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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:endothelin receptor antagonist
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Accession:CHEBI:51451 term browser browse the term
Definition:A hormone antagonist that blocks endothelin receptors.
Synonyms:related_synonym: ERA

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bosentan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
decreases expression
multiple interactions		 EXP
ISO		 bosentan metabolite results in decreased activity of ABCB11 protein; bosentan results in decreased activity of ABCB11 protein
Bosentan results in decreased expression of ABCB11 mRNA
bosentan results in decreased expression of ABCB11 mRNA
bosentan inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]		 CTD PMID:11309550 PMID:15465654 PMID:15509663 PMID:20829430 PMID:23956101 PMID:24014644 PMID:27765674 PMID:29761207 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression ISO bosentan results in decreased expression of ABCB1 mRNA CTD PMID:28369585 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression ISO Bosentan results in decreased expression of ABCB4 mRNA CTD PMID:29761207 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression
decreases expression		 EXP
ISO		 bosentan results in increased expression of ABCC2 mRNA
Bosentan results in increased expression of ABCC2 mRNA
bosentan results in decreased expression of ABCC2 mRNA		 CTD PMID:27765674 PMID:28369585 PMID:29761207 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression
decreases expression		 EXP
ISO		 bosentan results in increased expression of ABCC3 mRNA
bosentan results in decreased expression of ABCC3 mRNA		 CTD PMID:27765674 PMID:28369585 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases expression EXP bosentan results in increased expression of ABCC4 mRNA CTD PMID:27765674 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression
affects expression		 EXP
ISO		 bosentan results in increased expression of ABCG5 mRNA
Bosentan affects the expression of ABCG5 mRNA		 CTD PMID:27765674 PMID:29761207 NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207 		JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 increases expression EXP bosentan results in increased expression of ABCG8 mRNA CTD PMID:27765674 NCBI chr 6:7,961,413...7,980,708
Ensembl chr 6:7,961,413...7,980,708 		JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) decreases expression ISO Bosentan results in decreased expression of ADH1C mRNA; Bosentan results in decreased expression of ADH1C protein CTD PMID:29761207 NCBI chr 2:243,550,655...243,562,243
Ensembl chr 2:243,550,627...243,687,857 		JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide decreases expression ISO Bosentan results in decreased expression of ADH4 mRNA; Bosentan results in decreased expression of ADH4 protein CTD PMID:29761207 NCBI chr 2:243,702,035...243,720,063
Ensembl chr 2:243,700,784...243,740,899 		JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO bosentan inhibits the reaction [EDN1 protein results in increased expression of ADRB2 mRNA] CTD PMID:22483689 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834 		JBrowse link
G Aldh8a1 aldehyde dehydrogenase 8 family, member A1 affects expression ISO Bosentan affects the expression of ALDH8A1 mRNA CTD PMID:29761207 NCBI chr 1:16,910,043...16,929,465
Ensembl chr 1:16,910,069...16,930,481 		JBrowse link
G Aldob aldolase, fructose-bisphosphate B decreases expression ISO Bosentan results in decreased expression of ALDOB mRNA; Bosentan results in decreased expression of ALDOB protein CTD PMID:29761207 NCBI chr 5:64,805,772...64,818,813
Ensembl chr 5:64,805,773...64,818,824 		JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 affects expression ISO Bosentan affects the expression of ASCL1 mRNA CTD PMID:29761207 NCBI chr 7:28,038,662...28,040,504
Ensembl chr 7:28,038,662...28,040,510 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO bosentan inhibits the reaction [Doxorubicin results in increased expression of BAX protein] CTD PMID:17974986 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G C9 complement C9 affects expression ISO Bosentan affects the expression of C9 mRNA CTD PMID:29761207 NCBI chr 2:55,775,562...55,823,807
Ensembl chr 2:55,775,274...55,823,826 		JBrowse link
G Ca12 carbonic anhydrase 12 affects expression ISO Bosentan affects the expression of CA12 mRNA CTD PMID:29761207 NCBI chr 8:72,405,770...72,461,425
Ensembl chr 8:72,405,748...72,460,240 		JBrowse link
G Cat catalase decreases expression ISO Bosentan results in decreased expression of CAT mRNA CTD PMID:29761207 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Col1a2 collagen type I alpha 2 chain decreases expression ISO bosentan results in decreased expression of COL1A2 protein CTD PMID:11729239 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151 		JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 decreases expression ISO Bosentan results in decreased expression of CPS1 mRNA; Bosentan results in decreased expression of CPS1 protein CTD PMID:29761207 NCBI chr 9:74,113,437...74,236,274
Ensembl chr 9:74,124,016...74,236,274 		JBrowse link
G Cxadr CXADR, Ig-like cell adhesion molecule decreases expression
multiple interactions		 ISO bosentan results in decreased expression of CXADR mRNA; bosentan results in decreased expression of CXADR protein
EDN1 protein inhibits the reaction [bosentan results in decreased expression of CXADR mRNA]		 CTD PMID:20392896 NCBI chr11:16,826,269...16,873,564
Ensembl chr11:16,826,399...16,873,562 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Bosentan results in increased expression of CYP2B6 mRNA CTD PMID:18332078 PMID:29761207 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615 		JBrowse link
G Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 affects expression ISO Bosentan affects the expression of CYP3A43 mRNA CTD PMID:29761207 NCBI chr12:10,636,294...10,684,273
Ensembl chr12:10,636,275...10,684,278 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO Bosentan results in decreased expression of CYP7A1 mRNA CTD PMID:29761207 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431 		JBrowse link
G Dclk1 doublecortin-like kinase 1 affects expression ISO Bosentan affects the expression of DCLK1 mRNA CTD PMID:29761207 NCBI chr 2:144,646,255...144,939,389
Ensembl chr 2:144,646,308...144,936,927 		JBrowse link
G Dlx6 distal-less homeobox 6 decreases expression ISO bosentan results in decreased expression of DLX6 mRNA CTD PMID:15063187 NCBI chr 4:32,373,096...32,377,388
Ensembl chr 4:32,373,641...32,377,253 		JBrowse link
G Edn1 endothelin 1 decreases activity
decreases expression
multiple interactions		 EXP
ISO		 bosentan results in decreased activity of EDN1 protein
bosentan results in decreased expression of EDN1 protein
bosentan inhibits the reaction [EDN1 protein results in increased expression of ADRB2 mRNA]; bosentan inhibits the reaction [Oxotremorine results in increased activity of EDN1 protein]; bosentan inhibits the reaction [TGFB1 protein results in increased activity of EDN1 protein]; EDN1 protein inhibits the reaction [bosentan results in decreased expression of CXADR mRNA]
3,5-dibromosalicylic acid inhibits the reaction [bosentan inhibits the reaction [EDN1 protein binds to EDNRA protein]]; bosentan binds to and results in decreased activity of EDN1 protein; bosentan inhibits the reaction [EDN1 protein binds to EDNRA protein]; bosentan inhibits the reaction [Monocrotaline results in increased expression of EDN1 mRNA]		 CTD PMID:10474778 PMID:10961375 PMID:11093786 PMID:16431896 PMID:20392896 PMID:20967148 PMID:22483689 PMID:22796455 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324 		JBrowse link
G Edn3 endothelin 3 decreases activity EXP bosentan results in decreased activity of EDN3 protein CTD PMID:10961375 NCBI chr 3:172,856,730...172,879,276
Ensembl chr 3:172,856,733...172,880,450 		JBrowse link
G Ednra endothelin receptor type A multiple interactions ISO
EXP		 bosentan binds to and results in decreased activity of EDNRA protein
3,5-dibromosalicylic acid inhibits the reaction [bosentan inhibits the reaction [EDN1 protein binds to EDNRA protein]]; bosentan binds to and results in decreased activity of EDNRA protein; bosentan inhibits the reaction [EDN1 protein binds to EDNRA protein]		 CTD PMID:11093786 PMID:15964565 PMID:16219361 NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703 		JBrowse link
G Ednrb endothelin receptor type B multiple interactions ISO bosentan binds to and results in decreased activity of EDNRB protein CTD PMID:16219361 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354 		JBrowse link
G Fabp1 fatty acid binding protein 1 decreases expression ISO Bosentan results in decreased expression of FABP1 mRNA; Bosentan results in decreased expression of FABP1 protein CTD PMID:29761207 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO bosentan inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; bosentan inhibits the reaction [Glucose results in increased expression of FN1 protein] CTD PMID:12388107 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078 		JBrowse link
G G0s2 G0/G1switch 2 affects expression ISO Bosentan affects the expression of G0S2 mRNA CTD PMID:29761207 NCBI chr13:112,004,140...112,005,052
Ensembl chr13:112,004,140...112,005,052 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 affects expression ISO Bosentan affects the expression of G6PC1 mRNA CTD PMID:29761207 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213 		JBrowse link
G Gata4 GATA binding protein 4 multiple interactions
affects activity		 ISO
EXP		 bosentan inhibits the reaction [Doxorubicin results in decreased expression of GATA4 mRNA]; bosentan inhibits the reaction [Doxorubicin results in decreased expression of GATA4 protein]
bosentan affects the activity of GATA4 protein		 CTD PMID:17974986 PMID:21084678 NCBI chr15:46,386,703...46,458,679
Ensembl chr15:46,386,712...46,432,965 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Bosentan results in increased expression of GCLC mRNA CTD PMID:29761207 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression ISO Bosentan results in decreased expression of GPX1 mRNA CTD PMID:29761207 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522 		JBrowse link
G Gstt2 glutathione S-transferase, theta 2 decreases expression ISO Bosentan results in decreased expression of GSTT2 mRNA CTD PMID:29761207 NCBI chr20:13,760,810...13,764,481
Ensembl chr20:13,760,810...13,764,475 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Bosentan results in increased expression of HMOX1 mRNA CTD PMID:29761207 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha decreases expression ISO Bosentan results in decreased expression of HNF4A mRNA CTD PMID:29761207 NCBI chr 3:159,902,441...159,965,003
Ensembl chr 3:159,902,441...159,965,003 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 affects expression ISO Bosentan affects the expression of HSD3B1 mRNA CTD PMID:29761207
G Igf1 insulin-like growth factor 1 affects expression ISO Bosentan affects the expression of IGF1 mRNA CTD PMID:29761207 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609 		JBrowse link
G Il6 interleukin 6 increases expression ISO Bosentan results in increased expression of IL6 mRNA CTD PMID:29761207 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Inhbe inhibin subunit beta E affects expression ISO Bosentan affects the expression of INHBE mRNA CTD PMID:29761207 NCBI chr 7:70,641,423...70,642,848
Ensembl chr 7:70,640,075...70,643,169 		JBrowse link
G Kmo kynurenine 3-monooxygenase affects expression ISO Bosentan affects the expression of KMO mRNA CTD PMID:29761207 NCBI chr13:93,684,324...93,715,378
Ensembl chr13:93,684,437...93,716,227 		JBrowse link
G MGC105649 hypothetical LOC302884 affects expression ISO Bosentan affects the expression of C15ORF48 mRNA CTD PMID:29761207 NCBI chr 3:114,772,603...114,776,156
Ensembl chr 3:114,772,603...114,776,155 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 decreases expression ISO Bosentan results in decreased expression of MGST1 mRNA CTD PMID:29761207 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607 		JBrowse link
