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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dihydrofuran
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Accession:CHEBI:51659 term browser browse the term
Definition:Compounds containing a mono-unsaturated furan ring skeleton.
Synonyms:related_synonym: dihydrofurans



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stavudine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases expression EXP Stavudine results in increased expression of ABCB1 mRNA CTD PMID:18310046 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing decreases expression EXP
ISO
Stavudine results in decreased expression of ADIPOQ protein
Stavudine results in decreased expression of ADIPOQ mRNA; Stavudine results in decreased expression of ADIPOQ protein
CTD PMID:15865214 PMID:17503663 PMID:17668557 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
JBrowse link
G ALB albumin affects binding EXP Stavudine binds to ALB protein CTD PMID:15814459 PMID:16336266 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G ATP5F1E ATP synthase F1 subunit epsilon decreases expression ISO Stavudine results in decreased expression of ATP5F1E mRNA CTD PMID:18299183 NCBI chr20:59,025,475...59,032,335
Ensembl chr20:59,025,475...59,032,345
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP Stavudine results in decreased expression of BCL2 protein CTD PMID:9007205 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 increases expression ISO Stavudine results in increased expression of BCL2L1 mRNA CTD PMID:18299183 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G CASP3 caspase 3 increases cleavage ISO Stavudine results in increased cleavage of CASP3 protein CTD PMID:32278789 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CCL2 C-C motif chemokine ligand 2 increases expression EXP Stavudine results in increased expression of CCL2 protein CTD PMID:17668557 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A affects expression ISO Stavudine affects the expression of CDKN1A protein CTD PMID:18389896 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337
JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A affects expression ISO Stavudine affects the expression of CDKN2A protein CTD PMID:18389896 NCBI chr 9:21,967,752...21,995,324
Ensembl chr 9:21,967,752...21,995,301
JBrowse link
G CEBPA CCAAT enhancer binding protein alpha decreases expression ISO Stavudine results in decreased expression of CEBPA protein CTD PMID:15722030 NCBI chr19:33,299,934...33,302,534
Ensembl chr19:33,299,934...33,302,534
JBrowse link
G CEBPB CCAAT enhancer binding protein beta increases expression ISO Stavudine results in increased expression of CEBPB mRNA CTD PMID:18299183 NCBI chr20:50,190,583...50,192,690
Ensembl chr20:50,190,830...50,192,668
JBrowse link
G CHEK1 checkpoint kinase 1 increases phosphorylation ISO Stavudine results in increased phosphorylation of CHEK1 protein CTD PMID:32278789 NCBI chr11:125,625,136...125,681,124
Ensembl chr11:125,625,163...125,676,255
JBrowse link
G CPT1A carnitine palmitoyltransferase 1A increases expression ISO Stavudine results in increased expression of CPT1A mRNA CTD PMID:14576092 NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410
JBrowse link
G FASN fatty acid synthase multiple interactions
decreases expression
ISO [Stavudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of FASN mRNA; [Stavudine co-treated with Lamivudine] results in increased expression of FASN mRNA
Stavudine results in decreased expression of FASN protein
CTD PMID:11741158 PMID:15722030 NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294
JBrowse link
G FTH1 ferritin heavy chain 1 increases expression ISO Stavudine results in increased expression of FTH1 mRNA CTD PMID:18299183 NCBI chr11:61,964,285...61,967,634
Ensembl chr11:61,959,718...61,967,634
JBrowse link
G GAN gigaxonin decreases expression ISO Stavudine results in decreased expression of GAN mRNA; Stavudine results in decreased expression of GAN protein CTD PMID:19398414 NCBI chr16:81,314,962...81,390,809
Ensembl chr16:81,314,944...81,390,809
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases expression ISO Stavudine results in increased expression of GCLC mRNA CTD PMID:18299183 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GPX4 glutathione peroxidase 4 decreases expression ISO Stavudine results in decreased expression of GPX4 mRNA CTD PMID:18299183 NCBI chr19:1,103,994...1,106,779
Ensembl chr19:1,103,982...1,106,791
JBrowse link
G GSTA1 glutathione S-transferase alpha 1 increases expression ISO Stavudine results in increased expression of GSTA1 mRNA CTD PMID:18299183 NCBI chr 6:52,791,371...52,803,816
Ensembl chr 6:52,791,371...52,803,860
JBrowse link
G GSTP1 glutathione S-transferase pi 1 increases expression ISO Stavudine results in increased expression of GSTP1 mRNA CTD PMID:18299183 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G HFE homeostatic iron regulator multiple interactions EXP HFE gene SNP affects the susceptibility to [Didanosine co-treated with Stavudine] CTD PMID:16847405 NCBI chr 6:26,087,429...26,098,343
Ensembl chr 6:26,087,281...26,098,343
JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 affects expression EXP Stavudine affects the expression of HSPD1 protein CTD PMID:27041070 NCBI chr 2:197,486,584...197,500,274
Ensembl chr 2:197,486,584...197,516,737
JBrowse link
G IGFBP1 insulin like growth factor binding protein 1 increases expression ISO Stavudine results in increased expression of IGFBP1 mRNA CTD PMID:18299183 NCBI chr 7:45,888,488...45,893,660
