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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:doxylamine
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Accession:CHEBI:51380 term browser browse the term
Definition:A tertiary amine that has formula C17H22N2O.
Synonyms:exact_synonym: N,N-dimethyl-2-(1-phenyl-1-pyridin-2-ylethoxy)ethanamine
 related_synonym: 2-(alpha-(2-(Dimethylamino)ethoxy)-alpha-methylbenzyl)pyridine;   2-Dimethylaminoethoxyphenylmethyl-2-picoline;   Dossilamina;   Doxilminio;   Formula=C17H22N2O;   InChI=1S/C17H22N2O/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16/h4-12H,13-14H2,1-3H3;   InChIKey=HCFDWZZGGLSKEP-UHFFFAOYSA-N;   N,N-Dimethyl-2-(1-phenyl-1-(2-pyridinyl)ethoxy)ethanamine;   Phenyl-2-pyridylmethyl-beta-N,N-dimethylaminoethyl ether;   SMILES=CN(C)CCOC(C)(c1ccccc1)c1ccccn1;   doxilamina;   doxylaminum
 xref: Beilstein:230379;   CAS:469-21-6;   DrugBank:DB00366;   Drug_Central:962;   KEGG:D07878;   LINCS:LSM-1563
 xref_mesh: MESH:D004319
 xref: Wikipedia:Doxylamine



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doxylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Doxylamine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Doxylamine binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19803
    role 19779
      biological role 19806
        pharmacological role 19018
          antagonist 17236
            histamine antagonist 4889
              doxylamine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19803
    subatomic particle 19801
      composite particle 19801
        hadron 19830
          baryon 19830
            nucleon 19830
              atomic nucleus 19830
                atom 19801
                  main group element atom 19780
                    main group molecular entity 19780
                      s-block molecular entity 19619
                        hydrogen molecular entity 19606
                          hydrides 19104
                            inorganic hydride 18112
                              pnictogen hydride 18077
                                nitrogen hydride 18008
                                  azane 17818
                                    ammonia 17817
                                      organic amino compound 17793
                                        tertiary amino compound 10127
                                          tertiary amine 642
                                            doxylamine 2
paths to the root