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G |
ABCB1 |
ATP binding cassette subfamily B member 1 |
increases expression |
EXP |
Stavudine results in increased expression of ABCB1 mRNA |
CTD |
PMID:18310046 |
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NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
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G |
ADIPOQ |
adiponectin, C1Q and collagen domain containing |
decreases expression |
EXP ISO |
Stavudine results in decreased expression of ADIPOQ protein Stavudine results in decreased expression of ADIPOQ mRNA; Stavudine results in decreased expression of ADIPOQ protein |
CTD |
PMID:15865214 PMID:17503663 PMID:17668557 |
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NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
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G |
ALB |
albumin |
affects binding |
EXP |
Stavudine binds to ALB protein |
CTD |
PMID:15814459 PMID:16336266 |
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NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
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G |
ATP5F1E |
ATP synthase F1 subunit epsilon |
decreases expression |
ISO |
Stavudine results in decreased expression of ATP5F1E mRNA |
CTD |
PMID:18299183 |
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NCBI chr20:59,025,475...59,032,335
Ensembl chr20:59,025,475...59,032,345
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G |
BCL2 |
BCL2 apoptosis regulator |
decreases expression |
EXP |
Stavudine results in decreased expression of BCL2 protein |
CTD |
PMID:9007205 |
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NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
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G |
BCL2L1 |
BCL2 like 1 |
increases expression |
ISO |
Stavudine results in increased expression of BCL2L1 mRNA |
CTD |
PMID:18299183 |
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NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
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G |
CASP3 |
caspase 3 |
increases cleavage |
ISO |
Stavudine results in increased cleavage of CASP3 protein |
CTD |
PMID:32278789 |
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NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
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G |
CCL2 |
C-C motif chemokine ligand 2 |
increases expression |
EXP |
Stavudine results in increased expression of CCL2 protein |
CTD |
PMID:17668557 |
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NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208
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G |
CDKN1A |
cyclin dependent kinase inhibitor 1A |
affects expression |
ISO |
Stavudine affects the expression of CDKN1A protein |
CTD |
PMID:18389896 |
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NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337
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G |
CDKN2A |
cyclin dependent kinase inhibitor 2A |
affects expression |
ISO |
Stavudine affects the expression of CDKN2A protein |
CTD |
PMID:18389896 |
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NCBI chr 9:21,967,752...21,995,324
Ensembl chr 9:21,967,752...21,995,301
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G |
CEBPA |
CCAAT enhancer binding protein alpha |
decreases expression |
ISO |
Stavudine results in decreased expression of CEBPA protein |
CTD |
PMID:15722030 |
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NCBI chr19:33,299,934...33,302,534
Ensembl chr19:33,299,934...33,302,534
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G |
CEBPB |
CCAAT enhancer binding protein beta |
increases expression |
ISO |
Stavudine results in increased expression of CEBPB mRNA |
CTD |
PMID:18299183 |
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NCBI chr20:50,190,583...50,192,690
Ensembl chr20:50,190,830...50,192,668
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G |
CHEK1 |
checkpoint kinase 1 |
increases phosphorylation |
ISO |
Stavudine results in increased phosphorylation of CHEK1 protein |
CTD |
PMID:32278789 |
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NCBI chr11:125,625,136...125,681,124
Ensembl chr11:125,625,163...125,676,255
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G |
CPT1A |
carnitine palmitoyltransferase 1A |
increases expression |
ISO |
Stavudine results in increased expression of CPT1A mRNA |
CTD |
PMID:14576092 |
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NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410
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G |
FASN |
fatty acid synthase |
multiple interactions decreases expression |
ISO |
[Stavudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of FASN mRNA; [Stavudine co-treated with Lamivudine] results in increased expression of FASN mRNA Stavudine results in decreased expression of FASN protein |
CTD |
PMID:11741158 PMID:15722030 |
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NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294
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G |
FTH1 |
ferritin heavy chain 1 |
increases expression |
ISO |
Stavudine results in increased expression of FTH1 mRNA |
CTD |
PMID:18299183 |
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NCBI chr11:61,964,285...61,967,634
Ensembl chr11:61,959,718...61,967,634
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G |
GAN |
gigaxonin |
decreases expression |
ISO |
Stavudine results in decreased expression of GAN mRNA; Stavudine results in decreased expression of GAN protein |
CTD |
PMID:19398414 |
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NCBI chr16:81,314,962...81,390,809
