CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: neuromuscular agent
Accession: CHEBI:51372
browse the term
Definition: A drug used for its actions on skeletal muscle.
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Abcb1a
ATP binding cassette subfamily B member 1A
increases activity
ISO
glaucine results in increased activity of ABCB1 protein
CTD
PMID:23273999
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases chemical synthesis increases glucuronidation multiple interactions increases abundance
ISO
CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam CYP3A4 protein results in increased glucuronidation of 1-hydroxymethylmidazolam [[3-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[5-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[6-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[6-methylflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[7-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[alpha-naphthoflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[artemetin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[beta-Naphthoflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[chrysin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[eupatilin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[flavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[galangin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[nobiletin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[sinensetin analog results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[sinensetin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[tangeretin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [CYP3A4 protein results in increased glucuronidation of 1-hydroxymethylmidazolam] which results in increased abundance of 1-hydroxymethylmidazolam glucuronide; [CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased abundance of 1-hydroxymethylmidazolam; [CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased chemical synthesis of 1-hydroxymethylmidazolam; [L 754394 results in decreased activity of CYP3A4 protein] which results in decreased chemical synthesis of 1-hydroxymethylmidazolam; acacetin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Apigenin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; CYP3A4 protein inhibits the reaction [Rifampin results in decreased chemical synthesis of 1-hydroxymethylmidazolam]; diosmetin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; erdafitinib inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; flavanone promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; flavone promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; galangin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased abundance of 1-hydroxymethylmidazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Luteolin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; NADP deficiency inhibits the reaction [erdafitinib inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]]; Rifampin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Rifampin promotes the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Verapamil inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]
CTD
PMID:10997946 PMID:12401345 PMID:12695342 PMID:18191104 PMID:20233841 PMID:21053930 PMID:21915887 PMID:23850985 PMID:26958860 PMID:27485346 PMID:30087611 PMID:31756459 PMID:34189909 More...
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
increases chemical synthesis multiple interactions
ISO
CYP3A5 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam [CYP3A5 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; erdafitinib inhibits the reaction [[CYP3A5 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]
CTD
PMID:18191104 PMID:26958860 PMID:34189909
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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Tspo
translocator protein
affects binding
EXP
1-hydroxymethylmidazolam binds to TSPO protein; 1-hydroxymethylmidazolam metabolite binds to TSPO protein
CTD
PMID:7603229
NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions
ISO
[CYP3A4 protein results in increased glucuronidation of 1-hydroxymethylmidazolam] which results in increased abundance of 1-hydroxymethylmidazolam glucuronide
CTD
PMID:27485346
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
affects chemical synthesis
ISO
CYP3A4 protein affects the chemical synthesis of 3-hydroxyquinidine
CTD
PMID:15896247
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases chemical synthesis multiple interactions
ISO
CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam [CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased abundance of 4-hydroxymidazolam; [CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam; acacetin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; Apigenin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; CYP3A4 protein inhibits the reaction [Rifampin results in decreased chemical synthesis of 4-hydroxymidazolam]; diosmetin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam]; flavanone inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; flavone inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; galangin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam]; Luteolin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam]; Rifampin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam]
CTD
PMID:12695342 PMID:18191104 PMID:21053930 PMID:27485346
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
increases chemical synthesis multiple interactions
ISO
CYP3A5 protein results in increased chemical synthesis of 4-hydroxymidazolam diosmetin inhibits the reaction [CYP3A5 protein results in increased chemical synthesis of 4-hydroxymidazolam]; Luteolin inhibits the reaction [CYP3A5 protein results in increased chemical synthesis of 4-hydroxymidazolam]
CTD
PMID:18191104
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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Arhgef17
Rho guanine nucleotide exchange factor 17
multiple interactions
ISO
[8-bromocyclic GMP co-treated with PRKG1 protein co-treated with ARHGEF17 protein] results in increased activity of SRF protein
CTD
PMID:23195829
NCBI chr 1:155,230,607...155,290,163
Ensembl chr 1:155,233,168...155,290,498
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Casp3
caspase 3
multiple interactions
ISO
8-bromocyclic GMP inhibits the reaction [TNF protein results in increased activity of CASP3 protein]; KT 5823 inhibits the reaction [8-bromocyclic GMP inhibits the reaction [TNF protein results in increased activity of CASP3 protein]]
CTD
PMID:9388267
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cox4i1
cytochrome c oxidase subunit 4i1
increases expression multiple interactions
ISO
8-bromocyclic GMP results in increased expression of COX4I1 protein tin protoporphyrin IX inhibits the reaction [8-bromocyclic GMP results in increased expression of COX4I1 protein]
CTD
PMID:24041027
NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921
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Dusp10
dual specificity phosphatase 10
increases expression
ISO
8-bromocyclic GMP results in increased expression of DUSP10 mRNA; 8-bromocyclic GMP results in increased expression of DUSP10 protein
CTD
PMID:29165873
NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716
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Edn1
endothelin 1
multiple interactions
EXP ISO
8-bromocyclic GMP inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein] 8-bromocyclic GMP inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]; 8-bromocyclic GMP inhibits the reaction [cobaltous chloride results in increased expression of EDN1 protein]
CTD
PMID:16023617 PMID:29165873
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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Edn3
endothelin 3
multiple interactions
EXP
8-bromocyclic GMP inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein]
CTD
PMID:16023617
NCBI chr 3:163,562,307...163,586,636
Ensembl chr 3:163,562,520...163,585,093
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Ednrb
endothelin receptor type B
multiple interactions
EXP
8-bromocyclic GMP inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein]; 8-bromocyclic GMP inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein]
CTD
PMID:16023617
NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
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Hif1a
hypoxia inducible factor 1 subunit alpha
multiple interactions
ISO
8-bromocyclic GMP inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]; 8-bromocyclic GMP inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]
CTD
PMID:29165873
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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Hmox1
heme oxygenase 1
increases expression
ISO
8-bromocyclic GMP results in increased expression of HMOX1 mRNA; 8-bromocyclic GMP results in increased expression of HMOX1 protein
CTD
PMID:24041027
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Il1b
interleukin 1 beta
multiple interactions
ISO
8-bromocyclic GMP promotes the reaction [IL1B protein results in increased abundance of Nitrites]; Dipyridamole promotes the reaction [8-bromocyclic GMP promotes the reaction [IL1B protein results in increased abundance of Nitrites]]
CTD
PMID:8904084
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il4
interleukin 4
increases expression multiple interactions
ISO
8-bromocyclic GMP results in increased expression of IL4 mRNA Cyclosporine inhibits the reaction [8-bromocyclic GMP results in increased expression of IL4 mRNA]
CTD
PMID:16533816
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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Mapk1
mitogen activated protein kinase 1
decreases phosphorylation
ISO
8-bromocyclic GMP results in decreased phosphorylation of MAPK1 protein
CTD
PMID:17828804
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
decreases phosphorylation
ISO
8-bromocyclic GMP results in decreased phosphorylation of MAPK3 protein
CTD
PMID:17828804
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Myc
MYC proto-oncogene, bHLH transcription factor
decreases phosphorylation
ISO
8-bromocyclic GMP results in decreased phosphorylation of MYC protein
CTD
PMID:17828804
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Ndufb8
NADH:ubiquinone oxidoreductase subunit B8
increases expression multiple interactions
ISO
8-bromocyclic GMP results in increased expression of NDUFB8 protein tin protoporphyrin IX inhibits the reaction [8-bromocyclic GMP results in increased expression of NDUFB8 protein]
CTD
PMID:24041027
NCBI chr 1:243,408,656...243,413,715
Ensembl chr 1:243,408,619...243,413,817
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Nfatc1
nuclear factor of activated T-cells 1
affects localization
ISO
8-bromocyclic GMP affects the localization of NFATC1 protein
CTD
PMID:16533816
NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028
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Nrf1
nuclear respiratory factor 1
increases expression multiple interactions
ISO
8-bromocyclic GMP results in increased expression of NRF1 mRNA tin protoporphyrin IX inhibits the reaction [8-bromocyclic GMP results in increased expression of NRF1 mRNA]
CTD
PMID:24041027
NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328
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Pde5a
phosphodiesterase 5A
multiple interactions
ISO
[1-Methyl-3-isobutylxanthine co-treated with 8-bromocyclic GMP] results in increased expression of PDE5A protein; [1-Methyl-3-isobutylxanthine co-treated with 8-bromocyclic GMP] results in increased expression of PDE5A protein modified form
CTD
PMID:20613715
NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
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Ppargc1a
PPARG coactivator 1 alpha
increases expression multiple interactions
ISO
8-bromocyclic GMP results in increased expression of PPARGC1A mRNA tin protoporphyrin IX inhibits the reaction [8-bromocyclic GMP results in increased expression of PPARGC1A mRNA]
CTD
PMID:24041027
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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Prkg1
protein kinase cGMP-dependent 1
increases expression multiple interactions
EXP ISO
8-bromocyclic GMP results in increased expression of PRKG1 protein [8-bromocyclic GMP co-treated with PRKG1 protein co-treated with ARHGEF17 protein] results in increased activity of SRF protein
CTD
PMID:12620371 PMID:23195829
NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080
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Scnn1b
sodium channel epithelial 1 subunit beta
multiple interactions
ISO
[1-Methyl-3-isobutylxanthine co-treated with 8-bromocyclic GMP] results in increased expression of SCNN1B protein
CTD
PMID:20613715
NCBI chr 1:176,430,063...176,484,451
Ensembl chr 1:176,430,103...176,484,451
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Sod2
superoxide dismutase 2
increases expression
EXP
8-bromocyclic GMP results in increased expression of SOD2 mRNA; 8-bromocyclic GMP results in increased expression of SOD2 protein
CTD
PMID:14996425
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Spp1
secreted phosphoprotein 1
multiple interactions
EXP
8-bromocyclic GMP inhibits the reaction [Glucose results in increased secretion of SPP1 protein]; Dinitrochlorobenzene inhibits the reaction [8-bromocyclic GMP inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; KT 5823 inhibits the reaction [8-bromocyclic GMP inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [8-bromocyclic GMP inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]
CTD
PMID:20453393
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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Srf
serum response factor
multiple interactions
ISO
[8-bromocyclic GMP co-treated with PRKG1 protein co-treated with ARHGEF17 protein] results in increased activity of SRF protein
CTD
PMID:23195829
NCBI chr 9:14,426,453...14,435,734
Ensembl chr 9:14,426,472...14,435,733
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Tfam
transcription factor A, mitochondrial
increases expression multiple interactions
ISO
8-bromocyclic GMP results in increased expression of TFAM mRNA tin protoporphyrin IX inhibits the reaction [8-bromocyclic GMP results in increased expression of TFAM mRNA]
CTD
PMID:24041027
NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
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Th
tyrosine hydroxylase
multiple interactions
EXP
8-bromocyclic GMP inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein]; 8-bromocyclic GMP inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein]
CTD
PMID:16023617
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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Tnf
tumor necrosis factor
multiple interactions
ISO
8-bromocyclic GMP inhibits the reaction [TNF protein results in increased activity of CASP3 protein]; KT 5823 inhibits the reaction [8-bromocyclic GMP inhibits the reaction [TNF protein results in increased activity of CASP3 protein]]
CTD
PMID:9388267
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tp53
tumor protein p53
increases expression
EXP
8-bromocyclic GMP results in increased expression of TP53 protein
CTD
PMID:9888876
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Trpc6
transient receptor potential cation channel, subfamily C, member 6
multiple interactions increases phosphorylation
EXP ISO
8-bromocyclic GMP inhibits the reaction [1-oleoyl-2-acetylglycerol results in increased activity of TRPC6 protein] 8-bromocyclic GMP results in increased phosphorylation of TRPC6 protein KT 5823 inhibits the reaction [8-bromocyclic GMP results in increased phosphorylation of TRPC6 protein]
CTD
PMID:20177073
NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092
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Txn1
thioredoxin 1
multiple interactions
EXP
8-bromocyclic GMP inhibits the reaction [Glucose results in decreased expression of TXN1 protein]
CTD
PMID:20453393
NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
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Uqcrc1
ubiquinol-cytochrome c reductase core protein 1
multiple interactions increases expression
ISO
tin protoporphyrin IX inhibits the reaction [8-bromocyclic GMP results in increased expression of UQCRC1 protein]
CTD
PMID:24041027
NCBI chr 8:109,589,735...109,601,481
Ensembl chr 8:109,589,706...109,601,480
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Vcam1
vascular cell adhesion molecule 1
decreases expression
ISO
8-bromocyclic GMP results in decreased expression of VCAM1 protein
CTD
PMID:17828804
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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Vegfa
vascular endothelial growth factor A
decreases expression
ISO
8-bromocyclic GMP results in decreased expression of VEGFA protein
CTD
PMID:17828804
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Chrm4
cholinergic receptor, muscarinic 4
multiple interactions affects binding
ISO
WIN 62577 inhibits the reaction [Alcuronium binds to CHRM4 protein]
CTD
PMID:16709648
NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159
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Chrna4
cholinergic receptor nicotinic alpha 4 subunit
multiple interactions
ISO
Alcuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Alcuronium results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
CTD
PMID:14645658
NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
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Chrnb2
cholinergic receptor nicotinic beta 2 subunit
multiple interactions
ISO
Alcuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Alcuronium results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
CTD
PMID:14645658
NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
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Capn1
calpain 1
multiple interactions
ISO
[Caffeine co-treated with Alprazolam] promotes the reaction [Calcium results in increased activity of CAPN1 protein]
CTD
PMID:19490937
NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
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Casp3
caspase 3
multiple interactions
ISO
[Caffeine co-treated with Alprazolam] results in increased cleavage of CASP3 protein
CTD
PMID:19490937
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Ctsb
cathepsin B
multiple interactions
ISO
[Caffeine co-treated with Alprazolam] results in increased secretion of CTSB protein
CTD
PMID:19490937
NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions affects metabolic processing
ISO
CYP3A4 protein binds to and affects the metabolism of Alprazolam CYP3A4 protein affects the metabolism of Alprazolam
CTD
PMID:12196913 PMID:15856409 PMID:16042670
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a23-3a1
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
affects metabolic processing
EXP
CYP3A23-3A1 protein affects the metabolism of Alprazolam
CTD
PMID:12196913
NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
increases hydroxylation
ISO
CYP3A5 protein results in increased hydroxylation of Alprazolam
CTD
PMID:15903124
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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Il2
interleukin 2
decreases expression
ISO
Alprazolam results in decreased expression of IL2 protein
CTD
PMID:1624223
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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Lhb
luteinizing hormone subunit beta
increases secretion
ISO
Alprazolam results in increased secretion of LHB protein
CTD
PMID:7883836
NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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Parp1
poly (ADP-ribose) polymerase 1
multiple interactions
ISO
[Caffeine co-treated with Alprazolam] results in increased activity of PARP1 protein
CTD
PMID:19490937
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Plcb1
phospholipase C beta 1
decreases expression
EXP
Alprazolam results in decreased expression of PLCB1 mRNA; Alprazolam results in decreased expression of PLCB1 protein
CTD
PMID:12527476
NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869
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Ppia
peptidylprolyl isomerase A
increases hydroxylation
ISO
PPIA protein results in increased hydroxylation of Alprazolam
CTD
PMID:15806426
NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Alprazolam inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Trh
thyrotropin releasing hormone
multiple interactions
EXP
Alprazolam inhibits the reaction [TRH protein modified form binds to TRHR protein]
CTD
PMID:2845442
NCBI chr 4:124,742,111...124,777,094
Ensembl chr 4:124,742,111...124,744,637
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Trhr
thyrotropin releasing hormone receptor
multiple interactions
EXP
Alprazolam inhibits the reaction [TRH protein modified form binds to TRHR protein]
CTD
PMID:2845442
NCBI chr 7:75,348,672...75,393,310
Ensembl chr 7:75,348,672...75,393,309
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Htr1a
5-hydroxytryptamine receptor 1A
affects binding
EXP
alverine binds to HTR1A protein
CTD
PMID:11697552
NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442
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Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
alverine results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Aldh18a1
aldehyde dehydrogenase 18 family, member A1
increases expression
ISO
Aminophylline results in increased expression of ALDH18A1 mRNA
CTD
PMID:29901742
NCBI chr 1:239,375,657...239,407,956
Ensembl chr 1:239,375,669...239,407,890
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Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
[Aminophylline co-treated with Gemcitabine] results in decreased expression of BCL2 protein
CTD
PMID:15645133
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Cat
catalase
multiple interactions
ISO
[Aminophylline co-treated with Photosensitizing Agents] promotes the reaction [Benzo(a)pyrene results in increased expression of CAT protein]
CTD
PMID:30776357
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Gcg
glucagon
increases secretion
EXP
Aminophylline results in increased secretion of GCG protein
CTD
PMID:1248788
NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929
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Hrh1
histamine receptor H 1
multiple interactions
ISO
[Astemizole binds to and results in decreased activity of HRH1 protein] which affects the susceptibility to Aminophylline
CTD
PMID:16129921
NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455
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Ins1
insulin 1
increases secretion
EXP
Aminophylline results in increased secretion of INS1 protein
CTD
PMID:1248788
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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Chrna3
cholinergic receptor nicotinic alpha 3 subunit
multiple interactions
ISO
Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]
CTD
PMID:16931985
NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165
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Chrna4
cholinergic receptor nicotinic alpha 4 subunit
multiple interactions
ISO
Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
CTD
PMID:16931985
NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
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Chrna7
cholinergic receptor nicotinic alpha 7 subunit
multiple interactions
ISO
Atracurium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]
CTD
PMID:16931985
NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240
G
Chrnb2
cholinergic receptor nicotinic beta 2 subunit
multiple interactions
ISO
Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
CTD
PMID:16931985
NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
G
Chrnb4
cholinergic receptor nicotinic beta 4 subunit
multiple interactions
ISO
Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]
CTD
PMID:16931985
NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027
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Hexb
hexosaminidase subunit beta
increases secretion
ISO
Atracurium results in increased secretion of HEXB protein
CTD
PMID:19758318
NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223
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Abcc4
ATP binding cassette subfamily C member 4
increases transport
ISO
ABCC4 protein results in increased transport of Baclofen
CTD
PMID:17939016
NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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Cftr
CF transmembrane conductance regulator
multiple interactions
ISO
Baclofen promotes the reaction [Isoproterenol results in increased activity of CFTR protein]
CTD
PMID:15151902
NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
G
Creb1
cAMP responsive element binding protein 1
multiple interactions
ISO
Baclofen inhibits the reaction [Amphetamine affects the phosphorylation of CREB1 protein]
CTD
PMID:16983645
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
G
Drd3
dopamine receptor D3
decreases expression
EXP
Baclofen results in decreased expression of DRD3 mRNA
CTD
PMID:7878047
NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO EXP
Baclofen inhibits the reaction [Cocaine results in increased expression of FOS protein]
CTD
PMID:16710312 PMID:16930414
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
G
Fshb
follicle stimulating hormone subunit beta
decreases expression multiple interactions
EXP
Baclofen results in decreased expression of FSHB protein Baclofen inhibits the reaction [Diethylhexyl Phthalate results in increased expression of FSHB protein]
CTD
PMID:29774754
NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
G
Gabbr1
gamma-aminobutyric acid type B receptor subunit 1
increases response to substance
ISO
GABBR1 results in increased susceptibility to Baclofen
CTD
PMID:16990508 PMID:20138995
NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994
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Gabbr2
gamma-aminobutyric acid type B receptor subunit 2
increases response to substance
ISO
GABBR2 results in increased susceptibility to Baclofen
CTD
PMID:20138995
NCBI chr 5:60,947,517...61,288,104
Ensembl chr 5:60,947,526...61,288,104
G
Kcnj6
potassium inwardly-rectifying channel, subfamily J, member 6
increases response to substance
ISO
KCNJ6 results in increased susceptibility to Baclofen
CTD
PMID:12836919
NCBI chr11:34,061,702...34,308,758
Ensembl chr11:34,061,708...34,308,758
G
Lhb
luteinizing hormone subunit beta
decreases expression multiple interactions
EXP
Baclofen results in decreased expression of LHB protein Baclofen inhibits the reaction [Diethylhexyl Phthalate results in increased expression of LHB protein]
CTD
PMID:29774754
NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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Maob
monoamine oxidase B
multiple interactions
ISO
Baclofen affects the reaction [MAOB gene mutant form results in decreased susceptibility to Amphetamine]
CTD
PMID:16983645
NCBI chr X:5,907,327...6,010,996
Ensembl chr X:5,907,266...6,011,003
G
Mapk1
mitogen activated protein kinase 1
increases phosphorylation multiple interactions
EXP
Baclofen results in increased phosphorylation of MAPK1 protein CGP 56999A inhibits the reaction [Baclofen results in increased phosphorylation of MAPK1 protein]
CTD
PMID:24668805
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
multiple interactions increases phosphorylation
EXP
CGP 56999A inhibits the reaction [Baclofen results in increased phosphorylation of MAPK3 protein]
CTD
PMID:24668805
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Pdyn
prodynorphin
multiple interactions
EXP
Baclofen inhibits the reaction [Amphetamine results in increased expression of PDYN mRNA]
CTD
PMID:15033416 PMID:15592348
NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334
G
Penk
proenkephalin
multiple interactions
EXP
Baclofen inhibits the reaction [Amphetamine results in increased expression of PENK mRNA]
CTD
PMID:15033416 PMID:15592348
NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
G
Ryr1
ryanodine receptor 1
multiple interactions
ISO
Baclofen inhibits the reaction [A 68930 results in increased expression of RYR1 protein]; Baclofen inhibits the reaction [SK&F 82958 results in increased expression of RYR1 protein]
CTD
PMID:22504960
NCBI chr 1:84,292,578...84,423,824
Ensembl chr 1:84,292,578...84,423,812
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Ryr2
ryanodine receptor 2
multiple interactions
ISO
Baclofen inhibits the reaction [A 68930 results in increased expression of RYR2 protein]; Baclofen inhibits the reaction [SK&F 82958 results in increased expression of RYR2 protein]
CTD
PMID:22504960
NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142
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Scg2
secretogranin II
multiple interactions
EXP
Baclofen inhibits the reaction [Amphetamine results in increased expression of SCG2 mRNA]
CTD
PMID:15033416 PMID:15592348
NCBI chr 9:80,803,074...80,808,646
Ensembl chr 9:80,803,075...80,821,097
G
Tac1
tachykinin, precursor 1
multiple interactions
EXP
Baclofen inhibits the reaction [Amphetamine results in increased expression of TAC1 mRNA]
CTD
PMID:15033416
NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
G
Tnf
tumor necrosis factor
decreases secretion
ISO
Baclofen results in decreased secretion of TNF protein
CTD
PMID:20201957
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Butylscopolammonium Bromide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
G
Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
multiple interactions
ISO
[CYP2C19 gene polymorphism affects the metabolism of Carisoprodol] which affects the chemical synthesis of Meprobamate; [CYP2C19 protein results in increased metabolism of Carisoprodol] which results in increased chemical synthesis of Meprobamate
CTD
PMID:12835613 PMID:22527345
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
G
Gabra1
gamma-aminobutyric acid type A receptor subunit alpha 1
multiple interactions
ISO
Bemegride inhibits the reaction [Carisoprodol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Carisoprodol binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]
CTD
PMID:19244096
NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
G
Gabrb2
gamma-aminobutyric acid type A receptor subunit beta 2
multiple interactions
ISO
Bemegride inhibits the reaction [Carisoprodol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Carisoprodol binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]
CTD
PMID:19244096
NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251
G
Gabrg2
gamma-aminobutyric acid type A receptor subunit gamma 2
multiple interactions
ISO
Bemegride inhibits the reaction [Carisoprodol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Carisoprodol binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]
CTD
PMID:19244096
NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346
G
Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
chlorphenesin carbamate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Cyb5a
cytochrome b5 type A
multiple interactions
ISO
CYB5A protein promotes the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]
CTD
PMID:15728263
NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535 Ensembl chr18:78,202,342...78,258,535
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
affects metabolic processing
EXP
CYP1A1 protein affects the metabolism of Chlorzoxazone
CTD
PMID:15231049 PMID:15879494
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
affects metabolic processing increases hydroxylation
ISO EXP
CYP1A2 protein affects the metabolism of Chlorzoxazone CYP1A2 protein results in increased hydroxylation of Chlorzoxazone
CTD
PMID:11911841 PMID:14586387 PMID:15879494
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
G
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases activity
ISO
Chlorzoxazone results in decreased activity of CYP1B1 protein
CTD
PMID:33814510
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
G
Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
affects metabolic processing
EXP
CYP2B1 protein affects the metabolism of Chlorzoxazone
CTD
PMID:15879494
NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
affects metabolic processing
EXP
CYP2C11 protein affects the metabolism of Chlorzoxazone
CTD
PMID:15879494
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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Cyp2c13
cytochrome P450, family 2, subfamily c, polypeptide 13
affects metabolic processing
EXP
CYP2C13 protein affects the metabolism of Chlorzoxazone
CTD
PMID:15879494
NCBI chr 1:238,786,764...238,867,195
Ensembl chr 1:238,786,765...238,867,191
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
affects metabolic processing
EXP
CYP2C6V1 protein affects the metabolism of Chlorzoxazone
CTD
PMID:15879494
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
affects hydroxylation increases metabolic processing increases hydroxylation multiple interactions affects metabolic processing increases oxidation
ISO EXP
CYP2E1 protein affects the hydroxylation of Chlorzoxazone CYP2E1 protein results in increased metabolism of Chlorzoxazone CYP2E1 protein results in increased hydroxylation of Chlorzoxazone [CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased abundance of 6-hydroxychlorzoxazone; [CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone; Resveratrol inhibits the reaction [CYP2E1 protein results in increased metabolism of Chlorzoxazone] CYP2E1 mRNA results in increased metabolism of Chlorzoxazone; CYP2E1 protein results in increased metabolism of Chlorzoxazone CYP2E1 protein affects the metabolism of Chlorzoxazone [CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone; Imidazoles inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; Isoquinolines inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; Pyridines inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; Quinolines inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone] CYP2E1 protein results in increased oxidation of Chlorzoxazone [5-bromotryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [5-chlorotryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [5-fluoro-alpha-methyltryptamine results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [5-fluorotryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [5-methyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [7-methyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [Chlormethiazole results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [Chlorzoxazone results in decreased activity of CYP2E1 protein] which results in decreased degradation of vanoxerine; [CYP2E1 mRNA results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone; [CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone; [indopan analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [indopan results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [Methoxydimethyltryptamines analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [N,N-diisopropyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [Tryptamines analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; Carbaryl inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; chlorfluazuron inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; Chlorpyrifos inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; CYB5A protein promotes the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; cypermethrin inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; Disulfiram inhibits the reaction [[CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone]; Disulfiram inhibits the reaction [CYP2E1 protein results in increased metabolism of Chlorzoxazone]; Fenitrothion inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; fenvalerate inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; Fomepizole inhibits the reaction [CYP2E1 protein results in increased metabolism of Chlorzoxazone]; isoproturon inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; Malathion inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; perfluorooctane sulfonic acid inhibits the reaction [CYP2E1 protein results in increased oxidation of Chlorzoxazone]; phenthoate inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; profenofos inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]
CTD
PMID:7747284 PMID:8558417 PMID:8858968 PMID:9817075 PMID:9825833 PMID:10207612 PMID:10463382 PMID:11502731 PMID:11911841 PMID:12401345 PMID:12433797 PMID:12464242 PMID:12690492 PMID:12818727 PMID:14586387 PMID:15155557 PMID:15205388 PMID:15231049 PMID:15255802 PMID:15327588 PMID:15370959 PMID:15576447 PMID:15618748 PMID:15626586 PMID:15728263 PMID:15802389 PMID:15879494 PMID:16124035 PMID:17565714 PMID:21600194 PMID:21915887 PMID:21964418 PMID:22634058 PMID:23669205 PMID:25956474 PMID:26599973 PMID:26739624 PMID:28438436 PMID:28762043 PMID:29555536 PMID:30503582 PMID:31501917 More...
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
affects metabolic processing
EXP
CYP3A2 protein affects the metabolism of Chlorzoxazone
CTD
PMID:15879494
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
G
Cyp3a23-3a1
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
increases hydroxylation affects metabolic processing
EXP
CYP3A23-3A1 protein results in increased hydroxylation of Chlorzoxazone CYP3A23-3A1 protein affects the metabolism of Chlorzoxazone
CTD
PMID:11911841 PMID:15879494
NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
affects metabolic processing
EXP
CYP3A9 protein affects the metabolism of Chlorzoxazone
CTD
PMID:15879494
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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Ins2
insulin 2
multiple interactions
ISO
INS protein inhibits the reaction [stearic acid results in increased hydroxylation of Chlorzoxazone]
CTD
PMID:26739624
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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Kcnn4
potassium calcium-activated channel subfamily N member 4
increases activity
ISO
Chlorzoxazone results in increased activity of KCNN4 protein
CTD
PMID:14985237
NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340
G
Nat2
N-acetyltransferase 2
affects metabolic processing
ISO
NAT2 protein affects the metabolism of Chlorzoxazone
CTD
PMID:14586387
NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
G
Xdh
xanthine dehydrogenase
affects metabolic processing
ISO
XDH protein affects the metabolism of Chlorzoxazone
CTD
PMID:14586387
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
G
Cdh1
cadherin 1
multiple interactions increases expression
ISO
CXCR4 protein inhibits the reaction [cisatracurium results in increased expression of CDH1 protein]; TGFB1 protein inhibits the reaction [cisatracurium results in increased expression of CDH1 protein]
CTD
PMID:33617803
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
G
Cdh2
cadherin 2
decreases expression multiple interactions
ISO
cisatracurium results in decreased expression of CDH2 protein CXCR4 protein inhibits the reaction [cisatracurium results in decreased expression of CDH2 protein]; TGFB1 protein inhibits the reaction [cisatracurium results in decreased expression of CDH2 protein]
CTD
PMID:33617803
NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
G
Chrna3
cholinergic receptor nicotinic alpha 3 subunit
multiple interactions
ISO
cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]
CTD
PMID:16931985
NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165
G
Chrna4
cholinergic receptor nicotinic alpha 4 subunit
multiple interactions
ISO
cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
CTD
PMID:16931985
NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
G
Chrna7
cholinergic receptor nicotinic alpha 7 subunit
multiple interactions
ISO
cisatracurium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]
CTD
PMID:16931985
NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240
G
Chrnb2
cholinergic receptor nicotinic beta 2 subunit
multiple interactions
ISO
cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
CTD
PMID:16931985
NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
G
Chrnb4
cholinergic receptor nicotinic beta 4 subunit
multiple interactions
ISO
cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]
CTD
PMID:16931985
NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027
G
Cxcr4
C-X-C motif chemokine receptor 4
decreases expression decreases expression multiple interactions
ISO
cisatracurium results in decreased expression of CXCR4 mRNA; cisatracurium results in decreased expression of CXCR4 protein cisatracurium decreases expression of CXCR4 mRNA and protein in colonic epithelium CXCR4 protein inhibits the reaction [cisatracurium results in decreased expression of CDH2 protein]; CXCR4 protein inhibits the reaction [cisatracurium results in decreased expression of VIM protein]; CXCR4 protein inhibits the reaction [cisatracurium results in increased expression of CDH1 protein]; TGFB1 protein inhibits the reaction [cisatracurium results in decreased expression of CXCR4 protein]
CTD RGD
PMID:33617803 PMID:33617803
RGD:151893498
NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
G
Tgfb1
transforming growth factor, beta 1
multiple interactions decreases expression
ISO
TGFB1 protein inhibits the reaction [cisatracurium results in decreased expression of CDH2 protein]; TGFB1 protein inhibits the reaction [cisatracurium results in decreased expression of CXCR4 protein]; TGFB1 protein inhibits the reaction [cisatracurium results in decreased expression of TGFBR1 protein]; TGFB1 protein inhibits the reaction [cisatracurium results in decreased expression of VIM protein]; TGFB1 protein inhibits the reaction [cisatracurium results in increased expression of CDH1 protein] cisatracurium results in decreased expression of TGFB1 protein
CTD
PMID:33617803
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
G
Tgfbr1
transforming growth factor, beta receptor 1
decreases expression multiple interactions
ISO
cisatracurium results in decreased expression of TGFBR1 protein TGFB1 protein inhibits the reaction [cisatracurium results in decreased expression of TGFBR1 protein]
CTD
PMID:33617803
NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
G
Vim
vimentin
decreases expression multiple interactions
ISO
cisatracurium results in decreased expression of VIM protein CXCR4 protein inhibits the reaction [cisatracurium results in decreased expression of VIM protein]; TGFB1 protein inhibits the reaction [cisatracurium results in decreased expression of VIM protein]
CTD
PMID:33617803
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
G
Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
clidinium inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
G
Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
cyclobenzaprine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
G
Abcg2
ATP binding cassette subfamily G member 2
affects transport
ISO
ABCG2 protein affects the transport of Dantrolene
CTD
PMID:18322075
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
G
Ace2
angiotensin converting enzyme 2
increases expression
ISO
Dantrolene results in increased expression of ACE2 mRNA
CTD
PMID:32808185
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
G
Atf4
activating transcription factor 4
decreases expression multiple interactions
EXP ISO
Dantrolene results in decreased expression of ATF4 protein Dantrolene affects the reaction [perfluorooctanoic acid results in increased expression of ATF4 protein]; Dantrolene inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; Dantrolene promotes the reaction [Thapsigargin results in increased expression of ATF4 mRNA]
CTD
PMID:15921666 PMID:32578922
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
G
Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
Dantrolene inhibits the reaction [Halothane results in increased expression of BAX mRNA]
CTD
PMID:32795494
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
G
Bcl2
BCL2, apoptosis regulator
increases expression
EXP
Dantrolene results in increased expression of BCL2 protein
CTD
PMID:10854250
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Bcl2l11
Bcl2-like 11
multiple interactions
ISO
Dantrolene inhibits the reaction [Halothane results in increased expression of BCL2L11 mRNA]
CTD
PMID:32795494
NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
G
Bdnf
brain-derived neurotrophic factor
multiple interactions
ISO
Dantrolene inhibits the reaction [Oxygen deficiency results in increased secretion of BDNF protein]
CTD
PMID:16553631
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
G
Capn1
calpain 1
decreases expression
EXP
Dantrolene results in decreased expression of CAPN1 mRNA; Dantrolene results in decreased expression of CAPN1 protein
CTD
PMID:11236903
NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
G
Capn2
calpain 2
decreases expression
EXP
Dantrolene results in decreased expression of CAPN2 mRNA; Dantrolene results in decreased expression of CAPN2 protein
CTD
PMID:11236903
NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
G
Capn3
calpain 3
decreases expression
EXP
Dantrolene results in decreased expression of CAPN3 mRNA; Dantrolene results in decreased expression of CAPN3 protein
CTD
PMID:11236903
NCBI chr 3:107,407,518...107,457,858
Ensembl chr 3:107,407,850...107,457,858
G
Casp3
caspase 3
multiple interactions
EXP ISO
Dantrolene inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein] Dantrolene inhibits the reaction [Indomethacin results in increased activity of CASP3 protein]
CTD
PMID:17079870 PMID:23022152
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Casp9
caspase 9
multiple interactions
ISO
Dantrolene inhibits the reaction [Indomethacin results in increased activity of CASP9 protein]
CTD
PMID:23022152
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
G
Ccl2
C-C motif chemokine ligand 2
decreases expression
EXP
Dantrolene results in decreased expression of CCL2 mRNA
CTD
PMID:25051504
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
G
Ccl5
C-C motif chemokine ligand 5
affects expression
EXP
Dantrolene affects the expression of CCL5 protein
CTD
PMID:25051504
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
G
Cxcl2
C-X-C motif chemokine ligand 2
multiple interactions
ISO
Dantrolene inhibits the reaction [Halothane results in increased expression of CXCL2 mRNA]
CTD
PMID:32795494
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions
ISO EXP
Dantrolene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
CTD
PMID:18493746
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions
ISO
Dantrolene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
CTD
PMID:18493746
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
G
Ddit3
DNA-damage inducible transcript 3
decreases phosphorylation multiple interactions
EXP ISO
Dantrolene results in decreased phosphorylation of DDIT3 protein Dantrolene inhibits the reaction [Halothane results in increased expression of DDIT3 mRNA]; Dantrolene promotes the reaction [perfluorooctanoic acid results in increased expression of DDIT3 mRNA]; Dantrolene promotes the reaction [perfluorooctanoic acid results in increased expression of DDIT3 protein]
CTD
PMID:15921666 PMID:32578922 PMID:32795494
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
G
Edn1
endothelin 1
decreases activity
EXP
Dantrolene results in decreased activity of EDN1 protein
CTD
PMID:12628492
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
G
Eif2ak3
eukaryotic translation initiation factor 2 alpha kinase 3
decreases phosphorylation
EXP
Dantrolene results in decreased phosphorylation of EIF2AK3 protein
CTD
PMID:15921666
NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
G
Eif2s1
eukaryotic translation initiation factor 2 subunit alpha
decreases phosphorylation multiple interactions
EXP ISO
Dantrolene results in decreased phosphorylation of EIF2S1 protein Dantrolene inhibits the reaction [tributyltin results in increased phosphorylation of EIF2S1 protein]
CTD
PMID:15921666 PMID:23743301
NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
G
Fkbp1a
FKBP prolyl isomerase 1A
multiple interactions
ISO
Dantrolene inhibits the reaction [Halothane results in increased expression of FKBP1A mRNA]
CTD
PMID:32795494
NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743
G
Fkbp1b
FKBP prolyl isomerase 1B
multiple interactions
ISO
Dantrolene inhibits the reaction [Halothane results in increased expression of FKBP1B mRNA]
CTD
PMID:32795494
NCBI chr 6:27,832,128...27,850,600
Ensembl chr 6:27,838,802...27,848,653
G
Gfap
glial fibrillary acidic protein
multiple interactions
EXP
Dantrolene inhibits the reaction [diphenylditelluride results in decreased phosphorylation of GFAP protein]; Dantrolene inhibits the reaction [diphenylditelluride results in increased phosphorylation of GFAP protein]
CTD
PMID:21863293 PMID:21879721
NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
G
Gpt
glutamic--pyruvic transaminase
multiple interactions
ISO
Dantrolene inhibits the reaction [Halothane results in increased expression of GPT protein]
CTD
PMID:32795494
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
G
Hmox1
heme oxygenase 1
multiple interactions
ISO
Dantrolene inhibits the reaction [Halothane results in increased expression of HMOX1 mRNA]
CTD
PMID:32795494
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
G
Homer1
homer scaffold protein 1
multiple interactions
ISO
Dantrolene inhibits the reaction [Halothane results in increased expression of HOMER1 mRNA]
CTD
PMID:32795494
NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785
G
Hspa5
heat shock protein family A (Hsp70) member 5
multiple interactions
ISO
Dantrolene inhibits the reaction [tributyltin results in increased expression of HSPA5 protein]
CTD
PMID:23743301
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
G
Ifng
interferon gamma
multiple interactions
ISO
Dantrolene inhibits the reaction [taurolithocholic acid 3-sulfate results in increased expression of IFNG mRNA]
CTD
PMID:22517774
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
G
Igf1
insulin-like growth factor 1
decreases response to substance
ISO
Dantrolene results in decreased susceptibility to IGF1 protein
CTD
PMID:16485066
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
G
Igf2
insulin-like growth factor 2
decreases response to substance
ISO
Dantrolene results in decreased susceptibility to IGF2 protein
CTD
PMID:16485066
NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
G
Il10
interleukin 10
multiple interactions affects expression
ISO EXP
Dantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]] Dantrolene affects the expression of IL10 protein
CTD
PMID:17707769 PMID:25051504
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
G
Il1b
interleukin 1 beta
affects expression multiple interactions
EXP ISO
Dantrolene affects the expression of IL1B mRNA Dantrolene inhibits the reaction [Halothane results in increased expression of IL1B mRNA]
CTD
PMID:25051504 PMID:32795494
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il6
interleukin 6
multiple interactions
ISO
Dantrolene inhibits the reaction [taurolithocholic acid 3-sulfate results in increased expression of IL6 mRNA]
CTD
PMID:22517774
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
Dantrolene results in decreased activity of KCNH2 protein
CTD
PMID:24052561
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
G
Kcnj11
potassium inwardly-rectifying channel, subfamily J, member 11
multiple interactions
ISO
Dantrolene inhibits the reaction [KCNJ11 protein mutant form results in increased abundance of Calcium]
CTD
PMID:17189350
NCBI chr 1:96,591,048...96,594,574
Ensembl chr 1:96,591,049...96,594,082
G
Lep
leptin
decreases expression
EXP
Dantrolene results in decreased expression of LEP protein
CTD
PMID:25051504
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
G
Mef2a
myocyte enhancer factor 2a
multiple interactions
EXP
Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2A mRNA]; Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2A protein]
CTD
PMID:25093688
NCBI chr 1:120,847,874...120,982,488
Ensembl chr 1:120,850,080...120,981,948
G
Mef2c
myocyte enhancer factor 2C
multiple interactions
EXP
Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2C mRNA]; Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2C protein]
CTD
PMID:25093688
NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880
G
Myh7
myosin heavy chain 7
multiple interactions
EXP
Dantrolene inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]
CTD
PMID:25093688
NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
G
Nefl
neurofilament light chain
multiple interactions
EXP
Dantrolene inhibits the reaction [diphenylditelluride results in decreased phosphorylation of NEFL protein]; Dantrolene inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFL protein]
CTD
PMID:21863293 PMID:21879721
NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
G
Nefm
neurofilament medium chain
multiple interactions
EXP
Dantrolene inhibits the reaction [diphenylditelluride results in decreased phosphorylation of NEFM protein]; Dantrolene inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFM protein]
CTD
PMID:21863293 PMID:21879721
NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755
G
Nppa
natriuretic peptide A
multiple interactions
EXP
Dantrolene inhibits the reaction [Caffeine results in increased expression of NPPA mRNA]
CTD
PMID:25093688
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
G
Nppb
natriuretic peptide B
multiple interactions
EXP
Dantrolene inhibits the reaction [Caffeine results in increased expression of NPPB mRNA]
CTD
PMID:25093688
NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
G
Ryr1
ryanodine receptor 1
multiple interactions
ISO
Dantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]]; Dantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] which results in increased transport of Calcium]
CTD
PMID:17707769
NCBI chr 1:84,292,578...84,423,824
Ensembl chr 1:84,292,578...84,423,812
G
Ryr2
ryanodine receptor 2
multiple interactions
EXP
Dantrolene inhibits the reaction [Caffeine promotes the reaction [RYR2 protein results in increased secretion of Calcium]]
CTD
PMID:12887973
NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142
G
S100a8
S100 calcium binding protein A8
multiple interactions
ISO
Dantrolene inhibits the reaction [Halothane results in increased expression of S100A8 mRNA]
CTD
PMID:32795494
NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
G
S100a9
S100 calcium binding protein A9
multiple interactions
ISO
Dantrolene inhibits the reaction [Halothane results in increased expression of S100A9 mRNA]
CTD
PMID:32795494
NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
G
Star
steroidogenic acute regulatory protein
multiple interactions
ISO
Dantrolene inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR mRNA]
CTD
PMID:23183170
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
G
Tnf
tumor necrosis factor
decreases expression multiple interactions
EXP ISO
Dantrolene results in decreased expression of TNF protein Dantrolene inhibits the reaction [Halothane results in increased expression of TNF mRNA]
CTD
PMID:11236903 PMID:32795494
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Vcam1
vascular cell adhesion molecule 1
multiple interactions
ISO
Dantrolene inhibits the reaction [Halothane results in increased expression of VCAM1 mRNA]
CTD
PMID:32795494
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
G
Vim
vimentin
multiple interactions
EXP
Dantrolene inhibits the reaction [diphenylditelluride results in decreased phosphorylation of VIM protein]; Dantrolene inhibits the reaction [diphenylditelluride results in increased phosphorylation of VIM protein]
CTD
PMID:21863293 PMID:21879721
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
G
Xbp1
X-box binding protein 1
multiple interactions
ISO
Dantrolene inhibits the reaction [perfluorooctanoic acid results in increased expression of XBP1 mRNA alternative form]; Dantrolene inhibits the reaction [Thapsigargin results in increased expression of XBP1 mRNA alternative form]
CTD
PMID:32578922
NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
G
Chrm2
cholinergic receptor, muscarinic 2
multiple interactions
ISO
darifenacin binds to and results in decreased activity of CHRM2 protein
CTD
PMID:15140916
NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
G
Chrm3
cholinergic receptor, muscarinic 3
multiple interactions
ISO
darifenacin binds to and results in decreased activity of CHRM3 protein
CTD
PMID:11488427 PMID:15140916
NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278
G
Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
darifenacin results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
G
Bche
butyrylcholinesterase
decreases activity
ISO
decamethonium results in decreased activity of BCHE protein
CTD
PMID:31173753
NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
G
Chrna4
cholinergic receptor nicotinic alpha 4 subunit
multiple interactions
ISO
Carbachol inhibits the reaction [decamethonium binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; decamethonium binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; decamethonium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; decamethonium results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
CTD
PMID:14645658
NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
G
Chrnb2
cholinergic receptor nicotinic beta 2 subunit
multiple interactions
ISO
Carbachol inhibits the reaction [decamethonium binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; decamethonium binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; decamethonium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; decamethonium results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
CTD
PMID:14645658
NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
G
Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Dicyclomine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Akt1
AKT serine/threonine kinase 1
multiple interactions
ISO
Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein]
CTD
PMID:12511591
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Atoh1
atonal bHLH transcription factor 1
multiple interactions
ISO
Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased expression of ATOH1 mRNA]
CTD
PMID:23056257
NCBI chr 4:93,912,068...93,914,163
Ensembl chr 4:93,912,068...93,914,154
G
Ccnd1
cyclin D1
multiple interactions
ISO
Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of CCND1 mRNA]
CTD
PMID:23056257
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Cdk4
cyclin-dependent kinase 4
multiple interactions
ISO
Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of CDK4 protein]
CTD
PMID:15231866
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
G
Chrna2
cholinergic receptor nicotinic alpha 2 subunit
multiple interactions
EXP
dihydro-beta-erythroidine affects binding to Chrna2 protein; dihydro-beta-erythroidine inhibits the reaction [epibatidine affects binding to Chrna2 protein] in rat retina
RGD
PMID:16129735
RGD:2303195
NCBI chr15:40,342,317...40,358,601
Ensembl chr15:40,342,317...40,358,601
G
Chrna3
cholinergic receptor nicotinic alpha 3 subunit
multiple interactions
EXP
Dihydro-beta-Erythroidine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein] dihydro-beta-erythroidine affects binding [Epibatidine binds to Chrna3 protein]
CTD RGD
PMID:9687574 PMID:16129735 PMID:15016836
RGD:2303195 , RGD:2303194
NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165
G
Chrna4
cholinergic receptor nicotinic alpha 4 subunit
multiple interactions affects binding
ISO EXP
Carbachol inhibits the reaction [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine inhibits the reaction [1-Butanol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] dihydro-beta-erythroidine affects binding to Chrna4 protein; dihydro-beta-erythroidine inhibits the reaction [epibatidine affects binding to Chrna4 protein] in rat retina dihydro-beta-erythroidine affects binding to Chrna4 protein; dihydro-beta-erythroidine competes with [Epibatidine binds to Chrna4 protein] [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in decreased susceptibility to Nicotine; Dihydro-beta-Erythroidine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in increased expression of CHRNA4 mRNA]; Dihydro-beta-Erythroidine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; Dihydro-beta-Erythroidine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine inhibits the reaction [3-(2-(pyrrolidinyl)methoxy)pyridine analog results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] [CHRNA4 protein binds to CHRNB4 protein] which binds to Dihydro-beta-Erythroidine
CTD RGD
PMID:9687574 PMID:10945867 PMID:11600638 PMID:12604691 PMID:14645658 PMID:16569710 PMID:16915382 PMID:18385335 PMID:19047205 PMID:20100906 PMID:28555334 PMID:16129735 PMID:15016836 More...