Ensembl chr 7:45,888,360...45,893,660
JBrowse link
G IL1B interleukin 1 beta increases expression EXP Stavudine results in increased expression of IL1B protein CTD PMID:17668557 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 increases expression EXP Stavudine results in increased expression of IL6 protein CTD PMID:17668557 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO Stavudine results in increased expression of JUN mRNA CTD PMID:18299183 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
JBrowse link
G LEP leptin decreases expression EXP Stavudine results in decreased expression of LEP protein CTD PMID:17668557 NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629
JBrowse link
G LONP1 lon peptidase 1, mitochondrial affects expression EXP Stavudine affects the expression of LONP1 protein CTD PMID:27041070 NCBI chr19:5,691,834...5,720,452
Ensembl chr19:5,691,834...5,720,572
JBrowse link
G LPL lipoprotein lipase multiple interactions ISO [Stavudine co-treated with Lamivudine co-treated with Indinavir] affects the expression of LPL mRNA; [Stavudine co-treated with Lamivudine co-treated with Nelfinavir] results in decreased expression of LPL mRNA; [Stavudine co-treated with Lamivudine] affects the expression of LPL mRNA CTD PMID:11741158 NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 decreases phosphorylation EXP Stavudine results in decreased phosphorylation of MAPK8 protein CTD PMID:27041070 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G ME1 malic enzyme 1 multiple interactions
increases expression
ISO [Stavudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ME1 mRNA; [Stavudine co-treated with Lamivudine co-treated with Nelfinavir] results in decreased expression of ME1 mRNA; [Stavudine co-treated with Lamivudine] results in increased expression of ME1 mRNA
Stavudine results in increased expression of ME1 mRNA
CTD PMID:11741158 NCBI chr 6:83,210,402...83,431,051
Ensembl chr 6:83,210,402...83,431,051
JBrowse link
G MTTP microsomal triglyceride transfer protein multiple interactions
decreases expression
ISO Carnitine inhibits the reaction [Stavudine results in decreased expression of MTTP mRNA] CTD PMID:18299183 NCBI chr 4:99,564,130...99,623,997
Ensembl chr 4:99,564,081...99,623,997
JBrowse link
G NRF1 nuclear respiratory factor 1 increases expression ISO Stavudine results in increased expression of NRF1 mRNA CTD PMID:17926646 NCBI chr 7:129,611,720...129,757,076
Ensembl chr 7:129,611,720...129,757,082
JBrowse link
G PCNA proliferating cell nuclear antigen increases expression
decreases expression
ISO Stavudine results in increased expression of PCNA mRNA
Stavudine results in decreased expression of PCNA protein
CTD PMID:18299183 PMID:32278789 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma decreases expression EXP
ISO
Stavudine results in decreased expression of PPARG mRNA
Stavudine results in decreased expression of PPARG mRNA; Stavudine results in decreased expression of PPARG protein
CTD PMID:14518702 PMID:15722030 PMID:17926646 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Stavudine results in decreased expression of PTGS2 protein CTD PMID:18389896 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G SIRT3 sirtuin 3 increases expression EXP Stavudine results in increased expression of SIRT3 protein CTD PMID:27041070 NCBI chr11:215,030...236,931
Ensembl chr11:215,030...236,931
JBrowse link
G SLC25A19 solute carrier family 25 member 19 multiple interactions EXP SLC25A19 protein affects the susceptibility to [Stavudine co-treated with Lamivudine co-treated with Indinavir] CTD PMID:15951836 NCBI chr17:75,272,992...75,289,433
Ensembl chr17:75,272,981...75,289,510
JBrowse link
G SLC25A5 solute carrier family 25 member 5 increases expression ISO Stavudine results in increased expression of SLC25A5 mRNA CTD PMID:18299183 NCBI chr  X:119,468,444...119,471,396
Ensembl chr  X:119,468,422...119,471,396
JBrowse link
G SLC29A3 solute carrier family 29 member 3 affects transport EXP SLC29A3 protein affects the transport of Stavudine CTD PMID:19164483 NCBI chr10:71,319,259...71,381,423
Ensembl chr10:71,319,259...71,381,423
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions
increases expression
ISO Carnitine inhibits the reaction [Stavudine results in increased expression of SREBF1 mRNA] CTD PMID:18299183 NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002
JBrowse link
G STAT3 signal transducer and activator of transcription 3 decreases expression ISO Stavudine results in decreased expression of STAT3 mRNA CTD PMID:18299183 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568
JBrowse link
G TFAP2A transcription factor AP-2 alpha decreases expression ISO Stavudine results in decreased expression of TFAP2A mRNA CTD PMID:17926646 NCBI chr 6:10,396,677...10,419,659
Ensembl chr 6:10,393,186...10,419,659
JBrowse link
G TNF tumor necrosis factor increases expression EXP Stavudine results in increased expression of TNF protein CTD PMID:17668557 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TYMP thymidine phosphorylase increases expression EXP Stavudine results in increased expression of TYMP protein CTD PMID:16457948 NCBI chr22:50,525,752...50,530,085
Ensembl chr22:50,525,752...50,530,032
JBrowse link
G UCP1 uncoupling protein 1 decreases expression
increases expression
ISO
EXP
Stavudine results in decreased expression of UCP1 mRNA
Stavudine results in increased expression of UCP1
CTD PMID:16038477 PMID:17926646 NCBI chr 4:140,559,431...140,568,961
Ensembl chr 4:140,559,431...140,568,961
JBrowse link
