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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:endothelin receptor antagonist
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Accession:CHEBI:51451 term browser browse the term
Definition:A hormone antagonist that blocks endothelin receptors.
Synonyms:related_synonym: ERA


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bosentan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 decreases expression EXP bosentan results in decreased expression of ABCB1 mRNA CTD PMID:28369585 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ABCB11 ATP binding cassette subfamily B member 11 decreases activity
decreases expression
multiple interactions
ISO
EXP
bosentan metabolite results in decreased activity of ABCB11 protein; bosentan results in decreased activity of ABCB11 protein
Bosentan results in decreased expression of ABCB11 mRNA
bosentan results in decreased expression of ABCB11 mRNA
bosentan inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:11309550 PMID:15465654 PMID:15509663 PMID:20829430 PMID:23956101 PMID:24014644 PMID:27765674 PMID:29761207 NCBI chr 2:168,915,468...169,031,396
Ensembl chr 2:168,915,498...169,031,324
JBrowse link
G ABCB4 ATP binding cassette subfamily B member 4 decreases expression EXP Bosentan results in decreased expression of ABCB4 mRNA CTD PMID:29761207 NCBI chr 7:87,398,988...87,476,722
Ensembl chr 7:87,401,696...87,480,435
JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 increases expression
decreases expression
ISO
EXP
bosentan results in increased expression of ABCC2 mRNA
Bosentan results in increased expression of ABCC2 mRNA
bosentan results in decreased expression of ABCC2 mRNA
CTD PMID:27765674 PMID:28369585 PMID:29761207 NCBI chr10:99,782,602...99,853,741
Ensembl chr10:99,782,640...99,852,594
JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 increases expression
decreases expression
ISO
EXP
bosentan results in increased expression of ABCC3 mRNA
bosentan results in decreased expression of ABCC3 mRNA
CTD PMID:27765674 PMID:28369585 NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253
JBrowse link
G ABCC4 ATP binding cassette subfamily C member 4 increases expression ISO bosentan results in increased expression of ABCC4 mRNA CTD PMID:27765674 NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475
JBrowse link
G ABCG5 ATP binding cassette subfamily G member 5 increases expression
affects expression
ISO
EXP
bosentan results in increased expression of ABCG5 mRNA
Bosentan affects the expression of ABCG5 mRNA
CTD PMID:27765674 PMID:29761207 NCBI chr 2:43,806,154...43,838,840
Ensembl chr 2:43,812,472...43,838,865
JBrowse link
G ABCG8 ATP binding cassette subfamily G member 8 increases expression ISO bosentan results in increased expression of ABCG8 mRNA CTD PMID:27765674 NCBI chr 2:43,831,942...43,882,988
Ensembl chr 2:43,831,942...43,882,988
JBrowse link
G ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide decreases expression EXP Bosentan results in decreased expression of ADH1A mRNA; Bosentan results in decreased expression of ADH1A protein CTD PMID:29761207 NCBI chr 4:99,276,369...99,290,985
Ensembl chr 4:99,276,369...99,291,003
JBrowse link
G ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide decreases expression EXP Bosentan results in decreased expression of ADH1B mRNA; Bosentan results in decreased expression of ADH1B protein CTD PMID:29761207 NCBI chr 4:99,304,971...99,321,401
Ensembl chr 4:99,304,971...99,352,760
JBrowse link
G ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide decreases expression EXP Bosentan results in decreased expression of ADH1C mRNA; Bosentan results in decreased expression of ADH1C protein CTD PMID:29761207 NCBI chr 4:99,336,497...99,352,746
Ensembl chr 4:99,336,497...99,352,746
JBrowse link
G ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide decreases expression EXP Bosentan results in decreased expression of ADH4 mRNA; Bosentan results in decreased expression of ADH4 protein CTD PMID:29761207 NCBI chr 4:99,123,658...99,144,297
Ensembl chr 4:99,123,657...99,157,792
JBrowse link
G ADRB2 adrenoceptor beta 2 multiple interactions EXP bosentan inhibits the reaction [EDN1 protein results in increased expression of ADRB2 mRNA] CTD PMID:22483689 NCBI chr 5:148,826,611...148,828,623
Ensembl chr 5:148,826,611...148,828,623
JBrowse link
G ALDH8A1 aldehyde dehydrogenase 8 family member A1 affects expression EXP Bosentan affects the expression of ALDH8A1 mRNA CTD PMID:29761207 NCBI chr 6:134,917,393...134,950,101
Ensembl chr 6:134,917,393...134,950,115
JBrowse link
G ALDOB aldolase, fructose-bisphosphate B decreases expression EXP Bosentan results in decreased expression of ALDOB mRNA; Bosentan results in decreased expression of ALDOB protein CTD PMID:29761207 NCBI chr 9:101,420,560...101,435,774
Ensembl chr 9:101,420,560...101,449,664
JBrowse link
G ASCL1 achaete-scute family bHLH transcription factor 1 affects expression EXP Bosentan affects the expression of ASCL1 mRNA CTD PMID:29761207 NCBI chr12:102,957,674...102,960,513
Ensembl chr12:102,957,674...102,960,513
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO bosentan inhibits the reaction [Doxorubicin results in increased expression of BAX protein] CTD PMID:17974986 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G C15orf48 chromosome 15 open reading frame 48 affects expression EXP Bosentan affects the expression of C15ORF48 mRNA CTD PMID:29761207 NCBI chr15:45,430,610...45,433,340
Ensembl chr15:45,430,579...45,448,761
JBrowse link
G C9 complement C9 affects expression EXP Bosentan affects the expression of C9 mRNA CTD PMID:29761207 NCBI chr 5:39,284,140...39,364,495
Ensembl chr 5:39,284,140...39,424,868
JBrowse link
G CA12 carbonic anhydrase 12 affects expression EXP Bosentan affects the expression of CA12 mRNA CTD PMID:29761207 NCBI chr15:63,321,378...63,381,846
Ensembl chr15:63,321,378...63,381,846
JBrowse link
G CAT catalase decreases expression EXP Bosentan results in decreased expression of CAT mRNA CTD PMID:29761207 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CFHR3 complement factor H related 3 affects expression EXP Bosentan affects the expression of CFHR3 mRNA CTD PMID:29761207 NCBI chr 1:196,774,816...196,795,407
Ensembl chr 1:196,774,813...196,795,407
JBrowse link
G COL1A2 collagen type I alpha 2 chain decreases expression ISO bosentan results in decreased expression of COL1A2 protein CTD PMID:11729239 NCBI chr 7:94,394,895...94,431,227
Ensembl chr 7:94,394,895...94,431,227
JBrowse link
G CPS1 carbamoyl-phosphate synthase 1 decreases expression EXP Bosentan results in decreased expression of CPS1 mRNA; Bosentan results in decreased expression of CPS1 protein CTD PMID:29761207 NCBI chr 2:210,477,685...210,679,107
Ensembl chr 2:210,477,682...210,679,107
JBrowse link
G CXADR CXADR Ig-like cell adhesion molecule decreases expression
multiple interactions
EXP bosentan results in decreased expression of CXADR mRNA; bosentan results in decreased expression of CXADR protein
EDN1 protein inhibits the reaction [bosentan results in decreased expression of CXADR mRNA]
CTD PMID:20392896 NCBI chr21:17,513,016...17,636,213
Ensembl chr21:17,513,043...17,593,579
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression EXP Bosentan results in increased expression of CXCL8 mRNA CTD PMID:29761207 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 increases expression EXP Bosentan results in increased expression of CYP2B6 mRNA CTD PMID:18332078 PMID:29761207 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases expression EXP Bosentan results in increased expression of CYP3A4 mRNA CTD PMID:18332078 PMID:29761207 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G CYP3A43 cytochrome P450 family 3 subfamily A member 43 affects expression EXP Bosentan affects the expression of CYP3A43 mRNA CTD PMID:29761207 NCBI chr 7:99,827,626...99,867,138
Ensembl chr 7:99,828,013...99,866,102
JBrowse link
G CYP3A7 cytochrome P450 family 3 subfamily A member 7 affects expression EXP Bosentan affects the expression of CYP3A7 mRNA CTD PMID:29761207 NCBI chr 7:99,705,036...99,735,196
Ensembl chr 7:99,705,036...99,735,196
JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 decreases expression EXP Bosentan results in decreased expression of CYP7A1 mRNA CTD PMID:29761207 NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163
JBrowse link
G DCLK1 doublecortin like kinase 1 affects expression EXP Bosentan affects the expression of DCLK1 mRNA CTD PMID:29761207 NCBI chr13:35,768,652...36,131,939
Ensembl chr13:35,768,652...36,131,382
JBrowse link
G DLX6 distal-less homeobox 6 decreases expression ISO bosentan results in decreased expression of DLX6 mRNA CTD PMID:15063187 NCBI chr 7:97,005,553...97,011,040
Ensembl chr 7:97,005,553...97,011,040
JBrowse link
G EDN1 endothelin 1 decreases activity
decreases expression
multiple interactions
ISO
EXP
bosentan results in decreased activity of EDN1 protein
bosentan results in decreased expression of EDN1 protein
bosentan inhibits the reaction [EDN1 protein results in increased expression of ADRB2 mRNA]; bosentan inhibits the reaction [Oxotremorine results in increased activity of EDN1 protein]; bosentan inhibits the reaction [TGFB1 protein results in increased activity of EDN1 protein]; EDN1 protein inhibits the reaction [bosentan results in decreased expression of CXADR mRNA]
3,5-dibromosalicylic acid inhibits the reaction [bosentan inhibits the reaction [EDN1 protein binds to EDNRA protein]]; bosentan binds to and results in decreased activity of EDN1 protein; bosentan inhibits the reaction [EDN1 protein binds to EDNRA protein]; bosentan inhibits the reaction [Monocrotaline results in increased expression of EDN1 mRNA]
CTD PMID:10474778 PMID:10961375 PMID:11093786 PMID:16431896 PMID:20392896 PMID:20967148 PMID:22483689 PMID:22796455 NCBI chr 6:12,256,463...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G EDN3 endothelin 3 decreases activity ISO bosentan results in decreased activity of EDN3 protein CTD PMID:10961375 NCBI chr20:59,300,415...59,325,992
Ensembl chr20:59,300,443...59,325,992
JBrowse link
G EDNRA endothelin receptor type A multiple interactions EXP
ISO
bosentan binds to and results in decreased activity of EDNRA protein
3,5-dibromosalicylic acid inhibits the reaction [bosentan inhibits the reaction [EDN1 protein binds to EDNRA protein]]; bosentan binds to and results in decreased activity of EDNRA protein; bosentan inhibits the reaction [EDN1 protein binds to EDNRA protein]
CTD PMID:11093786 PMID:15964565 PMID:16219361 NCBI chr 4:147,481,097...147,544,954
Ensembl chr 4:147,480,917...147,544,954
JBrowse link
G EDNRB endothelin receptor type B multiple interactions EXP bosentan binds to and results in decreased activity of EDNRB protein CTD PMID:16219361 NCBI chr13:77,895,481...77,975,527
Ensembl chr13:77,895,481...77,975,529
JBrowse link
G FABP1 fatty acid binding protein 1 decreases expression EXP Bosentan results in decreased expression of FABP1 mRNA; Bosentan results in decreased expression of FABP1 protein CTD PMID:29761207 NCBI chr 2:88,122,982...88,128,062
Ensembl chr 2:88,122,982...88,128,062
JBrowse link
G FN1 fibronectin 1 multiple interactions EXP Bosentan inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; Bosentan inhibits the reaction [Glucose results in increased expression of FN1 protein] CTD PMID:12388107 NCBI chr 2:215,360,862...215,436,167
Ensembl chr 2:215,360,440...215,436,073
JBrowse link
G G0S2 G0/G1 switch 2 affects expression EXP Bosentan affects the expression of G0S2 mRNA CTD PMID:29761207 NCBI chr 1:209,675,412...209,676,390
Ensembl chr 1:209,675,412...209,676,390
JBrowse link
G G6PC1 glucose-6-phosphatase catalytic subunit 1 affects expression EXP Bosentan affects the expression of G6PC1 mRNA CTD PMID:29761207 NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438
JBrowse link
G GATA4 GATA binding protein 4 multiple interactions
affects activity
ISO bosentan inhibits the reaction [Doxorubicin results in decreased expression of GATA4 mRNA]; bosentan inhibits the reaction [Doxorubicin results in decreased expression of GATA4 protein]
bosentan affects the activity of GATA4 protein
CTD PMID:17974986 PMID:21084678 NCBI chr 8:11,676,935...11,760,002
Ensembl chr 8:11,676,959...11,760,002
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases expression EXP Bosentan results in increased expression of GCLC mRNA CTD PMID:29761207 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GPX1 glutathione peroxidase 1 decreases expression EXP Bosentan results in decreased expression of GPX1 mRNA CTD PMID:29761207 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,176...49,358,353
JBrowse link
G GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) decreases expression EXP Bosentan results in decreased expression of GSTT2 mRNA CTD PMID:29761207 NCBI chr22:23,980,134...23,983,915
Ensembl chr22:23,980,058...23,983,915
JBrowse link
G HMOX1 heme oxygenase 1 increases expression EXP Bosentan results in increased expression of HMOX1 mRNA CTD PMID:29761207 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G HNF4A hepatocyte nuclear factor 4 alpha decreases expression EXP Bosentan results in decreased expression of HNF4A mRNA CTD PMID:29761207 NCBI chr20:44,355,699...44,434,596
