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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1,2-benzoxazoles
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Accession:CHEBI:51545 term browser browse the term
Definition:Compounds based on a fused 1,2-oxazole and benzene bicyclic ring skeleton, with the O atom positioned adjacent to one of the positions of ring fusion.


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iloperidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B member 11 decreases activity ISO iloperidone results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958 		JBrowse link
paliperidone palmitate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A affects abundance
multiple interactions
increases export
increases transport
affects response to substance
decreases activity		 ISO
EXP		 ABCB1 gene polymorphism affects the abundance of Paliperidone Palmitate; ABCB1 protein affects the abundance of Paliperidone Palmitate
Cyclosporine inhibits the reaction [ABCB1A protein results in increased export of Paliperidone Palmitate]
ABCB1A protein results in increased transport of Paliperidone Palmitate
ABCB1A protein affects the susceptibility to Paliperidone Palmitate
Paliperidone Palmitate results in decreased activity of ABCB1 protein
Paliperidone Palmitate inhibits the reaction [ABCB1 protein results in decreased export of Doxorubicin]
ABCB1 protein results in increased transport of Paliperidone Palmitate		 CTD PMID:15502009 PMID:16118767 PMID:16810505 PMID:16936711 PMID:17541883 More... NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B affects response to substance EXP ABCB1B protein affects the susceptibility to Paliperidone Palmitate CTD PMID:15502009 NCBI chr 5:8,848,147...8,916,314
Ensembl chr 5:8,848,147...8,916,315 		JBrowse link
G Abcb4 ATP-binding cassette, sub-family B member 4 decreases activity ISO Paliperidone Palmitate results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) multiple interactions ISO Paliperidone Palmitate inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone] CTD PMID:18834354 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661 		JBrowse link
G Bdnf brain derived neurotrophic factor increases expression ISO Paliperidone Palmitate results in increased expression of BDNF mRNA CTD PMID:21220416 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 increases expression ISO Paliperidone Palmitate results in increased expression of CXCL8 mRNA CTD PMID:32816093 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 affects abundance ISO CYP2D6 gene polymorphism affects the abundance of Paliperidone Palmitate; CYP2D6 protein affects the abundance of Paliperidone Palmitate CTD PMID:10639689 PMID:15089809 PMID:17541883 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
affects binding		 ISO Paliperidone Palmitate binds to and results in decreased activity of DRD2 protein
Paliperidone Palmitate binds to DRD2 protein		 CTD PMID:19713555 PMID:22437487 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477 		JBrowse link
G Fads2 fatty acid desaturase 2 increases expression
multiple interactions		 ISO Paliperidone Palmitate results in increased expression of FADS2 mRNA
[Paliperidone Palmitate results in increased expression of FADS2 mRNA] which results in increased abundance of Fatty Acids, Unsaturated		 CTD PMID:21458237 NCBI chr19:10,040,129...10,078,867
Ensembl chr19:10,040,129...10,079,110 		JBrowse link
G Htr2a 5-hydroxytryptamine (serotonin) receptor 2A affects binding
multiple interactions		 ISO Paliperidone Palmitate binds to HTR2A protein
Paliperidone Palmitate binds to and results in decreased activity of HTR2A protein		 CTD PMID:7520908 PMID:19713555 PMID:22437487 NCBI chr14:74,878,314...74,944,299
Ensembl chr14:74,878,280...74,946,934 		JBrowse link
G Htr7 5-hydroxytryptamine (serotonin) receptor 7 multiple interactions ISO [Paliperidone Palmitate binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; Paliperidone Palmitate binds to and results in decreased activity of HTR7 protein CTD PMID:18996971 PMID:19509219 PMID:20827463 NCBI chr19:35,935,815...36,035,533
Ensembl chr19:35,936,134...36,034,907 		JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Paliperidone Palmitate results in increased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO Paliperidone Palmitate results in increased expression of IL1B mRNA CTD PMID:32816093 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il24 interleukin 24 increases expression ISO Paliperidone Palmitate results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr 1:130,809,801...130,815,153
Ensembl chr 1:130,809,811...130,815,191 		JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity ISO Paliperidone Palmitate results in decreased activity of KCNH2 protein CTD PMID:21394035 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602 		JBrowse link
