3 protein]; ATF4 protein affects the reaction [flavokawain B results in increased expression of DDIT3 protein]; DDIT3 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form] CTD PMID:30025493 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation ISO flavokawain B results in increased phosphorylation of EIF2AK3 protein CTD PMID:30025493 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO flavokawain B results in increased phosphorylation of EIF2S1 protein CTD PMID:30025493 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Glb1 galactosidase, beta 1 multiple interactions
increases expression
ISO [ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of GLB1 protein; [Chloroquine co-treated with flavokawain B] results in decreased expression of GLB1 protein
flavokawain B results in increased expression of GLB1 protein
CTD PMID:30025493 NCBI chr 8:122,439,328...122,511,939
Ensembl chr 8:122,439,328...122,511,939
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO flavokawain B results in increased expression of HSPA5 protein CTD PMID:30025493 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression
ISO 3-methyladenine inhibits the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; 4-phenylbutyric acid inhibits the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; [ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of MAP1LC3B protein modified form; [Chloroquine co-treated with flavokawain B] results in increased expression of MAP1LC3B protein modified form; ATF4 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; ATG4 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; ATG5 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; ATG7 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; DDIT3 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form] CTD PMID:30025493 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO [ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of MKI67 protein; [Chloroquine co-treated with flavokawain B] results in decreased expression of MKI67 protein CTD PMID:30025493 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation
ISO TRIB3 protein affects the reaction [flavokawain B results in decreased phosphorylation of MTOR protein] CTD PMID:30025493 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [ATG5 protein affects the susceptibility to flavokawain B] which affects the cleavage of PARP1 protein; [ATG7 protein affects the susceptibility to flavokawain B] which affects the cleavage of PARP1 protein; [flavokawain B co-treated with 3-methyladenine] results in increased cleavage of PARP1 protein CTD PMID:30025493 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation
multiple interactions
ISO flavokawain B results in decreased phosphorylation of RPS6KB1 protein
TRIB3 protein affects the reaction [flavokawain B results in decreased phosphorylation of RPS6KB1 protein]
CTD PMID:30025493 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO flavokawain B results in increased expression of SQSTM1 protein CTD PMID:30025493 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Trib3 tribbles pseudokinase 3 multiple interactions
increases expression
ISO ATF4 protein affects the reaction [flavokawain B results in increased expression of TRIB3 protein]; TRIB3 protein affects the reaction [flavokawain B results in decreased phosphorylation of AKT1 protein]; TRIB3 protein affects the reaction [flavokawain B results in decreased phosphorylation of MTOR protein]; TRIB3 protein affects the reaction [flavokawain B results in decreased phosphorylation of RPS6KB1 protein] CTD PMID:30025493 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
JBrowse link
isomethyleugenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsta1 glutathione S-transferase alpha 1 decreases activity ISO isomethyleugenol results in decreased activity of GSTA1 protein CTD PMID:8620581 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 decreases activity EXP isomethyleugenol results in decreased activity of GSTA2 protein CTD PMID:8620581 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta3 glutathione S-transferase alpha 3 decreases activity EXP isomethyleugenol results in decreased activity of GSTA3 protein CTD PMID:8620581 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases activity ISO
EXP
isomethyleugenol results in decreased activity of GSTM1 protein CTD PMID:8620581 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases activity EXP isomethyleugenol results in decreased activity of GSTM2 protein CTD PMID:8620581 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity ISO
EXP
isomethyleugenol results in decreased activity of GSTP1 protein CTD PMID:8620581 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G LOC100912605 olfactory receptor 5D14-like multiple interactions ISO [isomethyleugenol binds to and results in decreased activity of OLFR73 protein] which results in decreased transport of Calcium; isomethyleugenol binds to and results in decreased activity of OLFR73 protein; isomethyleugenol binds to and results in increased activity of OLFR73 protein; isomethyleugenol inhibits the reaction [[Eugenol binds to OLFR73 protein] which results in increased transport of Calcium] CTD PMID:14685265, PMID:15716417, PMID:21142015 NCBI chr 3:76,255,179...76,256,129
Ensembl chr 3:76,255,179...76,256,129
JBrowse link
papaverine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor increases expression EXP Papaverine results in increased expression of BDNF mRNA CTD PMID:8601816 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
increases activity
ISO Papaverine promotes the reaction [CFTR protein affects the secretion of Chlorides]
Papaverine results in increased activity of CFTR protein
CTD PMID:12714375 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Cldn5 claudin 5 decreases expression EXP Papaverine results in decreased expression of CLDN5 protein CTD PMID:20728510 NCBI chr11:86,356,292...86,357,718
Ensembl chr11:86,356,294...86,357,718
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression EXP Papaverine results in increased expression of CREB1 mRNA CTD PMID:8601816 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Papaverine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:18493746 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO Papaverine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein] CTD PMID:18493746 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression ISO Papaverine results in decreased expression of HAMP mRNA CTD PMID:25633564 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Lipe lipase E, hormone sensitive type multiple interactions EXP Papaverine inhibits the reaction [Isoproterenol affects the localization of LIPE protein]; Papaverine inhibits the reaction [Isoproterenol results in increased activity of LIPE protein] CTD PMID:10894095 NCBI chr 1:82,248,031...82,266,727
Ensembl chr 1:82,248,046...82,266,727
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases activity ISO Papaverine results in increased activity of NR1H4 protein CTD PMID:22414727 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 increases expression EXP Papaverine results in increased expression of NTRK2 mRNA CTD PMID:8601816 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Ocln occludin decreases expression EXP Papaverine results in decreased expression of OCLN protein CTD PMID:20728510 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
JBrowse link
G Pde7a phosphodiesterase 7A multiple interactions ISO Papaverine inhibits the reaction [PDE7A protein results in increased hydrolysis of Cyclic AMP] CTD PMID:10618442 NCBI chr 2:104,042,124...104,134,101
Ensembl chr 2:104,045,811...104,134,101
JBrowse link
G Pde7b phosphodiesterase 7B multiple interactions ISO Papaverine inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP] CTD PMID:10618442 NCBI chr 1:15,889,845...16,203,909
Ensembl chr 1:15,893,533...16,203,909
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO
EXP
Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]
CTD PMID:9830022, PMID:12411423 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
PD-166866 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf1 fibroblast growth factor 1 multiple interactions EXP PD 166866 inhibits the reaction [FGF1 protein results in increased abundance of Nitric Oxide]; PD 166866 inhibits the reaction [FGF1 protein results in increased expression of and results in increased secretion of NGF protein]; PD 166866 inhibits the reaction [FGF1 protein results in increased expression of FGFR1 protein]; PD 166866 inhibits the reaction [FGF1 protein results in increased expression of NOS2 mRNA]; PD 166866 inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA] CTD PMID:15121739, PMID:15773903, PMID:16524372 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 decreases activity
multiple interactions
ISO
EXP
PD 166866 results in decreased activity of FGFR1 protein
PD 166866 inhibits the reaction [FGF1 protein results in increased expression of FGFR1 protein]; PD 166866 inhibits the reaction [FGFR1 protein results in increased phosphorylation of FGFR1 protein]