RGD:2303195 , RGD:2303194
NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
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Chrna7
cholinergic receptor nicotinic alpha 7 subunit
increases activity multiple interactions affects response to substance
ISO EXP
Dihydro-beta-Erythroidine results in increased activity of CHRNA7 protein mutant form Dihydro-beta-Erythroidine affects the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein] CHRNA7 protein mutant form affects the susceptibility to Dihydro-beta-Erythroidine Dihydro-beta-Erythroidine binds to and results in decreased activity of CHRNA7 protein
CTD
PMID:10082212 PMID:19448648
NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240
G
Chrnb2
cholinergic receptor nicotinic beta 2 subunit
multiple interactions
ISO EXP
Carbachol inhibits the reaction [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine inhibits the reaction [1-Butanol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine inhibits the reaction [[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in decreased uptake of Calcium]; Dihydro-beta-Erythroidine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] dihydro-beta-erythroidine affects binding to Chrnb2 protein; dihydro-beta-erythroidine inhibits the reaction [epibatidine affects binding to Chrnb2 protein] in rat retina dihydro-beta-erythroidine affects binding to Chrnb2 protein; dihydro-beta-erythroidine competes with [Epibatidine binds to Chrnb2 protein] Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine inhibits the reaction [3-(2-(pyrrolidinyl)methoxy)pyridine analog results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in decreased susceptibility to Nicotine; Dihydro-beta-Erythroidine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; Dihydro-beta-Erythroidine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
CTD RGD
PMID:10945867 PMID:11600638 PMID:12604691 PMID:14645658 PMID:16569710 PMID:16915382 PMID:18385335 PMID:19047205 PMID:20100906 PMID:21715663 PMID:16129735 PMID:15016836 More...
RGD:2303195 , RGD:2303194
NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
G
Chrnb3
cholinergic receptor nicotinic beta 3 subunit
multiple interactions
EXP
dihydro-beta-erythroidine affects binding to Chrnb3 protein; dihydro-beta-erythroidine inhibits the reaction [epibatidine affects binding to Chrnb3 protein] in rat retina
RGD
PMID:16129735
RGD:2303195
NCBI chr16:64,713,438...64,751,360
Ensembl chr16:64,714,169...64,751,360
G
Chrnb4
cholinergic receptor nicotinic beta 4 subunit
affects binding multiple interactions
EXP
[CHRNA4 protein binds to CHRNB4 protein] which binds to Dihydro-beta-Erythroidine Dihydro-beta-Erythroidine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]
CTD
PMID:9687574
NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027
G
Cxcr4
C-X-C motif chemokine receptor 4
multiple interactions
ISO
[Mecamylamine co-treated with Dihydro-beta-Erythroidine co-treated with Bungarotoxins] inhibits the reaction [Nicotine results in increased expression of CXCR4 protein]
CTD
PMID:20457658
NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
G
Dnmt1
DNA methyltransferase 1
multiple interactions
EXP
Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in decreased expression of DNMT1 mRNA]
CTD
PMID:28555334
NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
G
Gad1
glutamate decarboxylase 1
multiple interactions
EXP
Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in increased expression of GAD1 mRNA]
CTD
PMID:28555334
NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
G
Slc6a3
solute carrier family 6 member 3
multiple interactions
EXP
Dihydro-beta-Erythroidine affects the reaction [Nicotine results in decreased activity of SLC6A3 protein]
CTD
PMID:23999947
NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
G
Tnfrsf11b
TNF receptor superfamily member 11B
multiple interactions
EXP
Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased expression of TNFRSF11B mRNA]
CTD
PMID:29981921
NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
G
Tnfsf11
TNF superfamily member 11
multiple interactions
EXP
Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of TNFSF11 mRNA]
CTD
PMID:29981921
NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445
G
Bax
BCL2 associated X, apoptosis regulator
increases expression increases localization multiple interactions
ISO
domoic acid results in increased expression of BAX mRNA domoic acid results in increased localization of BAX protein Carbachol inhibits the reaction [domoic acid results in increased localization of BAX protein]
CTD
PMID:18293405 PMID:19200344
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
G
Bcl2
BCL2, apoptosis regulator
affects expression
ISO
domoic acid affects the expression of BCL2 mRNA
CTD
PMID:18293405
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Casp3
caspase 3
multiple interactions increases activity
ISO
Carbachol inhibits the reaction [domoic acid results in increased activity of CASP3 protein]
CTD
PMID:19200344
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Gclc
glutamate-cysteine ligase, catalytic subunit
increases expression
ISO
domoic acid results in increased expression of GCLC mRNA; domoic acid results in increased expression of GCLC protein
CTD
PMID:23315585
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
G
Gclm
glutamate cysteine ligase, modifier subunit
increases expression decreases response to substance affects response to substance
ISO
domoic acid results in increased expression of GCLM mRNA; domoic acid results in increased expression of GCLM protein [GCLM protein results in decreased susceptibility to domoic acid] which results in decreased susceptibility to 2,3-dimethoxy-1,4-naphthoquinone; [GCLM protein results in decreased susceptibility to domoic acid] which results in decreased susceptibility to Hydrogen Peroxide; GCLM protein results in decreased susceptibility to domoic acid; GCLM results in decreased susceptibility to domoic acid GCLM affects the susceptibility to domoic acid
CTD
PMID:17804861 PMID:19200344 PMID:23315585
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
G
Gria1
glutamate ionotropic receptor AMPA type subunit 1
increases phosphorylation
EXP
domoic acid results in increased phosphorylation of GRIA1 protein
CTD
PMID:19564213
NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283
G
Pvalb
parvalbumin
increases expression
ISO
domoic acid results in increased expression of PVALB protein
CTD
PMID:26797589
NCBI chr 7:109,772,939...109,787,954
Ensembl chr 7:109,772,593...109,784,561
G
Wdr35
WD repeat domain 35
increases expression multiple interactions
EXP
domoic acid results in increased expression of WDR35 mRNA; domoic acid results in increased expression of WDR35 protein 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline inhibits the reaction [domoic acid results in increased expression of WDR35 protein]; Edaravone inhibits the reaction [domoic acid results in increased expression of WDR35 protein]
CTD
PMID:23289926
NCBI chr 6:31,771,315...31,831,450
Ensembl chr 6:31,771,360...31,831,029
G
Pparg
peroxisome proliferator-activated receptor gamma
affects binding
ISO
glycycoumarin binds to PPARG protein
CTD
PMID:14608046
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
G
Abcb11
ATP binding cassette subfamily B member 11
decreases activity multiple interactions
ISO
Midazolam results in decreased activity of ABCB11 protein Midazolam inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD
PMID:20829430 PMID:24014644
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
G
Abcb1a
ATP binding cassette subfamily B member 1A
increases expression
ISO
Midazolam results in increased expression of ABCB1 protein
CTD
PMID:8632764
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
G
Abcb6
ATP binding cassette subfamily B member 6
multiple interactions decreases metabolic processing
ISO
[ABCB6 gene mutant form results in decreased expression of CYP3A11 mRNA] inhibits the reaction [CYP3A11 protein results in increased metabolism of Midazolam]; [ABCB6 gene mutant form results in decreased expression of CYP3A11 protein] inhibits the reaction [CYP3A11 protein results in increased metabolism of Midazolam] ABCB6 gene mutant form results in decreased metabolism of Midazolam
CTD
PMID:25623066
NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924
G
Bcl2
BCL2, apoptosis regulator
increases expression
EXP
Midazolam results in increased expression of BCL2
CTD
PMID:17715682
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases activity
ISO
Midazolam results in decreased activity of CYP1A1 protein
CTD
PMID:18420780 PMID:33814510
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
G
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases activity
ISO
Midazolam results in decreased activity of CYP1B1 protein
CTD
PMID:18420780
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
G
Cyp2a3
cytochrome P450, family 2, subfamily a, polypeptide 3
decreases activity
ISO
Midazolam results in decreased activity of CYP2A4 protein
CTD
PMID:18420780
NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
G
Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
decreases activity
ISO
Midazolam results in decreased activity of CYP2B10 protein
CTD
PMID:18420780
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
G
Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
decreases activity
ISO
Midazolam results in decreased activity of CYP2C29 protein
CTD
PMID:18420780
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
G
Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
decreases activity
ISO
Midazolam results in decreased activity of CYP2D6 protein
CTD
PMID:18420780
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
increases metabolic processing
ISO
CYP2E1 protein results in increased metabolism of Midazolam
CTD
PMID:17590308
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases hydroxylation increases glucuronidation affects metabolic processing decreases abundance increases metabolic processing increases expression increases oxidation multiple interactions
EXP ISO
CYP3A2 protein results in increased hydroxylation of Midazolam CYP3A4 protein results in increased glucuronidation of Midazolam CYP3A4 gene polymorphism affects the metabolism of Midazolam; CYP3A4 protein affects the metabolism of Midazolam CYP3A4 protein results in decreased abundance of Midazolam CYP3A4 protein results in increased metabolism of Midazolam CYP3A4 protein results in increased hydroxylation of Midazolam Midazolam results in increased expression of CYP3A4 mRNA CYP3A4 protein results in increased oxidation of Midazolam [3-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [5-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [6-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [6-methylflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [7-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [[3-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[5-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[6-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[6-methylflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[7-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[alpha-naphthoflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[artemetin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[beta-Naphthoflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[chrysin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[eupatilin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[flavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[galangin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[nobiletin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[sinensetin analog results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[sinensetin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[tangeretin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [alpha-naphthoflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [artemetin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [beta-Naphthoflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [Carbamazepine results in increased expression of CYP3A4 protein] which results in decreased abundance of Midazolam; [chrysin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased abundance of 1-hydroxymethylmidazolam; [CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased abundance of 4-hydroxymidazolam; [CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam; [Dexamethasone results in increased expression of CYP3A4 protein] which results in decreased abundance of Midazolam; [eupatilin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [flavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [galangin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased hydroxylation of Midazolam; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Midazolam; [L 754394 results in decreased activity of CYP3A4 protein] which results in decreased hydroxylation of Midazolam; [nobiletin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [Pioglitazone results in increased expression of CYP3A4 protein] which results in decreased abundance of Midazolam; [Rifampin results in increased expression of CYP3A4 protein] which results in decreased abundance of Midazolam; [sinensetin analog results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [sinensetin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [tangeretin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; acacetin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; acacetin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; allyl methyl disulfide inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Amiodarone inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Apigenin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; Apigenin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Atorvastatin inhibits the reaction [CYP3A4 protein affects the metabolism of Midazolam]; bufalin promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; bufogenin promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; caryophyllene inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; cinobufagin promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; citral inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Curcumin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; CYP3A4 protein inhibits the reaction [Rifampin results in decreased hydroxylation of Midazolam]; deoxyelephantopin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Diltiazem inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; erdafitinib inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; erdafitinib inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Eucalyptol inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; flavanone inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; flavanone promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; flavone inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; flavone promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Fluvastatin inhibits the reaction [CYP3A4 protein affects the metabolism of Midazolam]; fructus schizandrae, radix ginseng, radix ophiopogonis drug combination affects the reaction [CYP3A4 protein affects the metabolism of Midazolam]; Fusidic Acid inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; galangin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; galangin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; gingerol inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased abundance of Midazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; Limonene inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Midazolam inhibits the reaction [CYP3A4 protein results in decreased methylation of Etoposide]; Midazolam inhibits the reaction [CYP3A4 protein results in decreased methylation of Teniposide]; Midazolam inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; Mifepristone inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Mifepristone inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; muscone promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; NADP deficiency inhibits the reaction [erdafitinib inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]]; NADP deficiency inhibits the reaction [erdafitinib inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]]; Oleanolic Acid inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; Pantoprazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; potassium ferricyanide inhibits the reaction [Diltiazem inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]]; potassium ferricyanide promotes the reaction [Diltiazem inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]]; rabeprazole-thioether inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Rifampin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Rifampin promotes the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; shexiang baoxin promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; Verapamil inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; YM 758 inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; zafirlukast inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam] shikonin inhibits the reaction [CYP3A2 protein results in increased hydroxylation of Midazolam]
CTD
PMID:8114683 PMID:10997946 PMID:11911841 PMID:12401345 PMID:12433797 PMID:12467917 PMID:12695342 PMID:15043991 PMID:15258107 PMID:15286053 PMID:15370959 PMID:15383492 PMID:15499178 PMID:15618748 PMID:15626586 PMID:15784650 PMID:15801540 PMID:15860655 PMID:15900284 PMID:15948934 PMID:16029222 PMID:16042670 PMID:16049126 PMID:16124035 PMID:17267297 PMID:17418993 PMID:17565714 PMID:17702393 PMID:18385293 PMID:19230594 PMID:19255940 PMID:19299527 PMID:19557931 PMID:20080160 PMID:20233841 PMID:21053930 PMID:21915887 PMID:22178124 PMID:22524704 PMID:22634058 PMID:22652334 PMID:23850985 PMID:23876819 PMID:25343516 PMID:26888941 PMID:26958860 PMID:27485346 PMID:28119166 PMID:28762043 PMID:28941798 PMID:29445054 PMID:30087611 PMID:31756459 PMID:34189909 More...
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a23-3a1
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
increases hydroxylation
EXP
CYP3A23-3A1 protein results in increased hydroxylation of Midazolam
CTD
PMID:11911841
NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
affects metabolic processing increases metabolic processing multiple interactions increases hydroxylation
ISO EXP
CYP3A5 gene polymorphism affects the metabolism of Midazolam; CYP3A5 protein affects the metabolism of Midazolam CYP3A5 protein results in increased metabolism of Midazolam [CYP3A5 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; erdafitinib inhibits the reaction [[CYP3A5 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; erdafitinib inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Midazolam]; fructus schizandrae, radix ginseng, radix ophiopogonis drug combination affects the reaction [CYP3A5 protein affects the metabolism of Midazolam]
CTD
PMID:15383492 PMID:15499178 PMID:15801540 PMID:15900284 PMID:19557931 PMID:26958860 PMID:34189909 More...
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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Gabra4
gamma-aminobutyric acid type A receptor subunit alpha 4
increases expression
ISO
Midazolam results in increased expression of GABRA4 mRNA
CTD
PMID:16733821
NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844
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Gabra6
gamma-aminobutyric acid type A receptor subunit alpha6
decreases response to substance
ISO
GABRA6 protein mutant form results in decreased susceptibility to Midazolam
CTD
PMID:12031754
NCBI chr10:26,810,411...26,825,768
Ensembl chr10:26,810,423...26,825,769
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Gabrb3
gamma-aminobutyric acid type A receptor subunit beta 3
increases response to substance
ISO
GABRB3 protein results in increased susceptibility to Midazolam
CTD
PMID:9523823
NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961
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Gabre
gamma-aminobutyric acid type A receptor subunit epsilon
decreases response to substance
EXP
GABRE protein results in decreased susceptibility to Midazolam
CTD
PMID:11691872
NCBI chr X:150,060,035...150,078,773
Ensembl chr X:150,060,040...150,078,693
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Gabrg2
gamma-aminobutyric acid type A receptor subunit gamma 2
affects response to substance affects binding
ISO
GABRG2 protein alternative form affects the susceptibility to Midazolam GABRG2 protein mutant form binds to Midazolam
CTD
PMID:10880692
NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346
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Gast
gastrin
multiple interactions
EXP
[fluanisone co-treated with Fentanyl co-treated with Midazolam] inhibits the reaction [GAST protein results in increased secretion of Histamine]
CTD
PMID:10864877
NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496
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Grin2a
glutamate ionotropic receptor NMDA type subunit 2A
affects response to substance
ISO
GRIN2A protein affects the susceptibility to Midazolam
CTD
PMID:15731593
NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637
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Itgam
integrin subunit alpha M
multiple interactions
ISO
[Midazolam cotreated with N-formyl-methionyl-leucyl-phenylalanine] decreases expression of ITGAM protein on neutrophils
RGD
PMID:20421794
RGD:329853762
NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases activity multiple interactions
ISO
Midazolam results in increased activity of NR1I2 protein NR1I2 gene promotes the reaction [Rifampin results in increased metabolism of Midazolam]
CTD
PMID:18799805 PMID:20080160
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
decreases metabolic processing
ISO
NR1I3 gene mutant form results in decreased metabolism of Midazolam
CTD
PMID:27434302
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Star
steroidogenic acute regulatory protein
increases expression
ISO
Midazolam results in increased expression of STAR protein
CTD
PMID:19857560
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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Syn1
synapsin I
decreases expression
EXP
Midazolam results in decreased expression of SYN1 protein
CTD
PMID:21920406
NCBI chr X:1,172,208...1,227,400
Ensembl chr X:1,172,208...1,227,396
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Trh
thyrotropin releasing hormone
multiple interactions
EXP
Midazolam inhibits the reaction [TRH protein modified form binds to TRHR protein]
CTD
PMID:2845442
NCBI chr 4:124,742,111...124,777,094
Ensembl chr 4:124,742,111...124,744,637
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Trhr
thyrotropin releasing hormone receptor
multiple interactions
EXP
Midazolam inhibits the reaction [TRH protein modified form binds to TRHR protein]
CTD
PMID:2845442
NCBI chr 7:75,348,672...75,393,310
Ensembl chr 7:75,348,672...75,393,309
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Tspo
translocator protein
increases expression multiple interactions affects binding
ISO EXP
Midazolam results in increased expression of TSPO protein [Ketamine co-treated with Midazolam co-treated with Valproic Acid] inhibits the reaction [[Sarin co-treated with [Atropine co-treated with trimethylene-bis(4-hydroxyiminomethylpyridinium)]] results in increased expression of TSPO protein] Midazolam binds to TSPO protein
CTD
PMID:7603229 PMID:19857560 PMID:33823148
NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450
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Casp3
caspase 3
multiple interactions
ISO
CYP3A4 protein affects the reaction [nimetazepam results in increased activity of CASP3 protein]
CTD
PMID:19005028
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp7
caspase 7
multiple interactions
ISO
CYP3A4 protein affects the reaction [nimetazepam results in increased activity of CASP7 protein]
CTD
PMID:19005028
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions
ISO
CYP3A4 protein affects the reaction [nimetazepam results in increased activity of CASP3 protein]; CYP3A4 protein affects the reaction [nimetazepam results in increased activity of CASP7 protein]; CYP3A4 protein results in increased metabolism of and results in increased activity of nimetazepam
CTD
PMID:19005028
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
nimetazepam inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Akr1c1
aldo-keto reductase family 1, member C1
decreases activity
ISO
Nitrazepam results in decreased activity of AKR1C1 protein
CTD
PMID:11995921
NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
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Akr1c2
aldo-keto reductase family 1, member C2
decreases activity
ISO
Nitrazepam results in decreased activity of AKR1C2 protein
CTD
PMID:11995921
NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
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Akr1c3
aldo-keto reductase family 1, member C3
decreases activity
ISO
Nitrazepam results in decreased activity of AKR1C3 protein
CTD
PMID:11995921
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
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Casp3
caspase 3
multiple interactions
ISO
CYP3A4 protein affects the reaction [Nitrazepam results in increased activity of CASP3 protein]
CTD
PMID:19005028
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp7
caspase 7
multiple interactions
ISO
CYP3A4 protein affects the reaction [Nitrazepam results in increased activity of CASP7 protein]
CTD
PMID:19005028
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions
ISO
CYP3A4 protein affects the reaction [Nitrazepam results in increased activity of CASP3 protein]; CYP3A4 protein affects the reaction [Nitrazepam results in increased activity of CASP7 protein]; CYP3A4 protein results in increased metabolism of and results in increased activity of Nitrazepam
CTD
PMID:19005028
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Esr1
estrogen receptor 1
multiple interactions
ISO
Nitrazepam binds to and results in increased activity of ESR1 protein
CTD
PMID:25752796
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Acat1
acetyl-CoA acetyltransferase 1
increases expression
EXP
Nitroglycerin results in increased expression of ACAT1 mRNA
CTD
PMID:12102619
NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855
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Actb
actin, beta
decreases expression
EXP
Nitroglycerin results in decreased expression of ACTB mRNA
CTD
PMID:12102619
NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
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Aldh1a1
aldehyde dehydrogenase 1 family, member A1
decreases expression
EXP
Nitroglycerin results in decreased expression of ALDH1A1 mRNA
CTD
PMID:12102619
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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Aldh2
aldehyde dehydrogenase 2 family member
multiple interactions decreases activity increases response to substance decreases expression affects metabolic processing affects response to substance
ISO EXP
[1-aminocyclopropanol analog results in decreased activity of ALDH2 protein] which results in decreased metabolism of Nitroglycerin; [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in decreased metabolism of Nitroglycerin; [Cyanamide results in decreased activity of ALDH2 protein] which results in decreased metabolism of Nitroglycerin; Acetylcysteine inhibits the reaction [Nitroglycerin results in decreased activity of ALDH2 protein]; ALDH2 protein affects the reaction [Nitroglycerin results in decreased abundance of Cyclic GMP] ALDH2 protein affects the reaction [Ascorbic Acid deficiency results in decreased susceptibility to Nitroglycerin] ALDH2 protein results in increased susceptibility to Nitroglycerin Nitroglycerin results in decreased expression of ALDH2 mRNA; Nitroglycerin results in decreased expression of ALDH2 protein ALDH2 protein affects the metabolism of and results in increased activity of Nitroglycerin; ALDH2 protein affects the reaction [Nitroglycerin results in increased abundance of Reactive Oxygen Species]; Hemin inhibits the reaction [Nitroglycerin results in decreased activity of ALDH2 protein] ALDH2 protein affects the metabolism of Nitroglycerin ALDH2 gene polymorphism affects the susceptibility to Nitroglycerin; ALDH2 protein affects the susceptibility to Nitroglycerin; ALDH2 protein polymorphism affects the susceptibility to Nitroglycerin
CTD
PMID:15331769 PMID:16440063 PMID:17092343 PMID:17493633 PMID:17541025 PMID:17585900 PMID:17967228 PMID:18272654 PMID:19576883 PMID:21156756 PMID:23194305 More...
NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
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Alox15
arachidonate 15-lipoxygenase
decreases expression
EXP
Nitroglycerin results in decreased expression of ALOX15 mRNA
CTD
PMID:12102619
NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
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Ap2m1
adaptor related protein complex 2 subunit mu 1
increases expression
EXP
Nitroglycerin results in increased expression of AP2M1 mRNA
CTD
PMID:12102619
NCBI chr11:80,355,307...80,364,218
Ensembl chr11:80,328,041...80,364,140
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Apex1
apurinic/apyrimidinic endodeoxyribonuclease 1
increases expression
EXP
Nitroglycerin results in increased expression of APEX1 mRNA
CTD
PMID:12102619
NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
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Apoa1
apolipoprotein A1
decreases expression
EXP
Nitroglycerin results in decreased expression of APOA1 mRNA
CTD
PMID:12102619
NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
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Arl2
ADP-ribosylation factor like GTPase 2
increases expression
EXP
Nitroglycerin results in increased expression of ARL2 mRNA
CTD
PMID:12102619
NCBI chr 1:203,434,129...203,446,156
Ensembl chr 1:203,434,129...203,446,119
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Atp5f1a
ATP synthase F1 subunit alpha
decreases expression
EXP
Nitroglycerin results in decreased expression of ATP5F1A mRNA
CTD
PMID:12102619
NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
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B2m
beta-2 microglobulin
affects expression
ISO
Nitroglycerin affects the expression of B2M protein
CTD
PMID:8350464
NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
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Bckdhb
branched chain keto acid dehydrogenase E1 subunit beta
decreases expression
EXP
Nitroglycerin results in decreased expression of BCKDHB mRNA
CTD
PMID:12102619
NCBI chr 8:84,845,264...85,027,812
Ensembl chr 8:84,845,264...85,027,812
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Bcl2
BCL2, apoptosis regulator
decreases expression
EXP
Nitroglycerin results in decreased expression of BCL2 protein
CTD
PMID:17678976
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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C3
complement C3
increases expression
ISO
Nitroglycerin results in increased expression of C3 protein alternative form
CTD
PMID:10884648
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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Calca
calcitonin-related polypeptide alpha
multiple interactions increases expression affects expression
EXP ISO
Capsaicin inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA]; Dexamethasone inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA]; Ergotamine inhibits the reaction [Nitroglycerin results in increased expression of CALCA protein]; Methylene Blue inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA]; NOS2 protein affects the reaction [Nitroglycerin results in increased expression of CALCA mRNA]; pimagedine inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA]; Plant Oils inhibits the reaction [Nitroglycerin results in increased expression of CALCA protein] Nitroglycerin results in increased expression of CALCA mRNA; Nitroglycerin results in increased expression of CALCA protein Nitroglycerin affects the expression of CALCA protein
CTD
PMID:11919648 PMID:14659530 PMID:14729435 PMID:19121572
NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
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Calm2
calmodulin 2
increases expression
EXP
Nitroglycerin results in increased expression of CALM2 mRNA
CTD
PMID:12102619
NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287 Ensembl chr15:7,091,567...7,104,287
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Capn2
calpain 2
decreases expression
EXP
Nitroglycerin results in decreased expression of CAPN2 mRNA
CTD
PMID:12102619
NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
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Casp1
caspase 1
multiple interactions
ISO
Nitroglycerin results in increased cleavage of and results in increased activity of CASP1 protein
CTD
PMID:12105852
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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Casp3
caspase 3
decreases expression multiple interactions
ISO
Nitroglycerin results in decreased expression of CASP3 protein modified form Nitroglycerin results in increased cleavage of and results in increased activity of CASP3 protein
CTD
PMID:12105852 PMID:17322376
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cat
catalase
multiple interactions
EXP
Nitroglycerin results in increased expression of and results in increased activity of CAT protein
CTD
PMID:12860443 PMID:14732477
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cd3d
CD3 delta subunit of T-cell receptor complex
increases expression
EXP
Nitroglycerin results in increased expression of CD3D mRNA
CTD
PMID:12102619
NCBI chr 8:45,287,803...45,293,342
Ensembl chr 8:45,288,749...45,301,809
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Cd5
Cd5 molecule
decreases expression
EXP
Nitroglycerin results in decreased expression of CD5 mRNA
CTD
PMID:12102619
NCBI chr 1:207,365,337...207,386,313
Ensembl chr 1:207,365,337...207,386,313
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Cd53
Cd53 molecule
decreases expression
EXP
Nitroglycerin results in decreased expression of CD53 mRNA
CTD
PMID:12102619
NCBI chr 2:194,352,139...194,399,668
Ensembl chr 2:194,352,139...194,399,657
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Cdc37
cell division cycle 37, HSP90 cochaperone
increases expression
EXP
Nitroglycerin results in increased expression of CDC37 mRNA
CTD
PMID:12102619
NCBI chr 8:19,677,400...19,690,761
Ensembl chr 8:19,671,938...19,690,809
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
increases expression
EXP
Nitroglycerin results in increased expression of CDKN1B mRNA
CTD
PMID:12102619
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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Celf2
CUGBP, Elav-like family member 2
increases expression
EXP
Nitroglycerin results in increased expression of CELF2 mRNA
CTD
PMID:12102619
NCBI chr17:70,904,462...71,729,072
Ensembl chr17:71,210,853...71,728,333
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Ckb
creatine kinase B
decreases expression
EXP
Nitroglycerin results in decreased expression of CKB mRNA
CTD
PMID:12102619
NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
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Clu
clusterin
decreases expression
EXP
Nitroglycerin results in decreased expression of CLU mRNA
CTD
PMID:12102619
NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
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Cnr1
cannabinoid receptor 1
multiple interactions
EXP
Nitroglycerin affects the reaction [glyceryl 2-arachidonate affects the activity of CNR1 protein]
CTD
PMID:16775503
NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
G
Cp
ceruloplasmin
decreases expression
EXP
Nitroglycerin results in decreased expression of CP mRNA
CTD
PMID:12102619
NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
G
Crip2
cysteine-rich protein 2
decreases expression
EXP
Nitroglycerin results in decreased expression of CRIP2 mRNA
CTD
PMID:12102619
NCBI chr 6:132,221,120...132,226,066
Ensembl chr 6:132,221,082...132,226,065
G
Ctnnb1
catenin beta 1
multiple interactions decreases localization
ISO
4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [Nitroglycerin results in decreased localization of CTNNB1 protein]; 4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [Nitroglycerin results in increased degradation of and results in decreased activity of CTNNB1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Nitroglycerin results in increased degradation of CTNNB1 protein]; Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]; Nitroglycerin results in decreased phosphorylation of and results in increased nitrosation of and results in increased degradation of and results in decreased activity of CTNNB1 protein; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin results in decreased localization of CTNNB1 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin results in increased degradation of and results in decreased activity of CTNNB1 protein]
CTD
PMID:17030184
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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Ctsd
cathepsin D
decreases expression
EXP
Nitroglycerin results in decreased expression of CTSD mRNA
CTD
PMID:12102619
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
G
Cybb
cytochrome b-245 beta chain
multiple interactions decreases expression increases expression decreases response to substance
ISO EXP
CYBB gene mutant form inhibits the reaction [Nitroglycerin results in decreased susceptibility to Acetylcholine]; Rosuvastatin Calcium inhibits the reaction [Nitroglycerin results in increased expression of CYBB mRNA] Nitroglycerin results in decreased expression of CYBB mRNA CYBB gene mutant form results in decreased susceptibility to Nitroglycerin
CTD
PMID:16633368 PMID:17493633 PMID:18522491
NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
G
Cyp11b3
cytochrome P450, family 11, subfamily b, polypeptide 3
decreases expression
EXP
Nitroglycerin results in decreased expression of CYP11B2 mRNA
CTD
PMID:12102619
NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
affects expression decreases expression
EXP
Vitamin E inhibits the reaction [nitroglycerine decreases Cyp1a2 protein expression in rat heart] nitroglycerin decreased expression of Cyp1a2 protein in thoracic aorta of rats
RGD
PMID:16520233 PMID:12688525
RGD:401900296 , RGD:401900656
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
G
Cyp2b15
cytochrome P450, family 2, subfamily b, polypeptide 15
decreases expression
EXP
Nitroglycerin results in decreased expression of CYP2B15 mRNA
CTD
PMID:12102619
NCBI chr 1:82,094,188...82,106,492
Ensembl chr 1:82,094,180...82,106,492
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
increases expression
EXP
Nitroglycerin results in increased expression of CYP2E1 mRNA
CTD
PMID:12102619
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
G
Defb5
defensin beta 5
decreases expression
EXP
Nitroglycerin results in decreased expression of DEFB4 mRNA
CTD
PMID:12102619
NCBI chr16:70,612,985...70,615,389
Ensembl chr16:70,613,146...70,615,467
G
Dhcr7
7-dehydrocholesterol reductase
decreases expression
EXP
Nitroglycerin results in decreased expression of DHCR7 mRNA
CTD
PMID:12102619
NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
G
Dync1i1
dynein cytoplasmic 1 intermediate chain 1
decreases expression
EXP
Nitroglycerin results in decreased expression of DYNC1I1 mRNA
CTD
PMID:12102619
NCBI chr 4:33,852,597...34,166,159
Ensembl chr 4:33,852,927...34,166,149
G
Dyrk1a
dual specificity tyrosine phosphorylation regulated kinase 1A
decreases expression
EXP
Nitroglycerin results in decreased expression of DYRK1A mRNA
CTD
PMID:12102619
NCBI chr11:33,890,706...34,009,420
Ensembl chr11:33,890,490...34,009,420
G
Edn1
endothelin 1
decreases expression increases expression multiple interactions
ISO EXP
Nitroglycerin results in decreased expression of EDN1 mRNA Nitroglycerin results in increased expression of EDN1 protein Nitroglycerin results in decreased expression of EDN1 mRNA; Nitroglycerin results in decreased expression of EDN1 protein Losartan inhibits the reaction [Nitroglycerin results in increased expression of EDN1 protein]
CTD
PMID:11751199 PMID:12206003 PMID:12901495
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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Elane
elastase, neutrophil expressed
increases expression
ISO
Nitroglycerin results in increased expression of ELANE protein
CTD
PMID:10884648
NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100
G
Eln
elastin
increases expression
EXP
Nitroglycerin results in increased expression of ELN mRNA
CTD
PMID:12187120
NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928
G
Faah
fatty acid amide hydrolase
increases activity multiple interactions
EXP
Nitroglycerin results in increased activity of FAAH protein Nitroglycerin promotes the reaction [FAAH protein results in increased chemical synthesis of Arachidonic Acid]; Nitroglycerin promotes the reaction [FAAH protein results in increased degradation of anandamide]
CTD
PMID:19515121
NCBI chr 5:129,479,774...129,499,018
Ensembl chr 5:129,479,824...129,498,677
G
Fas
Fas cell surface death receptor
multiple interactions
ISO
Nitroglycerin results in increased expression of and results in increased localization of FAS protein
CTD
PMID:12105852
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
G
Fgfr2
fibroblast growth factor receptor 2
increases expression
EXP
Nitroglycerin results in increased expression of FGFR2 mRNA
CTD
PMID:12102619
NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
G
Fmo1
flavin containing dimethylaniline monoxygenase 1
decreases expression
EXP
Nitroglycerin results in decreased expression of FMO1 mRNA
CTD
PMID:12102619
NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
increases expression multiple interactions
ISO EXP
Nitroglycerin results in increased expression of FOS protein anandamide inhibits the reaction [Nitroglycerin results in increased expression of FOS protein]; Ergotamine inhibits the reaction [Nitroglycerin results in increased expression of FOS protein]; Plant Oils inhibits the reaction [Nitroglycerin results in increased expression of FOS protein]; Pregabalin inhibits the reaction [Nitroglycerin results in increased expression of FOS protein]
CTD
PMID:7552308 PMID:10426492 PMID:16897600 PMID:18761334 PMID:19121572 PMID:19489890 PMID:19515121 PMID:25290014 More...
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
G
Gchfr
GTP cyclohydrolase I feedback regulator
decreases expression
EXP
Nitroglycerin results in decreased expression of GCHFR mRNA
CTD
PMID:12102619
NCBI chr 3:106,158,046...106,162,080
Ensembl chr 3:106,159,394...106,162,080
G
Gnb3
G protein subunit beta 3
affects response to substance
ISO
GNB3 protein affects the susceptibility to Nitroglycerin
CTD
PMID:14586390
NCBI chr 4:157,639,468...157,645,171
Ensembl chr 4:157,639,469...157,645,173
G
Gng7
G protein subunit gamma 7
decreases expression
EXP
Nitroglycerin results in decreased expression of GNG7 mRNA
CTD
PMID:12102619
NCBI chr 7:8,697,458...8,761,239
Ensembl chr 7:8,697,521...8,761,240
G
Gpx1
glutathione peroxidase 1
decreases response to substance
ISO
GPX1 gene mutant form results in decreased susceptibility to Nitroglycerin
CTD
PMID:24296279
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
G
Grk6
G protein-coupled receptor kinase 6
decreases expression
EXP
Nitroglycerin results in decreased expression of GRK6 mRNA
CTD
PMID:12102619
NCBI chr17:9,177,018...9,192,813
Ensembl chr17:9,177,019...9,192,644
G
Grn
granulin precursor
decreases expression
EXP
Nitroglycerin results in decreased expression of GRN mRNA
CTD
PMID:12102619
NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775
G
Gsn
gelsolin
increases expression
EXP
Nitroglycerin results in increased expression of GSN mRNA
CTD
PMID:12187120
NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
G
Gsta2
glutathione S-transferase alpha 2
decreases expression
EXP
Nitroglycerin results in decreased expression of GSTA2 mRNA
CTD
PMID:12102619
NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
G
Gsta3
glutathione S-transferase alpha 3
affects metabolic processing
EXP
GSTA3 protein affects the metabolism of Nitroglycerin
CTD
PMID:8968379
NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
G
Gstm2
glutathione S-transferase mu 2
affects metabolic processing
EXP
GSTM2 protein affects the metabolism of Nitroglycerin
CTD
PMID:8968379
NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
G
Gtf3c1
general transcription factor IIIC subunit 1
increases expression
EXP
Nitroglycerin results in increased expression of GTF3C1 mRNA
CTD
PMID:12102619
NCBI chr 1:180,203,995...180,270,201
Ensembl chr 1:180,203,995...180,270,201
G
Gucy1a1
guanylate cyclase 1 soluble subunit alpha 1
increases expression
EXP
Nitroglycerin results in increased expression of GUCY1A1 mRNA; Nitroglycerin results in increased expression of GUCY1A1 protein
CTD
PMID:11331261
NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671
G
Gucy1b1
guanylate cyclase 1 soluble subunit beta 1
increases expression
ISO EXP
Nitroglycerin results in increased expression of GUCY1B1 protein Nitroglycerin results in increased expression of GUCY1B1 mRNA; Nitroglycerin results in increased expression of GUCY1B1 protein
CTD
PMID:11331261 PMID:11742226 PMID:17541025
NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916
G
Hbb
hemoglobin subunit beta
increases expression
EXP
Nitroglycerin results in increased expression of HBB mRNA
CTD
PMID:12187120
NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012
G
Hdc
histidine decarboxylase
decreases expression
EXP
Nitroglycerin results in decreased expression of HDC mRNA
CTD
PMID:12102619
NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341
G
Hmox1
heme oxygenase 1
increases expression multiple interactions
ISO EXP
Nitroglycerin results in increased expression of HMOX1 mRNA [Hemin co-treated with Nitroglycerin] results in increased expression of HMOX1 mRNA; [Hemin co-treated with Nitroglycerin] results in increased expression of HMOX1 protein
CTD
PMID:17092343 PMID:17470570 PMID:17541025
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
G
Hpn
hepsin
increases expression
EXP
Nitroglycerin results in increased expression of HPN mRNA
CTD
PMID:12102619
NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811
G
Iapp
islet amyloid polypeptide
increases expression
EXP
Nitroglycerin results in increased expression of IAPP mRNA
CTD
PMID:12102619
NCBI chr 4:175,237,107...175,244,373
Ensembl chr 4:175,237,115...175,242,920
G
Id2
inhibitor of DNA binding 2
increases expression
EXP
Nitroglycerin results in increased expression of ID2 mRNA
CTD
PMID:12102619
NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
G
Ido1
indoleamine 2,3-dioxygenase 1
decreases expression
EXP
Nitroglycerin results in decreased expression of IDO1 protein
CTD
PMID:28659861
NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730
G
Il1b
interleukin 1 beta
increases expression
EXP
Nitroglycerin results in increased expression of IL1B protein
CTD
PMID:11701602
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il6
interleukin 6
increases expression
ISO EXP
Nitroglycerin results in increased expression of IL6 mRNA; Nitroglycerin results in increased expression of IL6 protein
CTD
PMID:11701602 PMID:17470570
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Jtb
jumping translocation breakpoint
increases expression
EXP
Nitroglycerin results in increased expression of JTB mRNA
CTD
PMID:12102619
NCBI chr 2:175,685,392...175,689,609
Ensembl chr 2:175,684,993...175,690,108
G
Kmo
kynurenine 3-monooxygenase
decreases expression
EXP
Nitroglycerin results in decreased expression of KMO protein
CTD
PMID:28659861
NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881
G
Kng2
kininogen 2
decreases expression
EXP
Nitroglycerin results in decreased expression of KNG2 mRNA
CTD
PMID:12102619
NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971
G
Kynu
kynureninase
decreases expression
EXP
Nitroglycerin results in decreased expression of KYNU protein
CTD
PMID:28659861
NCBI chr 3:27,778,646...27,929,470
Ensembl chr 3:27,778,772...27,929,488
G
Maob
monoamine oxidase B
increases expression
EXP
Nitroglycerin results in increased expression of MAOB mRNA
CTD
PMID:12102619
NCBI chr X:5,907,327...6,010,996
Ensembl chr X:5,907,266...6,011,003
G
Mecr
mitochondrial trans-2-enoyl-CoA reductase
decreases expression
EXP
Nitroglycerin results in decreased expression of MECR mRNA
CTD
PMID:12102619
NCBI chr 5:144,029,684...144,056,373
Ensembl chr 5:144,029,731...144,055,863
G
Mgll
monoglyceride lipase
multiple interactions increases activity
EXP
Nitroglycerin promotes the reaction [MGLL protein results in increased chemical synthesis of Glycerol]; Nitroglycerin promotes the reaction [MGLL protein results in increased degradation of 2-oleoylglycerol] Nitroglycerin results in increased activity of MGLL protein
CTD
PMID:19515121
NCBI chr 4:121,192,186...121,294,187
Ensembl chr 4:121,192,195...121,294,179
G
Mmp2
matrix metallopeptidase 2
increases expression
ISO
Nitroglycerin results in increased expression of MMP2 mRNA
CTD
PMID:12084592
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
G
Mmp7
matrix metallopeptidase 7
increases expression
ISO
Nitroglycerin results in increased expression of MMP7 mRNA
CTD
PMID:12084592
NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
G
Mmp9
matrix metallopeptidase 9
increases activity increases expression
ISO
Nitroglycerin results in increased activity of MMP9 protein Nitroglycerin results in increased expression of MMP9 mRNA
CTD
PMID:12084592
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
G
Mpo
myeloperoxidase
decreases activity
EXP
Nitroglycerin results in decreased activity of MPO protein
CTD
PMID:8869312
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
G
Mxi1
MAX interactor 1, dimerization protein
increases expression
EXP
Nitroglycerin results in increased expression of MXI1 mRNA
CTD
PMID:12102619
NCBI chr 1:252,323,915...252,383,682
Ensembl chr 1:252,323,303...252,383,681
G
Myo9b
myosin IXb
decreases expression
EXP
Nitroglycerin results in decreased expression of MYO9B mRNA
CTD
PMID:12102619
NCBI chr16:17,945,379...18,030,114
Ensembl chr16:17,945,448...18,030,126
G
Ncam1
neural cell adhesion molecule 1
increases expression
EXP
Nitroglycerin results in increased expression of NCAM1 mRNA
CTD
PMID:12102619
NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014
G
Ncf1
neutrophil cytosolic factor 1
decreases response to substance multiple interactions
ISO
NCF1 gene mutant form results in decreased susceptibility to Nitroglycerin NCF1 gene mutant form inhibits the reaction [Nitroglycerin results in decreased susceptibility to Acetylcholine]
CTD
PMID:18522491
NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
G
Ndufa5
NADH:ubiquinone oxidoreductase subunit A5
decreases expression
EXP
Nitroglycerin results in decreased expression of NDUFA5 mRNA
CTD
PMID:12102619
NCBI chr 4:52,997,327...53,005,685
Ensembl chr 4:52,995,546...53,005,598
G
Nkx2-1
NK2 homeobox 1
decreases expression
EXP
Nitroglycerin results in decreased expression of NKX2-1 mRNA
CTD
PMID:12102619
NCBI chr 6:73,996,601...74,001,483
Ensembl chr 6:73,996,601...73,999,791
G
Nnat
neuronatin
increases expression
EXP
Nitroglycerin results in increased expression of NNAT mRNA
CTD
PMID:12102619
NCBI chr 3:146,225,941...146,228,868
Ensembl chr 3:146,226,407...146,228,834
G
Nos1
nitric oxide synthase 1
multiple interactions increases expression
EXP
acetylsalicylic acid lysinate inhibits the reaction [Nitroglycerin results in increased expression of NOS1 protein]; Sumatriptan inhibits the reaction [Nitroglycerin results in increased expression of NOS1 protein]
CTD
PMID:14510930 PMID:15154853
NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
G
Nos2
nitric oxide synthase 2
decreases expression multiple interactions increases expression
ISO EXP
Nitroglycerin results in decreased expression of NOS2 mRNA NOS2 protein affects the reaction [Nitroglycerin results in increased expression of CALCA mRNA] Nitroglycerin results in increased expression of NOS2 mRNA; Nitroglycerin results in increased expression of NOS2 protein Nitroglycerin results in decreased expression of NOS2 protein
CTD
PMID:11701602 PMID:12206003 PMID:14729435 PMID:14732477
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
G
Nos3
nitric oxide synthase 3
multiple interactions increases expression
EXP
[Nitroglycerin co-treated with Hemin] results in increased expression of NOS3 mRNA; Nitroglycerin promotes the reaction [[Calcimycin results in increased activity of NOS3 protein] which results in increased abundance of Superoxides] Nitroglycerin results in increased expression of NOS3 mRNA; Nitroglycerin results in increased expression of NOS3 protein
CTD
PMID:10625313 PMID:12860443 PMID:14732477 PMID:17541025
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
G
Nox1
NADPH oxidase 1
decreases expression
EXP
Nitroglycerin results in decreased expression of NOX1 mRNA
CTD
PMID:17493633
NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236
G
Nox4
NADPH oxidase 4
decreases expression
EXP
Nitroglycerin results in decreased expression of NOX4 mRNA
CTD
PMID:17493633
NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
G
Npy
neuropeptide Y
increases expression
EXP
Nitroglycerin results in increased expression of NPY protein
CTD
PMID:10426492
NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
G
Paics
phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
increases expression
EXP
Nitroglycerin results in increased expression of PAICS mRNA
CTD
PMID:12102619
NCBI chr14:31,199,086...31,232,731
Ensembl chr14:31,173,541...31,232,635
G
Parp1
poly (ADP-ribose) polymerase 1
decreases expression
ISO
Nitroglycerin results in decreased expression of PARP1 protein alternative form
CTD
PMID:17322376
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
G
Pcsk1n
proprotein convertase subtilisin/kexin type 1 inhibitor
decreases expression
EXP
Nitroglycerin results in decreased expression of PCSK1N mRNA
CTD
PMID:12102619
NCBI chr X:14,580,036...14,583,478
Ensembl chr X:14,580,038...14,583,566
G
Pde1a
phosphodiesterase 1A
increases expression multiple interactions
EXP
Nitroglycerin results in increased expression of PDE1A mRNA; Nitroglycerin results in increased expression of PDE1A protein PDE1A protein inhibits the reaction [Nitroglycerin results in increased abundance of Cyclic GMP]
CTD
PMID:11696475
NCBI chr 3:64,745,140...65,025,178
Ensembl chr 3:64,747,269...65,024,874
G
Pde2a
phosphodiesterase 2A
increases expression
EXP
Nitroglycerin results in increased expression of PDE2A mRNA
CTD
PMID:12102619
NCBI chr 1:155,823,590...155,915,434
Ensembl chr 1:155,813,180...155,915,434
G
Pla2g1b
phospholipase A2 group IB
increases expression
EXP
Nitroglycerin results in increased expression of PLA2G1B mRNA
CTD
PMID:12102619
NCBI chr12:41,142,193...41,151,967
Ensembl chr12:41,142,200...41,153,226
G
Plaur
plasminogen activator, urokinase receptor
increases expression
EXP
Nitroglycerin results in increased expression of PLAUR mRNA
CTD
PMID:12102619
NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595
G
Pmp22
peripheral myelin protein 22
decreases expression
EXP
Nitroglycerin results in decreased expression of PMP22 mRNA
CTD
PMID:12102619
NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714
G
Polr1b
RNA polymerase I subunit B
increases expression
EXP
Nitroglycerin results in increased expression of POLR1B mRNA
CTD
PMID:12102619
NCBI chr 3:116,333,910...116,358,385
Ensembl chr 3:116,333,889...116,358,379
G
Ppp2cb
protein phosphatase 2 catalytic subunit beta
decreases expression
EXP
Nitroglycerin results in decreased expression of PPP2CB mRNA
CTD
PMID:12102619
NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576
G
Prkg1
protein kinase cGMP-dependent 1
decreases expression
EXP
Nitroglycerin results in decreased expression of PRKG1 protein
CTD
PMID:11331261
NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080
G
Ptgds
prostaglandin D2 synthase
increases expression
EXP
Nitroglycerin results in increased expression of PTGDS mRNA
CTD
PMID:12102619
NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833
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Ptprr
protein tyrosine phosphatase, receptor type, R
increases expression
EXP
Nitroglycerin results in increased expression of PTPRR mRNA
CTD
PMID:12102619
NCBI chr 7:51,662,595...51,929,605
Ensembl chr 7:51,662,595...51,929,603
G
Rab40c
Rab40c, member RAS oncogene family
increases expression
EXP
Nitroglycerin results in increased expression of RAB40C mRNA
CTD
PMID:12187120
NCBI chr10:14,900,926...14,936,153
Ensembl chr10:14,900,929...14,936,557
G
Reg3b
regenerating family member 3 beta
increases expression
EXP
Nitroglycerin results in increased expression of REG3B mRNA
CTD
PMID:12102619
NCBI chr 4:110,861,775...110,865,015
Ensembl chr 4:110,861,775...110,865,015
G
Rela
RELA proto-oncogene, NF-kB subunit
increases localization multiple interactions
EXP
Nitroglycerin results in increased localization of RELA protein Atorvastatin inhibits the reaction [Nitroglycerin results in increased localization of RELA protein]
CTD
PMID:19733216
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Ren
renin
increases activity
ISO
Nitroglycerin results in increased activity of REN protein
CTD
PMID:9527094
NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
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Rgs8
regulator of G-protein signaling 8
increases expression
EXP
Nitroglycerin results in increased expression of RGS8 mRNA
CTD
PMID:12102619
NCBI chr13:65,804,703...65,848,955
Ensembl chr13:65,804,797...65,846,807
G
Rheb
Ras homolog, mTORC1 binding
decreases expression
EXP
Nitroglycerin results in decreased expression of RHEB mRNA
CTD
PMID:12102619
NCBI chr 4:10,278,970...10,320,160
Ensembl chr 4:10,279,370...10,320,160
G
Rpl6
ribosomal protein L6
decreases expression
EXP
Nitroglycerin results in decreased expression of RPL6 mRNA
CTD
PMID:12102619
NCBI chr12:35,347,493...35,352,011
Ensembl chr12:35,347,497...35,351,921
G
Rps3a
ribosomal protein S3a
increases expression
EXP
Nitroglycerin results in increased expression of RPS3A mRNA
CTD
PMID:12102619
NCBI chr 2:171,524,685...171,529,054
Ensembl chr 2:171,524,500...171,529,055
G
Scgb1a1
secretoglobin family 1A member 1
decreases expression
EXP
Nitroglycerin results in decreased expression of SCGB1A1 mRNA
CTD
PMID:12102619
NCBI chr 1:205,977,060...205,980,610
Ensembl chr 1:205,977,060...205,980,610
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Sdc4
syndecan 4
decreases expression
EXP
Nitroglycerin results in decreased expression of SDC4 mRNA
CTD
PMID:12102619
NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580
G
Serpina3n
serine (or cysteine) peptidase inhibitor, clade A, member 3N
decreases expression
EXP
Nitroglycerin results in decreased expression of SERPINA3N mRNA
CTD
PMID:12102619
NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433
G
Shank2
SH3 and multiple ankyrin repeat domains 2
increases expression
EXP
Nitroglycerin results in increased expression of SHANK2 mRNA
CTD
PMID:12102619
NCBI chr 1:199,146,210...199,590,962
Ensembl chr 1:199,169,429...199,589,394
G
Slc4a4
solute carrier family 4 member 4
increases expression
EXP
Nitroglycerin results in increased expression of SLC4A4 mRNA
CTD
PMID:12102619
NCBI chr14:18,841,289...19,293,297
Ensembl chr14:18,845,159...19,272,883
G
Snn
stannin
decreases expression
EXP
Nitroglycerin results in decreased expression of SNN mRNA
CTD
PMID:12102619
NCBI chr10:4,572,933...4,581,606
Ensembl chr10:4,572,376...4,584,021
G
Snrk
SNF related kinase
increases expression
EXP
Nitroglycerin results in increased expression of SNRK mRNA
CTD
PMID:12102619
NCBI chr 8:121,779,704...121,833,949
Ensembl chr 8:121,793,302...121,832,323
G
Sod2
superoxide dismutase 2
multiple interactions
EXP
Nitroglycerin results in increased expression of and results in increased activity of SOD2 protein
CTD
PMID:12860443 PMID:14732477
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
G
Stat3
signal transducer and activator of transcription 3
increases expression
EXP
Nitroglycerin results in increased expression of STAT3 mRNA
CTD
PMID:12102619
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
G
Syk
spleen associated tyrosine kinase
increases expression
EXP
Nitroglycerin results in increased expression of SYK mRNA
CTD
PMID:12102619
NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410
G
Syn2
synapsin II
increases expression
EXP
Nitroglycerin results in increased expression of SYN2 mRNA
CTD
PMID:12102619
NCBI chr 4:148,178,846...148,347,010
Ensembl chr 4:148,186,270...148,344,192
G
Tac1
tachykinin, precursor 1
affects expression
EXP
Nitroglycerin affects the expression of TAC1 protein
CTD
PMID:18197882
NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
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Tcf4
transcription factor 4
multiple interactions
ISO
Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]]
CTD
PMID:17030184
NCBI chr18:62,941,739...63,288,126
Ensembl chr18:62,943,782...63,284,425
G
Tdo2
tryptophan 2,3-dioxygenase
decreases expression
EXP
Nitroglycerin results in decreased expression of TDO2 protein
CTD
PMID:28659861
NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511
G
Thy1
Thy-1 cell surface antigen
decreases expression
EXP
Nitroglycerin results in decreased expression of THY1 mRNA
CTD
PMID:12102619
NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659
G
Tmpo
thymopoietin
increases expression
EXP
Nitroglycerin results in increased expression of TMPO mRNA
CTD
PMID:12102619
NCBI chr 7:25,642,752...25,667,756
Ensembl chr 7:25,586,725...25,667,727
G
Tnf
tumor necrosis factor
decreases expression multiple interactions
ISO EXP
Nitroglycerin results in decreased expression of TNF protein Capsaicin inhibits the reaction [Nitroglycerin results in decreased expression of TNF protein]; Methylene Blue inhibits the reaction [Nitroglycerin results in decreased expression of TNF protein]
CTD
PMID:10884648 PMID:11744139
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Tnfrsf8
TNF receptor superfamily member 8
decreases expression
EXP
Nitroglycerin results in decreased expression of TNFRSF8 mRNA
CTD
PMID:12102619
NCBI chr 5:157,123,183...157,168,421
Ensembl chr 5:157,123,185...157,168,421
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Umod
uromodulin
increases expression
EXP
Nitroglycerin results in increased expression of UMOD mRNA
CTD
PMID:12102619
NCBI chr 1:173,816,341...173,829,681
Ensembl chr 1:173,816,339...173,830,302
G
Vasp
vasodilator-stimulated phosphoprotein
multiple interactions increases phosphorylation decreases phosphorylation
ISO EXP
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitroglycerin results in increased phosphorylation of VASP protein] Nitroglycerin results in decreased phosphorylation of VASP protein Benomyl inhibits the reaction [Nitroglycerin results in increased phosphorylation of VASP protein]; Hemin inhibits the reaction [Nitroglycerin results in decreased phosphorylation of VASP protein]
CTD
PMID:11331261 PMID:14551241 PMID:15331769 PMID:17541025 PMID:17868048 PMID:20129490 More...
NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061
G
Vtn
vitronectin
increases expression
EXP
Nitroglycerin results in increased expression of VTN mRNA
CTD
PMID:12102619
NCBI chr10:63,394,732...63,397,812
Ensembl chr10:63,394,719...63,397,810
G
Ywhaz
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
decreases expression
EXP
Nitroglycerin results in decreased expression of YWHAZ mRNA
CTD
PMID:12102619
NCBI chr 7:67,941,353...67,963,651
Ensembl chr 7:67,940,017...67,963,668
G
A1bgl1
alpha-1-B glycoprotein like 1
affects expression
EXP
Orphenadrine affects the expression of A1BGL1 mRNA
CTD
PMID:23665939
NCBI chr 7:92,314,930...92,318,652
G
A2m
alpha-2-macroglobulin
affects expression
EXP
Orphenadrine affects the expression of A2M mRNA
CTD
PMID:23665939
NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
G
Abcb1b
ATP-binding cassette, sub-family B member 1B
affects expression
EXP
Orphenadrine affects the expression of ABCB1B mRNA
CTD
PMID:23665939
NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
G
Abcc2
ATP binding cassette subfamily C member 2
multiple interactions
EXP
[Orphenadrine co-treated with Diethylnitrosamine] results in increased expression of ABCC2 mRNA
CTD
PMID:23665939
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
G
Abcc3
ATP binding cassette subfamily C member 3
affects expression
EXP
Orphenadrine affects the expression of ABCC3 mRNA
CTD
PMID:23665939
NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
G
Abcd2
ATP binding cassette subfamily D member 2
affects expression
EXP
Orphenadrine affects the expression of ABCD2 mRNA
CTD
PMID:23665939
NCBI chr 7:122,263,034...122,311,642
Ensembl chr 7:122,263,032...122,311,642
G
Ablim3
actin binding LIM protein family, member 3
affects expression
EXP
Orphenadrine affects the expression of ABLIM3 mRNA
CTD
PMID:23665939
NCBI chr18:55,256,135...55,376,629
Ensembl chr18:55,257,583...55,376,380
G
Ace2
angiotensin converting enzyme 2
affects expression
EXP
Orphenadrine affects the expression of ACE2 mRNA
CTD
PMID:23665939
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
G
Acer3
alkaline ceramidase 3
affects expression
EXP
Orphenadrine affects the expression of ACER3 mRNA
CTD
PMID:23665939
NCBI chr 1:152,504,180...152,606,596
Ensembl chr 1:152,504,186...152,606,591
G
Acsl5
acyl-CoA synthetase long-chain family member 5
affects expression
EXP
Orphenadrine affects the expression of ACSL5 mRNA
CTD
PMID:23665939
NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607
G
Acsm3
acyl-CoA synthetase medium-chain family member 3
affects expression
EXP
Orphenadrine affects the expression of ACSM3 mRNA
CTD
PMID:23665939
NCBI chr 1:174,133,260...174,159,966
Ensembl chr 1:174,133,288...174,160,184
G
Adgrg2
adhesion G protein-coupled receptor G2
affects expression
EXP
Orphenadrine affects the expression of ADGRG2 mRNA
CTD
PMID:23665939
NCBI chr X:34,297,402...34,422,590
Ensembl chr X:34,297,402...34,422,609
G
Adgrv1
adhesion G protein-coupled receptor V1
affects expression
EXP
Orphenadrine affects the expression of ADGRV1 mRNA
CTD
PMID:23665939
NCBI chr 2:11,331,434...11,911,713
Ensembl chr 2:11,331,442...11,911,688
G
Adh4
alcohol dehydrogenase 4 (class II), pi polypeptide
affects expression
EXP
Orphenadrine affects the expression of ADH4 mRNA
CTD
PMID:23665939
NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591
G
Adora1
adenosine A1 receptor
affects expression
EXP
Orphenadrine affects the expression of ADORA1 mRNA
CTD
PMID:23665939
NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801
G
Adora2a
adenosine A2a receptor
affects expression
EXP
Orphenadrine affects the expression of ADORA2A mRNA
CTD
PMID:23665939
NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
G
Adrb2
adrenoceptor beta 2
affects expression
EXP
Orphenadrine affects the expression of ADRB2 mRNA
CTD
PMID:23665939
NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
G
Ajuba
ajuba LIM protein
affects expression
EXP
Orphenadrine affects the expression of JUB mRNA
CTD
PMID:23665939
NCBI chr15:28,019,775...28,031,537
Ensembl chr15:28,019,778...28,030,021
G
Akr7a3
aldo-keto reductase family 7 member A3
affects expression
EXP
Orphenadrine affects the expression of AKR7A3 mRNA
CTD
PMID:23665939
NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
G
Aldh1a1
aldehyde dehydrogenase 1 family, member A1
affects expression
EXP
Orphenadrine affects the expression of ALDH1A1 mRNA
CTD
PMID:23665939
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
G
Alpl
alkaline phosphatase, biomineralization associated
affects expression
EXP
Orphenadrine affects the expression of ALPL mRNA
CTD
PMID:23665939
NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
G
Als2cl
ALS2 C-terminal like
affects expression
EXP
Orphenadrine affects the expression of ALS2CL mRNA
CTD
PMID:23665939
NCBI chr 8:110,863,753...110,884,434
Ensembl chr 8:110,864,975...110,884,419
G
Amigo3
adhesion molecule with Ig like domain 3
affects expression
EXP
Orphenadrine affects the expression of AMIGO3 mRNA
CTD
PMID:23665939
NCBI chr 8:108,741,899...108,743,425
Ensembl chr 8:108,693,060...108,744,555
G
Amotl2
angiomotin like 2
affects expression
EXP
Orphenadrine affects the expression of AMOTL2 mRNA
CTD
PMID:23665939
NCBI chr 8:103,303,368...103,319,161
Ensembl chr 8:103,302,992...103,318,910
G
Angptl4
angiopoietin-like 4
affects expression
EXP
Orphenadrine affects the expression of ANGPTL4 mRNA
CTD
PMID:23665939
NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
G
Angptl6
angiopoietin-like 6
affects expression
EXP
Orphenadrine affects the expression of ANGPTL6 mRNA
CTD
PMID:23665939
NCBI chr 8:19,413,617...19,419,925
Ensembl chr 8:19,413,619...19,419,925
G
Ankrd9
ankyrin repeat domain 9
affects expression
EXP
Orphenadrine affects the expression of ANKRD9 mRNA
CTD
PMID:23665939
NCBI chr 6:130,001,914...130,008,792
Ensembl chr 6:129,998,486...130,008,923
G
Ano1
anoctamin 1
affects expression
EXP
Orphenadrine affects the expression of ANO1 mRNA
CTD
PMID:23665939
NCBI chr 1:199,751,439...199,900,099
Ensembl chr 1:199,751,439...199,900,069
G
Anxa5
annexin A5
affects expression
EXP
Orphenadrine affects the expression of ANXA5 mRNA
CTD
PMID:23665939
NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369
G
App
amyloid beta precursor protein
affects expression
EXP
Orphenadrine affects the expression of APP mRNA
CTD
PMID:23665939
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
G
Aqp9
aquaporin 9
affects expression
EXP
Orphenadrine affects the expression of AQP9 mRNA
CTD
PMID:23665939
NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
G
Arhgap10
Rho GTPase activating protein 10
affects expression
EXP
Orphenadrine affects the expression of ARHGAP10 mRNA
CTD
PMID:23665939
NCBI chr19:30,448,572...30,710,315
Ensembl chr19:30,448,637...30,710,313
G
Arhgap22
Rho GTPase activating protein 22
affects expression
EXP
Orphenadrine affects the expression of ARHGAP22 mRNA
CTD
PMID:23665939
NCBI chr16:8,473,806...8,631,552
Ensembl chr16:8,476,306...8,631,548
G
Arhgef10
Rho guanine nucleotide exchange factor 10
affects expression
EXP
Orphenadrine affects the expression of ARHGEF10 mRNA
CTD
PMID:23665939
NCBI chr16:74,647,147...74,738,784
Ensembl chr16:74,647,153...74,738,173
G
Arhgef15
Rho guanine nucleotide exchange factor 15
affects expression
EXP
Orphenadrine affects the expression of ARHGEF15 mRNA
CTD
PMID:23665939
NCBI chr10:53,650,521...53,663,269
Ensembl chr10:53,650,553...53,663,913
G
Armcx1
armadillo repeat containing, X-linked 1
affects expression
EXP
Orphenadrine affects the expression of ARMCX1 mRNA
CTD
PMID:23665939
NCBI chr X:97,898,969...97,902,874
Ensembl chr X:97,898,883...97,903,299
G
Arrdc2
arrestin domain containing 2
affects expression
EXP
Orphenadrine affects the expression of ARRDC2 mRNA
CTD
PMID:23665939
NCBI chr16:18,601,897...18,606,029
Ensembl chr16:18,601,897...18,606,029
G
Atf3
activating transcription factor 3
affects expression
EXP
Orphenadrine affects the expression of ATF3 mRNA
CTD
PMID:23665939
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
G
Atp2b2
ATPase plasma membrane Ca2+ transporting 2
affects expression
EXP
Orphenadrine affects the expression of ATP2B2 mRNA
CTD
PMID:23665939
NCBI chr 4:146,894,602...147,208,060
Ensembl chr 4:146,896,332...147,140,665
G
Atrnl1
attractin like 1
affects expression
EXP
Orphenadrine affects the expression of ATRNL1 mRNA
CTD
PMID:23665939
NCBI chr 1:256,670,976...257,219,291
Ensembl chr 1:256,670,627...257,213,197
G
Azin2
antizyme inhibitor 2
affects expression
EXP
Orphenadrine affects the expression of AZIN2 mRNA
CTD
PMID:23665939
NCBI chr 5:141,281,310...141,310,415
Ensembl chr 5:141,281,249...141,310,397
G
B3gnt9
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9
affects expression
EXP
Orphenadrine affects the expression of B3GNT9 mRNA
CTD
PMID:23665939
NCBI chr19:33,129,740...33,134,048
Ensembl chr19:33,128,142...33,132,344
G
B4galt6
beta-1,4-galactosyltransferase 6
affects expression
EXP
Orphenadrine affects the expression of B4GALT6 mRNA
CTD
PMID:23665939
NCBI chr18:11,958,382...12,015,247
Ensembl chr18:11,958,390...12,015,247
G
Bambi
BMP and activin membrane-bound inhibitor
affects expression
EXP
Orphenadrine affects the expression of BAMBI mRNA
CTD
PMID:23665939
NCBI chr17:54,121,251...54,125,816
Ensembl chr17:54,121,255...54,126,060
G
Bbc3
Bcl-2 binding component 3
affects expression
EXP
Orphenadrine affects the expression of BBC3 mRNA
CTD
PMID:23665939
NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
G
Bcl6
BCL6, transcription repressor
affects expression
EXP
Orphenadrine affects the expression of BCL6 mRNA
CTD
PMID:23665939
NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
G
Bco2
beta-carotene oxygenase 2
affects expression
EXP
Orphenadrine affects the expression of BCO2 mRNA
CTD
PMID:23665939
NCBI chr 8:50,882,174...50,907,676
Ensembl chr 8:50,882,181...50,915,467
G
Bhlha15
basic helix-loop-helix family, member a15
affects expression
EXP
Orphenadrine affects the expression of BHLHA15 mRNA
CTD
PMID:23665939
NCBI chr12:10,420,465...10,424,641
Ensembl chr12:10,420,467...10,424,713
G
Bicc1
BicC family RNA binding protein 1
affects expression
EXP
Orphenadrine affects the expression of BICC1 mRNA
CTD
PMID:23665939
NCBI chr20:17,449,639...17,686,775
Ensembl chr20:17,449,560...17,686,776
G
Bmp4
bone morphogenetic protein 4
affects expression
EXP
Orphenadrine affects the expression of BMP4 mRNA
CTD
PMID:23665939
NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
G
Btbd7
BTB domain containing 7
affects expression
EXP
Orphenadrine affects the expression of BTBD7 mRNA
CTD
PMID:23665939
NCBI chr 6:121,920,365...122,010,114
Ensembl chr 6:121,923,023...121,972,405
G
C1h11orf24
similar to human chromosome 11 open reading frame 24
affects expression
EXP
Orphenadrine affects the expression of C1H11ORF24 mRNA
CTD
PMID:23665939
NCBI chr 1:200,945,188...200,953,953
Ensembl chr 1:200,945,180...200,962,585
G
C1qtnf2
C1q and TNF related 2
affects expression
EXP
Orphenadrine affects the expression of C1QTNF2 mRNA
CTD
PMID:23665939
NCBI chr10:27,941,948...27,958,926
Ensembl chr10:27,941,948...27,959,185
G
C8h15orf39
similar to human chromosome 15 open reading frame 39
affects expression
EXP
Orphenadrine affects the expression of C8H15ORF39 mRNA
CTD
PMID:23665939
NCBI chr 8:57,646,324...57,655,896
Ensembl chr 8:57,645,756...57,655,941
G
Calcrl
calcitonin receptor like receptor
affects expression
EXP
Orphenadrine affects the expression of CALCRL mRNA
CTD
PMID:23665939
NCBI chr 3:69,428,348...69,525,910
Ensembl chr 3:69,430,120...69,525,910
G
Car1
carbonic anhydrase 1
affects expression
EXP
Orphenadrine affects the expression of CA1 mRNA
CTD
PMID:23665939
NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
G
Car2
carbonic anhydrase 2
affects expression
EXP
Orphenadrine affects the expression of CA2 mRNA
CTD
PMID:23665939
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
G
Car3
carbonic anhydrase 3
affects expression
EXP
Orphenadrine affects the expression of CA3 mRNA
CTD
PMID:23665939
NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
G
Card19
caspase recruitment domain family, member 19
affects expression
EXP
Orphenadrine affects the expression of CARD19 mRNA
CTD
PMID:23665939
NCBI chr17:15,432,632...15,445,317
Ensembl chr17:15,432,612...15,445,318
G
Casp2
caspase 2
affects expression
EXP
Orphenadrine affects the expression of CASP2 mRNA
CTD
PMID:23665939
NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
G
Cblc
Cbl proto-oncogene C
affects expression
EXP
Orphenadrine affects the expression of CBLC mRNA
CTD
PMID:23665939
NCBI chr 1:79,439,975...79,456,755
Ensembl chr 1:79,439,977...79,456,755
G
Cbx4
chromobox 4
affects expression
EXP
Orphenadrine affects the expression of CBX4 mRNA
CTD
PMID:23665939
NCBI chr10:104,337,140...104,343,210
Ensembl chr10:104,336,876...104,356,706
G
Ccdc68
coiled-coil domain containing 68
affects expression
EXP
Orphenadrine affects the expression of CCDC68 mRNA
CTD
PMID:23665939
NCBI chr18:63,541,828...63,584,122
Ensembl chr18:63,541,896...63,584,119
G
Ccn1
cellular communication network factor 1
affects expression
EXP
Orphenadrine affects the expression of CCN1 mRNA
CTD
PMID:23665939
NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
G
Ccnd1
cyclin D1
multiple interactions
EXP
Orphenadrine promotes the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA]
CTD
PMID:23665939
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
G
Ccnd2
cyclin D2
affects expression
EXP
Orphenadrine affects the expression of CCND2 mRNA
CTD
PMID:23665939
NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
G
Cd24
CD24 molecule
affects expression
EXP
Orphenadrine affects the expression of CD24 mRNA
CTD
PMID:23665939
NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662
G
Cd276
Cd276 molecule
affects expression
EXP
Orphenadrine affects the expression of CD276 mRNA
CTD
PMID:23665939
NCBI chr 8:58,937,751...58,968,082
Ensembl chr 8:58,937,751...58,968,380
G
Cd36
CD36 molecule
affects expression
EXP
Orphenadrine affects the expression of CD36 mRNA
CTD
PMID:23665939
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
G
Cdc42ep1
CDC42 effector protein 1
affects expression
EXP
Orphenadrine affects the expression of CDC42EP1 mRNA
CTD
PMID:23665939
NCBI chr 7:110,395,287...110,403,203
Ensembl chr 7:110,395,332...110,403,200
G
Cdh3
cadherin 3
affects expression
EXP
Orphenadrine affects the expression of CDH3 mRNA
CTD
PMID:23665939
NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084
G
Cdr2
cerebellar degeneration-related protein 2
affects expression
EXP
Orphenadrine affects the expression of CDR2 mRNA
CTD
PMID:23665939
NCBI chr 1:175,502,837...175,527,746
Ensembl chr 1:175,502,838...175,537,472
G
Ces2h
carboxylesterase 2H
affects expression
EXP
Orphenadrine affects the expression of CES2 mRNA
CTD
PMID:23665939
NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
G
Cfap68
cilia and flagella associated protein 68
affects expression
EXP
Orphenadrine affects the expression of CFAP68 mRNA
CTD
PMID:23665939
NCBI chr 8:51,107,663...51,113,192
Ensembl chr 8:51,107,721...51,113,420
G
Cgref1
cell growth regulator with EF hand domain 1
affects expression
EXP
Orphenadrine affects the expression of CGREF1 mRNA
CTD
PMID:23665939
NCBI chr 6:25,431,846...25,443,853
Ensembl chr 6:25,431,799...25,443,852
G
Chmp4c
charged multivesicular body protein 4C
affects expression
EXP
Orphenadrine affects the expression of CHMP4C mRNA
CTD
PMID:23665939
NCBI chr 2:91,391,729...91,428,652
Ensembl chr 2:91,388,530...91,428,668
G
Cidea
cell death-inducing DFFA-like effector a
affects expression
EXP
Orphenadrine affects the expression of CIDEA mRNA
CTD
PMID:23665939
NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481
G
Cish
cytokine inducible SH2-containing protein
affects expression
EXP
Orphenadrine affects the expression of CISH mRNA
CTD
PMID:23665939
NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250
G
Clcf1
cardiotrophin-like cytokine factor 1
affects expression
EXP
Orphenadrine affects the expression of CLCF1 mRNA
CTD
PMID:23665939
NCBI chr 1:201,507,763...201,517,607
Ensembl chr 1:201,507,859...201,517,605
G
Cldn23
claudin 23
affects expression
EXP
Orphenadrine affects the expression of CLDN23 mRNA
CTD
PMID:23665939
NCBI chr16:56,413,677...56,415,401
Ensembl chr16:56,413,381...56,415,523
G
Cndp1
carnosine dipeptidase 1
affects expression
EXP
Orphenadrine affects the expression of CNDP1 mRNA
CTD
PMID:23665939
NCBI chr18:77,984,886...78,030,837
Ensembl chr18:77,984,907...78,007,765
G
Col4a3
collagen type IV alpha 3 chain
affects expression
EXP
Orphenadrine affects the expression of COL4A3 mRNA
CTD
PMID:23665939
NCBI chr 9:83,875,849...84,004,955
Ensembl chr 9:83,875,561...84,001,895
G
Cpt1b
carnitine palmitoyltransferase 1B
affects expression
EXP
Orphenadrine affects the expression of CPT1B mRNA
CTD
PMID:23665939
NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404
G
Crat
carnitine O-acetyltransferase
affects expression
EXP
Orphenadrine affects the expression of CRAT mRNA
CTD
PMID:23665939
NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255
G
Crlf2
cytokine receptor-like factor 2
affects expression
EXP
Orphenadrine affects the expression of CRLF2 mRNA
CTD
PMID:23665939
NCBI chr14:103,943...108,643
Ensembl chr14:103,939...108,642
G
Cryab
crystallin, alpha B
affects expression
EXP
Orphenadrine affects the expression of CRYAB mRNA
CTD
PMID:23665939
NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
G
Cryl1
crystallin, lambda 1
affects expression
EXP
Orphenadrine affects the expression of CRYL1 mRNA
CTD
PMID:23665939
NCBI chr15:31,427,011...31,545,997
Ensembl chr15:31,427,054...31,545,997
G
Csmd1
CUB and Sushi multiple domains 1
affects expression
EXP
Orphenadrine affects the expression of CSMD1 mRNA
CTD
PMID:23665939
NCBI chr16:72,218,189...73,818,380
Ensembl chr16:72,218,503...73,817,614
G
Csrnp1
cysteine and serine rich nuclear protein 1
affects expression
EXP
Orphenadrine affects the expression of CSRNP1 mRNA
CTD
PMID:23665939
NCBI chr 8:119,704,712...119,717,767
Ensembl chr 8:119,704,713...119,718,183
G
Cst9l
cystatin 9-like
affects expression
EXP
Orphenadrine affects the expression of CST9L mRNA
CTD
PMID:23665939
NCBI chr 3:136,288,093...136,290,906
Ensembl chr 3:136,288,093...136,290,906
G
Ctps1
CTP synthase 1
affects expression
EXP
Orphenadrine affects the expression of CTPS1 mRNA
CTD
PMID:23665939
NCBI chr 5:134,125,022...134,154,155
Ensembl chr 5:134,125,025...134,154,180
G
Ctrb1
chymotrypsinogen B1
affects expression
EXP
Orphenadrine affects the expression of CTRB mRNA
CTD
PMID:23665939
NCBI chr19:39,652,931...39,657,689
Ensembl chr19:39,652,933...39,657,688
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions affects expression
EXP
[Orphenadrine co-treated with Diethylnitrosamine] results in increased expression of CYP1A1 mRNA Orphenadrine affects the expression of CYP1A1 mRNA
CTD
PMID:23665939 PMID:23665940
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions decreases activity
ISO EXP
Orphenadrine inhibits the reaction [CYP1A2 protein results in decreased ethylation of 7-ethoxy-4-trifluoromethylcoumarin]; Orphenadrine inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin] Orphenadrine results in decreased activity of CYP1A2 protein Orphenadrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
CTD
PMID:9241656 PMID:18493746
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
G
Cyp2b15
cytochrome P450, family 2, subfamily b, polypeptide 15
affects expression
EXP
Orphenadrine affects the expression of CYP2B15 mRNA
CTD
PMID:23665939
NCBI chr 1:82,094,188...82,106,492
Ensembl chr 1:82,094,180...82,106,492
G
Cyp2b2
cytochrome P450, family 2, subfamily b, polypeptide 2
affects expression multiple interactions
EXP
Orphenadrine affects the expression of CYP2B2 mRNA [Orphenadrine co-treated with Phenobarbital] affects the expression of CYP2B2 mRNA
CTD
PMID:23665939 PMID:23665940
NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
G
Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
multiple interactions decreases activity
ISO
Orphenadrine inhibits the reaction [CYP2B6 protein results in decreased ethylation of 7-ethoxy-4-trifluoromethylcoumarin]; Orphenadrine inhibits the reaction [CYP2B6 protein results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin] Orphenadrine results in decreased activity of CYP2B6 protein
CTD
PMID:9241656 PMID:12464242 PMID:15306208
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
G
Cyp2c12
cytochrome P450, family 2, subfamily c, polypeptide 12
affects expression
EXP
Orphenadrine affects the expression of CYP2C12 mRNA
CTD
PMID:23665939
NCBI chr 1:238,699,859...238,757,011
Ensembl chr 1:238,699,854...238,757,019
G
Cyp2c24
cytochrome P450, family 2, subfamily c, polypeptide 24
affects expression
EXP
Orphenadrine affects the expression of CYP2C24 mRNA
CTD
PMID:23665939
NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
multiple interactions decreases activity
ISO
Orphenadrine inhibits the reaction [CYP2E1 protein results in decreased ethylation of 7-ethoxy-4-trifluoromethylcoumarin]; Orphenadrine inhibits the reaction [CYP2E1 protein results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin] Orphenadrine results in decreased activity of CYP2E1 protein
CTD
PMID:9241656
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
G
Cyp3a62
cytochrome P450, family 3, subfamily a, polypeptide 62
affects expression
EXP
Orphenadrine affects the expression of CYP3A62 mRNA
CTD
PMID:23665939
NCBI chr12:16,397,998...16,433,833
Ensembl chr12:16,397,998...16,433,833
G
Cyp4a1
cytochrome P450, family 4, subfamily a, polypeptide 1
affects expression
EXP
Orphenadrine affects the expression of CYP4A1 mRNA
CTD
PMID:23665939
NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
G
Cyp4a8
cytochrome P450, family 4, subfamily a, polypeptide 8
affects expression
EXP
Orphenadrine affects the expression of CYP4A8 mRNA
CTD
PMID:23665939
NCBI chr 5:128,702,130...128,733,476
Ensembl chr 5:128,702,131...128,733,476
G
Cyp4b1
cytochrome P450, family 4, subfamily b, polypeptide 1
affects expression
EXP
Orphenadrine affects the expression of CYP4B1 mRNA
CTD
PMID:23665939
NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348
G
Cyp4f5
cytochrome P450, family 4, subfamily f, polypeptide 5
affects expression
EXP
Orphenadrine affects the expression of CYP4F5 mRNA
CTD
PMID:23665939
NCBI chr 7:11,544,040...11,558,982
Ensembl chr 7:11,544,082...11,558,978
G
Cyp7a1
cytochrome P450 family 7 subfamily A member 1
affects expression
EXP
Orphenadrine affects the expression of CYP7A1 mRNA
CTD
PMID:23665939
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
G
Cyp8b1
cytochrome P450 family 8 subfamily B member 1
affects expression
EXP
Orphenadrine affects the expression of CYP8B1 mRNA
CTD
PMID:23665939
NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
G
Cystm1
cysteine-rich transmembrane module containing 1
affects expression
EXP
Orphenadrine affects the expression of CYSTM1 mRNA
CTD
PMID:23665939
NCBI chr18:27,945,862...28,013,509
Ensembl chr18:27,951,653...28,013,510
G
Cyyr1
cysteine and tyrosine rich 1
affects expression
EXP
Orphenadrine affects the expression of CYYR1 mRNA
CTD
PMID:23665939
NCBI chr11:24,557,620...24,664,007
Ensembl chr11:24,515,316...24,663,961
G
Dact2
dishevelled-binding antagonist of beta-catenin 2
affects expression
EXP
Orphenadrine affects the expression of DACT2 mRNA
CTD
PMID:23665939
NCBI chr 1:55,181,023...55,191,026
Ensembl chr 1:55,181,024...55,191,096
G
Defb36
defensin beta 36
affects expression
EXP
Orphenadrine affects the expression of DEFB36 mRNA
CTD
PMID:23665939
NCBI chr 3:141,078,001...141,086,832
Ensembl chr 3:141,086,058...141,086,728
G
Dip2a
disco-interacting protein 2 homolog A
affects expression
EXP
Orphenadrine affects the expression of DIP2A mRNA
CTD
PMID:23665939
NCBI chr20:12,284,566...12,371,068
Ensembl chr20:12,284,654...12,370,217
G
Dll1
delta like canonical Notch ligand 1
affects expression
EXP
Orphenadrine affects the expression of DLL1 mRNA
CTD
PMID:23665939
NCBI chr 1:56,312,062...56,320,177
Ensembl chr 1:56,312,066...56,320,179
G
Dnhd1
dynein heavy chain domain 1
affects expression
EXP
Orphenadrine affects the expression of DNHD1 mRNA
CTD
PMID:23665939
NCBI chr 1:159,990,785...160,077,990
Ensembl chr 1:159,990,438...160,074,858
G
Dpp6
dipeptidyl peptidase like 6
affects expression
EXP
Orphenadrine affects the expression of DPP6 mRNA
CTD
PMID:23665939
NCBI chr 4:7,589,386...8,508,666
Ensembl chr 4:7,591,009...8,508,532
G
Dppa3l2
developmental pluripotency associated 3 like 2
affects expression
EXP
Orphenadrine affects the expression of DPPA3L2 mRNA
CTD
PMID:23665939
NCBI chr17:2,886,537...2,887,217
G
Dram1
DNA-damage regulated autophagy modulator 1
affects expression
EXP
Orphenadrine affects the expression of DRAM1 mRNA
CTD
PMID:23665939
NCBI chr 7:22,742,794...22,776,888
Ensembl chr 7:22,742,849...22,776,765
G
Dusp1
dual specificity phosphatase 1
affects expression
EXP
Orphenadrine affects the expression of DUSP1 mRNA
CTD
PMID:23665939
NCBI chr10:16,680,478...16,683,275
G
Dusp10
dual specificity phosphatase 10
affects expression
EXP
Orphenadrine affects the expression of DUSP10 mRNA
CTD
PMID:23665939
NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716
G
Dusp13b
dual specificity phosphatase 13B
affects expression
EXP
Orphenadrine affects the expression of DUSP13B mRNA
CTD
PMID:23665939
NCBI chr15:2,567,432...2,575,105
Ensembl chr15:2,533,547...2,575,539
G
Dusp16
dual specificity phosphatase 16
affects expression
EXP
Orphenadrine affects the expression of DUSP16 mRNA
CTD
PMID:23665939
NCBI chr 4:167,546,780...167,630,173
Ensembl chr 4:167,548,155...167,629,980
G
Dusp8
dual specificity phosphatase 8
affects expression
EXP
Orphenadrine affects the expression of DUSP8 mRNA
CTD
PMID:23665939
NCBI chr 1:197,167,392...197,184,285
Ensembl chr 1:197,169,422...197,182,921
G
Eeig1
estrogen-induced osteoclastogenesis regulator 1
affects expression
EXP
Orphenadrine affects the expression of EEIG1 mRNA
CTD
PMID:23665939
NCBI chr 3:15,822,441...15,854,651
Ensembl chr 3:15,823,144...15,854,643
G
Eeig2
EEIG family member 2
affects expression
EXP
Orphenadrine affects the expression of EEIG2 mRNA
CTD
PMID:23665939
NCBI chr 2:196,608,499...196,663,371
Ensembl chr 2:196,608,499...196,663,371
G
Efemp1
EGF containing fibulin extracellular matrix protein 1
affects expression
EXP
Orphenadrine affects the expression of EFEMP1 mRNA
CTD
PMID:23665939
NCBI chr14:102,610,813...102,690,027
Ensembl chr14:102,610,908...102,690,018
G
Egln3
egl-9 family hypoxia-inducible factor 3
affects expression
EXP
Orphenadrine affects the expression of EGLN3 mRNA
CTD
PMID:23665939
NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766
G
Egr1
early growth response 1
affects expression
EXP
Orphenadrine affects the expression of EGR1 mRNA
CTD
PMID:23665939
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
G
Emilin1
elastin microfibril interfacer 1
affects expression
EXP
Orphenadrine affects the expression of EMILIN1 mRNA
CTD
PMID:23665939
NCBI chr 6:25,455,974...25,463,713
Ensembl chr 6:25,445,298...25,463,698
G
Epha2
Eph receptor A2
affects expression
EXP
Orphenadrine affects the expression of EPHA2 mRNA
CTD
PMID:23665939
NCBI chr 5:153,605,644...153,634,115
Ensembl chr 5:153,605,644...153,634,117
G
Ephb4
EPH receptor B4
affects expression
EXP
Orphenadrine affects the expression of EPHB4 mRNA
CTD
PMID:23665939
NCBI chr12:19,326,411...19,351,667
Ensembl chr12:19,326,427...19,351,314
G
Eri2
ERI1 exoribonuclease family member 2
affects expression
EXP
Orphenadrine affects the expression of ERI2 mRNA
CTD
PMID:23665939
NCBI chr 1:174,140,831...174,168,757
Ensembl chr 1:174,141,993...174,168,665
G
F8
coagulation factor VIII
affects expression
EXP
Orphenadrine affects the expression of F8 mRNA
CTD
PMID:23665939
NCBI chr18:140,848...172,330
Ensembl chr18:140,955...171,857
G
Fam89a
family with sequence similarity 89, member A
affects expression
EXP
Orphenadrine affects the expression of FAM89A mRNA
CTD
PMID:23665939
NCBI chr19:52,710,002...52,722,630
Ensembl chr19:52,710,019...52,722,631
G
Fbxo27
F-box protein 27
affects expression
EXP
Orphenadrine affects the expression of FBXO27 mRNA
CTD
PMID:23665939
NCBI chr 1:83,965,426...83,987,781
Ensembl chr 1:83,965,986...83,987,778
G
Fer1l5
fer-1-like family member 5
affects expression
EXP
Orphenadrine affects the expression of FER1L5 mRNA
CTD
PMID:23665939
NCBI chr 9:38,605,835...38,661,869
Ensembl chr 9:38,607,843...38,660,425
G
Fgd5
FYVE, RhoGEF and PH domain containing 5
affects expression
EXP
Orphenadrine affects the expression of FGD5 mRNA
CTD
PMID:23665939
NCBI chr 4:124,497,061...124,594,564
Ensembl chr 4:124,497,068...124,594,563
G
Flt1
Fms related receptor tyrosine kinase 1
affects expression
EXP
Orphenadrine affects the expression of FLT1 mRNA
CTD
PMID:23665939
NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
G
Flt4
Fms related receptor tyrosine kinase 4
affects expression
EXP
Orphenadrine affects the expression of FLT4 mRNA
CTD
PMID:23665939
NCBI chr10:33,913,725...33,954,770
Ensembl chr10:33,913,608...33,954,770
G
Fmo1
flavin containing dimethylaniline monoxygenase 1
affects expression
EXP
Orphenadrine affects the expression of FMO1 mRNA
CTD
PMID:23665939
NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
G
Fndc5
fibronectin type III domain containing 5
affects expression
EXP
Orphenadrine affects the expression of FNDC5 mRNA
CTD
PMID:23665939
NCBI chr 5:141,481,593...141,491,257
Ensembl chr 5:141,481,590...141,490,731
G
Fst
follistatin
affects expression
EXP
Orphenadrine affects the expression of FST mRNA
CTD
PMID:23665939
NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571
G
Gadd45g
growth arrest and DNA-damage-inducible, gamma
affects expression
EXP
Orphenadrine affects the expression of GADD45G mRNA
CTD
PMID:23665939
NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610
G
Gdf11
growth differentiation factor 11
affects expression
EXP
Orphenadrine affects the expression of GDF11 mRNA
CTD
PMID:23665939
NCBI chr 7:1,311,732...1,325,211
Ensembl chr 7:1,311,732...1,320,725
G
Ggt1
gamma-glutamyltransferase 1
affects expression
EXP
Orphenadrine affects the expression of GGT1 mRNA
CTD
PMID:23665939
NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
G
Gimd1
GIMAP family P-loop NTPase domain containing 1
affects expression
EXP
Orphenadrine affects the expression of GIMD1 mRNA
CTD
PMID:23665939
NCBI chr 2:221,103,878...221,138,559
Ensembl chr 2:221,103,878...221,138,553
G
Gipc2
GIPC PDZ domain containing family, member 2
affects expression
EXP
Orphenadrine affects the expression of GIPC2 mRNA
CTD
PMID:23665939
NCBI chr 2:241,030,764...241,110,236
Ensembl chr 2:241,030,770...241,110,236
G
Gmip
Gem-interacting protein
affects expression
EXP
Orphenadrine affects the expression of GMIP mRNA
CTD
PMID:23665939
NCBI chr16:19,600,723...19,614,459
Ensembl chr16:19,600,723...19,614,027
G
Gna14
G protein subunit alpha 14
affects expression
EXP
Orphenadrine affects the expression of GNA14 mRNA
CTD
PMID:23665939
NCBI chr 1:213,714,993...213,900,083
Ensembl chr 1:213,716,020...213,897,423
G
Gnai1
G protein subunit alpha i1
affects expression
EXP
Orphenadrine affects the expression of GNAI1 mRNA
CTD
PMID:23665939
NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417
G
Gpat3
glycerol-3-phosphate acyltransferase 3
affects expression
EXP
Orphenadrine affects the expression of GPAT3 mRNA
CTD
PMID:23665939
NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490
G
Gpr17
G protein-coupled receptor 17
affects expression
EXP
Orphenadrine affects the expression of GPR17 mRNA
CTD
PMID:23665939
NCBI chr18:23,576,232...23,583,153
Ensembl chr18:23,577,242...23,582,966
G
Gpx2
glutathione peroxidase 2
affects expression multiple interactions
EXP
Orphenadrine affects the expression of GPX2 mRNA [Orphenadrine co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA; [Phenobarbital co-treated with Orphenadrine] affects the expression of GPX2 mRNA
CTD
PMID:23665939 PMID:23665940
NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
G
Gria3
glutamate ionotropic receptor AMPA type subunit 3
affects expression
EXP
Orphenadrine affects the expression of GRIA3 mRNA
CTD
PMID:23665939
NCBI chr X:120,238,515...120,504,106
Ensembl chr X:120,238,534...120,504,096
G
Grik5
glutamate ionotropic receptor kainate type subunit 5
affects expression
EXP
Orphenadrine affects the expression of GRIK5 mRNA
CTD
PMID:23665939
NCBI chr 1:80,605,878...80,667,896
Ensembl chr 1:80,605,892...80,667,125
G
Gse1
Gse1 coiled-coil protein
affects expression
EXP
Orphenadrine affects the expression of GSE1 mRNA
CTD
PMID:23665939
NCBI chr19:48,274,164...48,629,456
Ensembl chr19:48,274,127...48,629,458
G
Gstm4
glutathione S-transferase mu 4
affects expression
EXP
Orphenadrine affects the expression of GSTM4 mRNA
CTD
PMID:23665939
NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323
G
Gstm5
glutathione S-transferase, mu 5
multiple interactions affects expression
EXP
[Orphenadrine co-treated with Diethylnitrosamine] results in increased expression of GSTM3 mRNA; [Phenobarbital co-treated with Orphenadrine] affects the expression of GSTM3 mRNA Orphenadrine affects the expression of GSTM3 mRNA
CTD
PMID:23665939 PMID:23665940
NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553
G
Gstp1
glutathione S-transferase pi 1
affects expression
EXP
Orphenadrine affects the expression of GSTP1 mRNA
CTD
PMID:23665939
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
G
Hal
histidine ammonia lyase
affects expression
EXP
Orphenadrine affects the expression of HAL mRNA
CTD
PMID:23665939
NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701
G
Hebp2
heme binding protein 2
affects expression
EXP
Orphenadrine affects the expression of HEBP2 mRNA
CTD
PMID:23665939
NCBI chr 1:13,194,982...13,201,777
Ensembl chr 1:13,194,982...13,201,777
G
Hes1
hes family bHLH transcription factor 1
affects expression
EXP
Orphenadrine affects the expression of HES1 mRNA
CTD
PMID:23665939
NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
G
Hgf
hepatocyte growth factor
affects expression
EXP
Orphenadrine affects the expression of HGF mRNA
CTD
PMID:23665939
NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
G
Hid1
HID1 domain containing
affects expression
EXP
Orphenadrine affects the expression of HID1 mRNA
CTD
PMID:23665939
NCBI chr10:100,589,555...100,610,050
Ensembl chr10:100,589,555...100,610,041
G
Hspa1a
heat shock protein family A (Hsp70) member 1A
affects expression
EXP
Orphenadrine affects the expression of HSPA1A mRNA
CTD
PMID:23665939
NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
G
Hspa1b
heat shock protein family A (Hsp70) member 1B
affects expression
EXP
Orphenadrine affects the expression of HSPA1B mRNA
CTD
PMID:23665939
NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240 Ensembl chr20:3,856,006...3,873,240
G
Hycc1
hyccin PI4KA lipid kinase complex subunit 1
affects expression
EXP
Orphenadrine affects the expression of HYCC1 mRNA
CTD
PMID:23665939
NCBI chr 4:11,132,224...11,239,120
Ensembl chr 4:11,132,385...11,239,113
G
Id1
inhibitor of DNA binding 1
affects expression
EXP
Orphenadrine affects the expression of ID1 mRNA
CTD
PMID:23665939
NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
G
Id3
inhibitor of DNA binding 3
affects expression
EXP
Orphenadrine affects the expression of ID3 mRNA
CTD
PMID:23665939
NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349
G
Ido2
indoleamine 2,3-dioxygenase 2
affects expression
EXP
Orphenadrine affects the expression of IDO2 mRNA
CTD
PMID:23665939
NCBI chr16:67,459,158...67,498,052
Ensembl chr16:67,459,190...67,496,324
G
Ier5
immediate early response 5
affects expression
EXP
Orphenadrine affects the expression of IER5 mRNA
CTD
PMID:23665939
NCBI chr13:67,270,134...67,272,226
Ensembl chr13:67,270,135...67,272,227
G
Igfbp1
insulin-like growth factor binding protein 1
affects expression
EXP
Orphenadrine affects the expression of IGFBP1 mRNA
CTD
PMID:23665939
NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
G
Ihh
Indian hedgehog signaling molecule
affects expression
EXP
Orphenadrine affects the expression of IHH mRNA
CTD
PMID:23665939
NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532
G
Ikbkg
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
affects expression
EXP
Orphenadrine affects the expression of IKBKG mRNA
CTD
PMID:23665939
NCBI chr X:152,216,485...152,241,476
Ensembl chr X:152,216,596...152,239,499
G
Il17rb
interleukin 17 receptor B
affects expression
EXP
Orphenadrine affects the expression of IL17RB mRNA
CTD
PMID:23665939
NCBI chr16:5,180,431...5,194,125
Ensembl chr16:5,180,432...5,194,125
G
Il33
interleukin 33
affects expression
EXP
Orphenadrine affects the expression of IL33 mRNA
CTD
PMID:23665939
NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
G
Inf2
inverted formin 2
affects expression
EXP
Orphenadrine affects the expression of INF2 mRNA
CTD
PMID:23665939
NCBI chr 6:131,649,162...131,675,944
Ensembl chr 6:131,649,211...131,675,941
G
Ip6k2
inositol hexakisphosphate kinase 2
affects expression
EXP
Orphenadrine affects the expression of IP6K2 mRNA
CTD
PMID:23665939
NCBI chr 8:109,483,843...109,510,172
Ensembl chr 8:109,484,310...109,510,166
G
Irf7
interferon regulatory factor 7
affects expression
EXP
Orphenadrine affects the expression of IRF7 mRNA
CTD
PMID:23665939
NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
G
Irx1
iroquois homeobox 1
affects expression
EXP
Orphenadrine affects the expression of IRX1 mRNA
CTD
PMID:23665939
NCBI chr 1:31,294,615...31,300,444
Ensembl chr 1:31,294,615...31,300,444
G
Isg15
ISG15 ubiquitin-like modifier
affects expression
EXP
Orphenadrine affects the expression of ISG15 mRNA
CTD
PMID:23665939
NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435
G
Itgb3
integrin subunit beta 3
affects expression
EXP
Orphenadrine affects the expression of ITGB3 mRNA
CTD
PMID:23665939
NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
G
Jun
Jun proto-oncogene, AP-1 transcription factor subunit
affects expression
EXP
Orphenadrine affects the expression of JUN mRNA
CTD
PMID:23665939
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
G
Junb
JunB proto-oncogene, AP-1 transcription factor subunit
affects expression
EXP
Orphenadrine affects the expression of JUNB mRNA
CTD
PMID:23665939
NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
G
Ka11
type I keratin KA11
affects expression
EXP
Orphenadrine affects the expression of KA11 mRNA
CTD
PMID:23665939
NCBI chr10:85,161,424...85,164,737
Ensembl chr10:85,066,802...85,171,799
G
Kank2
KN motif and ankyrin repeat domains 2
affects expression
EXP
Orphenadrine affects the expression of KANK2 mRNA
CTD
PMID:23665939
NCBI chr 8:20,311,676...20,341,107
Ensembl chr 8:20,311,676...20,340,900
G
Kcnj15
potassium inwardly-rectifying channel, subfamily J, member 15
affects expression
EXP
Orphenadrine affects the expression of KCNJ15 mRNA
CTD
PMID:23665939
NCBI chr11:34,577,397...34,621,725
Ensembl chr11:34,577,363...34,621,952
G
Kcnk5
potassium two pore domain channel subfamily K member 5
affects expression
EXP
Orphenadrine affects the expression of KCNK5 mRNA
CTD
PMID:23665939
NCBI chr15:4,122,442...4,164,718
Ensembl chr15:4,122,442...4,164,718
G
Klf10
KLF transcription factor 10
affects expression
EXP
Orphenadrine affects the expression of KLF10 mRNA
CTD
PMID:23665939
NCBI chr 7:69,467,658...69,473,726
Ensembl chr 7:69,465,619...69,473,994
G
Klhl21
kelch-like family member 21
affects expression
EXP
Orphenadrine affects the expression of KLHL21 mRNA
CTD
PMID:23665939
NCBI chr 5:162,514,888...162,523,545
Ensembl chr 5:162,514,765...162,523,545
G
Kmo
kynurenine 3-monooxygenase
affects expression
EXP
Orphenadrine affects the expression of KMO mRNA
CTD
PMID:23665939
NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881
G
Krt10
keratin 10
affects expression
EXP
Orphenadrine affects the expression of KRT10 mRNA
CTD
PMID:23665939
NCBI chr10:84,338,695...84,343,279
Ensembl chr10:84,338,706...84,343,701
G
Krt8
keratin 8
affects expression
EXP
Orphenadrine affects the expression of KRT8 mRNA
CTD
PMID:23665939
NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728
G
Lag3
lymphocyte activating 3
affects expression
EXP
Orphenadrine affects the expression of LAG3 mRNA
CTD
PMID:23665939
NCBI chr 4:157,712,665...157,722,229
Ensembl chr 4:157,712,667...157,720,404
G
Lekr1
leucine, glutamate and lysine rich 1
affects expression
EXP
Orphenadrine affects the expression of LEKR1 mRNA
CTD
PMID:23665939
NCBI chr 2:149,889,615...150,061,167
Ensembl chr 2:149,891,106...150,060,469
G
Lgals2
galectin 2
affects expression
EXP
Orphenadrine affects the expression of LGALS2 mRNA
CTD
PMID:23665939
NCBI chr 7:110,403,171...110,410,046
Ensembl chr 7:110,403,173...110,404,802
G
Lhx8
LIM homeobox 8
affects expression
EXP
Orphenadrine affects the expression of LHX8 mRNA
CTD
PMID:23665939
NCBI chr 2:243,244,958...243,269,624
Ensembl chr 2:243,244,961...243,269,416
G
Lilrb4
leukocyte immunoglobulin like receptor B4
affects expression
EXP
Orphenadrine affects the expression of LILRB4 mRNA
CTD
PMID:23665939
NCBI chr 1:69,805,020...69,810,628
Ensembl chr 1:69,805,250...69,810,660
G
Lin7a
lin-7 homolog A, crumbs cell polarity complex component
affects expression
EXP
Orphenadrine affects the expression of LIN7A mRNA
CTD
PMID:23665939
NCBI chr 7:42,586,704...42,742,609
Ensembl chr 7:42,586,719...42,730,550
G
Lmod2
leiomodin 2
affects expression
EXP
Orphenadrine affects the expression of LMOD2 mRNA
CTD
PMID:23665939
NCBI chr 4:53,067,428...53,075,124
Ensembl chr 4:53,067,428...53,075,120
G
Loxl4
lysyl oxidase-like 4
affects expression
EXP
Orphenadrine affects the expression of LOXL4 mRNA
CTD
PMID:23665939
NCBI chr 1:241,396,183...241,416,385
Ensembl chr 1:241,397,983...241,416,322
G
Lpcat4
lysophosphatidylcholine acyltransferase 4
affects expression
EXP
Orphenadrine affects the expression of LPCAT4 mRNA
CTD
PMID:23665939
NCBI chr 3:99,044,729...99,052,963
Ensembl chr 3:99,044,729...99,052,875
G
Lpin2
lipin 2
affects expression
EXP
Orphenadrine affects the expression of LPIN2 mRNA
CTD
PMID:23665939
NCBI chr 9:111,083,378...111,158,193
Ensembl chr 9:111,083,745...111,158,193
G
Lpl
lipoprotein lipase
affects expression
EXP
Orphenadrine affects the expression of LPL mRNA
CTD
PMID:23665939
NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
G
Lrrn4
leucine rich repeat neuronal 4
affects expression
EXP
Orphenadrine affects the expression of LRRN4 mRNA
CTD
PMID:23665939
NCBI chr 3:120,138,093...120,150,877
Ensembl chr 3:120,139,410...120,150,831
G
Ltc4s
leukotriene C4 synthase
affects expression
EXP
Orphenadrine affects the expression of LTC4S mRNA
CTD
PMID:23665939
NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651
G
Mafb