G Prl prolactin increases expression ISO Paliperidone Palmitate results in increased expression of PRL protein CTD PMID:17460786 PMID:19825908 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188 		JBrowse link
risperidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A increases response to substance
affects abundance
affects response to substance
increases transport
multiple interactions
decreases activity
increases export		 ISO
EXP		 ABCB1 protein results in increased susceptibility to Risperidone
ABCB1 gene polymorphism affects the abundance of Risperidone; ABCB1 protein affects the abundance of Risperidone
ABCB1 gene polymorphism affects the susceptibility to Risperidone; ABCB1 protein affects the susceptibility to Risperidone
ABCB1 protein results in increased transport of Risperidone
Risperidone inhibits the reaction [ABCB1 protein results in decreased export of Doxorubicin]
Risperidone results in decreased activity of ABCB1 protein
ABCB1A protein results in increased transport of Risperidone
ABCB1A protein results in increased export of Risperidone
ABCB1A protein affects the susceptibility to Risperidone
Cyclosporine inhibits the reaction [ABCB1A protein results in increased export of Risperidone]		 CTD PMID:15502009 PMID:16118767 PMID:16810505 PMID:16936711 PMID:17054409 More... NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B affects response to substance EXP ABCB1B protein affects the susceptibility to Risperidone CTD PMID:15502009 NCBI chr 5:8,848,147...8,916,314
Ensembl chr 5:8,848,147...8,916,315 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) multiple interactions ISO Risperidone inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Risperidone inhibits the reaction [ABCG2 protein results in increased uptake of estrone sulfate] CTD PMID:18834354 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions
increases expression		 EXP Berberine inhibits the reaction [Risperidone results in increased expression of ADIPOQ mRNA] CTD PMID:20564506 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Bdnf brain derived neurotrophic factor decreases expression
multiple interactions		 ISO Risperidone results in decreased expression of BDNF mRNA
Risperidone inhibits the reaction [Rotenone results in decreased expression of BDNF mRNA]
BDNF gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein]		 CTD PMID:12393228 PMID:17442543 PMID:19997080 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Calm2 calmodulin 2 increases expression ISO Risperidone results in increased expression of CALM2 mRNA CTD PMID:19289156 NCBI chr17:87,740,829...87,754,363
Ensembl chr17:87,740,840...87,754,363 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha decreases expression ISO Risperidone results in decreased expression of CAMK2A protein CTD PMID:19289156 NCBI chr18:61,058,704...61,121,224
Ensembl chr18:61,058,690...61,121,224 		JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV decreases expression ISO Risperidone results in decreased expression of CAMK4 protein CTD PMID:19289156 NCBI chr18:33,067,995...33,328,820
Ensembl chr18:33,067,984...33,324,281 		JBrowse link
G Camkk1 calcium/calmodulin-dependent protein kinase kinase 1, alpha decreases expression ISO Risperidone results in decreased expression of CAMKK1 protein CTD PMID:19289156 NCBI chr11:72,906,869...72,932,899
Ensembl chr11:72,909,834...72,932,899 		JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2, beta decreases expression ISO Risperidone results in decreased expression of CAMKK2 protein CTD PMID:19289156 NCBI chr 5:122,856,064...122,918,295
Ensembl chr 5:122,869,233...122,917,472 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO Palmitic Acid promotes the reaction [Risperidone results in increased activity of CASP3 protein] CTD PMID:22700542 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity		 ISO Palmitic Acid promotes the reaction [Risperidone results in increased activity of CASP7 protein] CTD PMID:22700542 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions
increases expression		 EXP Berberine inhibits the reaction [Risperidone results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of CEBPA protein]
Risperidone results in increased expression of CEBPA mRNA; Risperidone results in increased expression of CEBPA protein		 CTD PMID:20564506 NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353 		JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 affects response to substance EXP CHRM4 affects the susceptibility to Risperidone CTD PMID:21269601 NCBI chr 2:91,752,531...91,760,180
Ensembl chr 2:91,757,594...91,759,033 		JBrowse link
G Comt catechol-O-methyltransferase increases expression ISO Risperidone results in increased expression of COMT mRNA CTD PMID:15964593 NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602 		JBrowse link
