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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:doxylamine
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Accession:CHEBI:51380 term browser browse the term
Definition:A tertiary amine that has formula C17H22N2O.
Synonyms:exact_synonym: N,N-dimethyl-2-(1-phenyl-1-pyridin-2-ylethoxy)ethanamine
 related_synonym: 2-(alpha-(2-(Dimethylamino)ethoxy)-alpha-methylbenzyl)pyridine;   2-Dimethylaminoethoxyphenylmethyl-2-picoline;   Dossilamina;   Doxilminio;   Formula=C17H22N2O;   InChI=1S/C17H22N2O/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16/h4-12H,13-14H2,1-3H3;   InChIKey=HCFDWZZGGLSKEP-UHFFFAOYSA-N;   N,N-Dimethyl-2-(1-phenyl-1-(2-pyridinyl)ethoxy)ethanamine;   Phenyl-2-pyridylmethyl-beta-N,N-dimethylaminoethyl ether;   SMILES=CN(C)CCOC(C)(c1ccccc1)c1ccccn1;   doxilamina;   doxylaminum
 xref: Beilstein:230379;   CAS:469-21-6;   DrugBank:DB00366;   Drug_Central:962;   KEGG:D07878;   LINCS:LSM-1563
 xref_mesh: MESH:D004319
 xref: Wikipedia:Doxylamine



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doxylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Doxylamine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Doxylamine binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19740
    role 19713
      biological role 19711
        pharmacological role 18974
          antagonist 17005
            histamine antagonist 4863
              doxylamine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    main group molecular entity 19686
                      s-block molecular entity 19541
                        hydrogen molecular entity 19534
                          hydrides 19019
                            inorganic hydride 17950
                              pnictogen hydride 17935
                                nitrogen hydride 17832
                                  azane 17616
                                    ammonia 17615
                                      organic amino compound 17615
                                        tertiary amino compound 9927
                                          tertiary amine 628
                                            doxylamine 2
paths to the root