Ensembl chr20:44,355,700...44,434,596
JBrowse link
G HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 affects expression EXP Bosentan affects the expression of HSD3B1 mRNA CTD PMID:29761207 NCBI chr 1:119,507,203...119,515,058
Ensembl chr 1:119,507,198...119,515,054
JBrowse link
G IGF1 insulin like growth factor 1 affects expression EXP Bosentan affects the expression of IGF1 mRNA CTD PMID:29761207 NCBI chr12:102,395,860...102,481,839
Ensembl chr12:102,395,874...102,481,744
JBrowse link
G IL6 interleukin 6 increases expression EXP Bosentan results in increased expression of IL6 mRNA CTD PMID:29761207 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G INHBE inhibin subunit beta E affects expression EXP Bosentan affects the expression of INHBE mRNA CTD PMID:29761207 NCBI chr12:57,455,307...57,458,025
Ensembl chr12:57,452,323...57,459,280
JBrowse link
G KMO kynurenine 3-monooxygenase affects expression EXP Bosentan affects the expression of KMO mRNA CTD PMID:29761207 NCBI chr 1:241,531,883...241,595,642
Ensembl chr 1:241,532,134...241,595,642
JBrowse link
G LEAP2 liver enriched antimicrobial peptide 2 affects expression EXP Bosentan affects the expression of LEAP2 mRNA CTD PMID:29761207 NCBI chr 5:132,873,668...132,875,046
Ensembl chr 5:132,873,444...132,875,046
JBrowse link
G MGST1 microsomal glutathione S-transferase 1 decreases expression EXP Bosentan results in decreased expression of MGST1 mRNA CTD PMID:29761207 NCBI chr12:16,347,115...16,377,192
Ensembl chr12:16,347,142...16,609,259
JBrowse link
G MRC1 mannose receptor C-type 1 affects expression EXP Bosentan affects the expression of MRC1 mRNA CTD PMID:29761207 NCBI chr10:17,809,348...17,911,164
Ensembl chr10:17,809,348...17,911,164
JBrowse link
G MT1X metallothionein 1X increases expression EXP Bosentan results in increased expression of MT1X mRNA CTD PMID:29761207 NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196
JBrowse link
G MTTP microsomal triglyceride transfer protein decreases expression EXP Bosentan results in decreased expression of MTTP mRNA CTD PMID:29761207 NCBI chr 4:99,564,130...99,623,997
Ensembl chr 4:99,564,081...99,623,997
JBrowse link
G MYH7 myosin heavy chain 7 multiple interactions EXP Bosentan inhibits the reaction [MYH7 gene mutant form results in increased expression of NPPB protein] CTD PMID:29741611 NCBI chr14:23,412,740...23,435,677
Ensembl chr14:23,412,740...23,435,660
JBrowse link
G NFIX nuclear factor I X decreases expression EXP Bosentan results in decreased expression of NFIX mRNA CTD PMID:29761207 NCBI chr19:12,995,475...13,098,796
Ensembl chr19:12,995,475...13,098,796
JBrowse link
G NOX4 NADPH oxidase 4 decreases expression EXP Bosentan results in decreased expression of NOX4 mRNA CTD PMID:29761207 NCBI chr11:89,324,353...89,589,557
Ensembl chr11:89,324,353...89,498,187
JBrowse link
G NPPB natriuretic peptide B multiple interactions EXP Bosentan inhibits the reaction [MYH7 gene mutant form results in increased expression of NPPB protein] CTD PMID:29741611 NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression EXP Bosentan results in increased expression of NQO1 mRNA CTD PMID:29761207 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G NR1H2 nuclear receptor subfamily 1 group H member 2 decreases expression EXP Bosentan results in decreased expression of NR1H2 mRNA CTD PMID:29761207 NCBI chr19:50,376,457...50,383,388
Ensembl chr19:50,329,653...50,383,388
JBrowse link
G NR1H3 nuclear receptor subfamily 1 group H member 3 decreases expression EXP Bosentan results in decreased expression of NR1H3 mRNA CTD PMID:29761207 NCBI chr11:47,248,300...47,269,033
Ensembl chr11:47,248,300...47,269,033
JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 decreases expression EXP Bosentan results in decreased expression of NR1H4 mRNA CTD PMID:29761207 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414
JBrowse link
G PCK2 phosphoenolpyruvate carboxykinase 2, mitochondrial decreases expression EXP Bosentan results in decreased expression of PCK2 mRNA CTD PMID:29761207 NCBI chr14:24,094,311...24,104,125
Ensembl chr14:24,094,053...24,110,598
JBrowse link
G PGLYRP2 peptidoglycan recognition protein 2 affects expression EXP Bosentan affects the expression of PGLYRP2 mRNA CTD PMID:29761207 NCBI chr19:15,468,645...15,479,501
Ensembl chr19:15,468,645...15,498,956
JBrowse link
G PKLR pyruvate kinase L/R affects expression EXP Bosentan affects the expression of PKLR mRNA CTD PMID:29761207 NCBI chr 1:155,289,293...155,301,438
Ensembl chr 1:155,289,293...155,301,438
JBrowse link
G PON1 paraoxonase 1 decreases expression EXP Bosentan results in decreased expression of PON1 mRNA CTD PMID:29761207 NCBI chr 7:95,297,676...95,324,532
Ensembl chr 7:95,297,676...95,324,532
JBrowse link
G POR cytochrome p450 oxidoreductase affects expression EXP Bosentan affects the expression of POR mRNA CTD PMID:29761207 NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma decreases expression EXP Bosentan results in decreased expression of PPARG mRNA CTD PMID:29761207 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha decreases expression EXP Bosentan results in decreased expression of PPARGC1A mRNA CTD PMID:29761207 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP bosentan inhibits the reaction [Glucose results in increased activity of RELA protein] CTD PMID:12388107 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G SFTPA1 surfactant protein A1 multiple interactions ISO bosentan inhibits the reaction [Nitric Oxide Donors results in decreased expression of SFTPA1 mRNA]; bosentan inhibits the reaction [Nitric Oxide results in decreased expression of SFTPA1 mRNA]; bosentan inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPA1 mRNA] CTD PMID:15640287 NCBI chr10:79,610,939...79,615,455
Ensembl chr10:79,610,939...79,615,455
JBrowse link
G SFTPB surfactant protein B multiple interactions ISO bosentan inhibits the reaction [Nitric Oxide Donors results in decreased expression of SFTPB mRNA]; bosentan inhibits the reaction [Nitric Oxide results in decreased expression of SFTPB mRNA]; bosentan inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPB mRNA] CTD PMID:15640287 NCBI chr 2:85,657,307...85,668,741
Ensembl chr 2:85,657,314...85,668,741
JBrowse link
G SFTPC surfactant protein C multiple interactions ISO bosentan inhibits the reaction [Nitric Oxide Donors results in decreased expression of SFTPC mRNA]; bosentan inhibits the reaction [Nitric Oxide results in decreased expression of SFTPC mRNA]; bosentan inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPC mRNA] CTD PMID:15640287 NCBI chr 8:22,157,383...22,164,479
Ensembl chr 8:22,156,913...22,164,479
JBrowse link
G SLC10A1 solute carrier family 10 member 1 decreases expression ISO
EXP
bosentan results in decreased expression of SLC10A1 mRNA
Bosentan results in decreased expression of SLC10A1 mRNA
CTD PMID:27765674 PMID:28369585 PMID:29761207 NCBI chr14:69,775,416...69,797,241
Ensembl chr14:69,775,416...69,797,241
JBrowse link
G SLC22A7 solute carrier family 22 member 7 affects expression EXP Bosentan affects the expression of SLC22A7 mRNA CTD PMID:29761207 NCBI chr 6:43,295,710...43,305,538
Ensembl chr 6:43,295,694...43,305,538
JBrowse link
G SLC3A2 solute carrier family 3 member 2 increases expression EXP Bosentan results in increased expression of SLC3A2 mRNA; Bosentan results in increased expression of SLC3A2 protein CTD PMID:29761207 NCBI chr11:62,856,109...62,888,860
Ensembl chr11:62,856,004...62,888,880
JBrowse link
G SLC51A solute carrier family 51 subunit alpha increases expression EXP Bosentan results in increased expression of SLC51A mRNA CTD PMID:29761207 NCBI chr 3:196,216,534...196,233,427
Ensembl chr 3:196,211,487...196,243,178
JBrowse link
G SLC51B solute carrier family 51 subunit beta increases expression EXP Bosentan results in increased expression of SLC51B mRNA CTD PMID:29761207 NCBI chr15:65,045,387...65,053,397
Ensembl chr15:65,045,387...65,053,397
JBrowse link
G SLC6A1 solute carrier family 6 member 1 affects expression EXP Bosentan affects the expression of SLC6A1 mRNA CTD PMID:29761207 NCBI chr 3:10,992,748...11,039,247
Ensembl chr 3:10,992,186...11,039,247
JBrowse link
G SLCO1B1 solute carrier organic anion transporter family member 1B1 decreases expression EXP Bosentan results in decreased expression of SLCO1B1 mRNA CTD PMID:29761207 NCBI chr12:21,131,194...21,239,796
Ensembl chr12:21,131,194...21,239,796
JBrowse link
G SOD1 superoxide dismutase 1 decreases expression EXP Bosentan results in decreased expression of SOD1 mRNA CTD PMID:29761207 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 increases expression EXP Bosentan results in increased expression of SOD2 mRNA CTD PMID:29761207 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SULT1E1 sulfotransferase family 1E member 1 affects expression EXP Bosentan affects the expression of SULT1E1 mRNA CTD PMID:29761207 NCBI chr 4:69,841,212...69,860,151
Ensembl chr 4:69,841,212...69,860,145
JBrowse link
G TAT tyrosine aminotransferase affects expression EXP Bosentan affects the expression of TAT mRNA CTD PMID:29761207 NCBI chr16:71,565,660...71,577,092
Ensembl chr16:71,565,660...71,577,092
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions EXP bosentan inhibits the reaction [TGFB1 protein results in increased activity of EDN1 protein] CTD PMID:22796455 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO bosentan inhibits the reaction [Doxorubicin results in increased expression of TNF protein] CTD PMID:17974986 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TXN2 thioredoxin 2 decreases expression EXP Bosentan results in decreased expression of TXN2 mRNA CTD PMID:29761207 NCBI chr22:36,467,036...36,481,672
Ensembl chr22:36,467,046...36,481,640
JBrowse link
G TXNRD1 thioredoxin reductase 1 increases expression EXP Bosentan results in increased expression of TXNRD1 mRNA CTD PMID:29761207 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
JBrowse link
G UGT1A6 UDP glucuronosyltransferase family 1 member A6 decreases expression EXP Bosentan results in decreased expression of UGT1A6 mRNA CTD PMID:29761207 NCBI chr 2:233,691,702...233,773,300
Ensembl chr 2:233,691,607...233,773,300
JBrowse link
G UGT2B4 UDP glucuronosyltransferase family 2 member B4 decreases expression EXP Bosentan results in decreased expression of UGT2B4 mRNA CTD PMID:29761207 NCBI chr 4:69,480,165...69,526,014
Ensembl chr 4:69,480,165...69,526,014
JBrowse link
G VNN1 vanin 1 affects expression EXP Bosentan affects the expression of VNN1 mRNA CTD PMID:29761207 NCBI chr 6:132,680,849...132,714,055
Ensembl chr 6:132,680,849...132,714,055
JBrowse link
G XDH xanthine dehydrogenase decreases expression EXP Bosentan results in decreased expression of XDH mRNA CTD PMID:29761207 NCBI chr 2:31,334,320...31,414,777
Ensembl chr 2:31,334,321...31,414,742
JBrowse link
enrasentan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDNRA endothelin receptor type A multiple interactions EXP enrasentan binds to and results in decreased activity of EDNRA protein CTD PMID:16219361 NCBI chr 4:147,481,097...147,544,954
Ensembl chr 4:147,480,917...147,544,954
JBrowse link
G EDNRB endothelin receptor type B multiple interactions EXP enrasentan binds to and results in decreased activity of EDNRB protein CTD PMID:16219361 NCBI chr13:77,895,481...77,975,527
Ensembl chr13:77,895,481...77,975,529
JBrowse link
losartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions
EXP Losartan results in decreased activity of ABCB11 protein
Losartan inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:23956101 PMID:24014644 NCBI chr 2:168,915,468...169,031,396
Ensembl chr 2:168,915,498...169,031,324
JBrowse link
G ACE angiotensin I converting enzyme multiple interactions
decreases expression
ISO
EXP
Losartan inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of ACE protein]; Losartan inhibits the reaction [Oxygen deficiency results in increased expression of ACE protein]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of ACE mRNA]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of ACE protein]
Losartan results in decreased expression of ACE protein
CTD PMID:25511041 PMID:25655897 PMID:28091615 PMID:28578904 PMID:33007385 NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380
JBrowse link
G ACE2 angiotensin converting enzyme 2 multiple interactions
increases expression
increases activity
ISO Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of ACE2 protein]
Losartan results in increased expression of ACE2 protein
Losartan results in increased expression of ACE2 mRNA; Losartan results in increased expression of ACE2 protein
Losartan results in increased activity of ACE2 protein
Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [Oxygen deficiency results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 protein]
CTD PMID:15897343 PMID:16176966 PMID:16221218 PMID:20178811 PMID:22009550 PMID:25511041 PMID:25655897 PMID:28091615 PMID:33007385 NCBI chr  X:15,518,197...15,607,211
Ensembl chr  X:15,494,566...15,607,236
JBrowse link
G ACTA2 actin alpha 2, smooth muscle decreases expression
multiple interactions
ISO
EXP
Losartan results in decreased expression of ACTA2 mRNA; Losartan results in decreased expression of ACTA2 protein
