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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fluvoxamine
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Accession:CHEBI:5138 term browser browse the term
Definition:A 5-methoxyvalerophenone O-(2-aminoethyl)oxime that has formula C15H21F3N2O2.
Synonyms:exact_synonym: (1E)-5-methoxy-1-[4-(trifluoromethyl)phenyl]pentan-1-one O-(2-aminoethyl)oxime
 related_synonym: Formula=C15H21F3N2O2;   InChI=1S/C15H21F3N2O2/c1-21-10-3-2-4-14(20-22-11-9-19)12-5-7-13(8-6-12)15(16,17)18/h5-8H,2-4,9-11,19H2,1H3/b20-14+;   InChIKey=CJOFXWAVKWHTFT-XSFVSMFZSA-N;   SMILES=COCCCC\\C(c1ccc(cc1)C(F)(F)F)=N/OCCN;   fluvoxamina;   fluvoxaminum
 xref: Beilstein:5583954;   CAS:54739-18-3;   DrugBank:DB00176;   Drug_Central:1230;   KEGG:C07571;   KEGG:D07984
 xref_mesh: MESH:D016666
 xref: Patent:NL7503310;   Patent:US4085225;   Wikipedia:Fluvoxamine


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fluvoxamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Fluvoxamine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Fluvoxamine results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance ISO ABCB1A protein affects the susceptibility to Fluvoxamine CTD PMID:15502009 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Fluvoxamine CTD PMID:15502009 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Fluvoxamine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Avp arginine vasopressin increases expression ISO Fluvoxamine results in increased expression of AVP protein CTD PMID:11195401 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO Fluvoxamine results in increased activity of CASP3 protein
Palmitic Acid promotes the reaction [Fluvoxamine results in increased activity of CASP3 protein]
CTD PMID:22700542 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
ISO Fluvoxamine results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Fluvoxamine results in increased activity of CASP7 protein]
CTD PMID:22700542 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO Fluvoxamine results in decreased activity of CYP19A1 protein CTD PMID:26162595 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
increases response to substance
ISO
EXP
[Fluvoxamine results in decreased activity of CYP1A2 protein] which results in decreased chemical synthesis of 16-O-demethylaconitine metabolite; [Fluvoxamine results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [Fluvoxamine results in decreased activity of CYP1A2 protein] which results in increased chemical synthesis of Aconitine metabolite; CYP1A2 protein binds to and affects the metabolism of Fluvoxamine; Enoxacin inhibits the reaction [CYP1A2 protein affects the metabolism of Fluvoxamine]; Fluvoxamine inhibits the reaction [CYP1A2 protein affects the metabolism of olanzapine]; Fluvoxamine inhibits the reaction [CYP1A2 protein affects the metabolism of Theophylline]; Fluvoxamine inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of Acetaminophen]; Fluvoxamine inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of clozapine N-oxide]; Fluvoxamine inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of norclozapine]; Fluvoxamine inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]
[Fluvoxamine results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Caffeine
CYP1A2 protein results in increased susceptibility to Fluvoxamine
CTD PMID:9029748, PMID:11763009, PMID:15545309, PMID:15845683, PMID:15905806, PMID:18809730, PMID:18816299, PMID:21277363, PMID:21915887, PMID:26599973 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO Fluvoxamine inhibits the reaction [CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol] CTD PMID:12584149 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions EXP [Haloperidol co-treated with Fluvoxamine] affects the expression of GAD1 protein CTD PMID:15967061 NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A affects response to substance ISO HTR2A gene SNP affects the susceptibility to Fluvoxamine CTD PMID:12607287 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO
EXP
Fluvoxamine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of ICAM1 mRNA]
Fluvoxamine inhibits the reaction [Carrageenan results in increased expression of ICAM1 mRNA]
CTD PMID:27803785 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
ISO [Terfenadine co-treated with Fluvoxamine] binds to and results in decreased activity of KCNH2 protein; Fluvoxamine binds to and results in decreased activity of KCNH2 protein; Fluvoxamine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Fluvoxamine results in decreased activity of KCNH2 protein
CTD PMID:20071423, PMID:21158687, PMID:24052561 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
EXP
ISO
Fluvoxamine results in increased expression of NOS2 mRNA
Fluvoxamine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]
Fluvoxamine inhibits the reaction [Carrageenan results in increased expression of NOS2 mRNA]
CTD PMID:12429386, PMID:27803785 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Prkcb protein kinase C, beta multiple interactions EXP [Haloperidol co-treated with Fluvoxamine] affects the expression of PRKCB protein CTD PMID:15967061 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO
Fluvoxamine inhibits the reaction [Carrageenan results in increased expression of PTGS2 mRNA]
Fluvoxamine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 mRNA]
CTD PMID:27803785 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 decreases activity
affects response to substance
ISO Fluvoxamine results in decreased activity of SCN5A protein
SCN5A protein affects the susceptibility to Fluvoxamine
CTD PMID:19875396 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP
ISO
Fluvoxamine inhibits the reaction [Carrageenan results in increased expression of VCAM1 mRNA]
Fluvoxamine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of VCAM1 mRNA]
CTD PMID:27803785 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        solvent 16459
          (trifluoromethyl)benzene 373
            fluvoxamine 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            organic hydride 18249
                              organic fundamental parent 18249
                                hydrocarbon 17969
                                  halohydrocarbon 13937
                                    haloalkane 11657
                                      fluoroalkane 7110
                                        fluoromethanes 6330
                                          tetrafluoromethane 6330
                                            trifluoromethyl group 6330
                                              (trifluoromethyl)benzenes 6330
                                                (trifluoromethyl)benzene 373
                                                  fluvoxamine 19
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.