CTD PMID:12805413, PMID:15522930, PMID:15773903 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link
G Ngf nerve growth factor multiple interactions EXP PD 166866 inhibits the reaction [FGF1 protein results in increased expression of and results in increased secretion of NGF protein] CTD PMID:15773903 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP PD 166866 inhibits the reaction [FGF1 protein results in increased expression of NOS2 mRNA] CTD PMID:16524372 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Postn periostin multiple interactions EXP PD 166866 inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA] CTD PMID:15121739 NCBI chr 2:143,656,820...143,688,087
Ensembl chr 2:143,656,793...143,688,087
JBrowse link
PD173074 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO [arsenic trioxide results in increased susceptibility to PD 173074] which results in decreased expression of BIRC5 protein CTD PMID:27794399 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [PKI 166 co-treated with PD 173074] results in decreased expression of CCND1 protein CTD PMID:15377668 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions ISO PD 173074 inhibits the reaction [FGF1 protein results in increased phosphorylation of FGFR4 protein] CTD PMID:15709206 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Fgf16 fibroblast growth factor 16 multiple interactions ISO PD 173074 inhibits the reaction [FGF16 protein results in increased phosphorylation of MAPK1 protein]; PD 173074 inhibits the reaction [FGF16 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:24253043 NCBI chr  X:76,786,728...76,796,311
Ensembl chr  X:76,786,466...76,797,069
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 decreases activity
decreases expression
multiple interactions
ISO PD 173074 results in decreased activity of FGFR1 protein
PD 173074 results in decreased expression of FGFR1 protein
[PD 173074 results in decreased activity of FGFR1 protein] inhibits the reaction [[Crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein]; Arsenic Trioxide promotes the reaction [PD 173074 results in decreased expression of FGFR1 protein]; PD 173074 promotes the reaction [Arsenic Trioxide results in decreased expression of FGFR1 protein]
CTD PMID:22683780, PMID:27794399 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 decreases activity ISO PD 173074 results in decreased activity of FGFR3 protein CTD PMID:15029211 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706
JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 multiple interactions
decreases activity
ISO PD 173074 inhibits the reaction [FGF1 protein results in increased phosphorylation of FGFR4 protein]
PD 173074 results in decreased activity of FGFR4 protein
CTD PMID:15377668, PMID:15709206 NCBI chr17:9,990,072...10,004,339
Ensembl chr17:9,990,078...10,004,321
JBrowse link
G Hgf hepatocyte growth factor multiple interactions ISO [PD 173074 results in decreased activity of FGFR1 protein] inhibits the reaction [[crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] CTD PMID:22683780 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
decreases expression
multiple interactions
ISO PD 173074 results in decreased phosphorylation of MAPK1 protein
PD 173074 results in decreased expression of MAPK1 protein
PD 173074 inhibits the reaction [PHLPP1 gene mutant form results in increased phosphorylation of MAPK1 protein]
PD 173074 inhibits the reaction [FGF16 protein results in increased phosphorylation of MAPK1 protein]
CTD PMID:15029211, PMID:24253043, PMID:25953896, PMID:27794399 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
decreases expression
multiple interactions
ISO PD 173074 results in decreased phosphorylation of MAPK3 protein
PD 173074 results in decreased expression of MAPK3 protein
PD 173074 inhibits the reaction [FGF16 protein results in increased phosphorylation of MAPK3 protein]
PD 173074 inhibits the reaction [PHLPP1 gene mutant form results in increased phosphorylation of MAPK3 protein]
CTD PMID:15029211, PMID:24253043, PMID:25953896, PMID:27794399 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase multiple interactions ISO [PD 173074 results in decreased activity of FGFR1 protein] inhibits the reaction [[crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] CTD PMID:22683780 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [arsenic trioxide co-treated with PD 173074] results in increased expression of PARP1 protein modified form; [arsenic trioxide results in increased susceptibility to PD 173074] which results in increased expression of PARP1 protein modified form; [PD 173074 results in increased susceptibility to arsenic trioxide] which results in increased expression of PARP1 protein modified form CTD PMID:27794399 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 multiple interactions ISO PD 173074 inhibits the reaction [PHLPP1 gene mutant form results in increased phosphorylation of MAPK1 protein]; PD 173074 inhibits the reaction [PHLPP1 gene mutant form results in increased phosphorylation of MAPK3 protein] CTD PMID:25953896 NCBI chr13:26,145,989...26,394,505
Ensembl chr13:26,172,243...26,394,505
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases expression
multiple interactions
ISO PD 173074 results in decreased expression of RAF1 protein; PD 173074 results in decreased expression of RAF1 protein modified form
[arsenic trioxide co-treated with PD 173074] results in decreased expression of RAF1 protein; [arsenic trioxide co-treated with PD 173074] results in decreased expression of RAF1 protein modified form; [arsenic trioxide results in increased susceptibility to PD 173074] which results in decreased expression of RAF1 protein; [PD 173074 results in increased susceptibility to arsenic trioxide] which results in decreased expression of RAF1 protein; [PD 173074 results in increased susceptibility to arsenic trioxide] which results in decreased expression of RAF1 protein modified form; arsenic trioxide promotes the reaction [PD 173074 results in decreased expression of RAF1 protein modified form]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[arsenic trioxide co-treated with PD 173074] results in decreased expression of RAF1 protein modified form]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[arsenic trioxide co-treated with PD 173074] results in decreased expression of RAF1 protein]
CTD PMID:27794399 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO [PKI 166 co-treated with PD 173074] results in decreased activity of RPS6KB1 protein CTD PMID:15377668 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions
decreases expression
ISO [Arsenic Trioxide co-treated with PD 173074] results in decreased expression of SRC protein; [Arsenic Trioxide results in increased susceptibility to PD 173074] which results in decreased expression of SRC protein; [PD 173074 results in increased susceptibility to Arsenic Trioxide] which results in decreased expression of SRC protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Arsenic Trioxide co-treated with PD 173074] results in decreased expression of SRC protein]; PD 173074 promotes the reaction [Arsenic Trioxide results in decreased expression of SRC protein modified form]; PD 173074 promotes the reaction [Arsenic Trioxide results in decreased expression of SRC protein]
PD 173074 results in decreased expression of SRC protein; PD 173074 results in decreased expression of SRC protein modified form
CTD PMID:27794399 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Tbx3 T-box transcription factor 3 multiple interactions ISO PD 173074 inhibits the reaction [afimoxifene results in increased expression of TBX3 protein]; PD 173074 inhibits the reaction [Estrogens results in increased expression of TBX3 protein] CTD PMID:21098263 NCBI chr12:42,479,518...42,494,588
Ensembl chr12:42,480,560...42,492,526
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [PD 173074 inhibits the reaction [Sodium Chloride results in increased expression of VEGFA mRNA]]; PD 173074 inhibits the reaction [Sodium Chloride results in increased expression of VEGFA mRNA] CTD PMID:26800359 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
sinapic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G G6pd glucose-6-phosphate dehydrogenase decreases activity ISO sinapinic acid results in decreased activity of G6PD protein CTD PMID:25130191 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO sinapinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] CTD PMID:18841975 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Mb myoglobin multiple interactions EXP sinapinic acid inhibits the reaction [Isoproterenol results in increased expression of MB protein] CTD PMID:32627257 NCBI chr 7:118,101,633...118,108,864
Ensembl chr 7:118,101,634...118,108,864