Losartan inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]
CTD PMID:15100363 PMID:28091615 PMID:28578904 PMID:33007385 NCBI chr10:88,935,074...88,991,397
Ensembl chr10:88,935,074...88,991,339
JBrowse link
G ACTG2 actin gamma 2, smooth muscle decreases expression ISO Losartan results in decreased expression of ACTG2 mRNA CTD PMID:15100363 NCBI chr 2:73,893,008...73,919,865
Ensembl chr 2:73,892,314...73,919,865
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing increases expression ISO Losartan results in increased expression of ADIPOQ mRNA CTD PMID:19730415 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
JBrowse link
G ADRB2 adrenoceptor beta 2 affects expression ISO Losartan affects the expression of ADRB2 protein CTD PMID:9260993 NCBI chr 5:148,826,611...148,828,623
Ensembl chr 5:148,826,611...148,828,623
JBrowse link
G AFP alpha fetoprotein multiple interactions ISO Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein] CTD PMID:29859236 NCBI chr 4:73,436,221...73,456,174
Ensembl chr 4:73,431,138...73,456,174
JBrowse link
G AGER advanced glycosylation end-product specific receptor multiple interactions ISO Losartan inhibits the reaction [Glucose promotes the reaction [Linoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]; Losartan inhibits the reaction [Linoleic Acid promotes the reaction [Glucose promotes the reaction [Azoxymethane results in increased expression of AGER protein]]] CTD PMID:22467055 NCBI chr 6:32,180,969...32,184,380
Ensembl chr 6:32,180,968...32,184,322
JBrowse link
G AGT angiotensinogen multiple interactions
increases secretion
decreases activity
decreases response to substance
increases expression
decreases expression
EXP
ISO
[Losartan co-treated with ICG 001] inhibits the reaction [AGT protein results in decreased expression of NPHS2 protein]; [Losartan co-treated with ICG 001] inhibits the reaction [AGT protein results in increased expression of S100A4 protein]; [Losartan results in decreased activity of AGTR1 protein] which results in increased expression of AGT protein alternative form; ICG 001 promotes the reaction [Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]]; ICG 001 promotes the reaction [Losartan inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]]; Losartan inhibits the reaction [[AGT protein modified form co-treated with Ascorbic Acid co-treated with Copper Sulfate] results in increased chemical synthesis of [4-hydroxy-2-nonenal binds to AGT protein modified form]]; Losartan inhibits the reaction [[AGT protein modified form co-treated with Ascorbic Acid co-treated with Copper Sulfate] results in increased chemical synthesis of [pyruvamide binds to AGT protein modified form]]; Losartan inhibits the reaction [AGT protein affects the localization of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein modified form promotes the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]]; Losartan inhibits the reaction [AGT protein modified form results in decreased secretion of Nitric Oxide]; Losartan inhibits the reaction [AGT protein modified form results in increased expression of EDN1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of HMOX1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of NFE2L2 protein]; Losartan inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; Losartan inhibits the reaction [AGT protein results in increased expression of ACE protein]; Losartan inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGT protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; Losartan inhibits the reaction [AGT protein results in increased expression of and results in increased activity of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CCL2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of REN protein]; Losartan inhibits the reaction [AGT protein results in increased expression of S100A4 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of TWIST1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of VIM protein]; Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 protein]; Losartan inhibits the reaction [AGT protein results in increased secretion of ICAM1 protein]; Losartan promotes the reaction [AGT protein results in increased expression of VEGFA mRNA]; Losartan promotes the reaction [AGT protein results in increased secretion of VEGFA protein]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of MMP7 protein]]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]]
Losartan results in increased secretion of AGT protein; Losartan results in increased secretion of AGT protein alternative form
[Losartan results in decreased activity of AGT protein] which results in decreased activity of TGFB1 protein; Losartan results in decreased activity of AGT protein
Losartan results in decreased susceptibility to AGT protein modified form
Losartan results in increased expression of AGT protein
Losartan results in decreased activity of AGT protein; Losartan results in decreased activity of AGT protein modified form
Losartan results in decreased expression of AGT protein; Losartan results in decreased expression of AGT protein alternative form; Losartan results in decreased expression of AGT protein modified form
[Lisinopril co-treated with Losartan] results in increased expression of AGT mRNA; [Losartan co-treated with Carvedilol] results in decreased susceptibility to AGT protein modified form; Carvedilol inhibits the reaction [Losartan results in decreased susceptibility to AGT protein modified form]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Losartan inhibits the reaction [[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein]; Losartan inhibits the reaction [AGT protein affects the abundance of Cholesterol]; Losartan inhibits the reaction [AGT protein affects the localization of Calcium]; Losartan inhibits the reaction [AGT protein affects the localization of Lipids]; Losartan inhibits the reaction [AGT protein alternative form results in increased expression of PDGFA mRNA alternative form]; Losartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; Losartan inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]; Losartan inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 mRNA]; Losartan inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 protein]; Losartan inhibits the reaction [AGT protein modified form results in increased phosphorylation of GSK3B protein]; Losartan inhibits the reaction [AGT protein modified form results in increased phosphorylation of MAPT protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of CPT1A mRNA]; Losartan inhibits the reaction [AGT protein results in increased abundance of Fatty Acids, Nonesterified]; Losartan inhibits the reaction [AGT protein results in increased abundance of Glycerol]; Losartan inhibits the reaction [AGT protein results in increased abundance of Norepinephrine]; Losartan inhibits the reaction [AGT protein results in increased abundance of Triglycerides]; Losartan inhibits the reaction [AGT protein results in increased activity of CREB1 protein]; Losartan inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of ATP1A1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of ENG protein]; Losartan inhibits the reaction [AGT protein results in increased expression of FASN mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of FOS protein]; Losartan inhibits the reaction [AGT protein results in increased expression of HMGCR mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of HSPA5 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of MYLK protein]; Losartan inhibits the reaction [AGT protein results in increased expression of PARP1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of PDGFB mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PDGFD mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PDGFRB mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of POSTN mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PPARA mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PPARG mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PPARGC1A mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PTHLH mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PTHLH protein]; Losartan inhibits the reaction [AGT protein results in increased expression of REG3G mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of SREBF1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of TSC22D1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of UCP2 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of UCP3 mRNA]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of EIF2S1 protein]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of SREBF1 protein]; Losartan inhibits the reaction [AGT protein results in increased secretion of COL3A1 protein]; Losartan inhibits the reaction [AGT protein results in increased secretion of PRL protein]; Losartan inhibits the reaction [Carvedilol results in decreased susceptibility to AGT protein modified form]; Losartan inhibits the reaction [Ethanol results in increased secretion of AGT protein alternative form]; Losartan inhibits the reaction [Folic Acid results in increased localization of [AGT protein binds to AGTR1A protein]]; Losartan inhibits the reaction [Folic Acid results in increased localization of AGT protein]; Losartan inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; Losartan inhibits the reaction [Sodium Chloride results in increased expression of AGT protein]; Losartan inhibits the reaction [Tobacco Smoke Pollution results in increased expression of AGT protein]; Losartan promotes the reaction [AGTR2 protein binds to AGT protein]; Losartan promotes the reaction [Isoproterenol results in increased expression of AGT protein]
Losartan inhibits the reaction [AGT protein affects the localization of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in decreased abundance of angiotensin I (1-7)]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of NFE2L2 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of NPHS1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of PODXL protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of WT1 protein]; Losartan inhibits the reaction [AGT protein results in increased activity of PARP1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of ACE protein]; Losartan inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGT protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AKT2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CCL2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of DES protein]; Losartan inhibits the reaction [AGT protein results in increased expression of FOS protein]; Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of RELA protein]; Losartan inhibits the reaction [AGT protein results in increased expression of REN1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of SOD3 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of TWIST1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of VIM protein]; Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 protein]; Losartan inhibits the reaction [Silicon Dioxide results in decreased expression of AGT protein alternative form]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of AGT protein]
CTD PMID:1387008 PMID:7965263 PMID:8403307 PMID:8952583 PMID:9124547 PMID:9176287 PMID:9519251 PMID:9533614 PMID:10082498 PMID:10400907 PMID:10517737 PMID:11463773 PMID:11709406 PMID:11967826 PMID:12084390 PMID:12411096 PMID:12431451 PMID:12692751 PMID:14630723 PMID:14722030 PMID:15121739 PMID:15213268 PMID:15361886 PMID:15502880 PMID:15528393 PMID:15539634 PMID:15728788 PMID:15741261 PMID:15897343 PMID:16176966 PMID:16221218 PMID:16251426 PMID:16539842 PMID:17043664 PMID:17224469 PMID:17481528 PMID:17666345 PMID:18060435 PMID:18267125 PMID:18511912 PMID:19109942 PMID:19183357 PMID:19298698 PMID:20178811 PMID:20232302 PMID:21047287 PMID:21152098 PMID:21166975 PMID:21613610 PMID:21613793 PMID:22982071 PMID:22982863 PMID:23300732 PMID:23875703 PMID:25398788 PMID:26464165 PMID:27798352 PMID:28578904 PMID:29609002 PMID:31144504 PMID:33007385 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576
JBrowse link
G AGTR1 angiotensin II receptor type 1 multiple interactions
decreases expression
increases expression
decreases activity
EXP
ISO
[Losartan results in decreased activity of AGTR1 protein] which results in decreased abundance of Aldosterone; [Losartan results in decreased activity of AGTR1 protein] which results in increased expression of AGT protein alternative form; [Losartan results in decreased activity of AGTR1 protein] which results in increased expression of REN protein; Losartan binds to and results in decreased activity of AGTR1 protein; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]
Losartan results in decreased expression of AGTR1 protein; Losartan results in decreased expression of AGTR1A mRNA; Losartan results in decreased expression of AGTR1A protein
Losartan binds to and results in decreased activity of AGTR1A protein; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; Losartan inhibits the reaction [Hydrogen Peroxide results in increased expression of AGTR1A mRNA]; Losartan inhibits the reaction [Oxygen deficiency results in increased expression of AGTR1 protein]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of AGTR1 protein]
