CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: fomepizole
Accession: CHEBI:5141
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Definition: A member of the class of pyrazoles that is 1H-pyrazole substituted by a methyl group at position 4.
Synonyms: exact_synonym: 4-methyl-1H-pyrazole
related_synonym: 4-Methylpyrazol; 4-Methylpyrazole; Antizol; Formula=C4H6N2; InChI=1S/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6); InChIKey=RIKMMFOAQPJVMX-UHFFFAOYSA-N; SMILES=Cc1cn[nH]c1; fomepizol; fomepizolum
xref: Beilstein:105204; CAS:7554-65-6; DrugBank:DB01213; Drug_Central:1233; HMDB:HMDB0015344; KEGG:C07837; KEGG:D00707; LINCS:LSM-5671
xref_mesh: MESH:C010238
xref: PDBeChem:4PZ; PMID:11172179; PMID:11899949; PMID:16035197; PMID:22554311; Reaxys:105204; Wikipedia:Fomepizole
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Adh1
alcohol dehydrogenase 1 (class I)
decreases activity multiple interactions
EXP ISO
fomepizole results in decreased activity of ADH1 protein fomepizole inhibits the reaction [ADH1C protein results in increased oxidation of Ethanol]
CTD
PMID:7943667 PMID:21167143
NCBI chr 3:137,983,346...137,996,459
Ensembl chr 3:137,966,752...137,996,459
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Adh4
alcohol dehydrogenase 4 (class II), pi polypeptide
multiple interactions
ISO
fomepizole inhibits the reaction [ADH4 protein results in increased oxidation of Ethanol]
CTD
PMID:21167143
NCBI chr 3:138,121,217...138,138,444
Ensembl chr 3:138,121,227...138,136,653
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Adh7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
multiple interactions
ISO
fomepizole inhibits the reaction [ADH7 protein results in increased oxidation of Ethanol]
CTD
PMID:21167143
NCBI chr 3:137,903,828...137,937,803
Ensembl chr 3:137,923,521...137,939,143
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Aifm1
apoptosis-inducing factor, mitochondrion-associated 1
multiple interactions
EXP
Fomepizole inhibits the reaction [Acetaminophen affects the localization of AIFM1 protein]
CTD
PMID:29739258
NCBI chr X:47,563,821...47,602,440
Ensembl chr X:47,563,821...47,602,440
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Bax
BCL2-associated X protein
multiple interactions
EXP
Fomepizole inhibits the reaction [Acetaminophen affects the localization of BAX protein]
CTD
PMID:29739258
NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
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Casp12
caspase 12
multiple interactions
EXP
Fomepizole inhibits the reaction [Acetaminophen results in increased cleavage of CASP12 protein]
CTD
PMID:38042273
NCBI chr 9:5,345,419...5,373,034
Ensembl chr 9:5,345,430...5,373,032
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Ccn2
cellular communication network factor 2
multiple interactions
EXP
Fomepizole inhibits the reaction [Ethanol results in increased expression of CCN2 mRNA]; Fomepizole inhibits the reaction [Ethanol results in increased expression of CCN2 protein]
CTD
PMID:19280452
NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581
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Col1a1
collagen, type I, alpha 1
multiple interactions
ISO
fomepizole inhibits the reaction [Ethanol results in increased expression of COL1A1 mRNA]
CTD
PMID:9540844
NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868
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Cxcl2
C-X-C motif chemokine ligand 2
multiple interactions
ISO
fomepizole inhibits the reaction [Ethanol results in increased expression of CXCL2 mRNA]
CTD
PMID:20116195
NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
multiple interactions increases expression increases activity decreases activity
ISO EXP
[fomepizole results in decreased activity of CYP2E1 protein] which results in decreased metabolism of vinyl fluoride; fomepizole inhibits the reaction [[CYP2E1 protein results in increased metabolism of Ethanol] which results in increased abundance of Reactive Oxygen Species]; fomepizole inhibits the reaction [Carbon Tetrachloride inhibits the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]]; fomepizole inhibits the reaction [Carbon Tetrachloride results in increased degradation of CYP2E1 protein]; fomepizole inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]; fomepizole inhibits the reaction [CYP2E1 protein affects the metabolism of 2,6-xylidine metabolite]; fomepizole inhibits the reaction [CYP2E1 protein results in increased chemical synthesis of 6-hydroxychlorzoxazone]; fomepizole inhibits the reaction [CYP2E1 protein results in increased metabolism of Chlorzoxazone] fomepizole results in increased expression of CYP2E1 protein [fomepizole results in decreased activity of CYP2E1 protein] which results in decreased uptake of vinyl fluoride; fomepizole promotes the reaction [CYP2E1 protein results in increased metabolism of methylformamide] fomepizole results in increased activity of CYP2E1 protein Fomepizole results in decreased activity of CYP2E1 protein
CTD
PMID:1538706 PMID:3113478 PMID:3782137 PMID:8074729 PMID:8531136 PMID:9073601 PMID:9143349 PMID:11409937 PMID:18845238 PMID:21336516 PMID:21915887 PMID:24561005 PMID:33253783 More...
NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
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Cyp4a12b
cytochrome P450, family 4, subfamily a, polypeptide 12B
increases expression multiple interactions
ISO
fomepizole results in increased expression of CYP4A1 protein fomepizole promotes the reaction [Ethanol results in increased expression of CYP4A1 protein]
CTD
PMID:20116195
NCBI chr 4:115,268,821...115,296,231
Ensembl chr 4:115,268,821...115,296,231
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Ddit3
DNA-damage inducible transcript 3
multiple interactions
EXP
Fomepizole inhibits the reaction [Acetaminophen results in increased expression of DDIT3 protein]
CTD
PMID:38042273
NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157 Ensembl chr10:127,126,643...127,132,157
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Diablo
diablo, IAP-binding mitochondrial protein
multiple interactions
EXP
Fomepizole inhibits the reaction [Acetaminophen affects the localization of DIABLO protein]
CTD
PMID:29739258
NCBI chr 5:123,649,393...123,664,825
Ensembl chr 5:123,647,828...123,662,239
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Gpt
glutamic pyruvic transaminase, soluble
multiple interactions
ISO EXP
fomepizole inhibits the reaction [Caffeine promotes the reaction [allyl alcohol results in increased activity of GPT protein]] Fomepizole inhibits the reaction [Acetaminophen results in increased activity of GPT protein]; Fomepizole inhibits the reaction [leupeptin promotes the reaction [Acetaminophen results in increased activity of GPT protein]]
CTD
PMID:11394713 PMID:29739258 PMID:33458793 PMID:38042273
NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
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H2ax
H2A.X variant histone
multiple interactions
ISO
Fomepizole inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein]
CTD
PMID:28300663
NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374
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Hamp
hepcidin antimicrobial peptide
multiple interactions
ISO
fomepizole inhibits the reaction [Ethanol results in decreased expression of HAMP mRNA]
CTD
PMID:16737972
NCBI chr 7:30,641,793...30,643,454
Ensembl chr 7:30,641,793...30,643,457
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Il4
interleukin 4
multiple interactions decreases expression
ISO
Ethanol inhibits the reaction [fomepizole results in decreased expression of IL4 mRNA]; fomepizole inhibits the reaction [Ethanol results in decreased expression of IL4 mRNA]
CTD
PMID:20116195
NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
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Itpr1
inositol 1,4,5-trisphosphate receptor 1
multiple interactions
ISO
fomepizole inhibits the reaction [Ethanol results in increased expression of and affects the localization of ITPR1 protein]
CTD
PMID:17241155
NCBI chr 6:108,190,044...108,528,077
Ensembl chr 6:108,190,057...108,528,070
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Lcn2
lipocalin 2
multiple interactions
EXP
Fomepizole inhibits the reaction [Acetaminophen results in increased expression of LCN2 protein]
CTD
PMID:38042273
NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264
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Ldha
lactate dehydrogenase A
multiple interactions
ISO
Fomepizole inhibits the reaction [Acetaminophen results in decreased activity of LDHA protein]
CTD
PMID:38042273
NCBI chr 7:46,491,698...46,505,051
Ensembl chr 7:46,490,899...46,505,051
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Map1lc3b
microtubule-associated protein 1 light chain 3 beta
multiple interactions
EXP
fomepizole inhibits the reaction [Ethanol results in increased lipidation of MAP1LC3B protein]
CTD
PMID:24492484
NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499
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Mapk1
mitogen-activated protein kinase 1
multiple interactions
EXP