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO sinapinic acid inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein] CTD PMID:18841975 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO sinapinic acid inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:18841975 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO sinapinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; sinapinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:18841975 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Ogdh oxoglutarate dehydrogenase multiple interactions EXP sinapinic acid inhibits the reaction [Isoproterenol results in decreased activity of OGDH protein] CTD PMID:32627257 NCBI chr14:86,414,924...86,481,903
Ensembl chr14:86,414,949...86,613,327
JBrowse link
G Pgd phosphogluconate dehydrogenase decreases activity ISO sinapinic acid results in decreased activity of PGD protein CTD PMID:25130191 NCBI chr 5:165,966,128...165,982,327 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO sinapinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; sinapinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:18841975 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO sinapinic acid inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:18841975 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO sinapinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:18841975 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
syringic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhfr dihydrofolate reductase decreases activity ISO syringic acid results in decreased activity of DHFR protein CTD PMID:25418905 NCBI chr 2:21,931,887...21,958,927
Ensembl chr 2:21,931,493...21,962,453
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO syringic acid inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of and results in decreased phosphorylation of GSK3B protein] CTD PMID:31586550 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Mpo myeloperoxidase decreases activity ISO syringic acid results in decreased activity of MPO protein CTD PMID:24060682 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
tranilast term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases response to substance
increases expression
multiple interactions
ISO AHR protein results in increased susceptibility to tranilast
tranilast results in increased expression of AHR mRNA
AHR protein promotes the reaction [tranilast results in increased expression of AHR mRNA]; AHR protein promotes the reaction [tranilast results in increased expression of CYP1A1 mRNA]; tranilast promotes the reaction [AHR protein binds to CYP1A1 promoter]
CTD PMID:25826687 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO tranilast results in decreased expression of CXCR4 mRNA CTD PMID:25826687 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO AHR protein promotes the reaction [tranilast results in increased expression of CYP1A1 mRNA]; tranilast promotes the reaction [AHR protein binds to CYP1A1 promoter] CTD PMID:25826687 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 affects expression ISO tranilast affects the expression of CYP1B1 mRNA CTD PMID:25826687 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO tranilast inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      atom 19782
        nonmetal atom 19657
          oxygen atom 19321
            oxygen molecular entity 19321
              organooxygen compound 18777
                ether 15937
                  aromatic ether 15393
                    methoxybenzenes 1831
                      dimethoxybenzene 96
                        (+)-(7''S,8S,8'R,8''R)-4,4''-dihydroxy-3,3',3'',5'-tetramethoxy-4',8''-oxy-8,8'-sesquineolignan-7''-ol 0
                        (+)-(7R,7'R,7''R,7'''R,8S,8'S,8''S,8'''S)-4'',4'''-dihydroxy-3,3',3'',3''',5,5'-hexamethoxy-7,9':7',9-diepoxy-4,8'':4',8'''-bisoxy-8,8'-dineolignan-7'',7''',9'',9'''-tetraol 0
                        (+)-(7R,7'R,7''R,7'''S,8S,8'S,8''S,8'''S)-4'',4'''-dihydroxy-3,3',3'',3''',5,5'-hexamethoxy-7,9':7',9-diepoxy-4,8'':4',8'''-bisoxy-8,8'-dineolignan-7'',7''',9'',9'''-tetraol 0
                        (+)-(7R,7'R,7''S,7'''S,8S,8'S,8''S,8'''S)-4'',4'''-dihydroxy-3,3',3'',3''',5,5'-hexamethoxy-7,9':7',9-diepoxy-4,8'':4',8'''-bisoxy-8,8'-dineolignan-7'',7''',9'',9'''-tetraol 0
                        (+)-(7S,8R,8'R)-5,5'-dimethoxylariciresinol 0
                        (+)-(7S,8S)-1',4-dihydroxy-3,3',5'-trimethoxy-7',8',9'-trinor-8,4'-oxyneolignan-7,9-diol 0
                        (+)-(7S,8S)-4-hydroxy-3,3',5'-trimethoxy-8',9'-dinor-8,4'-oxyneolignan-7,9-diol-7'-oic acid 0
                        (+)-(8S,8'R)-4,4'-dihydroxy-3,3',5'-trimethoxylignan 0
                        (+)-(8S,8'R)-9'-acetoxy-4,4'-dihydroxy-3,3',5'-trimethoxylignan 0
                        (+)-(8S,8'R)-9-acetoxy-4,4'-dihydroxy-3,3',5'-trimethoxylignan 0
                        (+)-5'-methoxylariciresinol 0
                        (+)-lyoniresinol + 0
                        (+)-lyoniresinol 4,4'-bis-O-beta-D-glucopyranoside 0
                        (+)-lyoniresinol-3-alpha-O-beta-D-glucopyranoside 0
                        (-)-(7''R,8''S)-4'',5,7-trihydroxy-3',3'',5'-trimethoxy-4',8''-oxyflavonolignan-7'',9''-diol 0
                        (-)-(7''R,8''S)-4'',5,7-trihydroxy-3',5'-dimethoxy-4',8''-oxyflavonolignan-7'',9''-diol 0
                        (-)-(7''S,8''S)-4'',5,7-trihydroxy-3',3'',5'-trimethoxy-4',8''-oxyflavonolignan-7'',9''-diol 0
                        (-)-(7''S,8''S)-4'',5,7-trihydroxy-3',5'-dimethoxy-4',8''-oxyflavonolignan-7'',9''-diol 0
                        (-)-(7'S,8S,8'R)-4,4'-dihydroxy-3,3',5,5'-tetramethoxy-7',9-epoxylignan-9'-ol-7-one 0
                        (-)-(7R,7'R,7''R,8S,8'S,8''S)-4',4''-dihydroxy-3,3',3'',5,5',5''-hexamethoxy-7,9':7',9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol 0
                        (-)-(7R,7'R,7''R,8S,8'S,8''S)-4',4''-dihydroxy-3,3',3'',5,5'-pentamethoxy-7,9':7',9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol 0
                        (-)-(7R,7'R,7''R,8S,8'S,8''S)-4',4''-dihydroxy-3,3',3'',5-tetramethoxy-7,9':7',9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol 0
                        (-)-(7R,7'R,7''S,8S,8'S,8''S)-4',4''-dihydroxy-3,3',3'',5,5',5''-hexamethoxy-7,9':7',9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol 0
                        (-)-(7R,7'R,7''S,8S,8'S,8''S)-4',4''-dihydroxy-3,3',3'',5,5'-pentamethoxy-7,9':7',9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol 0
                        (-)-(7R,7'R,7''S,8S,8'S,8''S)-4',4''-dihydroxy-3,3',3'',5-tetramethoxy-7,9':7',9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol 0
                        (-)-(7R,8R,8'R)-4,4'-dihydroxy-3,3',5'-trimethoxy-7,9'-epoxylignan 0
                        (-)-5'-desmethylyatein 0
                        (-)-5'-methoxyisolariciresinol 0
                        (-)-medioresinol 0
                        (2,3-dimethoxyphenyl)-(1-pyrrolidinyl)methanethione 0
                        (3,4-dimethoxyphenyl)methanol + 0
                        (3,5-dimethoxyphenyl)-(4-methylsulfonyl-1-piperazinyl)methanone 0
                        (E)-sinapaldehyde + 0
                        (E)-sinapaldehyde 4-O-beta-D-glucopyranoside 0
                        1-(1,3-benzoxazol-2-yl)-N-[(2,5-dimethoxyphenyl)methyl]-3-piperidinecarboxamide 0
                        1-(2,1,3-benzothiadiazol-4-yl)-3-[(3,4-dimethoxyphenyl)methylideneamino]urea 0
                        1-(2,1,3-benzothiadiazol-4-ylsulfonyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-4-piperidinecarboxamide 0
                        1-(2,5-dimethoxyphenyl)-3-(3-pyridinyl)-2-propen-1-one 0
                        1-(2-fluoro-3,4-dimethoxyphenyl)-2-(propan-2-ylamino)ethanol 0
                        1-(3,4-dimethoxyphenyl)-1-cyclohexanecarboxamide 0
                        1-(3,4-dimethoxyphenyl)-3-[[2-(4-ethoxyphenyl)-1-oxoethyl]amino]thiourea 0
                        1-(3,4-dimethoxyphenyl)-N-[3-(ethylthio)-1,2,4-triazol-4-yl]methanimine 0
                        1-(3,4-dimethoxyphenyl)-N-propan-2-yl-1-cyclopentanecarboxamide 0
                        1-(3,4-dimethoxyphenyl)ethanol 0
                        1-(3-fluoro-4,5-dimethoxyphenyl)-2-(propan-2-ylamino)ethanol 0
                        1-(4-\{[1,3-dihydroxy-1-(4-hydroxy-3-methoxyphenyl)propan-2-yl]oxy\}-3,5-dimethoxyphenyl)propane-1,2,3-triol 0
                        1-(4-hydroxy-3,5-dimethoxyphenyl)ethanol 0
                        1-O-3,4-dimethoxy-5-hydroxyphenyl-(6-O-3,5-dimethoxygalloyl)-beta-D-glucopyranoside 0
                        1-O-3,4-dimethoxy-5-hydroxyphenyl-(6-O-vanilloyl)-beta-D-glucopyranoside 0
                        1-O-sinapoyl-beta-D-glucose 0
                        1-[(3,4-dimethoxyphenyl)-[1-(2-methoxyethyl)-5-tetrazolyl]methyl]-2,3-dihydroindole 0
                        1-[(3,4-dimethoxyphenyl)methyl]-4-(4-hydroxyphenyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester 0
                        1-[2-(3,4-dimethoxyphenyl)-1-oxoethyl]-4-piperidinecarboxylic acid methyl ester 0
                        1-[2-(3,4-dimethoxyphenyl)ethyl]-6-propyl-2-sulfanylidene-7,8-dihydro-5H-pyrimido[4,5-d]pyrimidin-4-one 0
                        1-[4-(3,5-dimethoxyphenyl)-2-thiazolyl]-4-piperidinecarboxamide 0
                        1-[[(2R,3S)-8-[2-(3,4-dimethoxyphenyl)ethynyl]-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-3,4-dihydro-2H-pyrido[2,3-b][1,5]oxazocin-2-yl]methyl]-3-(3,5-dimethyl-4-isoxazolyl)-1-methylurea 0