MAF bZIP transcription factor B
affects expression
EXP
Orphenadrine affects the expression of MAFB mRNA
CTD
PMID:23665939
NCBI chr 3:148,998,111...149,000,031
Ensembl chr 3:148,998,122...149,000,031
G
Magee1
MAGE family member E1
affects expression
EXP
Orphenadrine affects the expression of MAGEE1 mRNA
CTD
PMID:23665939
NCBI chr X:70,189,242...70,192,789
Ensembl chr X:70,189,187...70,192,810
G
Map1s
microtubule-associated protein 1S
affects expression
EXP
Orphenadrine affects the expression of MAP1S mRNA
CTD
PMID:23665939
NCBI chr16:18,516,759...18,527,777
Ensembl chr16:18,517,574...18,527,988
G
Map4k2
mitogen activated protein kinase kinase kinase kinase 2
affects expression
EXP
Orphenadrine affects the expression of MAP4K2 mRNA
CTD
PMID:23665939
NCBI chr 1:203,645,098...203,660,782
Ensembl chr 1:203,645,153...203,660,331
G
Map4k4
mitogen-activated protein kinase kinase kinase kinase 4
affects expression
EXP
Orphenadrine affects the expression of MAP4K4 mRNA
CTD
PMID:23665939
NCBI chr 9:42,200,708...42,326,708
Ensembl chr 9:42,200,278...42,326,698
G
Mapk12
mitogen-activated protein kinase 12
affects expression
EXP
Orphenadrine affects the expression of MAPK12 mRNA
CTD
PMID:23665939
NCBI chr 7:120,206,005...120,216,711
Ensembl chr 7:120,206,271...120,216,664
G
Matn4
matrilin 4
affects expression
EXP
Orphenadrine affects the expression of MATN4 mRNA
CTD
PMID:23665939
NCBI chr 3:153,120,605...153,135,628
Ensembl chr 3:153,120,632...153,135,865
G
Mcam
melanoma cell adhesion molecule
affects expression
EXP
Orphenadrine affects the expression of MCAM mRNA
CTD
PMID:23665939
NCBI chr 8:44,479,391...44,487,575
Ensembl chr 8:44,479,376...44,487,571
G
Metap1d
methionyl aminopeptidase type 1D (mitochondrial)
affects expression
EXP
Orphenadrine affects the expression of METAP1D mRNA
CTD
PMID:23665939
NCBI chr 3:56,279,471...56,354,518
Ensembl chr 3:56,279,493...56,351,981
G
Mex3b
mex-3 RNA binding family member B
affects expression
EXP
Orphenadrine affects the expression of MEX3B mRNA
CTD
PMID:23665939
NCBI chr 1:136,855,130...136,859,365
Ensembl chr 1:136,855,130...136,859,354
G
Mex3d
mex-3 RNA binding family member D
affects expression
EXP
Orphenadrine affects the expression of MEX3D mRNA
CTD
PMID:23665939
NCBI chr 7:9,325,575...9,332,705
Ensembl chr 7:9,325,488...9,332,096
G
Mfge8
milk fat globule EGF and factor V/VIII domain containing
affects expression
EXP
Orphenadrine affects the expression of MFGE8 mRNA
CTD
PMID:23665939
NCBI chr 1:133,064,665...133,080,069
Ensembl chr 1:133,064,665...133,080,073
G
Mid1
midline 1
affects expression
EXP
Orphenadrine affects the expression of MID1 mRNA
CTD
PMID:23665939
NCBI chr X:24,116,674...24,491,205
Ensembl chr X:24,120,293...24,248,353
G
Mid1ip1
MID1 interacting protein 1
affects expression
EXP
Orphenadrine affects the expression of MID1IP1 mRNA
CTD
PMID:23665939
NCBI chr X:12,060,993...12,063,318
Ensembl chr X:12,060,883...12,065,774
G
Midn
midnolin
affects expression
EXP
Orphenadrine affects the expression of MIDN mRNA
CTD
PMID:23665939
NCBI chr 7:9,548,100...9,559,605
Ensembl chr 7:9,549,650...9,559,752
G
Mknk2
MAPK interacting serine/threonine kinase 2
affects expression
EXP
Orphenadrine affects the expression of MKNK2 mRNA
CTD
PMID:23665939
NCBI chr 7:9,039,771...9,050,832
Ensembl chr 7:9,039,728...9,050,827
G
Mlxip
MLX interacting protein
affects expression
EXP
Orphenadrine affects the expression of MLXIP mRNA
CTD
PMID:23665939
NCBI chr12:33,128,524...33,192,300
Ensembl chr12:33,128,520...33,192,374
G
Mmd
monocyte to macrophage differentiation-associated
affects expression
EXP
Orphenadrine affects the expression of MMD mRNA
CTD
PMID:23665939
NCBI chr10:75,073,278...75,101,528
Ensembl chr10:75,073,365...75,101,528
G
Mmp12
matrix metallopeptidase 12
affects expression
EXP
Orphenadrine affects the expression of MMP12 mRNA
CTD
PMID:23665939
NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611
G
Mmp15
matrix metallopeptidase 15
affects expression
EXP
Orphenadrine affects the expression of MMP15 mRNA
CTD
PMID:23665939
NCBI chr19:9,663,449...9,684,943
Ensembl chr19:9,663,449...9,684,943
G
Mras
muscle RAS oncogene homolog
affects expression
EXP
Orphenadrine affects the expression of MRAS mRNA
CTD
PMID:23665939
NCBI chr 8:99,944,036...100,006,771
Ensembl chr 8:99,944,036...99,996,408
G
Mroh2a
maestro heat-like repeat family member 2A
affects expression
EXP
Orphenadrine affects the expression of MROH2A mRNA
CTD
PMID:23665939
NCBI chr 9:88,814,515...88,862,346
Ensembl chr 9:88,814,197...88,852,607
G
Mst1r
macrophage stimulating 1 receptor
affects expression
EXP
Orphenadrine affects the expression of MST1R mRNA
CTD
PMID:23665939
NCBI chr 8:108,596,100...108,611,441
Ensembl chr 8:108,597,299...108,612,455
G
Mtmr7
myotubularin related protein 7
affects expression
EXP
Orphenadrine affects the expression of MTMR7 mRNA
CTD
PMID:23665939
NCBI chr16:51,641,267...51,732,212
Ensembl chr16:51,641,190...51,732,182
G
Mtss2
MTSS I-BAR domain containing 2
affects expression
EXP
Orphenadrine affects the expression of MTSS2 mRNA
CTD
PMID:23665939
NCBI chr19:38,692,793...38,714,575
Ensembl chr19:38,693,194...38,713,507
G
Mx2
MX dynamin like GTPase 2
affects expression
EXP
Orphenadrine affects the expression of MX2 mRNA
CTD
PMID:23665939
NCBI chr11:36,905,698...36,936,308
Ensembl chr11:36,906,111...36,930,342
G
Mybph
myosin binding protein H
affects expression
EXP
Orphenadrine affects the expression of MYBPH mRNA
CTD
PMID:23665939
NCBI chr13:45,653,156...45,660,893
Ensembl chr13:45,653,234...45,660,893
G
Mypop
Myb-related transcription factor, partner of profilin
affects expression
EXP
Orphenadrine affects the expression of MYPOP mRNA
CTD
PMID:23665939
NCBI chr 1:78,639,699...78,650,555
Ensembl chr 1:78,639,769...78,650,552
G
Myrf
myelin regulatory factor
affects expression
EXP
Orphenadrine affects the expression of MYRF mRNA
CTD
PMID:23665939
NCBI chr 1:206,854,175...206,886,276
Ensembl chr 1:206,854,175...206,886,157
G
Nat8f2
N-acetyltransferase 8 (GCN5-related) family member 2
affects expression
EXP
Orphenadrine affects the expression of NAT8F2 mRNA
CTD
PMID:23665939
NCBI chr 4:118,319,984...118,323,159
Ensembl chr 4:118,319,988...118,324,395
G
Ncaph
non-SMC condensin I complex, subunit H
affects expression
EXP
Orphenadrine affects the expression of NCAPH mRNA
CTD
PMID:23665939
NCBI chr 3:114,371,937...114,399,178
Ensembl chr 3:114,371,941...114,399,180
G
Ncoa7
nuclear receptor coactivator 7
affects expression
EXP
Orphenadrine affects the expression of NCOA7 mRNA
CTD
PMID:23665939
NCBI chr 1:26,856,228...27,016,950
Ensembl chr 1:26,856,530...27,015,871
G
Nefh
neurofilament heavy chain
affects expression
EXP
Orphenadrine affects the expression of NEFH mRNA
CTD
PMID:22954530
NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
G
Neurl3
neuralized E3 ubiquitin protein ligase 3
affects expression
EXP
Orphenadrine affects the expression of NEURL3 mRNA
CTD
PMID:23665939
NCBI chr 9:38,494,486...38,503,352
Ensembl chr 9:38,494,489...38,502,649
G
Nfkbiz
NFKB inhibitor zeta
affects expression
EXP
Orphenadrine affects the expression of NFKBIZ mRNA
CTD
PMID:23665939
NCBI chr11:44,782,676...44,810,722
Ensembl chr11:44,782,676...44,810,723
G
Nhsl3
NHS like 3
affects expression
EXP
Orphenadrine affects the expression of NHSL3 mRNA
CTD
PMID:23665939
NCBI chr 5:141,564,399...141,593,154
Ensembl chr 5:141,564,399...141,593,176
G
Ninj2
ninjurin 2
affects expression
EXP
Orphenadrine affects the expression of NINJ2 mRNA
CTD
PMID:23665939
NCBI chr 4:153,306,439...153,408,618
Ensembl chr 4:153,306,553...153,408,617
G
Nipal2
NIPA-like domain containing 2
affects expression
EXP
Orphenadrine affects the expression of NIPAL2 mRNA
CTD
PMID:23665939
NCBI chr 7:65,774,477...65,884,807
Ensembl chr 7:65,774,477...65,884,807
G
Nlrc4
NLR family, CARD domain containing 4
affects expression
EXP
Orphenadrine affects the expression of NLRC4 mRNA
CTD
PMID:23665939
NCBI chr 6:20,991,785...21,018,254
Ensembl chr 6:20,995,266...21,018,248
G
Noct
nocturnin
affects expression
EXP
Orphenadrine affects the expression of NOCT mRNA
CTD
PMID:23665939
NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400
G
Nos1ap
nitric oxide synthase 1 adaptor protein
affects expression
EXP
Orphenadrine affects the expression of NOS1AP mRNA
CTD
PMID:23665939
NCBI chr13:82,547,799...82,820,999
Ensembl chr13:82,530,577...82,820,949
G
Nos3
nitric oxide synthase 3
affects expression
EXP
Orphenadrine affects the expression of NOS3 mRNA
CTD
PMID:23665939
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
G
Npy
neuropeptide Y
affects expression
EXP
Orphenadrine affects the expression of NPY mRNA
CTD
PMID:23665939
NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
G
Nr1d1
nuclear receptor subfamily 1, group D, member 1
affects expression
EXP
Orphenadrine affects the expression of NR1D1 mRNA
CTD
PMID:23665939
NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705
G
Nrep
neuronal regeneration related protein
affects expression
EXP
Orphenadrine affects the expression of NREP mRNA
CTD
PMID:23665939
NCBI chr18:25,017,069...25,046,593
Ensembl chr18:25,017,083...25,046,591
G
Nrg1
neuregulin 1
affects expression
EXP
Orphenadrine affects the expression of NRG1 mRNA
CTD
PMID:23665939
NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884
G
Nrxn1
neurexin 1
affects expression
EXP
Orphenadrine affects the expression of NRXN1 mRNA
CTD
PMID:23665939
NCBI chr 6:3,177,788...4,323,848
Ensembl chr 6:3,177,897...4,322,710
G
Nupr1
nuclear protein 1, transcriptional regulator
affects expression
EXP
Orphenadrine affects the expression of NUPR1 mRNA
CTD
PMID:23665939
NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281
G
Oat
ornithine aminotransferase
affects expression
EXP
Orphenadrine affects the expression of OAT mRNA
CTD
PMID:23665939
NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682
G
Ogn
osteoglycin
affects expression
EXP
Orphenadrine affects the expression of OGN mRNA
CTD
PMID:23665939
NCBI chr17:15,032,069...15,052,626
Ensembl chr17:15,032,069...15,052,739
G
Olr1198
olfactory receptor 1198
affects expression
EXP
Orphenadrine affects the expression of OLR1198 mRNA
CTD
PMID:23665939
NCBI chr 8:37,575,356...37,576,285
Ensembl chr 8:37,574,531...37,576,995
G
Olr1428
olfactory receptor 1428
affects expression
EXP
Orphenadrine affects the expression of OLR1428 mRNA
CTD
PMID:23665939
NCBI chr10:42,947,353...42,948,300
Ensembl chr10:42,944,142...42,948,881
G
Olr1451
olfactory receptor 1451
affects expression
EXP
Orphenadrine affects the expression of OLR1451 mRNA
CTD
PMID:23665939
NCBI chr10:43,429,140...43,430,069
Ensembl chr10:43,424,036...43,432,210
G
Omd
osteomodulin
affects expression
EXP
Orphenadrine affects the expression of OMD mRNA
CTD
PMID:23665939
NCBI chr17:15,060,217...15,068,441
Ensembl chr17:15,060,217...15,068,441
G
Or2n1l
olfactory receptor family 2 subfamily N member 1L
affects expression
EXP
Orphenadrine affects the expression of OR2N1L mRNA
CTD
PMID:23665939
NCBI chr20:340,574...341,512
G
Or2y1i
olfactory receptor family 2 subfamily Y member 1I
affects expression
EXP
Orphenadrine affects the expression of OR2Y1I mRNA
CTD
PMID:23665939
NCBI chr10:33,737,199...33,738,128
Ensembl chr10:33,732,012...33,738,729
G
Osgin1
oxidative stress induced growth inhibitor 1
affects expression
EXP
Orphenadrine affects the expression of OSGIN1 mRNA
CTD
PMID:23665939
NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516
G
P3h2
prolyl 3-hydroxylase 2
affects expression
EXP
Orphenadrine affects the expression of P3H2 mRNA
CTD
PMID:23665939
NCBI chr11:74,634,267...74,775,422
Ensembl chr11:74,634,267...74,775,421
G
P3h4
prolyl 3-hydroxylase family member 4
affects expression
EXP
Orphenadrine affects the expression of P3H4 mRNA
CTD
PMID:23665939
NCBI chr10:85,338,158...85,345,108
Ensembl chr10:85,338,161...85,345,093
G
Panx2
pannexin 2
affects expression
EXP
Orphenadrine affects the expression of PANX2 mRNA
CTD
PMID:23665939
NCBI chr 7:120,139,259...120,153,056
Ensembl chr 7:120,139,294...120,152,361
G
Pcdh12
protocadherin 12
affects expression
EXP
Orphenadrine affects the expression of PCDH12 mRNA
CTD
PMID:23665939
NCBI chr18:30,103,728...30,119,307
Ensembl chr18:30,103,728...30,119,307
G
Pcp4l1
Purkinje cell protein 4-like 1
affects expression
EXP
Orphenadrine affects the expression of PCP4L1 mRNA
CTD
PMID:23665939
NCBI chr13:83,588,992...83,612,631
Ensembl chr13:83,588,992...83,609,966
G
Pcsk9
proprotein convertase subtilisin/kexin type 9
affects expression
EXP
Orphenadrine affects the expression of PCSK9 mRNA
CTD
PMID:23665939
NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688
G
Pde5a
phosphodiesterase 5A
affects expression
EXP
Orphenadrine affects the expression of PDE5A mRNA
CTD
PMID:23665939
NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
G
Pdk4
pyruvate dehydrogenase kinase 4
affects expression
EXP
Orphenadrine affects the expression of PDK4 mRNA
CTD
PMID:23665939
NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
G
Pdpn
podoplanin
affects expression
EXP
Orphenadrine affects the expression of PDPN mRNA
CTD
PMID:23665939
NCBI chr 5:155,601,691...155,635,656
Ensembl chr 5:155,601,691...155,635,656
G
Per2
period circadian regulator 2
affects expression
EXP
Orphenadrine affects the expression of PER2 mRNA
CTD
PMID:23665939
NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459
G
Pfkm
phosphofructokinase, muscle
affects expression
EXP
Orphenadrine affects the expression of PFKM mRNA
CTD
PMID:23665939
NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192
G
Phlda2
pleckstrin homology-like domain, family A, member 2
affects expression
EXP
Orphenadrine affects the expression of PHLDA2 mRNA
CTD
PMID:23665939
NCBI chr 1:198,696,897...198,699,292
Ensembl chr 1:198,696,897...198,697,836
G
Phlda3
pleckstrin homology-like domain, family A, member 3
affects expression
EXP
Orphenadrine affects the expression of PHLDA3 mRNA
CTD
PMID:23665939
NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335
G
Phldb3
pleckstrin homology-like domain, family B, member 3
affects expression
EXP
Orphenadrine affects the expression of PHLDB3 mRNA
CTD
PMID:23665939
NCBI chr 1:80,201,083...80,219,541
Ensembl chr 1:80,201,578...80,219,534
G
Phospho1
phosphoethanolamine/phosphocholine phosphatase 1
affects expression
EXP
Orphenadrine affects the expression of PHOSPHO1 mRNA
CTD
PMID:23665939
NCBI chr10:80,762,062...80,769,596
Ensembl chr10:80,760,792...80,770,342
G
Pip5k1c
phosphatidylinositol-4-phosphate 5-kinase type 1 gamma
affects expression
EXP
Orphenadrine affects the expression of PIP5K1C mRNA
CTD
PMID:23665939
NCBI chr 7:8,397,406...8,426,030
Ensembl chr 7:8,397,406...8,425,988
G
Plekhf2
pleckstrin homology and FYVE domain containing 2
affects expression
EXP
Orphenadrine affects the expression of PLEKHF2 mRNA
CTD
PMID:23665939
NCBI chr 5:24,091,077...24,106,758
Ensembl chr 5:24,090,688...24,106,601
G
Plekhh1
pleckstrin homology, MyTH4 and FERM domain containing H1
affects expression
EXP
Orphenadrine affects the expression of PLEKHH1 mRNA
CTD
PMID:23665939
NCBI chr 6:97,839,288...97,888,712
Ensembl chr 6:97,839,288...97,888,709
G
Plin3
perilipin 3
affects expression
EXP
Orphenadrine affects the expression of PLIN3 mRNA
CTD
PMID:23665939
NCBI chr 9:1,111,178...1,123,057
Ensembl chr 9:1,102,366...1,123,147
G
Pmepa1
prostate transmembrane protein, androgen induced 1
affects expression
EXP
Orphenadrine affects the expression of PMEPA1 mRNA
CTD
PMID:23665939
NCBI chr 3:162,011,884...162,060,343
Ensembl chr 3:162,012,751...162,060,454
G
Pmp22
peripheral myelin protein 22
affects expression
EXP
Orphenadrine affects the expression of PMP22 mRNA
CTD
PMID:23665939
NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714
G
Polg2
DNA polymerase gamma 2, accessory subunit
affects expression
EXP
Orphenadrine affects the expression of POLG2 mRNA
CTD
PMID:23665939
NCBI chr10:91,712,586...91,723,008
Ensembl chr10:91,712,586...91,723,008
G
Ppm1j
protein phosphatase, Mg2+/Mn2+ dependent, 1J
affects expression
EXP
Orphenadrine affects the expression of PPM1J mRNA
CTD
PMID:23665939
NCBI chr 2:192,278,597...192,283,883
Ensembl chr 2:192,278,517...192,283,882
G
Ppm1k
protein phosphatase, Mg2+/Mn2+ dependent, 1K
affects expression
EXP
Orphenadrine affects the expression of PPM1K mRNA
CTD
PMID:23665939
NCBI chr 4:87,612,198...87,638,993
Ensembl chr 4:87,612,204...87,636,152
G
Ppp1r1a
protein phosphatase 1, regulatory (inhibitor) subunit 1A
affects expression
EXP
Orphenadrine affects the expression of PPP1R1A mRNA
CTD
PMID:23665939
NCBI chr 7:134,654,578...134,662,236
Ensembl chr 7:134,654,579...134,662,230
G
Prelid2
PRELI domain containing 2
affects expression
EXP
Orphenadrine affects the expression of PRELID2 mRNA
CTD
PMID:23665939
NCBI chr18:33,869,934...33,961,320
Ensembl chr18:33,873,599...33,961,225
G
Prkch
protein kinase C, eta
affects expression
EXP
Orphenadrine affects the expression of PRKCH mRNA
CTD
PMID:23665939
NCBI chr 6:92,292,000...92,490,663
Ensembl chr 6:92,292,000...92,490,654
G
Prlr
prolactin receptor
affects expression
EXP
Orphenadrine affects the expression of PRLR mRNA
CTD
PMID:23665939
NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718
G
Prp2
proline rich protein 2
affects expression
EXP
Orphenadrine affects the expression of PRP2 mRNA
CTD
PMID:23665939
NCBI chr 4:165,600,085...165,603,662
G
Prrg4
proline rich and Gla domain 4
affects expression
EXP
Orphenadrine affects the expression of PRRG4 mRNA
CTD
PMID:23665939
NCBI chr 3:91,214,646...91,243,347
Ensembl chr 3:91,214,653...91,243,273
G
Prss53
serine protease 53
affects expression
EXP
Orphenadrine affects the expression of PRSS53 mRNA
CTD
PMID:23665939
NCBI chr 1:182,494,944...182,501,607
Ensembl chr 1:182,494,955...182,500,115
G
Ptprn
protein tyrosine phosphatase, receptor type, N
affects expression
EXP
Orphenadrine affects the expression of PTPRN mRNA
CTD
PMID:23665939
NCBI chr 9:76,741,010...76,756,704
Ensembl chr 9:76,741,016...76,756,190
G
Pvr
PVR cell adhesion molecule
affects expression
EXP
Orphenadrine affects the expression of PVR mRNA
CTD
PMID:23665939
NCBI chr 1:79,561,294...79,576,700
Ensembl chr 1:79,546,879...79,576,715
G
Pwwp2b
PWWP domain containing 2B
affects expression
EXP
Orphenadrine affects the expression of PWWP2B mRNA
CTD
PMID:23665939
NCBI chr 1:194,040,395...194,059,979
Ensembl chr 1:194,041,341...194,059,958
G
Rab11fip5
RAB11 family interacting protein 5
affects expression
EXP
Orphenadrine affects the expression of RAB11FIP5 mRNA
CTD
PMID:23665939
NCBI chr 4:117,871,301...117,908,819
Ensembl chr 4:117,871,308...117,908,741
G
Rab23
RAB23, member RAS oncogene family
affects expression
EXP
Orphenadrine affects the expression of RAB23 mRNA
CTD
PMID:23665939
NCBI chr 9:35,943,522...35,967,367
Ensembl chr 9:35,944,085...35,966,927
G
Rab3d
RAB3D, member RAS oncogene family
affects expression
EXP
Orphenadrine affects the expression of RAB3D mRNA
CTD
PMID:23665939
NCBI chr 8:20,438,622...20,449,269
Ensembl chr 8:20,439,294...20,449,185
G
Rarg
retinoic acid receptor, gamma
affects expression
EXP
Orphenadrine affects the expression of RARG mRNA
CTD
PMID:23665939
NCBI chr 7:133,367,833...133,390,301
Ensembl chr 7:133,367,833...133,390,177
G
Rassf1
Ras association domain family member 1
affects expression
EXP
Orphenadrine affects the expression of RASSF1 mRNA
CTD
PMID:23665939
NCBI chr 8:108,225,023...108,236,164
Ensembl chr 8:108,225,023...108,236,164
G
Rell1
RELT-like 1
affects expression
EXP
Orphenadrine affects the expression of RELL1 mRNA
CTD
PMID:23665939
NCBI chr14:44,318,640...44,378,541
Ensembl chr14:44,303,009...44,378,500
G
Renbp
renin binding protein
affects expression
EXP
Orphenadrine affects the expression of RENBP mRNA
CTD
PMID:23665939
NCBI chr X:151,661,463...151,670,538
Ensembl chr X:151,661,458...151,670,516
G
Repin1
replication initiator 1
affects expression
EXP
Orphenadrine affects the expression of REPIN1 mRNA
CTD
PMID:23665939
NCBI chr 4:77,548,724...77,554,242
Ensembl chr 4:77,548,849...77,554,257
G
Resp18
regulated endocrine-specific protein 18
affects expression
EXP
Orphenadrine affects the expression of RESP18 mRNA
CTD
PMID:23665939
NCBI chr 9:76,765,179...76,771,824
Ensembl chr 9:76,764,590...76,778,722
G
Rgs16
regulator of G-protein signaling 16
affects expression
EXP
Orphenadrine affects the expression of RGS16 mRNA
CTD
PMID:23665939
NCBI chr13:65,887,668...65,892,862
Ensembl chr13:65,887,530...65,892,857
G
Rhbdf2
rhomboid 5 homolog 2
affects expression
EXP
Orphenadrine affects the expression of RHBDF2 mRNA
CTD
PMID:23665939
NCBI chr10:101,833,157...101,860,283
Ensembl chr10:101,833,157...101,860,283
G
Rhoc
ras homolog family member C
affects expression
EXP
Orphenadrine affects the expression of RHOC mRNA
CTD
PMID:23665939
NCBI chr 2:192,287,065...192,293,292
Ensembl chr 2:192,287,130...192,295,306
G
Rhof
ras homolog family member F, filopodia associated
affects expression
EXP
Orphenadrine affects the expression of RHOF mRNA
CTD
PMID:23665939
NCBI chr12:33,422,375...33,446,689
Ensembl chr12:33,431,280...33,446,703
G
Rmdn2
regulator of microtubule dynamics 2
affects expression
EXP
Orphenadrine affects the expression of RMDN2 mRNA
CTD
PMID:23665939
NCBI chr 6:15,372,569...15,443,000
Ensembl chr 6:15,375,496...15,441,480
G
Rnd1
Rho family GTPase 1
affects expression
EXP
Orphenadrine affects the expression of RND1 mRNA
CTD
PMID:23665939
NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399
G
Sbspon
somatomedin B and thrombospondin, type 1 domain containing
affects expression
EXP
Orphenadrine affects the expression of SBSPON mRNA
CTD
PMID:23665939
NCBI chr 5:3,402,763...3,433,338
Ensembl chr 5:3,402,648...3,435,420
G
Scd
stearoyl-CoA desaturase
affects expression
EXP
Orphenadrine affects the expression of SCD1 mRNA
CTD
PMID:23665939
NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
G
Scnn1a
sodium channel epithelial 1 subunit alpha
affects expression
EXP
Orphenadrine affects the expression of SCNN1A mRNA
CTD
PMID:23665939
NCBI chr 4:158,122,962...158,146,184
Ensembl chr 4:158,122,962...158,146,181
G
Sdc3
syndecan 3
affects expression
EXP
Orphenadrine affects the expression of SDC3 mRNA
CTD
PMID:23665939
NCBI chr 5:142,965,659...142,998,390
Ensembl chr 5:142,965,591...142,996,480
G
Sebox
SEBOX homeobox
affects expression
EXP
Orphenadrine affects the expression of SEBOX mRNA
CTD
PMID:23665939
NCBI chr10:63,399,215...63,400,086
Ensembl chr10:63,399,165...63,400,606
G
Serinc2
serine incorporator 2
affects expression
EXP
Orphenadrine affects the expression of SERINC2 mRNA
CTD
PMID:23665939
NCBI chr 5:142,592,308...142,614,628
Ensembl chr 5:142,592,309...142,618,364
G
Serpina7
serpin family A member 7
affects expression
EXP
Orphenadrine affects the expression of SERPINA7 mRNA
CTD
PMID:23665939
NCBI chr X:102,663,242...102,722,319
Ensembl chr X:102,663,405...102,669,040
G
Sertad1
SERTA domain containing 1
affects expression
EXP
Orphenadrine affects the expression of SERTAD1 mRNA
CTD
PMID:23665939
NCBI chr 1:82,775,692...82,778,961
Ensembl chr 1:82,775,252...82,779,091
G
Setd7
SET domain containing 7, histone lysine methyltransferase
affects expression
EXP
Orphenadrine affects the expression of SETD7 mRNA
CTD
PMID:23665939
NCBI chr 2:135,562,683...135,605,468
Ensembl chr 2:135,562,683...135,605,468
G
Sgk1
serum/glucocorticoid regulated kinase 1
affects expression
EXP
Orphenadrine affects the expression of SGK1 mRNA
CTD
PMID:23665939
NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
G
Sh3pxd2b
SH3 and PX domains 2B
affects expression
EXP
Orphenadrine affects the expression of SH3PXD2B mRNA
CTD
PMID:23665939
NCBI chr10:16,918,611...17,027,499
Ensembl chr10:16,918,679...17,005,170
G
Shank3
SH3 and multiple ankyrin repeat domains 3
affects expression
EXP
Orphenadrine affects the expression of SHANK3 mRNA
CTD
PMID:23665939
NCBI chr 7:120,568,707...120,630,796
Ensembl chr 7:120,570,402...120,630,374
G
Shisa4
shisa family member 4
affects expression
EXP
Orphenadrine affects the expression of SHISA4 mRNA
CTD
PMID:23665939
NCBI chr13:46,799,735...46,803,816
Ensembl chr13:46,799,772...46,803,998
G
Shroom3
shroom family member 3
affects expression
EXP
Orphenadrine affects the expression of SHROOM3 mRNA
CTD
PMID:23665939
NCBI chr14:15,099,415...15,396,832
Ensembl chr14:15,099,423...15,396,915
G
Sidt1
SID1 transmembrane family, member 1
affects expression
EXP
Orphenadrine affects the expression of SIDT1 mRNA
CTD
PMID:23665939
NCBI chr11:56,362,788...56,459,939
Ensembl chr11:56,363,512...56,459,050
G
Sinhcaf
SIN3-HDAC complex associated factor
affects expression
EXP
Orphenadrine affects the expression of SINHCAF mRNA
CTD
PMID:23665939
NCBI chr 4:181,888,301...181,913,294
Ensembl chr 4:181,888,312...181,910,276
G
Sipa1
signal-induced proliferation-associated 1
affects expression
EXP
Orphenadrine affects the expression of SIPA1 mRNA
CTD
PMID:23665939
NCBI chr 1:202,938,532...202,950,672
Ensembl chr 1:202,938,580...202,950,591
G
Skil
SKI-like proto-oncogene
affects expression
EXP
Orphenadrine affects the expression of SKIL mRNA
CTD
PMID:23665939
NCBI chr 2:112,247,047...112,275,176
Ensembl chr 2:112,247,051...112,275,080
G
Slc12a4
solute carrier family 12 member 4
affects expression
EXP
Orphenadrine affects the expression of SLC12A4 mRNA
CTD
PMID:23665939
NCBI chr19:33,838,418...33,860,369
Ensembl chr19:33,838,419...33,860,331
G
Slc16a10
solute carrier family 16 member 10
affects expression
EXP
Orphenadrine affects the expression of SLC16A10 mRNA
CTD
PMID:23665939
NCBI chr20:43,454,819...43,567,839
Ensembl chr20:43,459,709...43,567,839
G
Slc16a11
solute carrier family 16, member 11
affects expression
EXP
Orphenadrine affects the expression of SLC16A11 mRNA
CTD
PMID:23665939
NCBI chr10:54,929,129...54,933,021
Ensembl chr10:54,927,725...54,942,915
G
Slc16a14
solute carrier family 16, member 14
affects expression
EXP
Orphenadrine affects the expression of SLC16A14 mRNA
CTD
PMID:23665939
NCBI chr 9:86,110,066...86,137,546
Ensembl chr 9:86,112,894...86,137,318
G
Slc16a5
solute carrier family 16 member 5
affects expression
EXP
Orphenadrine affects the expression of SLC16A5 mRNA
CTD
PMID:23665939
NCBI chr10:100,707,434...100,721,338
Ensembl chr10:100,707,434...100,721,338
G
Slc16a6
solute carrier family 16, member 6
affects expression
EXP
Orphenadrine affects the expression of SLC16A6 mRNA
CTD
PMID:23665939
NCBI chr10:94,424,377...94,447,482
Ensembl chr10:94,426,244...94,448,779
G
Slc1a4
solute carrier family 1 member 4
affects expression
EXP
Orphenadrine affects the expression of SLC1A4 mRNA
CTD
PMID:23665939
NCBI chr14:94,530,801...94,560,190
Ensembl chr14:94,529,084...94,560,418
G
Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Orphenadrine inhibits the reaction [SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Orphenadrine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
G
Slc30a2
solute carrier family 30 member 2
affects expression
EXP
Orphenadrine affects the expression of SLC30A2 mRNA
CTD
PMID:23665939
NCBI chr 5:146,559,733...146,571,957
Ensembl chr 5:146,559,733...146,571,956
G
Slc35f2
solute carrier family 35, member F2
affects expression
EXP
Orphenadrine affects the expression of SLC35F2 mRNA
CTD
PMID:23665939
NCBI chr 8:54,159,970...54,203,614
Ensembl chr 8:54,159,970...54,203,612
G
Slc41a1
solute carrier family 41 member 1
affects expression
EXP
Orphenadrine affects the expression of SLC41A1 mRNA
CTD
PMID:23665939
NCBI chr13:43,270,792...43,291,162
Ensembl chr13:43,270,792...43,291,162
G
Slc6a8
solute carrier family 6 member 8
affects expression
EXP
Orphenadrine affects the expression of SLC6A8 mRNA
CTD
PMID:23665939
NCBI chr X:151,384,675...151,393,979
Ensembl chr X:151,384,675...151,393,979
G
Slc7a4
solute carrier family 7, member 4
affects expression
EXP
Orphenadrine affects the expression of SLC7A4 mRNA
CTD
PMID:23665939
NCBI chr11:83,435,093...83,439,078
Ensembl chr11:83,435,211...83,438,881
G
Slc9a7
solute carrier family 9 member A7
affects expression
EXP
Orphenadrine affects the expression of SLC9A7 mRNA
CTD
PMID:23665939
NCBI chr X:2,214,064...2,395,052
Ensembl chr X:2,214,441...2,388,012
G
Smad6
SMAD family member 6
affects expression
EXP
Orphenadrine affects the expression of SMAD6 mRNA
CTD
PMID:23665939
NCBI chr 8:64,450,114...64,519,673
Ensembl chr 8:64,450,114...64,519,763
G
Smtnl2
smoothelin-like 2
affects expression
EXP
Orphenadrine affects the expression of SMTNL2 mRNA
CTD
PMID:23665939
NCBI chr10:57,008,322...57,029,505
Ensembl chr10:57,008,327...57,029,505
G
Snx10
sorting nexin 10
affects expression
EXP
Orphenadrine affects the expression of SNX10 mRNA
CTD
PMID:23665939
NCBI chr 4:80,612,648...80,677,005
Ensembl chr 4:80,612,669...80,676,996
G
Sort1
sortilin 1
affects expression
EXP
Orphenadrine affects the expression of SORT1 mRNA
CTD
PMID:23665939
NCBI chr 2:195,924,033...196,002,354
Ensembl chr 2:195,924,099...196,002,354
G
Sox18
SRY-box transcription factor 18
affects expression
EXP
Orphenadrine affects the expression of SOX18 mRNA
CTD
PMID:23665939
NCBI chr 3:168,785,488...168,787,290
Ensembl chr 3:168,785,490...168,787,290
G
Sox4
SRY-box transcription factor 4
affects expression
EXP
Orphenadrine affects the expression of SOX4 mRNA
CTD
PMID:23665939
NCBI chr17:35,667,809...35,672,515
Ensembl chr17:35,667,537...35,673,665
G
Spc25
SPC25 component of NDC80 kinetochore complex
affects expression
EXP
Orphenadrine affects the expression of SPC25 mRNA
CTD
PMID:23665939
NCBI chr 3:53,930,013...53,988,940
Ensembl chr 3:53,975,704...53,988,959
G
Spetex2c
Spetex-2C protein
affects expression
EXP
Orphenadrine affects the expression of SPETEX2C mRNA
CTD
PMID:23665939
NCBI chr15:4,779,251...4,781,549
Ensembl chr15:4,779,229...4,781,731
G
Spetex2f
Spetex-2F protein
affects expression
EXP
Orphenadrine affects the expression of SPETEX2F mRNA
CTD
PMID:23665939
NCBI chr15:17,716,315...17,720,203
Ensembl chr15:17,716,358...17,733,744
G
Spetex2g
Spetex-2G protein
affects expression
EXP
Orphenadrine affects the expression of SPETEX2G mRNA
CTD
PMID:23665939
NCBI chr15:4,615,554...4,619,166
Ensembl chr15:4,615,466...4,662,812
G
Spink9
serine peptidase inhibitor, Kazal type 9
affects expression
EXP
Orphenadrine affects the expression of SPINK9 mRNA
CTD
PMID:23665939
NCBI chr18:36,427,043...36,430,271
Ensembl chr18:36,426,989...36,430,271
G
Spock2
SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2
affects expression
EXP
Orphenadrine affects the expression of SPOCK2 mRNA
CTD
PMID:23665939
NCBI chr20:28,037,334...28,064,272
Ensembl chr20:28,033,475...28,064,272
G
Srcin1
SRC kinase signaling inhibitor 1
affects expression
EXP
Orphenadrine affects the expression of SRCIN1 mRNA
CTD
PMID:23665939
NCBI chr10:82,502,911...82,569,882
Ensembl chr10:82,504,393...82,571,040
G
Srd5a1
steroid 5 alpha-reductase 1
affects expression
EXP
Orphenadrine affects the expression of SRD5A1 mRNA
CTD
PMID:23665939
NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461
G
Stac3
SH3 and cysteine rich domain 3
affects expression
EXP
Orphenadrine affects the expression of STAC3 mRNA
CTD
PMID:23665939
NCBI chr 7:63,343,078...63,350,590
Ensembl chr 7:63,343,186...63,350,589
G
Stard9
StAR-related lipid transfer domain containing 9
affects expression
EXP
Orphenadrine affects the expression of STARD9 mRNA
CTD
PMID:23665939
NCBI chr 3:107,581,097...107,672,746
Ensembl chr 3:107,581,164...107,673,898
G
Stxbp1
syntaxin binding protein 1
affects expression
EXP
Orphenadrine affects the expression of STXBP1 mRNA
CTD
PMID:23665939
NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369
G
Sult1e1
sulfotransferase family 1E member 1
affects expression
EXP
Orphenadrine affects the expression of SULT1E1 mRNA
CTD
PMID:23665939
NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275
G
Syde1
synapse defective Rho GTPase homolog 1
affects expression
EXP
Orphenadrine affects the expression of SYDE1 mRNA
CTD
PMID:23665939
NCBI chr 7:11,032,931...11,038,917
Ensembl chr 7:11,032,898...11,039,869
G
Syngap1
synaptic Ras GTPase activating protein 1
affects expression
EXP
Orphenadrine affects the expression of SYNGAP1 mRNA
CTD
PMID:23665939
NCBI chr20:5,026,366...5,056,659
Ensembl chr20:5,026,364...5,056,672
G
Synj2
synaptojanin 2
affects expression
EXP
Orphenadrine affects the expression of SYNJ2 mRNA
CTD
PMID:23665939
NCBI chr 1:46,518,594...46,621,919
Ensembl chr 1:46,518,709...46,633,687
G
Synm
synemin
affects expression
EXP
Orphenadrine affects the expression of SYNM mRNA
CTD
PMID:23665939
NCBI chr 1:121,333,712...121,363,652
Ensembl chr 1:121,333,720...121,363,652
G
Tbcel
tubulin folding cofactor E-like
affects expression
EXP
Orphenadrine affects the expression of TBCEL mRNA
CTD
PMID:23665939
NCBI chr 8:42,795,648...42,854,552
Ensembl chr 8:42,796,730...42,854,552
G
Tead2
TEA domain transcription factor 2
affects expression
EXP
Orphenadrine affects the expression of TEAD2 mRNA
CTD
PMID:23665939
NCBI chr 1:95,702,366...95,719,186
Ensembl chr 1:95,703,005...95,719,186
G
Tenm2
teneurin transmembrane protein 2
affects expression
EXP
Orphenadrine affects the expression of TENM2 mRNA
CTD
PMID:23665939
NCBI chr10:20,480,662...21,706,415
Ensembl chr10:20,481,854...21,705,597
G
Tex13b
testis expressed 13B
affects expression
EXP
Orphenadrine affects the expression of TEX13B mRNA
CTD
PMID:23665939
NCBI chr X:104,490,937...104,511,224
Ensembl chr X:104,490,091...104,494,201
G
Tex36
testis expressed 36
affects expression
EXP
Orphenadrine affects the expression of TEX36 mRNA
CTD
PMID:23665939
NCBI chr 1:188,390,062...188,404,448
Ensembl chr 1:188,390,064...188,404,377
G
Them6
thioesterase superfamily member 6
affects expression
EXP
Orphenadrine affects the expression of THEM6 mRNA
CTD
PMID:23665939
NCBI chr 7:106,606,570...106,609,747
Ensembl chr 7:106,606,570...106,609,746
G
Tifa
TRAF-interacting protein with forkhead-associated domain
affects expression
EXP
Orphenadrine affects the expression of TIFA mRNA
CTD
PMID:23665939
NCBI chr 2:216,257,926...216,267,635
Ensembl chr 2:216,234,774...216,267,841
G
Tlcd4
TLC domain containing 4
affects expression
EXP
Orphenadrine affects the expression of TLCD4 mRNA
CTD
PMID:23665939
NCBI chr 2:209,284,873...209,360,156
Ensembl chr 2:209,289,732...209,341,353
G
Tlnrd1
talin rod domain containing 1
affects expression
EXP
Orphenadrine affects the expression of TLNRD1 mRNA
CTD
PMID:23665939
NCBI chr 1:137,864,340...137,866,359
Ensembl chr 1:137,864,343...137,866,359
G
Tmbim1
transmembrane BAX inhibitor motif containing 1
affects expression
EXP
Orphenadrine affects the expression of TMBIM1 mRNA
CTD
PMID:23665939
NCBI chr 9:75,871,835...75,889,366
Ensembl chr 9:75,871,835...75,889,069
G
Tmem184b
transmembrane protein 184B
affects expression
EXP
Orphenadrine affects the expression of TMEM184B mRNA
CTD
PMID:23665939
NCBI chr 7:110,925,092...110,967,975
Ensembl chr 7:110,925,092...110,967,943
G
Tmem184c
transmembrane protein 184C
affects expression
EXP
Orphenadrine affects the expression of TMEM184C mRNA
CTD
PMID:23665939
NCBI chr19:30,345,183...30,361,275
Ensembl chr19:30,345,290...30,361,269
G
Tmem200b
transmembrane protein 200B
affects expression
EXP
Orphenadrine affects the expression of TMEM200B mRNA
CTD
PMID:23665939
NCBI chr 5:144,107,795...144,110,551
Ensembl chr 5:144,103,550...144,112,506
G
Tnfaip2
TNF alpha induced protein 2
affects expression
EXP
Orphenadrine affects the expression of TNFAIP2 mRNA
CTD
PMID:23665939
NCBI chr 6:130,476,832...130,489,914
Ensembl chr 6:130,476,889...130,489,914
G
Tnfrsf11b
TNF receptor superfamily member 11B
affects expression
EXP
Orphenadrine affects the expression of TNFRSF11B mRNA
CTD
PMID:23665939
NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
G
Tnfrsf12a
TNF receptor superfamily member 12A
affects expression
EXP
Orphenadrine affects the expression of TNFRSF12A mRNA
CTD
PMID:23665939
NCBI chr10:12,707,077...12,709,071
Ensembl chr10:12,689,890...12,709,045
G
Tnk1
tyrosine kinase, non-receptor, 1
affects expression
EXP
Orphenadrine affects the expression of TNK1 mRNA
CTD
PMID:23665939
NCBI chr10:54,571,396...54,580,547
Ensembl chr10:54,571,117...54,579,940
G
Tns1
tensin 1
affects expression
EXP
Orphenadrine affects the expression of TNS1 mRNA
CTD
PMID:23665939
NCBI chr 9:75,491,886...75,702,853
Ensembl chr 9:75,495,814...75,703,225
G
Togaram2
TOG array regulator of axonemal microtubules 2
affects expression
EXP
Orphenadrine affects the expression of TOGARAM2 mRNA
CTD
PMID:23665939
NCBI chr 6:23,770,979...23,828,884
Ensembl chr 6:23,771,052...23,828,499
G
Tox3
TOX high mobility group box family member 3
affects expression
EXP
Orphenadrine affects the expression of TOX3 mRNA
CTD
PMID:23665939
NCBI chr19:16,648,338...16,757,151
Ensembl chr19:16,648,342...16,757,148
G
Tpm1
tropomyosin 1
affects expression
EXP
Orphenadrine affects the expression of TPM1 mRNA
CTD
PMID:23665939
NCBI chr 8:67,635,479...67,662,330
Ensembl chr 8:67,635,479...67,662,802
G
Traf4
Tnf receptor associated factor 4
affects expression
EXP
Orphenadrine affects the expression of TRAF4 mRNA
CTD
PMID:23665939
NCBI chr10:63,054,169...63,060,284
Ensembl chr10:63,054,181...63,060,284
G
Trim36
tripartite motif-containing 36
affects expression
EXP
Orphenadrine affects the expression of TRIM36 mRNA
CTD
PMID:23665939
NCBI chr18:38,859,604...38,912,859
Ensembl chr18:38,861,018...38,912,859
G
Trim54
tripartite motif-containing 54
affects expression
EXP
Orphenadrine affects the expression of TRIM54 mRNA
CTD
PMID:23665939
NCBI chr 6:25,239,340...25,258,511
Ensembl chr 6:25,239,340...25,258,511
G
Trpm2
transient receptor potential cation channel, subfamily M, member 2
affects expression
EXP
Orphenadrine affects the expression of TRPM2 mRNA
CTD
PMID:23665939
NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181
G
Trpv2
transient receptor potential cation channel, subfamily V, member 2
affects expression
EXP
Orphenadrine affects the expression of TRPV2 mRNA
CTD
PMID:23665939
NCBI chr10:47,265,524...47,294,263
Ensembl chr10:47,272,931...47,294,260
G
Tsc22d3
TSC22 domain family, member 3
affects expression
EXP
Orphenadrine affects the expression of TSC22D3 mRNA
CTD
PMID:23665939
NCBI chr X:104,217,898...104,277,886
Ensembl chr X:104,217,925...104,276,861
G
Ttpal
alpha tocopherol transfer protein like
affects expression
EXP
Orphenadrine affects the expression of TTPAL mRNA
CTD
PMID:23665939
NCBI chr 3:152,278,246...152,296,550
Ensembl chr 3:152,278,303...152,296,513
G
Uba7
ubiquitin-like modifier activating enzyme 7
affects expression
EXP
Orphenadrine affects the expression of UBA7 mRNA
CTD
PMID:23665939
NCBI chr 8:108,665,289...108,674,097
Ensembl chr 8:108,665,292...108,674,099
G
Ugt2a3
UDP glucuronosyltransferase family 2 member A3
affects expression
EXP
Orphenadrine affects the expression of UGT2A3 mRNA
CTD
PMID:23665939
NCBI chr14:20,572,793...20,590,795
Ensembl chr14:20,572,808...20,590,729
G
Ugt2b1
UDP glucuronosyltransferase 2 family, polypeptide B1
affects expression
EXP
Orphenadrine affects the expression of UGT2B1 mRNA
CTD
PMID:23665939
NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
G
Unc5b
unc-5 netrin receptor B
affects expression
EXP
Orphenadrine affects the expression of UNC5B mRNA
CTD
PMID:23665939
NCBI chr20:28,697,726...28,764,474
Ensembl chr20:28,697,726...28,764,537
G
Unkl
unk like zinc finger
affects expression
EXP
Orphenadrine affects the expression of UNKL mRNA
CTD
PMID:23665939
NCBI chr10:14,206,125...14,252,226
Ensembl chr10:14,206,189...14,252,225
G
Upp2
uridine phosphorylase 2
affects expression
EXP
Orphenadrine affects the expression of UPP2 mRNA
CTD
PMID:23665939
NCBI chr 3:43,273,048...43,317,417
Ensembl chr 3:43,273,048...43,317,417
G
Usp18
ubiquitin specific peptidase 18
affects expression
EXP
Orphenadrine affects the expression of USP18 mRNA
CTD
PMID:23665939
NCBI chr 4:154,471,634...154,499,154
Ensembl chr 4:154,471,592...154,499,144
G
UST4r
integral membrane transport protein UST4r
affects expression
EXP
Orphenadrine affects the expression of UST4R mRNA
CTD
PMID:23665939
NCBI chr 1:205,072,204...205,142,718
Ensembl chr 1:205,072,296...205,142,691
G
Vav2
vav guanine nucleotide exchange factor 2
affects expression
EXP
Orphenadrine affects the expression of VAV2 mRNA
CTD
PMID:23665939
NCBI chr 3:10,584,688...10,754,128
Ensembl chr 3:10,584,688...10,754,052
G
Vipr1
vasoactive intestinal peptide receptor 1
affects expression
EXP
Orphenadrine affects the expression of VIPR1 mRNA
CTD
PMID:23665939
NCBI chr 8:121,303,739...121,339,587
Ensembl chr 8:121,310,248...121,339,585
G
Vnn1
vanin 1
affects expression
EXP
Orphenadrine affects the expression of VNN1 mRNA
CTD
PMID:23665939
NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395
G
Vom2r3
vomeronasal 2 receptor, 3
affects expression
EXP
Orphenadrine affects the expression of VOM2R3 mRNA
CTD
PMID:23665939
NCBI chr 1:76,909...85,784
Ensembl chr 1:76,834...358,271
G
Wfdc1
WAP four-disulfide core domain 1
affects expression
EXP
Orphenadrine affects the expression of WFDC1 mRNA
CTD
PMID:23665939
NCBI chr19:47,720,191...47,739,121
Ensembl chr19:47,720,423...47,739,108
G
Wipf3
WAS/WASL interacting protein family, member 3
affects expression
EXP
Orphenadrine affects the expression of WIPF3 mRNA
CTD
PMID:23665939
NCBI chr 4:83,550,075...83,629,929
Ensembl chr 4:83,550,468...83,629,386
G
Xpnpep2
X-prolyl aminopeptidase 2
affects expression
EXP
Orphenadrine affects the expression of XPNPEP2 mRNA
CTD
PMID:23665939
NCBI chr X:127,287,765...127,317,036
Ensembl chr X:127,287,979...127,317,223
G
Zbtb10
zinc finger and BTB domain containing 10
affects expression
EXP
Orphenadrine affects the expression of ZBTB10 mRNA
CTD
PMID:23665939
NCBI chr 2:92,475,254...92,509,892
Ensembl chr 2:92,479,014...92,512,515
G
Zbtb42
zinc finger and BTB domain containing 42
affects expression
EXP
Orphenadrine affects the expression of ZBTB42 mRNA
CTD
PMID:23665939
NCBI chr 6:131,734,257...131,742,459
Ensembl chr 6:131,738,356...131,742,685
G
Zc2hc1a
zinc finger, C2HC-type containing 1A
affects expression
EXP
Orphenadrine affects the expression of ZC2HC1A mRNA
CTD
PMID:23665939
NCBI chr 2:94,287,352...94,324,655
Ensembl chr 2:94,287,354...94,324,882
G
Zdhhc8
zinc finger DHHC-type palmitoyltransferase 8
affects expression
EXP
Orphenadrine affects the expression of ZDHHC8 mRNA
CTD
PMID:23665939
NCBI chr11:82,755,110...82,769,280
Ensembl chr11:82,755,143...82,767,734
G
Zfp319
zinc finger protein 319
affects expression
EXP
Orphenadrine affects the expression of ZFP319 mRNA
CTD
PMID:23665939
NCBI chr19:9,702,827...9,706,806
Ensembl chr19:9,702,144...9,713,198
G
Zfp334
zinc finger protein 334
affects expression
EXP
Orphenadrine affects the expression of ZFP334 mRNA
CTD
PMID:23665939
NCBI chr 3:154,112,537...154,125,087
Ensembl chr 3:154,113,561...154,125,057
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Zfp354a
zinc finger protein 354A
affects expression
EXP