G Crh corticotropin releasing hormone decreases expression ISO Risperidone results in decreased expression of CRH mRNA CTD PMID:16205782 NCBI chr 3:19,747,565...19,749,560
Ensembl chr 3:19,747,565...19,749,560 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases expression		 ISO DRD2 protein affects the reaction [Risperidone results in increased expression of CTNNB1 protein] CTD PMID:16144542 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573 		JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 affects response to substance
decreases hydroxylation
decreases metabolic processing
affects abundance
multiple interactions
affects metabolic processing
increases metabolic processing
increases response to substance		 ISO CYP2D6 gene polymorphism affects the susceptibility to Risperidone; CYP2D6 protein polymorphism affects the susceptibility to Risperidone
CYP2D6 gene polymorphism results in decreased hydroxylation of Risperidone
CYP2D6 gene polymorphism results in decreased metabolism of Risperidone
CYP2D6 gene polymorphism affects the abundance of Risperidone; CYP2D6 protein affects the abundance of Risperidone
CYP2D6 gene polymorphism affects the metabolism of and affects the abundance of Risperidone; CYP2D6 protein affects the metabolism of and affects the abundance of Risperidone
CYP2D6 gene polymorphism affects the metabolism of Risperidone; CYP2D6 protein affects the metabolism of Risperidone
CYP2D6 protein results in increased metabolism of Risperidone
CYP2D6 protein results in increased susceptibility to Risperidone		 CTD PMID:10639689 PMID:15089809 PMID:15260906 PMID:15565299 PMID:15669884 More... NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461 		JBrowse link
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 affects abundance
increases metabolic processing		 ISO CYP3A5 gene polymorphism affects the abundance of Risperidone; CYP3A5 protein affects the abundance of Risperidone
CYP3A5 protein results in increased metabolism of Risperidone		 CTD PMID:18708991 PMID:20332423 NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
affects response to substance
increases response to substance
affects binding		 ISO Risperidone binds to and results in decreased activity of DRD2 protein
DRD2 gene polymorphism affects the susceptibility to Risperidone
DRD2 gene polymorphism results in increased susceptibility to Risperidone; DRD2 gene SNP results in increased susceptibility to Risperidone; DRD2 protein results in increased susceptibility to Risperidone
Risperidone binds to DRD2 protein
[Risperidone binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein; DRD2 protein affects the reaction [Risperidone results in increased expression of CTNNB1 protein]; DRD2 protein affects the reaction [Risperidone results in increased expression of DVL3 protein]; DRD2 protein affects the reaction [Risperidone results in increased expression of GSK3A protein]; DRD2 protein affects the reaction [Risperidone results in increased expression of GSK3B protein]; Risperidone binds to and results in decreased activity of DRD2 protein; Risperidone inhibits the reaction [Apomorphine binds to and results in increased activity of DRD2 protein]; Risperidone promotes the reaction [Dopamine binds to DRD2 protein]		 CTD PMID:1380082 PMID:7520908 PMID:8804920 PMID:10831489 PMID:12191584 More... NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477 		JBrowse link
G Drd3 dopamine receptor D3 increases response to substance ISO DRD3 gene SNP results in increased susceptibility to Risperidone; DRD3 protein results in increased susceptibility to Risperidone CTD PMID:19506579 PMID:19997080 NCBI chr16:43,574,285...43,646,353
Ensembl chr16:43,574,389...43,643,295 		JBrowse link
G Dvl3 dishevelled segment polarity protein 3 multiple interactions
increases expression		 ISO DRD2 protein affects the reaction [Risperidone results in increased expression of DVL3 protein] CTD PMID:16144542 NCBI chr16:20,335,694...20,352,763
Ensembl chr16:20,335,732...20,352,760 		JBrowse link
G Egr1 early growth response 1 decreases expression ISO Risperidone results in decreased expression of EGR1 protein CTD PMID:17028028 NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037 		JBrowse link
G Egr2 early growth response 2 decreases expression
multiple interactions		 ISO
EXP		 Risperidone results in decreased expression of EGR2 protein
Risperidone inhibits the reaction [Toluene promotes the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of EGR2 protein]]		 CTD PMID:17028028 PMID:32980479 NCBI chr10:67,370,334...67,383,354
Ensembl chr10:67,371,305...67,378,018 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 increases phosphorylation ISO Risperidone results in increased phosphorylation of ERBB2 protein CTD PMID:26961615 NCBI chr11:98,303,310...98,328,542