                        1-cyclohexyl-3-[1-(3,4-dimethoxyphenyl)ethyl]thiourea 0
                        1-cyclohexyl-5-[1-(2,4-dimethoxyanilino)ethylidene]-1,3-diazinane-2,4,6-trione 0
                        2',6'-dimethoxy-4'-hydroxyacetophenone 0
                        2'-O-methylodoratol 0
                        2,3-diacetoxypropioveratrone 0
                        2,4-dimethoxy-N-(5-nitro-2-pyridinyl)benzamide 0
                        2,5-bis[(3,4-dimethoxyphenyl)methylidene]-1-cyclopentanone 0
                        2,6-dimethoxyphenol + 0
                        2,6-dimethoxyphenol acetate 0
                        2-(1H-benzimidazol-2-yl)-4-(3,4-dimethoxyphenyl)-3-oxobutanenitrile 0
                        2-(2,3-dimethoxyphenyl)-3-(4-methoxyphenyl)-4-thiazolidinone 0
                        2-(2,4-dimethoxyphenyl)acetic acid 0
                        2-(2,5-dimethoxyphenyl)-5-(5-methyl-2-furanyl)-1,3,4-oxadiazole 0
                        2-(2,5-dimethoxyphenyl)ethanamine 0
                        2-(3,4-dimethoxyphenyl)-1-[5-hydroxy-3-methyl-5-(trifluoromethyl)-4H-pyrazol-1-yl]ethanone 0
                        2-(3,4-dimethoxyphenyl)-8-methoxy-4,4-dimethyl-5H-isothiazolo[5,4-c]quinoline-1-thione 0
                        2-(3,4-dimethoxyphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methylethanamine 0
                        2-(3,4-dimethoxyphenyl)-N-[3-(3-nitrophenyl)prop-2-enylideneamino]acetamide 0
                        2-(4-bromophenyl)-N-[(2-chloro-3,4-dimethoxyphenyl)methyl]-1-cyclopropanamine 0
                        2-(4-hydroxy-3,5-dimethoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-7H-pyrano[2,3-g][1,4]benzodioxin-7-one 0
                        2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine 28
                        2-Chloro-1-[5-(3,4-dimethoxyphenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-one 0
                        2-[(2,4-dimethoxyphenyl)methylidene]-6-methylthiazolo[3,2-b][1,2,4]triazine-3,7-dione 0
                        2-[(2,4-dimethoxyphenyl)methylideneamino]-1-nitroguanidine 0
                        2-[(2,5-dimethoxyanilino)methylidene]-1-cyclohexanone 0
                        2-[(4-bromophenoxy)methyl]-5-[2-(3,4-dimethoxyphenyl)ethylamino]-4-oxazolecarbonitrile 0
                        2-[2-(2,3-dimethoxyphenyl)-4-thiazolyl]acetic acid 0
                        2-[4-(heptylthio)-2,5-dimethoxyphenyl]-N-methylethanamine 0
                        2-[[(2,3-dimethoxyphenyl)-oxomethyl]amino]-5-propan-2-yl-3-thiophenecarboxamide 0
                        2-[[(3,4-dimethoxyphenyl)-oxomethyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide 0
                        2-[[(3,4-dimethoxyphenyl)-oxomethyl]amino]-N-(2-furanylmethyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide 0
                        2-[[2-(3,4-dimethoxyanilino)-2-oxoethyl]thio]-3-pyridinecarboxylic acid propan-2-yl ester 0
                        2-[[3-[2-(3,4-dimethoxyphenyl)ethyl]-4-oxo-2-thieno[3,2-d]pyrimidinyl]thio]-N-(5-methyl-3-isoxazolyl)acetamide 0
                        2-[[5-cyano-2-(3,4-dimethoxyphenyl)-4-oxo-2,3-dihydro-1,3-thiazin-6-yl]thio]acetic acid ethyl ester 0
                        2-amino-1-(3,4-dimethoxyphenyl)ethanol 0
                        2-fluoro-N-(1-hydroxy-2-methylpropan-2-yl)-4,5-dimethoxybenzamide 0
                        2-furancarboxylic acid [[amino-(3,4-dimethoxyphenyl)methylidene]amino] ester 0
                        3',6'-dihydroxy-2',4,4'-trimethoxy-chalcone 0
                        3,3''-dihydroxyterphenyllin 0
                        3,4-dimethoxy cinnamaldehyde 0
                        3,4-dimethoxy-N-(2-methyl-1,3-benzothiazol-6-yl)benzamide 0
                        3,4-dimethoxy-N-(3-methyl-1,3-benzothiazol-2-ylidene)benzamide 0
                        3,4-dimethoxy-N-[[2-(4-morpholinyl)-4-phenyl-5-thiazolyl]methylideneamino]benzamide 0
                        3,4-dimethoxy-N-[[[oxo(2-pyrazinyl)methyl]hydrazo]-sulfanylidenemethyl]benzamide 0
                        3,4-dimethoxybenzenecarbothioic acid S-(4-chlorophenyl) ester 0
                        3,4-dimethoxybenzyl acetate 0
                        3,4-dimethoxycinnamyl acetate 0
                        3,4-dimethoxycinnamyl alcohol 0
                        3,5-dimethoxy-N-(1H-1,2,4-triazol-5-yl)benzamide 0
                        3,5-dimethoxy-N-[(2-phenylethylamino)-sulfanylidenemethyl]benzamide 0
                        3,5-dimethoxy-N-[2-(4-morpholinyl)ethyl]benzamide 0
                        3-(2,4-dimethoxyphenyl)-6-phenyl-2-sulfanylidene-1H-thieno[2,3-d]pyrimidin-4-one 0
                        3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-[4-(diethylamino)butylamino]-1-methyl-4H-pyrimido[4,5-d]pyrimidin-2-one 0
                        3-(3,4,5-trimethoxyphenyl)propanoic acid [2-(3,5-dimethoxyanilino)-2-oxoethyl] ester 0
                        3-(3,4-dimethoxyphenyl)-2-(3-pyridinyl)-2-propenenitrile 0
                        3-(3,4-dimethoxyphenyl)propanoic acid 0
                        3-(4-chlorophenyl)-2-(2,3-dimethoxyphenyl)-4-thiazolidinone 0
                        3-[7-(2,4-dimethoxyphenyl)-1,4-thiazepan-5-ylidene]-6-methylpyran-2,4-dione 0
                        3-bromo-N-[(2,4-dimethoxyphenyl)methylideneamino]benzamide 0
                        3-bromo-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2,6-dimethoxybenzamide 2
                        3-heptadecylveratrole 0
                        3-hydroxyterphenyllin + 0
                        4''-dehydro-3-hydroxyterphenyllin 0
                        4''-deoxyterphenyllin 0
                        4-(2,4-dimethoxyphenyl)-3-methyl-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one 0
                        4-(3,4-dimethoxyphenyl)-1-(2-methoxyethyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester 0
                        4-(3,4-dimethoxyphenyl)-2-thiophen-2-ylthiazole 0
                        4-(3,4-dimethoxyphenyl)-N-(3-methyl-2-pyridinyl)-2-thiazolamine 0
                        4-O-beta-D-glucosyl-trans-sinapic acid 0
                        4-[2-(2,3-dimethoxyphenyl)ethenyl]pyridine 0
                        4-[2-(2,4-dimethoxyanilino)-2-oxoethyl]-5-thieno[3,2-b]pyrrolecarboxylic acid ethyl ester 0
                        4-[2-(allyloxy)vinyl]-1,2-dimethoxybenzene 0
                        4-acetoxy-3,5-dimethoxy-trans-cinnamaldehyde 0
                        4-allyl-2,6-dimethoxyphenol 0
                        4-amino-N'-[(3,4-dimethoxyphenyl)methylideneamino]-1,2,5-oxadiazole-3-carboximidamide 0
                        4-chloro-N-(4-chloro-2,5-dimethoxyphenyl)-5-dithiazolimine 0
                        4-hydroxy-5-propionyl-1,3-di-O-methylpyrogallol 0
                        4-morpholinecarboxylic acid [4-(2-amino-3-cyano-5-oxo-4,6,7,8-tetrahydro-1-benzopyran-4-yl)-2,6-dimethoxyphenyl] ester 0
                        5''-methoxyhydnocarpin-D 0
                        5-(2,4-dimethoxyphenyl)-7-(3,4-dimethoxyphenyl)-1,7-dihydrotetrazolo[1,5-a]pyrimidine 0
                        5-(3,4-dimethoxyphenyl)-2-(4-methylphenyl)-4-thieno[2,3-d][1,3]oxazinone 0
                        5-(3,4-dimethoxyphenyl)-2-methyl-4-(4-methyl-1-piperidinyl)thieno[2,3-d]pyrimidine 0
                        5-(3,4-dimethoxyphenyl)-2-methylsulfonyl-3-thiophen-2-yl-3,4-dihydropyrazole 0
                        5-(3,4-dimethoxyphenyl)-2-phenyl-4-thieno[2,3-d][1,3]oxazinone 0
                        5-(3,4-dimethoxyphenyl)-N-(3-pyridinyl)-3-isoxazolecarboxamide 0
                        5-(3,4-dimethoxyphenyl)-N-[1-[(2-methylphenyl)methyl]-4-pyrazolyl]-3-isoxazolecarboxamide 0
                        5-[(3,4-dimethoxyphenyl)-[4-(2-hydroxyethyl)-1-piperazinyl]methyl]-2-methyl-6-thiazolo[3,2-b][1,2,4]triazolol 0
                        5-[(3,4-dimethoxyphenyl)methyl]-1-prop-2-enyl-1,3-diazinane-2,4,6-trione 0
                        5-[(3,4-dimethoxyphenyl)methylidene]-3-(phenylmethyl)-2-(phenylmethyl)imino-4-thiazolidinone 0
                        5-[(4,5-dimethoxy-2-methylphenyl)methyl]pyrimidine-2,4-diamine 0
                        5-[1-[(3,5-dimethoxyphenyl)methylamino]ethylidene]-1-prop-2-enyl-1,3-diazinane-2,4,6-trione 0
                        5-[1-[(3,5-dimethoxyphenyl)methylamino]propylidene]-1-prop-2-enyl-1,3-diazinane-2,4,6-trione 0
                        5-[2-(3,4-dimethoxyphenyl)ethylamino]-2-[(2-fluorophenoxy)methyl]-4-oxazolecarbonitrile 0
                        5-[2-[(3,4-dimethoxyphenyl)methylidene]hydrazinyl]-6-methyl-2H-1,2,4-triazin-3-one 0
                        5-amino-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-4-triazolecarboxamide 0
                        5-amino-1-[(4-chlorophenyl)methyl]-4-[4-(3,4-dimethoxyphenyl)-2-thiazolyl]-2H-pyrrol-3-one 0
                        6-(chloromethyl)-N2-(2,5-dimethoxyphenyl)-1,3,5-triazine-2,4-diamine 0
                        6-[(3,4-dimethoxyphenyl)methyl]-3-[(2-hydroxy-4-oxo-1-cyclohexa-2,5-dienylidene)methylhydrazo]-2H-1,2,4-triazin-5-one 0
                        6-[3-(3,4-dimethoxyphenyl)-1H-pyrazolo[1,5-a]pyrimidin-5-ylidene]-1-cyclohexa-2,4-dienone 0