Orphenadrine affects the expression of ZFP354A mRNA
CTD
PMID:23665939
NCBI chr10:35,396,242...35,408,069
Ensembl chr10:35,396,231...35,408,068
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Zfp36
zinc finger protein 36
affects expression
EXP
Orphenadrine affects the expression of ZFP36 mRNA
CTD
PMID:23665939
NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
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Zfp36l2
zinc finger protein 36, C3H type-like 2
affects expression
EXP
Orphenadrine affects the expression of ZFP36L2 mRNA
CTD
PMID:23665939
NCBI chr 6:10,490,032...10,494,073
Ensembl chr 6:10,490,032...10,494,064
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Zfp503
zinc finger protein 503
affects expression
EXP
Orphenadrine affects the expression of ZFP503 mRNA
CTD
PMID:23665939
NCBI chr15:2,313,060...2,316,848
Ensembl chr15:2,313,060...2,316,848
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Zfp668
zinc finger protein 668
affects expression
EXP
Orphenadrine affects the expression of ZFP668 mRNA
CTD
PMID:23665939
NCBI chr 1:182,474,633...182,484,957
Ensembl chr 1:182,474,633...182,492,878
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Abcb11
ATP binding cassette subfamily B member 11
decreases activity
ISO
oxybutynin results in decreased activity of ABCB11 protein
CTD
PMID:20829430 PMID:28437613
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
G
Abcb4
ATP binding cassette subfamily B member 4
decreases activity
ISO
oxybutynin results in decreased activity of ABCB4 protein
CTD
PMID:28437613
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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Ces2h
carboxylesterase 2H
increases hydrolysis
ISO
CES2 protein results in increased hydrolysis of oxybutynin
CTD
PMID:9300133
NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
G
Chrm2
cholinergic receptor, muscarinic 2
multiple interactions
ISO
oxybutynin binds to and results in decreased activity of CHRM2 protein
CTD
PMID:15140916
NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
G
Chrm3
cholinergic receptor, muscarinic 3
multiple interactions
ISO
oxybutynin binds to and results in decreased activity of CHRM3 protein
CTD
PMID:15140916
NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278
G
Cyp2c79
cytochrome P450, family 2, subfamily c, polypeptide 79
decreases activity
ISO
oxybutynin results in decreased activity of CYP2C8 protein
CTD
PMID:15601807
G
Drd2
dopamine receptor D2
affects binding
ISO
oxybutynin binds to DRD2 protein
CTD
PMID:10888308
NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
G
Il24
interleukin 24
decreases expression
ISO
oxybutynin results in decreased expression of IL24 mRNA
CTD
PMID:32816093
NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
decreases expression
EXP
oxybutynin results in decreased expression of JUN mRNA
CTD
PMID:10458442
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Met
MET proto-oncogene, receptor tyrosine kinase
decreases expression
ISO
oxybutynin results in decreased expression of MET mRNA
CTD
PMID:32816093
NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
G
Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
oxybutynin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Slpi
secretory leukocyte peptidase inhibitor
increases expression
ISO
oxybutynin results in increased expression of SLPI mRNA
CTD
PMID:32816093
NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
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Ache
acetylcholinesterase
decreases activity
ISO
Pancuronium results in decreased activity of ACHE protein
CTD
PMID:24157926 PMID:25522658
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
G
Chrm1
cholinergic receptor, muscarinic 1
multiple interactions
ISO
Pancuronium inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]
CTD
PMID:9846649
NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356
G
Chrm2
cholinergic receptor, muscarinic 2
multiple interactions
ISO
Pancuronium inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]
CTD
PMID:9846649
NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
G
Chrm3
cholinergic receptor, muscarinic 3
multiple interactions
ISO
Pancuronium inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]
CTD
PMID:9846649
NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278
G
Chrm4
cholinergic receptor, muscarinic 4
multiple interactions
ISO
Pancuronium inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein]
CTD
PMID:9846649
NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159
G
Chrm5
cholinergic receptor, muscarinic 5
multiple interactions
ISO
Pancuronium inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]
CTD
PMID:9846649
NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252
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Chrna3
cholinergic receptor nicotinic alpha 3 subunit
multiple interactions
ISO
Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]
CTD
PMID:16931985
NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165
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Chrna4
cholinergic receptor nicotinic alpha 4 subunit
multiple interactions
ISO
Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Pancuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Pancuronium results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
CTD
PMID:14645658 PMID:16931985
NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
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Chrna7
cholinergic receptor nicotinic alpha 7 subunit
multiple interactions
ISO
Pancuronium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]
CTD
PMID:16931985
NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240
G
Chrnb2
cholinergic receptor nicotinic beta 2 subunit
multiple interactions
ISO
Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Pancuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Pancuronium results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
CTD
PMID:14645658 PMID:16931985
NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
G
Chrnb4
cholinergic receptor nicotinic beta 4 subunit
multiple interactions
ISO
Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]
CTD
PMID:16931985
NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027
G
Ace2
angiotensin converting enzyme 2
decreases expression
ISO
Papaverine results in decreased expression of ACE2 mRNA
CTD
PMID:32808185
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
G
Bdnf
brain-derived neurotrophic factor
increases expression
EXP
Papaverine results in increased expression of BDNF mRNA
CTD
PMID:8601816
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
G
Cftr
CF transmembrane conductance regulator
multiple interactions increases activity
ISO
Papaverine promotes the reaction [CFTR protein affects the secretion of Chlorides] Papaverine results in increased activity of CFTR protein
CTD
PMID:12714375
NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
G
Cldn5
claudin 5
decreases expression
EXP
Papaverine results in decreased expression of CLDN5 protein
CTD
PMID:20728510
NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992
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Creb1
cAMP responsive element binding protein 1
increases expression
EXP
Papaverine results in increased expression of CREB1 mRNA
CTD
PMID:8601816
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions
ISO
Papaverine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
CTD
PMID:18493746
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions
ISO
Papaverine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
CTD
PMID:18493746
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
G
Hamp
hepcidin antimicrobial peptide
decreases expression
ISO
Papaverine results in decreased expression of HAMP mRNA
CTD
PMID:25633564
NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
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Hsf1
heat shock transcription factor 1
increases activity
ISO
Papaverine results in increased activity of HSF1 protein
CTD
PMID:34170685
NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
G
Lipe
lipase E, hormone sensitive type
multiple interactions
EXP
Papaverine inhibits the reaction [Isoproterenol affects the localization of LIPE protein]; Papaverine inhibits the reaction [Isoproterenol results in increased activity of LIPE protein]
CTD
PMID:10894095
NCBI chr 1:80,965,612...80,984,313
Ensembl chr 1:80,965,627...80,984,310
G
Nr1h4
nuclear receptor subfamily 1, group H, member 4
increases activity
ISO
Papaverine results in increased activity of NR1H4 protein
CTD
PMID:22414727
NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
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Ntrk2
neurotrophic receptor tyrosine kinase 2
increases expression
EXP
Papaverine results in increased expression of NTRK2 mRNA
CTD
PMID:8601816
NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
G
Ocln
occludin
decreases expression
EXP
Papaverine results in decreased expression of OCLN protein
CTD
PMID:20728510
NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
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Pde7a
phosphodiesterase 7A
multiple interactions
ISO
Papaverine inhibits the reaction [PDE7A protein results in increased hydrolysis of Cyclic AMP]
CTD
PMID:10618442
NCBI chr 2:101,714,767...101,806,853
Ensembl chr 2:101,718,444...101,806,681
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Pde7b
phosphodiesterase 7B
multiple interactions
ISO
Papaverine inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP]
CTD
PMID:10618442
NCBI chr 1:15,174,001...15,493,267
Ensembl chr 1:15,182,704...15,492,900
G
Slc22a3
solute carrier family 22 member 3
multiple interactions
ISO EXP
Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]
CTD
PMID:9830022 PMID:12411423
NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
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Ces1d
carboxylesterase 1D
affects binding increases hydrolysis
ISO
Meperidine binds to CES1 protein CES1 protein results in increased hydrolysis of Meperidine
CTD
PMID:10381793
NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
G
Ces2h
carboxylesterase 2H
affects binding
ISO
Meperidine binds to CES2 protein
CTD
PMID:10381793
NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
G
Avpr1a
arginine vasopressin receptor 1A
multiple interactions
EXP
Pirenzepine binds to and results in decreased activity of AVPR1A protein
CTD
PMID:11553362
NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215
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Cd40
CD40 molecule
multiple interactions
ISO
Pirenzepine inhibits the reaction [Carbachol results in increased expression of CD40 protein]
CTD
PMID:16879495
NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
G
Chrm1
cholinergic receptor, muscarinic 1
multiple interactions affects binding
ISO EXP
brucine affects the reaction [Pirenzepine analog binds to CHRM1 protein]; Pirenzepine inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]; Pirenzepine inhibits the reaction [Scopolamine Derivatives binds to CHRM1 protein] Pirenzepine binds to and results in decreased activity of CHRM1 protein; Pirenzepine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]
CTD
PMID:8032910 PMID:9846649 PMID:11306684 PMID:12646291 PMID:15294002 PMID:18316702 More...
NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356
G
Chrm5
cholinergic receptor, muscarinic 5
multiple interactions
ISO
Pirenzepine inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]
CTD
PMID:9846649
NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252
G
Egr1
early growth response 1
multiple interactions
EXP
Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA]
CTD
PMID:7968354
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
G
Egr2
early growth response 2
multiple interactions
EXP
Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA]
CTD
PMID:7968354
NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions
EXP
Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]
CTD
PMID:7968354
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
G
Junb
JunB proto-oncogene, AP-1 transcription factor subunit
multiple interactions
EXP
Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA]
CTD
PMID:7968354
NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
G
Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
pridinol results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
G
Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
pridinol inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
G
Abcb1a
ATP binding cassette subfamily B member 1A
affects uptake
ISO
ABCB1 protein affects the uptake of Quinine analog
CTD
PMID:11934808
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
G
Abcb1b
ATP-binding cassette, sub-family B member 1B
affects uptake
EXP
ABCB1B protein affects the uptake of Quinine analog
CTD
PMID:11934808
NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
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App
amyloid beta precursor protein
multiple interactions
ISO
Quinine affects the reaction [APP protein binds to APP protein]
CTD
PMID:18537544
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases activity decreases activity increases expression
ISO
Quinine results in increased activity of CYP1A1 protein Quinine results in decreased activity of CYP1A1 protein Quinine results in increased expression of CYP1A1 mRNA
CTD
PMID:12451431 PMID:33814510
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases expression
ISO
Quinine results in increased expression of CYP1A2 mRNA
CTD
PMID:12451431
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
G
Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
decreases activity
EXP
Quinine results in decreased activity of CYP2C11 protein
CTD
PMID:12814958 PMID:15879494
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
decreases activity
EXP ISO
Quinine results in decreased activity of CYP2C6V1 protein Quinine results in decreased activity of CYP2C19 protein
CTD
PMID:11124226 PMID:12814958 PMID:15879494
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
G
Cyp2d2
cytochrome P450, family 2, subfamily d, polypeptide 2
decreases activity multiple interactions
EXP
Quinine results in decreased activity of CYP2D2 protein Quinine inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin]
CTD
PMID:12814958 PMID:19858067
NCBI chr 7:113,935,138...113,939,209
Ensembl chr 7:113,935,138...113,939,209
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
multiple interactions
EXP
Quinine inhibits the reaction [CYP2D6 protein results in increased oxidation of Chlorpyrifos]
CTD
PMID:14979094
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
decreases activity affects metabolic processing
ISO
Quinine results in decreased activity of CYP3A4 protein CYP3A4 protein affects the metabolism of Quinine
CTD
PMID:11124226 PMID:12920490 PMID:15896247
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
G
Grm1
glutamate metabotropic receptor 1
affects response to substance
EXP
GRM1 protein affects the susceptibility to Quinine
CTD
PMID:19174448
NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170
G
Gstm1
glutathione S-transferase mu 1
decreases activity
ISO
Quinine results in decreased activity of GSTM1 protein
CTD
PMID:11807801
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
G
Gstp1
glutathione S-transferase pi 1
multiple interactions decreases activity
ISO
Quinine inhibits the reaction [GSTP1 protein affects the metabolism of and results in decreased activity of Ethacrynic Acid] Quinine results in decreased activity of GSTP1 protein
CTD
PMID:11807801
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
G
Il1a
interleukin 1 alpha
multiple interactions
ISO
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Quinine
CTD
PMID:19362101
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
G
Il6
interleukin 6
multiple interactions
ISO
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Quinine
CTD
PMID:19362101
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Kcnh2
potassium voltage-gated channel subfamily H member 2
affects response to substance decreases activity
ISO
KCNH2 gene SNP affects the susceptibility to Quinine Quinine results in decreased activity of KCNH2 protein
CTD
PMID:12695533 PMID:28551711
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
G
Kcnk18
potassium two pore domain channel subfamily K member 18
multiple interactions
ISO
Quinine inhibits the reaction [KCNK18 protein results in increased transport of Potassium]
CTD
PMID:12754259
NCBI chr 1:258,374,671...258,388,945
Ensembl chr 1:258,374,671...258,388,945
G
Slc22a1
solute carrier family 22 member 1
multiple interactions increases uptake decreases activity
EXP ISO
Quinine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] SLC22A1 protein results in increased uptake of Quinine [Quinine results in decreased activity of SLC22A1] which results in decreased uptake of abacavir; Quinine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Quinine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Quinine inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium] Quinine results in decreased activity of SLC22A1; Quinine results in decreased activity of SLC22A1 protein
CTD
PMID:16142924 PMID:16263091 PMID:19357179 PMID:25844889 PMID:27504015 PMID:31830554 More...
NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
G
Slc22a2
solute carrier family 22 member 2
multiple interactions decreases activity
ISO
Quinine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Quinine inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Quinine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Quinine inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium] Quinine results in decreased activity of SLC22A2 protein
CTD
PMID:16263091 PMID:19357179 PMID:21599003 PMID:27504015 PMID:31830554
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Slc22a3
solute carrier family 22 member 3
multiple interactions
ISO
Quinine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Quinine inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]
CTD
PMID:16263091 PMID:19357179
NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
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Slc47a1
solute carrier family 47 member 1
multiple interactions
ISO
Quinine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD
PMID:22419765
NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
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Slc47a2
solute carrier family 47 member 2
multiple interactions
ISO
Quinine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD
PMID:22419765
NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
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Slc9a7
solute carrier family 9 member A7
decreases activity
ISO
Quinine results in decreased activity of SLC9A7 protein
CTD
PMID:11279194
NCBI chr X:2,214,064...2,395,052
Ensembl chr X:2,214,441...2,388,012
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Slco1a4
solute carrier organic anion transporter family, member 1a4
decreases activity increases uptake multiple interactions
EXP ISO
Quinine results in decreased activity of SLCO1A4 protein SLCO1A2 protein results in increased uptake of Quinine naringin inhibits the reaction [SLCO1A2 protein results in increased uptake of Quinine]; Quinine inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate] Quinine inhibits the reaction [SLCO1A4 protein results in increased uptake of Digoxin]
CTD
PMID:11883641 PMID:27504015
NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
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Tnf
tumor necrosis factor
multiple interactions
ISO
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Quinine Quinine inhibits the reaction [TNF protein results in increased transport of Potassium]
CTD
PMID:10783394 PMID:19362101
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Chrm1
cholinergic receptor, muscarinic 1
multiple interactions
ISO
rocuronium inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]
CTD
PMID:9846649
NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356
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Chrm2
cholinergic receptor, muscarinic 2
multiple interactions
ISO
rocuronium inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]
CTD
PMID:9846649
NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
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Chrm3
cholinergic receptor, muscarinic 3
multiple interactions
ISO
rocuronium inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]
CTD
PMID:9846649
NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278
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Chrm4
cholinergic receptor, muscarinic 4
multiple interactions
ISO
rocuronium inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein]
CTD
PMID:9846649
NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159
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Chrm5
cholinergic receptor, muscarinic 5
multiple interactions
ISO
rocuronium inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]
CTD
PMID:9846649
NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252
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Chrna3
cholinergic receptor nicotinic alpha 3 subunit
multiple interactions
ISO
rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]
CTD
PMID:16931985
NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165
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Chrna4
cholinergic receptor nicotinic alpha 4 subunit
multiple interactions
ISO
rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
CTD
PMID:16931985
NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
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Chrna7
cholinergic receptor nicotinic alpha 7 subunit
multiple interactions
ISO
rocuronium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]
CTD
PMID:16931985
NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240
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Chrnb2
cholinergic receptor nicotinic beta 2 subunit
multiple interactions
ISO
rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
CTD
PMID:16931985
NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
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Chrnb4
cholinergic receptor nicotinic beta 4 subunit
multiple interactions
ISO
rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]
CTD
PMID:16931985
NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027
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Abcb1a
ATP binding cassette subfamily B member 1A
decreases expression
EXP
Scopolamine results in decreased expression of ABCB1 mRNA
CTD
PMID:12818353
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcg1
ATP binding cassette subfamily G member 1
increases expression
EXP
Scopolamine results in increased expression of ABCG1 mRNA
CTD
PMID:12818353
NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
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Ache
acetylcholinesterase
multiple interactions increases expression affects activity increases activity decreases activity decreases expression affects response to substance increases response to substance
ISO EXP
kangshuai yizhi inhibits the reaction [Scopolamine results in increased activity of ACHE protein] Scopolamine results in increased expression of ACHE mRNA; Scopolamine results in increased expression of ACHE protein Scopolamine affects the activity of ACHE protein Scopolamine results in decreased activity of ACHE protein Ascorbic Acid inhibits the reaction [Scopolamine results in decreased activity of ACHE protein]; Canagliflozin inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Galantamine inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; stevioside inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Vitamin E inhibits the reaction [Scopolamine results in decreased activity of ACHE protein] Scopolamine results in decreased expression of ACHE protein 7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in increased expression of ACHE protein]; acanthoside B inhibits the reaction [Scopolamine results in increased expression of ACHE protein]; ajoene inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; chong-myung-tang inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; dihydroactinidiolide inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Donepezil inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; mangiferin inhibits the reaction [Scopolamine results in decreased expression of ACHE protein]; Piracetam inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Plant Extracts affects the reaction [Scopolamine affects the activity of ACHE protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased expression of ACHE mRNA]; protopanaxadiol inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Serotonin analog inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of ACHE protein] ACHE affects the susceptibility to Scopolamine ACHE protein results in increased susceptibility to Scopolamine
CTD
PMID:11814146 PMID:15301936 PMID:18533140 PMID:18672024 PMID:20673844 PMID:20694781 PMID:20871768 PMID:22426032 PMID:26408985 PMID:26434561 PMID:27717698 PMID:28837785 PMID:29133030 PMID:31077737 PMID:32001261 PMID:34371027 More...
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Adora3
adenosine A3 receptor
multiple interactions
ISO
[N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein] which results in decreased susceptibility to Scopolamine
CTD
PMID:12672554
NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357
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Agt
angiotensinogen
multiple interactions
ISO
[AGT protein modified form binds to and results in decreased activity of LNPEP protein] which results in decreased susceptibility to Scopolamine
CTD
PMID:11707427
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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Apba1
amyloid beta precursor protein binding family A member 1
increases expression
EXP
Scopolamine results in increased expression of APBA1 mRNA
CTD
PMID:12818353
NCBI chr 1:221,363,769...221,569,496
Ensembl chr 1:221,363,778...221,566,553
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Aplp2
amyloid beta precursor like protein 2
increases expression
EXP
Scopolamine results in increased expression of APLP2 mRNA
CTD
PMID:12818353
NCBI chr 8:29,599,230...29,662,311
Ensembl chr 8:29,599,230...29,661,855
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App
amyloid beta precursor protein
decreases cleavage
ISO
Scopolamine results in decreased cleavage of APP protein
CTD
PMID:16423497
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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Arc
activity-regulated cytoskeleton-associated protein
decreases expression decreases expression
EXP ISO
Scopolamine results in decreased expression of ARC mRNA scopolamine decreases expression of Arc mRNA and protein in cerebral cortex and hippocampus
CTD RGD
PMID:17540011 PMID:24012642
RGD:401938610
NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378
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Arg2
arginase 2
decreases expression
EXP
Scopolamine results in decreased expression of ARG2 mRNA
CTD
PMID:12818353
NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378
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Arl4d
ADP-ribosylation factor like GTPase 4D
decreases expression
EXP
Scopolamine results in decreased expression of ARL4D mRNA
CTD
PMID:17540011
NCBI chr10:86,592,054...86,602,843
Ensembl chr10:86,595,661...86,602,836
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Avp
arginine vasopressin
multiple interactions
EXP
[[[AVP binds to and results in increased activity of AVPR1A protein] which results in increased abundance of Calcium] which results in increased activity of CHRM1 protein] which results in decreased susceptibility to Scopolamine
CTD
PMID:11553362
NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
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Avpr1a
arginine vasopressin receptor 1A
multiple interactions
EXP
[[[AVP binds to and results in increased activity of AVPR1A protein] which results in increased abundance of Calcium] which results in increased activity of CHRM1 protein] which results in decreased susceptibility to Scopolamine
CTD
PMID:11553362
NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215
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Bax
BCL2 associated X, apoptosis regulator
increases expression multiple interactions
ISO
Scopolamine results in increased expression of BAX mRNA; Scopolamine results in increased expression of BAX protein dihydroactinidiolide inhibits the reaction [Scopolamine results in increased expression of BAX protein]; Donepezil inhibits the reaction [Scopolamine results in increased expression of BAX protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased expression of BAX mRNA]
CTD
PMID:17120751 PMID:26434561 PMID:34371027
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcat1
branched chain amino acid transaminase 1
increases expression
EXP
Scopolamine results in increased expression of BCAT1 mRNA
CTD
PMID:17540011
NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597
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Bcl2
BCL2, apoptosis regulator
decreases expression multiple interactions
ISO
Scopolamine results in decreased expression of BCL2 mRNA; Scopolamine results in decreased expression of BCL2 protein dihydroactinidiolide inhibits the reaction [Scopolamine results in decreased expression of BCL2 protein]; Donepezil inhibits the reaction [Scopolamine results in decreased expression of BCL2 protein]
CTD
PMID:17120751 PMID:26434561 PMID:34371027
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bdnf
brain-derived neurotrophic factor
multiple interactions decreases expression
EXP ISO
Scopolamine inhibits the reaction [Dizocilpine Maleate affects the expression of BDNF mRNA]; Scopolamine inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA] Scopolamine results in decreased expression of BDNF mRNA; Scopolamine results in decreased expression of BDNF protein [acanthoside B co-treated with Scopolamine] results in increased expression of BDNF protein; [Tacrine co-treated with Scopolamine] results in increased expression of BDNF protein; Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of BDNF mRNA]; Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]; dihydroactinidiolide inhibits the reaction [Scopolamine results in decreased expression of BDNF mRNA]; Donepezil inhibits the reaction [Scopolamine results in decreased expression of BDNF mRNA]; Melatonin inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]; Plant Extracts inhibits the reaction [Scopolamine results in decreased expression of BDNF mRNA]; Serotonin analog inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]; Tacrine inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]
CTD
PMID:8405262 PMID:8635431 PMID:22096544 PMID:26408985 PMID:26434561 PMID:29476728 PMID:31077737 PMID:34371027 More...
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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Cacna1d
calcium voltage-gated channel subunit alpha1 D
increases expression
EXP
Scopolamine results in increased expression of CACNA1D mRNA
CTD
PMID:12818353
NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215
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Camkk2
calcium/calmodulin-dependent protein kinase kinase 2
decreases expression
EXP
Scopolamine results in decreased expression of CAMKK2 mRNA
CTD
PMID:17540011
NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279
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Cartpt
CART prepropeptide
decreases expression
EXP
Scopolamine results in decreased expression of CARTPT mRNA
CTD
PMID:17540011
NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713
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Casp3
caspase 3
increases expression increases activity multiple interactions
ISO
Scopolamine results in increased expression of CASP3 mRNA; Scopolamine results in increased expression of CASP3 protein Scopolamine results in increased activity of CASP3 protein dihydroactinidiolide inhibits the reaction [Scopolamine results in increased activity of CASP3 protein]; Donepezil inhibits the reaction [Scopolamine results in increased activity of CASP3 protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased expression of CASP3 mRNA]
CTD
PMID:17120751 PMID:26434561 PMID:34371027
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cat
catalase
multiple interactions increases activity decreases activity
ISO
acanthoside B inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; chong-myung-tang inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; dihydroactinidiolide inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; Donepezil inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; Piracetam inhibits the reaction [Scopolamine results in increased activity of CAT protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased activity of CAT protein]; Tacrine inhibits the reaction [Scopolamine results in decreased activity of CAT protein]
CTD
PMID:20673844 PMID:27717698 PMID:31077737 PMID:34371027
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cd3e
CD3 epsilon subunit of T-cell receptor complex
decreases expression
EXP
Scopolamine results in decreased expression of CD3E mRNA
CTD
PMID:17540011
NCBI chr 8:45,303,848...45,315,005
Ensembl chr 8:45,303,852...45,315,022
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Cdkl4
cyclin-dependent kinase-like 4
increases expression
EXP
Scopolamine results in increased expression of CDKL4 mRNA
CTD
PMID:17540011
NCBI chr 6:14,449,822...14,492,568
Ensembl chr 6:14,450,681...14,492,046
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Chat
choline O-acetyltransferase
decreases activity multiple interactions
ISO
Scopolamine results in decreased activity of CHAT protein protopanaxadiol inhibits the reaction [Scopolamine results in decreased activity of CHAT protein]; Serotonin analog inhibits the reaction [Scopolamine results in decreased activity of CHAT protein] kangshuai yizhi inhibits the reaction [Scopolamine results in decreased activity of CHAT protein]
CTD
PMID:20694781 PMID:26408985 PMID:29133030
NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093
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Chrm1
cholinergic receptor, muscarinic 1
multiple interactions decreases expression increases expression
EXP ISO
[[[AVP binds to and results in increased activity of AVPR1A protein] which results in increased abundance of Calcium] which results in increased activity of CHRM1 protein] which results in decreased susceptibility to Scopolamine; Canagliflozin affects the reaction [Scopolamine results in decreased expression of CHRM1 protein] Scopolamine results in increased expression of CHRM1 mRNA 7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in decreased expression of CHRM1 protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased expression of CHRM1 mRNA]
CTD
PMID:11553362 PMID:26434561 PMID:28837785 PMID:32001261
NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356
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Chrm4
cholinergic receptor, muscarinic 4
increases response to substance
ISO
CHRM4 protein results in increased susceptibility to Scopolamine
CTD
PMID:12729838
NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159
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Chrm5
cholinergic receptor, muscarinic 5
decreases response to substance
ISO
CHRM5 protein results in decreased susceptibility to Scopolamine
CTD
PMID:13679217
NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252
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Chrna4
cholinergic receptor nicotinic alpha 4 subunit
affects binding multiple interactions
ISO
Scopolamine binds to [CHRNA4 protein binds to CHRNB2 protein] Scopolamine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
CTD
PMID:15733544
NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
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Chrnb2
cholinergic receptor nicotinic beta 2 subunit
affects binding multiple interactions
ISO
Scopolamine binds to [CHRNA4 protein binds to CHRNB2 protein] Scopolamine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
CTD
PMID:15733544
NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
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Coch
cochlin
decreases expression
EXP
Scopolamine results in decreased expression of COCH mRNA
CTD
PMID:12818353
NCBI chr 6:69,031,139...69,045,124
Ensembl chr 6:69,031,167...69,045,109
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Coro1b
coronin 1B
increases expression
EXP
Scopolamine results in increased expression of CORO1B mRNA
CTD
PMID:12818353
NCBI chr 1:201,442,977...201,448,416
Ensembl chr 1:201,443,014...201,448,416
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Cox5b
cytochrome c oxidase subunit 5B
increases expression
EXP
Scopolamine results in increased expression of COX5B mRNA
CTD
PMID:12818353
NCBI chr 9:38,921,980...38,923,806
Ensembl chr 9:38,921,967...38,925,052
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Creb1
cAMP responsive element binding protein 1
decreases phosphorylation multiple interactions
ISO
Scopolamine results in decreased phosphorylation of CREB1 protein acanthoside B inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein]; Serotonin analog inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein]; Tacrine inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein]
CTD
PMID:26408985 PMID:31077737
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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Cryab
crystallin, alpha B
increases expression
EXP
Scopolamine results in increased expression of CRYAB mRNA
CTD
PMID:17540011
NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
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Csf2
colony stimulating factor 2
multiple interactions decreases response to substance
ISO
IL1RN protein inhibits the reaction [CSF2 protein results in decreased susceptibility to Scopolamine]
CTD
PMID:8877002
NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
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Cxcr5
C-X-C motif chemokine receptor 5
decreases expression
EXP
Scopolamine results in decreased expression of CXCR5 mRNA
CTD
PMID:12818353
NCBI chr 8:44,842,098...44,858,425
Ensembl chr 8:44,843,413...44,857,893
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Ddc
dopa decarboxylase
decreases expression
EXP
Scopolamine results in decreased expression of DDC mRNA
CTD
PMID:17540011
NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
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Dguok
deoxyguanosine kinase
increases expression
EXP
Scopolamine results in increased expression of DGUOK mRNA
CTD
PMID:17540011
NCBI chr 4:115,987,101...116,014,733
Ensembl chr 4:115,979,094...116,014,733
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Dio2
iodothyronine deiodinase 2
increases expression
EXP
Scopolamine results in increased expression of DIO2 mRNA
CTD
PMID:12818353
NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
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Dusp5
dual specificity phosphatase 5
decreases expression
EXP
Scopolamine results in decreased expression of DUSP5 mRNA
CTD
PMID:17540011
NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818
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Dusp6
dual specificity phosphatase 6
decreases expression
EXP
Scopolamine results in decreased expression of DUSP6 mRNA
CTD
PMID:17540011
NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
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Egfr
epidermal growth factor receptor
decreases expression
EXP
Scopolamine results in decreased expression of EGFR mRNA
CTD
PMID:12818353
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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Egr1
early growth response 1
multiple interactions decreases expression
EXP ISO
[Scopolamine co-treated with 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine] results in increased expression of EGR1 mRNA; Scopolamine affects the reaction [SK&F 82958 results in increased expression of EGR1 mRNA] Donepezil inhibits the reaction [Scopolamine results in decreased expression of EGR1 protein]; protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of EGR1 protein] Scopolamine results in decreased expression of EGR1 mRNA
CTD
PMID:8861055 PMID:17540011 PMID:29133030
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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Egr2
early growth response 2
decreases expression
EXP
Scopolamine results in decreased expression of EGR2 mRNA
CTD
PMID:17540011
NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562
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Eif2s1
eukaryotic translation initiation factor 2 subunit alpha
increases expression
EXP
Scopolamine results in increased expression of EIF2S1 mRNA
CTD
PMID:12818353
NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
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Eml1
EMAP like 1
decreases expression
EXP
Scopolamine results in decreased expression of EML1 mRNA
CTD
PMID:17540011
NCBI chr 6:127,283,968...127,457,246
Ensembl chr 6:127,284,029...127,457,246
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions decreases expression increases expression
EXP ISO
[Scopolamine co-treated with 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine] results in increased expression of FOS mRNA; Physostigmine inhibits the reaction [Scopolamine promotes the reaction [SK&F 82958 results in increased expression of FOS mRNA]]; Ro4368554 inhibits the reaction [Scopolamine results in increased expression of FOS protein]; Scopolamine affects the reaction [SK&F 82958 results in increased expression of FOS mRNA]; Scopolamine inhibits the reaction [Haloperidol results in increased expression of FOS protein]; Scopolamine promotes the reaction [SK&F 82958 results in increased expression of FOS mRNA] Donepezil inhibits the reaction [Scopolamine results in decreased expression of FOS protein]; protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of FOS protein] Scopolamine results in decreased expression of FOS mRNA
CTD
PMID:1393566 PMID:8281324 PMID:8861055 PMID:11337201 PMID:17540011 PMID:17920665 PMID:29133030 More...