G Mrc1 mannose receptor, C type 1 affects expression ISO Bosentan affects the expression of MRC1 mRNA CTD PMID:29761207 NCBI chr17:81,352,700...81,433,743
Ensembl chr17:81,352,700...81,433,743 		JBrowse link
G Mttp microsomal triglyceride transfer protein decreases expression ISO Bosentan results in decreased expression of MTTP mRNA CTD PMID:29761207 NCBI chr 2:243,366,181...243,407,608
Ensembl chr 2:243,366,181...243,407,608 		JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions ISO Bosentan inhibits the reaction [MYH7 gene mutant form results in increased expression of NPPB protein] CTD PMID:29741611 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089 		JBrowse link
G Nfix nuclear factor I X decreases expression ISO Bosentan results in decreased expression of NFIX mRNA CTD PMID:29761207 NCBI chr19:25,818,640...25,914,777
Ensembl chr19:25,821,780...25,914,696 		JBrowse link
G Nox4 NADPH oxidase 4 decreases expression ISO Bosentan results in decreased expression of NOX4 mRNA CTD PMID:29761207 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194 		JBrowse link
G Nppb natriuretic peptide B multiple interactions ISO Bosentan inhibits the reaction [MYH7 gene mutant form results in increased expression of NPPB protein] CTD PMID:29741611 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Bosentan results in increased expression of NQO1 mRNA CTD PMID:29761207 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 decreases expression ISO Bosentan results in decreased expression of NR1H2 mRNA CTD PMID:29761207 NCBI chr 1:100,554,577...100,559,896
Ensembl chr 1:100,554,544...100,559,942 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 decreases expression ISO Bosentan results in decreased expression of NR1H3 mRNA CTD PMID:29761207 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression ISO Bosentan results in decreased expression of NR1H4 mRNA CTD PMID:29761207 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056 		JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) decreases expression ISO Bosentan results in decreased expression of PCK2 mRNA CTD PMID:29761207 NCBI chr15:34,216,735...34,224,357
Ensembl chr15:34,216,833...34,224,193 		JBrowse link
G Pglyrp2 peptidoglycan recognition protein 2 affects expression ISO Bosentan affects the expression of PGLYRP2 mRNA CTD PMID:29761207 NCBI chr 7:14,426,481...14,435,987
Ensembl chr 7:14,429,701...14,435,967 		JBrowse link
G Pklr pyruvate kinase L/R affects expression ISO Bosentan affects the expression of PKLR mRNA CTD PMID:29761207 NCBI chr 2:188,449,158...188,458,034
Ensembl chr 2:188,449,210...188,459,592 		JBrowse link
G Pon1 paraoxonase 1 decreases expression ISO Bosentan results in decreased expression of PON1 mRNA CTD PMID:29761207 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372 		JBrowse link
G Por cytochrome p450 oxidoreductase affects expression ISO Bosentan affects the expression of POR mRNA CTD PMID:29761207 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO Bosentan results in decreased expression of PPARG mRNA CTD PMID:29761207 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression ISO Bosentan results in decreased expression of PPARGC1A mRNA CTD PMID:29761207 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO bosentan inhibits the reaction [Glucose results in increased activity of RELA protein] CTD PMID:12388107 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G RGD1564614 similar to complement factor H-related protein affects expression ISO Bosentan affects the expression of CFHR3 mRNA CTD PMID:29761207 NCBI chr13:56,889,669...56,958,549
Ensembl chr13:56,889,669...56,958,561 		JBrowse link
G Sftpa1 surfactant protein A1 multiple interactions EXP Bosentan inhibits the reaction [Nitric Oxide Donors results in decreased expression of SFTPA1 mRNA]; Bosentan inhibits the reaction [Nitric Oxide results in decreased expression of SFTPA1 mRNA]; Bosentan inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPA1 mRNA] CTD PMID:15640287 NCBI chr16:18,716,019...18,719,404
Ensembl chr16:18,716,019...18,719,403 		JBrowse link
G Sftpb surfactant protein B multiple interactions EXP bosentan inhibits the reaction [Nitric Oxide Donors results in decreased expression of SFTPB mRNA]; bosentan inhibits the reaction [Nitric Oxide results in decreased expression of SFTPB mRNA]; bosentan inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPB mRNA] CTD PMID:15640287 NCBI chr 4:100,166,855...100,175,941
Ensembl chr 4:100,166,863...100,175,938 		JBrowse link
G Sftpc surfactant protein C multiple interactions EXP bosentan inhibits the reaction [Nitric Oxide Donors results in decreased expression of SFTPC mRNA]; bosentan inhibits the reaction [Nitric Oxide results in decreased expression of SFTPC mRNA]; bosentan inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPC mRNA] CTD PMID:15640287 NCBI chr15:52,211,538...52,214,480
Ensembl chr15:52,211,544...52,214,616 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression EXP
ISO		 bosentan results in decreased expression of SLC10A1 mRNA
Bosentan results in decreased expression of SLC10A1 mRNA		 CTD PMID:27765674 PMID:28369585 PMID:29761207 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 affects expression ISO Bosentan affects the expression of SLC22A7 mRNA CTD PMID:29761207 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 increases expression ISO Bosentan results in increased expression of SLC3A2 mRNA; Bosentan results in increased expression of SLC3A2 protein CTD PMID:29761207 NCBI chr 1:224,906,566...224,921,029
Ensembl chr 1:224,906,554...224,921,092 		JBrowse link
G Slc51a solute carrier family 51 subunit alpha increases expression ISO Bosentan results in increased expression of SLC51A mRNA CTD PMID:29761207 NCBI chr11:71,533,078...71,547,476
Ensembl chr11:71,533,078...71,547,476 		JBrowse link
G Slc51b solute carrier family 51 subunit beta increases expression ISO Bosentan results in increased expression of SLC51B mRNA CTD PMID:29761207 NCBI chr 8:70,930,196...70,938,559
Ensembl chr 8:70,930,347...70,932,986 		JBrowse link
G Slc6a1 solute carrier family 6 member 1 affects expression ISO Bosentan affects the expression of SLC6A1 mRNA CTD PMID:29761207 NCBI chr 4:146,258,842...146,292,176
Ensembl chr 4:146,276,862...146,292,213 		JBrowse link
G Slco1a1 solute carrier organic anion transporter family, member 1a1 multiple interactions
increases uptake		 EXP [biochanin A results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [hispidulin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [isoliquiritigenin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [kaempferol results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [licochalcone A results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [Luteolin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [sinensetin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan
SLCO1B1 protein results in increased uptake of Bosentan		 CTD PMID:32259555 NCBI chr 4:176,158,174...176,231,331
Ensembl chr 4:176,158,640...176,231,344 		JBrowse link
G Sod1 superoxide dismutase 1 decreases expression ISO Bosentan results in decreased expression of SOD1 mRNA CTD PMID:29761207 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO Bosentan results in increased expression of SOD2 mRNA CTD PMID:29761207 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 affects expression ISO Bosentan affects the expression of SULT1E1 mRNA CTD PMID:29761207 NCBI chr14:22,070,861...22,089,264
Ensembl chr14:22,072,024...22,089,248 		JBrowse link
G Tat tyrosine aminotransferase affects expression ISO Bosentan affects the expression of TAT mRNA CTD PMID:29761207 NCBI chr19:41,675,639...41,686,195
Ensembl chr19:41,675,355...41,686,229 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO bosentan inhibits the reaction [TGFB1 protein results in increased activity of EDN1 protein] CTD PMID:22796455 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO bosentan inhibits the reaction [Doxorubicin results in increased expression of TNF protein] CTD PMID:17974986 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Txn2 thioredoxin 2 decreases expression ISO Bosentan results in decreased expression of TXN2 mRNA CTD PMID:29761207 NCBI chr 7:119,144,350...119,158,173
Ensembl chr 7:119,144,351...119,158,201 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Bosentan results in increased expression of TXNRD1 mRNA CTD PMID:29761207 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 decreases expression ISO Bosentan results in decreased expression of UGT1A6 mRNA CTD PMID:29761207 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Vnn1 vanin 1 affects expression ISO Bosentan affects the expression of VNN1 mRNA CTD PMID:29761207 NCBI chr 1:22,614,832...22,625,134
Ensembl chr 1:22,614,783...22,625,204 		JBrowse link
G Xdh xanthine dehydrogenase decreases expression ISO Bosentan results in decreased expression of XDH mRNA CTD PMID:29761207 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494 		JBrowse link
enrasentan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ednra endothelin receptor type A multiple interactions ISO enrasentan binds to and results in decreased activity of EDNRA protein CTD PMID:16219361 NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703 		JBrowse link
G Ednrb endothelin receptor type B multiple interactions ISO enrasentan binds to and results in decreased activity of EDNRB protein CTD PMID:16219361 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354 		JBrowse link
losartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions		 ISO Losartan results in decreased activity of ABCB11 protein
Losartan inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]		 CTD PMID:23956101 PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946 		JBrowse link
G Ace angiotensin I converting enzyme multiple interactions
decreases expression		 ISO
EXP		 Losartan inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of ACE protein]; Losartan inhibits the reaction [Oxygen deficiency results in increased expression of ACE protein]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of ACE mRNA]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of ACE protein]
Losartan results in decreased expression of ACE protein		 CTD PMID:25511041 PMID:25655897 PMID:28091615 PMID:28578904 PMID:33007385 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822 		JBrowse link
G Ace2 angiotensin I converting enzyme 2 multiple interactions
increases activity
increases expression		 EXP
ISO		 Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of ACE2 protein]
Losartan results in increased activity of ACE2 protein
Losartan results in increased expression of ACE2 protein
Losartan results in increased expression of ACE2 mRNA; Losartan results in increased expression of ACE2 protein
Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [Oxygen deficiency results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 protein]		 CTD PMID:15897343 PMID:16176966 PMID:16221218 PMID:20178811 PMID:22009550 PMID:25511041 PMID:25655897 PMID:28091615 PMID:33007385 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016 		JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions		 EXP
ISO		 Losartan results in decreased expression of ACTA2 mRNA; Losartan results in decreased expression of ACTA2 protein
Losartan inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]		 CTD PMID:15100363 PMID:28091615 PMID:28578904 PMID:33007385 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394 		JBrowse link
G Actg2 actin gamma 2, smooth muscle decreases expression EXP Losartan results in decreased expression of ACTG2 mRNA CTD PMID:15100363 NCBI chr 4:115,215,160...115,239,746
Ensembl chr 4:115,215,060...115,239,723 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO Losartan results in increased expression of ADIPOQ mRNA CTD PMID:19730415 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488 		JBrowse link
G Adrb2 adrenoceptor beta 2 affects expression EXP Losartan affects the expression of ADRB2 protein CTD PMID:9260993 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834 		JBrowse link