                        6-amino-1-[2-(3,4-dimethoxyphenyl)ethyl]-2-sulfanylidene-4-pyrimidinone 0
                        6-amino-4-(2,4-dimethoxyphenyl)-3-propyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile 0
                        6-amino-5-cyano-4-(2,4-dimethoxyphenyl)-2-(2-ethoxy-2-oxoethyl)-4H-pyran-3-carboxylic acid ethyl ester 0
                        6-chloro-N4-[(3,4-dimethoxyphenyl)methylideneamino]pyrimidine-4,5-diamine 0
                        7-(2,3-dimethoxyphenyl)-5-(trifluoromethyl)-1,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylic acid ethyl ester 0
                        7-(2,5-dimethoxyphenyl)-5-(trifluoromethyl)-1,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylic acid ethyl ester 0
                        D617 0
                        HG-9-91-01 0
                        LSM-32019 0
                        Methoxamine hydrochloride 0
                        N-(1,3-benzothiazol-2-yl)-2-[(3,4-dimethoxyphenyl)methylideneamino]oxyacetamide 0
                        N-(1H-indazol-6-yl)-2,4-dimethoxybenzamide 0
                        N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-2-(2,3-dimethoxyphenyl)acetamide 0
                        N-(2,4-dimethoxyphenyl)-N'-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]butanediamide 0
                        N-(2,5-dimethoxyphenyl)-4-(2,4-dimethyl-5-thiazolyl)-2-thiazolamine 0
                        N-(2-carbamoylphenyl)-2-(2,5-dimethoxyphenyl)quinoline-4-carboxamide 0
                        N-(3,4-dimethoxyphenyl)-2-[(4-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-2-yl)thio]acetamide 0
                        N-(3,4-dimethoxyphenyl)-3-(3-methoxyphenyl)-4,5-dihydroisoxazole-5-carboxamide 0
                        N-(3,4-dimethoxyphenyl)-6-phenyl-4-thieno[2,3-d]pyrimidinamine 0
                        N-[(2,5-dimethoxyphenyl)methylideneamino]-1-methyl-6-oxo-3-pyridinecarboxamide 0
                        N-[(2,5-dimethoxyphenyl)methylideneamino]-5-[(4-nitro-1-pyrazolyl)methyl]-2-furancarboxamide 0
                        N-[(3,4-dimethoxyphenyl)methyl]-3-(2-pyrimidinylthio)-1-propanamine 0
                        N-[(3,4-dimethoxyphenyl)methyl]-N-methyl-2-(2-pyridinyl)ethanamine 0
                        N-[(3,5-dimethoxyphenyl)methyl]-1-(2,3,4-trimethoxyphenyl)methanamine 0
                        N-[(3,5-dimethoxyphenyl)methyl]-1-[4-(methylthio)phenyl]methanamine 0
                        N-[1-(1H-benzimidazol-2-yl)-2-thiophen-2-ylethenyl]-3,4-dimethoxybenzamide 0
                        N-[1-[(4-chlorophenyl)methyl]-5-methyl-3-pyrazolyl]-5-(2,5-dimethoxyphenyl)-3-isoxazolecarboxamide 0
                        N-[1-[(4-chlorophenyl)methyl]-5-methyl-3-pyrazolyl]-5-(3,4-dimethoxyphenyl)-3-isoxazolecarboxamide 0
                        N-[2-(3,4-dimethoxyphenyl)ethyl]-2-[(4-methylphenyl)thio]propanamide 0
                        N-[2-(3,4-dimethoxyphenyl)ethyl]-2-[3-(4-fluorophenyl)-2,4-dioxo-1-thieno[3,2-d]pyrimidinyl]acetamide 0
                        N-[2-(3,4-dimethoxyphenyl)ethyl]-2-[[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]thio]acetamide 0
                        N-[2-(3,4-dimethoxyphenyl)ethyl]-4-(2,4-dimethyl-5-thiazolyl)-2-thiazolamine 0
                        N-[2-(3,4-dimethoxyphenyl)ethyl]-4-[[[3,4-dioxo-2-(1-pyrrolidinyl)-1-cyclobutenyl]amino]methyl]-1-cyclohexanecarboxamide 0
                        N-[2-(3,4-dimethoxyphenyl)ethyl]-5-thiophen-2-yl-3-isoxazolecarboxamide 0
                        N-[2-[2-[(3,4-dimethoxyphenyl)methylidene]hydrazinyl]-4-(4-methylphenyl)-5-thiazolyl]acetamide 0
                        N-[3-(4-\{[1-(5-chloro-2,4-dimethoxyanilino)-1-oxopropan-2-yl]sulfanyl\}anilino)-3-oxo-1-phenylprop-1-en-2-yl]benzamide 0
                        N-[4-(2,5-dimethoxyphenyl)-2-thiazolyl]-2-[(4-nitrophenyl)thio]acetamide 0
                        N-[4-(2,5-dimethoxyphenyl)-2-thiazolyl]-N-(2-oxolanylmethyl)cyclohexanecarboxamide 0
                        N-[5-(2,4-dimethoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-phenylacetamide 0
                        N-[5-(3,4-dimethoxyphenyl)-1,3,4-thiadiazol-2-yl]carbamic acid ethyl ester 0
                        N-[5-[(3,4-dimethoxyphenyl)methyl]-1,3,4-thiadiazol-2-yl]-4-methoxybenzamide 0
                        N-[5-[2-(2,5-dimethoxyanilino)-4-thiazolyl]-4-methyl-2-thiazolyl]-2-methylpentanamide 0
                        N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-5-iodo-2,3-dimethoxybenzamide 0
                        N-tert-butyl-2-[[5-(3,5-dimethoxyphenyl)-1,3,4-oxadiazol-2-yl]thio]-N-(phenylmethyl)acetamide 0
                        N2-[(3,4-dimethoxyphenyl)methylideneamino]-N4-phenyl-6-(1-piperidinyl)-1,3,5-triazine-2,4-diamine 0
                        N3,N6-bis(2,5-dimethoxyphenyl)pyridazine-3,6-diamine 0
                        N4-(2,5-dimethoxyphenyl)-N2-(3-methylbutyl)-5-nitropyrimidine-2,4,6-triamine 0
                        PD-166866 + 21
                        PD173074 18
                        [4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-(2,6-dimethoxyphenyl)methanone 0
                        [5-(2,5-dimethoxyphenyl)-3-isoxazolyl]-(4-morpholinyl)methanone 0
                        acetosyringone + 0
                        acetosyringone acetate 0
                        acetoveratrone 0
                        acuminatin 0
                        belladine 0
                        beta-hibitakanine 0
                        bihapten 1 dimethyl ether 0
                        brugunin A 0
                        buddlenol A 0
                        buddlenol B 0
                        buddlenol C 0
                        chloroneb 0
                        cryogenine 0
                        danielone 0
                        decimemide 0
                        demethoxyaschantin 0
                        denopamine 2
                        ficusequilignan A 0
                        flavokawain B 18
                        futokadsurin B 0
                        futokadsurin C 0
                        galgravin 0
                        griffithane A 0
                        griffithane B 0
                        griffithane C 0
                        homoveratric acid 0
                        isomethyleugenol + 6
                        kadsurenin C 0
                        kadsurenin L 0
                        kadsurenin M 0
                        lignin cw compound-147 0
                        manassantin A 0
                        manassantin B 0
                        methyl syringate 0
                        methyl-3,4-dimethoxycinnamate 0
                        papaverine 14
                        prenylterphenyllin 0
                        prenylterphenyllin A 0
                        prenylterphenyllin B 0
                        prenylterphenyllin C 0
                        rel-(+)-(7'S,8S,8'S)-4,4'-dihydroxy-3',5,5'-trimethoxy-2,7'-cyclolignan 0
                        rel-(-)-(7S,7'R,8S,8'R)-4,4'-dihydroxy-3,3',5'-trimethoxy-7,7'-epoxylignan 0
                        simulanol 0
                        sinapic acid + 11
                        sinapyl alcohol + 0
                        syringaldehyde + 0
                        syringaldehyde acetate 0
                        syringic acid + 3
                        syringic acid acetate 0
                        syringin 0
                        syringyl alcohol + 0
                        syringyl alcohol diacetate 0
                        syringylglycerol beta-guaiacyl ether 0
                        syringylresinol diacetate 0
                        terphenyllin + 0
                        terprenin 0
                        tetroxoprim 0
                        tranilast 5
                        trans-sinapyl actetate 0
                        vaccihein A 0
                        veratraldehyde 0
                        veratrole + 0
                        veratrone + 0
                        veratrone acetate 0
                        veratryl alcohol methyl ether 0
                        veratryl glycerol + 0
                        veratrylglycerol beta-guaiacyl ether 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                carbocyclic compound 18181
                                  benzenoid aromatic compound 17178
                                    benzenes 16920
                                      methoxybenzenes 1831
                                        dimethoxybenzene 96
                                          (+)-(7''S,8S,8'R,8''R)-4,4''-dihydroxy-3,3',3'',5'-tetramethoxy-4',8''-oxy-8,8'-sesquineolignan-7''-ol 0
                                          (+)-(7R,7'R,7''R,7'''R,8S,8'S,8''S,8'''S)-4'',4'''-dihydroxy-3,3',3'',3''',5,5'-hexamethoxy-7,9':7',9-diepoxy-4,8'':4',8'''-bisoxy-8,8'-dineolignan-7'',7''',9'',9'''-tetraol 0
                                          (+)-(7R,7'R,7''R,7'''S,8S,8'S,8''S,8'''S)-4'',4'''-dihydroxy-3,3',3'',3''',5,5'-hexamethoxy-7,9':7',9-diepoxy-4,8'':4',8'''-bisoxy-8,8'-dineolignan-7'',7''',9'',9'''-tetraol 0
