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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:doxylamine
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Accession:CHEBI:51380 term browser browse the term
Definition:A tertiary amine that has formula C17H22N2O.
Synonyms:exact_synonym: N,N-dimethyl-2-(1-phenyl-1-pyridin-2-ylethoxy)ethanamine
 related_synonym: 2-(alpha-(2-(Dimethylamino)ethoxy)-alpha-methylbenzyl)pyridine;   2-Dimethylaminoethoxyphenylmethyl-2-picoline;   Dossilamina;   Doxilminio;   Formula=C17H22N2O;   InChI=1S/C17H22N2O/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16/h4-12H,13-14H2,1-3H3;   InChIKey=HCFDWZZGGLSKEP-UHFFFAOYSA-N;   N,N-Dimethyl-2-(1-phenyl-1-(2-pyridinyl)ethoxy)ethanamine;   Phenyl-2-pyridylmethyl-beta-N,N-dimethylaminoethyl ether;   SMILES=CN(C)CCOC(C)(c1ccccc1)c1ccccn1;   doxilamina;   doxylaminum
 xref: Beilstein:230379;   CAS:469-21-6;   DrugBank:DB00366;   Drug_Central:962;   KEGG:D07878;   LINCS:LSM-1563
 xref_mesh: MESH:D004319
 xref: Wikipedia:Doxylamine


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doxylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Doxylamine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Doxylamine binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        pharmacological role 18793
          antagonist 16194
            histamine antagonist 4602
              doxylamine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            inorganic hydride 17409
                              pnictogen hydride 17381
                                nitrogen hydride 17223
                                  azane 16940
                                    ammonia 16939
                                      organic amino compound 16938
                                        tertiary amino compound 8629
                                          tertiary amine 616
                                            doxylamine 2
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