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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fomepizole
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Accession:CHEBI:5141 term browser browse the term
Definition:A member of the class of pyrazoles that is 1H-pyrazole substituted by a methyl group at position 4.
Synonyms:exact_synonym: 4-methyl-1H-pyrazole
 related_synonym: 4-Methylpyrazol;   4-Methylpyrazole;   Antizol;   Formula=C4H6N2;   InChI=1S/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6);   InChIKey=RIKMMFOAQPJVMX-UHFFFAOYSA-N;   SMILES=Cc1cn[nH]c1;   fomepizol;   fomepizolum
 xref: Beilstein:105204;   CAS:7554-65-6;   DrugBank:DB01213;   Drug_Central:1233;   HMDB:HMDB0015344;   KEGG:C07837;   KEGG:D00707;   LINCS:LSM-5671
 xref_mesh: MESH:C010238
 xref: PDBeChem:4PZ;   PMID:11172179;   PMID:11899949;   PMID:16035197;   PMID:22554311;   Reaxys:105204;   Wikipedia:Fomepizole



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fomepizole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh1 alcohol dehydrogenase 1 (class I) decreases activity
multiple interactions
EXP
ISO
fomepizole results in decreased activity of ADH1 protein
fomepizole inhibits the reaction [ADH1C protein results in increased oxidation of Ethanol]
CTD PMID:7943667 PMID:21167143 NCBI chr 3:137,983,346...137,996,459
Ensembl chr 3:137,966,752...137,996,459
JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide multiple interactions ISO fomepizole inhibits the reaction [ADH4 protein results in increased oxidation of Ethanol] CTD PMID:21167143 NCBI chr 3:138,121,217...138,138,444
Ensembl chr 3:138,121,227...138,136,653
JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide multiple interactions ISO fomepizole inhibits the reaction [ADH7 protein results in increased oxidation of Ethanol] CTD PMID:21167143 NCBI chr 3:137,903,828...137,937,803
Ensembl chr 3:137,923,521...137,939,143
JBrowse link
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 multiple interactions EXP Fomepizole inhibits the reaction [Acetaminophen affects the localization of AIFM1 protein] CTD PMID:29739258 NCBI chr  X:47,563,821...47,602,440
Ensembl chr  X:47,563,821...47,602,440
JBrowse link
G Bax BCL2-associated X protein multiple interactions EXP Fomepizole inhibits the reaction [Acetaminophen affects the localization of BAX protein] CTD PMID:29739258 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Casp12 caspase 12 multiple interactions EXP Fomepizole inhibits the reaction [Acetaminophen results in increased cleavage of CASP12 protein] CTD PMID:38042273 NCBI chr 9:5,345,419...5,373,034
Ensembl chr 9:5,345,430...5,373,032
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions EXP Fomepizole inhibits the reaction [Ethanol results in increased expression of CCN2 mRNA]; Fomepizole inhibits the reaction [Ethanol results in increased expression of CCN2 protein] CTD PMID:19280452 NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581
JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in increased expression of COL1A1 mRNA] CTD PMID:9540844 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in increased expression of CXCL2 mRNA] CTD PMID:20116195 NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression
increases activity
decreases activity
ISO
EXP
[fomepizole results in decreased activity of CYP2E1 protein] which results in decreased metabolism of vinyl fluoride; fomepizole inhibits the reaction [[CYP2E1 protein results in increased metabolism of Ethanol] which results in increased abundance of Reactive Oxygen Species]; fomepizole inhibits the reaction [Carbon Tetrachloride inhibits the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]]; fomepizole inhibits the reaction [Carbon Tetrachloride results in increased degradation of CYP2E1 protein]; fomepizole inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]; fomepizole inhibits the reaction [CYP2E1 protein affects the metabolism of 2,6-xylidine metabolite]; fomepizole inhibits the reaction [CYP2E1 protein results in increased chemical synthesis of 6-hydroxychlorzoxazone]; fomepizole inhibits the reaction [CYP2E1 protein results in increased metabolism of Chlorzoxazone]
fomepizole results in increased expression of CYP2E1 protein
[fomepizole results in decreased activity of CYP2E1 protein] which results in decreased uptake of vinyl fluoride; fomepizole promotes the reaction [CYP2E1 protein results in increased metabolism of methylformamide]
fomepizole results in increased activity of CYP2E1 protein
Fomepizole results in decreased activity of CYP2E1 protein
CTD PMID:1538706 PMID:3113478 PMID:3782137 PMID:8074729 PMID:8531136 More... NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
JBrowse link
G Cyp4a12b cytochrome P450, family 4, subfamily a, polypeptide 12B increases expression
multiple interactions
ISO fomepizole results in increased expression of CYP4A1 protein
fomepizole promotes the reaction [Ethanol results in increased expression of CYP4A1 protein]
CTD PMID:20116195 NCBI chr 4:115,268,821...115,296,231
Ensembl chr 4:115,268,821...115,296,231
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP Fomepizole inhibits the reaction [Acetaminophen results in increased expression of DDIT3 protein] CTD PMID:38042273 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein multiple interactions EXP Fomepizole inhibits the reaction [Acetaminophen affects the localization of DIABLO protein] CTD PMID:29739258 NCBI chr 5:123,649,393...123,664,825
Ensembl chr 5:123,647,828...123,662,239
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions ISO
EXP
fomepizole inhibits the reaction [Caffeine promotes the reaction [allyl alcohol results in increased activity of GPT protein]]
Fomepizole inhibits the reaction [Acetaminophen results in increased activity of GPT protein]; Fomepizole inhibits the reaction [leupeptin promotes the reaction [Acetaminophen results in increased activity of GPT protein]]