G Afp alpha-fetoprotein multiple interactions ISO Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein] CTD PMID:29859236 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923 		JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions EXP Losartan inhibits the reaction [Glucose promotes the reaction [Linoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]; Losartan inhibits the reaction [Linoleic Acid promotes the reaction [Glucose promotes the reaction [Azoxymethane results in increased expression of AGER protein]]] CTD PMID:22467055 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079 		JBrowse link
G Agt angiotensinogen multiple interactions
increases secretion
decreases activity
decreases response to substance
increases expression
decreases expression		 ISO
EXP		 [Losartan co-treated with ICG 001] inhibits the reaction [AGT protein results in decreased expression of NPHS2 protein]; [Losartan co-treated with ICG 001] inhibits the reaction [AGT protein results in increased expression of S100A4 protein]; [Losartan results in decreased activity of AGTR1 protein] which results in increased expression of AGT protein alternative form; ICG 001 promotes the reaction [Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]]; ICG 001 promotes the reaction [Losartan inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]]; Losartan inhibits the reaction [[AGT protein modified form co-treated with Ascorbic Acid co-treated with Copper Sulfate] results in increased chemical synthesis of [4-hydroxy-2-nonenal binds to AGT protein modified form]]; Losartan inhibits the reaction [[AGT protein modified form co-treated with Ascorbic Acid co-treated with Copper Sulfate] results in increased chemical synthesis of [pyruvamide binds to AGT protein modified form]]; Losartan inhibits the reaction [AGT protein affects the localization of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein modified form promotes the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]]; Losartan inhibits the reaction [AGT protein modified form results in decreased secretion of Nitric Oxide]; Losartan inhibits the reaction [AGT protein modified form results in increased expression of EDN1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of HMOX1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of NFE2L2 protein]; Losartan inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; Losartan inhibits the reaction [AGT protein results in increased expression of ACE protein]; Losartan inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGT protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; Losartan inhibits the reaction [AGT protein results in increased expression of and results in increased activity of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CCL2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of REN protein]; Losartan inhibits the reaction [AGT protein results in increased expression of S100A4 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of TWIST1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of VIM protein]; Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 protein]; Losartan inhibits the reaction [AGT protein results in increased secretion of ICAM1 protein]; Losartan promotes the reaction [AGT protein results in increased expression of VEGFA mRNA]; Losartan promotes the reaction [AGT protein results in increased secretion of VEGFA protein]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of MMP7 protein]]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]]
Losartan results in increased secretion of AGT protein; Losartan results in increased secretion of AGT protein alternative form
[Losartan results in decreased activity of AGT protein] which results in decreased activity of TGFB1 protein; Losartan results in decreased activity of AGT protein
Losartan results in decreased susceptibility to AGT protein modified form
Losartan results in increased expression of AGT protein
Losartan results in decreased activity of AGT protein; Losartan results in decreased activity of AGT protein modified form
Losartan results in decreased expression of AGT protein; Losartan results in decreased expression of AGT protein alternative form; Losartan results in decreased expression of AGT protein modified form
[Lisinopril co-treated with Losartan] results in increased expression of AGT mRNA; [Losartan co-treated with Carvedilol] results in decreased susceptibility to AGT protein modified form; Carvedilol inhibits the reaction [Losartan results in decreased susceptibility to AGT protein modified form]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Losartan inhibits the reaction [[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein]; Losartan inhibits the reaction [AGT protein affects the abundance of Cholesterol]; Losartan inhibits the reaction [AGT protein affects the localization of Calcium]; Losartan inhibits the reaction [AGT protein affects the localization of Lipids]; Losartan inhibits the reaction [AGT protein alternative form results in increased expression of PDGFA mRNA alternative form]; Losartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; Losartan inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]; Losartan inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 mRNA]; Losartan inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 protein]; Losartan inhibits the reaction [AGT protein modified form results in increased phosphorylation of GSK3B protein]; Losartan inhibits the reaction [AGT protein modified form results in increased phosphorylation of MAPT protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of CPT1A mRNA]; Losartan inhibits the reaction [AGT protein results in increased abundance of Fatty Acids, Nonesterified]; Losartan inhibits the reaction [AGT protein results in increased abundance of Glycerol]; Losartan inhibits the reaction [AGT protein results in increased abundance of Norepinephrine]; Losartan inhibits the reaction [AGT protein results in increased abundance of Triglycerides]; Losartan inhibits the reaction [AGT protein results in increased activity of CREB1 protein]; Losartan inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of ATP1A1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of ENG protein]; Losartan inhibits the reaction [AGT protein results in increased expression of FASN mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of FOS protein]; Losartan inhibits the reaction [AGT protein results in increased expression of HMGCR mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of HSPA5 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of MYLK protein]; Losartan inhibits the reaction [AGT protein results in increased expression of PARP1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of PDGFB mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PDGFD mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PDGFRB mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of POSTN mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PPARA mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PPARG mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PPARGC1A mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PTHLH mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PTHLH protein]; Losartan inhibits the reaction [AGT protein results in increased expression of REG3G mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of SREBF1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of TSC22D1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of UCP2 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of UCP3 mRNA]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of EIF2S1 protein]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of SREBF1 protein]; Losartan inhibits the reaction [AGT protein results in increased secretion of COL3A1 protein]; Losartan inhibits the reaction [AGT protein results in increased secretion of PRL protein]; Losartan inhibits the reaction [Carvedilol results in decreased susceptibility to AGT protein modified form]; Losartan inhibits the reaction [Ethanol results in increased secretion of AGT protein alternative form]; Losartan inhibits the reaction [Folic Acid results in increased localization of [AGT protein binds to AGTR1A protein]]; Losartan inhibits the reaction [Folic Acid results in increased localization of AGT protein]; Losartan inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; Losartan inhibits the reaction [Sodium Chloride results in increased expression of AGT protein]; Losartan inhibits the reaction [Tobacco Smoke Pollution results in increased expression of AGT protein]; Losartan promotes the reaction [AGTR2 protein binds to AGT protein]; Losartan promotes the reaction [Isoproterenol results in increased expression of AGT protein]
Losartan inhibits the reaction [AGT protein affects the localization of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in decreased abundance of angiotensin I (1-7)]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of NFE2L2 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of NPHS1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of PODXL protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of WT1 protein]; Losartan inhibits the reaction [AGT protein results in increased activity of PARP1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of ACE protein]; Losartan inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGT protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AKT2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CCL2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of DES protein]; Losartan inhibits the reaction [AGT protein results in increased expression of FOS protein]; Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of RELA protein]; Losartan inhibits the reaction [AGT protein results in increased expression of REN1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of SOD3 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of TWIST1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of VIM protein]; Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 protein]; Losartan inhibits the reaction [Silicon Dioxide results in decreased expression of AGT protein alternative form]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of AGT protein]		 CTD PMID:1387008 PMID:7965263 PMID:8403307 PMID:8952583 PMID:9124547 PMID:9176287 PMID:9519251 PMID:9533614 PMID:10082498 PMID:10400907 PMID:10517737 PMID:11463773 PMID:11709406 PMID:11967826 PMID:12084390 PMID:12411096 PMID:12431451 PMID:12692751 PMID:14630723 PMID:14722030 PMID:15121739 PMID:15213268 PMID:15361886 PMID:15502880 PMID:15528393 PMID:15539634 PMID:15728788 PMID:15741261 PMID:15897343 PMID:16176966 PMID:16221218 PMID:16251426 PMID:16539842 PMID:17043664 PMID:17224469 PMID:17481528 PMID:17666345 PMID:18060435 PMID:18267125 PMID:18511912 PMID:19109942 PMID:19183357 PMID:19298698 PMID:20178811 PMID:20232302 PMID:21047287 PMID:21152098 PMID:21166975 PMID:21613610 PMID:21613793 PMID:22982071 PMID:22982863 PMID:23300732 PMID:23875703 PMID:25398788 PMID:26464165 PMID:27798352 PMID:28578904 PMID:29609002 PMID:31144504 PMID:33007385 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions
decreases expression
increases expression
decreases activity		 ISO
EXP		 [Losartan results in decreased activity of AGTR1 protein] which results in decreased abundance of Aldosterone; [Losartan results in decreased activity of AGTR1 protein] which results in increased expression of AGT protein alternative form; [Losartan results in decreased activity of AGTR1 protein] which results in increased expression of REN protein; Losartan binds to and results in decreased activity of AGTR1 protein; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]
Losartan binds to and results in decreased activity of AGTR1A protein; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; Losartan inhibits the reaction [Hydrogen Peroxide results in increased expression of AGTR1A mRNA]; Losartan inhibits the reaction [Oxygen deficiency results in increased expression of AGTR1 protein]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of AGTR1 protein]