Losartan results in increased expression of AGTR1 mRNA; Losartan results in increased expression of AGTR1A mRNA
[Cilazapril co-treated with Losartan] promotes the reaction [Doxorubicin results in increased expression of AGTR1 mRNA]; Losartan binds to and results in decreased activity of AGTR1 protein; Losartan binds to and results in decreased activity of AGTR1A protein; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased expression of AGTR1A mRNA]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased expression of AGTR1A protein]; Losartan inhibits the reaction [Doxorubicin results in increased expression of AGTR1 mRNA]; Losartan inhibits the reaction [Doxorubicin results in increased expression of AGTR1 protein]; Losartan inhibits the reaction [Folic Acid results in increased localization of [AGT protein binds to AGTR1A protein]]
CTD PMID:9124547 PMID:9533614 PMID:10821809 PMID:11893553 PMID:12930639 PMID:15157388 PMID:15331931 PMID:15528393 PMID:15728788 PMID:15807884 PMID:15809360 PMID:18267125 PMID:18300857 PMID:18765277 PMID:22306536 PMID:25511041 PMID:28091615 PMID:28578904 PMID:33007385 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008
JBrowse link
G AGTR2 angiotensin II receptor type 2 multiple interactions
increases expression
decreases expression
ISO [Losartan co-treated with Cilazapril] inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA]; Losartan inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA]; Losartan promotes the reaction [AGTR2 protein binds to AGT protein]
Losartan inhibits the reaction [Oxygen deficiency results in decreased expression of AGTR2 protein]
Losartan results in increased expression of AGTR2 protein
Losartan results in decreased expression of AGTR2 mRNA
CTD PMID:9336375 PMID:11967826 PMID:15331931 PMID:18300857 PMID:25511041 NCBI chr  X:116,170,744...116,174,974
Ensembl chr  X:116,170,744...116,174,974
JBrowse link
G AKT2 AKT serine/threonine kinase 2 multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of AKT2 protein] CTD PMID:28578904 NCBI chr19:40,230,317...40,285,531
Ensembl chr19:40,230,317...40,285,536
JBrowse link
G ALB albumin affects binding EXP Losartan binds to ALB protein; Losartan binds to ALB protein modified form CTD PMID:27470663 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G ALOX15 arachidonate 15-lipoxygenase decreases expression ISO Losartan results in decreased expression of ALOX15 mRNA; Losartan results in decreased expression of ALOX15 protein CTD PMID:15100363 NCBI chr17:4,630,919...4,641,678
Ensembl chr17:4,630,919...4,642,294
JBrowse link
G ALOX5 arachidonate 5-lipoxygenase decreases expression ISO Losartan results in decreased expression of ALOX5 protein CTD PMID:21377515 NCBI chr10:45,374,209...45,446,121
Ensembl chr10:45,374,176...45,446,119
JBrowse link
G AMBP alpha-1-microglobulin/bikunin precursor decreases expression
multiple interactions
EXP Losartan results in decreased expression of AMBP protein
benazepril promotes the reaction [Losartan results in decreased expression of AMBP protein]; Losartan promotes the reaction [benazepril results in decreased expression of AMBP protein]
CTD PMID:16303729 NCBI chr 9:114,060,127...114,078,300
Ensembl chr 9:114,060,127...114,078,328
JBrowse link
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of ATP1A1 mRNA] CTD PMID:14630723 NCBI chr 1:116,372,986...116,410,259
Ensembl chr 1:116,372,668...116,410,261
JBrowse link
G ATP1A2 ATPase Na+/K+ transporting subunit alpha 2 increases expression ISO Losartan results in increased expression of ATP1A2 mRNA; Losartan results in increased expression of ATP1A2 protein CTD PMID:18418421 NCBI chr 1:160,115,759...160,143,591
Ensembl chr 1:160,115,759...160,143,591
JBrowse link
G ATP1A3 ATPase Na+/K+ transporting subunit alpha 3 decreases expression ISO Losartan results in decreased expression of ATP1A3 mRNA; Losartan results in decreased expression of ATP1A3 protein CTD PMID:18418421 NCBI chr19:41,966,582...41,994,230
Ensembl chr19:41,966,582...41,997,497
JBrowse link
G BAK1 BCL2 antagonist/killer 1 multiple interactions ISO Losartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAK1 mRNA] CTD PMID:15502641 NCBI chr 6:33,572,552...33,580,296
Ensembl chr 6:33,572,547...33,580,293
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
increases expression
decreases expression
ISO Losartan inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]; Losartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAX mRNA]
Losartan results in increased expression of BAX protein
Losartan results in decreased expression of BAX mRNA
CTD PMID:12623880 PMID:12845756 PMID:15502641 PMID:17784886 PMID:19298698 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
affects expression
increases expression
decreases expression
ISO Losartan promotes the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of BCL2 mRNA]
Losartan affects the expression of BCL2 protein
Losartan results in increased expression of BCL2 protein
Losartan results in decreased expression of BCL2 protein
CTD PMID:12623880 PMID:15502641 PMID:19298698 PMID:21153712 PMID:22000973 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BMP2 bone morphogenetic protein 2 multiple interactions ISO Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 mRNA]; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 protein] CTD PMID:27412937 NCBI chr20:6,767,686...6,780,246
Ensembl chr20:6,767,686...6,780,246
JBrowse link
G CAMK2A calcium/calmodulin dependent protein kinase II alpha multiple interactions ISO [KN 93 co-treated with Losartan] inhibits the reaction [bisphenol A results in increased phosphorylation of CAMK2A protein]; Losartan inhibits the reaction [bisphenol A results in increased phosphorylation of CAMK2A protein] CTD PMID:25103225 NCBI chr 5:150,219,491...150,290,130
Ensembl chr 5:150,219,491...150,290,093
JBrowse link
G CASP3 caspase 3 increases cleavage
decreases activity
multiple interactions
ISO Losartan results in increased cleavage of CASP3 protein
Losartan results in decreased activity of CASP3 protein
Losartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]
CTD PMID:12623880 PMID:23300732 PMID:23875703 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP8 caspase 8 decreases activity ISO Losartan results in decreased activity of CASP8 protein CTD PMID:23875703 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CASP9 caspase 9 increases cleavage ISO Losartan results in increased cleavage of CASP9 protein CTD PMID:12623880 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase decreases expression
multiple interactions
ISO Losartan results in decreased expression of CAT protein
Losartan inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
CTD PMID:23875703 PMID:30958922 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
ISO
EXP
Losartan inhibits the reaction [Estrogens deficiency results in increased expression of CCL2 protein]; Losartan inhibits the reaction [Ethylene Glycol results in increased expression of CCL2 protein]
Losartan inhibits the reaction [AGT protein results in increased expression of CCL2 protein]
Losartan results in decreased expression of CCL2 mRNA; Losartan results in decreased expression of CCL2 protein
CTD PMID:10925121 PMID:16284884 PMID:17922026 PMID:19553526 PMID:28578904 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CCL3 C-C motif chemokine ligand 3 multiple interactions ISO Losartan inhibits the reaction [Estrogens deficiency results in increased expression of CCL3 protein] CTD PMID:19553526 NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169
JBrowse link
G CCL5 C-C motif chemokine ligand 5 multiple interactions ISO Losartan inhibits the reaction [Ethylene Glycol results in increased expression of CCL5 protein] CTD PMID:16284884 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793
JBrowse link
G CCND1 cyclin D1 multiple interactions ISO Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA] CTD PMID:29859236 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCR2 C-C motif chemokine receptor 2 decreases expression ISO Losartan results in decreased expression of CCR2 mRNA CTD PMID:17922026 NCBI chr 3:46,354,111...46,360,940
Ensembl chr 3:46,353,864...46,360,940
JBrowse link
G CD36 CD36 molecule increases expression
decreases expression
multiple interactions
EXP
ISO
Losartan results in increased expression of CD36 mRNA
Losartan results in decreased expression of CD36 mRNA
Losartan promotes the reaction [[Dietary Fats co-treated with Cholesterol] results in increased expression of CD36 mRNA]
T 0070907 inhibits the reaction [Losartan results in increased expression of CD36 mRNA]
CTD PMID:18302760 PMID:22124178 NCBI chr 7:80,602,207...80,679,277
Ensembl chr 7:80,369,575...80,679,277
JBrowse link
G CD74 CD74 molecule decreases expression ISO Losartan results in decreased expression of CD74 mRNA CTD PMID:15100363 NCBI chr 5:150,401,637...150,412,910
Ensembl chr 5:150,400,041...150,412,969
JBrowse link
G CDH1 cadherin 1 multiple interactions EXP
ISO
Losartan inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]
Losartan inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; Losartan inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]
CTD PMID:28578904 PMID:33007385 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions EXP Losartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN1A protein] CTD PMID:33380422 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337
JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A multiple interactions EXP Losartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN2A protein] CTD PMID:33380422 NCBI chr 9:21,967,752...21,995,324
Ensembl chr 9:21,967,752...21,995,301
JBrowse link
G COL1A1 collagen type I alpha 1 chain decreases expression
multiple interactions
ISO Losartan results in decreased expression of COL1A1 mRNA
Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of COL1A1 mRNA]
CTD PMID:15100363 PMID:18300870 PMID:23585870 NCBI chr17:50,184,096...50,201,649
Ensembl chr17:50,184,101...50,201,632
JBrowse link
G COL3A1 collagen type III alpha 1 chain decreases expression
multiple interactions
ISO
EXP
Losartan results in decreased expression of COL3A1 mRNA
Losartan inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]
Losartan inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of COL3A1 mRNA]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of COL3A1 protein]
Losartan inhibits the reaction [AGT protein results in increased secretion of COL3A1 protein]; Losartan inhibits the reaction [Paraquat results in increased expression of COL3A1 protein]
CTD PMID:15100363 PMID:16539842 PMID:23585870 PMID:25233898 PMID:28578904 PMID:33007385 NCBI chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746
JBrowse link
G COL4A1 collagen type IV alpha 1 chain decreases expression ISO Losartan results in decreased expression of COL4A1 mRNA CTD PMID:16191423 NCBI chr13:110,148,963...110,307,157
Ensembl chr13:110,148,963...110,307,157
JBrowse link
G CPT1A carnitine palmitoyltransferase 1A multiple interactions ISO Losartan inhibits the reaction [AGT protein results in decreased expression of CPT1A mRNA] CTD PMID:19109942 NCBI chr11:68,754,620...68,844,410
Ensembl chr11:68,754,620...68,844,410
JBrowse link
G CREB1 cAMP responsive element binding protein 1 multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased activity of CREB1 protein]; Losartan inhibits the reaction [Folic Acid results in increased activity of CREB1 protein] CTD PMID:15728788 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G CTNNB1 catenin beta 1 multiple interactions ISO
EXP
Losartan inhibits the reaction [AGT protein affects the localization of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 protein]
Losartan inhibits the reaction [AGT protein affects the localization of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of and results in increased activity of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 mRNA]
CTD PMID:28578904 NCBI chr 3:41,199,422...41,240,445
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CUBN cubilin multiple interactions ISO Losartan inhibits the reaction [Cadmium results in decreased expression of CUBN protein] CTD PMID:24093454 NCBI chr10:16,823,966...17,130,492
Ensembl chr10:16,823,966...17,129,811
JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 multiple interactions ISO Losartan inhibits the reaction [Estrogens deficiency results in increased expression of CXCL1 protein] CTD PMID:19553526 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308
JBrowse link
G CYCS cytochrome c, somatic increases expression ISO Losartan results in increased expression of CYCS protein CTD PMID:18971572 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression EXP Losartan results in increased expression of CYP1A1 mRNA CTD PMID:9860486 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 affects metabolic processing
increases hydroxylation
multiple interactions
increases metabolic processing
EXP CYP2C9 protein affects the metabolism of Losartan
CYP2C9 protein results in increased hydroxylation of Losartan
