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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:endothelin receptor antagonist
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Accession:CHEBI:51451 term browser browse the term
Definition:A hormone antagonist that blocks endothelin receptors.
Synonyms:related_synonym: ERA


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bosentan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AA467197 expressed sequence AA467197 affects expression ISO Bosentan affects the expression of C15ORF48 mRNA CTD PMID:29761207 NCBI chr 2:122,637,887...122,641,076
Ensembl chr 2:122,636,986...122,641,191
JBrowse link
G Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 decreases activity
decreases expression
multiple interactions
ISO bosentan metabolite results in decreased activity of ABCB11 protein; bosentan results in decreased activity of ABCB11 protein
Bosentan results in decreased expression of ABCB11 mRNA
bosentan results in decreased expression of ABCB11 mRNA
bosentan inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:11309550 PMID:15465654 PMID:15509663 PMID:20829430 PMID:23956101 PMID:24014644 PMID:27765674 PMID:29761207 NCBI chr 2:69,238,282...69,342,616
Ensembl chr 2:69,238,282...69,342,616
JBrowse link
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A decreases expression ISO bosentan results in decreased expression of ABCB1 mRNA CTD PMID:28369585 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Abcb4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 decreases expression ISO Bosentan results in decreased expression of ABCB4 mRNA CTD PMID:29761207 NCBI chr 5:8,893,614...8,959,226
Ensembl chr 5:8,893,717...8,959,231
JBrowse link
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 increases expression
decreases expression
ISO bosentan results in increased expression of ABCC2 mRNA
Bosentan results in increased expression of ABCC2 mRNA
bosentan results in decreased expression of ABCC2 mRNA
CTD PMID:27765674 PMID:28369585 PMID:29761207 NCBI chr19:43,782,308...43,838,332
Ensembl chr19:43,782,192...43,840,740
JBrowse link
G Abcc3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 increases expression
decreases expression
ISO bosentan results in increased expression of ABCC3 mRNA
bosentan results in decreased expression of ABCC3 mRNA
CTD PMID:27765674 PMID:28369585 NCBI chr11:94,343,295...94,393,017
Ensembl chr11:94,343,295...94,392,997
JBrowse link
G Abcc4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 increases expression ISO bosentan results in increased expression of ABCC4 mRNA CTD PMID:27765674 NCBI chr14:118,482,692...118,707,856
Ensembl chr14:118,482,692...118,706,219
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression
affects expression
ISO bosentan results in increased expression of ABCG5 mRNA
Bosentan affects the expression of ABCG5 mRNA
CTD PMID:27765674 PMID:29761207 NCBI chr17:84,658,174...84,683,011
Ensembl chr17:84,658,234...84,683,011
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 increases expression ISO bosentan results in increased expression of ABCG8 mRNA CTD PMID:27765674 NCBI chr17:84,676,302...84,700,333
Ensembl chr17:84,676,302...84,700,333
JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) decreases expression ISO Bosentan results in decreased expression of ADH1C mRNA; Bosentan results in decreased expression of ADH1C protein CTD PMID:29761207 NCBI chr 3:138,277,585...138,290,698
Ensembl chr 3:138,260,991...138,290,698
JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide decreases expression ISO Bosentan results in decreased expression of ADH4 mRNA; Bosentan results in decreased expression of ADH4 protein CTD PMID:29761207 NCBI chr 3:138,415,456...138,432,683
Ensembl chr 3:138,415,466...138,430,892
JBrowse link
G Adrb2 adrenergic receptor, beta 2 multiple interactions ISO bosentan inhibits the reaction [EDN1 protein results in increased expression of ADRB2 mRNA] CTD PMID:22483689 NCBI chr18:62,177,713...62,179,981
Ensembl chr18:62,177,816...62,179,959
JBrowse link
G Aldh8a1 aldehyde dehydrogenase 8 family, member A1 affects expression ISO Bosentan affects the expression of ALDH8A1 mRNA CTD PMID:29761207 NCBI chr10:21,377,300...21,396,578
Ensembl chr10:21,377,291...21,396,585
JBrowse link
G Aldob aldolase B, fructose-bisphosphate decreases expression ISO Bosentan results in decreased expression of ALDOB mRNA; Bosentan results in decreased expression of ALDOB protein CTD PMID:29761207 NCBI chr 4:49,535,993...49,549,546
Ensembl chr 4:49,535,995...49,549,546
JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 affects expression ISO Bosentan affects the expression of ASCL1 mRNA CTD PMID:29761207 NCBI chr10:87,490,819...87,493,660
Ensembl chr10:87,490,819...87,493,660
JBrowse link
G Bax BCL2-associated X protein multiple interactions EXP bosentan inhibits the reaction [Doxorubicin results in increased expression of BAX protein] CTD PMID:17974986 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G C9 complement component 9 affects expression ISO Bosentan affects the expression of C9 mRNA CTD PMID:29761207 NCBI chr15:6,445,346...6,498,825
Ensembl chr15:6,445,327...6,498,751
JBrowse link
G Car12 carbonic anhydrase 12 affects expression ISO Bosentan affects the expression of CA12 mRNA CTD PMID:29761207 NCBI chr 9:66,712,296...66,766,845
Ensembl chr 9:66,713,686...66,766,845
JBrowse link
G Cat catalase decreases expression ISO Bosentan results in decreased expression of CAT mRNA CTD PMID:29761207 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Cfhr2 complement factor H-related 2 affects expression ISO Bosentan affects the expression of CFHR3 mRNA CTD PMID:29761207 NCBI chr 1:139,810,292...139,858,699
Ensembl chr 1:139,804,167...139,858,718
Ensembl chr 1:139,804,167...139,858,718
JBrowse link
G Col1a2 collagen, type I, alpha 2 decreases expression EXP bosentan results in decreased expression of COL1A2 protein CTD PMID:11729239 NCBI chr 6:4,505,618...4,541,543
Ensembl chr 6:4,504,814...4,541,544
JBrowse link
G Cps1 carbamoyl-phosphate synthetase 1 decreases expression ISO Bosentan results in decreased expression of CPS1 mRNA; Bosentan results in decreased expression of CPS1 protein CTD PMID:29761207 NCBI chr 1:67,122,426...67,231,267
Ensembl chr 1:67,123,026...67,231,259
JBrowse link
G Cxadr coxsackie virus and adenovirus receptor decreases expression
multiple interactions
ISO bosentan results in decreased expression of CXADR mRNA; bosentan results in decreased expression of CXADR protein
EDN1 protein inhibits the reaction [bosentan results in decreased expression of CXADR mRNA]
CTD PMID:20392896 NCBI chr16:78,301,226...78,359,785
Ensembl chr16:78,301,489...78,359,774
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 increases expression ISO Bosentan results in increased expression of CXCL8 mRNA CTD PMID:29761207 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 increases expression ISO Bosentan results in increased expression of CYP2B6 mRNA CTD PMID:18332078 PMID:29761207 NCBI chr 7:25,897,658...25,926,624
Ensembl chr 7:25,897,620...25,926,624
JBrowse link
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 affects expression ISO Bosentan affects the expression of CYP3A7 mRNA CTD PMID:29761207 NCBI chr 5:137,892,933...137,925,610
Ensembl chr 5:137,892,932...137,921,619
JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 decreases expression ISO Bosentan results in decreased expression of CYP7A1 mRNA CTD PMID:29761207 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633
JBrowse link
G Dclk1 doublecortin-like kinase 1 affects expression ISO Bosentan affects the expression of DCLK1 mRNA CTD PMID:29761207 NCBI chr 3:55,242,303...55,539,068
Ensembl chr 3:55,242,364...55,539,068
JBrowse link
G Dlx6 distal-less homeobox 6 decreases expression EXP bosentan results in decreased expression of DLX6 mRNA CTD PMID:15063187 NCBI chr 6:6,863,334...6,867,970
Ensembl chr 6:6,863,334...6,868,568
JBrowse link
G Edn1 endothelin 1 multiple interactions
decreases activity
decreases expression
ISO bosentan inhibits the reaction [EDN1 protein results in increased expression of ADRB2 mRNA]; bosentan inhibits the reaction [Oxotremorine results in increased activity of EDN1 protein]; bosentan inhibits the reaction [TGFB1 protein results in increased activity of EDN1 protein]; EDN1 protein inhibits the reaction [bosentan results in decreased expression of CXADR mRNA]
bosentan results in decreased activity of EDN1 protein
bosentan results in decreased expression of EDN1 protein
3,5-dibromosalicylic acid inhibits the reaction [bosentan inhibits the reaction [EDN1 protein binds to EDNRA protein]]; bosentan binds to and results in decreased activity of EDN1 protein; bosentan inhibits the reaction [EDN1 protein binds to EDNRA protein]; bosentan inhibits the reaction [Monocrotaline results in increased expression of EDN1 mRNA]
CTD PMID:10474778 PMID:10961375 PMID:11093786 PMID:16431896 PMID:20392896 PMID:20967148 PMID:22483689 PMID:22796455 NCBI chr13:42,301,476...42,307,990
Ensembl chr13:42,301,476...42,307,990
JBrowse link
G Edn3 endothelin 3 decreases activity ISO bosentan results in decreased activity of EDN3 protein CTD PMID:10961375 NCBI chr 2:174,760,619...174,784,042
Ensembl chr 2:174,760,619...174,784,042
JBrowse link
G Ednra endothelin receptor type A multiple interactions ISO bosentan binds to and results in decreased activity of EDNRA protein
3,5-dibromosalicylic acid inhibits the reaction [Bosentan inhibits the reaction [EDN1 protein binds to EDNRA protein]]; Bosentan binds to and results in decreased activity of EDNRA protein; Bosentan inhibits the reaction [EDN1 protein binds to EDNRA protein]
CTD PMID:11093786 PMID:15964565 PMID:16219361 NCBI chr 8:77,663,029...77,724,452
Ensembl chr 8:77,663,031...77,724,464
JBrowse link
G Ednrb endothelin receptor type B multiple interactions ISO bosentan binds to and results in decreased activity of EDNRB protein CTD PMID:16219361 NCBI chr14:103,814,615...103,844,508
Ensembl chr14:103,814,625...103,844,402
JBrowse link
G Fabp1 fatty acid binding protein 1, liver decreases expression ISO Bosentan results in decreased expression of FABP1 mRNA; Bosentan results in decreased expression of FABP1 protein CTD PMID:29761207 NCBI chr 6:71,199,879...71,205,034
Ensembl chr 6:71,199,827...71,205,023
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO bosentan inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; bosentan inhibits the reaction [Glucose results in increased expression of FN1 protein] CTD PMID:12388107 NCBI chr 1:71,585,473...71,653,280
Ensembl chr 1:71,585,520...71,653,200
JBrowse link
G G0s2 G0/G1 switch gene 2 affects expression ISO Bosentan affects the expression of G0S2 mRNA CTD PMID:29761207 NCBI chr 1:193,272,160...193,273,188
Ensembl chr 1:193,272,161...193,273,217
JBrowse link
G G6pc glucose-6-phosphatase, catalytic affects expression ISO Bosentan affects the expression of G6PC1 mRNA CTD PMID:29761207 NCBI chr11:101,367,716...101,377,903
Ensembl chr11:101,367,561...101,377,903
JBrowse link
G Gata4 GATA binding protein 4 multiple interactions
affects activity
EXP
ISO
bosentan inhibits the reaction [Doxorubicin results in decreased expression of GATA4 mRNA]; bosentan inhibits the reaction [Doxorubicin results in decreased expression of GATA4 protein]
bosentan affects the activity of GATA4 protein
CTD PMID:17974986 PMID:21084678 NCBI chr14:63,198,914...63,271,712
Ensembl chr14:63,198,922...63,271,692
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Bosentan results in increased expression of GCLC mRNA CTD PMID:29761207 NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression ISO Bosentan results in decreased expression of GPX1 mRNA CTD PMID:29761207 NCBI chr 9:108,339,080...108,340,342
Ensembl chr 9:108,338,903...108,340,343
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Bosentan results in increased expression of HMOX1 mRNA CTD PMID:29761207 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hnf4a hepatic nuclear factor 4, alpha decreases expression ISO Bosentan results in decreased expression of HNF4A mRNA CTD PMID:29761207 NCBI chr 2:163,506,811...163,572,907
Ensembl chr 2:163,506,808...163,572,910
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 affects expression ISO Bosentan affects the expression of HSD3B1 mRNA CTD PMID:29761207 NCBI chr 3:98,842,356...98,859,794
Ensembl chr 3:98,852,194...98,859,794
JBrowse link
G Igf1 insulin-like growth factor 1 affects expression ISO Bosentan affects the expression of IGF1 mRNA CTD PMID:29761207 NCBI chr10:87,858,265...87,937,047
Ensembl chr10:87,858,265...87,937,042
JBrowse link
G Il6 interleukin 6 increases expression ISO Bosentan results in increased expression of IL6 mRNA CTD PMID:29761207 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Inhbe inhibin beta-E affects expression ISO Bosentan affects the expression of INHBE mRNA CTD PMID:29761207 NCBI chr10:127,349,402...127,351,848
Ensembl chr10:127,348,857...127,354,411
JBrowse link
G Kmo kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) affects expression ISO Bosentan affects the expression of KMO mRNA CTD PMID:29761207 NCBI chr 1:175,632,193...175,660,853
Ensembl chr 1:175,620,381...175,662,116
JBrowse link