Ensembl chr16:81,314,944...81,390,809
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G |
GCLC |
glutamate-cysteine ligase catalytic subunit |
increases expression |
ISO |
Stavudine results in increased expression of GCLC mRNA |
CTD |
PMID:18299183 |
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NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
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G |
GPX4 |
glutathione peroxidase 4 |
decreases expression |
ISO |
Stavudine results in decreased expression of GPX4 mRNA |
CTD |
PMID:18299183 |
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NCBI chr19:1,103,994...1,106,779
Ensembl chr19:1,103,982...1,106,791
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G |
GSTA1 |
glutathione S-transferase alpha 1 |
increases expression |
ISO |
Stavudine results in increased expression of GSTA1 mRNA |
CTD |
PMID:18299183 |
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NCBI chr 6:52,791,371...52,803,816
Ensembl chr 6:52,791,371...52,803,860
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G |
GSTP1 |
glutathione S-transferase pi 1 |
increases expression |
ISO |
Stavudine results in increased expression of GSTP1 mRNA |
CTD |
PMID:18299183 |
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NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
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G |
HFE |
homeostatic iron regulator |
multiple interactions |
EXP |
HFE gene SNP affects the susceptibility to [Didanosine co-treated with Stavudine] |
CTD |
PMID:16847405 |
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NCBI chr 6:26,087,429...26,098,343
Ensembl chr 6:26,087,281...26,098,343
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G |
HSPD1 |
heat shock protein family D (Hsp60) member 1 |
affects expression |
EXP |
Stavudine affects the expression of HSPD1 protein |
CTD |
PMID:27041070 |
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NCBI chr 2:197,486,584...197,500,274
Ensembl chr 2:197,486,584...197,516,737
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G |
IGFBP1 |
insulin like growth factor binding protein 1 |
increases expression |
ISO |
Stavudine results in increased expression of IGFBP1 mRNA |
CTD |
PMID:18299183 |
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NCBI chr 7:45,888,488...45,893,660
Ensembl chr 7:45,888,360...45,893,660
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G |
IL1B |
interleukin 1 beta |
increases expression |
EXP |
Stavudine results in increased expression of IL1B protein |
CTD |
PMID:17668557 |
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NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
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G |
IL6 |
interleukin 6 |
increases expression |
EXP |
Stavudine results in increased expression of IL6 protein |
CTD |
PMID:17668557 |
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NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
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G |
JUN |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
Stavudine results in increased expression of JUN mRNA |
CTD |
PMID:18299183 |
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NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
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G |
LEP |
leptin |
decreases expression |
EXP |
Stavudine results in decreased expression of LEP protein |
CTD |
PMID:17668557 |
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NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629
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G |
LONP1 |
lon peptidase 1, mitochondrial |
affects expression |
EXP |
Stavudine affects the expression of LONP1 protein |
CTD |
PMID:27041070 |
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NCBI chr19:5,691,834...5,720,452
Ensembl chr19:5,691,834...5,720,572
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G |
LPL |
lipoprotein lipase |
multiple interactions |
ISO |
[Stavudine co-treated with Lamivudine co-treated with Indinavir] affects the expression of LPL mRNA; [Stavudine co-treated with Lamivudine co-treated with Nelfinavir] results in decreased expression of LPL mRNA; [Stavudine co-treated with Lamivudine] affects the expression of LPL mRNA |
CTD |
PMID:11741158 |
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NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259
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G |
MAPK8 |
mitogen-activated protein kinase 8 |
decreases phosphorylation |
EXP |
Stavudine results in decreased phosphorylation of MAPK8 protein |
CTD |
PMID:27041070 |
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NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360
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G |
ME1 |
malic enzyme 1 |
multiple interactions increases expression |
ISO |
[Stavudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ME1 mRNA; [Stavudine co-treated with Lamivudine co-treated with Nelfinavir] results in decreased expression of ME1 mRNA; [Stavudine co-treated with Lamivudine] results in increased expression of ME1 mRNA Stavudine results in increased expression of ME1 mRNA |
CTD |
PMID:11741158 |
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NCBI chr 6:83,210,402...83,431,051
Ensembl chr 6:83,210,402...83,431,051
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G |
MTTP |
microsomal triglyceride transfer protein |
multiple interactions decreases expression |
ISO |
Carnitine inhibits the reaction [Stavudine results in decreased expression of MTTP mRNA] |
CTD |
PMID:18299183 |
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NCBI chr 4:99,564,130...99,623,997