CYP2C9 gene mutant form inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Losartan]; resveratrol inhibits the reaction [CYP2C9 protein results in increased metabolism of Losartan]
CTD PMID:19082874 PMID:19715737 PMID:20405111 PMID:20716633 PMID:21321060 PMID:25994031 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G DCN decorin decreases expression ISO Losartan results in decreased expression of DCN mRNA CTD PMID:15100363 NCBI chr12:91,140,484...91,182,817
Ensembl chr12:91,140,484...91,183,217
JBrowse link
G DES desmin multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of DES protein] CTD PMID:28578904 NCBI chr 2:219,418,377...219,426,734
Ensembl chr 2:219,418,377...219,426,735
JBrowse link
G EDN1 endothelin 1 decreases expression
multiple interactions
EXP
ISO
Losartan results in decreased expression of EDN1 protein
Losartan results in decreased expression of EDN1 mRNA; Losartan results in decreased expression of EDN1 protein
Losartan inhibits the reaction [Nitroglycerin results in increased expression of EDN1 protein]
Losartan inhibits the reaction [AGT protein modified form results in increased expression of EDN1 protein]
CTD PMID:11369837 PMID:12901495 PMID:16191423 PMID:17666345 PMID:18971572 NCBI chr 6:12,256,463...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G EDNRA endothelin receptor type A multiple interactions
decreases expression
ISO Atorvastatin promotes the reaction [Losartan results in decreased expression of EDNRA mRNA]; Losartan promotes the reaction [Atorvastatin results in decreased expression of EDNRA mRNA] CTD PMID:23091284 NCBI chr 4:147,481,097...147,544,954
Ensembl chr 4:147,480,917...147,544,954
JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased phosphorylation of EIF2S1 protein] CTD PMID:25398788 NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,328...67,386,516
JBrowse link
G ELN elastin decreases expression ISO Losartan results in decreased expression of ELN mRNA CTD PMID:15100363 NCBI chr 7:74,027,772...74,069,907
Ensembl chr 7:74,027,789...74,069,907
JBrowse link
G ENG endoglin multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of ENG protein] CTD PMID:15539634 NCBI chr 9:127,815,012...127,854,773
Ensembl chr 9:127,815,013...127,854,658
JBrowse link
G F3 coagulation factor III, tissue factor decreases expression
multiple interactions
EXP Losartan results in decreased expression of F3 mRNA; Losartan results in decreased expression of F3 protein
Losartan inhibits the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]; Losartan inhibits the reaction [AGT protein modified form promotes the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]]
CTD PMID:18060435 PMID:22188725 NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759
JBrowse link
G FASLG Fas ligand decreases expression ISO Losartan results in decreased expression of FASLG mRNA CTD PMID:10925121 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
JBrowse link
G FASN fatty acid synthase multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of FASN mRNA] CTD PMID:19109942 NCBI chr17:82,078,338...82,098,303
Ensembl chr17:82,078,338...82,098,294
JBrowse link
G FLT1 fms related receptor tyrosine kinase 1 decreases expression ISO Losartan results in decreased expression of FLT1 mRNA; Losartan results in decreased expression of FLT1 protein CTD PMID:19771429 NCBI chr13:28,300,346...28,495,128
Ensembl chr13:28,300,346...28,495,145
JBrowse link
G FLT4 fms related receptor tyrosine kinase 4 decreases expression ISO Losartan results in decreased expression of FLT4 mRNA CTD PMID:19771429 NCBI chr 5:180,601,506...180,650,298
Ensembl chr 5:180,601,506...180,649,624
JBrowse link
G FN1 fibronectin 1 decreases expression ISO Losartan results in decreased expression of FN1 mRNA; Losartan results in decreased expression of FN1 protein CTD PMID:16191423 NCBI chr 2:215,360,862...215,436,167
Ensembl chr 2:215,360,440...215,436,073
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of FOS protein]; Losartan inhibits the reaction [Furosemide results in increased expression of FOS protein]; Losartan inhibits the reaction [Polyethylene Glycols results in increased expression of FOS protein] CTD PMID:11463773 PMID:15528393 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G GJA1 gap junction protein alpha 1 increases expression ISO Losartan results in increased expression of GJA1 protein CTD PMID:18971572 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727
JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO Losartan inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]
Losartan inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]
CTD PMID:15573910 PMID:29859236 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
JBrowse link
G GSK3B glycogen synthase kinase 3 beta multiple interactions ISO Losartan inhibits the reaction [AGT protein modified form results in increased phosphorylation of GSK3B protein] CTD PMID:22982863 NCBI chr 3:119,821,321...120,095,823
Ensembl chr 3:119,821,321...120,094,994
JBrowse link
G HAVCR1 hepatitis A virus cellular receptor 1 multiple interactions ISO Losartan inhibits the reaction [Cadmium results in increased expression of HAVCR1] CTD PMID:24093454 NCBI chr 5:157,028,383...157,069,633
Ensembl chr 5:157,029,413...157,059,119
JBrowse link
G HLA-DRA major histocompatibility complex, class II, DR alpha decreases expression ISO Losartan results in decreased expression of RT1-DA mRNA CTD PMID:15100363 NCBI chr 6:32,439,887...32,445,046
Ensembl chr 6:32,439,878...32,445,046
JBrowse link
G HLA-E major histocompatibility complex, class I, E decreases expression ISO Losartan results in decreased expression of RT1-S3 mRNA CTD PMID:15100363 NCBI chr 6:30,489,508...30,494,194
Ensembl chr 6:30,489,509...30,494,194
JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of HMGCR mRNA] CTD PMID:19109942 NCBI chr 5:75,336,334...75,362,116
Ensembl chr 5:75,336,329...75,364,001
JBrowse link
G HMOX1 heme oxygenase 1 increases activity
multiple interactions
increases expression
ISO
EXP
Losartan results in increased activity of HMOX1 protein
Losartan inhibits the reaction [AGT protein results in decreased expression of HMOX1 protein]
Losartan results in increased expression of HMOX1 mRNA
cobaltiprotoporphyrin promotes the reaction [Losartan results in increased activity of HMOX1 protein]; cobaltiprotoporphyrin promotes the reaction [Losartan results in increased expression of HMOX1 mRNA]
CTD PMID:19804535 PMID:28578904 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of HSPA5 protein] CTD PMID:25398788 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382
JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions
decreases secretion
EXP Losartan inhibits the reaction [AGT protein results in increased secretion of ICAM1 protein]
Losartan results in decreased secretion of ICAM1 protein
CTD PMID:10517737 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G IFNG interferon gamma increases expression ISO Losartan results in increased expression of IFNG protein CTD PMID:23875703 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL10 interleukin 10 increases expression ISO Losartan results in increased expression of IL10 mRNA CTD PMID:18971572 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL1A interleukin 1 alpha multiple interactions
decreases expression
EXP
ISO
Losartan inhibits the reaction [IL1A protein results in increased expression of VEGFA mRNA]; Losartan inhibits the reaction [IL1A protein results in increased expression of VEGFA protein]
Losartan results in decreased expression of IL1A protein
CTD PMID:17299153 PMID:23875703 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G IL6 interleukin 6 decreases expression
increases expression
multiple interactions
ISO Losartan results in decreased expression of IL6 mRNA
Losartan results in increased expression of IL6 protein
Losartan inhibits the reaction [bisphenol A results in increased expression of IL6 mRNA]; Losartan inhibits the reaction [Ethylene Glycol results in increased expression of IL6 protein]
CTD PMID:16284884 PMID:21479465 PMID:23875703 PMID:30677511 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G ITGA3 integrin subunit alpha 3 decreases expression ISO Losartan results in decreased expression of ITGA3 protein CTD PMID:15100363 NCBI chr17:50,056,065...50,090,481
Ensembl chr17:50,055,968...50,090,481
JBrowse link
G ITGA6 integrin subunit alpha 6 decreases expression ISO Losartan results in decreased expression of ITGA6 protein CTD PMID:15100363 NCBI chr 2:172,427,336...172,506,459
Ensembl chr 2:172,427,354...172,506,459
JBrowse link
G JAK2 Janus kinase 2 multiple interactions EXP losartan inhibits the reaction [Angiotensin II increases phosphorylation of JAK2 protein in liver] RGD PMID:22613986 RGD:127285667 NCBI chr 9:4,984,390...5,129,948
Ensembl chr 9:4,984,390...5,129,948
JBrowse link
G KDR kinase insert domain receptor multiple interactions ISO Losartan inhibits the reaction [Cyclosporine results in increased expression of KDR mRNA] CTD PMID:12110003 NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595
JBrowse link
G KRAS KRAS proto-oncogene, GTPase multiple interactions EXP Losartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN1A protein]; Losartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN2A protein] CTD PMID:33380422 NCBI chr12:25,205,246...25,250,929
Ensembl chr12:25,205,246...25,250,936
JBrowse link
G LOX lysyl oxidase decreases expression ISO Losartan results in decreased expression of LOX mRNA CTD PMID:15100363 NCBI chr 5:122,063,195...122,078,259
Ensembl chr 5:122,063,195...122,078,413
JBrowse link
G LUM lumican decreases expression ISO Losartan results in decreased expression of LUM mRNA CTD PMID:15100363 NCBI chr12:91,102,629...91,111,494
Ensembl chr12:91,102,629...91,111,494
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
increases activity
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Losartan results in increased phosphorylation of MAPK1 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]
Losartan results in increased activity of MAPK1 protein
Losartan inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein]
CTD PMID:11711055 PMID:16079071 PMID:18267125 PMID:18511912 PMID:20056918 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK14 mitogen-activated protein kinase 14 decreases expression ISO Losartan results in decreased expression of MAPK14 protein CTD PMID:28091615 NCBI chr 6:36,027,711...36,122,964
Ensembl chr 6:36,027,677...36,111,236
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
increases activity
EXP
ISO
Losartan inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK3 protein]
Losartan results in increased phosphorylation of MAPK3 protein
Losartan results in increased activity of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Losartan results in increased phosphorylation of MAPK3 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]
CTD PMID:11711055 PMID:16079071 PMID:18267125 PMID:18511912 PMID:20056918 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPT microtubule associated protein tau multiple interactions ISO Losartan inhibits the reaction [AGT protein modified form results in increased phosphorylation of MAPT protein] CTD PMID:22982863 NCBI chr17:45,894,538...46,028,334
Ensembl chr17:45,894,527...46,028,334
JBrowse link
G MAS1 MAS1 proto-oncogene, G protein-coupled receptor multiple interactions ISO Losartan inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; Losartan inhibits the reaction [Silicon Dioxide results in decreased expression of MAS1 protein] CTD PMID:33007385 NCBI chr 6:159,890,988...159,917,447
Ensembl chr 6:159,890,988...159,917,447
JBrowse link
G MGP matrix Gla protein decreases expression ISO Losartan results in decreased expression of MGP mRNA CTD PMID:15100363 NCBI chr12:14,880,864...14,885,854
Ensembl chr12:14,880,864...14,885,857
JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions ISO Losartan inhibits the reaction [[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased activity of MMP2 protein]
Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of MMP2 protein]; Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 mRNA]
CTD PMID:12930639 PMID:16251426 PMID:23585870 PMID:29859236 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MMP23B matrix metallopeptidase 23B decreases expression ISO Losartan results in decreased expression of MMP23 mRNA CTD PMID:15100363 NCBI chr 1:1,631,681...1,635,638
Ensembl chr 1:1,632,163...1,635,263
JBrowse link
G MMP7 matrix metallopeptidase 7 multiple interactions ISO
EXP
Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]
ICG 001 promotes the reaction [Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]]; Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of MMP7 protein]]
CTD PMID:28578904 NCBI chr11:102,520,508...102,530,747
Ensembl chr11:102,520,508...102,530,750
JBrowse link
G MMP9 matrix metallopeptidase 9 decreases expression
multiple interactions
ISO Losartan results in decreased expression of MMP9 mRNA
Losartan inhibits the reaction [Paraquat results in increased expression of MMP9 mRNA]
Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]