Losartan results in decreased expression of AGTR1 protein; Losartan results in decreased expression of AGTR1A mRNA; Losartan results in decreased expression of AGTR1A protein
Losartan results in increased expression of AGTR1 mRNA; Losartan results in increased expression of AGTR1A mRNA
[Cilazapril co-treated with Losartan] promotes the reaction [Doxorubicin results in increased expression of AGTR1 mRNA]; Losartan binds to and results in decreased activity of AGTR1 protein; Losartan binds to and results in decreased activity of AGTR1A protein; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased expression of AGTR1A mRNA]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased expression of AGTR1A protein]; Losartan inhibits the reaction [Doxorubicin results in increased expression of AGTR1 mRNA]; Losartan inhibits the reaction [Doxorubicin results in increased expression of AGTR1 protein]; Losartan inhibits the reaction [Folic Acid results in increased localization of [AGT protein binds to AGTR1A protein]]		 CTD PMID:9124547 PMID:9533614 PMID:10821809 PMID:11893553 PMID:12930639 PMID:15157388 PMID:15331931 PMID:15528393 PMID:15728788 PMID:15807884 PMID:15809360 PMID:18267125 PMID:18300857 PMID:18765277 PMID:22306536 PMID:25511041 PMID:28091615 PMID:28578904 PMID:33007385 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions
increases expression
decreases expression		 EXP
ISO		 [Losartan co-treated with Cilazapril] inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA]; Losartan inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA]; Losartan promotes the reaction [AGTR2 protein binds to AGT protein]
Losartan inhibits the reaction [Oxygen deficiency results in decreased expression of AGTR2 protein]
Losartan results in increased expression of AGTR2 protein
Losartan results in decreased expression of AGTR2 mRNA		 CTD PMID:9336375 PMID:11967826 PMID:15331931 PMID:18300857 PMID:25511041 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of AKT2 protein] CTD PMID:28578904 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162 		JBrowse link
G Alb albumin affects binding ISO Losartan binds to ALB protein; Losartan binds to ALB protein modified form CTD PMID:27470663 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase decreases expression EXP Losartan results in decreased expression of ALOX15 mRNA; Losartan results in decreased expression of ALOX15 protein CTD PMID:15100363 NCBI chr10:56,953,692...56,962,145
Ensembl chr10:56,953,691...56,962,161 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase decreases expression EXP Losartan results in decreased expression of ALOX5 protein CTD PMID:21377515 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303 		JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor decreases expression
multiple interactions		 ISO Losartan results in decreased expression of AMBP protein
benazepril promotes the reaction [Losartan results in decreased expression of AMBP protein]; Losartan promotes the reaction [benazepril results in decreased expression of AMBP protein]		 CTD PMID:16303729 NCBI chr 5:78,975,690...78,986,021
Ensembl chr 5:78,975,678...78,985,990 		JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of ATP1A1 mRNA] CTD PMID:14630723 NCBI chr 2:204,003,742...204,032,023
Ensembl chr 2:204,003,742...204,032,023 		JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 increases expression EXP Losartan results in increased expression of ATP1A2 mRNA; Losartan results in increased expression of ATP1A2 protein CTD PMID:18418421 NCBI chr13:90,651,682...90,676,629
Ensembl chr13:90,651,686...90,676,629 		JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 decreases expression EXP Losartan results in decreased expression of ATP1A3 mRNA; Losartan results in decreased expression of ATP1A3 protein CTD PMID:18418421 NCBI chr 1:81,852,423...81,881,565
Ensembl chr 1:81,852,429...81,881,549 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions EXP Losartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAK1 mRNA] CTD PMID:15502641 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
decreases expression		 EXP Losartan inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]; Losartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAX mRNA]
Losartan results in increased expression of BAX protein
Losartan results in decreased expression of BAX mRNA		 CTD PMID:12623880 PMID:12845756 PMID:15502641 PMID:17784886 PMID:19298698 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
affects expression
increases expression
decreases expression		 EXP Losartan promotes the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of BCL2 mRNA]
Losartan affects the expression of BCL2 protein
Losartan results in increased expression of BCL2 protein
Losartan results in decreased expression of BCL2 protein		 CTD PMID:12623880 PMID:15502641 PMID:19298698 PMID:21153712 PMID:22000973 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions EXP Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 mRNA]; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 protein] CTD PMID:27412937 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions ISO [KN 93 co-treated with Losartan] inhibits the reaction [bisphenol A results in increased phosphorylation of CAMK2A protein]; Losartan inhibits the reaction [bisphenol A results in increased phosphorylation of CAMK2A protein] CTD PMID:25103225 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869 		JBrowse link
G Casp3 caspase 3 increases cleavage
decreases activity
multiple interactions		 EXP Losartan results in increased cleavage of CASP3 protein
Losartan results in decreased activity of CASP3 protein
Losartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]		 CTD PMID:12623880 PMID:23300732 PMID:23875703 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 decreases activity EXP Losartan results in decreased activity of CASP8 protein CTD PMID:23875703 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 increases cleavage EXP Losartan results in increased cleavage of CASP9 protein CTD PMID:12623880 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Cat catalase decreases expression
multiple interactions		 EXP Losartan results in decreased expression of CAT protein
Losartan inhibits the reaction [Streptozocin results in decreased activity of CAT protein]		 CTD PMID:23875703 PMID:30958922 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression		 EXP
ISO		 Losartan inhibits the reaction [Estrogens deficiency results in increased expression of CCL2 protein]; Losartan inhibits the reaction [Ethylene Glycol results in increased expression of CCL2 protein]
Losartan inhibits the reaction [AGT protein results in increased expression of CCL2 protein]
Losartan results in decreased expression of CCL2 mRNA; Losartan results in decreased expression of CCL2 protein		 CTD PMID:10925121 PMID:16284884 PMID:17922026 PMID:19553526 PMID:28578904 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions EXP Losartan inhibits the reaction [Estrogens deficiency results in increased expression of CCL3 protein] CTD PMID:19553526 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions EXP Losartan inhibits the reaction [Ethylene Glycol results in increased expression of CCL5 protein] CTD PMID:16284884 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA] CTD PMID:29859236 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 decreases expression EXP Losartan results in decreased expression of CCR2 mRNA CTD PMID:17922026
G Cd36 CD36 molecule increases expression
decreases expression
multiple interactions		 ISO Losartan results in increased expression of CD36 mRNA
Losartan results in decreased expression of CD36 mRNA
Losartan promotes the reaction [[Dietary Fats co-treated with Cholesterol] results in increased expression of CD36 mRNA]
T 0070907 inhibits the reaction [Losartan results in increased expression of CD36 mRNA]		 CTD PMID:18302760 PMID:22124178 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749 		JBrowse link
G Cd74 CD74 molecule decreases expression EXP Losartan results in decreased expression of CD74 mRNA CTD PMID:15100363 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO Losartan inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]
Losartan inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; Losartan inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]		 CTD PMID:28578904 PMID:33007385 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Losartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN1A protein] CTD PMID:33380422 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions ISO Losartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN2A protein] CTD PMID:33380422 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression
multiple interactions		 EXP
ISO		 Losartan results in decreased expression of COL1A1 mRNA
Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of COL1A1 mRNA]		 CTD PMID:15100363 PMID:18300870 PMID:23585870 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789 		JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression
multiple interactions		 EXP
ISO		 Losartan results in decreased expression of COL3A1 mRNA
Losartan inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]
Losartan inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of COL3A1 mRNA]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of COL3A1 protein]
Losartan inhibits the reaction [AGT protein results in increased secretion of COL3A1 protein]; Losartan inhibits the reaction [Paraquat results in increased expression of COL3A1 protein]		 CTD PMID:15100363 PMID:16539842 PMID:23585870 PMID:25233898 PMID:28578904 PMID:33007385 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217 		JBrowse link
G Col4a1 collagen type IV alpha 1 chain decreases expression EXP Losartan results in decreased expression of COL4A1 mRNA CTD PMID:16191423 NCBI chr16:83,522,162...83,632,153
Ensembl chr16:83,522,162...83,632,153 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions EXP Losartan inhibits the reaction [AGT protein results in decreased expression of CPT1A mRNA] CTD PMID:19109942 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased activity of CREB1 protein]; Losartan inhibits the reaction [Folic Acid results in increased activity of CREB1 protein] CTD PMID:15728788 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO Losartan inhibits the reaction [AGT protein affects the localization of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 protein]
Losartan inhibits the reaction [AGT protein affects the localization of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of and results in increased activity of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 mRNA]		 CTD PMID:28578904 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Cubn cubilin multiple interactions EXP Losartan inhibits the reaction [Cadmium results in decreased expression of CUBN protein] CTD PMID:24093454 NCBI chr17:80,584,921...80,807,181
Ensembl chr17:80,584,878...80,807,243 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP Losartan inhibits the reaction [Estrogens deficiency results in increased expression of CXCL1 protein] CTD PMID:19553526 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457 		JBrowse link
G Cycs cytochrome c, somatic increases expression EXP Losartan results in increased expression of CYCS protein CTD PMID:18971572 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Losartan results in increased expression of CYP1A1 mRNA CTD PMID:9860486 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases hydroxylation
increases metabolic processing
affects metabolic processing
multiple interactions		 ISO CYP2C9 protein results in increased hydroxylation of Losartan
CYP2C9 protein results in increased metabolism of Losartan
CYP2C9 protein affects the metabolism of Losartan
CYP2C9 gene mutant form inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Losartan]; Resveratrol inhibits the reaction [CYP2C9 protein results in increased metabolism of Losartan]		 CTD PMID:19082874 PMID:19715737 PMID:20405111 PMID:20716633 PMID:21321060 PMID:25994031 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434 		JBrowse link