CTD PMID:11394713 PMID:29739258 PMID:33458793 PMID:38042273 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO Fomepizole inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein] CTD PMID:28300663 NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374
JBrowse link
G Hamp hepcidin antimicrobial peptide multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in decreased expression of HAMP mRNA] CTD PMID:16737972 NCBI chr 7:30,641,793...30,643,454
Ensembl chr 7:30,641,793...30,643,457
JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression
ISO Ethanol inhibits the reaction [fomepizole results in decreased expression of IL4 mRNA]; fomepizole inhibits the reaction [Ethanol results in decreased expression of IL4 mRNA] CTD PMID:20116195 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor 1 multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in increased expression of and affects the localization of ITPR1 protein] CTD PMID:17241155 NCBI chr 6:108,190,044...108,528,077
Ensembl chr 6:108,190,057...108,528,070
JBrowse link
G Lcn2 lipocalin 2 multiple interactions EXP Fomepizole inhibits the reaction [Acetaminophen results in increased expression of LCN2 protein] CTD PMID:38042273 NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264
JBrowse link
G Ldha lactate dehydrogenase A multiple interactions ISO Fomepizole inhibits the reaction [Acetaminophen results in decreased activity of LDHA protein] CTD PMID:38042273 NCBI chr 7:46,491,698...46,505,051
Ensembl chr 7:46,490,899...46,505,051
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions EXP fomepizole inhibits the reaction [Ethanol results in increased lipidation of MAP1LC3B protein] CTD PMID:24492484 NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions EXP fomepizole inhibits the reaction [Ethanol results in decreased phosphorylation of MAPK1 protein] CTD PMID:18317950 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions EXP fomepizole inhibits the reaction [Ethanol results in decreased phosphorylation of MAPK3 protein] CTD PMID:18317950 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
affects binding
EXP Fomepizole inhibits the reaction [Acetaminophen results in increased phosphorylation of and affects the localization of MAPK8 protein]
Fomepizole binds to MAPK8 protein
CTD PMID:29739258 PMID:30903181 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 affects binding EXP Fomepizole binds to MAPK9 protein CTD PMID:30903181 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248
JBrowse link
G Oprk1 opioid receptor, kappa 1 multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in decreased expression of OPRK1 mRNA] CTD PMID:17934066 NCBI chr 1:5,658,673...5,676,357
Ensembl chr 1:5,658,689...5,676,354
JBrowse link
G Pdgfrb platelet derived growth factor receptor, beta polypeptide multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in increased expression of PDGFRB mRNA] CTD PMID:20116195 NCBI chr18:61,178,194...61,218,139
Ensembl chr18:61,178,222...61,218,133
JBrowse link
G Pdyn prodynorphin multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in decreased expression of PDYN mRNA] CTD PMID:17934066 NCBI chr 2:129,528,469...129,541,858
Ensembl chr 2:129,528,485...129,541,764
JBrowse link
G Penk preproenkephalin multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in decreased expression of PENK mRNA] CTD PMID:17934066 NCBI chr 4:4,133,536...4,138,815
Ensembl chr 4:4,133,531...4,138,819
JBrowse link
G Pomc pro-opiomelanocortin-alpha multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in decreased expression of POMC mRNA] CTD PMID:17934066 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in decreased activity of PPARA protein] CTD PMID:11022051 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions ISO fomepizole inhibits the reaction [Ethanol inhibits the reaction [rosiglitazone results in increased activity of PPARG protein]] CTD PMID:17030193 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO fomepizole inhibits the reaction [allyl alcohol affects the localization of PRKCD protein] CTD PMID:12755590 NCBI chr14:30,317,310...30,348,637
Ensembl chr14:30,317,311...30,348,167
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in increased expression of TNF mRNA] CTD PMID:20116195 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Trib3 tribbles pseudokinase 3 multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in increased expression of TRIB3 mRNA] CTD PMID:20116195 NCBI chr 2:152,179,345...152,185,980
Ensembl chr 2:152,179,342...152,185,952
JBrowse link

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  CHEBI ontology 22188
    role 22173
      application 21755
        pharmaceutical 21163
          drug 21163
            protective agent 18644
              fomepizole 35
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  CHEBI ontology 22188
    subatomic particle 22180
      composite particle 22180
        hadron 22180
          baryon 22180
            nucleon 22180
              atomic nucleus 22180
                atom 22180
                  main group element atom 22114
                    p-block element atom 22114
                      carbon group element atom 21915
                        carbon atom 21840
                          organic molecular entity 21840
                            organic molecule 21654
                              organic cyclic compound 21259
                                organic heterocyclic compound 20336
                                  heteroarene 17895
                                    monocyclic heteroarene 15313
                                      azole 14850
                                        diazole 10547
                                          pyrazoles 2348
                                            pyrazole 1613
                                              1H-pyrazole 1613
                                                fomepizole 35
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