G Leap2 liver-expressed antimicrobial peptide 2 affects expression ISO Bosentan affects the expression of LEAP2 mRNA CTD PMID:29761207 NCBI chr11:53,422,181...53,423,136
Ensembl chr11:53,422,181...53,423,170
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 decreases expression ISO Bosentan results in decreased expression of MGST1 mRNA CTD PMID:29761207 NCBI chr 6:138,140,527...138,156,755
Ensembl chr 6:138,140,316...138,156,755
JBrowse link
G Mrc1 mannose receptor, C type 1 affects expression ISO Bosentan affects the expression of MRC1 mRNA CTD PMID:29761207 NCBI chr 2:14,229,414...14,332,023
Ensembl chr 2:14,229,392...14,332,057
JBrowse link
G Mt1 metallothionein 1 increases expression ISO Bosentan results in increased expression of MT1X mRNA CTD PMID:29761207 NCBI chr 8:94,178,883...94,180,327
Ensembl chr 8:94,179,082...94,180,327
JBrowse link
G Mttp microsomal triglyceride transfer protein decreases expression ISO Bosentan results in decreased expression of MTTP mRNA CTD PMID:29761207 NCBI chr 3:138,089,855...138,143,418
Ensembl chr 3:138,089,854...138,144,968
JBrowse link
G Myh7 myosin, heavy polypeptide 7, cardiac muscle, beta multiple interactions ISO Bosentan inhibits the reaction [MYH7 gene mutant form results in increased expression of NPPB protein] CTD PMID:29741611 NCBI chr14:54,970,684...54,994,626
Ensembl chr14:54,970,684...54,994,626
JBrowse link
G Nfix nuclear factor I/X decreases expression ISO Bosentan results in decreased expression of NFIX mRNA CTD PMID:29761207 NCBI chr 8:84,704,712...84,801,238
Ensembl chr 8:84,699,876...84,800,344
JBrowse link
G Nox4 NADPH oxidase 4 decreases expression ISO Bosentan results in decreased expression of NOX4 mRNA CTD PMID:29761207 NCBI chr 7:87,244,430...87,398,710
Ensembl chr 7:87,246,096...87,398,710
JBrowse link
G Nppb natriuretic peptide type B multiple interactions ISO Bosentan inhibits the reaction [MYH7 gene mutant form results in increased expression of NPPB protein] CTD PMID:29741611 NCBI chr 4:147,985,786...147,987,205
Ensembl chr 4:147,985,788...147,987,205
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression ISO Bosentan results in increased expression of NQO1 mRNA CTD PMID:29761207 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 decreases expression ISO Bosentan results in decreased expression of NR1H2 mRNA CTD PMID:29761207 NCBI chr 7:44,549,616...44,553,968
Ensembl chr 7:44,549,616...44,553,951
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 decreases expression ISO Bosentan results in decreased expression of NR1H3 mRNA CTD PMID:29761207 NCBI chr 2:91,184,061...91,202,829
Ensembl chr 2:91,184,061...91,202,834
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression ISO Bosentan results in decreased expression of NR1H4 mRNA CTD PMID:29761207 NCBI chr10:89,454,234...89,533,645
Ensembl chr10:89,454,234...89,533,585
JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) decreases expression ISO Bosentan results in decreased expression of PCK2 mRNA CTD PMID:29761207 NCBI chr14:55,540,263...55,550,020
Ensembl chr14:55,540,266...55,551,242
JBrowse link
G Pglyrp2 peptidoglycan recognition protein 2 affects expression ISO Bosentan affects the expression of PGLYRP2 mRNA CTD PMID:29761207 NCBI chr17:32,412,459...32,424,219
Ensembl chr17:32,412,459...32,424,167
JBrowse link
G Pklr pyruvate kinase liver and red blood cell affects expression ISO Bosentan affects the expression of PKLR mRNA CTD PMID:29761207 NCBI chr 3:89,136,122...89,146,815
Ensembl chr 3:89,136,142...89,146,784
JBrowse link
G Pon1 paraoxonase 1 decreases expression ISO Bosentan results in decreased expression of PON1 mRNA CTD PMID:29761207 NCBI chr 6:5,168,090...5,193,987
Ensembl chr 6:5,168,090...5,193,946
JBrowse link
G Por cytochrome p450 oxidoreductase affects expression ISO Bosentan affects the expression of POR mRNA CTD PMID:29761207 NCBI chr 5:135,670,040...135,735,326
Ensembl chr 5:135,670,033...135,735,326
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma decreases expression ISO Bosentan results in decreased expression of PPARG mRNA CTD PMID:29761207 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha decreases expression ISO Bosentan results in decreased expression of PPARGC1A mRNA CTD PMID:29761207 NCBI chr 5:51,454,249...52,115,853
Ensembl chr 5:51,454,250...51,567,726
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO bosentan inhibits the reaction [Glucose results in increased activity of RELA protein] CTD PMID:12388107 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Sftpa1 surfactant associated protein A1 multiple interactions ISO bosentan inhibits the reaction [Nitric Oxide Donors results in decreased expression of SFTPA1 mRNA]; bosentan inhibits the reaction [Nitric Oxide results in decreased expression of SFTPA1 mRNA]; bosentan inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPA1 mRNA] CTD PMID:15640287 NCBI chr14:41,131,788...41,136,373
Ensembl chr14:41,131,782...41,136,452
JBrowse link
G Sftpb surfactant associated protein B multiple interactions ISO bosentan inhibits the reaction [Nitric Oxide Donors results in decreased expression of SFTPB mRNA]; bosentan inhibits the reaction [Nitric Oxide results in decreased expression of SFTPB mRNA]; bosentan inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPB mRNA] CTD PMID:15640287 NCBI chr 6:72,304,610...72,314,373
Ensembl chr 6:72,304,610...72,314,371
JBrowse link
G Sftpc surfactant associated protein C multiple interactions ISO bosentan inhibits the reaction [Nitric Oxide Donors results in decreased expression of SFTPC mRNA]; bosentan inhibits the reaction [Nitric Oxide results in decreased expression of SFTPC mRNA]; bosentan inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPC mRNA] CTD PMID:15640287 NCBI chr14:70,520,941...70,524,081
Ensembl chr14:70,520,949...70,524,081
JBrowse link
G Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 decreases expression ISO bosentan results in decreased expression of SLC10A1 mRNA
Bosentan results in decreased expression of SLC10A1 mRNA
CTD PMID:27765674 PMID:28369585 PMID:29761207 NCBI chr12:80,953,185...80,968,705
Ensembl chr12:80,953,183...80,968,705
JBrowse link
G Slc22a7 solute carrier family 22 (organic anion transporter), member 7 affects expression ISO Bosentan affects the expression of SLC22A7 mRNA CTD PMID:29761207 NCBI chr17:46,432,185...46,438,477
Ensembl chr17:46,432,183...46,438,457
JBrowse link
G Slc3a2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 increases expression ISO Bosentan results in increased expression of SLC3A2 mRNA; Bosentan results in increased expression of SLC3A2 protein CTD PMID:29761207 NCBI chr19:8,706,882...8,723,369
Ensembl chr19:8,706,882...8,723,369
JBrowse link
G Slc51a solute carrier family 51, alpha subunit increases expression ISO Bosentan results in increased expression of SLC51A mRNA CTD PMID:29761207 NCBI chr16:32,475,578...32,487,879
Ensembl chr16:32,474,504...32,487,879
JBrowse link
G Slc51b solute carrier family 51, beta subunit increases expression ISO Bosentan results in increased expression of SLC51B mRNA CTD PMID:29761207 NCBI chr 9:65,412,753...65,422,773
Ensembl chr 9:65,412,714...65,422,955
JBrowse link
G Slc6a1 solute carrier family 6 (neurotransmitter transporter, GABA), member 1 affects expression ISO Bosentan affects the expression of SLC6A1 mRNA CTD PMID:29761207 NCBI chr 6:114,282,635...114,317,525
Ensembl chr 6:114,282,635...114,317,532
JBrowse link
G Sod1 superoxide dismutase 1, soluble decreases expression ISO Bosentan results in decreased expression of SOD1 mRNA CTD PMID:29761207 NCBI chr16:90,220,762...90,226,333
Ensembl chr16:90,220,754...90,226,329
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial increases expression ISO Bosentan results in increased expression of SOD2 mRNA CTD PMID:29761207 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
G Sult1e1 sulfotransferase family 1E, member 1 affects expression ISO Bosentan affects the expression of SULT1E1 mRNA CTD PMID:29761207 NCBI chr 5:87,575,968...87,591,611
Ensembl chr 5:87,575,969...87,591,594
JBrowse link
G Tat tyrosine aminotransferase affects expression ISO Bosentan affects the expression of TAT mRNA CTD PMID:29761207 NCBI chr 8:109,986,078...109,999,804
Ensembl chr 8:109,990,437...109,999,803
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO bosentan inhibits the reaction [TGFB1 protein results in increased activity of EDN1 protein] CTD PMID:22796455 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP bosentan inhibits the reaction [Doxorubicin results in increased expression of TNF protein] CTD PMID:17974986 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Txn2 thioredoxin 2 decreases expression ISO Bosentan results in decreased expression of TXN2 mRNA CTD PMID:29761207 NCBI chr15:77,915,051...77,928,994
Ensembl chr15:77,915,047...77,929,006
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Bosentan results in increased expression of TXNRD1 mRNA CTD PMID:29761207 NCBI chr10:82,833,951...82,897,724
Ensembl chr10:82,833,951...82,897,712
JBrowse link
G Ugt1a6b UDP glucuronosyltransferase 1 family, polypeptide A6B decreases expression ISO Bosentan results in decreased expression of UGT1A6 mRNA CTD PMID:29761207 NCBI chr 1:88,103,257...88,218,998
Ensembl chr 1:88,103,252...88,219,003
JBrowse link
G Vnn1 vanin 1 affects expression ISO Bosentan affects the expression of VNN1 mRNA CTD PMID:29761207 NCBI chr10:23,894,688...23,905,344
Ensembl chr10:23,894,688...23,905,343
JBrowse link
G Xdh xanthine dehydrogenase decreases expression ISO Bosentan results in decreased expression of XDH mRNA CTD PMID:29761207 NCBI chr17:73,883,895...73,950,397
Ensembl chr17:73,883,895...73,950,196
JBrowse link
enrasentan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ednra endothelin receptor type A multiple interactions ISO enrasentan binds to and results in decreased activity of EDNRA protein CTD PMID:16219361 NCBI chr 8:77,663,029...77,724,452
Ensembl chr 8:77,663,031...77,724,464
JBrowse link
G Ednrb endothelin receptor type B multiple interactions ISO enrasentan binds to and results in decreased activity of EDNRB protein CTD PMID:16219361 NCBI chr14:103,814,615...103,844,508
Ensembl chr14:103,814,625...103,844,402
JBrowse link
losartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 decreases activity
multiple interactions
ISO Losartan results in decreased activity of ABCB11 protein
Losartan inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:23956101 PMID:24014644 NCBI chr 2:69,238,282...69,342,616
Ensembl chr 2:69,238,282...69,342,616
JBrowse link
G Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 multiple interactions
decreases expression
EXP
ISO
Losartan inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of ACE protein]; Losartan inhibits the reaction [Oxygen deficiency results in increased expression of ACE protein]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of ACE mRNA]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of ACE protein]
Losartan results in decreased expression of ACE protein
CTD PMID:25511041 PMID:25655897 PMID:28091615 PMID:28578904 PMID:33007385 NCBI chr11:105,967,948...105,989,964
Ensembl chr11:105,967,945...105,989,964
JBrowse link
G Ace2 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 multiple interactions
increases expression
increases activity
ISO
EXP
Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of ACE2 protein]
Losartan results in increased expression of ACE2 mRNA; Losartan results in increased expression of ACE2 protein
Losartan results in increased activity of ACE2 protein
Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [Oxygen deficiency results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 protein]
CTD PMID:15897343 PMID:16176966 PMID:16221218 PMID:20178811 PMID:22009550 PMID:25511041 PMID:25655897 PMID:28091615 PMID:33007385 NCBI chr  X:164,139,342...164,188,418
Ensembl chr  X:164,139,332...164,188,420
JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta decreases expression
multiple interactions
ISO
EXP
Losartan results in decreased expression of ACTA2 mRNA; Losartan results in decreased expression of ACTA2 protein
Losartan inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]
CTD PMID:15100363 PMID:28091615 PMID:28578904 PMID:33007385 NCBI chr19:34,240,336...34,255,585
Ensembl chr19:34,241,090...34,255,590
JBrowse link
G Actg2 actin, gamma 2, smooth muscle, enteric decreases expression ISO Losartan results in decreased expression of ACTG2 mRNA CTD PMID:15100363 NCBI chr 6:83,512,909...83,536,251
Ensembl chr 6:83,512,905...83,536,265
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression EXP Losartan results in increased expression of ADIPOQ mRNA CTD PMID:19730415 NCBI chr16:23,146,536...23,157,968
Ensembl chr16:23,146,536...23,158,028
JBrowse link
G Adrb2 adrenergic receptor, beta 2 affects expression ISO Losartan affects the expression of ADRB2 protein CTD PMID:9260993 NCBI chr18:62,177,713...62,179,981
Ensembl chr18:62,177,816...62,179,959
JBrowse link
G Afp alpha fetoprotein multiple interactions EXP Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein] CTD PMID:29859236 NCBI chr 5:90,490,714...90,508,907
Ensembl chr 5:90,490,737...90,508,907