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Gabbr1
gamma-aminobutyric acid type B receptor subunit 1
increases expression
EXP
Scopolamine results in increased expression of GABBR1 mRNA
CTD
PMID:17540011
NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994
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Gap43
growth associated protein 43
decreases expression multiple interactions
ISO
Scopolamine results in decreased expression of GAP43 protein Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of GAP43 protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of GAP43 protein]
CTD
PMID:22096544
NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045
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Gfap
glial fibrillary acidic protein
multiple interactions decreases expression
ISO
Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of GFAP mRNA]; Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of GFAP protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of GFAP protein] Scopolamine results in decreased expression of GFAP mRNA; Scopolamine results in decreased expression of GFAP protein
CTD
PMID:22096544
NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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Gjb2
gap junction protein, beta 2
increases expression
EXP
Scopolamine results in increased expression of GJB2 mRNA
CTD
PMID:17540011
NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177
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Gpc3
glypican 3
decreases expression
EXP
Scopolamine results in decreased expression of GPC3 mRNA
CTD
PMID:12818353
NCBI chr X:131,868,986...132,236,824
Ensembl chr X:131,868,990...132,236,798
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Grm4
glutamate metabotropic receptor 4
multiple interactions
ISO
Scopolamine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]
CTD
PMID:18171729
NCBI chr20:5,484,172...5,572,821
Ensembl chr20:5,481,124...5,572,821
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Gsr
glutathione-disulfide reductase
decreases activity multiple interactions
ISO
Scopolamine results in decreased activity of GSR protein Serotonin analog inhibits the reaction [Scopolamine results in decreased activity of GSR protein]; Tacrine inhibits the reaction [Scopolamine results in decreased activity of GSR protein]
CTD
PMID:26408985
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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Gypc
glycophorin C
decreases expression
EXP
Scopolamine results in decreased expression of GYPC mRNA
CTD
PMID:17540011
NCBI chr18:24,160,738...24,193,408
Ensembl chr18:24,160,739...24,193,204
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Hmox1
heme oxygenase 1
multiple interactions increases expression
ISO
7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in increased expression of HMOX1 protein]
CTD
PMID:32001261
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Homer1
homer scaffold protein 1
decreases expression
EXP
Scopolamine results in decreased expression of HOMER1 mRNA
CTD
PMID:17540011
NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785
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Hrh1
histamine receptor H 1
multiple interactions
EXP
[Histamine binds to and results in increased activity of HRH1 protein] which results in decreased susceptibility to Scopolamine; Pyrilamine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in decreased susceptibility to Scopolamine]
CTD
PMID:19215234
NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455
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Hrh2
histamine receptor H 2
multiple interactions
EXP
[[thioperamide results in increased abundance of Histamine] which results in increased activity of HRH2 protein] which results in decreased susceptibility to Scopolamine; Cimetidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in decreased susceptibility to Scopolamine]
CTD
PMID:11640976 PMID:19215234
NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631
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Hrh3
histamine receptor H3
multiple interactions
EXP
[clobenpropit binds to and results in decreased activity of HRH3 protein] which results in decreased susceptibility to Scopolamine
CTD
PMID:16488453
NCBI chr 3:167,191,551...167,196,642
Ensembl chr 3:167,191,558...167,196,642
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Hspa2
heat shock protein family A (Hsp70) member 2
increases expression
EXP
Scopolamine results in increased expression of HSPA2 mRNA
CTD
PMID:12818353
NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287
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Htr1a
5-hydroxytryptamine receptor 1A
multiple interactions
EXP
[4-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine binds to and results in increased activity of HTR1A] which results in decreased susceptibility to Scopolamine; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [[4-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine binds to and results in increased activity of HTR1A] which results in decreased susceptibility to Scopolamine]
CTD
PMID:10578133
NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442
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Htr2c
5-hydroxytryptamine receptor 2C
increases expression
EXP
Scopolamine results in increased expression of HTR2C mRNA
CTD
PMID:17540011
NCBI chr X:110,640,777...110,870,288
Ensembl chr X:110,641,153...110,870,287
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Htr6
5-hydroxytryptamine receptor 6
decreases expression
EXP
Scopolamine results in decreased expression of HTR6 mRNA
CTD
PMID:19733250
NCBI chr 5:151,295,269...151,312,853
Ensembl chr 5:151,296,662...151,311,912
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Ifng
interferon gamma
multiple interactions increases expression
EXP
Fatty Acids, Unsaturated deficiency promotes the reaction [Scopolamine results in increased expression of IFNG mRNA]
CTD
PMID:21161262
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il10
interleukin 10
decreases expression multiple interactions
ISO
Scopolamine results in decreased expression of IL10 protein acanthoside B inhibits the reaction [Scopolamine results in decreased expression of IL10 protein]; Tacrine inhibits the reaction [Scopolamine results in decreased expression of IL10 protein]
CTD
PMID:31077737
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il1a
interleukin 1 alpha
decreases response to substance
ISO
IL1A protein results in decreased susceptibility to Scopolamine
CTD
PMID:8003924
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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Il1b
interleukin 1 beta
increases expression multiple interactions
ISO EXP
Scopolamine results in increased expression of IL1B mRNA; Scopolamine results in increased expression of IL1B protein Fatty Acids, Unsaturated deficiency promotes the reaction [Scopolamine results in increased expression of IL1B mRNA] acanthoside B inhibits the reaction [Scopolamine results in increased expression of IL1B protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of IL1B protein]; timosaponin AIII inhibits the reaction [Scopolamine results in increased expression of IL1B protein]
CTD
PMID:18357464 PMID:19426756 PMID:21161262 PMID:31077737
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il1rn
interleukin 1 receptor antagonist
multiple interactions
ISO
IL1RN protein inhibits the reaction [CSF2 protein results in decreased susceptibility to Scopolamine]
CTD
PMID:8877002
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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Il6
interleukin 6
multiple interactions increases expression
EXP ISO
Fatty Acids, Unsaturated deficiency promotes the reaction [Scopolamine results in increased expression of IL6 mRNA]; Scopolamine promotes the reaction [Fatty Acids, Unsaturated deficiency results in increased expression of IL6 mRNA] acanthoside B inhibits the reaction [Scopolamine results in increased expression of IL6 protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of IL6 protein] Scopolamine results in increased expression of IL6 mRNA; Scopolamine results in increased expression of IL6 protein
CTD
PMID:18357464 PMID:21161262 PMID:31077737
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Itpr1
inositol 1,4,5-trisphosphate receptor, type 1
increases expression
EXP
Scopolamine results in increased expression of ITPR1 mRNA
CTD
PMID:12818353
NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
multiple interactions decreases expression
EXP ISO
Physostigmine inhibits the reaction [Scopolamine promotes the reaction [SK&F 82958 results in increased expression of JUN mRNA]]; Scopolamine promotes the reaction [SK&F 82958 results in increased expression of JUN mRNA] Scopolamine results in decreased expression of JUN protein Donepezil inhibits the reaction [Scopolamine results in decreased expression of JUN protein]; protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of JUN protein]
CTD
PMID:11337201 PMID:29133030
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Junb
JunB proto-oncogene, AP-1 transcription factor subunit
decreases expression
EXP
Scopolamine results in decreased expression of JUNB mRNA
CTD
PMID:17540011
NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
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Kcna4
potassium voltage-gated channel subfamily A member 4
increases expression
EXP
Scopolamine results in increased expression of KCNA4 mRNA
CTD
PMID:12579815
NCBI chr 3:93,756,399...93,778,004
Ensembl chr 3:93,756,446...93,769,162
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Kcnb1
potassium voltage-gated channel subfamily B member 1
increases expression
EXP
Scopolamine results in increased expression of KCNB1 mRNA
CTD
PMID:12579815 PMID:15567561
NCBI chr 3:155,820,255...155,913,383
Ensembl chr 3:155,822,963...155,916,194
G
Kcnd2
potassium voltage-gated channel subfamily D member 2
decreases expression
EXP
Scopolamine results in decreased expression of KCND2 mRNA
CTD
PMID:12579815
NCBI chr 4:49,775,812...50,277,746
Ensembl chr 4:49,776,246...50,277,728
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Kcnj3
potassium inwardly-rectifying channel, subfamily J, member 3
multiple interactions
ISO
Scopolamine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]
CTD
PMID:18171729
NCBI chr 3:39,944,896...40,106,646
Ensembl chr 3:39,945,351...40,109,124
G
Klf2
KLF transcription factor 2
decreases expression
EXP
Scopolamine results in decreased expression of KLF2 mRNA
CTD
PMID:17540011
NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944
G
Klf4
KLF transcription factor 4
decreases expression
EXP
Scopolamine results in decreased expression of KLF4 mRNA
CTD
PMID:17540011
NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
G
Lnpep
leucyl and cystinyl aminopeptidase
multiple interactions
ISO
[AGT protein modified form binds to and results in decreased activity of LNPEP protein] which results in decreased susceptibility to Scopolamine
CTD
PMID:11707427
NCBI chr 1:58,258,642...58,355,532
Ensembl chr 1:58,258,642...58,354,544
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Madd
MAP-kinase activating death domain
increases expression
EXP
Scopolamine results in increased expression of MADD mRNA
CTD
PMID:12818353
NCBI chr 3:77,114,330...77,157,865
Ensembl chr 3:77,114,314...77,157,701
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Map2
microtubule-associated protein 2
decreases expression multiple interactions
ISO
Scopolamine results in decreased expression of MAP2 protein Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of MAP2 protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of MAP2 protein]
CTD
PMID:22096544
NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
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Mapt
microtubule-associated protein tau
decreases expression
EXP
Scopolamine results in decreased expression of MAPT mRNA
CTD
PMID:12818353
NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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Mbp
myelin basic protein
decreases expression multiple interactions
ISO
Scopolamine results in decreased expression of MBP protein Melatonin inhibits the reaction [Scopolamine results in decreased expression of MBP protein]
CTD
PMID:29476728
NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
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Muc5ac
mucin 5AC, oligomeric mucus/gel-forming
decreases expression
ISO EXP
Scopolamine results in decreased expression of MUC5AC protein
CTD
PMID:18357464 PMID:21161262
NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
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Nefh
neurofilament heavy chain
multiple interactions decreases expression
ISO
Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of NEFH protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of NEFH protein]
CTD
PMID:22096544
NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
G
Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions decreases expression
ISO
7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in decreased expression of NFE2L2 protein]
CTD
PMID:32001261
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
G
Ngf
nerve growth factor
decreases response to substance multiple interactions increases response to substance
EXP ISO
NGF protein results in decreased susceptibility to Scopolamine Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NGF mRNA] NGF protein results in increased susceptibility to Scopolamine
CTD
PMID:1661212 PMID:8635431 PMID:16405025
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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Nos2
nitric oxide synthase 2
multiple interactions increases expression
ISO
acanthoside B inhibits the reaction [Scopolamine results in increased expression of NOS2 protein]; Serotonin analog inhibits the reaction [Scopolamine results in increased expression of NOS2 protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of NOS2 protein]
CTD
PMID:26408985 PMID:31077737
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
G
Nova1
NOVA alternative splicing regulator 1
multiple interactions
EXP
Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NOVA1 mRNA]
CTD
PMID:20470870
NCBI chr 6:63,780,105...63,905,567
Ensembl chr 6:63,783,489...63,906,289
G
Nova2
NOVA alternative splicing regulator 2
multiple interactions
EXP
Scopolamine inhibits the reaction [Pilocarpine results in decreased expression of NOVA2 mRNA]
CTD
PMID:20470870
NCBI chr 1:78,572,253...78,613,703
Ensembl chr 1:78,572,279...78,608,021
G
Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions decreases expression
ISO
Serotonin analog inhibits the reaction [Scopolamine results in decreased expression of NQO1 protein]
CTD
PMID:26408985
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
G
Nqo2
N-ribosyldihydronicotinamide:quinone dehydrogenase 2
increases expression
EXP
Scopolamine results in increased expression of NQO2 mRNA
CTD
PMID:20861374
NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320
G
Nr1d1
nuclear receptor subfamily 1, group D, member 1
decreases expression
EXP
Scopolamine results in decreased expression of NR1D1 mRNA
CTD
PMID:17540011
NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705
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Nr4a1
nuclear receptor subfamily 4, group A, member 1
decreases expression
EXP
Scopolamine results in decreased expression of NR4A1 mRNA
CTD
PMID:17540011
NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
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Ntf3
neurotrophin 3
multiple interactions
EXP
Scopolamine inhibits the reaction [Pilocarpine results in decreased expression of NTF3 mRNA]
CTD
PMID:8635431
NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596
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Ntrk2
neurotrophic receptor tyrosine kinase 2
multiple interactions decreases expression
EXP ISO
Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NTRK2 mRNA] Scopolamine results in decreased expression of NTRK2 protein [acanthoside B co-treated with Scopolamine] results in increased phosphorylation of NTRK2 protein; [Tacrine co-treated with Scopolamine] results in increased phosphorylation of NTRK2 protein; Melatonin inhibits the reaction [Scopolamine results in decreased expression of NTRK2 protein]
CTD
PMID:8635431 PMID:29476728 PMID:31077737
NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
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Ntrk3
neurotrophic receptor tyrosine kinase 3
multiple interactions
EXP
Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NTRK3 mRNA]
CTD
PMID:8635431
NCBI chr 1:132,116,472...132,503,849
Ensembl chr 1:132,132,849...132,503,286
G
Pdcd4
programmed cell death 4
increases expression
EXP
Scopolamine results in increased expression of PDCD4 mRNA
CTD
PMID:12818353
NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275
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Pdyn
prodynorphin
decreases response to substance multiple interactions increases expression
ISO EXP
PDYN protein modified form results in decreased susceptibility to Scopolamine MR 2266 inhibits the reaction [PDYN protein modified form results in decreased susceptibility to Scopolamine] Scopolamine results in increased expression of PDYN mRNA
CTD
PMID:7768285 PMID:17540011
NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334
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Penk
proenkephalin
multiple interactions
EXP
Scopolamine inhibits the reaction [Haloperidol results in increased expression of PENK mRNA]
CTD
PMID:7637876
NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
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Pgam1
phosphoglycerate mutase 1
decreases expression
EXP
Scopolamine results in decreased expression of PGAM1 mRNA
CTD
PMID:12818353
NCBI chr 1:240,723,832...240,731,443
Ensembl chr 1:240,723,920...240,738,452
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Prep
prolyl endopeptidase
increases response to substance increases expression multiple interactions
EXP
PREP protein results in increased susceptibility to Scopolamine Scopolamine results in increased expression of PREP protein Piracetam inhibits the reaction [Scopolamine results in increased expression of PREP protein]
CTD
PMID:17244263 PMID:18318186
NCBI chr20:48,556,211...48,653,165
Ensembl chr20:48,556,280...48,654,466
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Prkra
protein activator of interferon induced protein kinase EIF2AK2
decreases expression
EXP
Scopolamine results in decreased expression of PRKRA mRNA
CTD
PMID:12818353
NCBI chr 3:61,575,447...61,594,393
Ensembl chr 3:61,575,447...61,594,347
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Psen2
presenilin 2
decreases expression
EXP
Scopolamine results in decreased expression of PSEN2 mRNA
CTD
PMID:12818353
NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174
G
Ptgs2
prostaglandin-endoperoxide synthase 2
increases expression multiple interactions
ISO
Scopolamine results in increased expression of PTGS2 protein acanthoside B inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein]; Serotonin analog inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein]
CTD
PMID:26408985 PMID:31077737
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Rab14
RAB14, member RAS oncogene family
increases expression
EXP
Scopolamine results in increased expression of RAB14 mRNA
CTD
PMID:17540011
NCBI chr 3:18,501,953...18,523,253
Ensembl chr 3:18,501,963...18,523,172
G
Rapgef3
Rap guanine nucleotide exchange factor 3
decreases expression
EXP
Scopolamine results in decreased expression of RAPGEF3 mRNA
CTD
PMID:12818353
NCBI chr 7:128,875,772...128,898,203
Ensembl chr 7:128,875,773...128,898,521
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
mangiferin inhibits the reaction [Scopolamine results in increased phosphorylation of and results in increased activity of RELA protein]; Scopolamine results in increased phosphorylation of and results in increased activity of RELA protein; timosaponin AIII inhibits the reaction [Scopolamine results in increased phosphorylation of and results in increased activity of RELA protein]
CTD
PMID:19182383 PMID:19426756
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Rem2
RRAD and GEM like GTPase 2
decreases expression
EXP
Scopolamine results in decreased expression of REM2 mRNA
CTD
PMID:17540011
NCBI chr15:27,933,950...27,938,429
Ensembl chr15:27,933,950...27,938,429
G
Rgs7bp
regulator of G-protein signaling 7 binding protein
decreases expression
EXP
Scopolamine results in decreased expression of RGS7BP mRNA
CTD
PMID:17540011
NCBI chr 2:36,133,944...36,231,505
Ensembl chr 2:36,139,201...36,231,505
G
Robo3
roundabout guidance receptor 3
decreases expression
EXP
Scopolamine results in decreased expression of ROBO3 mRNA
CTD
PMID:17540011
NCBI chr 8:37,133,542...37,151,674
Ensembl chr 8:37,133,916...37,151,315
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Rraga
Ras-related GTP binding A
increases expression
EXP
Scopolamine results in increased expression of RRAGA mRNA
CTD
PMID:12818353
NCBI chr 5:101,113,341...101,114,936
Ensembl chr 5:101,112,859...101,114,510
G
S100a4
S100 calcium-binding protein A4
decreases expression
EXP
Scopolamine results in decreased expression of S100A4 mRNA
CTD
PMID:17540011
NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
G
S1pr1
sphingosine-1-phosphate receptor 1
increases expression
EXP
Scopolamine results in increased expression of S1PR1 mRNA
CTD
PMID:12818353
NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681
G
Scamp2
secretory carrier membrane protein 2
increases expression
EXP
Scopolamine results in increased expression of SCAMP2 mRNA
CTD
PMID:12818353
NCBI chr 8:57,965,612...57,992,248
Ensembl chr 8:57,965,631...57,992,646
G
Sigmar1
sigma non-opioid intracellular receptor 1
multiple interactions
ISO
[2-(4-morpholino)ethyl-1-phenylcyclohexane-1-carboxylate binds to and results in increased activity of SIGMAR1 protein] which results in decreased susceptibility to Scopolamine; [igmesine binds to and results in increased activity of SIGMAR1 protein] which results in decreased susceptibility to Scopolamine
CTD
PMID:12028363
NCBI chr 5:56,904,155...56,907,012
Ensembl chr 5:56,904,159...56,907,017
G
Slc47a1
solute carrier family 47 member 1
multiple interactions
ISO
Scopolamine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD
PMID:22419765
NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
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Slc47a2
solute carrier family 47 member 2
multiple interactions
ISO
Scopolamine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD
PMID:22419765
NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
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Sult1a1
sulfotransferase family 1A member 1
increases expression
EXP
Scopolamine results in increased expression of SULT1A1 mRNA
CTD
PMID:17540011
NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
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Syp
synaptophysin
multiple interactions decreases expression increases expression
EXP ISO
cyclo-L-glycyl-L-2-allylproline inhibits the reaction [Scopolamine results in increased expression of SYP protein] dihydroactinidiolide inhibits the reaction [Scopolamine results in decreased expression of SYP mRNA]; Donepezil inhibits the reaction [Scopolamine results in decreased expression of SYP mRNA]
CTD
PMID:20188767 PMID:34371027
NCBI chr X:14,849,444...14,864,553
Ensembl chr X:14,849,444...14,864,745
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Tac1
tachykinin, precursor 1
decreases response to substance
EXP
TAC1 protein modified form results in decreased susceptibility to Scopolamine
CTD
PMID:20600432
NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
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Tnf
tumor necrosis factor
multiple interactions increases expression
ISO EXP
acanthoside B inhibits the reaction [Scopolamine results in increased expression of TNF protein]; mangiferin inhibits the reaction [Scopolamine results in increased expression of TNF protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of TNF protein]; timosaponin AIII inhibits the reaction [Scopolamine results in increased expression of TNF protein] Scopolamine results in increased expression of TNF mRNA Scopolamine results in increased expression of TNF mRNA; Scopolamine results in increased expression of TNF protein
CTD
PMID:18357464 PMID:19182383 PMID:19426756 PMID:21161262 PMID:31077737
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnrc6a
trinucleotide repeat containing adaptor 6A
decreases expression
EXP
Scopolamine results in decreased expression of TNRC6A mRNA
CTD
PMID:17540011
NCBI chr 1:177,561,898...177,715,669
Ensembl chr 1:177,646,030...177,715,660
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Tpd52l1
TPD52 like 1
increases expression
EXP
Scopolamine results in increased expression of TPD52L1 mRNA
CTD
PMID:17540011
NCBI chr 1:26,172,038...26,290,704
Ensembl chr 1:26,172,170...26,291,109
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Vgf
VGF nerve growth factor inducible
decreases expression
EXP
Scopolamine results in decreased expression of VGF mRNA
CTD
PMID:17540011
NCBI chr12:19,637,313...19,645,123
Ensembl chr12:19,637,320...19,640,341
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Vip
vasoactive intestinal peptide
decreases response to substance
EXP
VIP protein results in decreased susceptibility to Scopolamine
CTD
PMID:8208360
NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216
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Bche
butyrylcholinesterase
increases response to substance increases metabolic processing increases hydrolysis affects hydrolysis multiple interactions decreases abundance decreases hydrolysis affects response to substance
ISO
BCHE gene mutant form results in increased susceptibility to Succinylcholine; BCHE gene polymorphism results in increased susceptibility to Succinylcholine; BCHE protein mutant form results in increased susceptibility to Succinylcholine BCHE protein results in increased metabolism of Succinylcholine BCHE protein results in increased hydrolysis of Succinylcholine BCHE protein mutant form affects the hydrolysis of Succinylcholine [Dichlorvos results in decreased activity of BCHE protein] which results in increased susceptibility to Succinylcholine; Insecticides inhibits the reaction [BCHE protein results in increased metabolism of Succinylcholine]; Organophosphorus Compounds inhibits the reaction [BCHE protein results in increased metabolism of Succinylcholine]; Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine] BCHE protein results in decreased abundance of Succinylcholine BCHE protein mutant form results in decreased hydrolysis of Succinylcholine BCHE affects the susceptibility to Succinylcholine; BCHE gene mutant form affects the susceptibility to Succinylcholine; BCHE gene polymorphism affects the susceptibility to Succinylcholine; BCHE protein affects the susceptibility to Succinylcholine
CTD
PMID:726855 PMID:900467 PMID:987736 PMID:1058931 PMID:1147298 PMID:1218148 PMID:1218179 PMID:1734774 PMID:1781528 PMID:2249680 PMID:2432808 PMID:4319258 PMID:4698763 PMID:4728581 PMID:4746059 PMID:4850696 PMID:4985882 PMID:4998912 PMID:5365519 PMID:5412891 PMID:5488351 PMID:5673118 PMID:6465587 PMID:6859614 PMID:6928942 PMID:7069741 PMID:7294376 PMID:7378868 PMID:7793179 PMID:8179139 PMID:9110359 PMID:12190811 PMID:12881446 PMID:15688329 PMID:15826794 PMID:16788378 PMID:16884476 PMID:18075469 PMID:18399847 PMID:18555211 PMID:21029050 PMID:21228368 PMID:25054547 More...
NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
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Chrna4
cholinergic receptor nicotinic alpha 4 subunit
multiple interactions
ISO
Succinylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]
CTD
PMID:14645658
NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
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Chrnb2
cholinergic receptor nicotinic beta 2 subunit
multiple interactions
ISO
Succinylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]
CTD
PMID:14645658
NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
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Mb
myoglobin
increases secretion
ISO
Succinylcholine results in increased secretion of MB protein
CTD
PMID:8217179
NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383
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Abhd11
abhydrolase domain containing 11
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ABHD11 protein
CTD
PMID:18951874
NCBI chr12:21,682,206...21,685,331
Ensembl chr12:21,682,202...21,685,398
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Abl2
ABL proto-oncogene 2, non-receptor tyrosine kinase
decreases expression
ISO
Theophylline results in decreased expression of ABL2 mRNA
CTD
PMID:16083514
NCBI chr13:68,673,702...68,770,846
Ensembl chr13:68,673,722...68,839,742
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Acaa1a
acetyl-CoA acyltransferase 1A
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ACAA1 protein
CTD
PMID:18951874
NCBI chr 8:119,079,401...119,088,626
Ensembl chr 8:119,079,775...119,088,624
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Acadm
acyl-CoA dehydrogenase medium chain
decreases expression
EXP
Theophylline results in decreased expression of ACADM mRNA
CTD
PMID:17522070
NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
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Ace2
angiotensin converting enzyme 2
decreases expression
ISO
Theophylline results in decreased expression of ACE2 mRNA
CTD
PMID:32808185
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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Acot7
acyl-CoA thioesterase 7
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ACOT7 protein
CTD
PMID:18951874
NCBI chr 5:162,686,562...162,779,309
Ensembl chr 5:162,684,645...162,779,309
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Acp5
acid phosphatase 5, tartrate resistant
increases expression
EXP
Theophylline results in increased expression of ACP5 mRNA; Theophylline results in increased expression of ACP5 protein
CTD
PMID:26851681
NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
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Acta2
actin alpha 2, smooth muscle
multiple interactions
ISO
Theophylline inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
CTD
PMID:16430859
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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Actr2
actin related protein 2
decreases expression
ISO
Theophylline results in decreased expression of ACTR2 mRNA
CTD
PMID:16083514
NCBI chr14:94,296,443...94,333,735
Ensembl chr14:94,296,443...94,340,524
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Actr3
actin related protein 3
decreases expression
ISO
Theophylline results in decreased expression of ACTR3 mRNA
CTD
PMID:16083514
NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124
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Adad1
adenosine deaminase domain containing 1
decreases expression
ISO
Theophylline results in decreased expression of ADAD1 mRNA
CTD
PMID:18951874
NCBI chr 2:119,948,809...120,005,920
Ensembl chr 2:119,948,926...120,005,913
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Adamtsl3
ADAMTS-like 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ADAMTSL3 protein
CTD
PMID:18951874
NCBI chr 1:136,288,793...136,596,986
Ensembl chr 1:136,288,793...136,596,986
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Adora1
adenosine A1 receptor
decreases activity decreases expression multiple interactions
EXP
Theophylline results in decreased activity of ADORA1 protein Theophylline results in decreased expression of ADORA1 mRNA Theophylline binds to and results in decreased activity of ADORA1 protein
CTD
PMID:9535120 PMID:12153486 PMID:14992338 PMID:15708489
NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801
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Aff4
ALF transcription elongation factor 4
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of AFF4 protein
CTD
PMID:18951874
NCBI chr10:37,498,825...37,579,751
Ensembl chr10:37,498,825...37,579,751
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Agfg1
ArfGAP with FG repeats 1
increases expression
ISO
Theophylline results in increased expression of AGFG1 mRNA
CTD
PMID:18951874
NCBI chr 9:84,124,845...84,182,615
Ensembl chr 9:84,125,120...84,178,128
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Ahctf1
AT hook containing transcription factor 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of AHCTF1 protein
CTD
PMID:18951874
NCBI chr13:91,481,936...91,536,391
Ensembl chr13:91,481,936...91,536,391
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Akt1s1
AKT1 substrate 1
increases expression
ISO
Theophylline results in increased expression of AKT1S1 mRNA
CTD
PMID:18951874
NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677
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Aldoc
aldolase, fructose-bisphosphate C
decreases expression
ISO
Theophylline results in decreased expression of ALDOC mRNA
CTD
PMID:16083514
NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066
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Alg9
ALG9, alpha-1,2-mannosyltransferase
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ALG9 protein
CTD
PMID:18951874
NCBI chr 8:51,117,057...51,188,790
Ensembl chr 8:51,119,365...51,182,261
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Andpro
androgen regulated protein
increases expression
EXP
Theophylline results in increased expression of CST4 mRNA
CTD
PMID:16651698
NCBI chr 3:136,718,601...136,725,131
Ensembl chr 3:136,718,602...136,724,966
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Ankdd1a
ankyrin repeat and death domain containing 1A
increases expression
ISO
Theophylline results in increased expression of ANKDD1A mRNA
CTD
PMID:18951874
NCBI chr 8:66,017,571...66,043,738
Ensembl chr 8:66,017,773...66,042,651
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Ankrd13c
ankyrin repeat domain 13C
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ANKRD13C protein
CTD
PMID:18951874
NCBI chr 2:247,023,040...247,070,433
Ensembl chr 2:247,022,286...247,070,433
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Ankrd44
ankyrin repeat domain 44
increases expression
ISO
Theophylline results in increased expression of ANKRD44 mRNA
CTD
PMID:18951874
NCBI chr 9:56,126,746...56,427,661
Ensembl chr 9:56,126,747...56,427,508
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Aoc1
amine oxidase, copper containing 1
increases activity decreases expression
EXP ISO
Theophylline results in increased activity of AOC1 protein Theophylline results in decreased expression of AOC1 mRNA
CTD
PMID:2860926 PMID:18951874
NCBI chr 4:77,812,260...77,831,846
Ensembl chr 4:77,812,260...77,831,840
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Apex1
apurinic/apyrimidinic endodeoxyribonuclease 1
decreases expression
EXP
Theophylline results in decreased expression of APEX1 mRNA
CTD
PMID:17522070
NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
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Arf1
ADP-ribosylation factor 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ARF1 protein
CTD
PMID:18951874
NCBI chr10:43,997,983...44,014,461
Ensembl chr10:43,997,986...44,014,434
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Arhgap15
Rho GTPase activating protein 15
increases expression
ISO
Theophylline results in increased expression of ARHGAP15 mRNA
CTD
PMID:18951874
NCBI chr 3:27,989,368...28,592,722
Ensembl chr 3:27,989,633...28,600,265
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Arid2
AT-rich interaction domain 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ARID2 protein
CTD
PMID:18951874
NCBI chr 7:127,447,192...127,565,987
Ensembl chr 7:127,447,278...127,563,512
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Armc8
armadillo repeat containing 8
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ARMC8 protein
CTD
PMID:18951874
NCBI chr 8:100,036,946...100,131,544
Ensembl chr 8:100,036,946...100,131,520
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Arnt
aryl hydrocarbon receptor nuclear translocator
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ARNT protein
CTD
PMID:18951874
NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
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Arsb
arylsulfatase B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ARSB protein
CTD
PMID:18951874
NCBI chr 2:25,002,210...25,162,675
Ensembl chr 2:25,002,346...25,162,671
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Asap1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
increases expression
ISO
Theophylline results in increased expression of ASAP1 mRNA
CTD
PMID:18951874
NCBI chr 7:95,786,130...96,093,111
Ensembl chr 7:95,787,818...96,092,754
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Asl
argininosuccinate lyase
decreases expression
EXP
Theophylline results in decreased expression of ASL mRNA
CTD
PMID:17522070
NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662
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Atg3
autophagy related 3
increases expression
ISO
Theophylline results in increased expression of ATG3 mRNA
CTD
PMID:18951874
NCBI chr11:55,624,914...55,653,249
Ensembl chr11:55,624,917...55,653,224
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Atpaf2
ATP synthase mitochondrial F1 complex assembly factor 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ATPAF2 protein
CTD
PMID:18951874
NCBI chr10:45,205,658...45,221,891
Ensembl chr10:45,197,441...45,221,026
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Atrx
ATRX, chromatin remodeler
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ATRX protein
CTD
PMID:18951874
NCBI chr X:70,850,981...70,997,330
Ensembl chr X:70,850,981...70,997,330
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Aurkb
aurora kinase B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of AURKB protein
CTD
PMID:18951874
NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
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Azi2
5-azacytidine induced 2
multiple interactions decreases expression
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of AZI2 protein Theophylline results in decreased expression of AZI2 mRNA
CTD
PMID:18951874
NCBI chr 8:117,773,248...117,797,844
Ensembl chr 8:117,773,279...117,797,847
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B3galnt2
beta-1,3-N-acetylgalactosaminyltransferase 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of B3GALNT2 protein
CTD
PMID:18951874
NCBI chr17:51,334,921...51,377,469
Ensembl chr17:51,334,921...51,377,469
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B4galt7
beta-1,4-galactosyltransferase 7
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of B4GALT7 protein
CTD
PMID:18951874
NCBI chr17:9,018,514...9,027,591
Ensembl chr17:9,018,935...9,027,573
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Babam2
BRISC and BRCA1 A complex member 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of BABAM2 protein
CTD
PMID:18951874
NCBI chr 6:24,369,021...24,788,416
Ensembl chr 6:24,369,022...24,833,951
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Bag5
BAG cochaperone 5
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of BAG5 protein
CTD
PMID:18951874
NCBI chr 6:130,768,467...130,772,122
Ensembl chr 6:130,768,141...130,772,970
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Bcl2
BCL2, apoptosis regulator
multiple interactions decreases expression
ISO
[Theophylline co-treated with Cisplatin] results in decreased expression of BCL2 protein; [Theophylline co-treated with Gemcitabine] results in decreased expression of BCL2 protein; IL4 protein inhibits the reaction [Theophylline results in decreased expression of BCL2 protein] Theophylline results in decreased expression of BCL2 mRNA; Theophylline results in decreased expression of BCL2 protein
CTD
PMID:8822937 PMID:9312165 PMID:10877050 PMID:10891529 PMID:15313391 PMID:15645133 More...
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl7c
BAF chromatin remodeling complex subunit BCL7C
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of BCL7C protein
CTD
PMID:18951874
NCBI chr 1:182,277,163...182,324,274
Ensembl chr 1:182,260,164...182,324,163
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Bcr
BCR activator of RhoGEF and GTPase
increases expression
ISO
Theophylline results in increased expression of BCR mRNA
CTD
PMID:16083514
NCBI chr20:13,469,325...13,596,942
Ensembl chr20:13,471,668...13,597,016
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Blnk
B-cell linker
increases expression
ISO
Theophylline results in increased expression of BLNK mRNA
CTD
PMID:16083514
NCBI chr 1:239,753,640...239,821,113
Ensembl chr 1:239,753,648...239,821,113
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Bptf
bromodomain PHD finger transcription factor
decreases expression
ISO
Theophylline results in decreased expression of BPTF mRNA
CTD
PMID:18951874
NCBI chr10:91,980,279...92,082,731
Ensembl chr10:91,982,758...92,082,769
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Braf
B-Raf proto-oncogene, serine/threonine kinase
multiple interactions
EXP
[Theophylline results in increased abundance of Cyclic AMP] which results in increased activity of BRAF protein
CTD
PMID:21693435
NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
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Btbd10
BTB domain containing 10
increases expression
ISO
Theophylline results in increased expression of BTBD10 mRNA
CTD
PMID:16083514
NCBI chr 1:167,431,311...167,489,320
Ensembl chr 1:167,431,329...167,489,916
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Btg3
BTG anti-proliferation factor 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of BTG3 protein
CTD
PMID:18951874
NCBI chr11:17,030,156...17,046,069
Ensembl chr11:17,030,160...17,046,170
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C2cd5
C2 calcium-dependent domain containing 5
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of C2CD5 protein
CTD
PMID:18951874
NCBI chr 4:175,969,544...176,055,597
Ensembl chr 4:175,969,545...176,055,558
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C4h3orf20
similar to human chromosome 3 open reading frame 20
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of C3ORF20 protein
CTD
PMID:18951874
NCBI chr 4:124,422,033...124,470,657
Ensembl chr 4:124,432,193...124,469,254
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C5
complement C5
multiple interactions
ISO
Theophylline inhibits the reaction [C5 protein modified form results in increased abundance of Superoxides]; Theophylline promotes the reaction [C5 protein modified form results in increased abundance of Superoxides]
CTD
PMID:10947063
NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
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Calu
calumenin
increases expression
EXP
Theophylline results in increased expression of CALU mRNA
CTD
PMID:17522070
NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593
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Camk2d
calcium/calmodulin-dependent protein kinase II delta
decreases expression
ISO
Theophylline results in decreased expression of CAMK2D mRNA
CTD
PMID:18951874
NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178
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Cand1
cullin-associated and neddylation-dissociated 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of CAND1 protein
CTD
PMID:18951874
NCBI chr 7:54,681,114...54,719,002
Ensembl chr 7:54,680,900...54,718,993
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Caprin1
cell cycle associated protein 1
increases expression
ISO
Theophylline results in increased expression of CAPRIN1 mRNA
CTD
PMID:18951874
NCBI chr 3:90,152,305...90,230,447
Ensembl chr 3:90,153,620...90,230,502
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Capza1
capping actin protein of muscle Z-line subunit alpha 1
decreases expression
ISO
Theophylline results in decreased expression of CAPZA1 mRNA
CTD
PMID:16083514
NCBI chr 2:192,319,696...192,364,755
Ensembl chr 2:192,319,702...192,364,480
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Casp2
caspase 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of CASP2 protein
CTD
PMID:18951874
NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
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Casp3
caspase 3
increases activity
ISO
Theophylline results in increased activity of CASP3 protein
CTD
PMID:14634331
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cat
catalase
multiple interactions
EXP
Theophylline inhibits the reaction [Phenylisopropyladenosine results in increased expression of CAT protein]
CTD
PMID:15792369
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cav1
caveolin 1
increases expression
ISO
Theophylline results in increased expression of CAV1 mRNA
CTD
PMID:16083514
NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
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Ccdc181
coiled-coil domain containing 181
decreases expression
ISO
Theophylline results in decreased expression of CCDC181 mRNA
CTD
PMID:18951874
NCBI chr13:76,624,567...76,638,224
Ensembl chr13:76,624,567...76,638,224
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Ccdc30
coiled-coil domain containing 30
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CCDC30 protein
CTD
PMID:18951874
NCBI chr 5:132,926,767...133,019,635
Ensembl chr 5:132,926,615...133,019,659
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Ccdc82
coiled-coil domain containing 82
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CCDC82 protein
CTD
PMID:18951874
NCBI chr 8:10,227,727...10,265,963
Ensembl chr 8:10,228,430...10,265,963
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Ccdc93
coiled-coil domain containing 93
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CCDC93 protein
CTD
PMID:18951874
NCBI chr13:32,607,618...32,675,993
Ensembl chr13:32,607,587...32,676,023
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Ccl2
C-C motif chemokine ligand 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CCL2 protein
CTD
PMID:18951874
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccnd1
cyclin D1
multiple interactions
ISO EXP
[Theophylline results in increased abundance of Cyclic AMP] which results in increased expression of CCND1 protein [Theophylline results in increased abundance of Cyclic AMP] which results in increased expression of CCND1 protein; sorafenib inhibits the reaction [[Theophylline results in increased abundance of Cyclic AMP] which results in increased expression of CCND1 protein]
CTD
PMID:21693435
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Ccser2
coiled-coil serine-rich protein 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of CCSER2 protein
CTD
PMID:18951874
NCBI chr16:12,613,103...12,725,764
Ensembl chr16:12,613,103...12,725,738
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Cd33
CD33 molecule
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CD33 protein
CTD
PMID:18951874
NCBI chr 1:93,935,418...93,940,452
Ensembl chr 1:93,930,971...93,950,149
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Cd36
CD36 molecule
decreases expression
ISO
Theophylline results in decreased expression of CD36 mRNA
CTD
PMID:16083514
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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Cd4
Cd4 molecule
decreases expression
ISO
Theophylline results in decreased expression of CD4 protein
CTD
PMID:11408767
NCBI chr 4:157,668,878...157,695,366
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Cdk13
cyclin-dependent kinase 13
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of CDK13 protein
CTD
PMID:18951874
NCBI chr17:47,251,145...47,344,675
Ensembl chr17:47,251,163...47,341,721
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
multiple interactions
ISO EXP
[Theophylline results in increased abundance of Cyclic AMP] which results in increased expression of CDKN1B protein [Theophylline results in increased abundance of Cyclic AMP] which results in increased expression of CDKN1B protein; sorafenib inhibits the reaction [[Theophylline results in increased abundance of Cyclic AMP] which results in increased expression of CDKN1B protein]
CTD
PMID:21693435
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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Cdkn1c
cyclin-dependent kinase inhibitor 1C
increases expression
ISO
Theophylline results in increased expression of CDKN1C mRNA
CTD
PMID:16083514
NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048
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Ceacam1
CEA cell adhesion molecule 1
decreases expression
EXP
Theophylline results in decreased expression of CEACAM1 mRNA
CTD
PMID:17522070
NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992
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Cenpu
centromere protein U
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CENPU protein
CTD
PMID:18951874
NCBI chr16:45,715,821...45,739,038
Ensembl chr16:45,714,294...45,738,823
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Cep290
centrosomal protein 290
decreases expression
ISO
Theophylline results in decreased expression of CEP290 mRNA
CTD
PMID:18951874
NCBI chr 7:35,310,071...35,399,388
Ensembl chr 7:35,310,199...35,399,392
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Cep63
centrosomal protein 63
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CEP63 protein
CTD
PMID:18951874
NCBI chr 8:103,162,639...103,214,177
Ensembl chr 8:103,162,700...103,214,177
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Cept1
choline/ethanolamine phosphotransferase 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of CEPT1 protein
CTD
PMID:18951874
NCBI chr 2:193,994,220...194,036,141
Ensembl chr 2:193,993,447...194,035,578
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Cfap97
cilia and flagella associated protein 97
increases expression
ISO
Theophylline results in increased expression of CFAP97 mRNA
CTD
PMID:18951874
NCBI chr16:46,086,104...46,135,194
Ensembl chr16:46,086,111...46,125,933
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Cga
glycoprotein hormones, alpha polypeptide
multiple interactions increases stability increases expression
ISO
[Theophylline co-treated with Butyric Acid] results in increased expression of CGA mRNA; Theophylline inhibits the reaction [Butyric Acid results in decreased stability of CGA mRNA]; Theophylline promotes the reaction [Butyric Acid results in increased expression of CGA protein] Theophylline results in increased stability of CGA mRNA Theophylline results in increased expression of CGA protein
CTD
PMID:1693836 PMID:1693837
NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191
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Clec16a
C-type lectin domain containing 16A
decreases expression
ISO
Theophylline results in decreased expression of CLEC16A mRNA
CTD
PMID:18951874
NCBI chr10:4,927,799...5,123,749
Ensembl chr10:4,928,030...5,123,578
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Clec4f
C-type lectin domain family 4, member F
decreases expression
ISO
Theophylline results in decreased expression of CLEC4F mRNA
CTD
PMID:18951874
NCBI chr 4:116,129,023...116,138,744
Ensembl chr 4:116,129,023...116,138,775
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Clpb
ClpB family mitochondrial disaggregase
multiple interactions increases expression
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CLPB protein Theophylline results in increased expression of CLPB mRNA
CTD
PMID:18951874
NCBI chr 1:156,028,740...156,158,183
Ensembl chr 1:156,028,930...156,168,788
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Clu
clusterin
increases expression
EXP
Theophylline results in increased expression of CLU mRNA
CTD
PMID:17522070
NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
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Col1a1
collagen type I alpha 1 chain
multiple interactions
ISO
Theophylline inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Theophylline promotes the reaction [Dexamethasone inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]
CTD
PMID:16430859
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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Coq4
coenzyme Q4
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of COQ4 protein
CTD
PMID:18951874
NCBI chr 3:13,060,054...13,070,502
Ensembl chr 3:13,060,455...13,068,799
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Cox5b
cytochrome c oxidase subunit 5B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of COX5B protein
CTD
PMID:18951874
NCBI chr 9:38,921,980...38,923,806
Ensembl chr 9:38,921,967...38,925,052
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Cpm
carboxypeptidase M
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CPM protein
CTD
PMID:18951874
NCBI chr 7:53,225,647...53,286,220
Ensembl chr 7:53,225,696...53,286,220
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Cpne1
copine 1
affects binding
ISO
Theophylline binds to CPNE1 protein
CTD
PMID:18951874
NCBI chr 3:144,587,531...144,629,911
Ensembl chr 3:144,588,995...144,598,636
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Creld1
cysteine-rich with EGF-like domains 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CRELD1 protein
CTD
PMID:18951874
NCBI chr 4:146,631,883...146,641,493
Ensembl chr 4:146,631,883...146,641,499
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Crtc3
CREB regulated transcription coactivator 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of CRTC3 protein
CTD
PMID:18951874
NCBI chr 1:134,552,830...134,655,929
Ensembl chr 1:134,554,696...134,655,500
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Csf2
colony stimulating factor 2
multiple interactions decreases expression
ISO
[Theophylline co-treated with Dexamethasone] inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]; Theophylline inhibits the reaction [CSF2 protein results in increased expression of EDN1 mRNA]; Theophylline promotes the reaction [IL1B protein results in increased secretion of CSF2 protein]; trichostatin A inhibits the reaction [[Theophylline co-treated with Dexamethasone] inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]] Theophylline results in decreased expression of CSF2 mRNA
CTD
PMID:10374451 PMID:10596698 PMID:12070353
NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
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Csf3
colony stimulating factor 3
increases expression
ISO
Theophylline results in increased expression of CSF3 protein
CTD
PMID:7540958
NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
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Csnk1e
casein kinase 1, epsilon
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CSNK1E protein
CTD
PMID:18951874
NCBI chr 7:110,983,322...111,006,926
Ensembl chr 7:110,983,318...111,006,794
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Ctps1
CTP synthase 1
decreases expression
ISO
Theophylline results in decreased expression of CTPS1 mRNA
CTD
PMID:16083514
NCBI chr 5:134,125,022...134,154,155
Ensembl chr 5:134,125,025...134,154,180
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Ctrl
chymotrypsin-like
increases expression
ISO
Theophylline results in increased expression of CTRL mRNA
CTD
PMID:18951874
NCBI chr19:33,827,279...33,829,129
Ensembl chr19:33,827,229...33,833,626
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Ctsb
cathepsin B
increases expression
ISO
Theophylline results in increased expression of CTSB mRNA
CTD
PMID:16083514
NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
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Ctsl
cathepsin L
decreases expression
EXP
Theophylline results in decreased expression of CTSL mRNA
CTD
PMID:17522070
NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions increases chemical synthesis affects response to substance affects hydroxylation affects metabolic processing increases metabolic processing decreases activity
ISO EXP
[CYP1A2 protein binds to and results in increased metabolism of Caffeine] which results in increased chemical synthesis of Theophylline; [Ofloxacin co-treated with Clarithromycin] inhibits the reaction [CYP1A2 protein results in increased metabolism of Theophylline]; Fluvoxamine inhibits the reaction [CYP1A2 protein affects the metabolism of Theophylline]; Griseofulvin promotes the reaction [CYP1A2 protein affects the metabolism of Theophylline]; zafirlukast inhibits the reaction [CYP1A2 protein results in increased metabolism of Theophylline] CYP1A2 protein results in increased chemical synthesis of Theophylline CYP1A2 gene SNP affects the susceptibility to Theophylline CYP1A2 promoter SNP affects the hydroxylation of Theophylline CYP1A2 gene SNP affects the metabolism of Theophylline; CYP1A2 protein affects the metabolism of Theophylline andrographolide affects the reaction [CYP1A2 protein results in increased metabolism of Theophylline]; Plant Extracts affects the reaction [CYP1A2 protein results in increased metabolism of Theophylline]; rutecarpine promotes the reaction [CYP1A2 protein affects the metabolism of Theophylline] Theophylline results in decreased activity of CYP1A2 protein
CTD
PMID:1302044 PMID:9029748 PMID:9701106 PMID:11408986 PMID:11465391 PMID:11483122 PMID:12732846 PMID:15692829 PMID:15720787 PMID:15948934 PMID:15970798 PMID:15985363 PMID:16841220 PMID:20096675 PMID:20797314 PMID:31132250 More...