Ensembl chr11:98,303,296...98,328,542 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 multiple interactions ISO Risperidone results in increased expression of and results in increased phosphorylation of ERBB4 protein CTD PMID:26961615 NCBI chr 1:68,071,063...69,147,756
Ensembl chr 1:68,071,345...69,147,218 		JBrowse link
G Fads2 fatty acid desaturase 2 increases expression
multiple interactions		 ISO Risperidone results in increased expression of FADS2 mRNA
[Risperidone results in increased expression of FADS2 mRNA] which results in increased abundance of Fatty Acids, Unsaturated		 CTD PMID:21458237 NCBI chr19:10,040,129...10,078,867
Ensembl chr19:10,040,129...10,079,110 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression		 EXP Berberine inhibits the reaction [Risperidone results in increased expression of FAS mRNA] CTD PMID:20564506 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions
increases expression		 ISO
EXP		 Risperidone promotes the reaction [Rotenone results in increased expression of FOS mRNA]
Risperidone results in increased expression of FOS mRNA
Dronabinol inhibits the reaction [Risperidone results in increased expression of FOS protein]; Risperidone inhibits the reaction [Toluene promotes the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of FOS protein]]		 CTD PMID:11516571 PMID:17442543 PMID:28272498 PMID:32980479 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Fshb follicle stimulating hormone beta affects expression ISO Risperidone affects the expression of FSHB protein CTD PMID:18838228 NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions ISO Acetylcysteine inhibits the reaction [Risperidone results in increased expression of and results in increased secretion of GGT1 protein]; coenzyme Q10 inhibits the reaction [Risperidone results in increased expression of and results in increased secretion of GGT1 protein]; Risperidone results in increased expression of and results in increased secretion of GGT1 protein CTD PMID:27387968 NCBI chr10:75,396,910...75,422,027
Ensembl chr10:75,397,438...75,422,034 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1, soluble multiple interactions ISO Acetylcysteine inhibits the reaction [Risperidone results in increased expression of and results in increased secretion of GOT1 protein]; coenzyme Q10 inhibits the reaction [Risperidone results in increased expression of and results in increased secretion of GOT1 protein]; Risperidone results in increased expression of and results in increased secretion of GOT1 protein CTD PMID:27387968 NCBI chr19:43,488,191...43,514,743
Ensembl chr19:43,488,191...43,513,044 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions ISO Acetylcysteine inhibits the reaction [Risperidone results in increased expression of and results in increased secretion of GPT protein]; coenzyme Q10 inhibits the reaction [Risperidone results in increased expression of and results in increased secretion of GPT protein]; Risperidone results in increased expression of and results in increased secretion of GPT protein CTD PMID:27387968 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha increases expression
multiple interactions		 ISO Risperidone results in increased expression of GSK3A protein
DRD2 protein affects the reaction [Risperidone results in increased expression of GSK3A protein]		 CTD PMID:16144542 NCBI chr 7:24,927,683...24,937,276
Ensembl chr 7:24,927,683...24,937,276 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases expression		 ISO DRD2 protein affects the reaction [Risperidone results in increased expression of GSK3B protein] CTD PMID:16144542 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase increases expression ISO Risperidone results in increased expression of HMGCR mRNA CTD PMID:17052361 NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444 		JBrowse link
G Homer1 homer scaffolding protein 1 increases expression ISO Risperidone results in increased expression of HOMER1 mRNA CTD PMID:20147574 NCBI chr13:93,440,265...93,549,471
Ensembl chr13:93,436,143...93,541,637 		JBrowse link
G Htr1a 5-hydroxytryptamine (serotonin) receptor 1A increases response to substance
multiple interactions		 ISO HTR1A protein results in increased susceptibility to Risperidone
N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [HTR1A protein results in increased susceptibility to Risperidone]		 CTD PMID:17530476 NCBI chr13:105,580,040...105,584,630
Ensembl chr13:105,580,147...105,584,630 		JBrowse link
G Htr2a 5-hydroxytryptamine (serotonin) receptor 2A increases response to substance
affects response to substance
multiple interactions
affects binding		 ISO HTR2A gene SNP results in increased susceptibility to Risperidone; HTR2A protein results in increased susceptibility to Risperidone