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO Losartan inhibits the reaction [Glucose promotes the reaction [Linoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]; Losartan inhibits the reaction [Linoleic Acid promotes the reaction [Glucose promotes the reaction [Azoxymethane results in increased expression of AGER protein]]] CTD PMID:22467055 NCBI chr17:34,597,460...34,600,937
Ensembl chr17:34,597,862...34,600,936
JBrowse link
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) multiple interactions
increases secretion
decreases activity
decreases response to substance
increases expression
decreases expression
ISO
EXP
[Losartan co-treated with ICG 001] inhibits the reaction [AGT protein results in decreased expression of NPHS2 protein]; [Losartan co-treated with ICG 001] inhibits the reaction [AGT protein results in increased expression of S100A4 protein]; [Losartan results in decreased activity of AGTR1 protein] which results in increased expression of AGT protein alternative form; ICG 001 promotes the reaction [Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]]; ICG 001 promotes the reaction [Losartan inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]]; Losartan inhibits the reaction [[AGT protein modified form co-treated with Ascorbic Acid co-treated with Copper Sulfate] results in increased chemical synthesis of [4-hydroxy-2-nonenal binds to AGT protein modified form]]; Losartan inhibits the reaction [[AGT protein modified form co-treated with Ascorbic Acid co-treated with Copper Sulfate] results in increased chemical synthesis of [pyruvamide binds to AGT protein modified form]]; Losartan inhibits the reaction [AGT protein affects the localization of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein modified form promotes the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]]; Losartan inhibits the reaction [AGT protein modified form results in decreased secretion of Nitric Oxide]; Losartan inhibits the reaction [AGT protein modified form results in increased expression of EDN1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of HMOX1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of NFE2L2 protein]; Losartan inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; Losartan inhibits the reaction [AGT protein results in increased expression of ACE protein]; Losartan inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGT protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; Losartan inhibits the reaction [AGT protein results in increased expression of and results in increased activity of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CCL2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of REN protein]; Losartan inhibits the reaction [AGT protein results in increased expression of S100A4 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of TWIST1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of VIM protein]; Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 protein]; Losartan inhibits the reaction [AGT protein results in increased secretion of ICAM1 protein]; Losartan promotes the reaction [AGT protein results in increased expression of VEGFA mRNA]; Losartan promotes the reaction [AGT protein results in increased secretion of VEGFA protein]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of MMP7 protein]]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]]
Losartan results in increased secretion of AGT protein; Losartan results in increased secretion of AGT protein alternative form
[Losartan results in decreased activity of AGT protein] which results in decreased activity of TGFB1 protein; Losartan results in decreased activity of AGT protein
Losartan results in decreased susceptibility to AGT protein modified form
Losartan results in increased expression of AGT protein
Losartan results in decreased activity of AGT protein; Losartan results in decreased activity of AGT protein modified form
Losartan results in decreased expression of AGT protein; Losartan results in decreased expression of AGT protein alternative form; Losartan results in decreased expression of AGT protein modified form
[Lisinopril co-treated with Losartan] results in increased expression of AGT mRNA; [Losartan co-treated with Carvedilol] results in decreased susceptibility to AGT protein modified form; Carvedilol inhibits the reaction [Losartan results in decreased susceptibility to AGT protein modified form]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Losartan inhibits the reaction [[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein]; Losartan inhibits the reaction [AGT protein affects the abundance of Cholesterol]; Losartan inhibits the reaction [AGT protein affects the localization of Calcium]; Losartan inhibits the reaction [AGT protein affects the localization of Lipids]; Losartan inhibits the reaction [AGT protein alternative form results in increased expression of PDGFA mRNA alternative form]; Losartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; Losartan inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]; Losartan inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 mRNA]; Losartan inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 protein]; Losartan inhibits the reaction [AGT protein modified form results in increased phosphorylation of GSK3B protein]; Losartan inhibits the reaction [AGT protein modified form results in increased phosphorylation of MAPT protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of CPT1A mRNA]; Losartan inhibits the reaction [AGT protein results in increased abundance of Fatty Acids, Nonesterified]; Losartan inhibits the reaction [AGT protein results in increased abundance of Glycerol]; Losartan inhibits the reaction [AGT protein results in increased abundance of Norepinephrine]; Losartan inhibits the reaction [AGT protein results in increased abundance of Triglycerides]; Losartan inhibits the reaction [AGT protein results in increased activity of CREB1 protein]; Losartan inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of ATP1A1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of ENG protein]; Losartan inhibits the reaction [AGT protein results in increased expression of FASN mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of FOS protein]; Losartan inhibits the reaction [AGT protein results in increased expression of HMGCR mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of HSPA5 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of MYLK protein]; Losartan inhibits the reaction [AGT protein results in increased expression of PARP1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of PDGFB mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PDGFD mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PDGFRB mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of POSTN mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PPARA mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PPARG mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PPARGC1A mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PTHLH mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PTHLH protein]; Losartan inhibits the reaction [AGT protein results in increased expression of REG3G mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of SREBF1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of TSC22D1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of UCP2 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of UCP3 mRNA]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of EIF2S1 protein]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of SREBF1 protein]; Losartan inhibits the reaction [AGT protein results in increased secretion of COL3A1 protein]; Losartan inhibits the reaction [AGT protein results in increased secretion of PRL protein]; Losartan inhibits the reaction [Carvedilol results in decreased susceptibility to AGT protein modified form]; Losartan inhibits the reaction [Ethanol results in increased secretion of AGT protein alternative form]; Losartan inhibits the reaction [Folic Acid results in increased localization of [AGT protein binds to AGTR1A protein]]; Losartan inhibits the reaction [Folic Acid results in increased localization of AGT protein]; Losartan inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; Losartan inhibits the reaction [Sodium Chloride results in increased expression of AGT protein]; Losartan inhibits the reaction [Tobacco Smoke Pollution results in increased expression of AGT protein]; Losartan promotes the reaction [AGTR2 protein binds to AGT protein]; Losartan promotes the reaction [Isoproterenol results in increased expression of AGT protein]
Losartan inhibits the reaction [AGT protein affects the localization of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in decreased abundance of angiotensin I (1-7)]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of NFE2L2 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of NPHS1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of PODXL protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of WT1 protein]; Losartan inhibits the reaction [AGT protein results in increased activity of PARP1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of ACE protein]; Losartan inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGT protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AKT2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CCL2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of DES protein]; Losartan inhibits the reaction [AGT protein results in increased expression of FOS protein]; Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of RELA protein]; Losartan inhibits the reaction [AGT protein results in increased expression of REN1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of SOD3 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of TWIST1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of VIM protein]; Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 protein]; Losartan inhibits the reaction [Silicon Dioxide results in decreased expression of AGT protein alternative form]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of AGT protein]
CTD PMID:1387008 PMID:7965263 PMID:8403307 PMID:8952583 PMID:9124547 PMID:9176287 PMID:9519251 PMID:9533614 PMID:10082498 PMID:10400907 PMID:10517737 PMID:11463773 PMID:11709406 PMID:11967826 PMID:12084390 PMID:12411096 PMID:12431451 PMID:12692751 PMID:14630723 PMID:14722030 PMID:15121739 PMID:15213268 PMID:15361886 PMID:15502880 PMID:15528393 PMID:15539634 PMID:15728788 PMID:15741261 PMID:15897343 PMID:16176966 PMID:16221218 PMID:16251426 PMID:16539842 PMID:17043664 PMID:17224469 PMID:17481528 PMID:17666345 PMID:18060435 PMID:18267125 PMID:18511912 PMID:19109942 PMID:19183357 PMID:19298698 PMID:20178811 PMID:20232302 PMID:21047287 PMID:21152098 PMID:21166975 PMID:21613610 PMID:21613793 PMID:22982071 PMID:22982863 PMID:23300732 PMID:23875703 PMID:25398788 PMID:26464165 PMID:27798352 PMID:28578904 PMID:29609002 PMID:31144504 PMID:33007385 NCBI chr 8:124,556,587...124,569,706
Ensembl chr 8:124,556,534...124,569,706
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions
decreases activity
increases expression
decreases expression
EXP
ISO
Losartan binds to and results in decreased activity of AGTR1A protein; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; Losartan inhibits the reaction [Hydrogen Peroxide results in increased expression of AGTR1A mRNA]; Losartan inhibits the reaction [Oxygen deficiency results in increased expression of AGTR1 protein]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of AGTR1 protein]
Losartan results in decreased activity of AGTR1 protein
[Losartan results in decreased activity of AGTR1 protein] which results in decreased abundance of Aldosterone; [Losartan results in decreased activity of AGTR1 protein] which results in increased expression of AGT protein alternative form; [Losartan results in decreased activity of AGTR1 protein] which results in increased expression of REN protein; Losartan binds to and results in decreased activity of AGTR1 protein; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]
Losartan results in increased expression of AGTR1 mRNA; Losartan results in increased expression of AGTR1A mRNA
[Cilazapril co-treated with Losartan] promotes the reaction [Doxorubicin results in increased expression of AGTR1 mRNA]; Losartan binds to and results in decreased activity of AGTR1 protein; Losartan binds to and results in decreased activity of AGTR1A protein; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased expression of AGTR1A mRNA]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased expression of AGTR1A protein]; Losartan inhibits the reaction [Doxorubicin results in increased expression of AGTR1 mRNA]; Losartan inhibits the reaction [Doxorubicin results in increased expression of AGTR1 protein]; Losartan inhibits the reaction [Folic Acid results in increased localization of [AGT protein binds to AGTR1A protein]]
Losartan results in decreased expression of AGTR1 protein; Losartan results in decreased expression of AGTR1A mRNA; Losartan results in decreased expression of AGTR1A protein
CTD PMID:9124547 PMID:9533614 PMID:10821809 PMID:11893553 PMID:12930639 PMID:15157388 PMID:15331931 PMID:15528393 PMID:15728788 PMID:15807884 PMID:15809360 PMID:18267125 PMID:18300857 PMID:18765277 PMID:22306536 PMID:25511041 PMID:28091615 PMID:28578904 PMID:33007385 NCBI chr13:30,336,356...30,382,867