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
decreases expression
EXP
Theophylline results in decreased expression of CYP27A1 protein
CTD
PMID:26851681
NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
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Cyp2d3
cytochrome P450, family 2, subfamily d, polypeptide 3
decreases expression
EXP
Theophylline results in decreased expression of CYP2D3 mRNA
CTD
PMID:17522070
NCBI chr 7:113,917,711...113,922,068
Ensembl chr 7:113,908,947...113,922,084
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
affects metabolic processing increases chemical synthesis affects hydroxylation
EXP ISO
CYP2E1 protein affects the metabolism of Theophylline CYP2E1 protein results in increased chemical synthesis of Theophylline CYP2E1 promoter SNP affects the hydroxylation of Theophylline
CTD
PMID:1302044 PMID:15948934 PMID:15985363 PMID:16841220
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Cyp2r1
cytochrome P450, family 2, subfamily r, polypeptide 1
decreases expression
EXP
Theophylline results in decreased expression of CYP2R1 protein
CTD
PMID:26851681
NCBI chr 1:168,749,302...168,798,079
Ensembl chr 1:168,751,038...168,797,759
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions
ISO
[Ofloxacin co-treated with Clarithromycin] inhibits the reaction [CYP3A4 protein results in increased metabolism of Theophylline]
CTD
PMID:11408986
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cysltr1
cysteinyl leukotriene receptor 1
decreases expression
ISO
Theophylline results in decreased expression of CYSLTR1 mRNA
CTD
PMID:18951874
NCBI chr X:71,661,421...71,690,012
Ensembl chr X:71,663,821...71,690,121
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Dab2
DAB adaptor protein 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of DAB2 protein
CTD
PMID:18951874
NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476
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Dact3
dishevelled-binding antagonist of beta-catenin 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of DACT3 protein
CTD
PMID:18951874
NCBI chr 1:77,546,900...77,558,631
Ensembl chr 1:77,546,900...77,558,630
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Dcbld1
discoidin, CUB and LCCL domain containing 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of DCBLD1 protein
CTD
PMID:18951874
NCBI chr20:31,618,556...31,711,697
Ensembl chr20:31,618,542...31,711,692
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Ddi2
DNA damage inducible 1 homolog 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of DDI2 protein
CTD
PMID:18951874
NCBI chr 5:153,989,591...154,035,342
Ensembl chr 5:153,995,589...154,035,283
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Dhx8
DEAH-box helicase 8
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of DHX8 protein
CTD
PMID:18951874
NCBI chr10:86,667,641...86,704,198
Ensembl chr10:86,667,834...86,705,137
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Dlg1
discs large MAGUK scaffold protein 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of DLG1 protein
CTD
PMID:18951874
NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689
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Dmac2l
distal membrane arm assembly component 2 like
decreases expression
ISO
Theophylline results in decreased expression of DMAC2L mRNA
CTD
PMID:18951874
NCBI chr 6:88,205,580...88,223,934
Ensembl chr 6:88,205,700...88,223,933
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Dnajc15
DnaJ heat shock protein family (Hsp40) member C15
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of DNAJC15 protein
CTD
PMID:18951874
NCBI chr15:53,182,060...53,249,675
Ensembl chr15:53,184,855...53,249,675
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Dnajc4
DnaJ heat shock protein family (Hsp40) member C4
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of DNAJC4 protein
CTD
PMID:18951874
NCBI chr 1:204,178,189...204,182,412
Ensembl chr 1:204,178,191...204,182,387
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Dock4
dedicator of cytokinesis 4
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of DOCK4 protein
CTD
PMID:18951874
NCBI chr 6:57,512,929...57,902,597
Ensembl chr 6:57,512,908...57,901,855
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Dolk
dolichol kinase
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of DOLK protein
CTD
PMID:18951874
NCBI chr 3:13,557,826...13,559,864
Ensembl chr 3:13,557,817...13,559,917
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Drd5
dopamine receptor D5
increases expression
ISO
Theophylline results in increased expression of DRD5 mRNA
CTD
PMID:18951874
NCBI chr14:72,487,950...72,491,050
Ensembl chr14:72,489,347...72,490,774
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Dusp19
dual specificity phosphatase 19
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of DUSP19 protein
CTD
PMID:18951874
NCBI chr 3:65,538,424...65,554,465
Ensembl chr 3:65,538,420...65,553,534
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Ears2
glutamyl-tRNA synthetase 2, mitochondrial
increases expression
ISO
Theophylline results in increased expression of EARS2 mRNA
CTD
PMID:18951874
NCBI chr 1:176,597,986...176,625,848
Ensembl chr 1:176,597,986...176,625,836
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Edn1
endothelin 1
multiple interactions
ISO
Theophylline inhibits the reaction [CSF2 protein results in increased expression of EDN1 mRNA]
CTD
PMID:10374451
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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Egln3
egl-9 family hypoxia-inducible factor 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of EGLN3 protein
CTD
PMID:18951874
NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766
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Eif1
eukaryotic translation initiation factor 1
decreases expression
ISO
Theophylline results in decreased expression of SUI1 mRNA
CTD
PMID:16083514
NCBI chr10:85,246,751...85,248,842
Ensembl chr10:85,246,764...85,427,327
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Eif2s3
eukaryotic translation initiation factor 2 subunit gamma
increases expression
ISO
Theophylline results in increased expression of EIF2S3 mRNA
CTD
PMID:16083514
NCBI chr X:58,916,513...58,939,923
Ensembl chr X:58,917,490...58,940,686
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Eif3a
eukaryotic translation initiation factor 3, subunit A
increases expression
ISO
Theophylline results in increased expression of EIF3A mRNA
CTD
PMID:16083514
NCBI chr 1:259,902,767...259,932,976
Ensembl chr 1:259,902,680...259,932,976
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Eif3b
eukaryotic translation initiation factor 3, subunit B
increases expression
ISO
Theophylline results in increased expression of EIF3B mRNA
CTD
PMID:18951874
NCBI chr12:14,196,403...14,220,865
Ensembl chr12:14,196,403...14,220,886
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Eif3e
eukaryotic translation initiation factor 3 subunit E
decreases expression
ISO
Theophylline results in decreased expression of EIF3E mRNA
CTD
PMID:16083514
NCBI chr 7:74,339,848...74,372,483
Ensembl chr 7:74,339,828...74,373,096
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Eif4b
eukaryotic translation initiation factor 4B
increases expression
ISO
Theophylline results in increased expression of EIF4B mRNA
CTD
PMID:16083514
NCBI chr 7:133,206,637...133,228,436
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Eif5
eukaryotic translation initiation factor 5
decreases expression
ISO
Theophylline results in decreased expression of EIF5 mRNA
CTD
PMID:16083514
NCBI chr 6:130,589,162...130,597,656
Ensembl chr 6:130,589,143...130,597,656
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Elp6
elongator acetyltransferase complex subunit 6
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ELP6 protein
CTD
PMID:18951874
NCBI chr 8:110,280,059...110,295,070
Ensembl chr 8:110,279,979...110,295,067
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Emc3
ER membrane protein complex subunit 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of EMC3 protein
CTD
PMID:18951874
NCBI chr 4:146,663,065...146,678,976
Ensembl chr 4:146,663,067...146,679,029
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Entpd5
ectonucleoside triphosphate diphosphohydrolase 5
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ENTPD5 protein
CTD
PMID:18951874
NCBI chr 6:104,019,095...104,055,311
Ensembl chr 6:104,019,185...104,055,530
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Epg5
ectopic P-granules 5 autophagy tethering factor
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of EPG5 protein
CTD
PMID:18951874
NCBI chr18:71,403,990...71,502,079
Ensembl chr18:71,404,010...71,501,502
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Eps15
epidermal growth factor receptor pathway substrate 15
decreases expression
ISO
Theophylline results in decreased expression of EPS15 mRNA
CTD
PMID:18951874
NCBI chr 5:124,045,865...124,146,221
Ensembl chr 5:124,045,926...124,146,221
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Eps8l1
EPS8-like 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of EPS8L1 protein
CTD
PMID:18951874
NCBI chr 1:69,343,202...69,359,778
Ensembl chr 1:69,344,243...69,363,524
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Ercc5
ERCC excision repair 5, endonuclease
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ERCC5 protein
CTD
PMID:18951874
NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472
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Erf
Ets2 repressor factor
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ERF protein
CTD
PMID:18951874
NCBI chr 1:80,829,935...80,838,388
Ensembl chr 1:80,829,935...80,838,388
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Ergic1
endoplasmic reticulum-golgi intermediate compartment 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ERGIC1 protein
CTD
PMID:18951874
NCBI chr10:16,531,192...16,626,974
Ensembl chr10:16,531,194...16,626,957
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Erlin1
ER lipid raft associated 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ERLIN1 protein
CTD
PMID:18951874
NCBI chr 1:242,921,147...242,956,472
Ensembl chr 1:242,921,152...242,956,394
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Erlin2
ER lipid raft associated 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ERLIN2 protein
CTD
PMID:18951874
NCBI chr16:65,017,654...65,034,184
Ensembl chr16:65,018,532...65,033,671
G
Evi2b
ecotropic viral integration site 2B
decreases expression
ISO
Theophylline results in decreased expression of EVI2B mRNA
CTD
PMID:16083514
NCBI chr10:64,472,693...64,474,311
Ensembl chr10:64,471,505...64,481,560
G
Exosc3
exosome component 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of EXOSC3 protein
CTD
PMID:18951874
NCBI chr 5:59,573,849...59,579,065
Ensembl chr 5:59,573,886...59,579,060
G
Exosc4
exosome component 4
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of EXOSC4 protein
CTD
PMID:18951874
NCBI chr 7:108,047,831...108,050,573
Ensembl chr 7:108,047,831...108,050,573
G
Eya3
EYA transcriptional coactivator and phosphatase 3
increases expression
ISO
Theophylline results in increased expression of EYA3 mRNA
CTD
PMID:18951874
NCBI chr 5:144,806,523...144,934,522
Ensembl chr 5:144,806,577...144,934,518
G
Fabp1
fatty acid binding protein 1
increases expression
EXP
Theophylline results in increased expression of FABP1 mRNA
CTD
PMID:17522070
NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
G
Fads3
fatty acid desaturase 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of FADS3 protein
CTD
PMID:18951874
NCBI chr 1:206,685,667...206,702,538
Ensembl chr 1:206,685,894...206,704,769
G
Fam171b
family with sequence similarity 171, member B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of FAM171B protein
CTD
PMID:18951874
NCBI chr 3:68,930,755...68,986,113
Ensembl chr 3:68,930,822...68,986,127
G
Fam222b
family with sequence similarity 222, member B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of FAM222B protein
CTD
PMID:18951874
NCBI chr10:62,986,571...63,052,350
Ensembl chr10:62,986,571...63,052,350
G
Fbxo8
F-box protein 8
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of FBXO8 protein
CTD
PMID:18951874
NCBI chr16:33,665,305...33,711,215
Ensembl chr16:33,665,306...33,711,272
G
Fchsd2
FCH and double SH3 domains 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of FCHSD2 protein
CTD
PMID:18951874
NCBI chr 1:155,444,471...155,685,350
Ensembl chr 1:155,444,460...155,685,539
G
Fdxr
ferredoxin reductase
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of FDXR protein
CTD
PMID:18951874
NCBI chr10:100,507,863...100,516,649
Ensembl chr10:100,507,865...100,516,658
G
Fga
fibrinogen alpha chain
increases expression
EXP
Theophylline results in increased expression of FGA mRNA
CTD
PMID:17522070
NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528
G
Fgb
fibrinogen beta chain
increases expression
EXP
Theophylline results in increased expression of FGB mRNA
CTD
PMID:17522070
NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979
G
Fgf23
fibroblast growth factor 23
increases expression multiple interactions
EXP
Theophylline results in increased expression of FGF23 protein Calcifediol inhibits the reaction [Theophylline results in increased expression of FGF23 protein]
CTD
PMID:26851681
NCBI chr 4:159,914,267...159,923,821
Ensembl chr 4:159,914,272...159,923,821
G
Fhl3
four and a half LIM domains 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of FHL3 protein
CTD
PMID:18951874
NCBI chr 5:136,953,947...136,961,317
Ensembl chr 5:136,950,411...136,961,317
G
Fibp
FGF1 intracellular binding protein
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of FIBP protein
CTD
PMID:18951874
NCBI chr 1:202,768,065...202,772,405
Ensembl chr 1:202,768,078...202,772,399
G
Fip1l1
factor interacting with PAPOLA and CPSF1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of FIP1L1 protein
CTD
PMID:18951874
NCBI chr14:33,615,210...33,675,742
Ensembl chr14:33,617,720...33,675,708
G
Fitm2
fat storage-inducing transmembrane protein 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of FITM2 protein
CTD
PMID:18951874
NCBI chr 3:152,141,346...152,147,858
Ensembl chr 3:152,141,346...152,147,858
G
Flot2
flotillin 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of FLOT2 protein
CTD
PMID:18951874
NCBI chr10:62,926,047...62,947,759
Ensembl chr10:62,920,665...62,947,756
G
Fnbp4
formin binding protein 4
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of FNBP4 protein
CTD
PMID:18951874
NCBI chr 3:76,733,012...76,763,077
Ensembl chr 3:76,733,027...76,763,079
G
Fntb
farnesyltransferase, CAAX box, subunit beta
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of FNTB protein
CTD
PMID:18951874
NCBI chr 6:95,536,540...95,619,587
Ensembl chr 6:95,470,683...95,619,586
G
Folr1
folate receptor alpha
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of FOLR1 protein
CTD
PMID:18951874
NCBI chr 1:156,219,460...156,238,436
Ensembl chr 1:156,219,460...156,230,667
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions
EXP
Theophylline inhibits the reaction [Haloperidol results in increased expression of FOS mRNA]; Theophylline inhibits the reaction [Reserpine results in increased expression of FOS protein]
CTD
PMID:8577368 PMID:10199625
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
G
Foxf2
forkhead box F2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of FOXF2 protein
CTD
PMID:18951874
NCBI chr17:32,835,730...32,842,547
Ensembl chr17:32,836,777...32,842,176
G
Foxk2
forkhead box K2
increases expression
ISO
Theophylline results in increased expression of FOXK2 mRNA
CTD
PMID:16083514
NCBI chr10:106,542,643...106,592,569
Ensembl chr10:106,542,566...106,592,563
G
Fsd1l
fibronectin type III and SPRY domain containing 1-like
increases expression
ISO
Theophylline results in increased expression of FSD1L mRNA
CTD
PMID:18951874
NCBI chr 5:68,258,877...68,334,931
Ensembl chr 5:68,258,932...68,334,928
G
Gabarapl1
GABA type A receptor associated protein like 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of GABARAPL1 protein
CTD
PMID:18951874
NCBI chr 4:162,980,309...162,989,452
Ensembl chr 4:162,980,249...162,989,450
G
Gabra1
gamma-aminobutyric acid type A receptor subunit alpha 1
multiple interactions
ISO
Theophylline results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]
CTD
PMID:11234751
NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
G
Gabrb2
gamma-aminobutyric acid type A receptor subunit beta 2
multiple interactions
ISO
Theophylline results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]
CTD
PMID:11234751
NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251
G
Gabrg2
gamma-aminobutyric acid type A receptor subunit gamma 2
multiple interactions
ISO
Theophylline results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]
CTD
PMID:11234751
NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346
G
Gabrr2
gamma-aminobutyric acid type A receptor subunit rho 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of GABRR2 protein
CTD
PMID:18951874
NCBI chr 5:47,445,280...47,489,929
Ensembl chr 5:47,452,150...47,489,809
G
Gck
glucokinase
increases expression
EXP
Theophylline results in increased expression of GCK mRNA
CTD
PMID:17522070
NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
G
Gdf15
growth differentiation factor 15
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of GDF15 protein
CTD
PMID:18951874
NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
G
Gfpt1
glutamine fructose-6-phosphate transaminase 1
increases expression
ISO
Theophylline results in increased expression of GFPT1 mRNA
CTD
PMID:16083514
NCBI chr 4:119,496,691...119,546,472
Ensembl chr 4:119,496,714...119,546,471
G
Ggps1
geranylgeranyl diphosphate synthase 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of GGPS1 protein
CTD
PMID:18951874
NCBI chr17:51,263,262...51,282,471
Ensembl chr17:51,263,263...51,276,220
G
Gkap1
G kinase anchoring protein 1
increases expression
ISO
Theophylline results in increased expression of GKAP1 mRNA
CTD
PMID:18951874
NCBI chr17:6,383,963...6,423,684
Ensembl chr17:6,383,963...6,423,679
G
Glrx3
glutaredoxin 3
increases expression
ISO
Theophylline results in increased expression of GLRX3 mRNA
CTD
PMID:18951874
NCBI chr 1:192,241,707...192,272,012
Ensembl chr 1:192,241,701...192,272,010
G
Gls
glutaminase
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of GLS protein
CTD
PMID:18951874
NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900
G
Gnai1
G protein subunit alpha i1
decreases expression increases expression
EXP
Theophylline results in decreased expression of GNAI1 protein Theophylline results in increased expression of GNAI1 mRNA
CTD
PMID:15708489
NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417
G
Gnai2
G protein subunit alpha i2
decreases expression
EXP
Theophylline results in decreased expression of GNAI2 protein
CTD
PMID:15708489
NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
G
Gnaq
G protein subunit alpha q
decreases expression
EXP
Theophylline results in decreased expression of GNAQ protein
CTD
PMID:15998294
NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672
G
Gnas
GNAS complex locus
decreases expression
EXP
Theophylline results in decreased expression of GNAS protein
CTD
PMID:15708489
NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262 Ensembl chr 3:163,071,417...163,127,262
G
Gnb1
G protein subunit beta 1
multiple interactions decreases expression
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of GNB1 protein Theophylline results in decreased expression of GNB1 mRNA
CTD
PMID:16083514 PMID:18951874
NCBI chr 5:166,075,508...166,142,223
Ensembl chr 5:166,075,629...166,142,124
G
Gpatch8
G patch domain containing 8
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of GPATCH8 protein
CTD
PMID:18951874
NCBI chr10:87,432,020...87,512,594
Ensembl chr10:87,433,266...87,512,419
G
Gpm6a
glycoprotein m6a
increases expression
ISO
Theophylline results in increased expression of GPM6A mRNA
CTD
PMID:16083514
NCBI chr16:36,641,282...36,973,377
Ensembl chr16:36,641,284...36,973,475
G
Gpr137c
G protein-coupled receptor 137C
increases expression
ISO
Theophylline results in increased expression of GPR137C mRNA
CTD
PMID:18951874
NCBI chr15:18,425,939...18,492,588
Ensembl chr15:18,426,223...18,490,807
G
Gpx1
glutathione peroxidase 1
decreases expression
EXP
Theophylline results in decreased expression of GPX1 mRNA
CTD
PMID:17522070
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
G
Grk3
G protein-coupled receptor kinase 3
multiple interactions decreases expression
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of GRK3 protein Theophylline results in decreased expression of GRK3 mRNA
CTD
PMID:18951874
NCBI chr12:43,624,778...43,735,375
Ensembl chr12:43,624,897...43,731,262
G
Grm1
glutamate metabotropic receptor 1
decreases expression
EXP
Theophylline results in decreased expression of GRM1 protein
CTD
PMID:15998294
NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170
G
Grm6
glutamate metabotropic receptor 6
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of GRM6 protein
CTD
PMID:18951874
NCBI chr10:35,167,985...35,182,717
Ensembl chr10:35,167,985...35,182,717
G
Gsk3b
glycogen synthase kinase 3 beta
increases phosphorylation
ISO
Theophylline results in increased phosphorylation of GSK3B protein
CTD
PMID:32001318
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
G
Gsr
glutathione-disulfide reductase
multiple interactions
EXP
Theophylline inhibits the reaction [Phenylisopropyladenosine results in increased expression of GSR protein]
CTD
PMID:15792369
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
G
Gstm2
glutathione S-transferase mu 2
decreases expression
ISO
Theophylline results in decreased expression of GSTM2 mRNA
CTD
PMID:16083514
NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
G
Gstm5
glutathione S-transferase, mu 5
decreases expression
EXP
Theophylline results in decreased expression of GSTM3 mRNA
CTD
PMID:17522070
NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553
G
H2ac18
H2A clustered histone 18
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of H2AC18 protein
CTD
PMID:18951874
NCBI chr 2:183,808,398...183,808,992
G
Hadh
hydroxyacyl-CoA dehydrogenase
decreases expression
ISO
Theophylline results in decreased expression of HADH mRNA
CTD
PMID:16083514
NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353
G
Hdac1
histone deacetylase 1
increases activity increases expression
ISO
Theophylline results in increased activity of HDAC1 protein Theophylline results in increased expression of HDAC1 protein
CTD
PMID:12070353 PMID:15337792
NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
G
Hdac2
histone deacetylase 2
increases expression
ISO
Theophylline results in increased expression of HDAC2 protein
CTD
PMID:15337792
NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609
G
Hdac3
histone deacetylase 3
increases activity
ISO
Theophylline results in increased activity of HDAC3 protein
CTD
PMID:12070353
NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856
G
Hdc
histidine decarboxylase
affects response to substance
ISO
HDC protein affects the susceptibility to Theophylline
CTD
PMID:12893847
NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341
G
Helq
helicase, POLQ-like
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of HELQ protein
CTD
PMID:18951874
NCBI chr14:8,818,582...8,862,926
Ensembl chr14:8,818,592...8,862,960
G
Hemk1
HemK methyltransferase family member 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of HEMK1 protein
CTD
PMID:18951874
NCBI chr 8:107,999,658...108,010,732
Ensembl chr 8:107,999,644...108,010,256
G
Hibadh
3-hydroxyisobutyrate dehydrogenase
decreases expression
EXP
Theophylline results in decreased expression of HIBADH mRNA
CTD
PMID:17522070
NCBI chr 4:81,649,180...81,747,244
Ensembl chr 4:81,649,175...81,780,617
G
Hint1
histidine triad nucleotide binding protein 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of HINT1 protein
CTD
PMID:18951874
NCBI chr10:38,989,516...38,993,259
Ensembl chr 4:92,100,973...92,101,568
G
Hist1h2ail1
histone cluster 1 H2a family member I like 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of H3C6 protein
CTD
PMID:18951874
NCBI chr17:41,568,181...41,569,093
Ensembl chr17:41,568,471...41,569,109
G
Hm13
histocompatibility minor 13
affects binding
ISO
Theophylline binds to HM13 protein
CTD
PMID:18951874
NCBI chr 3:141,145,792...141,183,557
Ensembl chr 3:141,145,782...141,184,703
G
Hnrnph3
heterogeneous nuclear ribonucleoprotein H3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of HNRNPH3 protein
CTD
PMID:18951874
NCBI chr20:25,616,400...25,625,814
Ensembl chr20:25,614,733...25,625,750
G
Hps4
HPS4, biogenesis of lysosomal organelles complex 3 subunit 2
decreases expression
ISO
Theophylline results in decreased expression of HPS4 mRNA
CTD
PMID:18951874
NCBI chr12:44,264,037...44,294,791
Ensembl chr12:44,264,037...44,294,632
G
Hsd17b14
hydroxysteroid (17-beta) dehydrogenase 14
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of HSD17B14 protein
CTD
PMID:18951874
NCBI chr 1:96,029,224...96,039,577
Ensembl chr 1:96,029,284...96,039,883
G
Hspa2
heat shock protein family A (Hsp70) member 2
increases expression
ISO
Theophylline results in increased expression of HSPA2 mRNA
CTD
PMID:16083514
NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287
G
Htra2
HtrA serine peptidase 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of HTRA2 protein
CTD
PMID:18951874
NCBI chr 4:115,556,914...115,560,202
Ensembl chr 4:115,556,916...115,560,095
G
Hus1
HUS1 checkpoint clamp component
decreases expression
ISO
Theophylline results in decreased expression of HUS1 mRNA
CTD
PMID:18951874
NCBI chr14:83,688,702...83,703,466
Ensembl chr14:83,688,708...83,703,442
G
Icam4
intercellular adhesion molecule 4, Landsteiner-Wiener blood group
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ICAM4 protein
CTD
PMID:18951874
NCBI chr 8:19,566,075...19,567,171
Ensembl chr 8:19,566,075...19,567,171
G
Ice2
interactor of little elongation complex ELL subunit 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ICE2 protein
CTD
PMID:18951874
NCBI chr 8:70,043,419...70,085,217
Ensembl chr 8:70,043,424...70,084,995
G
Idua
alpha-L-iduronidase
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of IDUA protein
CTD
PMID:18951874
NCBI chr14:1,031,588...1,059,494
Ensembl chr14:1,032,171...1,046,522
G
Ier2
immediate early response 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of IER2 protein
CTD
PMID:18951874
NCBI chr19:23,494,551...23,496,075
Ensembl chr19:23,494,184...23,499,211
G
Ifna1
interferon, alpha 1
decreases metabolic processing
ISO
IFNA1 protein results in decreased metabolism of Theophylline
CTD
PMID:9114909
NCBI chr 5:103,097,356...103,097,925
Ensembl chr 5:103,097,356...103,097,925
G
Ifng
interferon gamma
decreases expression
ISO
Theophylline results in decreased expression of IFNG mRNA
CTD
PMID:10596698
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
G
Ift122
intraflagellar transport 122
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of IFT122 protein
CTD
PMID:18951874
NCBI chr 4:148,905,031...148,975,458
Ensembl chr 4:148,905,046...148,975,458
G
Ift57
intraflagellar transport 57
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of IFT57 protein
CTD
PMID:18951874
NCBI chr11:51,051,520...51,124,909
Ensembl chr11:51,059,611...51,124,812
G
Ift88
intraflagellar transport 88
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of IFT88 protein
CTD
PMID:18951874
NCBI chr15:31,573,325...31,666,068
Ensembl chr15:31,573,376...31,672,147
G
Igfbp5
insulin-like growth factor binding protein 5
decreases expression
ISO
Theophylline results in decreased expression of IGFBP5 mRNA
CTD
PMID:16083514
NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156
G
Ihh
Indian hedgehog signaling molecule
increases expression
ISO
Theophylline results in increased expression of IHH mRNA
CTD
PMID:16083514
NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532
G
Ikbip
IKBKB interacting protein
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of IKBIP protein
CTD
PMID:18951874
NCBI chr 7:25,579,865...25,598,548
Ensembl chr 7:25,579,832...25,605,162
G
Il10
interleukin 10
decreases secretion
ISO
Theophylline results in decreased secretion of IL10 protein
CTD
PMID:11694023
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il12a
interleukin 12A
multiple interactions
ISO
Theophylline results in decreased expression of [IL12A protein binds to IL12B protein]
CTD
PMID:15569413
NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
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Il12b
interleukin 12B
multiple interactions decreases expression
ISO
Theophylline results in decreased expression of [IL12A protein binds to IL12B protein] Theophylline results in decreased expression of IL12B protein
CTD
PMID:15569413
NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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Il13
interleukin 13
decreases expression decreases secretion
ISO
Theophylline results in decreased expression of IL13 mRNA; Theophylline results in decreased expression of IL13 protein Theophylline results in decreased secretion of IL13 protein
CTD
PMID:16083514
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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Il18
interleukin 18
multiple interactions
ISO
Theophylline inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein]]]; Theophylline inhibits the reaction [Tobacco Smoke Pollution inhibits the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein]]]
CTD
PMID:18951874
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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Il1b
interleukin 1 beta
multiple interactions
EXP ISO
Theophylline inhibits the reaction [Indomethacin results in increased expression of IL1B protein] [Theophylline co-treated with Dexamethasone] inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]; Theophylline inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Budesonide inhibits the reaction [IL1B protein results in increased acetylation of H4C16 protein]]]; Theophylline promotes the reaction [Dexamethasone inhibits the reaction [Hydrogen Peroxide promotes the reaction [IL1B protein results in increased secretion of CXCL8 protein]]]; Theophylline promotes the reaction [IL1B protein results in increased secretion of CSF2 protein]; trichostatin A inhibits the reaction [[Theophylline co-treated with Dexamethasone] inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]]
CTD
PMID:12070353 PMID:15337792 PMID:16133968 PMID:18951874
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il2
interleukin 2
increases secretion
ISO
Theophylline results in increased secretion of IL2 protein
CTD
PMID:11694023
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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Il2ra
interleukin 2 receptor subunit alpha
decreases expression
ISO
Theophylline results in decreased expression of IL2RA protein
CTD
PMID:1709825
NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
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Il3
interleukin 3
decreases expression
ISO
Theophylline results in decreased expression of IL3 mRNA
CTD
PMID:10596698
NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
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Il4
interleukin 4
multiple interactions decreases expression decreases secretion
ISO
IL4 protein inhibits the reaction [[Theophylline co-treated with Chlorambucil] results in increased expression of MYC protein]; IL4 protein inhibits the reaction [[Theophylline co-treated with Chlorambucil] results in increased expression of TP53]; IL4 protein inhibits the reaction [Theophylline results in decreased expression of BCL2 protein] Theophylline results in decreased expression of IL4 mRNA Theophylline results in decreased secretion of IL4 protein
CTD
PMID:8822937 PMID:10596698 PMID:11694023
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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Il6
interleukin 6
multiple interactions increases expression
ISO
[Albuterol co-treated with Theophylline] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; [Bucladesine co-treated with Theophylline] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; [Dinoprostone co-treated with Theophylline] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; [Theophylline co-treated with Albuterol] inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Theophylline inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Theophylline inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Theophylline inhibits the reaction [TNF protein results in increased expression of IL6 protein] Theophylline results in increased expression of IL6 mRNA
CTD
PMID:11770011 PMID:16083514 PMID:20388727
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Il6r
interleukin 6 receptor
decreases expression
ISO
Theophylline results in decreased expression of IL6R mRNA
CTD
PMID:18951874
NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
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Il6st
interleukin 6 cytokine family signal transducer
increases expression
ISO
Theophylline results in increased expression of IL6ST mRNA
CTD
PMID:16083514
NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936
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Ilk
integrin-linked kinase
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ILK protein
CTD
PMID:18951874
NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140
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Inip
INTS3 and NABP interacting protein
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of INIP protein
CTD
PMID:18951874
NCBI chr 5:74,648,392...74,662,628
Ensembl chr 5:74,648,392...74,662,628
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Ins1
insulin 1
multiple interactions
EXP
[Theophylline co-treated with INS1 protein] results in decreased abundance of Cyclic AMP; INS1 protein inhibits the reaction [[Theophylline co-treated with Norepinephrine] results in increased abundance of Cyclic AMP]; INS1 protein inhibits the reaction [[Theophylline co-treated with POMC protein] results in increased abundance of Cyclic AMP]
CTD
PMID:4306506
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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Irf7
interferon regulatory factor 7
decreases expression
ISO
Theophylline results in decreased expression of IRF7 mRNA
CTD
PMID:16083514
NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
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Irs1
insulin receptor substrate 1
increases expression
ISO
Theophylline results in increased expression of IRS1 mRNA
CTD
PMID:16083514
NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
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Itfg1
integrin alpha FG-GAP repeat containing 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ITFG1 protein
CTD
PMID:18951874
NCBI chr19:21,210,697...21,331,285
Ensembl chr19:21,210,733...21,331,279
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Itgam
integrin subunit alpha M
multiple interactions
ISO
Isoproterenol promotes the reaction [Theophylline inhibits the reaction [Platelet Activating Factor results in increased expression of ITGAM protein]]; Theophylline inhibits the reaction [Platelet Activating Factor results in increased expression of ITGAM protein]
CTD
PMID:9762784
NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
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Itgb2
integrin subunit beta 2
increases expression
ISO
Theophylline results in increased expression of ITGB2 mRNA
CTD
PMID:16083514
NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
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Itm2b
integral membrane protein 2B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ITM2B protein
CTD
PMID:18951874
NCBI chr15:48,545,998...48,568,904
Ensembl chr15:48,546,001...48,568,917
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Jade1
jade family PHD finger 1
increases expression
ISO
Theophylline results in increased expression of JADE1 mRNA
CTD
PMID:18951874
NCBI chr 2:124,543,233...124,596,361
Ensembl chr 2:124,543,286...124,596,354
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Jak1
Janus kinase 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of JAK1 protein
CTD
PMID:18951874
NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
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Kcnc3
potassium voltage-gated channel subfamily C member 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of KCNC3 protein
CTD
PMID:18951874
NCBI chr 1:95,080,960...95,095,165
Ensembl chr 1:95,080,960...95,095,160
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Kcnmb4
potassium calcium-activated channel subfamily M regulatory beta subunit 4
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of KCNMB4 protein
CTD
PMID:18951874
NCBI chr 7:52,066,145...52,119,098
Ensembl chr 7:52,066,136...52,119,278
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Kdm4b
lysine demethylase 4B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of KDM4B protein
CTD
PMID:18951874
NCBI chr 9:1,158,737...1,237,233
Ensembl chr 9:1,158,752...1,236,543
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Kdm6b
lysine demethylase 6B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of KDM6B protein
CTD
PMID:18951874
NCBI chr10:54,120,716...54,142,212
Ensembl chr10:54,121,848...54,130,794
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Kif1b
kinesin family member 1B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of KIF1B protein
CTD
PMID:18951874
NCBI chr 5:159,607,697...159,742,778
Ensembl chr 5:159,561,271...159,742,778
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Kin
Kin17 DNA and RNA binding protein
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of KIN protein
CTD
PMID:18951874
NCBI chr17:68,413,483...68,431,392
Ensembl chr17:68,413,486...68,423,845
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Klhl7
kelch-like family member 7
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of KLHL7 protein
CTD
PMID:18951874
NCBI chr 4:11,006,366...11,055,399
Ensembl chr 4:11,006,375...11,055,541
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Krt8
keratin 8
increases expression
EXP
Theophylline results in increased expression of KRT8 mRNA
CTD
PMID:17522070
NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728
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Lamc1
laminin subunit gamma 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of LAMC1 protein
CTD
PMID:18951874
NCBI chr13:65,374,372...65,501,492
Ensembl chr13:65,374,372...65,501,492
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Lbp
lipopolysaccharide binding protein
increases expression
EXP
Theophylline results in increased expression of LBP mRNA
CTD
PMID:17522070
NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586
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Letm2
leucine zipper and EF-hand containing transmembrane protein 2
decreases expression
ISO
Theophylline results in decreased expression of LETM2 mRNA
CTD
PMID:18951874
NCBI chr16:66,464,958...66,489,640
Ensembl chr16:66,469,111...66,489,704
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Lgals3
galectin 3
increases expression
EXP
Theophylline results in increased expression of LGALS3 mRNA
CTD
PMID:17522070
NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
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Lhfpl6
LHFPL tetraspan subfamily member 6
multiple interactions decreases expression
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of LHFPL6 protein Theophylline results in decreased expression of LHFPL6 mRNA
CTD
PMID:18951874
NCBI chr 2:137,126,485...137,324,442
Ensembl chr 2:137,126,509...137,324,443
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Limk1
LIM domain kinase 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of LIMK1 protein
CTD
PMID:18951874
NCBI chr12:22,026,697...22,060,605
Ensembl chr12:22,026,672...22,060,606
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Lipc
lipase C, hepatic type
decreases expression
EXP
Theophylline results in decreased expression of LIPC mRNA
CTD
PMID:17522070
NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464
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Lipe
lipase E, hormone sensitive type
multiple interactions affects localization increases activity
ISO EXP
Theophylline inhibits the reaction [Epinephrine results in increased activity of LIPE protein] Theophylline affects the localization of LIPE protein Theophylline results in increased activity of LIPE protein
CTD
PMID:7155675 PMID:11160373
NCBI chr 1:80,965,612...80,984,313
Ensembl chr 1:80,965,627...80,984,310
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Lpl
lipoprotein lipase
increases expression
ISO
Theophylline results in increased expression of LPL mRNA
CTD
PMID:16083514
NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
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Lrrc23
leucine rich repeat containing 23
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of LRRC23 protein
CTD
PMID:18951874
NCBI chr 4:157,581,285...157,592,188
Ensembl chr 4:157,581,291...157,591,860
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Lsm8
LSM8 homolog, U6 small nuclear RNA associated
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of LSM8 protein
CTD
PMID:18951874
NCBI chr 4:47,306,259...47,312,125
Ensembl chr 4:47,306,295...47,314,293
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Lst1
leukocyte specific transcript 1
increases expression
ISO
Theophylline results in increased expression of LST1 mRNA
CTD
PMID:16083514
NCBI chr20:3,634,680...3,639,731
Ensembl chr20:3,634,749...3,637,997
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Ltb
lymphotoxin beta
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of LTB protein
CTD
PMID:18951874
NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381
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Ltc4s
leukotriene C4 synthase
decreases secretion
ISO
Theophylline results in decreased secretion of LTC4S protein
CTD
PMID:16083514
NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651
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Ltf
lactotransferrin
decreases expression
ISO
Theophylline results in decreased expression of LTF protein
CTD
PMID:12016098
NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795
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Lyplal1
lysophospholipase-like 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of LYPLAL1 protein
CTD
PMID:18951874
NCBI chr13:97,626,568...97,657,901
Ensembl chr13:97,626,451...97,657,867
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Mapk1
mitogen activated protein kinase 1
increases phosphorylation
ISO
Theophylline results in increased phosphorylation of MAPK1 protein
CTD
PMID:32001318
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk1ip1l
mitogen-activated protein kinase 1 interacting protein 1-like
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of MAPK1IP1L protein
CTD
PMID:18951874
NCBI chr15:20,545,043...20,571,466
Ensembl chr15:20,545,059...20,569,674
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Mapk3
mitogen activated protein kinase 3
increases phosphorylation
ISO
Theophylline results in increased phosphorylation of MAPK3 protein
CTD
PMID:32001318
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mapk7
mitogen-activated protein kinase 7
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of MAPK7 protein
CTD
PMID:18951874
NCBI chr10:46,170,264...46,176,262
Ensembl chr10:46,170,167...46,176,267
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Mdh1
malate dehydrogenase 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of MDH1 protein
CTD
PMID:18951874
NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925
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Mecom
MDS1 and EVI1 complex locus
increases expression
ISO
Theophylline results in increased expression of MECOM mRNA
CTD
PMID:16083514
NCBI chr 2:112,909,353...113,464,583
Ensembl chr 2:112,909,321...113,464,590
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Med13l
mediator complex subunit 13L
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of MED13L protein
CTD
PMID:18951874
NCBI chr12:37,807,596...38,004,886
Ensembl chr12:37,808,285...38,004,473
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Med16
mediator complex subunit 16
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of MED16 protein
CTD
PMID:18951874
NCBI chr 7:9,798,641...9,811,172
Ensembl chr 7:9,798,668...9,811,172
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Mef2a
myocyte enhancer factor 2a
decreases expression
ISO
Theophylline results in decreased expression of MEF2A mRNA
CTD
PMID:18951874
NCBI chr 1:120,847,874...120,982,488
Ensembl chr 1:120,850,080...120,981,948
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Mettl15
methyltransferase 15, mitochondrial 12S rRNA N4-cytidine
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of METTL15 protein
CTD
PMID:18951874
NCBI chr 3:95,586,855...95,764,392
Ensembl chr 3:95,586,850...95,764,397
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Mfsd10
major facilitator superfamily domain containing 10
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of MFSD10 protein
CTD
PMID:18951874
NCBI chr14:76,103,762...76,107,385
Ensembl chr14:76,103,815...76,107,377
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Mgst2
microsomal glutathione S-transferase 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of MGST2 protein
CTD
PMID:18951874
NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828
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Milr1
mast cell immunoglobulin-like receptor 1
decreases expression
ISO
Theophylline results in decreased expression of MILR1 mRNA
CTD
PMID:18951874
NCBI chr10:91,684,288...91,705,284
Ensembl chr10:91,687,831...91,705,282
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Mitf
melanocyte inducing transcription factor
increases expression
ISO
Theophylline results in increased expression of MITF protein
CTD
PMID:32001318
NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145
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Mmab
metabolism of cobalamin associated B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of MMAB protein
CTD
PMID:18951874
NCBI chr12:42,159,109...42,172,518
Ensembl chr12:42,159,089...42,172,490
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Mon1b
MON1 homolog B, secretory trafficking associated
decreases expression
ISO
Theophylline results in decreased expression of MON1B mRNA
CTD
PMID:18951874
NCBI chr19:41,617,372...41,625,347
Ensembl chr19:41,617,364...41,625,347
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Mosmo
modulator of smoothened
increases expression
ISO
Theophylline results in increased expression of MOSMO mRNA
CTD
PMID:18951874
NCBI chr 1:175,217,680...175,288,521
Ensembl chr 1:175,217,545...175,288,334
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Mphosph6
M phase phosphoprotein 6
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of MPHOSPH6 protein
CTD
PMID:18951874
NCBI chr19:45,860,152...45,870,117
Ensembl chr19:45,860,154...45,870,170
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Mpo
myeloperoxidase
decreases expression multiple interactions
ISO EXP
Theophylline results in decreased expression of MPO protein Theophylline inhibits the reaction [Indomethacin results in increased activity of MPO protein]
CTD
PMID:12016098 PMID:16133968
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Mtg2
mitochondrial ribosome-associated GTPase 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of MTG2 protein
CTD
PMID:18951874
NCBI chr 3:167,165,542...167,181,358
Ensembl chr 3:167,165,982...167,181,358
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Mtif3
mitochondrial translational initiation factor 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of MTIF3 protein
CTD
PMID:18951874
NCBI chr12:8,126,193...8,140,706
Ensembl chr12:8,126,276...8,140,470
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Mto1
mitochondrial tRNA translation optimization 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of MTO1 protein
CTD
PMID:18951874
NCBI chr 8:79,309,681...79,335,231
Ensembl chr 8:79,309,982...79,335,231
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Muc5b
mucin 5B, oligomeric mucus/gel-forming
decreases expression
ISO
Theophylline results in decreased expression of MUC5B mRNA
CTD
PMID:16083514
NCBI chr 1:196,916,861...196,948,830
Ensembl chr 1:196,916,825...196,949,250
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Mug1
murinoglobulin 1
decreases expression
EXP
Theophylline results in decreased expression of MUG1 mRNA
CTD
PMID:17522070
NCBI chr 4:155,076,270...155,130,051
Ensembl chr 4:155,076,312...155,130,051
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Myc
MYC proto-oncogene, bHLH transcription factor
multiple interactions decreases expression affects expression increases expression
ISO EXP
[Theophylline co-treated with Chlorambucil] results in increased expression of MYC protein; IL4 protein inhibits the reaction [[Theophylline co-treated with Chlorambucil] results in increased expression of MYC protein] Theophylline results in decreased expression of MYC mRNA Theophylline affects the expression of MYC mRNA Theophylline results in increased expression of MYC mRNA mutant form; Theophylline results in increased expression of MYC protein
CTD
PMID:8416737 PMID:8822937 PMID:17522070
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Myo19
myosin XIX
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of MYO19 protein
CTD
PMID:18951874
NCBI chr10:69,753,082...69,782,450
Ensembl chr10:69,753,068...69,782,450
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Mzt1
mitotic spindle organizing protein 1
decreases expression
ISO
Theophylline results in decreased expression of MZT1 mRNA
CTD
PMID:18951874
NCBI chr15:75,787,281...75,797,589
Ensembl chr15:75,786,994...75,797,589
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N4bp2l2
NEDD4 binding protein 2-like 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of N4BP2L2 protein
CTD
PMID:18951874
NCBI chr12:137,342...200,292
Ensembl chr12:103,590...197,784
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Nacc2
NACC family member 2
increases expression
ISO
Theophylline results in increased expression of NACC2 mRNA
CTD
PMID:18951874
NCBI chr 3:8,879,952...8,946,660
Ensembl chr 3:8,883,065...8,946,660
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Napepld
N-acyl phosphatidylethanolamine phospholipase D
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of NAPEPLD protein
CTD
PMID:18951874
NCBI chr 4:13,360,532...13,398,815
Ensembl chr 4:13,361,006...13,398,748
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Nbeal1
neurobeachin-like 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of NBEAL1 protein
CTD
PMID:18951874
NCBI chr 9:61,575,154...61,743,896
Ensembl chr 9:61,575,356...61,736,750
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Nck2
NCK adaptor protein 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of NCK2 protein
CTD
PMID:18951874
NCBI chr 9:45,713,979...45,840,330
Ensembl chr 9:45,714,883...45,840,307
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Ndufb2
NADH:ubiquinone oxidoreductase subunit B2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of NDUFB2 protein
CTD
PMID:18951874
NCBI chr 4:68,367,526...68,374,609
Ensembl chr15:46,536,062...46,536,851 Ensembl chr 4:46,536,062...46,536,851
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Nedd4l
NEDD4 like E3 ubiquitin protein ligase
increases expression
ISO
Theophylline results in increased expression of NEDD4L mRNA
CTD
PMID:16083514
NCBI chr18:58,393,759...58,726,709
Ensembl chr18:58,393,509...58,723,137
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Nfkb1
nuclear factor kappa B subunit 1
multiple interactions
ISO
Theophylline inhibits the reaction [TNF protein affects the localization of NFKB1 protein]
CTD
PMID:10344522
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Nfkbia
NFKB inhibitor alpha
affects expression decreases degradation
ISO
Theophylline affects the expression of NFKBIA protein Theophylline results in decreased degradation of NFKBIA protein
CTD
PMID:11770011 PMID:12065913
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Nkapd1
NKAP domain containing 1
increases expression
ISO
Theophylline results in increased expression of NKAPD1 mRNA
CTD
PMID:18951874
NCBI chr 8:50,955,650...50,966,915
Ensembl chr 8:50,955,654...50,966,830
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Nlk
nemo like kinase
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of NLK protein
CTD
PMID:18951874
NCBI chr10:63,467,388...63,590,960
Ensembl chr10:63,438,222...63,589,730
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Nnt
nicotinamide nucleotide transhydrogenase
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of NNT protein
CTD
PMID:18951874
NCBI chr 2:51,411,413...51,505,125
Ensembl chr 2:51,411,413...51,504,823
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Nop10
NOP10 ribonucleoprotein
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of NOLA3 protein
CTD
PMID:18951874
NCBI chr 3:99,066,857...99,067,942
Ensembl chr 3:99,066,857...99,067,942
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Nos2
nitric oxide synthase 2
multiple interactions
EXP
Theophylline inhibits the reaction [Indomethacin results in increased expression of NOS2 protein]
CTD
PMID:16133968
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nqo2
N-ribosyldihydronicotinamide:quinone dehydrogenase 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of NQO2 protein
CTD
PMID:18951874
NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320
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Nrep
neuronal regeneration related protein
decreases expression
ISO
Theophylline results in decreased expression of NREP mRNA
CTD
PMID:18951874
NCBI chr18:25,017,069...25,046,593
Ensembl chr18:25,017,083...25,046,591
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Nrxn3
neurexin 3
increases expression
ISO
Theophylline results in increased expression of NRXN3 mRNA
CTD
PMID:16083514
NCBI chr 6:107,641,760...109,272,849
Ensembl chr 6:107,641,780...109,272,044
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Ns5atp4
NS5A transactivated protein 4
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of C1ORF43 protein
CTD
PMID:18951874
NCBI chr 2:175,494,406...175,507,281
Ensembl chr 2:175,494,304...175,510,663
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Nsd3
nuclear receptor binding SET domain protein 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of NSD3 protein
CTD
PMID:18951874
NCBI chr16:66,354,030...66,466,202
Ensembl chr16:66,358,973...66,465,423
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Nsun4