G Dcn decorin decreases expression EXP Losartan results in decreased expression of DCN mRNA CTD PMID:15100363 NCBI chr 7:38,742,250...38,782,282
Ensembl chr 7:38,742,051...38,782,323 		JBrowse link
G Des desmin multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of DES protein] CTD PMID:28578904 NCBI chr 9:82,556,574...82,564,288
Ensembl chr 9:82,556,573...82,564,294 		JBrowse link
G Edn1 endothelin 1 decreases expression
multiple interactions		 ISO
EXP		 Losartan results in decreased expression of EDN1 protein
Losartan results in decreased expression of EDN1 mRNA; Losartan results in decreased expression of EDN1 protein
Losartan inhibits the reaction [Nitroglycerin results in increased expression of EDN1 protein]
Losartan inhibits the reaction [AGT protein modified form results in increased expression of EDN1 protein]		 CTD PMID:11369837 PMID:12901495 PMID:16191423 PMID:17666345 PMID:18971572 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324 		JBrowse link
G Ednra endothelin receptor type A multiple interactions
decreases expression		 EXP Atorvastatin promotes the reaction [Losartan results in decreased expression of EDNRA mRNA]; Losartan promotes the reaction [Atorvastatin results in decreased expression of EDNRA mRNA] CTD PMID:23091284 NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased phosphorylation of EIF2S1 protein] CTD PMID:25398788 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041 		JBrowse link
G Eln elastin decreases expression EXP Losartan results in decreased expression of ELN mRNA CTD PMID:15100363 NCBI chr12:24,978,478...25,021,864
Ensembl chr12:24,978,483...25,021,863 		JBrowse link
G Eng endoglin multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of ENG protein] CTD PMID:15539634 NCBI chr 3:11,679,530...11,717,486
Ensembl chr 3:11,679,530...11,717,485 		JBrowse link
G F3 coagulation factor III, tissue factor decreases expression
multiple interactions		 ISO Losartan results in decreased expression of F3 mRNA; Losartan results in decreased expression of F3 protein
Losartan inhibits the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]; Losartan inhibits the reaction [AGT protein modified form promotes the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]]		 CTD PMID:18060435 PMID:22188725 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272 		JBrowse link
G Faslg Fas ligand decreases expression EXP Losartan results in decreased expression of FASLG mRNA CTD PMID:10925121 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705 		JBrowse link
G Fasn fatty acid synthase multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of FASN mRNA] CTD PMID:19109942 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 decreases expression ISO Losartan results in decreased expression of FLT1 mRNA; Losartan results in decreased expression of FLT1 protein CTD PMID:19771429 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905 		JBrowse link
G Flt4 Fms related receptor tyrosine kinase 4 decreases expression ISO Losartan results in decreased expression of FLT4 mRNA CTD PMID:19771429 NCBI chr10:35,078,782...35,120,296
Ensembl chr10:35,078,726...35,121,599 		JBrowse link
G Fn1 fibronectin 1 decreases expression EXP Losartan results in decreased expression of FN1 mRNA; Losartan results in decreased expression of FN1 protein CTD PMID:16191423 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO
EXP		 Losartan inhibits the reaction [AGT protein results in increased expression of FOS protein]; Losartan inhibits the reaction [Furosemide results in increased expression of FOS protein]; Losartan inhibits the reaction [Polyethylene Glycols results in increased expression of FOS protein] CTD PMID:11463773 PMID:15528393 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression EXP Losartan results in increased expression of GJA1 protein CTD PMID:18971572 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO		 Losartan inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]
Losartan inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]		 CTD PMID:15573910 PMID:29859236 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP Losartan inhibits the reaction [AGT protein modified form results in increased phosphorylation of GSK3B protein] CTD PMID:22982863 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP Losartan inhibits the reaction [Cadmium results in increased expression of HAVCR1] CTD PMID:24093454 NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of HMGCR mRNA] CTD PMID:19109942 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Hmox1 heme oxygenase 1 increases activity
multiple interactions
increases expression		 EXP
ISO		 Losartan results in increased activity of HMOX1 protein
Losartan inhibits the reaction [AGT protein results in decreased expression of HMOX1 protein]
Losartan results in increased expression of HMOX1 mRNA
cobaltiprotoporphyrin promotes the reaction [Losartan results in increased activity of HMOX1 protein]; cobaltiprotoporphyrin promotes the reaction [Losartan results in increased expression of HMOX1 mRNA]		 CTD PMID:19804535 PMID:28578904 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of HSPA5 protein] CTD PMID:25398788 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases secretion		 ISO Losartan inhibits the reaction [AGT protein results in increased secretion of ICAM1 protein]
Losartan results in decreased secretion of ICAM1 protein		 CTD PMID:10517737 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Ifng interferon gamma increases expression EXP Losartan results in increased expression of IFNG protein CTD PMID:23875703 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Il10 interleukin 10 increases expression EXP Losartan results in increased expression of IL10 mRNA CTD PMID:18971572 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions
decreases expression		 ISO
EXP		 Losartan inhibits the reaction [IL1A protein results in increased expression of VEGFA mRNA]; Losartan inhibits the reaction [IL1A protein results in increased expression of VEGFA protein]
Losartan results in decreased expression of IL1A protein		 CTD PMID:17299153 PMID:23875703 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086 		JBrowse link
G Il6 interleukin 6 decreases expression
increases expression
multiple interactions		 ISO
EXP		 Losartan results in decreased expression of IL6 mRNA
Losartan results in increased expression of IL6 protein
Losartan inhibits the reaction [bisphenol A results in increased expression of IL6 mRNA]; Losartan inhibits the reaction [Ethylene Glycol results in increased expression of IL6 protein]		 CTD PMID:16284884 PMID:21479465 PMID:23875703 PMID:30677511 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Itga3 integrin subunit alpha 3 decreases expression EXP Losartan results in decreased expression of ITGA3 protein CTD PMID:15100363 NCBI chr10:82,855,841...82,887,755
Ensembl chr10:82,855,613...82,887,497 		JBrowse link
G Itga6 integrin subunit alpha 6 decreases expression EXP Losartan results in decreased expression of ITGA6 protein CTD PMID:15100363 NCBI chr 3:58,442,904...58,515,124
Ensembl chr 3:58,443,101...58,515,124 		JBrowse link
G Kdr kinase insert domain receptor multiple interactions EXP Losartan inhibits the reaction [Cyclosporine results in increased expression of KDR mRNA] CTD PMID:12110003 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183 		JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions ISO Losartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN1A protein]; Losartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN2A protein] CTD PMID:33380422 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558 		JBrowse link
G Lox lysyl oxidase decreases expression EXP Losartan results in decreased expression of LOX mRNA CTD PMID:15100363 NCBI chr18:47,500,320...47,577,819
Ensembl chr18:47,500,330...47,577,819 		JBrowse link
G Lum lumican decreases expression EXP Losartan results in decreased expression of LUM mRNA CTD PMID:15100363 NCBI chr 7:38,820,058...38,826,862
Ensembl chr 7:38,819,771...38,826,862 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
increases activity		 EXP
ISO		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Losartan results in increased phosphorylation of MAPK1 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]
Losartan results in increased activity of MAPK1 protein
Losartan inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein]		 CTD PMID:11711055 PMID:16079071 PMID:18267125 PMID:18511912 PMID:20056918 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 decreases expression EXP Losartan results in decreased expression of MAPK14 protein CTD PMID:28091615 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
increases activity		 ISO
EXP		 Losartan inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK3 protein]
Losartan results in increased phosphorylation of MAPK3 protein
Losartan results in increased activity of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Losartan results in increased phosphorylation of MAPK3 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]		 CTD PMID:11711055 PMID:16079071 PMID:18267125 PMID:18511912 PMID:20056918 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP Losartan inhibits the reaction [AGT protein modified form results in increased phosphorylation of MAPT protein] CTD PMID:22982863 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517 		JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor multiple interactions ISO Losartan inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; Losartan inhibits the reaction [Silicon Dioxide results in decreased expression of MAS1 protein] CTD PMID:33007385 NCBI chr 1:48,076,761...48,108,218
Ensembl chr 1:48,077,033...48,108,216 		JBrowse link
G Mgp matrix Gla protein decreases expression EXP Losartan results in decreased expression of MGP mRNA CTD PMID:15100363 NCBI chr 4:170,856,783...170,860,105
Ensembl chr 4:170,856,751...170,860,225 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP
ISO		 Losartan inhibits the reaction [[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased activity of MMP2 protein]
Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of MMP2 protein]; Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 mRNA]		 CTD PMID:12930639 PMID:16251426 PMID:23585870 PMID:29859236 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Mmp23 matrix metallopeptidase 23 decreases expression EXP Losartan results in decreased expression of MMP23 mRNA CTD PMID:15100363 NCBI chr 5:173,078,811...173,082,834
Ensembl chr 5:173,078,590...173,081,839 		JBrowse link
G Mmp7 matrix metallopeptidase 7 multiple interactions ISO ICG 001 promotes the reaction [Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]]; Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of MMP7 protein]] CTD PMID:28578904 NCBI chr 8:5,893,253...5,900,965
Ensembl chr 8:5,893,249...5,901,049 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions		 EXP
ISO		 Losartan results in decreased expression of MMP9 mRNA
Losartan inhibits the reaction [Paraquat results in increased expression of MMP9 mRNA]
Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]		 CTD PMID:18971572 PMID:23585870 PMID:25233898 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor affects expression EXP Losartan affects the expression of MYC protein CTD PMID:22000973 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240 		JBrowse link
G Myh11 myosin heavy chain 11 decreases expression EXP Losartan results in decreased expression of MYH11 mRNA CTD PMID:15100363 NCBI chr10:764,421...859,184
Ensembl chr10:764,421...859,184 		JBrowse link
G Myh6 myosin heavy chain 6 multiple interactions EXP Losartan inhibits the reaction [Streptozocin results in decreased expression of MYH6 mRNA]; Losartan inhibits the reaction [Streptozocin results in decreased expression of MYH6 protein] CTD PMID:15362513 NCBI chr15:33,605,653...33,629,730
Ensembl chr15:33,605,654...33,629,699 		JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions EXP Losartan inhibits the reaction [Streptozocin results in increased expression of MYH7 mRNA]; Losartan inhibits the reaction [Streptozocin results in increased expression of MYH7 protein] CTD PMID:15362513 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089 		JBrowse link