                                          (+)-(7R,7'R,7''S,7'''S,8S,8'S,8''S,8'''S)-4'',4'''-dihydroxy-3,3',3'',3''',5,5'-hexamethoxy-7,9':7',9-diepoxy-4,8'':4',8'''-bisoxy-8,8'-dineolignan-7'',7''',9'',9'''-tetraol 0
                                          (+)-(7S,8R,8'R)-5,5'-dimethoxylariciresinol 0
                                          (+)-(7S,8S)-1',4-dihydroxy-3,3',5'-trimethoxy-7',8',9'-trinor-8,4'-oxyneolignan-7,9-diol 0
                                          (+)-(7S,8S)-4-hydroxy-3,3',5'-trimethoxy-8',9'-dinor-8,4'-oxyneolignan-7,9-diol-7'-oic acid 0
                                          (+)-(8S,8'R)-4,4'-dihydroxy-3,3',5'-trimethoxylignan 0
                                          (+)-(8S,8'R)-9'-acetoxy-4,4'-dihydroxy-3,3',5'-trimethoxylignan 0
                                          (+)-(8S,8'R)-9-acetoxy-4,4'-dihydroxy-3,3',5'-trimethoxylignan 0
                                          (+)-5'-methoxylariciresinol 0
                                          (+)-lyoniresinol + 0
                                          (+)-lyoniresinol 4,4'-bis-O-beta-D-glucopyranoside 0
                                          (+)-lyoniresinol-3-alpha-O-beta-D-glucopyranoside 0
                                          (-)-(7''R,8''S)-4'',5,7-trihydroxy-3',3'',5'-trimethoxy-4',8''-oxyflavonolignan-7'',9''-diol 0
                                          (-)-(7''R,8''S)-4'',5,7-trihydroxy-3',5'-dimethoxy-4',8''-oxyflavonolignan-7'',9''-diol 0
                                          (-)-(7''S,8''S)-4'',5,7-trihydroxy-3',3'',5'-trimethoxy-4',8''-oxyflavonolignan-7'',9''-diol 0
                                          (-)-(7''S,8''S)-4'',5,7-trihydroxy-3',5'-dimethoxy-4',8''-oxyflavonolignan-7'',9''-diol 0
                                          (-)-(7'S,8S,8'R)-4,4'-dihydroxy-3,3',5,5'-tetramethoxy-7',9-epoxylignan-9'-ol-7-one 0
                                          (-)-(7R,7'R,7''R,8S,8'S,8''S)-4',4''-dihydroxy-3,3',3'',5,5',5''-hexamethoxy-7,9':7',9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol 0
                                          (-)-(7R,7'R,7''R,8S,8'S,8''S)-4',4''-dihydroxy-3,3',3'',5,5'-pentamethoxy-7,9':7',9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol 0
                                          (-)-(7R,7'R,7''R,8S,8'S,8''S)-4',4''-dihydroxy-3,3',3'',5-tetramethoxy-7,9':7',9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol 0
                                          (-)-(7R,7'R,7''S,8S,8'S,8''S)-4',4''-dihydroxy-3,3',3'',5,5',5''-hexamethoxy-7,9':7',9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol 0
                                          (-)-(7R,7'R,7''S,8S,8'S,8''S)-4',4''-dihydroxy-3,3',3'',5,5'-pentamethoxy-7,9':7',9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol 0
                                          (-)-(7R,7'R,7''S,8S,8'S,8''S)-4',4''-dihydroxy-3,3',3'',5-tetramethoxy-7,9':7',9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol 0
                                          (-)-(7R,8R,8'R)-4,4'-dihydroxy-3,3',5'-trimethoxy-7,9'-epoxylignan 0
                                          (-)-5'-desmethylyatein 0
                                          (-)-5'-methoxyisolariciresinol 0
                                          (-)-medioresinol 0
                                          (2,3-dimethoxyphenyl)-(1-pyrrolidinyl)methanethione 0
                                          (3,4-dimethoxyphenyl)methanol + 0
                                          (3,5-dimethoxyphenyl)-(4-methylsulfonyl-1-piperazinyl)methanone 0
                                          (E)-sinapaldehyde + 0
                                          (E)-sinapaldehyde 4-O-beta-D-glucopyranoside 0
                                          1-(1,3-benzoxazol-2-yl)-N-[(2,5-dimethoxyphenyl)methyl]-3-piperidinecarboxamide 0
                                          1-(2,1,3-benzothiadiazol-4-yl)-3-[(3,4-dimethoxyphenyl)methylideneamino]urea 0
                                          1-(2,1,3-benzothiadiazol-4-ylsulfonyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-4-piperidinecarboxamide 0
                                          1-(2,5-dimethoxyphenyl)-3-(3-pyridinyl)-2-propen-1-one 0
                                          1-(2-fluoro-3,4-dimethoxyphenyl)-2-(propan-2-ylamino)ethanol 0
                                          1-(3,4-dimethoxyphenyl)-1-cyclohexanecarboxamide 0
                                          1-(3,4-dimethoxyphenyl)-3-[[2-(4-ethoxyphenyl)-1-oxoethyl]amino]thiourea 0
                                          1-(3,4-dimethoxyphenyl)-N-[3-(ethylthio)-1,2,4-triazol-4-yl]methanimine 0
                                          1-(3,4-dimethoxyphenyl)-N-propan-2-yl-1-cyclopentanecarboxamide 0
                                          1-(3,4-dimethoxyphenyl)ethanol 0
                                          1-(3-fluoro-4,5-dimethoxyphenyl)-2-(propan-2-ylamino)ethanol 0
                                          1-(4-\{[1,3-dihydroxy-1-(4-hydroxy-3-methoxyphenyl)propan-2-yl]oxy\}-3,5-dimethoxyphenyl)propane-1,2,3-triol 0
                                          1-(4-hydroxy-3,5-dimethoxyphenyl)ethanol 0
                                          1-O-3,4-dimethoxy-5-hydroxyphenyl-(6-O-3,5-dimethoxygalloyl)-beta-D-glucopyranoside 0
                                          1-O-3,4-dimethoxy-5-hydroxyphenyl-(6-O-vanilloyl)-beta-D-glucopyranoside 0
                                          1-O-sinapoyl-beta-D-glucose 0
                                          1-[(3,4-dimethoxyphenyl)-[1-(2-methoxyethyl)-5-tetrazolyl]methyl]-2,3-dihydroindole 0
                                          1-[(3,4-dimethoxyphenyl)methyl]-4-(4-hydroxyphenyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester 0
                                          1-[2-(3,4-dimethoxyphenyl)-1-oxoethyl]-4-piperidinecarboxylic acid methyl ester 0
                                          1-[2-(3,4-dimethoxyphenyl)ethyl]-6-propyl-2-sulfanylidene-7,8-dihydro-5H-pyrimido[4,5-d]pyrimidin-4-one 0
                                          1-[4-(3,5-dimethoxyphenyl)-2-thiazolyl]-4-piperidinecarboxamide 0
                                          1-[[(2R,3S)-8-[2-(3,4-dimethoxyphenyl)ethynyl]-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-3,4-dihydro-2H-pyrido[2,3-b][1,5]oxazocin-2-yl]methyl]-3-(3,5-dimethyl-4-isoxazolyl)-1-methylurea 0
                                          1-cyclohexyl-3-[1-(3,4-dimethoxyphenyl)ethyl]thiourea 0
                                          1-cyclohexyl-5-[1-(2,4-dimethoxyanilino)ethylidene]-1,3-diazinane-2,4,6-trione 0
                                          2',6'-dimethoxy-4'-hydroxyacetophenone 0
                                          2'-O-methylodoratol 0
                                          2,3-diacetoxypropioveratrone 0
                                          2,4-dimethoxy-N-(5-nitro-2-pyridinyl)benzamide 0
                                          2,5-bis[(3,4-dimethoxyphenyl)methylidene]-1-cyclopentanone 0
                                          2,6-dimethoxyphenol + 0
                                          2,6-dimethoxyphenol acetate 0
                                          2-(1H-benzimidazol-2-yl)-4-(3,4-dimethoxyphenyl)-3-oxobutanenitrile 0
                                          2-(2,3-dimethoxyphenyl)-3-(4-methoxyphenyl)-4-thiazolidinone 0
                                          2-(2,4-dimethoxyphenyl)acetic acid 0
                                          2-(2,5-dimethoxyphenyl)-5-(5-methyl-2-furanyl)-1,3,4-oxadiazole 0
                                          2-(2,5-dimethoxyphenyl)ethanamine 0
                                          2-(3,4-dimethoxyphenyl)-1-[5-hydroxy-3-methyl-5-(trifluoromethyl)-4H-pyrazol-1-yl]ethanone 0
                                          2-(3,4-dimethoxyphenyl)-8-methoxy-4,4-dimethyl-5H-isothiazolo[5,4-c]quinoline-1-thione 0
                                          2-(3,4-dimethoxyphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methylethanamine 0
                                          2-(3,4-dimethoxyphenyl)-N-[3-(3-nitrophenyl)prop-2-enylideneamino]acetamide 0
                                          2-(4-bromophenyl)-N-[(2-chloro-3,4-dimethoxyphenyl)methyl]-1-cyclopropanamine 0
                                          2-(4-hydroxy-3,5-dimethoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-7H-pyrano[2,3-g][1,4]benzodioxin-7-one 0
                                          2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine 28
                                          2-Chloro-1-[5-(3,4-dimethoxyphenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-one 0
                                          2-[(2,4-dimethoxyphenyl)methylidene]-6-methylthiazolo[3,2-b][1,2,4]triazine-3,7-dione 0
                                          2-[(2,4-dimethoxyphenyl)methylideneamino]-1-nitroguanidine 0
                                          2-[(2,5-dimethoxyanilino)methylidene]-1-cyclohexanone 0
                                          2-[(4-bromophenoxy)methyl]-5-[2-(3,4-dimethoxyphenyl)ethylamino]-4-oxazolecarbonitrile 0
                                          2-[2-(2,3-dimethoxyphenyl)-4-thiazolyl]acetic acid 0