CTD PMID:18971572 PMID:23585870 PMID:25233898 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor affects expression ISO Losartan affects the expression of MYC protein CTD PMID:22000973 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G MYH11 myosin heavy chain 11 decreases expression ISO Losartan results in decreased expression of MYH11 mRNA CTD PMID:15100363 NCBI chr16:15,703,135...15,857,032
Ensembl chr16:15,703,135...15,857,028
JBrowse link
G MYH6 myosin heavy chain 6 multiple interactions ISO Losartan inhibits the reaction [Streptozocin results in decreased expression of MYH6 mRNA]; Losartan inhibits the reaction [Streptozocin results in decreased expression of MYH6 protein] CTD PMID:15362513 NCBI chr14:23,381,987...23,408,273
Ensembl chr14:23,381,982...23,408,273
JBrowse link
G MYH7 myosin heavy chain 7 multiple interactions ISO Losartan inhibits the reaction [Streptozocin results in increased expression of MYH7 mRNA]; Losartan inhibits the reaction [Streptozocin results in increased expression of MYH7 protein] CTD PMID:15362513 NCBI chr14:23,412,740...23,435,677
Ensembl chr14:23,412,740...23,435,660
JBrowse link
G MYLK myosin light chain kinase multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of MYLK protein] CTD PMID:18511912 NCBI chr 3:123,610,049...123,884,332
Ensembl chr 3:123,610,049...123,884,332
JBrowse link
G NCF1 neutrophil cytosolic factor 1 multiple interactions ISO Losartan inhibits the reaction [Hydrogen Peroxide results in increased expression of NCF1 mRNA]
Losartan inhibits the reaction [Ethanol affects the localization of NCF1 protein]
CTD PMID:22306536 PMID:22497828 PMID:22982071 NCBI chr 7:74,774,011...74,789,315
Ensembl chr 7:74,773,962...74,789,376
JBrowse link
G NDST1 N-deacetylase and N-sulfotransferase 1 multiple interactions ISO Losartan inhibits the reaction [Streptozocin results in decreased expression of NDST1 protein] CTD PMID:15793251 NCBI chr 5:150,497,779...150,558,211
Ensembl chr 5:150,485,818...150,558,211
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 decreases expression
multiple interactions
ISO
EXP
Losartan results in decreased expression of NFE2L2 mRNA
Losartan inhibits the reaction [AGT protein results in decreased expression of NFE2L2 protein]
CTD PMID:18765277 PMID:28578904 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions ISO Losartan inhibits the reaction [Ethylene Glycol results in increased expression of NFKB1 protein]
Losartan inhibits the reaction [Diethylnitrosamine results in decreased expression of NFKB1 protein]
CTD PMID:16284884 PMID:29859236 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302
JBrowse link
G NOS1 nitric oxide synthase 1 increases phosphorylation
multiple interactions
ISO Losartan results in increased phosphorylation of NOS1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Losartan results in increased phosphorylation of NOS1 protein]
CTD PMID:20056918 NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170
JBrowse link
G NOS2 nitric oxide synthase 2 affects expression
decreases expression
increases expression
ISO Losartan affects the expression of NOS2 mRNA
Losartan results in decreased expression of NOS2 mRNA; Losartan results in decreased expression of NOS2 protein
Losartan results in increased expression of NOS2 protein
CTD PMID:12198324 PMID:16191423 PMID:18390819 PMID:21377515 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NOS3 nitric oxide synthase 3 affects expression
increases expression
multiple interactions
increases phosphorylation
ISO Losartan affects the expression of NOS3 mRNA
Losartan results in increased expression of NOS3 mRNA
[Losartan co-treated with Atorvastatin] results in increased expression of NOS3 mRNA; Losartan inhibits the reaction [Sodium Chloride results in decreased expression of NOS3 protein]
Losartan results in increased phosphorylation of NOS3 protein
CTD PMID:12198324 PMID:18390819 PMID:18971572 PMID:20232302 PMID:23091284 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
JBrowse link
G NPHS1 NPHS1 adhesion molecule, nephrin multiple interactions ISO Losartan inhibits the reaction [AGT protein results in decreased expression of NPHS1 protein] CTD PMID:28578904 NCBI chr19:35,862,915...35,869,287
Ensembl chr19:35,825,964...35,869,287
JBrowse link
G NPHS2 NPHS2 stomatin family member, podocin multiple interactions EXP [Losartan co-treated with ICG 001] inhibits the reaction [AGT protein results in decreased expression of NPHS2 protein] CTD PMID:28578904 NCBI chr 1:179,550,539...179,575,987
Ensembl chr 1:179,550,539...179,575,952
JBrowse link
G NPPA natriuretic peptide A multiple interactions
decreases expression
ISO Losartan inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPA mRNA]
Losartan results in decreased expression of NPPA protein
CTD PMID:12198334 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345
JBrowse link
G NPPB natriuretic peptide B multiple interactions
decreases expression
ISO [Atenolol co-treated with Losartan co-treated with Doxazosin] results in decreased expression of NPPB mRNA; [Losartan co-treated with Doxazosin] results in decreased expression of NPPB mRNA; [Losartan co-treated with Nifedipine] results in decreased expression of NPPB mRNA; Losartan inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPB mRNA]
Losartan results in decreased expression of NPPB mRNA; Losartan results in decreased expression of NPPB protein
CTD PMID:12198334 PMID:15969258 PMID:17666919 NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945
JBrowse link
G NPR1 natriuretic peptide receptor 1 affects response to substance ISO NPR1 protein mutant form affects the susceptibility to Losartan CTD PMID:20881240 NCBI chr 1:153,678,649...153,693,992
Ensembl chr 1:153,678,688...153,693,992
JBrowse link
G NR1H3 nuclear receptor subfamily 1 group H member 3 increases expression ISO Losartan results in increased expression of NR1H3 protein CTD PMID:28091615 NCBI chr11:47,248,300...47,269,033
Ensembl chr11:47,248,300...47,269,033
JBrowse link
G NRF1 nuclear respiratory factor 1 increases expression ISO Losartan results in increased expression of NRF1 mRNA CTD PMID:18765277 NCBI chr 7:129,611,720...129,757,076
Ensembl chr 7:129,611,720...129,757,082
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased activity of PARP1 protein]
Losartan inhibits the reaction [AGT protein results in increased expression of PARP1 protein]
CTD PMID:15502880 PMID:21613793 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154
JBrowse link
G PDGFA platelet derived growth factor subunit A multiple interactions ISO Losartan inhibits the reaction [AGT protein alternative form results in increased expression of PDGFA mRNA alternative form] CTD PMID:12431451 NCBI chr 7:497,245...520,668
Ensembl chr 7:497,258...520,296
JBrowse link
G PDGFB platelet derived growth factor subunit B multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of PDGFB mRNA]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein] CTD PMID:12930639 PMID:17043664 NCBI chr22:39,223,359...39,244,982
Ensembl chr22:39,223,359...39,244,982
JBrowse link
G PDGFD platelet derived growth factor D multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of PDGFD mRNA] CTD PMID:17043664 NCBI chr11:103,907,189...104,164,147
Ensembl chr11:103,907,189...104,164,379
JBrowse link
G PDGFRB platelet derived growth factor receptor beta multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of PDGFRB mRNA] CTD PMID:17043664 NCBI chr 5:150,113,839...150,155,845
Ensembl chr 5:150,113,839...150,155,872
JBrowse link
G PDLIM3 PDZ and LIM domain 3 decreases expression ISO Losartan results in decreased expression of PDLIM3 mRNA CTD PMID:15100363 NCBI chr 4:185,500,660...185,535,507
Ensembl chr 4:185,500,660...185,535,507
JBrowse link
G PECAM1 platelet and endothelial cell adhesion molecule 1 decreases expression ISO Losartan results in decreased expression of PECAM1 mRNA CTD PMID:19771429 NCBI chr17:64,319,415...64,413,844
Ensembl chr17:64,319,415...64,413,776
JBrowse link
G PLAT plasminogen activator, tissue type decreases expression ISO Losartan results in decreased expression of PLAT mRNA CTD PMID:15100363 NCBI chr 8:42,174,718...42,207,565
Ensembl chr 8:42,174,718...42,207,709
JBrowse link
G PODXL podocalyxin like multiple interactions ISO Losartan inhibits the reaction [AGT protein results in decreased expression of PODXL protein] CTD PMID:28578904 NCBI chr 7:131,500,271...131,556,628
Ensembl chr 7:131,500,262...131,558,217
JBrowse link
G POSTN periostin multiple interactions
decreases expression
ISO Losartan inhibits the reaction [AGT protein results in increased expression of POSTN mRNA]
Losartan results in decreased expression of POSTN mRNA
CTD PMID:15121739 PMID:21641384 NCBI chr13:37,562,585...37,598,839
Ensembl chr13:37,562,583...37,598,844
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of PPARA mRNA] CTD PMID:19109942 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of PPARG mRNA]
Losartan inhibits the reaction [[Dietary Fats co-treated with Cholesterol] results in increased expression of PPARG mRNA]
CTD PMID:18302760 PMID:19109942 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha multiple interactions
increases expression
ISO Losartan inhibits the reaction [AGT protein results in increased expression of PPARGC1A mRNA]
Losartan results in increased expression of PPARGC1A mRNA
CTD PMID:18765277 PMID:18971572 PMID:19109942 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
JBrowse link
G PRKCB protein kinase C beta multiple interactions ISO Losartan inhibits the reaction [Ethanol results in increased expression of PRKCB protein] CTD PMID:22497828 NCBI chr16:23,835,983...24,220,611
Ensembl chr16:23,835,983...24,220,611
JBrowse link
G PRL prolactin multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased secretion of PRL protein] CTD PMID:14722030 NCBI chr 6:22,287,246...22,302,897
Ensembl chr 6:22,287,244...22,302,826
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
ISO
EXP
Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [Phenylephrine results in increased expression of PTGS2 mRNA]; Losartan inhibits the reaction [Phenylephrine results in increased expression of PTGS2 protein]
Losartan inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]
Losartan results in decreased expression of PTGS2 mRNA; Losartan results in decreased expression of PTGS2 protein
CTD PMID:17244722 PMID:18267125 PMID:21377515 PMID:28578904 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G PTH1R parathyroid hormone 1 receptor multiple interactions ISO Losartan inhibits the reaction [Folic Acid results in decreased expression of PTH1R protein]; Losartan inhibits the reaction [Gentamicins results in decreased expression of PTH1R protein] CTD PMID:15728788 NCBI chr 3:46,877,689...46,903,799
Ensembl chr 3:46,877,721...46,903,799
JBrowse link
G PTHLH parathyroid hormone like hormone multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of PTHLH mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PTHLH protein]; Losartan inhibits the reaction [Folic Acid results in increased expression of PTHLH mRNA]; Losartan inhibits the reaction [Folic Acid results in increased expression of PTHLH protein]; Losartan inhibits the reaction [Gentamicins results in increased expression of PTHLH protein] CTD PMID:15728788 NCBI chr12:27,958,084...27,972,864
Ensembl chr12:27,958,084...27,972,733
JBrowse link
G REG3G regenerating family member 3 gamma multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of REG3G mRNA] CTD PMID:27798352 NCBI chr 2:79,025,664...79,028,502
Ensembl chr 2:79,025,686...79,028,505
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO Losartan inhibits the reaction [Doxorubicin results in increased expression of RELA mRNA]
Losartan inhibits the reaction [AGT protein results in increased expression of RELA protein]; Losartan inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of RELA protein]
CTD PMID:15157388 PMID:28578904 PMID:29859236 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G REN renin multiple interactions
increases expression
increases activity
EXP
ISO
[Losartan results in decreased activity of AGTR1 protein] which results in increased expression of REN protein; Losartan inhibits the reaction [AGT protein results in increased expression of REN protein]; Losartan promotes the reaction [Hydrochlorothiazide results in increased expression of REN protein]
Losartan inhibits the reaction [AGT protein results in increased expression of REN1 protein]
Losartan results in increased expression of REN mRNA; Losartan results in increased expression of REN protein
Losartan results in increased activity of REN protein
[Lisinopril co-treated with Losartan] results in increased expression of REN mRNA; Losartan inhibits the reaction [Ethanol results in increased activity of REN protein]; Losartan promotes the reaction [Isoproterenol results in increased expression of REN protein]
CTD PMID:1387008 PMID:7965263 PMID:8382237 PMID:8403307 PMID:9124547 PMID:9245700 PMID:9431853 PMID:9533614 PMID:11709406 PMID:12013499 PMID:12569265 PMID:16221218 PMID:22982071 PMID:28578904 NCBI chr 1:204,154,819...204,166,337
Ensembl chr 1:204,154,819...204,190,324
JBrowse link
G RUNX2 RUNX family transcription factor 2 multiple interactions ISO Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 mRNA]; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 protein] CTD PMID:27412937 NCBI chr 6:45,328,330...45,551,082