fomepizole inhibits the reaction [Ethanol results in decreased phosphorylation of MAPK1 protein]
CTD
PMID:18317950
NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
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Mapk3
mitogen-activated protein kinase 3
multiple interactions
EXP
fomepizole inhibits the reaction [Ethanol results in decreased phosphorylation of MAPK3 protein]
CTD
PMID:18317950
NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
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Mapk8
mitogen-activated protein kinase 8
multiple interactions affects binding
EXP
Fomepizole inhibits the reaction [Acetaminophen results in increased phosphorylation of and affects the localization of MAPK8 protein] Fomepizole binds to MAPK8 protein
CTD
PMID:29739258 PMID:30903181
NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
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Mapk9
mitogen-activated protein kinase 9
affects binding
EXP
Fomepizole binds to MAPK9 protein
CTD
PMID:30903181
NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248
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Oprk1
opioid receptor, kappa 1
multiple interactions
ISO
fomepizole inhibits the reaction [Ethanol results in decreased expression of OPRK1 mRNA]
CTD
PMID:17934066
NCBI chr 1:5,658,673...5,676,357
Ensembl chr 1:5,658,689...5,676,354
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Pdgfrb
platelet derived growth factor receptor, beta polypeptide
multiple interactions
ISO
fomepizole inhibits the reaction [Ethanol results in increased expression of PDGFRB mRNA]
CTD
PMID:20116195
NCBI chr18:61,178,194...61,218,139
Ensembl chr18:61,178,222...61,218,133
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Pdyn
prodynorphin
multiple interactions
ISO
fomepizole inhibits the reaction [Ethanol results in decreased expression of PDYN mRNA]
CTD
PMID:17934066
NCBI chr 2:129,528,469...129,541,858
Ensembl chr 2:129,528,485...129,541,764
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Penk
preproenkephalin
multiple interactions
ISO
fomepizole inhibits the reaction [Ethanol results in decreased expression of PENK mRNA]
CTD
PMID:17934066
NCBI chr 4:4,133,536...4,138,815
Ensembl chr 4:4,133,531...4,138,819
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Pomc
pro-opiomelanocortin-alpha
multiple interactions
ISO
fomepizole inhibits the reaction [Ethanol results in decreased expression of POMC mRNA]
CTD
PMID:17934066
NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642
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Ppara
peroxisome proliferator activated receptor alpha
multiple interactions
ISO
fomepizole inhibits the reaction [Ethanol results in decreased activity of PPARA protein]
CTD
PMID:11022051
NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
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Pparg
peroxisome proliferator activated receptor gamma
multiple interactions
ISO
fomepizole inhibits the reaction [Ethanol inhibits the reaction [rosiglitazone results in increased activity of PPARG protein]]
CTD
PMID:17030193
NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
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Prkcd
protein kinase C, delta
multiple interactions
ISO
fomepizole inhibits the reaction [allyl alcohol affects the localization of PRKCD protein]
CTD
PMID:12755590
NCBI chr14:30,317,310...30,348,637
Ensembl chr14:30,317,311...30,348,167
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Tnf
tumor necrosis factor
multiple interactions
ISO
fomepizole inhibits the reaction [Ethanol results in increased expression of TNF mRNA]
CTD
PMID:20116195
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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Trib3
tribbles pseudokinase 3
multiple interactions
ISO
fomepizole inhibits the reaction [Ethanol results in increased expression of TRIB3 mRNA]
CTD
PMID:20116195
NCBI chr 2:152,179,345...152,185,980
Ensembl chr 2:152,179,342...152,185,952
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