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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fomepizole
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Accession:CHEBI:5141 term browser browse the term
Definition:A member of the class of pyrazoles that is 1H-pyrazole substituted by a methyl group at position 4.
Synonyms:exact_synonym: 4-methyl-1H-pyrazole
 related_synonym: 4-Methylpyrazol;   4-Methylpyrazole;   Antizol;   Formula=C4H6N2;   InChI=1S/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6);   InChIKey=RIKMMFOAQPJVMX-UHFFFAOYSA-N;   SMILES=Cc1cn[nH]c1;   fomepizol;   fomepizolum
 xref: Beilstein:105204;   CAS:7554-65-6;   DrugBank:DB01213;   Drug_Central:1233;   HMDB:HMDB0015344;   KEGG:C07837;   KEGG:D00707;   LINCS:LSM-5671
 xref_mesh: MESH:C010238
 xref: PDBeChem:4PZ;   PMID:11172179;   PMID:11899949;   PMID:16035197;   PMID:22554311;   Reaxys:105204;   Wikipedia:Fomepizole


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fomepizole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh1 alcohol dehydrogenase 1 (class I) decreases activity
multiple interactions
ISO fomepizole results in decreased activity of ADH1 protein
fomepizole inhibits the reaction [ADH1C protein results in increased oxidation of Ethanol]
CTD PMID:7943667, PMID:21167143 NCBI chr 2:243,550,655...243,562,243
Ensembl chr 2:243,550,627...243,687,857
JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide multiple interactions ISO fomepizole inhibits the reaction [ADH4 protein results in increased oxidation of Ethanol] CTD PMID:21167143 NCBI chr 2:243,702,035...243,720,063
Ensembl chr 2:243,700,784...243,740,899
JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide multiple interactions ISO fomepizole inhibits the reaction [ADH7 protein results in increased oxidation of Ethanol] CTD PMID:21167143 NCBI chr 2:243,500,540...243,516,865
Ensembl chr 2:243,502,073...243,516,532
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO Fomepizole inhibits the reaction [Ethanol results in increased expression of CCN2 mRNA]; Fomepizole inhibits the reaction [Ethanol results in increased expression of CCN2 protein] CTD PMID:19280452 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP fomepizole inhibits the reaction [Ethanol results in increased expression of COL1A1 mRNA] CTD PMID:9540844 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions EXP fomepizole inhibits the reaction [Ethanol results in increased expression of CXCL2 mRNA] CTD PMID:20116195 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity
increases expression
increases activity
ISO
EXP
[Fomepizole results in decreased activity of CYP2E1 protein] which results in decreased metabolism of vinyl fluoride; Fomepizole inhibits the reaction [[CYP2E1 protein results in increased metabolism of Ethanol] which results in increased abundance of Reactive Oxygen Species]; Fomepizole inhibits the reaction [Carbon Tetrachloride inhibits the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]]; Fomepizole inhibits the reaction [Carbon Tetrachloride results in increased degradation of CYP2E1 protein]; Fomepizole inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]; Fomepizole inhibits the reaction [CYP2E1 protein affects the metabolism of 2,6-xylidine metabolite]; Fomepizole inhibits the reaction [CYP2E1 protein results in increased chemical synthesis of 6-hydroxychlorzoxazone]; Fomepizole inhibits the reaction [CYP2E1 protein results in increased metabolism of Chlorzoxazone]
fomepizole results in decreased activity of CYP2E1 protein
fomepizole results in increased expression of CYP2E1 protein
fomepizole results in increased activity of CYP2E1 protein
[fomepizole results in decreased activity of CYP2E1 protein] which results in decreased uptake of vinyl fluoride
[fomepizole results in decreased activity of CYP2E1 protein] which results in decreased uptake of vinyl fluoride; fomepizole promotes the reaction [CYP2E1 protein results in increased metabolism of methylformamide]
CTD PMID:1538706, PMID:3113478, PMID:3782137, PMID:8074729, PMID:8531136, PMID:9073601, PMID:9143349, PMID:11409937, PMID:18845238, PMID:21336516, PMID:21915887, PMID:24561005 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 multiple interactions
increases expression
EXP fomepizole promotes the reaction [Ethanol results in increased expression of CYP4A1 protein]
fomepizole results in increased expression of CYP4A1 protein