HTR2A protein affects the susceptibility to Risperidone
HTR2A gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein]; Risperidone binds to and results in decreased activity of HTR2A protein
Risperidone binds to and results in decreased activity of HTR2A protein; Risperidone inhibits the reaction [Ketanserin binds to HTR2A protein]
Risperidone binds to HTR2A protein		 CTD PMID:7520908 PMID:11927170 PMID:12191584 PMID:16314884 PMID:16948927 More... NCBI chr14:74,878,314...74,944,299
Ensembl chr14:74,878,280...74,946,934 		JBrowse link
G Htr2c 5-hydroxytryptamine (serotonin) receptor 2C affects response to substance
increases response to substance
multiple interactions		 ISO HTR2C gene polymorphism affects the susceptibility to Risperidone; HTR2C protein affects the susceptibility to Risperidone
HTR2C protein results in increased susceptibility to Risperidone
HTR2C gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein]		 CTD PMID:19142101 PMID:19997080 NCBI chr  X:145,745,509...145,980,273
Ensembl chr  X:145,745,509...145,980,273 		JBrowse link
G Htr6 5-hydroxytryptamine (serotonin) receptor 6 multiple interactions ISO HTR6 gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein] CTD PMID:19997080 NCBI chr 4:138,787,017...138,802,881
Ensembl chr 4:138,788,419...138,802,881 		JBrowse link
G Htr7 5-hydroxytryptamine (serotonin) receptor 7 multiple interactions ISO 2-((2-(dimethylamino)ethyl)thio)-3-phenylquinoline inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]; [Risperidone binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; Clozapine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]; Cyproheptadine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]; mesulergine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]; Mianserin inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]; Risperidone binds to and results in decreased activity of HTR7 protein; SB 269970 inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein] CTD PMID:18996971 PMID:19509219 PMID:20827463 NCBI chr19:35,935,815...36,035,533
Ensembl chr19:35,936,134...36,034,907 		JBrowse link
G Inha inhibin alpha multiple interactions ISO Risperidone results in increased expression of [INHA protein binds to INHBB protein] CTD PMID:18838228 NCBI chr 1:75,483,872...75,487,010
Ensembl chr 1:75,483,721...75,487,010 		JBrowse link
G Inhbb inhibin beta-B multiple interactions ISO Risperidone results in increased expression of [INHA protein binds to INHBB protein] CTD PMID:18838228 NCBI chr 1:119,343,193...119,349,978
Ensembl chr 1:119,343,195...119,349,978 		JBrowse link
G Ins2 insulin II increases expression ISO Risperidone results in increased expression of INS protein CTD PMID:11927762 PMID:16601995 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118 		JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 multiple interactions ISO Risperidone inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602 		JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions
increases expression		 EXP Berberine inhibits the reaction [Risperidone results in increased expression of LDLR mRNA] CTD PMID:20564506 NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215 		JBrowse link
G Maoa monoamine oxidase A affects response to substance
increases response to substance		 ISO MAOA gene polymorphism affects the susceptibility to Risperidone
MAOA protein results in increased susceptibility to Risperidone		 CTD PMID:22544010 NCBI chr  X:16,485,937...16,554,051
Ensembl chr  X:16,485,937...16,554,057 		JBrowse link
G Maob monoamine oxidase B increases expression ISO Risperidone results in increased expression of MAOB mRNA CTD PMID:15964593 NCBI chr  X:16,575,520...16,683,605
Ensembl chr  X:16,575,521...16,683,605 		JBrowse link
G Map2 microtubule-associated protein 2 increases expression ISO Risperidone results in increased expression of MAP2 mRNA CTD PMID:15079866 NCBI chr 1:66,214,337...66,481,742
Ensembl chr 1:66,214,432...66,481,742 		JBrowse link
G Ngfr nerve growth factor receptor (TNFR superfamily, member 16) decreases expression ISO Risperidone results in decreased expression of NGFR mRNA CTD PMID:12111809 PMID:16513140 NCBI chr11:95,459,644...95,478,524
Ensembl chr11:95,459,644...95,478,561 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Risperidone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Risperidone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA] CTD PMID:21402137 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186 		JBrowse link
G Nrg1 neuregulin 1 increases expression ISO Risperidone results in increased expression of NRG1 protein CTD PMID:26961615 NCBI chr 8:32,299,493...33,381,858
Ensembl chr 8:32,304,579...33,374,825
Ensembl chr 8:32,304,579...33,374,825 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma increases expression