Ensembl chr13:30,336,441...30,382,867
JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions
increases expression
decreases expression
ISO
EXP
[Losartan co-treated with Cilazapril] inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA]; Losartan inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA]; Losartan promotes the reaction [AGTR2 protein binds to AGT protein]
Losartan inhibits the reaction [Oxygen deficiency results in decreased expression of AGTR2 protein]
Losartan results in increased expression of AGTR2 protein
Losartan results in decreased expression of AGTR2 mRNA
CTD PMID:9336375 PMID:11967826 PMID:15331931 PMID:18300857 PMID:25511041 NCBI chr  X:21,484,624...21,488,833
Ensembl chr  X:21,484,544...21,489,164
JBrowse link
G Akt2 thymoma viral proto-oncogene 2 multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of AKT2 protein] CTD PMID:28578904 NCBI chr 7:27,591,552...27,640,826
Ensembl chr 7:27,591,552...27,640,826
JBrowse link
G Alb albumin affects binding ISO Losartan binds to ALB protein; Losartan binds to ALB protein modified form CTD PMID:27470663 NCBI chr 5:90,460,870...90,476,602
Ensembl chr 5:90,460,897...90,476,602
JBrowse link
G Alox15 arachidonate 15-lipoxygenase decreases expression ISO Losartan results in decreased expression of ALOX15 mRNA; Losartan results in decreased expression of ALOX15 protein CTD PMID:15100363 NCBI chr11:70,344,147...70,390,538
Ensembl chr11:70,344,152...70,352,031
JBrowse link
G Alox5 arachidonate 5-lipoxygenase decreases expression ISO Losartan results in decreased expression of ALOX5 protein CTD PMID:21377515 NCBI chr 6:116,410,071...116,461,178
Ensembl chr 6:116,410,077...116,461,178
JBrowse link
G Ambp alpha 1 microglobulin/bikunin precursor decreases expression
multiple interactions
ISO Losartan results in decreased expression of AMBP protein
benazepril promotes the reaction [Losartan results in decreased expression of AMBP protein]; Losartan promotes the reaction [benazepril results in decreased expression of AMBP protein]
CTD PMID:16303729 NCBI chr 4:63,143,275...63,154,172
Ensembl chr 4:63,143,275...63,154,799
JBrowse link
G Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of ATP1A1 mRNA] CTD PMID:14630723 NCBI chr 3:101,576,219...101,604,707
Ensembl chr 3:101,576,219...101,604,684
JBrowse link
G Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide increases expression ISO Losartan results in increased expression of ATP1A2 mRNA; Losartan results in increased expression of ATP1A2 protein CTD PMID:18418421 NCBI chr 1:172,271,709...172,298,064
Ensembl chr 1:172,271,709...172,298,064
JBrowse link
G Atp1a3 ATPase, Na+/K+ transporting, alpha 3 polypeptide decreases expression ISO Losartan results in decreased expression of ATP1A3 mRNA; Losartan results in decreased expression of ATP1A3 protein CTD PMID:18418421 NCBI chr 7:24,978,167...25,006,077
Ensembl chr 7:24,978,167...25,005,958
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO Losartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAK1 mRNA] CTD PMID:15502641 NCBI chr17:27,019,812...27,028,627
Ensembl chr17:27,019,810...27,029,009
JBrowse link
G Bax BCL2-associated X protein multiple interactions
increases expression
decreases expression
ISO Losartan inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]; Losartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAX mRNA]
Losartan results in increased expression of BAX protein
Losartan results in decreased expression of BAX mRNA
CTD PMID:12623880 PMID:12845756 PMID:15502641 PMID:17784886 PMID:19298698 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
affects expression
increases expression
decreases expression
ISO Losartan promotes the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of BCL2 mRNA]
Losartan affects the expression of BCL2 protein
Losartan results in increased expression of BCL2 protein
Losartan results in decreased expression of BCL2 protein
CTD PMID:12623880 PMID:15502641 PMID:19298698 PMID:21153712 PMID:22000973 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions ISO Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 mRNA]; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 protein] CTD PMID:27412937 NCBI chr 2:133,552,159...133,562,896
Ensembl chr 2:133,552,159...133,562,885
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP [KN 93 co-treated with Losartan] inhibits the reaction [bisphenol A results in increased phosphorylation of CAMK2A protein]; Losartan inhibits the reaction [bisphenol A results in increased phosphorylation of CAMK2A protein] CTD PMID:25103225 NCBI chr18:60,925,307...60,988,152
Ensembl chr18:60,925,618...60,988,152
JBrowse link
G Casp3 caspase 3 increases cleavage
decreases activity
multiple interactions
ISO Losartan results in increased cleavage of CASP3 protein
Losartan results in decreased activity of CASP3 protein
Losartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]
CTD PMID:12623880 PMID:23300732 PMID:23875703 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp8 caspase 8 decreases activity ISO Losartan results in decreased activity of CASP8 protein CTD PMID:23875703 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503
JBrowse link
G Casp9 caspase 9 increases cleavage ISO Losartan results in increased cleavage of CASP9 protein CTD PMID:12623880 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cat catalase decreases expression
multiple interactions
ISO Losartan results in decreased expression of CAT protein
Losartan inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
CTD PMID:23875703 PMID:30958922 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 decreases expression
multiple interactions
ISO
EXP
Losartan results in decreased expression of CCL2 mRNA; Losartan results in decreased expression of CCL2 protein
Losartan inhibits the reaction [AGT protein results in increased expression of CCL2 protein]
Losartan inhibits the reaction [Estrogens deficiency results in increased expression of CCL2 protein]; Losartan inhibits the reaction [Ethylene Glycol results in increased expression of CCL2 protein]
CTD PMID:10925121 PMID:16284884 PMID:17922026 PMID:19553526 PMID:28578904 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Ccl3 chemokine (C-C motif) ligand 3 multiple interactions ISO Losartan inhibits the reaction [Estrogens deficiency results in increased expression of CCL3 protein] CTD PMID:19553526 NCBI chr11:83,647,843...83,649,378
Ensembl chr11:83,647,844...83,649,355
JBrowse link
G Ccl5 chemokine (C-C motif) ligand 5 multiple interactions ISO Losartan inhibits the reaction [Ethylene Glycol results in increased expression of CCL5 protein] CTD PMID:16284884 NCBI chr11:83,525,778...83,530,518
Ensembl chr11:83,525,778...83,530,518
JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA] CTD PMID:29859236 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Ccr2 chemokine (C-C motif) receptor 2 decreases expression ISO Losartan results in decreased expression of CCR2 mRNA CTD PMID:17922026 NCBI chr 9:124,101,918...124,109,140
Ensembl chr 9:124,101,950...124,113,557
JBrowse link
G Cd36 CD36 molecule increases expression
decreases expression
multiple interactions
ISO
EXP
Losartan results in increased expression of CD36 mRNA
Losartan results in decreased expression of CD36 mRNA
Losartan promotes the reaction [[Dietary Fats co-treated with Cholesterol] results in increased expression of CD36 mRNA]
T 0070907 inhibits the reaction [Losartan results in increased expression of CD36 mRNA]
CTD PMID:18302760 PMID:22124178 NCBI chr 5:17,781,690...17,888,959
Ensembl chr 5:17,781,690...17,888,801
JBrowse link
G Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) decreases expression ISO Losartan results in decreased expression of CD74 mRNA CTD PMID:15100363 NCBI chr18:60,803,849...60,812,652
Ensembl chr18:60,803,848...60,812,652
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO
EXP
Losartan inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]
Losartan inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; Losartan inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]
CTD PMID:28578904 PMID:33007385 NCBI chr 8:106,603,350...106,670,247
Ensembl chr 8:106,603,351...106,670,246
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) multiple interactions ISO Losartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN1A protein] CTD PMID:33380422 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A multiple interactions ISO Losartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN2A protein] CTD PMID:33380422 NCBI chr 4:89,274,473...89,294,619
Ensembl chr 4:89,274,471...89,294,653
JBrowse link
G Col1a1 collagen, type I, alpha 1 decreases expression
multiple interactions
ISO
EXP
Losartan results in decreased expression of COL1A1 mRNA
Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of COL1A1 mRNA]
CTD PMID:15100363 PMID:18300870 PMID:23585870 NCBI chr11:94,936,224...94,953,042
Ensembl chr11:94,936,224...94,953,042
JBrowse link
G Col3a1 collagen, type III, alpha 1 decreases expression
multiple interactions
ISO
EXP
Losartan results in decreased expression of COL3A1 mRNA
Losartan inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]
Losartan inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of COL3A1 mRNA]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of COL3A1 protein]
Losartan inhibits the reaction [AGT protein results in increased secretion of COL3A1 protein]; Losartan inhibits the reaction [Paraquat results in increased expression of COL3A1 protein]
CTD PMID:15100363 PMID:16539842 PMID:23585870 PMID:25233898 PMID:28578904 PMID:33007385 NCBI chr 1:45,311,538...45,349,706
Ensembl chr 1:45,311,538...45,349,706
JBrowse link
G Col4a1 collagen, type IV, alpha 1 decreases expression ISO Losartan results in decreased expression of COL4A1 mRNA CTD PMID:16191423 NCBI chr 8:11,198,423...11,312,889
Ensembl chr 8:11,198,423...11,312,826
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver multiple interactions ISO Losartan inhibits the reaction [AGT protein results in decreased expression of CPT1A mRNA] CTD PMID:19109942 NCBI chr19:3,322,326...3,385,735
Ensembl chr19:3,322,334...3,385,733
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased activity of CREB1 protein]; Losartan inhibits the reaction [Folic Acid results in increased activity of CREB1 protein] CTD PMID:15728788 NCBI chr 1:64,532,794...64,604,548
Ensembl chr 1:64,532,645...64,604,548
JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 multiple interactions ISO
EXP
Losartan inhibits the reaction [AGT protein affects the localization of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of and results in increased activity of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 mRNA]
Losartan inhibits the reaction [AGT protein affects the localization of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 protein]
CTD PMID:28578904 NCBI chr 9:120,933,400...120,960,507
Ensembl chr 9:120,929,216...120,960,507
JBrowse link
G Cubn cubilin (intrinsic factor-cobalamin receptor) multiple interactions ISO Losartan inhibits the reaction [Cadmium results in decreased expression of CUBN protein] CTD PMID:24093454 NCBI chr 2:13,276,338...13,491,876
Ensembl chr 2:13,276,338...13,491,813
JBrowse link
G Cxcl1 chemokine (C-X-C motif) ligand 1 multiple interactions ISO Losartan inhibits the reaction [Estrogens deficiency results in increased expression of CXCL1 protein] CTD PMID:19553526 NCBI chr 5:90,891,245...90,893,121
Ensembl chr 5:90,891,241...90,893,115
JBrowse link
G Cycs cytochrome c, somatic increases expression ISO Losartan results in increased expression of CYCS protein CTD PMID:18971572 NCBI chr 6:50,562,563...50,566,569
Ensembl chr 6:50,562,563...50,566,538
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Losartan results in increased expression of CYP1A1 mRNA CTD PMID:9860486 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 increases metabolic processing
increases hydroxylation
multiple interactions
affects metabolic processing
ISO CYP2C9 protein results in increased metabolism of Losartan
CYP2C9 protein results in increased hydroxylation of Losartan
CYP2C9 gene mutant form inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Losartan]; Resveratrol inhibits the reaction [CYP2C9 protein results in increased metabolism of Losartan]
CYP2C9 protein affects the metabolism of Losartan
CTD PMID:19082874 PMID:19715737 PMID:20405111 PMID:20716633 PMID:21321060 PMID:25994031 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 increases metabolic processing
increases hydroxylation
multiple interactions
affects metabolic processing
ISO CYP2C9 protein results in increased metabolism of Losartan
CYP2C9 protein results in increased hydroxylation of Losartan
CYP2C9 gene mutant form inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Losartan]; resveratrol inhibits the reaction [CYP2C9 protein results in increased metabolism of Losartan]
CYP2C9 protein affects the metabolism of Losartan
CTD PMID:19082874 PMID:19715737 PMID:20405111 PMID:20716633 PMID:21321060 PMID:25994031 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072
JBrowse link
