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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:doxylamine
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Accession:CHEBI:51380 term browser browse the term
Definition:A tertiary amine that has formula C17H22N2O.
Synonyms:exact_synonym: N,N-dimethyl-2-(1-phenyl-1-pyridin-2-ylethoxy)ethanamine
 related_synonym: 2-(alpha-(2-(Dimethylamino)ethoxy)-alpha-methylbenzyl)pyridine;   2-Dimethylaminoethoxyphenylmethyl-2-picoline;   Dossilamina;   Doxilminio;   Formula=C17H22N2O;   InChI=1S/C17H22N2O/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16/h4-12H,13-14H2,1-3H3;   InChIKey=HCFDWZZGGLSKEP-UHFFFAOYSA-N;   N,N-Dimethyl-2-(1-phenyl-1-(2-pyridinyl)ethoxy)ethanamine;   Phenyl-2-pyridylmethyl-beta-N,N-dimethylaminoethyl ether;   SMILES=CN(C)CCOC(C)(c1ccccc1)c1ccccn1;   doxilamina;   doxylaminum
 xref: Beilstein:230379;   CAS:469-21-6;   DrugBank:DB00366;   Drug_Central:962;   KEGG:D07878;   LINCS:LSM-1563
 xref_mesh: MESH:D004319
 xref: Wikipedia:Doxylamine



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doxylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Doxylamine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Doxylamine binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      biological role 19892
        pharmacological role 19111
          antagonist 17213
            histamine antagonist 4894
              doxylamine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    main group molecular entity 19866
                      s-block molecular entity 19698
                        hydrogen molecular entity 19684
                          hydrides 19159
                            inorganic hydride 18151
                              pnictogen hydride 18140
                                nitrogen hydride 18046
                                  azane 17849
                                    ammonia 17848
                                      organic amino compound 17848
                                        tertiary amino compound 10141
                                          tertiary amine 642
                                            doxylamine 2
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