multiple interactions		 EXP Risperidone results in increased expression of PPARG mRNA; Risperidone results in increased expression of PPARG protein
Berberine inhibits the reaction [Risperidone results in increased expression of PPARG mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of PPARG protein]		 CTD PMID:20564506 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ppp3ca protein phosphatase 3, catalytic subunit, alpha isoform multiple interactions
decreases expression		 ISO [Risperidone binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein
Risperidone results in decreased expression of PPP3CA mRNA; Risperidone results in decreased expression of PPP3CA protein		 CTD PMID:16033416 NCBI chr 3:136,375,778...136,643,488
Ensembl chr 3:136,375,885...136,643,488 		JBrowse link
G Prl prolactin multiple interactions
increases secretion
increases expression		 ISO [Risperidone co-treated with Clozapine] results in increased expression of PRL protein; Aripiprazole inhibits the reaction [Risperidone results in increased secretion of PRL protein]; BDNF gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein]; HTR2A gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein]; HTR2C gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein]; HTR6 gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein]
Risperidone inhibits the reaction [Dopamine results in decreased secretion of PRL protein]		 CTD PMID:1380082 PMID:9696519 PMID:9989566 PMID:10084644 PMID:11048906 More... NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 increases expression ISO Risperidone results in increased expression of RGS2 mRNA CTD PMID:11516571 NCBI chr 1:143,875,076...143,879,887
Ensembl chr 1:143,875,076...143,879,899 		JBrowse link
G S100b S100 protein, beta polypeptide, neural increases secretion ISO Risperidone results in increased secretion of S100B protein CTD PMID:18421423 NCBI chr10:76,089,670...76,097,153
Ensembl chr10:76,089,687...76,096,993 		JBrowse link
G Slc17a6 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6 increases expression EXP Risperidone results in increased expression of SLC17A6 mRNA; Risperidone results in increased expression of SLC17A6 protein CTD PMID:18155072 NCBI chr 7:51,271,578...51,320,874
Ensembl chr 7:51,271,754...51,320,867 		JBrowse link
G Snap25 synaptosomal-associated protein 25 affects response to substance ISO SNAP25 gene SNP affects the susceptibility to Risperidone CTD PMID:15823421 NCBI chr 2:136,555,359...136,624,348
Ensembl chr 2:136,555,373...136,624,348 		JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions
increases expression		 ISO Risperidone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SOD1 mRNA]; Risperidone inhibits the reaction [Haloperidol results in decreased expression of SOD1 protein]
Risperidone results in increased expression of SOD1 mRNA		 CTD PMID:12111809 PMID:12752374 PMID:16564057 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
increases expression		 EXP Berberine inhibits the reaction [Risperidone results in increased expression of SREBF1 mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of SREBF1 protein]
Risperidone results in increased expression of SREBF1 mRNA; Risperidone results in increased expression of SREBF1 protein		 CTD PMID:20564506 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Risperidone inhibits the reaction [Rotenone results in decreased expression of STAT3 mRNA] CTD PMID:17442543 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366 		JBrowse link
G Th tyrosine hydroxylase increases expression ISO Risperidone results in increased expression of TH protein CTD PMID:17028028 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865 		JBrowse link
zonisamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Car1 carbonic anhydrase 1 multiple interactions ISO zonisamide binds to and results in decreased activity of CA1 protein CTD PMID:17826101 NCBI chr 3:14,831,274...14,873,425
Ensembl chr 3:14,831,276...14,873,428 		JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO zonisamide binds to and results in decreased activity of CA2 protein CTD PMID:17826101 NCBI chr 3:14,951,329...14,965,830
Ensembl chr 3:14,951,333...14,965,830 		JBrowse link
G Car3 carbonic anhydrase 3 multiple interactions ISO zonisamide binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 3:14,928,598...14,937,441
Ensembl chr 3:14,928,572...14,937,583 		JBrowse link
G Drd1 dopamine receptor D1 multiple interactions ISO DRD1 protein promotes the reaction [zonisamide affects the secretion of Dopamine]; DRD1 protein promotes the reaction [zonisamide affects the secretion of gamma-Aminobutyric Acid] CTD PMID:19482038 NCBI chr13:54,205,202...54,209,677