G Dcn decorin decreases expression ISO Losartan results in decreased expression of DCN mRNA CTD PMID:15100363 NCBI chr10:97,479,500...97,518,163
Ensembl chr10:97,479,609...97,518,143
JBrowse link
G Des desmin multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of DES protein] CTD PMID:28578904 NCBI chr 1:75,360,292...75,368,579
Ensembl chr 1:75,360,329...75,368,579
JBrowse link
G Edn1 endothelin 1 decreases expression
multiple interactions
ISO Losartan results in decreased expression of EDN1 mRNA; Losartan results in decreased expression of EDN1 protein
Losartan inhibits the reaction [Nitroglycerin results in increased expression of EDN1 protein]
Losartan inhibits the reaction [AGT protein modified form results in increased expression of EDN1 protein]
CTD PMID:11369837 PMID:12901495 PMID:16191423 PMID:17666345 PMID:18971572 NCBI chr13:42,301,476...42,307,990
Ensembl chr13:42,301,476...42,307,990
JBrowse link
G Ednra endothelin receptor type A multiple interactions
decreases expression
ISO Atorvastatin promotes the reaction [Losartan results in decreased expression of EDNRA mRNA]; Losartan promotes the reaction [Atorvastatin results in decreased expression of EDNRA mRNA] CTD PMID:23091284 NCBI chr 8:77,663,029...77,724,452
Ensembl chr 8:77,663,031...77,724,464
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased phosphorylation of EIF2S1 protein] CTD PMID:25398788 NCBI chr12:78,862,072...78,887,010
Ensembl chr12:78,861,819...78,887,010
JBrowse link
G Eln elastin decreases expression ISO Losartan results in decreased expression of ELN mRNA CTD PMID:15100363 NCBI chr 5:134,702,595...134,747,368
Ensembl chr 5:134,702,593...134,747,323
JBrowse link
G Eng endoglin multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of ENG protein] CTD PMID:15539634 NCBI chr 2:32,646,595...32,682,669
Ensembl chr 2:32,646,595...32,682,669
JBrowse link
G F3 coagulation factor III decreases expression
multiple interactions
ISO Losartan results in decreased expression of F3 mRNA; Losartan results in decreased expression of F3 protein
Losartan inhibits the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]; Losartan inhibits the reaction [AGT protein modified form promotes the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]]
CTD PMID:18060435 PMID:22188725 NCBI chr 3:121,723,537...121,735,052
Ensembl chr 3:121,723,537...121,735,048
JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) decreases expression ISO Losartan results in decreased expression of FASLG mRNA CTD PMID:10925121 NCBI chr 1:161,780,691...161,788,495
Ensembl chr 1:161,780,689...161,788,495
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of FASN mRNA] CTD PMID:19109942 NCBI chr11:120,805,958...120,825,166
Ensembl chr11:120,805,846...120,824,547
JBrowse link
G Flt1 FMS-like tyrosine kinase 1 decreases expression EXP Losartan results in decreased expression of FLT1 mRNA; Losartan results in decreased expression of FLT1 protein CTD PMID:19771429 NCBI chr 5:147,561,604...147,726,438
Ensembl chr 5:147,561,604...147,726,011
JBrowse link
G Flt4 FMS-like tyrosine kinase 4 decreases expression EXP Losartan results in decreased expression of FLT4 mRNA CTD PMID:19771429 NCBI chr11:49,609,679...49,652,739
Ensembl chr11:49,609,263...49,652,739
JBrowse link
G Fn1 fibronectin 1 decreases expression ISO Losartan results in decreased expression of FN1 mRNA; Losartan results in decreased expression of FN1 protein CTD PMID:16191423 NCBI chr 1:71,585,473...71,653,280
Ensembl chr 1:71,585,520...71,653,200
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions EXP
ISO
Losartan inhibits the reaction [AGT protein results in increased expression of FOS protein]; Losartan inhibits the reaction [Furosemide results in increased expression of FOS protein]; Losartan inhibits the reaction [Polyethylene Glycols results in increased expression of FOS protein] CTD PMID:11463773 PMID:15528393 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression ISO Losartan results in increased expression of GJA1 protein CTD PMID:18971572 NCBI chr10:56,377,300...56,390,419
Ensembl chr10:56,377,330...56,402,513
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions ISO
EXP
Losartan inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]
Losartan inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]
CTD PMID:15573910 PMID:29859236 NCBI chr15:76,696,726...76,699,675
Ensembl chr15:76,695,716...76,699,686
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO Losartan inhibits the reaction [AGT protein modified form results in increased phosphorylation of GSK3B protein] CTD PMID:22982863 NCBI chr16:38,089,001...38,246,084
Ensembl chr16:38,089,001...38,246,084
JBrowse link
G H2-Ea histocompatibility 2, class II antigen E alpha decreases expression ISO Losartan results in decreased expression of RT1-DA mRNA CTD PMID:15100363 NCBI chr17:34,341,952...34,344,645
Ensembl chr17:34,341,959...34,344,645
JBrowse link
G H2-T23 histocompatibility 2, T region locus 23 decreases expression ISO Losartan results in decreased expression of RT1-S3 mRNA CTD PMID:15100363 NCBI chr17:36,029,977...36,032,701
Ensembl chr17:36,029,773...36,032,855
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions ISO Losartan inhibits the reaction [Cadmium results in increased expression of HAVCR1] CTD PMID:24093454 NCBI chr11:46,739,822...46,779,578
Ensembl chr11:46,735,080...46,779,578
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of HMGCR mRNA] CTD PMID:19109942 NCBI chr13:96,648,962...96,670,936
Ensembl chr13:96,648,967...96,670,936
JBrowse link
G Hmox1 heme oxygenase 1 increases activity
multiple interactions
increases expression
ISO Losartan results in increased activity of HMOX1 protein
Losartan inhibits the reaction [AGT protein results in decreased expression of HMOX1 protein]
Losartan results in increased expression of HMOX1 mRNA
cobaltiprotoporphyrin promotes the reaction [Losartan results in increased activity of HMOX1 protein]; cobaltiprotoporphyrin promotes the reaction [Losartan results in increased expression of HMOX1 mRNA]
CTD PMID:19804535 PMID:28578904 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hspa5 heat shock protein 5 multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of HSPA5 protein] CTD PMID:25398788 NCBI chr 2:34,772,090...34,776,529
Ensembl chr 2:34,771,970...34,777,547
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases secretion
ISO Losartan inhibits the reaction [AGT protein results in increased secretion of ICAM1 protein]
Losartan results in decreased secretion of ICAM1 protein
CTD PMID:10517737 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
JBrowse link
G Ifng interferon gamma increases expression ISO Losartan results in increased expression of IFNG protein CTD PMID:23875703 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il10 interleukin 10 increases expression ISO Losartan results in increased expression of IL10 mRNA CTD PMID:18971572 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il1a interleukin 1 alpha multiple interactions
decreases expression
ISO Losartan inhibits the reaction [IL1A protein results in increased expression of VEGFA mRNA]; Losartan inhibits the reaction [IL1A protein results in increased expression of VEGFA protein]
Losartan results in decreased expression of IL1A protein
CTD PMID:17299153 PMID:23875703 NCBI chr 2:129,299,609...129,310,186
Ensembl chr 2:129,299,610...129,309,972
JBrowse link
G Il6 interleukin 6 decreases expression
increases expression
multiple interactions
EXP
ISO
Losartan results in decreased expression of IL6 mRNA
Losartan results in increased expression of IL6 protein
Losartan inhibits the reaction [bisphenol A results in increased expression of IL6 mRNA]; Losartan inhibits the reaction [Ethylene Glycol results in increased expression of IL6 protein]
CTD PMID:16284884 PMID:21479465 PMID:23875703 PMID:30677511 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Itga3 integrin alpha 3 decreases expression ISO Losartan results in decreased expression of ITGA3 protein CTD PMID:15100363 NCBI chr11:95,044,475...95,076,844
Ensembl chr11:95,044,474...95,076,801
JBrowse link
G Itga6 integrin alpha 6 decreases expression ISO Losartan results in decreased expression of ITGA6 protein CTD PMID:15100363 NCBI chr 2:71,786,886...71,858,427
Ensembl chr 2:71,745,616...71,858,416
JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO losartan inhibits the reaction [Angiotensin II increases phosphorylation of JAK2 protein in liver] RGD PMID:22613986 RGD:127285667 NCBI chr19:29,251,803...29,313,095
Ensembl chr19:29,251,828...29,313,080
JBrowse link
G Kdr kinase insert domain protein receptor multiple interactions ISO Losartan inhibits the reaction [Cyclosporine results in increased expression of KDR mRNA] CTD PMID:12110003 NCBI chr 5:75,932,827...75,979,072
Ensembl chr 5:75,932,827...75,978,458
JBrowse link
G Kras Kirsten rat sarcoma viral oncogene homolog multiple interactions ISO Losartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN1A protein]; Losartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN2A protein] CTD PMID:33380422 NCBI chr 6:145,216,699...145,250,420
Ensembl chr 6:145,216,699...145,250,239
JBrowse link
G Lox lysyl oxidase decreases expression ISO Losartan results in decreased expression of LOX mRNA CTD PMID:15100363 NCBI chr18:52,516,060...52,529,867
Ensembl chr18:52,516,067...52,529,867
JBrowse link
G Lum lumican decreases expression ISO Losartan results in decreased expression of LUM mRNA CTD PMID:15100363 NCBI chr10:97,565,501...97,572,703
Ensembl chr10:97,565,128...97,572,703
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
increases activity
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Losartan results in increased phosphorylation of MAPK1 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]
Losartan results in increased activity of MAPK1 protein
Losartan inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein]
CTD PMID:11711055 PMID:16079071 PMID:18267125 PMID:18511912 PMID:20056918 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk14 mitogen-activated protein kinase 14 decreases expression ISO Losartan results in decreased expression of MAPK14 protein CTD PMID:28091615 NCBI chr17:28,691,342...28,748,405
Ensembl chr17:28,691,329...28,748,406
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
increases activity
ISO Losartan inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK3 protein]
Losartan results in increased phosphorylation of MAPK3 protein
Losartan results in increased activity of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Losartan results in increased phosphorylation of MAPK3 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]
CTD PMID:11711055 PMID:16079071 PMID:18267125 PMID:18511912 PMID:20056918 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Losartan inhibits the reaction [AGT protein modified form results in increased phosphorylation of MAPT protein] CTD PMID:22982863 NCBI chr11:104,229,409...104,332,090
Ensembl chr11:104,231,390...104,332,090
JBrowse link
G Mas1 MAS1 oncogene multiple interactions EXP Losartan inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; Losartan inhibits the reaction [Silicon Dioxide results in decreased expression of MAS1 protein] CTD PMID:33007385 NCBI chr17:12,838,841...12,868,150
Ensembl chr17:12,841,079...12,868,143
JBrowse link
G Mgp matrix Gla protein decreases expression ISO Losartan results in decreased expression of MGP mRNA CTD PMID:15100363 NCBI chr 6:136,872,435...136,875,823
Ensembl chr 6:136,872,435...136,875,823
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO
EXP
Losartan inhibits the reaction [[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased activity of MMP2 protein]
Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of MMP2 protein]; Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 mRNA]
CTD PMID:12930639 PMID:16251426 PMID:23585870 PMID:29859236 NCBI chr 8:92,827,290...92,853,421
Ensembl chr 8:92,827,291...92,853,420
JBrowse link
G Mmp23 matrix metallopeptidase 23 decreases expression ISO Losartan results in decreased expression of MMP23 mRNA CTD PMID:15100363 NCBI chr 4:155,650,655...155,654,539
Ensembl chr 4:155,650,655...155,653,384
JBrowse link
G Mmp7 matrix metallopeptidase 7 multiple interactions ISO
EXP
ICG 001 promotes the reaction [Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]]; Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of MMP7 protein]] CTD PMID:28578904 NCBI chr 9:7,692,090...7,699,585
Ensembl chr 9:7,692,090...7,699,585
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions
ISO
EXP
Losartan results in decreased expression of MMP9 mRNA
Losartan inhibits the reaction [Paraquat results in increased expression of MMP9 mRNA]
Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]
CTD PMID:18971572 PMID:23585870 PMID:25233898 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850
JBrowse link
G Myc myelocytomatosis oncogene affects expression ISO Losartan affects the expression of MYC protein CTD PMID:22000973 NCBI chr15:61,985,341...61,990,361
Ensembl chr15:61,985,391...61,990,374
JBrowse link
G Myh11 myosin, heavy polypeptide 11, smooth muscle decreases expression ISO Losartan results in decreased expression of MYH11 mRNA CTD PMID:15100363 NCBI chr16:14,194,527...14,292,188
Ensembl chr16:14,194,535...14,291,372