CTD PMID:20116195 NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP fomepizole inhibits the reaction [Caffeine promotes the reaction [allyl alcohol results in increased activity of GPT protein]] CTD PMID:11394713 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO Fomepizole inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein] CTD PMID:28300663 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hamp hepcidin antimicrobial peptide multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in decreased expression of HAMP mRNA] CTD PMID:16737972 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression
EXP Ethanol inhibits the reaction [fomepizole results in decreased expression of IL4 mRNA]; fomepizole inhibits the reaction [Ethanol results in decreased expression of IL4 mRNA] CTD PMID:20116195 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in increased expression of and affects the localization of ITPR1 protein] CTD PMID:17241155 NCBI chr 4:140,247,297...140,580,749
Ensembl chr 4:140,247,313...140,580,748
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in increased lipidation of MAP1LC3B protein] CTD PMID:24492484 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in decreased phosphorylation of MAPK1 protein] CTD PMID:18317950 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in decreased phosphorylation of MAPK3 protein] CTD PMID:18317950 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 affects binding
multiple interactions
ISO Fomepizole binds to MAPK8 protein
Fomepizole inhibits the reaction [Acetaminophen results in increased phosphorylation of and affects the localization of MAPK8 protein]
CTD PMID:30903181 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 affects binding ISO Fomepizole binds to MAPK9 protein CTD PMID:30903181 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Oprk1 opioid receptor, kappa 1 multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in decreased expression of OPRK1 mRNA] CTD PMID:17934066 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions EXP fomepizole inhibits the reaction [Ethanol results in increased expression of PDGFRB mRNA] CTD PMID:20116195 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
JBrowse link
G Pdyn prodynorphin multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in decreased expression of PDYN mRNA] CTD PMID:17934066 NCBI chr 3:122,194,327...122,206,671
Ensembl chr 3:122,194,329...122,206,671
JBrowse link
G Penk proenkephalin multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in decreased expression of PENK mRNA] CTD PMID:17934066 NCBI chr 5:17,056,412...17,061,762
Ensembl chr 5:17,056,419...17,061,837
JBrowse link
G Pomc proopiomelanocortin multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in decreased expression of POMC mRNA] CTD PMID:17934066 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP fomepizole inhibits the reaction [Ethanol results in decreased activity of PPARA protein] CTD PMID:11022051 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO fomepizole inhibits the reaction [Ethanol inhibits the reaction [rosiglitazone results in increased activity of PPARG protein]] CTD PMID:17030193 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Prkcd protein kinase C, delta multiple interactions EXP fomepizole inhibits the reaction [allyl alcohol affects the localization of PRKCD protein] CTD PMID:12755590 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP fomepizole inhibits the reaction [Ethanol results in increased expression of TNF mRNA] CTD PMID:20116195 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trib3 tribbles pseudokinase 3 multiple interactions EXP fomepizole inhibits the reaction [Ethanol results in increased expression of TRIB3 mRNA] CTD PMID:20116195 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19718
      application 19363
        pharmaceutical 19235
          drug 19235
            protective agent 16342
              fomepizole 28
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    p-block element atom 19655
                      carbon group element atom 19550
                        carbon atom 19539
                          organic molecular entity 19539
                            organic molecule 19461
                              organic cyclic compound 19232
                                organic heterocyclic compound 18404
                                  heteroarene 16443
                                    monocyclic heteroarene 13298
                                      azole 12465
                                        diazole 8125
                                          pyrazoles 1287
                                            pyrazole 925
                                              1H-pyrazole 925
                                                fomepizole 28
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.