Ensembl chr 6:45,328,157...45,664,349
JBrowse link
G S100A4 S100 calcium binding protein A4 multiple interactions EXP [Losartan co-treated with ICG 001] inhibits the reaction [AGT protein results in increased expression of S100A4 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of S100A4 protein] CTD PMID:28578904 NCBI chr 1:153,543,621...153,545,806
Ensembl chr 1:153,543,613...153,550,136
JBrowse link
G S1PR1 sphingosine-1-phosphate receptor 1 multiple interactions ISO Losartan inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 mRNA]; Losartan inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 protein] CTD PMID:29609002 NCBI chr 1:101,236,899...101,241,518
Ensembl chr 1:101,236,865...101,243,713
JBrowse link
G SCARB1 scavenger receptor class B member 1 multiple interactions ISO Losartan inhibits the reaction [[Dietary Fats co-treated with Cholesterol] results in decreased expression of SCARB1 mRNA] CTD PMID:18302760 NCBI chr12:124,776,856...124,863,864
Ensembl chr12:124,776,856...124,882,668
JBrowse link
G SDC2 syndecan 2 decreases expression ISO Losartan results in decreased expression of SDC2 mRNA; Losartan results in decreased expression of SDC2 protein CTD PMID:15100363 NCBI chr 8:96,493,601...96,611,790
Ensembl chr 8:96,493,813...96,611,790
JBrowse link
G SELP selectin P multiple interactions ISO Losartan inhibits the reaction [Estrogens deficiency results in increased expression of SELP protein] CTD PMID:19553526 NCBI chr 1:169,588,849...169,630,125
Ensembl chr 1:169,588,849...169,630,193
JBrowse link
G SFRP2 secreted frizzled related protein 2 decreases response to substance ISO SFRP2 protein results in decreased susceptibility to Losartan CTD PMID:23875703 NCBI chr 4:153,780,591...153,789,083
Ensembl chr 4:153,780,591...153,789,083
JBrowse link
G SLC22A12 solute carrier family 22 member 12 decreases activity
affects response to substance
decreases expression
multiple interactions
EXP Losartan results in decreased activity of SLC22A12 protein
SLC22A12 protein affects the susceptibility to Losartan
Losartan results in decreased expression of SLC22A12 mRNA
[Losartan results in decreased activity of SLC22A12 protein] which results in decreased abundance of Uric Acid
CTD PMID:18670416 PMID:20486468 NCBI chr11:64,591,219...64,603,250
Ensembl chr11:64,590,641...64,602,353
JBrowse link
G SLC22A9 solute carrier family 22 member 9 multiple interactions EXP Losartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate] CTD PMID:17132213 NCBI chr11:63,368,871...63,410,878
Ensembl chr11:63,369,785...63,410,294
JBrowse link
G SLC2A9 solute carrier family 2 member 9 multiple interactions ISO Losartan inhibits the reaction [SLC2A9 protein results in increased uptake of Uric Acid] CTD PMID:19587147 NCBI chr 4:9,771,125...10,040,270
Ensembl chr 4:9,771,153...10,054,936
JBrowse link
G SLC9A3 solute carrier family 9 member A3 multiple interactions ISO Losartan inhibits the reaction [Ammonium Chloride results in increased expression of NHE3 protein] CTD PMID:18287403 NCBI chr 5:470,456...524,449
Ensembl chr 5:470,456...524,449
JBrowse link
G SNAI1 snail family transcriptional repressor 1 multiple interactions EXP ICG 001 promotes the reaction [Losartan inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]]; Losartan inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]] CTD PMID:28578904 NCBI chr20:49,982,980...49,988,886
Ensembl chr20:49,982,980...49,988,886
JBrowse link
G SOD2 superoxide dismutase 2 decreases activity ISO Losartan results in decreased activity of SOD2 protein CTD PMID:18765277 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SOD3 superoxide dismutase 3 multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of SOD3 protein] CTD PMID:10400907 NCBI chr 4:24,795,478...24,800,845
Ensembl chr 4:24,789,912...24,800,842
JBrowse link
G SPARC secreted protein acidic and cysteine rich decreases expression ISO Losartan results in decreased expression of SPARC mRNA CTD PMID:15100363 NCBI chr 5:151,661,096...151,686,915
Ensembl chr 5:151,661,096...151,686,975
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of SREBF1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of SREBF1 protein] CTD PMID:19109942 PMID:25398788 NCBI chr17:17,811,334...17,837,017
Ensembl chr17:17,810,399...17,837,002
JBrowse link
G STAT3 signal transducer and activator of transcription 3 decreases phosphorylation EXP
ISO
Losartan results in decreased phosphorylation of STAT3 protein CTD PMID:33380422 NCBI chr17:42,313,324...42,388,502
Ensembl chr17:42,313,324...42,388,540
JBrowse link
G TGFB1 transforming growth factor beta 1 decreases secretion
multiple interactions
decreases activity
decreases expression
increases expression
EXP
ISO
Losartan results in decreased secretion of TGFB1 protein
Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of TGFB1 protein]
[Losartan results in decreased activity of AGT protein] which results in decreased activity of TGFB1 protein
Losartan results in decreased expression of TGFB1 mRNA; Losartan results in decreased expression of TGFB1 protein
Losartan results in increased expression of TGFB1 protein
[Losartan co-treated with Cilazapril] inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; [Losartan co-treated with Nifedipine] results in decreased expression of TGFB1 mRNA; Losartan inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased secretion of TGFB1 protein]; Losartan inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; Losartan inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]
CTD PMID:11369837 PMID:12930639 PMID:12937228 PMID:15331931 PMID:15573910 PMID:16191423 PMID:17330452 PMID:17666919 PMID:17784886 PMID:21152098 PMID:25233898 PMID:29859236 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 multiple interactions
decreases expression
ISO Losartan inhibits the reaction [Paraquat results in increased expression of TIMP1 mRNA]; Losartan inhibits the reaction [Simvastatin results in decreased expression of TIMP1 mRNA]; Simvastatin inhibits the reaction [Losartan results in decreased expression of TIMP1 mRNA] CTD PMID:20137537 PMID:25233898 NCBI chr  X:47,582,408...47,586,789
Ensembl chr  X:47,582,408...47,586,789
JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 decreases expression
multiple interactions
ISO Losartan results in decreased expression of TIMP2 mRNA
Losartan inhibits the reaction [Simvastatin results in decreased expression of TIMP2 mRNA]; Simvastatin inhibits the reaction [Losartan results in decreased expression of TIMP2 mRNA]
CTD PMID:20137537 NCBI chr17:78,852,977...78,925,387
Ensembl chr17:78,852,977...78,925,387
JBrowse link
G TJP1 tight junction protein 1 decreases expression ISO Losartan results in decreased expression of TJP1 protein CTD PMID:18400868 NCBI chr15:29,699,367...29,969,049
Ensembl chr15:29,699,367...29,968,915
JBrowse link
G TNC tenascin C decreases expression ISO Losartan results in decreased expression of TNC mRNA CTD PMID:15100363 NCBI chr 9:115,019,575...115,118,244
Ensembl chr 9:115,019,575...115,118,257
JBrowse link
G TNF tumor necrosis factor multiple interactions
decreases expression
EXP
ISO
Losartan affects the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Losartan inhibits the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]; Losartan inhibits the reaction [AGT protein modified form promotes the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]]; Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Losartan inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Losartan inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; T 0070907 inhibits the reaction [Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]
Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of TNF protein]
Losartan results in decreased expression of TNF protein
Losartan inhibits the reaction [bisphenol A results in increased expression of TNF mRNA]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased secretion of TNF protein]
CTD PMID:15573910 PMID:17299153 PMID:18060435 PMID:22124178 PMID:23875703 PMID:29859236 PMID:30677511 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TOMM20 translocase of outer mitochondrial membrane 20 decreases expression ISO Losartan results in decreased expression of TOMM20 mRNA CTD PMID:18765277 NCBI chr 1:235,109,341...235,128,837
Ensembl chr 1:235,109,341...235,128,837
JBrowse link
G TP53 tumor protein p53 affects expression ISO Losartan affects the expression of TP53 protein CTD PMID:22000973 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TSC22D1 TSC22 domain family member 1 multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of TSC22D1 mRNA] CTD PMID:26464165 NCBI chr13:44,432,143...44,576,825
Ensembl chr13:44,432,143...44,577,147
JBrowse link
G TWIST1 twist family bHLH transcription factor 1 multiple interactions ISO
EXP
Losartan inhibits the reaction [AGT protein results in increased expression of TWIST1 protein] CTD PMID:28578904 NCBI chr 7:19,113,047...19,117,636
Ensembl chr 7:19,020,991...19,117,636
JBrowse link
G UCP2 uncoupling protein 2 decreases expression
multiple interactions
ISO Losartan results in decreased expression of UCP2 mRNA; Losartan results in decreased expression of UCP2 protein
Losartan inhibits the reaction [AGT protein results in increased expression of UCP2 mRNA]
CTD PMID:17508912 PMID:19109942 NCBI chr11:73,974,671...73,983,202
Ensembl chr11:73,974,672...73,982,843
JBrowse link
G UCP3 uncoupling protein 3 multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of UCP3 mRNA] CTD PMID:19109942 NCBI chr11:74,000,277...74,009,085
Ensembl chr11:74,000,277...74,009,085
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions ISO Losartan inhibits the reaction [Estrogens deficiency results in increased expression of VCAM1 protein] CTD PMID:19553526 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions
decreases expression
EXP
ISO
Losartan inhibits the reaction [IL1A protein results in increased expression of VEGFA mRNA]; Losartan inhibits the reaction [IL1A protein results in increased expression of VEGFA protein]; Losartan inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Losartan inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; Losartan promotes the reaction [AGT protein results in increased expression of VEGFA mRNA]; Losartan promotes the reaction [AGT protein results in increased secretion of VEGFA protein]
Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of VEGFA protein]; Losartan inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]
Losartan inhibits the reaction [Cyclosporine results in increased expression of VEGFA protein]
Losartan results in decreased expression of VEGFA mRNA; Losartan results in decreased expression of VEGFA protein
CTD PMID:12110003 PMID:17299153 PMID:17481528 PMID:22188725 PMID:25511041 PMID:29859236 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
G VEGFC vascular endothelial growth factor C decreases expression ISO Losartan results in decreased expression of VEGFC mRNA CTD PMID:19771429 NCBI chr 4:176,683,538...176,792,922
Ensembl chr 4:176,683,538...176,792,922
JBrowse link
G VIM vimentin multiple interactions EXP
ISO
Losartan inhibits the reaction [AGT protein results in increased expression of VIM protein]
Losartan inhibits the reaction [AGT protein results in increased expression of VIM protein]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein]
CTD PMID:28578904 PMID:33007385 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593
JBrowse link
G WNT1 Wnt family member 1 multiple interactions ISO
EXP
Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 protein] CTD PMID:28578904 NCBI chr12:48,978,322...48,982,620
Ensembl chr12:48,978,322...48,982,620
JBrowse link
G WT1 WT1 transcription factor multiple interactions ISO Losartan inhibits the reaction [AGT protein results in decreased expression of WT1 protein] CTD PMID:28578904 NCBI chr11:32,387,775...32,435,539
Ensembl chr11:32,387,775...32,435,564
JBrowse link
losartan carboxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC22A9 solute carrier family 22 member 9 multiple interactions EXP losartan carboxylic acid inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate] CTD PMID:17132213 NCBI chr11:63,368,871...63,410,878
Ensembl chr11:63,369,785...63,410,294
JBrowse link
macitentan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 decreases expression EXP macitentan results in decreased expression of ABCB1 mRNA CTD PMID:28369585 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 decreases expression EXP macitentan results in decreased expression of ABCC2 mRNA CTD PMID:28369585 NCBI chr10:99,782,602...99,853,741
Ensembl chr10:99,782,640...99,852,594
JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 decreases expression EXP macitentan results in decreased expression of ABCC3 mRNA CTD PMID:28369585 NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253
JBrowse link
G SLC10A1 solute carrier family 10 member 1 decreases expression EXP macitentan results in decreased expression of SLC10A1 mRNA CTD PMID:28369585 NCBI chr14:69,775,416...69,797,241
Ensembl chr14:69,775,416...69,797,241
JBrowse link