G Mylk myosin light chain kinase multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of MYLK protein] CTD PMID:18511912 NCBI chr11:69,013,060...69,260,039
Ensembl chr11:69,013,050...69,223,158 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO
EXP		 Losartan inhibits the reaction [Hydrogen Peroxide results in increased expression of NCF1 mRNA]
Losartan inhibits the reaction [Ethanol affects the localization of NCF1 protein]		 CTD PMID:22306536 PMID:22497828 PMID:22982071 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300 		JBrowse link
G Ndst1 N-deacetylase and N-sulfotransferase 1 multiple interactions EXP Losartan inhibits the reaction [Streptozocin results in decreased expression of NDST1 protein] CTD PMID:15793251 NCBI chr18:55,951,497...56,014,107
Ensembl chr18:55,955,389...55,992,885 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases expression
multiple interactions		 EXP
ISO		 Losartan results in decreased expression of NFE2L2 mRNA
Losartan inhibits the reaction [AGT protein results in decreased expression of NFE2L2 protein]		 CTD PMID:18765277 PMID:28578904 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP
ISO		 Losartan inhibits the reaction [Ethylene Glycol results in increased expression of NFKB1 protein]
Losartan inhibits the reaction [Diethylnitrosamine results in decreased expression of NFKB1 protein]		 CTD PMID:16284884 PMID:29859236 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Nos1 nitric oxide synthase 1 increases phosphorylation
multiple interactions		 EXP Losartan results in increased phosphorylation of NOS1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Losartan results in increased phosphorylation of NOS1 protein]		 CTD PMID:20056918 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341 		JBrowse link
G Nos2 nitric oxide synthase 2 affects expression
decreases expression
increases expression		 EXP Losartan affects the expression of NOS2 mRNA
Losartan results in decreased expression of NOS2 mRNA; Losartan results in decreased expression of NOS2 protein
Losartan results in increased expression of NOS2 protein		 CTD PMID:12198324 PMID:16191423 PMID:18390819 PMID:21377515 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nos3 nitric oxide synthase 3 affects expression
increases expression
multiple interactions
increases phosphorylation		 EXP Losartan affects the expression of NOS3 mRNA
Losartan results in increased expression of NOS3 mRNA
[Losartan co-treated with Atorvastatin] results in increased expression of NOS3 mRNA; Losartan inhibits the reaction [Sodium Chloride results in decreased expression of NOS3 protein]
Losartan results in increased phosphorylation of NOS3 protein		 CTD PMID:12198324 PMID:18390819 PMID:18971572 PMID:20232302 PMID:23091284 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions ISO [Losartan co-treated with ICG 001] inhibits the reaction [AGT protein results in decreased expression of NPHS2 protein] CTD PMID:28578904 NCBI chr13:73,929,136...73,941,522
Ensembl chr13:73,929,136...73,941,522 		JBrowse link
G Nppa natriuretic peptide A multiple interactions
decreases expression		 EXP Losartan inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPA mRNA]
Losartan results in decreased expression of NPPA protein		 CTD PMID:12198334 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705 		JBrowse link
G Nppb natriuretic peptide B multiple interactions
decreases expression		 EXP [Atenolol co-treated with Losartan co-treated with Doxazosin] results in decreased expression of NPPB mRNA; [Losartan co-treated with Doxazosin] results in decreased expression of NPPB mRNA; [Losartan co-treated with Nifedipine] results in decreased expression of NPPB mRNA; Losartan inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPB mRNA]
Losartan results in decreased expression of NPPB mRNA; Losartan results in decreased expression of NPPB protein		 CTD PMID:12198334 PMID:15969258 PMID:17666919 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531 		JBrowse link
G Npr1 natriuretic peptide receptor 1 affects response to substance ISO NPR1 protein mutant form affects the susceptibility to Losartan CTD PMID:20881240 NCBI chr 2:189,840,403...189,857,032
Ensembl chr 2:189,840,403...189,856,090 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression EXP Losartan results in increased expression of NR1H3 protein CTD PMID:28091615 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750 		JBrowse link
G Nrf1 nuclear respiratory factor 1 increases expression EXP Losartan results in increased expression of NRF1 mRNA CTD PMID:18765277 NCBI chr 4:57,335,732...57,445,317
Ensembl chr 4:57,378,069...57,445,341 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP
ISO		 Losartan inhibits the reaction [AGT protein results in increased expression of PARP1 protein]
Losartan inhibits the reaction [AGT protein results in increased activity of PARP1 protein]		 CTD PMID:15502880 PMID:21613793 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pdgfa platelet derived growth factor subunit A multiple interactions EXP Losartan inhibits the reaction [AGT protein alternative form results in increased expression of PDGFA mRNA alternative form] CTD PMID:12431451 NCBI chr12:17,734,141...17,756,186
Ensembl chr12:17,734,133...17,755,285 		JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of PDGFB mRNA]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein] CTD PMID:12930639 PMID:17043664 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741 		JBrowse link
G Pdgfd platelet derived growth factor D multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of PDGFD mRNA] CTD PMID:17043664 NCBI chr 8:4,441,010...4,666,754
Ensembl chr 8:4,440,876...4,669,014 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of PDGFRB mRNA] CTD PMID:17043664 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381 		JBrowse link
G Pdlim3 PDZ and LIM domain 3 decreases expression EXP Losartan results in decreased expression of PDLIM3 mRNA CTD PMID:15100363 NCBI chr16:49,543,140...49,574,362
Ensembl chr16:49,543,142...49,574,390 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 decreases expression ISO Losartan results in decreased expression of PECAM1 mRNA CTD PMID:19771429 NCBI chr10:94,850,971...94,913,202 JBrowse link
G Plat plasminogen activator, tissue type decreases expression EXP Losartan results in decreased expression of PLAT mRNA CTD PMID:15100363 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889 		JBrowse link
G Podxl podocalyxin-like multiple interactions ISO Losartan inhibits the reaction [AGT protein results in decreased expression of PODXL protein] CTD PMID:28578904 NCBI chr 4:58,829,049...58,893,353
Ensembl chr 4:58,829,060...58,893,170 		JBrowse link
G Postn periostin multiple interactions
decreases expression		 EXP
ISO		 Losartan inhibits the reaction [AGT protein results in increased expression of POSTN mRNA]
Losartan results in decreased expression of POSTN mRNA		 CTD PMID:15121739 PMID:21641384 NCBI chr 2:143,656,820...143,688,087
Ensembl chr 2:143,656,793...143,688,087 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of PPARA mRNA] CTD PMID:19109942 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP
ISO		 Losartan inhibits the reaction [AGT protein results in increased expression of PPARG mRNA]
Losartan inhibits the reaction [[Dietary Fats co-treated with Cholesterol] results in increased expression of PPARG mRNA]		 CTD PMID:18302760 PMID:19109942 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions
increases expression		 EXP Losartan inhibits the reaction [AGT protein results in increased expression of PPARGC1A mRNA]
Losartan results in increased expression of PPARGC1A mRNA		 CTD PMID:18765277 PMID:18971572 PMID:19109942 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009 		JBrowse link
G Prkcb protein kinase C, beta multiple interactions EXP Losartan inhibits the reaction [Ethanol results in increased expression of PRKCB protein] CTD PMID:22497828 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831 		JBrowse link
G Prl prolactin multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased secretion of PRL protein] CTD PMID:14722030 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression		 EXP
ISO		 Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [Phenylephrine results in increased expression of PTGS2 mRNA]; Losartan inhibits the reaction [Phenylephrine results in increased expression of PTGS2 protein]
Losartan inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]
Losartan results in decreased expression of PTGS2 mRNA; Losartan results in decreased expression of PTGS2 protein		 CTD PMID:17244722 PMID:18267125 PMID:21377515 PMID:28578904 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Pth1r parathyroid hormone 1 receptor multiple interactions EXP Losartan inhibits the reaction [Folic Acid results in decreased expression of PTH1R protein]; Losartan inhibits the reaction [Gentamicins results in decreased expression of PTH1R protein] CTD PMID:15728788 NCBI chr 8:118,984,531...119,012,803
Ensembl chr 8:118,988,053...119,012,671 		JBrowse link
G Pthlh parathyroid hormone-like hormone multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of PTHLH mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PTHLH protein]; Losartan inhibits the reaction [Folic Acid results in increased expression of PTHLH mRNA]; Losartan inhibits the reaction [Folic Acid results in increased expression of PTHLH protein]; Losartan inhibits the reaction [Gentamicins results in increased expression of PTHLH protein] CTD PMID:15728788 NCBI chr 4:181,663,425...181,674,181 JBrowse link
G Reg3g regenerating family member 3 gamma multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of REG3G mRNA] CTD PMID:27798352 NCBI chr 4:109,529,679...109,532,234
Ensembl chr 4:109,529,679...109,532,234 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO		 Losartan inhibits the reaction [Doxorubicin results in increased expression of RELA mRNA]
Losartan inhibits the reaction [AGT protein results in increased expression of RELA protein]; Losartan inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of RELA protein]		 CTD PMID:15157388 PMID:28578904 PMID:29859236 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Ren renin multiple interactions
increases expression
increases activity		 ISO
EXP		 [Losartan results in decreased activity of AGTR1 protein] which results in increased expression of REN protein; Losartan inhibits the reaction [AGT protein results in increased expression of REN protein]; Losartan promotes the reaction [Hydrochlorothiazide results in increased expression of REN protein]
Losartan inhibits the reaction [AGT protein results in increased expression of REN1 protein]
Losartan results in increased expression of REN mRNA; Losartan results in increased expression of REN protein
Losartan results in increased activity of REN protein
[Lisinopril co-treated with Losartan] results in increased expression of REN mRNA; Losartan inhibits the reaction [Ethanol results in increased activity of REN protein]; Losartan promotes the reaction [Isoproterenol results in increased expression of REN protein]		 CTD PMID:1387008 PMID:7965263 PMID:8382237 PMID:8403307 PMID:9124547 PMID:9245700 PMID:9431853 PMID:9533614 PMID:11709406 PMID:12013499 PMID:12569265 PMID:16221218 PMID:22982071 PMID:28578904 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151 		JBrowse link
G RT1-Da RT1 class II, locus Da decreases expression EXP Losartan results in decreased expression of RT1-DA mRNA CTD PMID:15100363 NCBI chr20:4,127,644...4,132,616
Ensembl chr20:4,127,644...4,132,616 		JBrowse link
G RT1-S3 RT1 class Ib, locus S3 decreases expression EXP Losartan results in decreased expression of RT1-S3 mRNA CTD PMID:15100363 NCBI chr20:3,176,124...3,180,825
Ensembl chr20:3,176,107...3,179,818 		JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions EXP Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 mRNA]; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 protein] CTD PMID:27412937 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092 		JBrowse link