G UCP2 uncoupling protein 2 decreases expression EXP Stavudine results in decreased expression of UCP2 mRNA CTD PMID:14518702 NCBI chr11:73,974,672...73,983,202
Ensembl chr11:73,974,672...73,982,843
JBrowse link
G UCP3 uncoupling protein 3 decreases expression EXP Stavudine results in decreased expression of UCP3 mRNA CTD PMID:14518702 NCBI chr11:74,000,277...74,009,085
Ensembl chr11:74,000,277...74,009,085
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26040
    chemical entity 26019
      atom 26015
        nonmetal atom 25504
          oxygen atom 24814
            oxygen molecular entity 24814
              organooxygen compound 24061
                oxacycle 19968
                  furans 8669
                    dihydrofuran 49
                      (+)-2,4-dimethyl-4,5-dihydrofuran-3-carbaldehyde 0
                      (2'R)-atrovenetin(1-) 0
                      2,3-dihydrofuran 0
                      3-methyl-2,3-dihydrofuran + 0
                      4-methyl-2,3-dihydrofuran 0
                      5-methyl-2,3-dihydrofuran + 0
                      Cadopherone B 0
                      Chrysorrhelactone 0
                      Dahliane A 0
                      Dahliane B 0
                      Decarestrictine I 0
                      Dihydro-2-methyl-3(2H)-furanthione 0
                      Etaspirene 0
                      Genipic acid 0
                      Guanacastepene I 0
                      Harposporin A 0
                      Isosarcophytoxides mixture 0
                      Libertellenone E 0
                      Libertellenone F 0
                      Mycosinol 0
                      Phaeofuran B 0
                      Phomactin G 0
                      Phomopoxide F 0
                      Phomopoxide G 0
                      Plicatilisin D 0
                      Plicatilisin H 0
                      Radianspene E 0
                      S-(4,5-dihydro-2-methyl-3-furanyl) ethanethioate 0
                      Saponaroxin A 0
                      Sch 49028 0
                      Secovironolide 0
                      [4-[(E)-3-[(2-hydroxy-5-oxocyclopenten-1-yl)amino]-3-oxoprop-1-enyl]-2,3-dihydrouran-2-yl] acetate 0
                      bis(2-methyl-4,5-dihydro-3-furyl) disulfide 0
                      furanomycin 0
                      herqueinone(1-) 0
                      stavudine 49
Path 2
Term Annotations click to browse term
  CHEBI ontology 26040
    subatomic particle 26015
      composite particle 26015
        hadron 26015
          baryon 26015
            nucleon 26015
              atomic nucleus 26015
                atom 26015
                  main group element atom 25840
                    p-block element atom 25840
                      carbon group element atom 25441
                        carbon atom 25399
                          organic molecular entity 25399
                            organic molecule 25228
                              organic cyclic compound 24279
                                organic heterocyclic compound 22322
                                  organic heteromonocyclic compound 19239
                                    furans 8669
                                      dihydrofuran 49
                                        (+)-2,4-dimethyl-4,5-dihydrofuran-3-carbaldehyde 0
                                        (2'R)-atrovenetin(1-) 0
                                        2,3-dihydrofuran 0
                                        3-methyl-2,3-dihydrofuran + 0
                                        4-methyl-2,3-dihydrofuran 0
                                        5-methyl-2,3-dihydrofuran + 0
                                        Cadopherone B 0
                                        Chrysorrhelactone 0
                                        Dahliane A 0
                                        Dahliane B 0
                                        Decarestrictine I 0
                                        Dihydro-2-methyl-3(2H)-furanthione 0
                                        Etaspirene 0
                                        Genipic acid 0
                                        Guanacastepene I 0
                                        Harposporin A 0
                                        Isosarcophytoxides mixture 0
                                        Libertellenone E 0
                                        Libertellenone F 0
                                        Mycosinol 0
                                        Phaeofuran B 0
                                        Phomactin G 0
                                        Phomopoxide F 0
                                        Phomopoxide G 0
                                        Plicatilisin D 0
                                        Plicatilisin H 0
                                        Radianspene E 0
                                        S-(4,5-dihydro-2-methyl-3-furanyl) ethanethioate 0
                                        Saponaroxin A 0
                                        Sch 49028 0
                                        Secovironolide 0
                                        [4-[(E)-3-[(2-hydroxy-5-oxocyclopenten-1-yl)amino]-3-oxoprop-1-enyl]-2,3-dihydrouran-2-yl] acetate 0
                                        bis(2-methyl-4,5-dihydro-3-furyl) disulfide 0
                                        furanomycin 0
                                        herqueinone(1-) 0
                                        stavudine 49
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