                                          2-[4-(heptylthio)-2,5-dimethoxyphenyl]-N-methylethanamine 0
                                          2-[[(2,3-dimethoxyphenyl)-oxomethyl]amino]-5-propan-2-yl-3-thiophenecarboxamide 0
                                          2-[[(3,4-dimethoxyphenyl)-oxomethyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide 0
                                          2-[[(3,4-dimethoxyphenyl)-oxomethyl]amino]-N-(2-furanylmethyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide 0
                                          2-[[2-(3,4-dimethoxyanilino)-2-oxoethyl]thio]-3-pyridinecarboxylic acid propan-2-yl ester 0
                                          2-[[3-[2-(3,4-dimethoxyphenyl)ethyl]-4-oxo-2-thieno[3,2-d]pyrimidinyl]thio]-N-(5-methyl-3-isoxazolyl)acetamide 0
                                          2-[[5-cyano-2-(3,4-dimethoxyphenyl)-4-oxo-2,3-dihydro-1,3-thiazin-6-yl]thio]acetic acid ethyl ester 0
                                          2-amino-1-(3,4-dimethoxyphenyl)ethanol 0
                                          2-fluoro-N-(1-hydroxy-2-methylpropan-2-yl)-4,5-dimethoxybenzamide 0
                                          2-furancarboxylic acid [[amino-(3,4-dimethoxyphenyl)methylidene]amino] ester 0
                                          3',6'-dihydroxy-2',4,4'-trimethoxy-chalcone 0
                                          3,3''-dihydroxyterphenyllin 0
                                          3,4-dimethoxy cinnamaldehyde 0
                                          3,4-dimethoxy-N-(2-methyl-1,3-benzothiazol-6-yl)benzamide 0
                                          3,4-dimethoxy-N-(3-methyl-1,3-benzothiazol-2-ylidene)benzamide 0
                                          3,4-dimethoxy-N-[[2-(4-morpholinyl)-4-phenyl-5-thiazolyl]methylideneamino]benzamide 0
                                          3,4-dimethoxy-N-[[[oxo(2-pyrazinyl)methyl]hydrazo]-sulfanylidenemethyl]benzamide 0
                                          3,4-dimethoxybenzenecarbothioic acid S-(4-chlorophenyl) ester 0
                                          3,4-dimethoxybenzyl acetate 0
                                          3,4-dimethoxycinnamyl acetate 0
                                          3,4-dimethoxycinnamyl alcohol 0
                                          3,5-dimethoxy-N-(1H-1,2,4-triazol-5-yl)benzamide 0
                                          3,5-dimethoxy-N-[(2-phenylethylamino)-sulfanylidenemethyl]benzamide 0
                                          3,5-dimethoxy-N-[2-(4-morpholinyl)ethyl]benzamide 0
                                          3-(2,4-dimethoxyphenyl)-6-phenyl-2-sulfanylidene-1H-thieno[2,3-d]pyrimidin-4-one 0
                                          3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-[4-(diethylamino)butylamino]-1-methyl-4H-pyrimido[4,5-d]pyrimidin-2-one 0
                                          3-(3,4,5-trimethoxyphenyl)propanoic acid [2-(3,5-dimethoxyanilino)-2-oxoethyl] ester 0
                                          3-(3,4-dimethoxyphenyl)-2-(3-pyridinyl)-2-propenenitrile 0
                                          3-(3,4-dimethoxyphenyl)propanoic acid 0
                                          3-(4-chlorophenyl)-2-(2,3-dimethoxyphenyl)-4-thiazolidinone 0
                                          3-[7-(2,4-dimethoxyphenyl)-1,4-thiazepan-5-ylidene]-6-methylpyran-2,4-dione 0
                                          3-bromo-N-[(2,4-dimethoxyphenyl)methylideneamino]benzamide 0
                                          3-bromo-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2,6-dimethoxybenzamide 2
                                          3-heptadecylveratrole 0
                                          3-hydroxyterphenyllin + 0
                                          4''-dehydro-3-hydroxyterphenyllin 0
                                          4''-deoxyterphenyllin 0
                                          4-(2,4-dimethoxyphenyl)-3-methyl-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one 0
                                          4-(3,4-dimethoxyphenyl)-1-(2-methoxyethyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester 0
                                          4-(3,4-dimethoxyphenyl)-2-thiophen-2-ylthiazole 0
                                          4-(3,4-dimethoxyphenyl)-N-(3-methyl-2-pyridinyl)-2-thiazolamine 0
                                          4-O-beta-D-glucosyl-trans-sinapic acid 0
                                          4-[2-(2,3-dimethoxyphenyl)ethenyl]pyridine 0
                                          4-[2-(2,4-dimethoxyanilino)-2-oxoethyl]-5-thieno[3,2-b]pyrrolecarboxylic acid ethyl ester 0
                                          4-[2-(allyloxy)vinyl]-1,2-dimethoxybenzene 0
                                          4-acetoxy-3,5-dimethoxy-trans-cinnamaldehyde 0
                                          4-allyl-2,6-dimethoxyphenol 0
                                          4-amino-N'-[(3,4-dimethoxyphenyl)methylideneamino]-1,2,5-oxadiazole-3-carboximidamide 0
                                          4-chloro-N-(4-chloro-2,5-dimethoxyphenyl)-5-dithiazolimine 0
                                          4-hydroxy-5-propionyl-1,3-di-O-methylpyrogallol 0
                                          4-morpholinecarboxylic acid [4-(2-amino-3-cyano-5-oxo-4,6,7,8-tetrahydro-1-benzopyran-4-yl)-2,6-dimethoxyphenyl] ester 0
                                          5''-methoxyhydnocarpin-D 0
                                          5-(2,4-dimethoxyphenyl)-7-(3,4-dimethoxyphenyl)-1,7-dihydrotetrazolo[1,5-a]pyrimidine 0
                                          5-(3,4-dimethoxyphenyl)-2-(4-methylphenyl)-4-thieno[2,3-d][1,3]oxazinone 0
                                          5-(3,4-dimethoxyphenyl)-2-methyl-4-(4-methyl-1-piperidinyl)thieno[2,3-d]pyrimidine 0
                                          5-(3,4-dimethoxyphenyl)-2-methylsulfonyl-3-thiophen-2-yl-3,4-dihydropyrazole 0
                                          5-(3,4-dimethoxyphenyl)-2-phenyl-4-thieno[2,3-d][1,3]oxazinone 0
                                          5-(3,4-dimethoxyphenyl)-N-(3-pyridinyl)-3-isoxazolecarboxamide 0
                                          5-(3,4-dimethoxyphenyl)-N-[1-[(2-methylphenyl)methyl]-4-pyrazolyl]-3-isoxazolecarboxamide 0
                                          5-[(3,4-dimethoxyphenyl)-[4-(2-hydroxyethyl)-1-piperazinyl]methyl]-2-methyl-6-thiazolo[3,2-b][1,2,4]triazolol 0
                                          5-[(3,4-dimethoxyphenyl)methyl]-1-prop-2-enyl-1,3-diazinane-2,4,6-trione 0
                                          5-[(3,4-dimethoxyphenyl)methylidene]-3-(phenylmethyl)-2-(phenylmethyl)imino-4-thiazolidinone 0
                                          5-[(4,5-dimethoxy-2-methylphenyl)methyl]pyrimidine-2,4-diamine 0
                                          5-[1-[(3,5-dimethoxyphenyl)methylamino]ethylidene]-1-prop-2-enyl-1,3-diazinane-2,4,6-trione 0
                                          5-[1-[(3,5-dimethoxyphenyl)methylamino]propylidene]-1-prop-2-enyl-1,3-diazinane-2,4,6-trione 0
                                          5-[2-(3,4-dimethoxyphenyl)ethylamino]-2-[(2-fluorophenoxy)methyl]-4-oxazolecarbonitrile 0
                                          5-[2-[(3,4-dimethoxyphenyl)methylidene]hydrazinyl]-6-methyl-2H-1,2,4-triazin-3-one 0
                                          5-amino-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-4-triazolecarboxamide 0
                                          5-amino-1-[(4-chlorophenyl)methyl]-4-[4-(3,4-dimethoxyphenyl)-2-thiazolyl]-2H-pyrrol-3-one 0
                                          6-(chloromethyl)-N2-(2,5-dimethoxyphenyl)-1,3,5-triazine-2,4-diamine 0
                                          6-[(3,4-dimethoxyphenyl)methyl]-3-[(2-hydroxy-4-oxo-1-cyclohexa-2,5-dienylidene)methylhydrazo]-2H-1,2,4-triazin-5-one 0
                                          6-[3-(3,4-dimethoxyphenyl)-1H-pyrazolo[1,5-a]pyrimidin-5-ylidene]-1-cyclohexa-2,4-dienone 0
                                          6-amino-1-[2-(3,4-dimethoxyphenyl)ethyl]-2-sulfanylidene-4-pyrimidinone 0
                                          6-amino-4-(2,4-dimethoxyphenyl)-3-propyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile 0
                                          6-amino-5-cyano-4-(2,4-dimethoxyphenyl)-2-(2-ethoxy-2-oxoethyl)-4H-pyran-3-carboxylic acid ethyl ester 0
                                          6-chloro-N4-[(3,4-dimethoxyphenyl)methylideneamino]pyrimidine-4,5-diamine 0
                                          7-(2,3-dimethoxyphenyl)-5-(trifluoromethyl)-1,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylic acid ethyl ester 0
                                          7-(2,5-dimethoxyphenyl)-5-(trifluoromethyl)-1,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylic acid ethyl ester 0
                                          D617 0
                                          HG-9-91-01 0
                                          LSM-32019 0
                                          Methoxamine hydrochloride 0
                                          N-(1,3-benzothiazol-2-yl)-2-[(3,4-dimethoxyphenyl)methylideneamino]oxyacetamide 0