G S100a4 S100 calcium-binding protein A4 multiple interactions ISO [Losartan co-treated with ICG 001] inhibits the reaction [AGT protein results in increased expression of S100A4 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of S100A4 protein] CTD PMID:28578904 NCBI chr 2:189,997,278...189,999,587
Ensembl chr 2:189,997,129...189,999,604 		JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 multiple interactions EXP Losartan inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 mRNA]; Losartan inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 protein] CTD PMID:29609002 NCBI chr 2:218,654,406...218,658,761
Ensembl chr 2:218,654,554...218,658,761 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions ISO Losartan inhibits the reaction [[Dietary Fats co-treated with Cholesterol] results in decreased expression of SCARB1 mRNA] CTD PMID:18302760 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455 		JBrowse link
G Sdc2 syndecan 2 decreases expression EXP Losartan results in decreased expression of SDC2 mRNA; Losartan results in decreased expression of SDC2 protein CTD PMID:15100363 NCBI chr 7:71,572,731...71,686,139
Ensembl chr 7:71,572,941...71,686,044 		JBrowse link
G Selp selectin P multiple interactions EXP Losartan inhibits the reaction [Estrogens deficiency results in increased expression of SELP protein] CTD PMID:19553526 NCBI chr13:82,428,914...82,464,629
Ensembl chr13:82,429,063...82,464,628 		JBrowse link
G Sfrp2 secreted frizzled-related protein 2 decreases response to substance EXP SFRP2 protein results in decreased susceptibility to Losartan CTD PMID:23875703 NCBI chr 2:182,723,732...182,731,277
Ensembl chr 2:182,723,854...182,731,764 		JBrowse link
G Slc22a12 solute carrier family 22 member 12 decreases activity
affects response to substance
decreases expression
multiple interactions		 ISO Losartan results in decreased activity of SLC22A12 protein
SLC22A12 protein affects the susceptibility to Losartan
Losartan results in decreased expression of SLC22A12 mRNA
[Losartan results in decreased activity of SLC22A12 protein] which results in decreased abundance of Uric Acid		 CTD PMID:18670416 PMID:20486468 NCBI chr 1:221,910,787...221,919,277
Ensembl chr 1:221,910,767...221,919,301 		JBrowse link
G Slc22a25 solute carrier family 22, member 25 multiple interactions ISO Losartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate] CTD PMID:17132213 NCBI chr 1:224,596,886...224,698,512
Ensembl chr 1:224,596,887...224,698,514 		JBrowse link
G Slc2a9 solute carrier family 2 member 9 multiple interactions ISO Losartan inhibits the reaction [SLC2A9 protein results in increased uptake of Uric Acid] CTD PMID:19587147 NCBI chr14:77,067,537...77,192,702
Ensembl chr14:77,067,503...77,192,702 		JBrowse link
G Slc9a3 solute carrier family 9 member A3 multiple interactions ISO Losartan inhibits the reaction [Ammonium Chloride results in increased expression of NHE3 protein] CTD PMID:18287403 NCBI chr 1:31,731,652...31,777,144
Ensembl chr 1:31,734,327...31,777,070 		JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO ICG 001 promotes the reaction [Losartan inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]]; Losartan inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]] CTD PMID:28578904 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378 		JBrowse link
G Sod2 superoxide dismutase 2 decreases activity EXP Losartan results in decreased activity of SOD2 protein CTD PMID:18765277 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of SOD3 protein] CTD PMID:10400907 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324 		JBrowse link
G Sparc secreted protein acidic and cysteine rich decreases expression EXP Losartan results in decreased expression of SPARC mRNA CTD PMID:15100363 NCBI chr10:40,742,390...40,764,232
Ensembl chr10:40,742,400...40,764,185 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of SREBF1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of SREBF1 protein] CTD PMID:19109942 PMID:25398788 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO Losartan results in decreased phosphorylation of STAT3 protein CTD PMID:33380422 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases secretion
multiple interactions
decreases activity
decreases expression
increases expression		 ISO
EXP		 Losartan results in decreased secretion of TGFB1 protein
Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of TGFB1 protein]
[Losartan results in decreased activity of AGT protein] which results in decreased activity of TGFB1 protein
Losartan results in decreased expression of TGFB1 mRNA; Losartan results in decreased expression of TGFB1 protein
Losartan results in increased expression of TGFB1 protein
[Losartan co-treated with Cilazapril] inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; [Losartan co-treated with Nifedipine] results in decreased expression of TGFB1 mRNA; Losartan inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased secretion of TGFB1 protein]; Losartan inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; Losartan inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]		 CTD PMID:11369837 PMID:12930639 PMID:12937228 PMID:15331931 PMID:15573910 PMID:16191423 PMID:17330452 PMID:17666919 PMID:17784886 PMID:21152098 PMID:25233898 PMID:29859236 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions
decreases expression		 EXP Losartan inhibits the reaction [Paraquat results in increased expression of TIMP1 mRNA]; Losartan inhibits the reaction [Simvastatin results in decreased expression of TIMP1 mRNA]; Simvastatin inhibits the reaction [Losartan results in decreased expression of TIMP1 mRNA] CTD PMID:20137537 PMID:25233898 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 decreases expression
multiple interactions		 EXP Losartan results in decreased expression of TIMP2 mRNA
Losartan inhibits the reaction [Simvastatin results in decreased expression of TIMP2 mRNA]; Simvastatin inhibits the reaction [Losartan results in decreased expression of TIMP2 mRNA]		 CTD PMID:20137537 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072 		JBrowse link
G Tjp1 tight junction protein 1 decreases expression EXP Losartan results in decreased expression of TJP1 protein CTD PMID:18400868 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469 		JBrowse link
G Tnc tenascin C decreases expression EXP Losartan results in decreased expression of TNC mRNA CTD PMID:15100363 NCBI chr 5:79,789,686...79,874,555
Ensembl chr 5:79,789,671...79,874,671 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 ISO
EXP		 Losartan affects the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Losartan inhibits the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]; Losartan inhibits the reaction [AGT protein modified form promotes the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]]; Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Losartan inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Losartan inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; T 0070907 inhibits the reaction [Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]
Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of TNF protein]
Losartan results in decreased expression of TNF protein
Losartan inhibits the reaction [bisphenol A results in increased expression of TNF mRNA]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased secretion of TNF protein]		 CTD PMID:15573910 PMID:17299153 PMID:18060435 PMID:22124178 PMID:23875703 PMID:29859236 PMID:30677511 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tomm20 translocase of outer mitochondrial membrane 20 decreases expression EXP Losartan results in decreased expression of TOMM20 mRNA CTD PMID:18765277 NCBI chr19:59,863,421...59,873,411
Ensembl chr19:59,863,421...59,873,411 		JBrowse link
G Tp53 tumor protein p53 affects expression EXP Losartan affects the expression of TP53 protein CTD PMID:22000973 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Tsc22d1 TSC22 domain family, member 1 multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of TSC22D1 mRNA] CTD PMID:26464165 NCBI chr15:58,554,358...58,658,156
Ensembl chr15:58,554,374...58,658,153 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of TWIST1 protein] CTD PMID:28578904 NCBI chr 6:53,401,241...53,403,235
Ensembl chr 6:53,401,109...53,403,214 		JBrowse link
G Ucp2 uncoupling protein 2 decreases expression
multiple interactions		 ISO
EXP		 Losartan results in decreased expression of UCP2 mRNA; Losartan results in decreased expression of UCP2 protein
Losartan inhibits the reaction [AGT protein results in increased expression of UCP2 mRNA]		 CTD PMID:17508912 PMID:19109942 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744 		JBrowse link
G Ucp3 uncoupling protein 3 multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of UCP3 mRNA] CTD PMID:19109942 NCBI chr 1:165,482,912...165,495,895
Ensembl chr 1:165,482,155...165,496,206 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP Losartan inhibits the reaction [Estrogens deficiency results in increased expression of VCAM1 protein] CTD PMID:19553526 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression		 ISO
EXP		 Losartan inhibits the reaction [IL1A protein results in increased expression of VEGFA mRNA]; Losartan inhibits the reaction [IL1A protein results in increased expression of VEGFA protein]; Losartan inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Losartan inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; Losartan promotes the reaction [AGT protein results in increased expression of VEGFA mRNA]; Losartan promotes the reaction [AGT protein results in increased secretion of VEGFA protein]
Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of VEGFA protein]; Losartan inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]
Losartan inhibits the reaction [Cyclosporine results in increased expression of VEGFA protein]
Losartan results in decreased expression of VEGFA mRNA; Losartan results in decreased expression of VEGFA protein		 CTD PMID:12110003 PMID:17299153 PMID:17481528 PMID:22188725 PMID:25511041 PMID:29859236 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
G Vegfc vascular endothelial growth factor C decreases expression ISO Losartan results in decreased expression of VEGFC mRNA CTD PMID:19771429 NCBI chr16:40,440,371...40,555,178
Ensembl chr16:40,440,207...40,555,576 		JBrowse link
G Vim vimentin multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of VIM protein]
Losartan inhibits the reaction [AGT protein results in increased expression of VIM protein]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein]		 CTD PMID:28578904 PMID:33007385 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212 		JBrowse link
G Wnt1 Wnt family member 1 multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 protein] CTD PMID:28578904 NCBI chr 7:140,464,999...140,469,046
Ensembl chr 7:140,464,999...140,469,046 		JBrowse link
G Wt1 WT1 transcription factor multiple interactions ISO Losartan inhibits the reaction [AGT protein results in decreased expression of WT1 protein] CTD PMID:28578904 NCBI chr 3:95,133,221...95,180,574
Ensembl chr 3:95,133,713...95,180,564 		JBrowse link
losartan carboxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a25 solute carrier family 22, member 25 multiple interactions ISO losartan carboxylic acid inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate] CTD PMID:17132213 NCBI chr 1:224,596,886...224,698,512
Ensembl chr 1:224,596,887...224,698,514 		JBrowse link
macitentan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression ISO macitentan results in decreased expression of ABCB1 mRNA CTD PMID:28369585 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression ISO macitentan results in decreased expression of ABCC2 mRNA CTD PMID:28369585 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 decreases expression ISO macitentan results in decreased expression of ABCC3 mRNA CTD PMID:28369585 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression ISO macitentan results in decreased expression of SLC10A1 mRNA CTD PMID:28369585 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355 		JBrowse link