JBrowse link
G Myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha multiple interactions ISO Losartan inhibits the reaction [Streptozocin results in decreased expression of MYH6 mRNA]; Losartan inhibits the reaction [Streptozocin results in decreased expression of MYH6 protein] CTD PMID:15362513 NCBI chr14:54,941,921...54,968,017
Ensembl chr14:54,941,921...54,966,927
JBrowse link
G Myh7 myosin, heavy polypeptide 7, cardiac muscle, beta multiple interactions ISO Losartan inhibits the reaction [Streptozocin results in increased expression of MYH7 mRNA]; Losartan inhibits the reaction [Streptozocin results in increased expression of MYH7 protein] CTD PMID:15362513 NCBI chr14:54,970,684...54,994,626
Ensembl chr14:54,970,684...54,994,626
JBrowse link
G Mylk myosin, light polypeptide kinase multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of MYLK protein] CTD PMID:18511912 NCBI chr16:34,745,199...35,002,436
Ensembl chr16:34,745,210...35,002,420
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions EXP
ISO
Losartan inhibits the reaction [Hydrogen Peroxide results in increased expression of NCF1 mRNA]
Losartan inhibits the reaction [Ethanol affects the localization of NCF1 protein]
CTD PMID:22306536 PMID:22497828 PMID:22982071 NCBI chr 5:134,220,053...134,229,628
Ensembl chr 5:134,220,053...134,229,625
JBrowse link
G Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 multiple interactions ISO Losartan inhibits the reaction [Streptozocin results in decreased expression of NDST1 protein] CTD PMID:15793251 NCBI chr18:60,684,494...60,749,035
Ensembl chr18:60,684,494...60,748,650
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 decreases expression
multiple interactions
ISO
EXP
Losartan results in decreased expression of NFE2L2 mRNA
Losartan inhibits the reaction [AGT protein results in decreased expression of NFE2L2 protein]
CTD PMID:18765277 PMID:28578904 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO
EXP
Losartan inhibits the reaction [Ethylene Glycol results in increased expression of NFKB1 protein]
Losartan inhibits the reaction [Diethylnitrosamine results in decreased expression of NFKB1 protein]
CTD PMID:16284884 PMID:29859236 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547
JBrowse link
G Nos1 nitric oxide synthase 1, neuronal increases phosphorylation
multiple interactions
ISO Losartan results in increased phosphorylation of NOS1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Losartan results in increased phosphorylation of NOS1 protein]
CTD PMID:20056918 NCBI chr 5:117,866,839...117,958,840
Ensembl chr 5:117,781,032...117,958,840
JBrowse link
G Nos2 nitric oxide synthase 2, inducible affects expression
decreases expression
increases expression
ISO Losartan affects the expression of NOS2 mRNA
Losartan results in decreased expression of NOS2 mRNA; Losartan results in decreased expression of NOS2 protein
Losartan results in increased expression of NOS2 protein
CTD PMID:12198324 PMID:16191423 PMID:18390819 PMID:21377515 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell affects expression
increases expression
multiple interactions
increases phosphorylation
ISO Losartan affects the expression of NOS3 mRNA
Losartan results in increased expression of NOS3 mRNA
[Losartan co-treated with Atorvastatin] results in increased expression of NOS3 mRNA; Losartan inhibits the reaction [Sodium Chloride results in decreased expression of NOS3 protein]
Losartan results in increased phosphorylation of NOS3 protein
CTD PMID:12198324 PMID:18390819 PMID:18971572 PMID:20232302 PMID:23091284 NCBI chr 5:24,364,816...24,384,474
Ensembl chr 5:24,364,810...24,384,474
JBrowse link
G Nphs2 nephrosis 2, podocin multiple interactions ISO [Losartan co-treated with ICG 001] inhibits the reaction [AGT protein results in decreased expression of NPHS2 protein] CTD PMID:28578904 NCBI chr 1:156,310,535...156,328,035
Ensembl chr 1:156,310,727...156,328,035
JBrowse link
G Nppa natriuretic peptide type A multiple interactions
decreases expression
ISO Losartan inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPA mRNA]
Losartan results in decreased expression of NPPA protein
CTD PMID:12198334 NCBI chr 4:148,000,722...148,002,074
Ensembl chr 4:148,000,722...148,002,079
JBrowse link
G Nppb natriuretic peptide type B multiple interactions
decreases expression
ISO [Atenolol co-treated with Losartan co-treated with Doxazosin] results in decreased expression of NPPB mRNA; [Losartan co-treated with Doxazosin] results in decreased expression of NPPB mRNA; [Losartan co-treated with Nifedipine] results in decreased expression of NPPB mRNA; Losartan inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPB mRNA]
Losartan results in decreased expression of NPPB mRNA; Losartan results in decreased expression of NPPB protein
CTD PMID:12198334 PMID:15969258 PMID:17666919 NCBI chr 4:147,985,786...147,987,205
Ensembl chr 4:147,985,788...147,987,205
JBrowse link
G Npr1 natriuretic peptide receptor 1 affects response to substance EXP NPR1 protein mutant form affects the susceptibility to Losartan CTD PMID:20881240 NCBI chr 3:90,450,591...90,465,928
Ensembl chr 3:90,450,591...90,465,866
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression ISO Losartan results in increased expression of NR1H3 protein CTD PMID:28091615 NCBI chr 2:91,184,061...91,202,829
Ensembl chr 2:91,184,061...91,202,834
JBrowse link
G Nrf1 nuclear respiratory factor 1 increases expression ISO Losartan results in increased expression of NRF1 mRNA CTD PMID:18765277 NCBI chr 6:30,047,985...30,153,458
Ensembl chr 6:30,047,988...30,153,458
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions EXP
ISO
Losartan inhibits the reaction [AGT protein results in increased activity of PARP1 protein]
Losartan inhibits the reaction [AGT protein results in increased expression of PARP1 protein]
CTD PMID:15502880 PMID:21613793 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Pdgfa platelet derived growth factor, alpha multiple interactions ISO Losartan inhibits the reaction [AGT protein alternative form results in increased expression of PDGFA mRNA alternative form] CTD PMID:12431451 NCBI chr 5:138,976,014...139,000,792
Ensembl chr 5:138,976,014...138,997,370
JBrowse link
G Pdgfb platelet derived growth factor, B polypeptide multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of PDGFB mRNA]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein] CTD PMID:12930639 PMID:17043664 NCBI chr15:79,995,865...80,024,614
Ensembl chr15:79,995,874...80,014,977
JBrowse link
G Pdgfd platelet-derived growth factor, D polypeptide multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of PDGFD mRNA] CTD PMID:17043664 NCBI chr 9:6,168,363...6,534,284
Ensembl chr 9:6,168,584...6,378,850
JBrowse link
G Pdgfrb platelet derived growth factor receptor, beta polypeptide multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of PDGFRB mRNA] CTD PMID:17043664 NCBI chr18:61,045,127...61,085,067
Ensembl chr18:61,045,150...61,085,061
JBrowse link
G Pdlim3 PDZ and LIM domain 3 decreases expression ISO Losartan results in decreased expression of PDLIM3 mRNA CTD PMID:15100363 NCBI chr 8:45,885,487...45,919,635
Ensembl chr 8:45,885,461...45,919,548
JBrowse link
G Pecam1 platelet/endothelial cell adhesion molecule 1 decreases expression EXP Losartan results in decreased expression of PECAM1 mRNA CTD PMID:19771429 NCBI chr11:106,654,213...106,715,281
Ensembl chr11:106,654,217...106,750,628
JBrowse link
G Plat plasminogen activator, tissue decreases expression ISO Losartan results in decreased expression of PLAT mRNA CTD PMID:15100363 NCBI chr 8:22,757,722...22,782,848
Ensembl chr 8:22,757,727...22,782,844
JBrowse link
G Podxl podocalyxin-like multiple interactions EXP Losartan inhibits the reaction [AGT protein results in decreased expression of PODXL protein] CTD PMID:28578904 NCBI chr 6:31,519,493...31,563,937
Ensembl chr 6:31,519,488...31,563,981
JBrowse link
G Postn periostin, osteoblast specific factor multiple interactions
decreases expression
ISO
EXP
Losartan inhibits the reaction [AGT protein results in increased expression of POSTN mRNA]
Losartan results in decreased expression of POSTN mRNA
CTD PMID:15121739 PMID:21641384 NCBI chr 3:54,359,267...54,391,041
Ensembl chr 3:54,361,109...54,391,037
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of PPARA mRNA] CTD PMID:19109942 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions ISO
EXP
Losartan inhibits the reaction [AGT protein results in increased expression of PPARG mRNA]
Losartan inhibits the reaction [[Dietary Fats co-treated with Cholesterol] results in increased expression of PPARG mRNA]
CTD PMID:18302760 PMID:19109942 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha multiple interactions
increases expression
ISO Losartan inhibits the reaction [AGT protein results in increased expression of PPARGC1A mRNA]
Losartan results in increased expression of PPARGC1A mRNA
CTD PMID:18765277 PMID:18971572 PMID:19109942 NCBI chr 5:51,454,249...52,115,853
Ensembl chr 5:51,454,250...51,567,726
JBrowse link
G Prkcb protein kinase C, beta multiple interactions ISO Losartan inhibits the reaction [Ethanol results in increased expression of PRKCB protein] CTD PMID:22497828 NCBI chr 7:122,289,104...122,634,402
Ensembl chr 7:122,288,751...122,634,402
JBrowse link
G Prl prolactin multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased secretion of PRL protein] CTD PMID:14722030 NCBI chr13:27,057,570...27,065,204
Ensembl chr13:27,057,570...27,065,205
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
ISO
EXP
Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [Phenylephrine results in increased expression of PTGS2 mRNA]; Losartan inhibits the reaction [Phenylephrine results in increased expression of PTGS2 protein]
Losartan inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]
Losartan results in decreased expression of PTGS2 mRNA; Losartan results in decreased expression of PTGS2 protein
CTD PMID:17244722 PMID:18267125 PMID:21377515 PMID:28578904 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Pth1r parathyroid hormone 1 receptor multiple interactions ISO Losartan inhibits the reaction [Folic Acid results in decreased expression of PTH1R protein]; Losartan inhibits the reaction [Gentamicins results in decreased expression of PTH1R protein] CTD PMID:15728788 NCBI chr 9:110,722,085...110,747,145
Ensembl chr 9:110,722,085...110,747,145
JBrowse link
G Pthlh parathyroid hormone-like peptide multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of PTHLH mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PTHLH protein]; Losartan inhibits the reaction [Folic Acid results in increased expression of PTHLH mRNA]; Losartan inhibits the reaction [Folic Acid results in increased expression of PTHLH protein]; Losartan inhibits the reaction [Gentamicins results in increased expression of PTHLH protein] CTD PMID:15728788 NCBI chr 6:147,252,109...147,264,013
Ensembl chr 6:147,252,101...147,264,183
JBrowse link
G Reg3g regenerating islet-derived 3 gamma multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of REG3G mRNA] CTD PMID:27798352 NCBI chr 6:78,466,269...78,468,874
Ensembl chr 6:78,466,269...78,468,872
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO
EXP
Losartan inhibits the reaction [Doxorubicin results in increased expression of RELA mRNA]
Losartan inhibits the reaction [AGT protein results in increased expression of RELA protein]; Losartan inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of RELA protein]
CTD PMID:15157388 PMID:28578904 PMID:29859236 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Ren1 renin 1 structural multiple interactions
increases expression
increases activity
ISO
EXP
[Losartan results in decreased activity of AGTR1 protein] which results in increased expression of REN protein; Losartan inhibits the reaction [AGT protein results in increased expression of REN protein]; Losartan promotes the reaction [Hydrochlorothiazide results in increased expression of REN protein]
Losartan inhibits the reaction [AGT protein results in increased expression of REN1 protein]
Losartan results in increased expression of REN mRNA; Losartan results in increased expression of REN protein
Losartan results in increased activity of REN protein
[Lisinopril co-treated with Losartan] results in increased expression of REN mRNA; Losartan inhibits the reaction [Ethanol results in increased activity of REN protein]; Losartan promotes the reaction [Isoproterenol results in increased expression of REN protein]
CTD PMID:1387008 PMID:7965263 PMID:8382237 PMID:8403307 PMID:9124547 PMID:9245700 PMID:9431853 PMID:9533614 PMID:11709406 PMID:12013499 PMID:12569265 PMID:16221218 PMID:22982071 PMID:28578904 NCBI chr 1:133,350,674...133,360,320
Ensembl chr 1:133,350,510...133,360,325
JBrowse link
G Runx2 runt related transcription factor 2 multiple interactions ISO Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 mRNA]; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 protein] CTD PMID:27412937 NCBI chr17:44,495,987...44,814,797
Ensembl chr17:44,495,987...44,814,797
JBrowse link
G S100a4 S100 calcium binding protein A4 multiple interactions ISO [Losartan co-treated with ICG 001] inhibits the reaction [AGT protein results in increased expression of S100A4 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of S100A4 protein] CTD PMID:28578904 NCBI chr 3:90,603,770...90,606,045