Ensembl chr13:54,205,202...54,209,724 		JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions ISO zonisamide inhibits the reaction [Tacrine results in increased expression of FOS protein] CTD PMID:18693129 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP zonisamide inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GFAP protein] CTD PMID:19199078 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738 		JBrowse link
G Ifng interferon gamma decreases expression EXP zonisamide results in decreased expression of IFNG protein CTD PMID:10982153 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Maob monoamine oxidase B multiple interactions
decreases activity		 EXP zonisamide inhibits the reaction [[MAOB protein results in increased metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] which results in increased chemical synthesis of 1-Methyl-4-phenylpyridinium]; zonisamide inhibits the reaction [Selegiline binds to MAOB protein]
zonisamide results in decreased activity of MAOB protein		 CTD PMID:19948168 NCBI chr  X:16,575,520...16,683,605
Ensembl chr  X:16,575,521...16,683,605 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible increases expression ISO zonisamide results in increased expression of NOS2 mRNA CTD PMID:12429386 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Slc1a1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 increases expression ISO zonisamide results in increased expression of SLC1A1 protein CTD PMID:12941455 NCBI chr19:28,812,535...28,891,360
Ensembl chr19:28,812,449...28,891,360 		JBrowse link
G Th tyrosine hydroxylase increases expression
multiple interactions		 ISO
EXP		 zonisamide results in increased expression of TH mRNA; zonisamide results in increased expression of TH protein
[zonisamide co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] affects the activity of TH protein; zonisamide inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]		 CTD PMID:19199078 PMID:19948168 PMID:20196486 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    chemical entity 22208
      atom 22170
        nonmetal atom 22055
          nitrogen atom 20030
            nitrogen molecular entity 20004
              organonitrogen compound 19809
                organonitrogen heterocyclic compound 19099
                  benzoxazole 121
                    benzisoxazole 78
                      1,2-benzoxazoles 78
                        1,2-benzoxazole 0
                        1-(3-amino-1,2-benzoxazol-5-yl)-6-(2'-\{[(3R)-3-hydroxypyrrolidin-1-yl]methyl\}biphenyl-4-yl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one 0
                        3-\{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl\}-2-methyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-9-yl hexadecanoate + 16
                        3-\{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl\}-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one + 0
                        4-chloro-6-\{5-[(2-morpholin-4-ylethyl)amino]-1,2-benzisoxazol-3-yl\}benzene-1,3-diol 0
                        4-methyl-N-[3-(morpholin-4-yl)phenyl]-3-[3-(piperidin-4-yl)-1,2-benzoxazol-6-yl]benzamide 0
                        iloperidone 1
                        risperidone 64
                        zonisamide 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            organic molecule 21647
                              organic cyclic compound 21252
                                organic heterocyclic compound 20352
                                  organic heteropolycyclic compound 19645
                                    organic heterobicyclic compound 18203
                                      benzoxazole 121
                                        benzisoxazole 78
                                          1,2-benzoxazoles 78
                                            1,2-benzoxazole 0
                                            1-(3-amino-1,2-benzoxazol-5-yl)-6-(2'-\{[(3R)-3-hydroxypyrrolidin-1-yl]methyl\}biphenyl-4-yl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one 0
                                            3-\{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl\}-2-methyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-9-yl hexadecanoate + 16
                                            3-\{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl\}-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one + 0
                                            4-chloro-6-\{5-[(2-morpholin-4-ylethyl)amino]-1,2-benzisoxazol-3-yl\}benzene-1,3-diol 0
                                            4-methyl-N-[3-(morpholin-4-yl)phenyl]-3-[3-(piperidin-4-yl)-1,2-benzoxazol-6-yl]benzamide 0
                                            iloperidone 1
                                            risperidone 64
                                            zonisamide 11
paths to the root