PD123319 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin I converting enzyme 2 multiple interactions EXP PD 123319 inhibits the reaction [diminazene aceturate results in increased expression of ACE2 protein] CTD PMID:28688122 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016 		JBrowse link
G Agt angiotensinogen multiple interactions
decreases response to substance
decreases activity		 ISO
EXP		 [olmesartan co-treated with PD 123319] inhibits the reaction [AGT protein modified form results in increased abundance of Fatty Acids, Nonesterified]; [olmesartan co-treated with PD 123319] inhibits the reaction [AGT protein modified form results in increased secretion of and results in increased abundance of Triglycerides]; PD 123319 inhibits the reaction [AGT protein results in increased expression of MDM2 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of MDM2 protein]
PD 123319 results in decreased susceptibility to AGT protein
PD 123319 results in decreased activity of AGT protein modified form
PD 123319 affects the reaction [AGT protein promotes the reaction [PTPN6 protein binds to MTUS1 protein]]; PD 123319 inhibits the reaction [AGT protein results in increased abundance of Nitric Oxide]; PD 123319 inhibits the reaction [AGT protein results in increased expression of ANGPT1 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of ANGPT2 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of EDN1 protein]; PD 123319 inhibits the reaction [AGT protein results in increased expression of KDR mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of MAP2 protein]; PD 123319 inhibits the reaction [AGT protein results in increased expression of SPP1 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of SPP1 protein]; PD 123319 inhibits the reaction [AGT protein results in increased expression of TEK mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of TUBB3 protein]; PD 123319 inhibits the reaction [AGT protein results in increased expression of UBE2V2 protein]; PD 123319 inhibits the reaction [AGT protein results in increased expression of VEGFA mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of VEGFA protein]; PD 123319 promotes the reaction [AGT protein results in increased abundance of Prostaglandins E]
PD 123319 inhibits the reaction [AGT protein results in increased expression of UBE2V2 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of UBE2V2 protein]; PD 123319 inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; PD 123319 inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 protein]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX2 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX2 protein]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX4 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP mRNA]]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP protein]]]; PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [[AGT protein co-treated with Rotenone] results in increased expression of AGTR2 protein]]; PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTR2 mRNA]]]		 CTD PMID:9176287 PMID:9519251 PMID:11115077 PMID:14597853 PMID:14638905 PMID:14718351 PMID:15007106 PMID:16003179 PMID:16769992 PMID:17068200 PMID:18206046 PMID:18300857 PMID:19041135 PMID:19246637 PMID:25446015 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions
decreases activity
increases expression
decreases expression		 ISO
EXP		 [PD 123319 binds to and results in decreased activity of AGTR2 protein] inhibits the reaction [candesartan results in increased expression of NOS3 protein]; PD 123319 binds to and results in decreased activity of AGTR2 protein
PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [[AGT protein co-treated with Rotenone] results in increased expression of AGTR2 protein]]; PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTR2 mRNA]]]
PD 123319 results in decreased activity of AGTR2 protein
PD 123319 results in increased expression of AGTR2 mRNA; PD 123319 results in increased expression of AGTR2 protein
PD 123319 results in decreased expression of AGTR2 mRNA
[PD 123319 binds to and results in decreased activity of AGTR2 protein] which affects the susceptibility to Phenylephrine; [PD 123319 results in decreased activity of AGTR2 protein] inhibits the reaction [Valsartan results in increased abundance of Cyclic GMP]; [PD 123319 results in decreased activity of AGTR2 protein] which results in decreased susceptibility to Estradiol; [PD 123319 results in decreased activity of AGTR2 protein] which results in decreased susceptibility to Valsartan; PD 123319 binds to and results in decreased activity of AGTR2 protein		 CTD PMID:9336375 PMID:9740612 PMID:11509473 PMID:11893553 PMID:15807884 PMID:16982965 PMID:18300857 PMID:18388195 PMID:18551021 PMID:19151255 PMID:25446015 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842 		JBrowse link
G Agtrap angiotensin II receptor-associated protein multiple interactions ISO PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP mRNA]]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP protein]]] CTD PMID:25446015 NCBI chr 5:164,888,069...164,898,387
Ensembl chr 5:164,886,813...164,898,420 		JBrowse link
G Angpt1 angiopoietin 1 multiple interactions EXP PD 123319 inhibits the reaction [AGT protein results in increased expression of ANGPT1 mRNA] CTD PMID:14638905 NCBI chr 7:81,338,327...81,592,459
Ensembl chr 7:81,342,280...81,592,206 		JBrowse link
G Angpt2 angiopoietin 2 multiple interactions EXP PD 123319 inhibits the reaction [AGT protein results in increased expression of ANGPT2 mRNA] CTD PMID:14638905 NCBI chr16:75,966,480...76,016,147
Ensembl chr16:75,966,352...76,016,195 		JBrowse link
G Bdkrb2 bradykinin receptor B2 multiple interactions ISO PD 123319 affects the reaction [BDKRB2 affects the abundance of 6-Ketoprostaglandin F1 alpha] CTD PMID:16514058 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP PD 123319 inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA] CTD PMID:15284299 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions EXP PD 123319 inhibits the reaction [Ethylene Glycol results in increased expression of CCL5 protein] CTD PMID:16284884 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX2 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX2 protein]] CTD PMID:25446015 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547 		JBrowse link
G Edn1 endothelin 1 multiple interactions EXP PD 123319 inhibits the reaction [AGT protein results in increased expression of EDN1 protein] CTD PMID:15007106 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324 		JBrowse link
G Kdr kinase insert domain receptor multiple interactions EXP PD 123319 inhibits the reaction [AGT protein results in increased expression of KDR mRNA] CTD PMID:14638905 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183 		JBrowse link
G Kng2 kininogen 2 multiple interactions EXP
ISO		 PD 123319 inhibits the reaction [benazepril promotes the reaction [Valsartan results in increased expression of KNG1 protein modified form]]; PD 123319 inhibits the reaction [Valsartan promotes the reaction [benazepril results in increased expression of KNG1 protein modified form]]
PD 123319 affects the reaction [KNG1 affects the abundance of Nitric Oxide]		 CTD PMID:11509473 PMID:16514058 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions EXP PD 123319 inhibits the reaction [AGT protein results in increased expression of MAP2 protein] CTD PMID:17068200 NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO PD 123319 inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein] CTD PMID:19041135 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO PD 123319 inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein] CTD PMID:19041135 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions ISO PD 123319 inhibits the reaction [AGT protein results in increased expression of MDM2 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of MDM2 protein] CTD PMID:18206046 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328 		JBrowse link
G Mtus1 microtubule associated scaffold protein 1 multiple interactions EXP PD 123319 affects the reaction [AGT protein promotes the reaction [PTPN6 protein binds to MTUS1 protein]] CTD PMID:17068200 NCBI chr16:54,240,892...54,386,131
Ensembl chr16:54,291,251...54,386,129 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP PD 123319 inhibits the reaction [Ethylene Glycol results in increased expression of NFKB1 protein] CTD PMID:16284884 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO [PD 123319 binds to and results in decreased activity of AGTR2 protein] inhibits the reaction [candesartan results in increased expression of NOS3 protein] CTD PMID:18551021 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions ISO PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 protein]] CTD PMID:25446015 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX4 mRNA]] CTD PMID:25446015 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194 		JBrowse link
G Prkce protein kinase C, epsilon increases expression EXP PD 123319 results in increased expression of PRKCE protein CTD PMID:11893553 NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 multiple interactions EXP PD 123319 affects the reaction [AGT protein promotes the reaction [PTPN6 protein binds to MTUS1 protein]] CTD PMID:17068200 NCBI chr 4:157,239,141...157,263,890
Ensembl chr 4:157,239,142...157,263,890 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP PD 123319 inhibits the reaction [AGT protein results in increased expression of SPP1 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of SPP1 protein] CTD PMID:11115077 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901 		JBrowse link
G Tek TEK receptor tyrosine kinase multiple interactions EXP PD 123319 inhibits the reaction [AGT protein results in increased expression of TEK mRNA] CTD PMID:14638905 NCBI chr 5:113,725,717...113,852,799
Ensembl chr 5:113,725,717...113,852,799 		JBrowse link
G Tubb3 tubulin, beta 3 class III multiple interactions EXP PD 123319 inhibits the reaction [AGT protein results in increased expression of TUBB3 protein] CTD PMID:17068200 NCBI chr19:56,220,759...56,229,813
Ensembl chr19:56,220,755...56,229,813 		JBrowse link
G Ube2v2 ubiquitin conjugating enzyme E2 V2 multiple interactions ISO
EXP		 PD 123319 inhibits the reaction [AGT protein results in increased expression of UBE2V2 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of UBE2V2 protein] CTD PMID:16769992 PMID:17068200 NCBI chr11:89,557,273...89,591,175
Ensembl chr11:89,557,273...89,591,175 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP PD 123319 inhibits the reaction [AGT protein results in increased expression of VEGFA mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of VEGFA protein]; PD 123319 inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]; PD 123319 inhibits the reaction [Streptozocin results in increased expression of VEGFA protein] CTD PMID:14638905 PMID:14718351 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19767
    role 19714
      biological role 19714
        pharmacological role 18831
          antagonist 16284
            hormone antagonist 11551
              endothelin receptor antagonist 253
                ACT-132577 + 4
                PD123319 29
                bosentan + 87
                endothelin A receptor antagonist 0
                enrasentan 2
                losartan + 168
                macitentan 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19767
    role 19714
      application 19403
        pharmaceutical 19303
          drug 19303
            receptor modulator 18866
              hormone receptor modulator 18855
                hormone antagonist 11551
                  endothelin receptor antagonist 253
                    ACT-132577 + 4
                    PD123319 29
                    bosentan + 87
                    endothelin A receptor antagonist 0
                    enrasentan 2
                    losartan + 168
                    macitentan 4
paths to the root