Ensembl chr 3:90,603,771...90,606,045
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 multiple interactions ISO Losartan inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 mRNA]; Losartan inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 protein] CTD PMID:29609002 NCBI chr 3:115,710,433...115,715,055
Ensembl chr 3:115,710,433...115,715,072
JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions EXP Losartan inhibits the reaction [[Dietary Fats co-treated with Cholesterol] results in decreased expression of SCARB1 mRNA] CTD PMID:18302760 NCBI chr 5:125,277,087...125,341,094
Ensembl chr 5:125,277,087...125,341,094
JBrowse link
G Sdc2 syndecan 2 decreases expression ISO Losartan results in decreased expression of SDC2 mRNA; Losartan results in decreased expression of SDC2 protein CTD PMID:15100363 NCBI chr15:32,920,723...33,034,721
Ensembl chr15:32,920,723...33,034,935
JBrowse link
G Selp selectin, platelet multiple interactions ISO Losartan inhibits the reaction [Estrogens deficiency results in increased expression of SELP protein] CTD PMID:19553526 NCBI chr 1:164,115,264...164,150,026
Ensembl chr 1:164,115,264...164,150,026
JBrowse link
G Sfrp2 secreted frizzled-related protein 2 decreases response to substance ISO SFRP2 protein results in decreased susceptibility to Losartan CTD PMID:23875703 NCBI chr 3:83,765,750...83,774,314
Ensembl chr 3:83,766,321...83,774,316
JBrowse link
G Slc22a12 solute carrier family 22 (organic anion/cation transporter), member 12 decreases activity
affects response to substance
decreases expression
multiple interactions
ISO Losartan results in decreased activity of SLC22A12 protein
SLC22A12 protein affects the susceptibility to Losartan
Losartan results in decreased expression of SLC22A12 mRNA
[Losartan results in decreased activity of SLC22A12 protein] which results in decreased abundance of Uric Acid
CTD PMID:18670416 PMID:20486468 NCBI chr19:6,535,854...6,543,070
Ensembl chr19:6,535,845...6,543,032
JBrowse link
G Slc22a19 solute carrier family 22 (organic anion transporter), member 19 multiple interactions ISO Losartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate] CTD PMID:17132213 NCBI chr19:7,673,075...7,711,310
Ensembl chr19:7,673,061...7,711,310
JBrowse link
G Slc2a9 solute carrier family 2 (facilitated glucose transporter), member 9 multiple interactions EXP Losartan inhibits the reaction [SLC2A9 protein results in increased uptake of Uric Acid] CTD PMID:19587147 NCBI chr 5:38,349,272...38,503,147
Ensembl chr 5:38,349,273...38,503,143
JBrowse link
G Slc9a3 solute carrier family 9 (sodium/hydrogen exchanger), member 3 multiple interactions EXP Losartan inhibits the reaction [Ammonium Chloride results in increased expression of NHE3 protein] CTD PMID:18287403 NCBI chr13:74,086,255...74,169,442
Ensembl chr13:74,121,457...74,169,442
JBrowse link
G Snai1 snail family zinc finger 1 multiple interactions ISO ICG 001 promotes the reaction [Losartan inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]]; Losartan inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]] CTD PMID:28578904 NCBI chr 2:167,538,195...167,542,814
Ensembl chr 2:167,538,195...167,542,814
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial decreases activity ISO Losartan results in decreased activity of SOD2 protein CTD PMID:18765277 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
G Sod3 superoxide dismutase 3, extracellular multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of SOD3 protein] CTD PMID:10400907 NCBI chr 5:52,363,804...52,369,738
Ensembl chr 5:52,363,791...52,371,418
JBrowse link
G Sparc secreted acidic cysteine rich glycoprotein decreases expression ISO Losartan results in decreased expression of SPARC mRNA CTD PMID:15100363 NCBI chr11:55,394,159...55,420,080
Ensembl chr11:55,394,500...55,423,183
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of SREBF1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of SREBF1 protein] CTD PMID:19109942 PMID:25398788 NCBI chr11:60,199,084...60,224,186
Ensembl chr11:60,199,089...60,222,581
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO
EXP
Losartan results in decreased phosphorylation of STAT3 protein CTD PMID:33380422 NCBI chr11:100,886,806...100,939,594
Ensembl chr11:100,885,098...100,939,540
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases secretion
multiple interactions
decreases activity
decreases expression
increases expression
ISO
EXP
Losartan results in decreased secretion of TGFB1 protein
Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of TGFB1 protein]
[Losartan results in decreased activity of AGT protein] which results in decreased activity of TGFB1 protein
Losartan results in decreased expression of TGFB1 mRNA; Losartan results in decreased expression of TGFB1 protein
Losartan results in increased expression of TGFB1 protein
[Losartan co-treated with Cilazapril] inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; [Losartan co-treated with Nifedipine] results in decreased expression of TGFB1 mRNA; Losartan inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased secretion of TGFB1 protein]; Losartan inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; Losartan inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]
CTD PMID:11369837 PMID:12930639 PMID:12937228 PMID:15331931 PMID:15573910 PMID:16191423 PMID:17330452 PMID:17666919 PMID:17784886 PMID:21152098 PMID:25233898 PMID:29859236 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 multiple interactions
decreases expression
ISO Losartan inhibits the reaction [Paraquat results in increased expression of TIMP1 mRNA]; Losartan inhibits the reaction [Simvastatin results in decreased expression of TIMP1 mRNA]; Simvastatin inhibits the reaction [Losartan results in decreased expression of TIMP1 mRNA] CTD PMID:20137537 PMID:25233898 NCBI chr  X:20,870,166...20,874,737
Ensembl chr  X:20,870,166...20,874,735
JBrowse link
G Timp2 tissue inhibitor of metalloproteinase 2 decreases expression
multiple interactions
ISO Losartan results in decreased expression of TIMP2 mRNA
Losartan inhibits the reaction [Simvastatin results in decreased expression of TIMP2 mRNA]; Simvastatin inhibits the reaction [Losartan results in decreased expression of TIMP2 mRNA]
CTD PMID:20137537 NCBI chr11:118,301,061...118,355,411
Ensembl chr11:118,301,069...118,355,740
JBrowse link
G Tjp1 tight junction protein 1 decreases expression ISO Losartan results in decreased expression of TJP1 protein CTD PMID:18400868 NCBI chr 7:65,296,165...65,527,850
Ensembl chr 7:65,296,165...65,527,781
JBrowse link
G Tnc tenascin C decreases expression ISO Losartan results in decreased expression of TNC mRNA CTD PMID:15100363 NCBI chr 4:63,959,785...64,047,015
Ensembl chr 4:63,959,785...64,047,015
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
Losartan affects the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Losartan inhibits the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]; Losartan inhibits the reaction [AGT protein modified form promotes the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]]; Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Losartan inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Losartan inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; T 0070907 inhibits the reaction [Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]
Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of TNF protein]
Losartan results in decreased expression of TNF protein
Losartan inhibits the reaction [bisphenol A results in increased expression of TNF mRNA]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased secretion of TNF protein]
CTD PMID:15573910 PMID:17299153 PMID:18060435 PMID:22124178 PMID:23875703 PMID:29859236 PMID:30677511 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tomm20 translocase of outer mitochondrial membrane 20 decreases expression ISO Losartan results in decreased expression of TOMM20 mRNA CTD PMID:18765277 NCBI chr 8:126,930,664...126,945,921
Ensembl chr 8:126,930,667...126,945,844
JBrowse link
G Trp53 transformation related protein 53 affects expression ISO Losartan affects the expression of TP53 protein CTD PMID:22000973 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Tsc22d1 TSC22 domain family, member 1 multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of TSC22D1 mRNA] CTD PMID:26464165 NCBI chr14:76,414,961...76,507,765
Ensembl chr14:76,414,961...76,507,765
JBrowse link
G Twist1 twist basic helix-loop-helix transcription factor 1 multiple interactions ISO
EXP
Losartan inhibits the reaction [AGT protein results in increased expression of TWIST1 protein] CTD PMID:28578904 NCBI chr12:33,957,671...33,959,831
Ensembl chr12:33,957,671...33,959,829
JBrowse link
G Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) decreases expression
multiple interactions
EXP
ISO
Losartan results in decreased expression of UCP2 mRNA; Losartan results in decreased expression of UCP2 protein
Losartan inhibits the reaction [AGT protein results in increased expression of UCP2 mRNA]
CTD PMID:17508912 PMID:19109942 NCBI chr 7:100,493,337...100,499,629
Ensembl chr 7:100,493,337...100,502,020
JBrowse link
G Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of UCP3 mRNA] CTD PMID:19109942 NCBI chr 7:100,472,991...100,486,432
Ensembl chr 7:100,472,990...100,486,432
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Losartan inhibits the reaction [Estrogens deficiency results in increased expression of VCAM1 protein] CTD PMID:19553526 NCBI chr 3:116,110,020...116,129,688
Ensembl chr 3:116,109,949...116,129,688
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression
ISO
EXP
Losartan inhibits the reaction [IL1A protein results in increased expression of VEGFA mRNA]; Losartan inhibits the reaction [IL1A protein results in increased expression of VEGFA protein]; Losartan inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Losartan inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; Losartan promotes the reaction [AGT protein results in increased expression of VEGFA mRNA]; Losartan promotes the reaction [AGT protein results in increased secretion of VEGFA protein]
Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of VEGFA protein]; Losartan inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]
Losartan inhibits the reaction [Cyclosporine results in increased expression of VEGFA protein]
Losartan results in decreased expression of VEGFA mRNA; Losartan results in decreased expression of VEGFA protein
CTD PMID:12110003 PMID:17299153 PMID:17481528 PMID:22188725 PMID:25511041 PMID:29859236 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link
G Vegfc vascular endothelial growth factor C decreases expression EXP Losartan results in decreased expression of VEGFC mRNA CTD PMID:19771429 NCBI chr 8:54,077,532...54,186,454
Ensembl chr 8:54,077,606...54,187,096
JBrowse link
G Vim vimentin multiple interactions ISO
EXP
Losartan inhibits the reaction [AGT protein results in increased expression of VIM protein]
Losartan inhibits the reaction [AGT protein results in increased expression of VIM protein]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein]
CTD PMID:28578904 PMID:33007385 NCBI chr 2:13,574,311...13,582,826
Ensembl chr 2:13,573,927...13,582,826
JBrowse link
G Wnt1 wingless-type MMTV integration site family, member 1 multiple interactions EXP
ISO
Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 protein] CTD PMID:28578904 NCBI chr15:98,789,857...98,793,830
Ensembl chr15:98,789,857...98,793,837
JBrowse link
G Wt1 Wilms tumor 1 homolog multiple interactions EXP Losartan inhibits the reaction [AGT protein results in decreased expression of WT1 protein] CTD PMID:28578904 NCBI chr 2:105,126,529...105,173,614
Ensembl chr 2:105,126,529...105,173,616
JBrowse link
losartan carboxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a19 solute carrier family 22 (organic anion transporter), member 19 multiple interactions ISO losartan carboxylic acid inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate] CTD PMID:17132213 NCBI chr19:7,673,075...7,711,310
Ensembl chr19:7,673,061...7,711,310
JBrowse link
macitentan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A decreases expression ISO macitentan results in decreased expression of ABCB1 mRNA CTD PMID:28369585 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 decreases expression ISO macitentan results in decreased expression of ABCC2 mRNA CTD PMID:28369585 NCBI chr19:43,782,308...43,838,332
Ensembl chr19:43,782,192...43,840,740
JBrowse link
G Abcc3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 decreases expression ISO macitentan results in decreased expression of ABCC3 mRNA CTD PMID:28369585 NCBI chr11:94,343,295...94,393,017
Ensembl chr11:94,343,295...94,392,997
JBrowse link
G Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 decreases expression ISO macitentan results in decreased expression of SLC10A1 mRNA CTD PMID:28369585 NCBI chr12:80,953,185...80,968,705
Ensembl chr12:80,953,183...80,968,705
JBrowse link
