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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fluvoxamine
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Accession:CHEBI:5138 term browser browse the term
Definition:An oxime O-ether that is benzene substituted by a (1E)-N-(2-aminoethoxy)-5-methoxypentanimidoyl group at position 1 and a trifluoromethyl group at position 4. It is a selective serotonin reuptake inhibitor that is used for the treatment of obsessive-compulsive disorder.
Synonyms:exact_synonym: (1E)-5-methoxy-1-[4-(trifluoromethyl)phenyl]pentan-1-one O-(2-aminoethyl)oxime
 related_synonym: 2-{[(E)-{5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene}amino]oxy}ethan-1-amine;   Formula=C15H21F3N2O2;   InChI=1S/C15H21F3N2O2/c1-21-10-3-2-4-14(20-22-11-9-19)12-5-7-13(8-6-12)15(16,17)18/h5-8H,2-4,9-11,19H2,1H3/b20-14+;   InChIKey=CJOFXWAVKWHTFT-XSFVSMFZSA-N;   O-(2-aminoethyl)-N-{(1E)-5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene}hydroxylamine;   SMILES=COCCCC\\C(=N/OCCN)C1=CC=C(C=C1)C(F)(F)F;   fluvoxamina;   fluvoxaminum
 xref: Beilstein:5583954;   CAS:54739-18-3;   Chemspider:4481878;   DrugBank:DB00176;   Drug_Central:1230;   HMDB:HMDB0014322;   KEGG:C07571;   KEGG:D07984
 xref_mesh: MESH:D016666
 xref: MetaCyc:CPD-20520;   PDBeChem:FVX;   PMID:10456487;   PMID:11825104;   PMID:12107854;   PMID:15686112;   PMID:16316311;   PMID:18976545;   PMID:20025739;   PMID:20573265;   PMID:22859721;   PMID:24121440;   PMID:29379174;   PMID:30690950;   PMID:30734885;   PMID:31807102;   PMID:31807753;   PMID:32618683;   PMID:32672818;   PMID:33180097;   PMID:33392622;   PMID:7988100;   PMID:9164424;   Patent:NL7503310;   Patent:US4085225;   Wikipedia:Fluvoxamine


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fluvoxamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Fluvoxamine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Fluvoxamine results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance ISO ABCB1A protein affects the susceptibility to Fluvoxamine CTD PMID:15502009 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Fluvoxamine CTD PMID:15502009 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Fluvoxamine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Avp arginine vasopressin increases expression ISO Fluvoxamine results in increased expression of AVP protein CTD PMID:11195401 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO Fluvoxamine results in increased activity of CASP3 protein
Palmitic Acid promotes the reaction [Fluvoxamine results in increased activity of CASP3 protein]
CTD PMID:22700542 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
ISO Fluvoxamine results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Fluvoxamine results in increased activity of CASP7 protein]
CTD PMID:22700542 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO Fluvoxamine results in decreased activity of CYP19A1 protein CTD PMID:26162595 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
increases response to substance
ISO
EXP
[Fluvoxamine results in decreased activity of CYP1A2 protein] which results in decreased chemical synthesis of 16-O-demethylaconitine metabolite; [Fluvoxamine results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [Fluvoxamine results in decreased activity of CYP1A2 protein] which results in increased chemical synthesis of Aconitine metabolite; CYP1A2 protein binds to and affects the metabolism of Fluvoxamine; Enoxacin inhibits the reaction [CYP1A2 protein affects the metabolism of Fluvoxamine]; Fluvoxamine inhibits the reaction [CYP1A2 protein affects the metabolism of olanzapine]; Fluvoxamine inhibits the reaction [CYP1A2 protein affects the metabolism of Theophylline]; Fluvoxamine inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of Acetaminophen]; Fluvoxamine inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of clozapine N-oxide]; Fluvoxamine inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of norclozapine]; Fluvoxamine inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]
[Fluvoxamine results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Caffeine
CYP1A2 protein results in increased susceptibility to Fluvoxamine
CTD PMID:9029748 PMID:11763009 PMID:15545309 PMID:15845683 PMID:15905806 More... NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO Fluvoxamine inhibits the reaction [CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol] CTD PMID:12584149 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO Fluvoxamine inhibits the reaction [CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol] CTD PMID:12584149 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions EXP [Haloperidol co-treated with Fluvoxamine] affects the expression of GAD1 protein CTD PMID:15967061 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A affects response to substance ISO HTR2A gene SNP affects the susceptibility to Fluvoxamine CTD PMID:12607287 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO
EXP
Fluvoxamine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of ICAM1 mRNA]
Fluvoxamine inhibits the reaction [Carrageenan results in increased expression of ICAM1 mRNA]
CTD PMID:27803785 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
ISO [Terfenadine co-treated with Fluvoxamine] binds to and results in decreased activity of KCNH2 protein; Fluvoxamine binds to and results in decreased activity of KCNH2 protein; Fluvoxamine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Fluvoxamine results in decreased activity of KCNH2 protein
CTD PMID:20071423 PMID:21158687 PMID:24052561 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
EXP
ISO
Fluvoxamine results in increased expression of NOS2 mRNA
Fluvoxamine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]
Fluvoxamine inhibits the reaction [Carrageenan results in increased expression of NOS2 mRNA]
CTD PMID:12429386 PMID:27803785 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Prkcb protein kinase C, beta multiple interactions EXP [Haloperidol co-treated with Fluvoxamine] affects the expression of PRKCB protein CTD PMID:15967061 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO
Fluvoxamine inhibits the reaction [Carrageenan results in increased expression of PTGS2 mRNA]
Fluvoxamine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 mRNA]
CTD PMID:27803785 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 decreases activity
affects response to substance
ISO Fluvoxamine results in decreased activity of SCN5A protein
SCN5A protein affects the susceptibility to Fluvoxamine
CTD PMID:19875396 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP
ISO
Fluvoxamine inhibits the reaction [Carrageenan results in increased expression of VCAM1 mRNA]
Fluvoxamine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of VCAM1 mRNA]
CTD PMID:27803785 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      application 19481
        solvent 16636
          (trifluoromethyl)benzene 380
            fluvoxamine 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      s-block molecular entity 19502
                        hydrogen molecular entity 19498
                          hydrides 18852
                            organic hydride 18353
                              organic fundamental parent 18353
                                hydrocarbon 18066
                                  halohydrocarbon 14049
                                    haloalkane 11706
                                      fluoroalkane 7212
                                        fluoromethanes 6408
                                          tetrafluoromethane 6408
                                            trifluoromethyl group 6408
                                              (trifluoromethyl)benzenes 6408
                                                (trifluoromethyl)benzene 380
                                                  fluvoxamine 20
paths to the root