                                          N-(1H-indazol-6-yl)-2,4-dimethoxybenzamide 0
                                          N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-2-(2,3-dimethoxyphenyl)acetamide 0
                                          N-(2,4-dimethoxyphenyl)-N'-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]butanediamide 0
                                          N-(2,5-dimethoxyphenyl)-4-(2,4-dimethyl-5-thiazolyl)-2-thiazolamine 0
                                          N-(2-carbamoylphenyl)-2-(2,5-dimethoxyphenyl)quinoline-4-carboxamide 0
                                          N-(3,4-dimethoxyphenyl)-2-[(4-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-2-yl)thio]acetamide 0
                                          N-(3,4-dimethoxyphenyl)-3-(3-methoxyphenyl)-4,5-dihydroisoxazole-5-carboxamide 0
                                          N-(3,4-dimethoxyphenyl)-6-phenyl-4-thieno[2,3-d]pyrimidinamine 0
                                          N-[(2,5-dimethoxyphenyl)methylideneamino]-1-methyl-6-oxo-3-pyridinecarboxamide 0
                                          N-[(2,5-dimethoxyphenyl)methylideneamino]-5-[(4-nitro-1-pyrazolyl)methyl]-2-furancarboxamide 0
                                          N-[(3,4-dimethoxyphenyl)methyl]-3-(2-pyrimidinylthio)-1-propanamine 0
                                          N-[(3,4-dimethoxyphenyl)methyl]-N-methyl-2-(2-pyridinyl)ethanamine 0
                                          N-[(3,5-dimethoxyphenyl)methyl]-1-(2,3,4-trimethoxyphenyl)methanamine 0
                                          N-[(3,5-dimethoxyphenyl)methyl]-1-[4-(methylthio)phenyl]methanamine 0
                                          N-[1-(1H-benzimidazol-2-yl)-2-thiophen-2-ylethenyl]-3,4-dimethoxybenzamide 0
                                          N-[1-[(4-chlorophenyl)methyl]-5-methyl-3-pyrazolyl]-5-(2,5-dimethoxyphenyl)-3-isoxazolecarboxamide 0
                                          N-[1-[(4-chlorophenyl)methyl]-5-methyl-3-pyrazolyl]-5-(3,4-dimethoxyphenyl)-3-isoxazolecarboxamide 0
                                          N-[2-(3,4-dimethoxyphenyl)ethyl]-2-[(4-methylphenyl)thio]propanamide 0
                                          N-[2-(3,4-dimethoxyphenyl)ethyl]-2-[3-(4-fluorophenyl)-2,4-dioxo-1-thieno[3,2-d]pyrimidinyl]acetamide 0
                                          N-[2-(3,4-dimethoxyphenyl)ethyl]-2-[[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]thio]acetamide 0
                                          N-[2-(3,4-dimethoxyphenyl)ethyl]-4-(2,4-dimethyl-5-thiazolyl)-2-thiazolamine 0
                                          N-[2-(3,4-dimethoxyphenyl)ethyl]-4-[[[3,4-dioxo-2-(1-pyrrolidinyl)-1-cyclobutenyl]amino]methyl]-1-cyclohexanecarboxamide 0
                                          N-[2-(3,4-dimethoxyphenyl)ethyl]-5-thiophen-2-yl-3-isoxazolecarboxamide 0
                                          N-[2-[2-[(3,4-dimethoxyphenyl)methylidene]hydrazinyl]-4-(4-methylphenyl)-5-thiazolyl]acetamide 0
                                          N-[3-(4-\{[1-(5-chloro-2,4-dimethoxyanilino)-1-oxopropan-2-yl]sulfanyl\}anilino)-3-oxo-1-phenylprop-1-en-2-yl]benzamide 0
                                          N-[4-(2,5-dimethoxyphenyl)-2-thiazolyl]-2-[(4-nitrophenyl)thio]acetamide 0
                                          N-[4-(2,5-dimethoxyphenyl)-2-thiazolyl]-N-(2-oxolanylmethyl)cyclohexanecarboxamide 0
                                          N-[5-(2,4-dimethoxyphenyl)-1,3,4-thiadiazol-2-yl]-2-phenylacetamide 0
                                          N-[5-(3,4-dimethoxyphenyl)-1,3,4-thiadiazol-2-yl]carbamic acid ethyl ester 0
                                          N-[5-[(3,4-dimethoxyphenyl)methyl]-1,3,4-thiadiazol-2-yl]-4-methoxybenzamide 0
                                          N-[5-[2-(2,5-dimethoxyanilino)-4-thiazolyl]-4-methyl-2-thiazolyl]-2-methylpentanamide 0
                                          N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-5-iodo-2,3-dimethoxybenzamide 0
                                          N-tert-butyl-2-[[5-(3,5-dimethoxyphenyl)-1,3,4-oxadiazol-2-yl]thio]-N-(phenylmethyl)acetamide 0
                                          N2-[(3,4-dimethoxyphenyl)methylideneamino]-N4-phenyl-6-(1-piperidinyl)-1,3,5-triazine-2,4-diamine 0
                                          N3,N6-bis(2,5-dimethoxyphenyl)pyridazine-3,6-diamine 0
                                          N4-(2,5-dimethoxyphenyl)-N2-(3-methylbutyl)-5-nitropyrimidine-2,4,6-triamine 0
                                          PD-166866 + 21
                                          PD173074 18
                                          [4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-(2,6-dimethoxyphenyl)methanone 0
                                          [5-(2,5-dimethoxyphenyl)-3-isoxazolyl]-(4-morpholinyl)methanone 0
                                          acetosyringone + 0
                                          acetosyringone acetate 0
                                          acetoveratrone 0
                                          acuminatin 0
                                          belladine 0
                                          beta-hibitakanine 0
                                          bihapten 1 dimethyl ether 0
                                          brugunin A 0
                                          buddlenol A 0
                                          buddlenol B 0
                                          buddlenol C 0
                                          chloroneb 0
                                          cryogenine 0
                                          danielone 0
                                          decimemide 0
                                          demethoxyaschantin 0
                                          denopamine 2
                                          ficusequilignan A 0
                                          flavokawain B 18
                                          futokadsurin B 0
                                          futokadsurin C 0
                                          galgravin 0
                                          griffithane A 0
                                          griffithane B 0
                                          griffithane C 0
                                          homoveratric acid 0
                                          isomethyleugenol + 6
                                          kadsurenin C 0
                                          kadsurenin L 0
                                          kadsurenin M 0
                                          lignin cw compound-147 0
                                          manassantin A 0
                                          manassantin B 0
                                          methyl syringate 0
                                          methyl-3,4-dimethoxycinnamate 0
                                          papaverine 14
                                          prenylterphenyllin 0
                                          prenylterphenyllin A 0
                                          prenylterphenyllin B 0
                                          prenylterphenyllin C 0
                                          rel-(+)-(7'S,8S,8'S)-4,4'-dihydroxy-3',5,5'-trimethoxy-2,7'-cyclolignan 0
                                          rel-(-)-(7S,7'R,8S,8'R)-4,4'-dihydroxy-3,3',5'-trimethoxy-7,7'-epoxylignan 0
                                          simulanol 0
                                          sinapic acid + 11
                                          sinapyl alcohol + 0
                                          syringaldehyde + 0
                                          syringaldehyde acetate 0
                                          syringic acid + 3
                                          syringic acid acetate 0
                                          syringin 0
                                          syringyl alcohol + 0
                                          syringyl alcohol diacetate 0
                                          syringylglycerol beta-guaiacyl ether 0
                                          syringylresinol diacetate 0
                                          terphenyllin + 0
                                          terprenin 0
                                          tetroxoprim 0
                                          tranilast 5
                                          trans-sinapyl actetate 0
                                          vaccihein A 0
                                          veratraldehyde 0
                                          veratrole + 0
                                          veratrone + 0
                                          veratrone acetate 0
                                          veratryl alcohol methyl ether 0
                                          veratryl glycerol + 0
                                          veratrylglycerol beta-guaiacyl ether 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.