PD123319 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 multiple interactions ISO PD 123319 inhibits the reaction [diminazene aceturate results in increased expression of ACE2 protein] CTD PMID:28688122 NCBI chr  X:164,139,342...164,188,418
Ensembl chr  X:164,139,332...164,188,420
JBrowse link
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) multiple interactions
decreases response to substance
decreases activity
ISO
EXP
[olmesartan co-treated with PD 123319] inhibits the reaction [AGT protein modified form results in increased abundance of Fatty Acids, Nonesterified]; [olmesartan co-treated with PD 123319] inhibits the reaction [AGT protein modified form results in increased secretion of and results in increased abundance of Triglycerides]; PD 123319 inhibits the reaction [AGT protein results in increased expression of MDM2 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of MDM2 protein]
PD 123319 results in decreased susceptibility to AGT protein
PD 123319 results in decreased activity of AGT protein modified form
PD 123319 affects the reaction [AGT protein promotes the reaction [PTPN6 protein binds to MTUS1 protein]]; PD 123319 inhibits the reaction [AGT protein results in increased abundance of Nitric Oxide]; PD 123319 inhibits the reaction [AGT protein results in increased expression of ANGPT1 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of ANGPT2 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of EDN1 protein]; PD 123319 inhibits the reaction [AGT protein results in increased expression of KDR mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of MAP2 protein]; PD 123319 inhibits the reaction [AGT protein results in increased expression of SPP1 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of SPP1 protein]; PD 123319 inhibits the reaction [AGT protein results in increased expression of TEK mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of TUBB3 protein]; PD 123319 inhibits the reaction [AGT protein results in increased expression of UBE2V2 protein]; PD 123319 inhibits the reaction [AGT protein results in increased expression of VEGFA mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of VEGFA protein]; PD 123319 promotes the reaction [AGT protein results in increased abundance of Prostaglandins E]
PD 123319 inhibits the reaction [AGT protein results in increased expression of UBE2V2 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of UBE2V2 protein]; PD 123319 inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; PD 123319 inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 protein]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX2 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX2 protein]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX4 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP mRNA]]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP protein]]]; PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [[AGT protein co-treated with Rotenone] results in increased expression of AGTR2 protein]]; PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTR2 mRNA]]]
CTD PMID:9176287 PMID:9519251 PMID:11115077 PMID:14597853 PMID:14638905 PMID:14718351 PMID:15007106 PMID:16003179 PMID:16769992 PMID:17068200 PMID:18206046 PMID:18300857 PMID:19041135 PMID:19246637 PMID:25446015 NCBI chr 8:124,556,587...124,569,706
Ensembl chr 8:124,556,534...124,569,706
JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions
decreases activity
increases expression
decreases expression
ISO
EXP
[PD 123319 binds to and results in decreased activity of AGTR2 protein] inhibits the reaction [candesartan results in increased expression of NOS3 protein]; PD 123319 binds to and results in decreased activity of AGTR2 protein
PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [[AGT protein co-treated with Rotenone] results in increased expression of AGTR2 protein]]; PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTR2 mRNA]]]
PD 123319 results in decreased activity of AGTR2 protein
PD 123319 results in increased expression of AGTR2 mRNA; PD 123319 results in increased expression of AGTR2 protein
PD 123319 results in decreased expression of AGTR2 mRNA
[PD 123319 binds to and results in decreased activity of AGTR2 protein] which affects the susceptibility to Phenylephrine; [PD 123319 results in decreased activity of AGTR2 protein] inhibits the reaction [Valsartan results in increased abundance of Cyclic GMP]; [PD 123319 results in decreased activity of AGTR2 protein] which results in decreased susceptibility to Estradiol; [PD 123319 results in decreased activity of AGTR2 protein] which results in decreased susceptibility to Valsartan; PD 123319 binds to and results in decreased activity of AGTR2 protein
CTD PMID:9336375 PMID:9740612 PMID:11509473 PMID:11893553 PMID:15807884 PMID:16982965 PMID:18300857 PMID:18388195 PMID:18551021 PMID:19151255 PMID:25446015 NCBI chr  X:21,484,624...21,488,833
Ensembl chr  X:21,484,544...21,489,164
JBrowse link
G Agtrap angiotensin II, type I receptor-associated protein multiple interactions EXP PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP mRNA]]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP protein]]] CTD PMID:25446015 NCBI chr 4:148,077,061...148,088,064
Ensembl chr 4:148,077,061...148,088,031
JBrowse link
G Angpt1 angiopoietin 1 multiple interactions ISO PD 123319 inhibits the reaction [AGT protein results in increased expression of ANGPT1 mRNA] CTD PMID:14638905 NCBI chr15:42,424,667...42,676,977
Ensembl chr15:42,424,723...42,676,977
JBrowse link
G Angpt2 angiopoietin 2 multiple interactions ISO PD 123319 inhibits the reaction [AGT protein results in increased expression of ANGPT2 mRNA] CTD PMID:14638905 NCBI chr 8:18,690,263...18,741,562
Ensembl chr 8:18,690,263...18,741,562
JBrowse link
G Bdkrb2 bradykinin receptor, beta 2 multiple interactions EXP PD 123319 affects the reaction [BDKRB2 affects the abundance of 6-Ketoprostaglandin F1 alpha] CTD PMID:16514058 NCBI chr12:105,563,172...105,595,244
Ensembl chr12:105,563,226...105,595,237
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 multiple interactions ISO PD 123319 inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA] CTD PMID:15284299 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Ccl5 chemokine (C-C motif) ligand 5 multiple interactions ISO PD 123319 inhibits the reaction [Ethylene Glycol results in increased expression of CCL5 protein] CTD PMID:16284884 NCBI chr11:83,525,778...83,530,518
Ensembl chr11:83,525,778...83,530,518
JBrowse link
G Cybb cytochrome b-245, beta polypeptide multiple interactions EXP PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX2 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX2 protein]] CTD PMID:25446015 NCBI chr  X:9,435,252...9,487,766
Ensembl chr  X:9,435,252...9,487,771
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO PD 123319 inhibits the reaction [AGT protein results in increased expression of EDN1 protein] CTD PMID:15007106 NCBI chr13:42,301,476...42,307,990
Ensembl chr13:42,301,476...42,307,990
JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO PD123319 co-treated with losartan inhibits the reaction [Angiotensin II increases phosphorylation of JAK2 protein in liver] RGD PMID:22613986 RGD:127285667 NCBI chr19:29,251,803...29,313,095
Ensembl chr19:29,251,828...29,313,080
JBrowse link
G Kdr kinase insert domain protein receptor multiple interactions ISO PD 123319 inhibits the reaction [AGT protein results in increased expression of KDR mRNA] CTD PMID:14638905 NCBI chr 5:75,932,827...75,979,072
Ensembl chr 5:75,932,827...75,978,458
JBrowse link
G Kng2 kininogen 2 multiple interactions EXP
ISO
PD 123319 affects the reaction [KNG1 affects the abundance of Nitric Oxide]
PD 123319 inhibits the reaction [benazepril promotes the reaction [Valsartan results in increased expression of KNG1 protein modified form]]; PD 123319 inhibits the reaction [Valsartan promotes the reaction [benazepril results in increased expression of KNG1 protein modified form]]
CTD PMID:11509473 PMID:16514058 NCBI chr16:22,985,852...23,029,101
Ensembl chr16:22,985,854...23,029,482
JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions ISO PD 123319 inhibits the reaction [AGT protein results in increased expression of MAP2 protein] CTD PMID:17068200 NCBI chr 1:66,175,202...66,442,583
Ensembl chr 1:66,175,273...66,442,583
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions EXP PD 123319 inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein] CTD PMID:19041135 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions EXP PD 123319 inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein] CTD PMID:19041135 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 multiple interactions ISO PD 123319 inhibits the reaction [AGT protein results in increased expression of MDM2 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of MDM2 protein] CTD PMID:18206046 NCBI chr10:117,688,875...117,710,758
Ensembl chr10:117,688,875...117,710,758
JBrowse link
G Mtus1 mitochondrial tumor suppressor 1 multiple interactions ISO PD 123319 affects the reaction [AGT protein promotes the reaction [PTPN6 protein binds to MTUS1 protein]] CTD PMID:17068200 NCBI chr 8:40,990,912...41,133,983
Ensembl chr 8:40,990,914...41,133,726
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO PD 123319 inhibits the reaction [Ethylene Glycol results in increased expression of NFKB1 protein] CTD PMID:16284884 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547
JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell multiple interactions ISO [PD 123319 binds to and results in decreased activity of AGTR2 protein] inhibits the reaction [candesartan results in increased expression of NOS3 protein] CTD PMID:18551021 NCBI chr 5:24,364,816...24,384,474
Ensembl chr 5:24,364,810...24,384,474
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 protein]] CTD PMID:25446015 NCBI chr  X:134,086,421...134,137,711
Ensembl chr  X:134,086,421...134,221,956
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions EXP PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX4 mRNA]] CTD PMID:25446015 NCBI chr 7:87,244,430...87,398,710
Ensembl chr 7:87,246,096...87,398,710
JBrowse link
G Prkce protein kinase C, epsilon increases expression ISO PD 123319 results in increased expression of PRKCE protein CTD PMID:11893553 NCBI chr17:86,167,785...86,657,919
Ensembl chr17:86,167,785...86,657,919
JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 multiple interactions ISO PD 123319 affects the reaction [AGT protein promotes the reaction [PTPN6 protein binds to MTUS1 protein]] CTD PMID:17068200 NCBI chr 6:124,720,707...124,738,709
Ensembl chr 6:124,720,707...124,738,714
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO PD 123319 inhibits the reaction [AGT protein results in increased expression of SPP1 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of SPP1 protein] CTD PMID:11115077 NCBI chr 5:104,435,111...104,441,053
Ensembl chr 5:104,435,118...104,441,050
JBrowse link
G Tek TEK receptor tyrosine kinase multiple interactions ISO PD 123319 inhibits the reaction [AGT protein results in increased expression of TEK mRNA] CTD PMID:14638905 NCBI chr 4:94,739,086...94,874,976
Ensembl chr 4:94,739,289...94,874,976
JBrowse link
G Tubb3 tubulin, beta 3 class III multiple interactions ISO PD 123319 inhibits the reaction [AGT protein results in increased expression of TUBB3 protein] CTD PMID:17068200 NCBI chr 8:123,411,553...123,422,015
Ensembl chr 8:123,411,424...123,422,015
JBrowse link
G Ube2v2 ubiquitin-conjugating enzyme E2 variant 2 multiple interactions EXP
ISO
PD 123319 inhibits the reaction [AGT protein results in increased expression of UBE2V2 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of UBE2V2 protein] CTD PMID:16769992 PMID:17068200 NCBI chr16:15,550,986...15,594,518
Ensembl chr16:15,552,077...15,595,773
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO PD 123319 inhibits the reaction [AGT protein results in increased expression of VEGFA mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of VEGFA protein]; PD 123319 inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]; PD 123319 inhibits the reaction [Streptozocin results in increased expression of VEGFA protein] CTD PMID:14638905 PMID:14718351 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21747
    role 21725
      biological role 21723
        pharmacological role 19377
          antagonist 16465
            hormone antagonist 11343
              endothelin receptor antagonist 256
                ACT-132577 + 4
                PD123319 30
                bosentan + 88
                endothelin A receptor antagonist 0
                enrasentan 2
                losartan + 170
                macitentan 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 21747
    role 21725
      application 21234
        pharmaceutical 20716
          drug 20716
            receptor modulator 19442
              hormone receptor modulator 19402
                hormone antagonist 11343
                  endothelin receptor antagonist 256
                    ACT-132577 + 4
                    PD123319 30
                    bosentan + 88
                    endothelin A receptor antagonist 0
                    enrasentan 2
                    losartan + 170
                    macitentan 4
paths to the root