PD123319 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE2 angiotensin converting enzyme 2 multiple interactions ISO PD 123319 inhibits the reaction [diminazene aceturate results in increased expression of ACE2 protein] CTD PMID:28688122 NCBI chr  X:15,518,197...15,607,211
Ensembl chr  X:15,494,566...15,607,236
JBrowse link
G AGT angiotensinogen multiple interactions
decreases response to substance
decreases activity
EXP
ISO
[olmesartan co-treated with PD 123319] inhibits the reaction [AGT protein modified form results in increased abundance of Fatty Acids, Nonesterified]; [olmesartan co-treated with PD 123319] inhibits the reaction [AGT protein modified form results in increased secretion of and results in increased abundance of Triglycerides]; PD 123319 inhibits the reaction [AGT protein results in increased expression of MDM2 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of MDM2 protein]
PD 123319 results in decreased susceptibility to AGT protein
PD 123319 results in decreased activity of AGT protein modified form
PD 123319 affects the reaction [AGT protein promotes the reaction [PTPN6 protein binds to MTUS1 protein]]; PD 123319 inhibits the reaction [AGT protein results in increased abundance of Nitric Oxide]; PD 123319 inhibits the reaction [AGT protein results in increased expression of ANGPT1 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of ANGPT2 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of EDN1 protein]; PD 123319 inhibits the reaction [AGT protein results in increased expression of KDR mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of MAP2 protein]; PD 123319 inhibits the reaction [AGT protein results in increased expression of SPP1 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of SPP1 protein]; PD 123319 inhibits the reaction [AGT protein results in increased expression of TEK mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of TUBB3 protein]; PD 123319 inhibits the reaction [AGT protein results in increased expression of UBE2V2 protein]; PD 123319 inhibits the reaction [AGT protein results in increased expression of VEGFA mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of VEGFA protein]; PD 123319 promotes the reaction [AGT protein results in increased abundance of Prostaglandins E]
PD 123319 inhibits the reaction [AGT protein results in increased expression of UBE2V2 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of UBE2V2 protein]; PD 123319 inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; PD 123319 inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 protein]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX2 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX2 protein]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX4 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP mRNA]]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP protein]]]; PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [[AGT protein co-treated with Rotenone] results in increased expression of AGTR2 protein]]; PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTR2 mRNA]]]
CTD PMID:9176287 PMID:9519251 PMID:11115077 PMID:14597853 PMID:14638905 PMID:14718351 PMID:15007106 PMID:16003179 PMID:16769992 PMID:17068200 PMID:18206046 PMID:18300857 PMID:19041135 PMID:19246637 PMID:25446015 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576
JBrowse link
G AGTR2 angiotensin II receptor type 2 multiple interactions
decreases activity
increases expression
decreases expression
EXP
ISO
[PD 123319 binds to and results in decreased activity of AGTR2 protein] inhibits the reaction [candesartan results in increased expression of NOS3 protein]; PD 123319 binds to and results in decreased activity of AGTR2 protein
PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [[AGT protein co-treated with Rotenone] results in increased expression of AGTR2 protein]]; PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTR2 mRNA]]]
PD 123319 results in decreased activity of AGTR2 protein
PD 123319 results in increased expression of AGTR2 mRNA; PD 123319 results in increased expression of AGTR2 protein
PD 123319 results in decreased expression of AGTR2 mRNA
[PD 123319 binds to and results in decreased activity of AGTR2 protein] which affects the susceptibility to Phenylephrine; [PD 123319 results in decreased activity of AGTR2 protein] inhibits the reaction [Valsartan results in increased abundance of Cyclic GMP]; [PD 123319 results in decreased activity of AGTR2 protein] which results in decreased susceptibility to Estradiol; [PD 123319 results in decreased activity of AGTR2 protein] which results in decreased susceptibility to Valsartan; PD 123319 binds to and results in decreased activity of AGTR2 protein
CTD PMID:9336375 PMID:9740612 PMID:11509473 PMID:11893553 PMID:15807884 PMID:16982965 PMID:18300857 PMID:18388195 PMID:18551021 PMID:19151255 PMID:25446015 NCBI chr  X:116,170,744...116,174,974
Ensembl chr  X:116,170,744...116,174,974
JBrowse link
G AGTRAP angiotensin II receptor associated protein multiple interactions ISO PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP mRNA]]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP protein]]] CTD PMID:25446015 NCBI chr 1:11,736,121...11,750,771
Ensembl chr 1:11,736,084...11,754,802
JBrowse link
G ANGPT1 angiopoietin 1 multiple interactions ISO PD 123319 inhibits the reaction [AGT protein results in increased expression of ANGPT1 mRNA] CTD PMID:14638905 NCBI chr 8:107,249,482...107,497,918
Ensembl chr 8:107,249,482...107,498,055
JBrowse link
G ANGPT2 angiopoietin 2 multiple interactions ISO PD 123319 inhibits the reaction [AGT protein results in increased expression of ANGPT2 mRNA] CTD PMID:14638905 NCBI chr 8:6,499,632...6,563,245
Ensembl chr 8:6,499,632...6,563,409
JBrowse link
G BDKRB2 bradykinin receptor B2 multiple interactions ISO PD 123319 affects the reaction [BDKRB2 affects the abundance of 6-Ketoprostaglandin F1 alpha] CTD PMID:16514058 NCBI chr14:96,204,839...96,244,164
Ensembl chr14:96,204,679...96,244,166
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions ISO PD 123319 inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA] CTD PMID:15284299 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CCL5 C-C motif chemokine ligand 5 multiple interactions ISO PD 123319 inhibits the reaction [Ethylene Glycol results in increased expression of CCL5 protein] CTD PMID:16284884 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793
JBrowse link
G CYBB cytochrome b-245 beta chain multiple interactions ISO PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX2 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX2 protein]] CTD PMID:25446015 NCBI chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,059...37,813,461
JBrowse link
G EDN1 endothelin 1 multiple interactions ISO PD 123319 inhibits the reaction [AGT protein results in increased expression of EDN1 protein] CTD PMID:15007106 NCBI chr 6:12,256,463...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G JAK2 Janus kinase 2 multiple interactions EXP PD123319 co-treated with losartan inhibits the reaction [Angiotensin II increases phosphorylation of JAK2 protein in liver] RGD PMID:22613986 RGD:127285667 NCBI chr 9:4,984,390...5,129,948
Ensembl chr 9:4,984,390...5,129,948
JBrowse link
G KDR kinase insert domain receptor multiple interactions ISO PD 123319 inhibits the reaction [AGT protein results in increased expression of KDR mRNA] CTD PMID:14638905 NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595
JBrowse link
G KNG1 kininogen 1 multiple interactions ISO PD 123319 inhibits the reaction [benazepril promotes the reaction [Valsartan results in increased expression of KNG1 protein modified form]]; PD 123319 inhibits the reaction [Valsartan promotes the reaction [benazepril results in increased expression of KNG1 protein modified form]]
PD 123319 affects the reaction [KNG1 affects the abundance of Nitric Oxide]
CTD PMID:11509473 PMID:16514058 NCBI chr 3:186,717,359...186,744,410
Ensembl chr 3:186,717,348...186,744,410
JBrowse link
G MAP2 microtubule associated protein 2 multiple interactions ISO PD 123319 inhibits the reaction [AGT protein results in increased expression of MAP2 protein] CTD PMID:17068200 NCBI chr 2:209,424,047...209,734,118
Ensembl chr 2:209,424,047...209,734,118
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO PD 123319 inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein] CTD PMID:19041135 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO PD 123319 inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein] CTD PMID:19041135 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MDM2 MDM2 proto-oncogene multiple interactions EXP PD 123319 inhibits the reaction [AGT protein results in increased expression of MDM2 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of MDM2 protein] CTD PMID:18206046 NCBI chr12:68,808,149...68,850,686
Ensembl chr12:68,808,177...68,845,544
JBrowse link
G MTUS1 microtubule associated scaffold protein 1 multiple interactions ISO PD 123319 affects the reaction [AGT protein promotes the reaction [PTPN6 protein binds to MTUS1 protein]] CTD PMID:17068200 NCBI chr 8:17,643,794...17,801,521
Ensembl chr 8:17,643,795...17,800,917
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions ISO PD 123319 inhibits the reaction [Ethylene Glycol results in increased expression of NFKB1 protein] CTD PMID:16284884 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302
JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions EXP [PD 123319 binds to and results in decreased activity of AGTR2 protein] inhibits the reaction [candesartan results in increased expression of NOS3 protein] CTD PMID:18551021 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
JBrowse link
G NOX1 NADPH oxidase 1 multiple interactions ISO PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 protein]] CTD PMID:25446015 NCBI chr  X:100,843,324...100,874,359
Ensembl chr  X:100,843,324...100,874,359
JBrowse link
G NOX4 NADPH oxidase 4 multiple interactions ISO PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX4 mRNA]] CTD PMID:25446015 NCBI chr11:89,324,353...89,589,557
Ensembl chr11:89,324,353...89,498,187
JBrowse link
G PRKCE protein kinase C epsilon increases expression ISO PD 123319 results in increased expression of PRKCE protein CTD PMID:11893553 NCBI chr 2:45,651,315...46,187,990
Ensembl chr 2:45,651,345...46,187,990
JBrowse link
G PTPN6 protein tyrosine phosphatase non-receptor type 6 multiple interactions ISO PD 123319 affects the reaction [AGT protein promotes the reaction [PTPN6 protein binds to MTUS1 protein]] CTD PMID:17068200 NCBI chr12:6,946,577...6,961,316
Ensembl chr12:6,946,468...6,961,316
JBrowse link
G SPP1 secreted phosphoprotein 1 multiple interactions ISO PD 123319 inhibits the reaction [AGT protein results in increased expression of SPP1 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of SPP1 protein] CTD PMID:11115077 NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,667...87,983,532
JBrowse link
G TEK TEK receptor tyrosine kinase multiple interactions ISO PD 123319 inhibits the reaction [AGT protein results in increased expression of TEK mRNA] CTD PMID:14638905 NCBI chr 9:27,109,141...27,230,178
Ensembl chr 9:27,109,141...27,230,174
JBrowse link
G TUBB3 tubulin beta 3 class III multiple interactions ISO PD 123319 inhibits the reaction [AGT protein results in increased expression of TUBB3 protein] CTD PMID:17068200 NCBI chr16:89,921,925...89,936,097
Ensembl chr16:89,921,392...89,938,761
JBrowse link
G UBE2V2 ubiquitin conjugating enzyme E2 V2 multiple interactions ISO PD 123319 inhibits the reaction [AGT protein results in increased expression of UBE2V2 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of UBE2V2 protein] CTD PMID:16769992 PMID:17068200 NCBI chr 8:47,997,527...48,064,708
Ensembl chr 8:48,008,415...48,064,708
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions ISO PD 123319 inhibits the reaction [AGT protein results in increased expression of VEGFA mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of VEGFA protein]; PD 123319 inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]; PD 123319 inhibits the reaction [Streptozocin results in increased expression of VEGFA protein] CTD PMID:14638905 PMID:14718351 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24830
    role 24747
      biological role 24716
        pharmacological role 21260
          antagonist 17311
            hormone antagonist 11312
              endothelin receptor antagonist 263
                ACT-132577 + 4
                PD123319 30
                bosentan + 95
                endothelin A receptor antagonist 0
                enrasentan 2
                losartan + 170
                macitentan 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 24830
    role 24747
      application 23892
        pharmaceutical 23495
          drug 23495
            receptor modulator 21292
              hormone receptor modulator 21237
                hormone antagonist 11312
                  endothelin receptor antagonist 263
                    ACT-132577 + 4
                    PD123319 30
                    bosentan + 95
                    endothelin A receptor antagonist 0
                    enrasentan 2
                    losartan + 170
                    macitentan 4
paths to the root