Ensembl chr 4:99,564,081...99,623,997
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G |
NRF1 |
nuclear respiratory factor 1 |
increases expression |
ISO |
Stavudine results in increased expression of NRF1 mRNA |
CTD |
PMID:17926646 |
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NCBI chr 7:129,611,720...129,757,076
Ensembl chr 7:129,611,720...129,757,082
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G |
PCNA |
proliferating cell nuclear antigen |
increases expression decreases expression |
ISO |
Stavudine results in increased expression of PCNA mRNA Stavudine results in decreased expression of PCNA protein |
CTD |
PMID:18299183 PMID:32278789 |
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NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
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G |
PPARG |
peroxisome proliferator activated receptor gamma |
decreases expression |
EXP ISO |
Stavudine results in decreased expression of PPARG mRNA Stavudine results in decreased expression of PPARG mRNA; Stavudine results in decreased expression of PPARG protein |
CTD |
PMID:14518702 PMID:15722030 PMID:17926646 |
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NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
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G |
PTGS2 |
prostaglandin-endoperoxide synthase 2 |
decreases expression |
ISO |
Stavudine results in decreased expression of PTGS2 protein |
CTD |
PMID:18389896 |
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NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
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G |
SIRT3 |
sirtuin 3 |
increases expression |
EXP |
Stavudine results in increased expression of SIRT3 protein |
CTD |
PMID:27041070 |
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NCBI chr11:215,030...236,931
Ensembl chr11:215,030...236,931
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G |
SLC25A19 |
solute carrier family 25 member 19 |
multiple interactions |
EXP |
SLC25A19 protein affects the susceptibility to [Stavudine co-treated with Lamivudine co-treated with Indinavir] |
CTD |
PMID:15951836 |
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NCBI chr17:75,272,992...75,289,433
Ensembl chr17:75,272,981...75,289,510
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G |
SLC25A5 |
solute carrier family 25 member 5 |
increases expression |
ISO |
Stavudine results in increased expression of SLC25A5 mRNA |
CTD |
PMID:18299183 |
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NCBI chr X:119,468,444...119,471,396
Ensembl chr X:119,468,422...119,471,396
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G |
SLC29A3 |
solute carrier family 29 member 3 |
affects transport |
EXP |
SLC29A3 protein affects the transport of Stavudine |
CTD |
PMID:19164483 |
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NCBI chr10:71,319,259...71,381,423
Ensembl chr10:71,319,259...71,381,423
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G |
SREBF1 |
sterol regulatory element binding transcription factor 1 |
multiple interactions increases expression |
ISO |
Carnitine inhibits the reaction [Stavudine results in increased expression of SREBF1 mRNA] |
CTD |
PMID:18299183 |
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NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002
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G |
STAT3 |
signal transducer and activator of transcription 3 |
decreases expression |
ISO |
Stavudine results in decreased expression of STAT3 mRNA |
CTD |
PMID:18299183 |
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NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568
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G |
TFAP2A |
transcription factor AP-2 alpha |
decreases expression |
ISO |
Stavudine results in decreased expression of TFAP2A mRNA |
CTD |
PMID:17926646 |
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NCBI chr 6:10,396,677...10,419,659
Ensembl chr 6:10,393,186...10,419,659
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G |
TNF |
tumor necrosis factor |
increases expression |
EXP |
Stavudine results in increased expression of TNF protein |
CTD |
PMID:17668557 |
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NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
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G |
TYMP |
thymidine phosphorylase |
increases expression |
EXP |
Stavudine results in increased expression of TYMP protein |
CTD |
PMID:16457948 |
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NCBI chr22:50,525,752...50,530,085
Ensembl chr22:50,525,752...50,530,032
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G |
UCP1 |
uncoupling protein 1 |
decreases expression increases expression |
ISO EXP |
Stavudine results in decreased expression of UCP1 mRNA Stavudine results in increased expression of UCP1 |
CTD |
PMID:16038477 PMID:17926646 |
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NCBI chr 4:140,559,431...140,568,961
Ensembl chr 4:140,559,431...140,568,961
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G |
UCP2 |
uncoupling protein 2 |
decreases expression |
EXP |
Stavudine results in decreased expression of UCP2 mRNA |
CTD |
PMID:14518702 |
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NCBI chr11:73,974,672...73,983,202
Ensembl chr11:73,974,672...73,982,843
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G |
UCP3 |
uncoupling protein 3 |
decreases expression |
EXP |
Stavudine results in decreased expression of UCP3 mRNA |
CTD |
PMID:14518702 |
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NCBI chr11:74,000,277...74,009,085
Ensembl chr11:74,000,277...74,009,085
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