NOP2/Sun RNA methyltransferase 4
increases expression
ISO
Theophylline results in increased expression of NSUN4 mRNA
CTD
PMID:18951874
NCBI chr 5:129,511,224...129,532,498
Ensembl chr 5:129,512,307...129,532,423 Ensembl chr 5:129,512,307...129,532,423
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Ntaq1
N-terminal glutamine amidase 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of NTAQ1 protein
CTD
PMID:18951874
NCBI chr 7:89,684,318...89,704,484
Ensembl chr 7:89,684,323...89,704,474
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Nts
neurotensin
multiple interactions
EXP
Theophylline inhibits the reaction [Haloperidol results in increased expression of NTS mRNA]
CTD
PMID:10199625
NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423
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Nup50
nucleoporin 50
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of NUP50 protein
CTD
PMID:18951874
NCBI chr 7:116,047,960...116,065,231
Ensembl chr 7:116,048,021...116,066,905
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Nutf2
nuclear transport factor 2
increases expression
ISO
Theophylline results in increased expression of NUTF2 mRNA
CTD
PMID:16083514
NCBI chr19:33,752,319...33,773,595
Ensembl chr19:33,752,291...33,773,591
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Ociad1
OCIA domain containing 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of OCIAD1 protein
CTD
PMID:18951874
NCBI chr14:34,897,851...34,915,291
Ensembl chr14:34,897,847...34,915,286
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Or4n4
olfactory receptor family 4 subfamily N member 4
increases expression
ISO
Theophylline results in increased expression of OR4N4 mRNA
CTD
PMID:18951874
NCBI chr15:23,494,563...23,495,554
Ensembl chr15:23,492,445...23,498,563
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Osbp
oxysterol binding protein
increases expression
ISO
Theophylline results in increased expression of OSBP mRNA
CTD
PMID:16083514
NCBI chr 1:208,888,697...208,918,511
Ensembl chr 1:208,887,895...208,918,506
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Otc
ornithine transcarbamylase
decreases expression
EXP
Theophylline results in decreased expression of OTC mRNA
CTD
PMID:17522070
NCBI chr X:12,453,834...12,529,954
Ensembl chr X:12,453,834...12,566,918
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Otp
orthopedia homeobox
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of OTP protein; [Hydrogen Peroxide co-treated with Theophylline] results in increased expression of OTP protein
CTD
PMID:18951874
NCBI chr 2:26,108,158...26,116,359
Ensembl chr 2:26,108,163...26,116,359
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Pan3
poly(A) specific ribonuclease subunit PAN3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PAN3 protein
CTD
PMID:18951874
NCBI chr12:7,476,707...7,595,384
Ensembl chr12:7,476,697...7,599,204
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Parp1
poly (ADP-ribose) polymerase 1
affects binding multiple interactions
ISO
Theophylline binds to PARP1 protein [Colforsin co-treated with Theophylline] inhibits the reaction [Etoposide results in increased cleavage of PARP1 protein]
CTD
PMID:9454737 PMID:18951874
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Pbrm1
polybromo 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PB1 protein
CTD
PMID:18951874
NCBI chr16:6,213,507...6,312,895
Ensembl chr16:6,213,300...6,311,780
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Pcp4l1
Purkinje cell protein 4-like 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PCP4L1 protein
CTD
PMID:18951874
NCBI chr13:83,588,992...83,612,631
Ensembl chr13:83,588,992...83,609,966
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Pcsk5
proprotein convertase subtilisin/kexin type 5
increases expression
ISO
Theophylline results in increased expression of PCSK5 mRNA
CTD
PMID:16083514
NCBI chr 1:214,837,847...215,267,626
Ensembl chr 1:214,837,927...215,267,600
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Pde3a
phosphodiesterase 3A
increases expression
EXP
Theophylline results in increased expression of PDE3A mRNA
CTD
PMID:16651698
NCBI chr 4:174,172,804...174,443,944
Ensembl chr 4:174,172,868...174,438,274
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Pdss2
decaprenyl diphosphate synthase subunit 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PDSS2 protein
CTD
PMID:18951874
NCBI chr20:46,709,631...46,938,704
Ensembl chr20:46,709,649...46,938,708
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Pea15
proliferation and apoptosis adaptor protein 15
decreases expression
ISO
Theophylline results in decreased expression of PEA15 mRNA
CTD
PMID:16083514
NCBI chr13:84,657,815...84,667,437
Ensembl chr13:84,654,870...84,667,499
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Pex7
peroxisomal biogenesis factor 7
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of PEX7 protein
CTD
PMID:18951874
NCBI chr 1:14,582,698...14,646,686
Ensembl chr 1:14,582,699...14,646,748
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Pias1
protein inhibitor of activated STAT, 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PIAS1 protein
CTD
PMID:18951874
NCBI chr 8:63,338,150...63,451,670
Ensembl chr 8:63,338,150...63,438,905
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Pias2
protein inhibitor of activated STAT, 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PIAS2 protein
CTD
PMID:18951874
NCBI chr18:70,608,034...70,714,295
Ensembl chr18:70,607,665...70,710,033
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Picalm
phosphatidylinositol binding clathrin assembly protein
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PICALM protein
CTD
PMID:18951874
NCBI chr 1:144,056,415...144,138,045
Ensembl chr 1:144,056,721...144,137,557
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Pigc
phosphatidylinositol glycan anchor biosynthesis, class C
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PIGC protein
CTD
PMID:18951874
NCBI chr13:74,343,619...74,346,148
Ensembl chr13:74,296,854...74,346,211
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Pipox
pipecolic acid and sarcosine oxidase
decreases expression
ISO
Theophylline results in decreased expression of PIPOX mRNA
CTD
PMID:18951874
NCBI chr10:62,769,874...62,783,484
Ensembl chr10:62,769,900...62,782,370
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Pitpnb
phosphatidylinositol transfer protein, beta
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PITPNB protein
CTD
PMID:18951874
NCBI chr12:45,249,308...45,298,388
Ensembl chr12:45,249,333...45,298,314
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Pkhd1
PKHD1 ciliary IPT domain containing fibrocystin/polyductin
decreases expression
ISO
Theophylline results in decreased expression of PKHD1 mRNA
CTD
PMID:18951874
NCBI chr 9:22,547,396...23,037,443
Ensembl chr 9:22,549,513...23,037,381
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Pklr
pyruvate kinase L/R
decreases expression
EXP
Theophylline results in decreased expression of PKLR mRNA
CTD
PMID:17522070
NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
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Plcb1
phospholipase C beta 1
multiple interactions decreases expression
EXP
Theophylline inhibits the reaction [3,4-dihydroxyphenylglycol results in increased activity of PLCB1 protein]; Theophylline inhibits the reaction [[3,4-dihydroxyphenylglycol co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] results in increased activity of PLCB1 protein]; Theophylline inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of PLCB1 protein] Theophylline results in decreased expression of PLCB1 protein
CTD
PMID:15998294
NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869
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Pld3
phospholipase D family, member 3
increases expression
ISO
Theophylline results in increased expression of PLD3 mRNA
CTD
PMID:16083514
NCBI chr 1:82,821,863...82,844,280
Ensembl chr 1:82,821,875...82,844,072
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Plekha1
pleckstrin homology domain containing A1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of PLEKHA1 protein
CTD
PMID:18951874
NCBI chr 1:185,427,982...185,479,157
Ensembl chr 1:185,428,048...185,479,156
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Plrg1
pleiotropic regulator 1
increases expression
ISO
Theophylline results in increased expression of PLRG1 mRNA
CTD
PMID:18951874
NCBI chr 2:168,408,139...168,424,470
Ensembl chr 2:168,408,124...168,424,522
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Polr1b
RNA polymerase I subunit B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of POLR1B protein
CTD
PMID:18951874
NCBI chr 3:116,333,910...116,358,385
Ensembl chr 3:116,333,889...116,358,379
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Polr2f
RNA polymerase II, I and III subunit F
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of POLR2F protein
CTD
PMID:18951874
NCBI chr 7:110,712,528...110,724,234
Ensembl chr 7:110,712,572...110,724,234
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Polr3h
RNA polymerase III subunit H
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of POLR3H protein
CTD
PMID:18951874
NCBI chr 7:113,429,434...113,439,743
Ensembl chr 7:113,429,451...113,439,778
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Polr3k
RNA polymerase III subunit K
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of POLR3K protein
CTD
PMID:18951874
NCBI chr 3:168,982,846...168,987,043
Ensembl chr 3:168,982,812...168,987,040
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Pomc
proopiomelanocortin
multiple interactions
EXP
[Theophylline co-treated with POMC protein] results in increased abundance of Cyclic AMP; INS1 protein inhibits the reaction [[Theophylline co-treated with POMC protein] results in increased abundance of Cyclic AMP]
CTD
PMID:4306506
NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
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Pon1
paraoxonase 1
decreases activity
ISO
Theophylline results in decreased activity of PON1 protein
CTD
PMID:31581362
NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
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Ppara
peroxisome proliferator activated receptor alpha
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of PPARA protein
CTD
PMID:18951874
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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Pparg
peroxisome proliferator-activated receptor gamma
increases expression
ISO
Theophylline results in increased expression of PPARG mRNA; Theophylline results in increased expression of PPARG protein
CTD
PMID:16569937
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Ppp2ca
protein phosphatase 2 catalytic subunit alpha
decreases expression
ISO
Theophylline results in decreased expression of PPP2CA mRNA
CTD
PMID:16083514
NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862
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Ppp3cb
protein phosphatase 3 catalytic subunit beta
decreases expression
ISO
Theophylline results in decreased expression of PPP3CB mRNA
CTD
PMID:16083514
NCBI chr15:3,759,950...3,804,976
Ensembl chr15:3,760,030...3,804,981
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Ppp4r3b
protein phosphatase 4, regulatory subunit 3B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of PPP4R3B protein
CTD
PMID:18951874
NCBI chr14:102,917,043...102,965,210
Ensembl chr14:102,917,443...103,068,192
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Prim2
DNA primase subunit 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PRIM2 protein
CTD
PMID:18951874
NCBI chr 9:35,692,376...35,904,521
Ensembl chr 9:35,692,376...35,903,030
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Prkaa1
protein kinase AMP-activated catalytic subunit alpha 1
decreases expression
ISO
Theophylline results in decreased expression of PRKAA1 mRNA
CTD
PMID:18951874
NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
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Prkaca
protein kinase cAMP-activated catalytic subunit alpha
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of PRKACA protein
CTD
PMID:18951874
NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430
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Prkca
protein kinase C, alpha
decreases expression
ISO
Theophylline results in decreased expression of PRKCA mRNA
CTD
PMID:16083514
NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
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Prkra
protein activator of interferon induced protein kinase EIF2AK2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PRKRA protein
CTD
PMID:18951874
NCBI chr 3:61,575,447...61,594,393
Ensembl chr 3:61,575,447...61,594,347
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Prlr
prolactin receptor
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of PRLR protein
CTD
PMID:18951874
NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718
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Proser3
proline and serine rich 3
increases expression
ISO
Theophylline results in increased expression of PROSER3 mRNA
CTD
PMID:18951874
NCBI chr 1:85,793,363...85,806,682
Ensembl chr 1:85,793,358...85,805,909
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Prpf38b
pre-mRNA processing factor 38B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PRPF38B protein
CTD
PMID:18951874
NCBI chr 2:196,553,224...196,562,271
Ensembl chr 2:196,553,225...196,562,250
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Psmb1
proteasome 20S subunit beta 1
affects expression
EXP
Theophylline affects the expression of PSMB1 mRNA
CTD
PMID:16988215
NCBI chr 1:56,442,432...56,463,544
Ensembl chr 1:56,420,618...56,463,560
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Psmb10
proteasome 20S subunit beta 10
affects expression
EXP
Theophylline affects the expression of PSMB10 mRNA
CTD
PMID:16988215
NCBI chr19:33,830,958...33,833,442
Ensembl chr19:33,827,229...33,833,626
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Psmb2
proteasome 20S subunit beta 2
affects expression
EXP
Theophylline affects the expression of PSMB2 mRNA
CTD
PMID:16988215
NCBI chr 5:138,970,564...139,002,715
Ensembl chr 5:138,970,533...139,021,137
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Psmb5
proteasome 20S subunit beta 5
affects expression
EXP
Theophylline affects the expression of PSMB5 mRNA
CTD
PMID:16988215
NCBI chr15:28,072,772...28,077,367
Ensembl chr15:28,072,781...28,077,440
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Psmb8
proteasome 20S subunit beta 8
affects expression
EXP
Theophylline affects the expression of PSMB8 mRNA
CTD
PMID:16988215
NCBI chr20:4,652,159...4,655,122
Ensembl chr20:4,652,159...4,655,283
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Psmb9
proteasome 20S subunit beta 9
affects expression
EXP
Theophylline affects the expression of PSMB9 mRNA
CTD
PMID:16988215
NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512
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Pth
parathyroid hormone
multiple interactions increases expression
EXP
Calcifediol inhibits the reaction [Theophylline results in increased expression of PTH protein]
CTD
PMID:26851681
NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530
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Ptma
prothymosin alpha
decreases expression
EXP
Theophylline results in decreased expression of PTMA mRNA
CTD
PMID:17522070
NCBI chr 9:87,176,251...87,180,333
Ensembl chr 9:87,176,230...87,180,333
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Ptp4a1
protein tyrosine phosphatase 4A1
decreases expression
ISO
Theophylline results in decreased expression of PTP4A1 mRNA
CTD
PMID:16083514
NCBI chr 9:33,214,201...33,245,046
Ensembl chr 9:33,214,208...33,221,964
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Ptpn2
protein tyrosine phosphatase, non-receptor type 2
increases expression
ISO
Theophylline results in increased expression of PTPN2 mRNA
CTD
PMID:18951874
NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627
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Ptpre
protein tyrosine phosphatase, receptor type, E
increases expression
ISO
Theophylline results in increased expression of PTPRE mRNA
CTD
PMID:18951874
NCBI chr 1:190,344,331...190,494,815
Ensembl chr 1:190,344,401...190,489,534
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Pycr2
pyrroline-5-carboxylate reductase 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of PYCR2 protein
CTD
PMID:18951874
NCBI chr13:92,626,462...92,630,256
Ensembl chr13:92,626,471...92,634,184
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Rab11b
RAB11B, member RAS oncogene family
increases expression
ISO
Theophylline results in increased expression of RAB11B mRNA
CTD
PMID:18951874
NCBI chr 7:14,521,448...14,534,589
Ensembl chr 7:14,521,368...14,534,593
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Rab21
RAB21, member RAS oncogene family
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of RAB21 protein
CTD
PMID:18951874
NCBI chr 7:50,904,050...50,928,890
Ensembl chr 7:50,904,057...50,928,839
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Rad9a
RAD9 checkpoint clamp component A
decreases expression
ISO
Theophylline results in decreased expression of RAD9A mRNA
CTD
PMID:16083514
NCBI chr 1:201,488,511...201,553,582
Ensembl chr 1:201,487,136...201,553,608
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Rangrf
RAN guanine nucleotide release factor
increases expression
ISO
Theophylline results in increased expression of RANGRF mRNA
CTD
PMID:18951874
NCBI chr10:53,677,467...53,678,880
Ensembl chr10:53,677,467...53,678,840
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Rasal2
RAS protein activator like 2
decreases expression
ISO
Theophylline results in decreased expression of RASAL2 mRNA
CTD
PMID:18951874
NCBI chr13:69,279,882...69,569,161
Ensembl chr13:69,258,622...69,569,940
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Rb1
RB transcriptional corepressor 1
multiple interactions
ISO
[Colforsin co-treated with Theophylline] inhibits the reaction [Etoposide results in decreased phosphorylation of RB1 protein]; [Hydrogen Peroxide co-treated with Theophylline] results in increased expression of RB1 protein
CTD
PMID:9454737 PMID:18951874
NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
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Rbm8a
RNA binding motif protein 8A
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of RBM8A protein
CTD
PMID:18951874
NCBI chr 2:184,165,189...184,167,959
Ensembl chr 2:184,165,193...184,167,959
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Rc3h1
ring finger and CCCH-type domains 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of RC3H1 protein
CTD
PMID:18951874
NCBI chr13:73,174,075...73,245,762
Ensembl chr13:73,173,946...73,238,839
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Rcan1
regulator of calcineurin 1
increases expression
ISO
Theophylline results in increased expression of RCAN1 mRNA
CTD
PMID:16083514
NCBI chr11:31,622,208...31,702,150
Ensembl chr11:31,622,210...31,702,045
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Rcc1l
RCC1 like
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of RCC1L protein
CTD
PMID:18951874
NCBI chr12:22,543,125...22,574,042
Ensembl chr12:22,543,734...22,574,036
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Rdh10
retinol dehydrogenase 10
increases expression
ISO
Theophylline results in increased expression of RDH10 mRNA
CTD
PMID:18951874
NCBI chr 5:3,186,671...3,215,572
Ensembl chr 5:3,188,445...3,215,572
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Reck
reversion-inducing-cysteine-rich protein with kazal motifs
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of RECK protein
CTD
PMID:18951874
NCBI chr 5:58,102,961...58,169,516
Ensembl chr 5:58,102,981...58,169,502
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions affects localization
ISO
Theophylline inhibits the reaction [TNF protein results in increased expression of RELA protein] Theophylline affects the localization of RELA protein
CTD
PMID:11770011
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Ren
renin
affects expression
ISO
Theophylline affects the expression of REN protein
CTD
PMID:7743391
NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
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Rfk
riboflavin kinase
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of RFK protein
CTD
PMID:18951874
NCBI chr 1:214,799,880...214,807,440
Ensembl chr 1:214,799,825...214,807,438 Ensembl chr X:214,799,825...214,807,438
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Rftn1
raftlin lipid raft linker 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of RFTN1 protein
CTD
PMID:18951874
NCBI chr 9:10,804,611...11,002,084
Ensembl chr 9:10,804,611...11,002,084
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Rfx7
regulatory factor X, 7
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of RFX7 protein
CTD
PMID:18951874
NCBI chr 8:73,254,051...73,339,209
Ensembl chr 8:73,254,051...73,339,209
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Rgs16
regulator of G-protein signaling 16
increases expression
ISO
Theophylline results in increased expression of RGS16 mRNA
CTD
PMID:16083514
NCBI chr13:65,887,668...65,892,862
Ensembl chr13:65,887,530...65,892,857
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Rhno1
RAD9-HUS1-RAD1 interacting nuclear orphan 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of RHNO1 protein
CTD
PMID:18951874
NCBI chr 4:161,634,047...161,639,437
Ensembl chr 4:161,634,048...161,639,371
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Rhot2
ras homolog family member T2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of RHOT2 protein
CTD
PMID:18951874
NCBI chr10:14,858,954...14,864,751
Ensembl chr10:14,858,956...14,864,751
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Ric3
RIC3 acetylcholine receptor chaperone
affects binding
ISO
Theophylline binds to RIC3 protein
CTD
PMID:18951874
NCBI chr 1:163,030,621...163,086,583
Ensembl chr 1:163,032,158...163,086,519
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Riok3
RIO kinase 3
decreases expression
ISO
Theophylline results in decreased expression of RIOK3 mRNA
CTD
PMID:16083514
NCBI chr18:3,327,776...3,353,350
Ensembl chr18:3,327,776...3,353,343
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Ripk3
receptor-interacting serine-threonine kinase 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of RIPK3 protein
CTD
PMID:18951874
NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
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Rmnd5a
required for meiotic nuclear division 5 homolog A
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of RMND5A protein
CTD
PMID:18951874
NCBI chr 4:103,375,846...103,432,890
Ensembl chr 4:103,379,908...103,433,051
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Rnaset2
ribonuclease T2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of RNASET2 protein
CTD
PMID:18951874
NCBI chr 1:52,576,344...52,603,151
Ensembl chr 1:52,585,929...52,603,147
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Rps15
ribosomal protein S15
decreases expression
ISO
Theophylline results in decreased expression of RPS15 mRNA
CTD
PMID:18951874
NCBI chr 7:9,416,003...9,417,442
Ensembl chr 7:9,416,004...9,417,450
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Sbspon
somatomedin B and thrombospondin, type 1 domain containing
decreases expression
ISO
Theophylline results in decreased expression of SBSPON mRNA
CTD
PMID:18951874
NCBI chr 5:3,402,763...3,433,338
Ensembl chr 5:3,402,648...3,435,420
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Sds
serine dehydratase
increases expression
ISO
Theophylline results in increased expression of SDS mRNA
CTD
PMID:16083514
NCBI chr12:36,083,226...36,090,540
Ensembl chr12:36,083,229...36,088,203
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Secisbp2
SECIS binding protein 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SECISBP2 protein
CTD
PMID:18951874
NCBI chr17:13,538,513...13,569,573
Ensembl chr17:13,538,513...13,569,523
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Sell
selectin L
multiple interactions
ISO
Isoproterenol promotes the reaction [Theophylline inhibits the reaction [Platelet Activating Factor results in increased secretion of SELL protein]]; Theophylline inhibits the reaction [Platelet Activating Factor results in increased secretion of SELL protein]
CTD
PMID:9762784
NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
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Serpina1
serpin family A member 1
affects response to substance
ISO
SERPINA1 gene affects the susceptibility to Theophylline
CTD
PMID:17943569
NCBI chr 6:122,866,314...122,888,339
Ensembl chr 6:122,866,312...122,888,339
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Setd2
SET domain containing 2, histone lysine methyltransferase
decreases expression
ISO
Theophylline results in decreased expression of SETD2 mRNA
CTD
PMID:18951874
NCBI chr 8:110,511,808...110,597,475
Ensembl chr 8:110,511,772...110,597,489
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Sftpb
surfactant protein B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SFTPB protein
CTD
PMID:18951874
NCBI chr 4:104,359,303...104,368,439
Ensembl chr 4:104,359,396...104,368,436
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Sh2d2a
SH2 domain containing 2A
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of SH2D2A protein
CTD
PMID:18951874
NCBI chr 2:173,312,253...173,318,810
Ensembl chr 2:173,312,253...173,318,810
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Sh3rf1
SH3 domain containing ring finger 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SH3RF1 protein
CTD
PMID:18951874
NCBI chr16:28,735,522...28,901,261
Ensembl chr16:28,735,440...28,901,644
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Shprh
SNF2 histone linker PHD RING helicase
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SHPRH protein
CTD
PMID:18951874
NCBI chr 1:5,528,827...5,602,537
Ensembl chr 1:5,528,888...5,602,527
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Sike1
suppressor of IKBKE 1
increases expression
ISO
Theophylline results in increased expression of SIKE1 mRNA
CTD
PMID:18951874
NCBI chr 2:190,518,002...190,525,833
Ensembl chr 2:190,518,002...190,525,832
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Sirt2
sirtuin 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of SIRT2 protein
CTD
PMID:18951874
NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975
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Skic3
SKI3 subunit of superkiller complex
decreases expression
ISO
Theophylline results in decreased expression of SKIC3 mRNA
CTD
PMID:18951874
NCBI chr 2:5,631,544...5,783,643
Ensembl chr 2:5,631,635...5,751,626
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Slc12a8
solute carrier family 12, member 8
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SLC12A8 protein
CTD
PMID:18951874
NCBI chr11:67,116,876...67,266,548
Ensembl chr11:67,116,877...67,266,834
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Slc12a9
solute carrier family 12, member 9
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of SLC12A9 protein
CTD
PMID:18951874
NCBI chr12:19,368,990...19,385,881
Ensembl chr12:19,369,004...19,385,877
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Slc16a1
solute carrier family 16 member 1
multiple interactions
ISO
Theophylline inhibits the reaction [SLC16A1 protein results in increased uptake of Butyrates]
CTD
PMID:19023563
NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
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Slc25a24
solute carrier family 25 member 24
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SLC25A24 protein
CTD
PMID:18951874
NCBI chr 2:196,761,076...196,799,236
Ensembl chr 2:196,761,274...196,799,231
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Slc39a9
solute carrier family 39, member 9
increases expression
ISO
Theophylline results in increased expression of SLC39A9 mRNA
CTD
PMID:18951874
NCBI chr 6:100,291,537...100,330,419
Ensembl chr 6:100,291,573...100,330,408
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Slc5a5
solute carrier family 5 member 5
increases expression
ISO
Theophylline results in increased expression of SLC5A5 protein
CTD
PMID:19409042
NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697
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Slco1b2
solute carrier organic anion transporter family member 1B2
increases expression
EXP
Theophylline results in increased expression of SLCO1B2 mRNA
CTD
PMID:17522070
NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
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Slmap
sarcolemma associated protein
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SLMAP protein
CTD
PMID:18951874
NCBI chr16:1,667,205...1,785,200
Ensembl chr16:1,667,208...1,785,149
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Smad2
SMAD family member 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SMAD2 protein
CTD
PMID:18951874
NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
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Smad5
SMAD family member 5
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SMAD5 protein
CTD
PMID:18951874
NCBI chr17:7,862,332...7,891,678
Ensembl chr17:7,864,720...7,891,634
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Smim7
small integral membrane protein 7
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of SMIM7 protein
CTD
PMID:18951874
NCBI chr16:17,274,417...17,278,336
Ensembl chr16:17,273,258...17,278,336
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Smu1
SMU1, DNA replication regulator and spliceosomal factor
increases expression
ISO
Theophylline results in increased expression of SMU1 mRNA
CTD
PMID:18951874
NCBI chr 5:55,856,691...55,875,262
Ensembl chr 5:55,856,246...55,875,300
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Snap23
synaptosome associated protein 23
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SNAP23 protein
CTD
PMID:18951874
NCBI chr 3:107,514,088...107,546,177
Ensembl chr 3:107,514,131...107,544,320
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Snx13
sorting nexin 13
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SNX13 protein
CTD
PMID:18951874
NCBI chr 6:51,758,258...51,862,260
Ensembl chr 6:51,753,036...51,860,224
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Spats2l
spermatogenesis associated, serine-rich 2-like
decreases expression
ISO
Theophylline results in decreased expression of SPATS2L mRNA
CTD
PMID:18951874
NCBI chr 9:59,319,949...59,493,864
Ensembl chr 9:59,320,276...59,493,967
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Spin2b
spindlin family member 2B
decreases expression
EXP
Theophylline results in decreased expression of SPIN2B mRNA
CTD
PMID:17522070
NCBI chr X:17,190,573...17,192,351
Ensembl chr X:17,180,474...17,192,351
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Srebf1
sterol regulatory element binding transcription factor 1
decreases expression
EXP
Theophylline results in decreased expression of SREBF1 mRNA
CTD
PMID:17522070
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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Srr
serine racemase
decreases expression
ISO
Theophylline results in decreased expression of SRR mRNA
CTD
PMID:18951874
NCBI chr10:59,769,563...59,786,688
Ensembl chr10:59,769,571...59,787,011
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Srsf3
serine and arginine rich splicing factor 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SRSF3 protein
CTD
PMID:18951874
NCBI chr20:7,091,928...7,101,860
Ensembl chr20:7,091,910...7,101,078
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Ssr1
signal sequence receptor subunit 1
decreases expression
ISO
Theophylline results in decreased expression of SSR1 mRNA
CTD
PMID:16083514
NCBI chr17:26,833,720...26,861,821
Ensembl chr17:26,833,741...26,861,821
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Ssr3
signal sequence receptor subunit 3
increases expression
ISO
Theophylline results in increased expression of SSR3 mRNA
CTD
PMID:18951874
NCBI chr 2:149,605,005...149,625,069
Ensembl chr 2:149,605,005...149,625,132
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Sst
somatostatin
increases secretion
ISO
Theophylline results in increased secretion of SST protein
CTD
PMID:16601281
NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173
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St3gal3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ST3GAL3 protein
CTD
PMID:18951874
NCBI chr 5:131,470,348...131,670,794
Ensembl chr 5:131,470,348...131,670,810
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Stam2
signal transducing adaptor molecule 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of STAM2 protein
CTD
PMID:18951874
NCBI chr 3:37,186,145...37,234,810
Ensembl chr 3:37,186,145...37,234,812
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Stat3
signal transducer and activator of transcription 3
increases expression
ISO
Theophylline results in increased expression of STAT3 mRNA
CTD
PMID:16083514
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Stk24
serine/threonine kinase 24
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of STK24 protein
CTD
PMID:18951874
NCBI chr15:98,363,707...98,458,940
Ensembl chr15:98,365,791...98,460,553
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Stk35
serine/threonine kinase 35
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of STK35 protein
CTD
PMID:18951874
NCBI chr 3:117,016,819...117,049,131
Ensembl chr 3:117,016,950...117,048,066
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Supt6h
SPT6 homolog, histone chaperone and transcription elongation factor
decreases expression
ISO
Theophylline results in decreased expression of SUPT6H mRNA
CTD
PMID:16083514
NCBI chr10:63,103,920...63,140,780
Ensembl chr10:63,103,921...63,140,780
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Tac1
tachykinin, precursor 1
multiple interactions
ISO
Theophylline inhibits the reaction [TAC1 protein results in increased secretion of Histamine]
CTD
PMID:1707400
NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
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Taf1a
TATA-box binding protein associated factor, RNA polymerase I subunit A
increases expression
ISO
Theophylline results in increased expression of TAF1A mRNA
CTD
PMID:18951874
NCBI chr13:95,012,160...95,048,131
Ensembl chr13:95,029,225...95,048,087
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Taf7
TATA-box binding protein associated factor 7
decreases expression
ISO
Theophylline results in decreased expression of TAF7 mRNA
CTD
PMID:16083514
NCBI chr18:29,459,937...29,462,086
Ensembl chr18:29,452,943...29,462,134
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Tars2
threonyl-tRNA synthetase 2, mitochondrial
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of TARS2 protein
CTD
PMID:18951874
NCBI chr 2:183,293,095...183,310,210
Ensembl chr 2:183,293,097...183,310,184
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Tas2r116
taste receptor, type 2, member 116
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TAS2R14 protein
CTD
PMID:18951874
NCBI chr 4:166,266,984...166,267,958
Ensembl chr 4:166,266,984...166,267,958
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Tbca
tubulin folding cofactor A
increases expression
ISO
Theophylline results in increased expression of TBCA mRNA
CTD
PMID:18951874
NCBI chr 2:26,011,714...26,065,909
Ensembl chr 2:26,011,795...26,065,907
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Tbxas1
thromboxane A synthase 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TBXAS1 protein
CTD
PMID:18951874
NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096
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Tcf3
transcription factor 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of TCF3 protein
CTD
PMID:18951874
NCBI chr 7:9,280,571...9,302,315
Ensembl chr 7:9,280,571...9,302,314
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Tcn2
transcobalamin 2
increases expression
ISO
Theophylline results in increased expression of TCN2 mRNA
CTD
PMID:16083514
NCBI chr14:78,813,343...78,828,549
Ensembl chr14:78,813,343...78,828,489
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Tefm
transcription elongation factor, mitochondrial
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TEFM protein
CTD
PMID:18951874
NCBI chr10:65,119,657...65,124,233
Ensembl chr10:65,119,659...65,124,486
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Tesk1
testis associated actin remodelling kinase 1
increases expression
ISO
Theophylline results in increased expression of TESK1 mRNA
CTD
PMID:16083514
NCBI chr 5:57,691,922...57,697,698
Ensembl chr 5:57,691,969...57,697,698
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Tgfb1
transforming growth factor, beta 1
multiple interactions
ISO
Theophylline inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Theophylline inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Theophylline promotes the reaction [Dexamethasone inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]
CTD
PMID:16430859
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tgif1
TGFB-induced factor homeobox 1
increases expression
ISO
Theophylline results in increased expression of TGIF1 mRNA
CTD
PMID:16083514
NCBI chr 9:110,748,094...110,757,714
Ensembl chr 9:110,720,921...110,757,802
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Thrsp
thyroid hormone responsive
decreases expression
EXP
Theophylline results in decreased expression of THRSP mRNA
CTD
PMID:17522070
NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075
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Timp1
TIMP metallopeptidase inhibitor 1
increases expression
EXP
Theophylline results in increased expression of TIMP1 mRNA
CTD
PMID:17522070
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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Tmc5
transmembrane channel-like 5
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TMC5 protein
CTD
PMID:18951874
NCBI chr 1:172,914,915...172,999,478
Ensembl chr 1:172,914,457...172,999,474
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Tmed4
transmembrane p24 trafficking protein 4
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TMED4 protein
CTD
PMID:18951874
NCBI chr14:81,125,049...81,129,646
Ensembl chr14:81,125,053...81,129,631
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Tmem106b
transmembrane protein 106B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TMEM106B protein
CTD
PMID:18951874
NCBI chr 4:41,328,125...41,347,315
Ensembl chr 4:41,327,994...41,345,619
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Tmem19
transmembrane protein 19
decreases expression
ISO
Theophylline results in decreased expression of TMEM19 mRNA
CTD
PMID:18951874
NCBI chr 7:50,958,884...50,985,601
Ensembl chr 7:50,958,888...50,986,809
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Tmem243
transmembrane protein 243
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of TMEM243 protein
CTD
PMID:18951874
NCBI chr 4:24,950,791...24,968,642
Ensembl chr 4:24,950,791...24,968,642
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Tmem260
transmembrane protein 260
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of TMEM260 protein
CTD
PMID:18951874
NCBI chr15:21,734,119...21,804,049
Ensembl chr15:21,734,151...21,806,801
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Tmem63a
transmembrane protein 63a
decreases expression
ISO
Theophylline results in decreased expression of TMEM63A mRNA
CTD
PMID:18951874
NCBI chr13:92,662,872...92,696,186
Ensembl chr13:92,663,968...92,696,183
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Tmem80
transmembrane protein 80
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of TMEM80 protein
CTD
PMID:18951874
NCBI chr 1:196,435,999...196,444,368
Ensembl chr 1:196,436,003...196,444,367 Ensembl chr 1:196,436,003...196,444,367
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Tmem87b
transmembrane protein 87B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TMEM87B protein
CTD
PMID:18951874
NCBI chr 3:116,061,933...116,097,421
Ensembl chr 3:116,062,204...116,097,367
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Tmx3
thioredoxin-related transmembrane protein 3
increases expression
ISO
Theophylline results in increased expression of TMX3 mRNA
CTD
PMID:18951874
NCBI chr18:83,731,777...83,764,719
Ensembl chr18:83,731,868...83,762,263
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Tnf
tumor necrosis factor
decreases secretion multiple interactions
ISO EXP
Theophylline results in decreased secretion of TNF protein [Albuterol co-treated with Theophylline] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Albuterol promotes the reaction [Theophylline inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; Theophylline inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein]]]; Theophylline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Theophylline inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Theophylline inhibits the reaction [TNF protein affects the localization of NFKB1 protein]; Theophylline inhibits the reaction [TNF protein results in increased expression of IL6 protein]; Theophylline inhibits the reaction [TNF protein results in increased expression of RELA protein]; Theophylline inhibits the reaction [Tobacco Smoke Pollution inhibits the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein]]] Theophylline inhibits the reaction [Indomethacin results in increased expression of TNF protein]; Theophylline inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD
PMID:8162974 PMID:10344522 PMID:11694023 PMID:11770011 PMID:16133968 PMID:18951874 PMID:20388727 More...
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfaip8
TNF alpha induced protein 8
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TNFAIP8 protein
CTD
PMID:18951874
NCBI chr18:43,183,854...43,299,512
Ensembl chr18:43,183,916...43,299,517
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Tp53
tumor protein p53
multiple interactions decreases expression
ISO EXP
[Theophylline co-treated with Chlorambucil] results in increased expression of TP53; IL4 protein inhibits the reaction [[Theophylline co-treated with Chlorambucil] results in increased expression of TP53] Theophylline results in decreased expression of TP53 mRNA
CTD
PMID:8822937 PMID:17522070
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Tpmt
thiopurine S-methyltransferase
increases expression
ISO
Theophylline results in increased expression of TPMT mRNA
CTD
PMID:16083514
NCBI chr17:17,644,088...17,662,709
Ensembl chr17:17,644,173...17,662,709
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Tpp2
tripeptidyl peptidase 2
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TPP2 protein
CTD
PMID:18951874
NCBI chr 9:46,046,712...46,128,157
Ensembl chr 9:46,046,632...46,128,157
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Traf1
TNF receptor-associated factor 1
decreases expression
ISO
Theophylline results in decreased expression of TRAF1 mRNA
CTD
PMID:16083514
NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807
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Trmt10a
tRNA methyltransferase 10A
multiple interactions decreases expression
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TRMT10A protein Theophylline results in decreased expression of TRMT10A mRNA
CTD
PMID:18951874
NCBI chr 2:226,669,445...226,684,166
Ensembl chr 2:226,669,832...226,684,151
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Trmt13
tRNA methyltransferase 13 homolog
increases expression
ISO
Theophylline results in increased expression of TRMT13 mRNA
CTD
PMID:18951874
NCBI chr 2:204,533,630...204,547,711
Ensembl chr 2:204,533,632...204,546,843
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Trmt61a
tRNA methyltransferase 61A
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of TRMT61A protein
CTD
PMID:18951874
NCBI chr 6:130,737,230...130,743,251
Ensembl chr 6:130,737,219...130,743,243
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Trpm7
transient receptor potential cation channel, subfamily M, member 7
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TRPM7 protein
CTD
PMID:18951874
NCBI chr 3:114,046,258...114,134,799
Ensembl chr 3:114,046,258...114,135,190
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Ttc3
tetratricopeptide repeat domain 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TTC3 protein
CTD
PMID:18951874
NCBI chr11:33,689,119...33,788,976
Ensembl chr11:33,688,952...33,788,975
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Ttll3
tubulin tyrosine ligase like 3
affects binding
ISO
Theophylline binds to TTLL3 protein
CTD
PMID:18951874
NCBI chr 4:146,532,958...146,558,425
Ensembl chr 4:146,533,953...146,557,889
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Ttn
titin
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TTN protein
CTD
PMID:18951874
NCBI chr 3:61,652,432...61,924,912
Ensembl chr 3:61,652,439...61,924,741
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Tuba1b
tubulin, alpha 1B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of TUBA1B protein
CTD
PMID:18951874
NCBI chr 7:130,090,663...130,093,644
Ensembl chr 7:130,081,032...130,196,186
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Tubd1
tubulin, delta 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TUBD1 protein
CTD
PMID:18951874
NCBI chr10:71,367,936...71,391,387
Ensembl chr10:71,368,133...71,391,266
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Tusc3
tumor suppressor candidate 3
increases expression
ISO
Theophylline results in increased expression of TUSC3 mRNA
CTD
PMID:16083514
NCBI chr16:53,196,195...53,345,241
Ensembl chr16:53,196,195...53,344,781
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Tyr
tyrosinase
increases expression
ISO
Theophylline results in increased expression of TYR mRNA; Theophylline results in increased expression of TYR protein
CTD
PMID:21071833 PMID:32001318
NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
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Tyrp1
tyrosinase-related protein 1
increases expression
ISO
Theophylline results in increased expression of TYRP1 protein
CTD
PMID:32001318
NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516
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Uba1
ubiquitin-like modifier activating enzyme 1
affects expression
EXP
Theophylline affects the expression of UBA1 mRNA
CTD
PMID:16988215
NCBI chr X:1,508,700...1,530,677
Ensembl chr X:1,508,666...1,530,636
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Ube2d3
ubiquitin-conjugating enzyme E2D 3
affects expression
EXP
Theophylline affects the expression of UBE2D3 mRNA
CTD
PMID:16988215
NCBI chr 2:223,868,397...223,899,606
Ensembl chr 2:223,868,730...223,898,081
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Ubfd1
ubiquitin family domain containing 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of UBFD1 protein
CTD
PMID:18951874
NCBI chr 1:176,626,003...176,640,993
Ensembl chr 1:176,625,657...176,640,993
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Ubqln2
ubiquilin 2
increases expression
ISO
Theophylline results in increased expression of UBQLN2 mRNA
CTD
PMID:16083514
NCBI chr X:17,853,086...17,856,505
Ensembl chr X:17,853,114...17,856,505
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Ubr3
ubiquitin protein ligase E3 component n-recognin 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of UBR3 protein
CTD
PMID:18951874
NCBI chr 3:54,649,803...54,806,779
Ensembl chr 3:54,649,992...54,806,247
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Ubtf
upstream binding transcription factor
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of UBTF protein
CTD
PMID:18951874
NCBI chr10:87,258,217...87,274,291
Ensembl chr10:87,258,217...87,272,969
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Uchl1
ubiquitin C-terminal hydrolase L1
affects expression
EXP
Theophylline affects the expression of UCHL1 mRNA
CTD
PMID:16988215
NCBI chr14:41,485,031...41,495,590
Ensembl chr14:41,485,031...41,495,590
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Ufm1
ubiquitin-fold modifier 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of UFM1 protein
CTD
PMID:18951874
NCBI chr 2:137,969,476...137,977,620
Ensembl chr 2:137,966,678...137,978,089 Ensembl chr 2:137,966,678...137,978,089
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Utp15
UTP15, small subunit processome component
increases expression
ISO
Theophylline results in increased expression of UTP15 mRNA
CTD
PMID:18951874
NCBI chr 2:29,594,405...29,612,819
Ensembl chr 2:29,594,941...29,612,773
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Uvrag
UV radiation resistance associated
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of UVRAG protein
CTD
PMID:18951874
NCBI chr 1:153,185,356...153,442,200
Ensembl chr 1:153,185,395...153,442,136
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Vegfc
vascular endothelial growth factor C
increases expression
ISO
Theophylline results in increased expression of VEGFC mRNA
CTD
PMID:16083514
NCBI chr16:37,712,251...37,827,845
Ensembl chr16:37,712,262...37,827,848
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Vps26a
VPS26 retromer complex component A
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of VPS26A protein
CTD
PMID:18951874
NCBI chr20:30,404,320...30,434,266
Ensembl chr20:30,404,325...30,434,131
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Vps35l
VPS35 endosomal protein sorting factor like
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of VPS35L protein
CTD
PMID:18951874
NCBI chr 1:173,076,219...173,179,663
Ensembl chr 1:173,076,099...173,180,610
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Vsx1
visual system homeobox 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of VSX1 protein
CTD
PMID:18951874
NCBI chr 3:139,514,270...139,521,869
Ensembl chr 3:139,514,270...139,521,869
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Wdr20
WD repeat domain 20
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of WDR20 protein
CTD
PMID:18951874
NCBI chr 6:129,751,952...129,821,464
Ensembl chr 6:129,752,014...129,847,339
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Wtap
WT1 associated protein
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of WTAP protein
CTD
PMID:18951874
NCBI chr 1:47,665,965...47,691,067
Ensembl chr 1:47,665,965...47,691,065
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Wwox
WW domain-containing oxidoreductase
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of WWOX protein; [Hydrogen Peroxide co-treated with Theophylline] results in increased expression of WWOX protein
CTD
PMID:18951874
NCBI chr19:42,432,141...43,360,278
Ensembl chr19:42,432,152...43,359,391
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Xiap
X-linked inhibitor of apoptosis
increases expression
ISO
Theophylline results in increased expression of XIAP mRNA
CTD
PMID:18951874
NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700
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Xylb
xylulokinase
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of XYLB protein
CTD
PMID:18951874
NCBI chr 8:119,093,466...119,128,858
Ensembl chr 8:119,096,029...119,128,848
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Yap1
Yes1 associated transcriptional regulator
decreases expression
ISO
Theophylline results in decreased expression of YAP1 mRNA
CTD
PMID:18951874
NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010
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Yipf4
Yip1 domain family, member 4
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of YIPF4 protein
CTD
PMID:18951874
NCBI chr 6:20,950,774...20,962,195
Ensembl chr 6:20,950,501...20,962,229
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Yipf6
Yip1 domain family, member 6
increases expression
ISO
Theophylline results in increased expression of YIPF6 mRNA
CTD
PMID:18951874
NCBI chr X:64,039,602...64,051,715
Ensembl chr X:64,040,952...64,054,702
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Yju2b
YJU2 splicing factor homolog B
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of YJU2B protein
CTD
PMID:18951874
NCBI chr19:23,894,587...23,906,084
Ensembl chr19:23,894,649...23,906,077
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Ythdc1
YTH N6-methyladenosine RNA binding protein C1
increases expression
ISO
Theophylline results in increased expression of YTHDC1 mRNA
CTD
PMID:18951874
NCBI chr14:21,185,438...21,215,934
Ensembl chr14:21,185,440...21,216,028
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Zbtb18
zinc finger and BTB domain containing 18
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ZBTB18 protein
CTD
PMID:18951874
NCBI chr13:89,439,501...89,447,958
Ensembl chr13:89,439,420...89,448,862
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Zbtb25
zinc finger and BTB domain containing 25
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ZBTB25 protein
CTD
PMID:18951874
NCBI chr 6:95,070,699...95,095,888
Ensembl chr 6:95,075,331...95,095,755
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Zbtb45
zinc finger and BTB domain containing 45
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ZBTB45 protein
CTD
PMID:18951874
NCBI chr 1:73,634,895...73,639,802
Ensembl chr 1:73,635,448...73,639,556
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Zcchc10
zinc finger CCHC-type containing 10
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ZCCHC10 protein
CTD
PMID:18951874
NCBI chr10:37,470,628...37,481,027
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Zdhhc11
zinc finger, DHHC-type containing 11
decreases expression
ISO
Theophylline results in decreased expression of ZDHHC11 mRNA
CTD
PMID:18951874
NCBI chr 1:29,296,334...29,327,227
Ensembl chr 1:29,296,334...29,326,898
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Zfand3
zinc finger AN1-type containing 3
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ZFAND3 protein
CTD
PMID:18951874
NCBI chr20:8,083,407...8,279,617
Ensembl chr20:8,082,200...8,279,616
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Zfp24
zinc finger protein 24
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ZNF24 protein
CTD
PMID:18951874
NCBI chr18:15,295,687...15,307,319
Ensembl chr18:15,298,290...15,306,799
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Zfp354a
zinc finger protein 354A
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ZNF354A protein
CTD
PMID:18951874
NCBI chr10:35,396,242...35,408,069
Ensembl chr10:35,396,231...35,408,068
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Zfp866
zinc finger protein 866
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ZNF700 protein
CTD
PMID:18951874
NCBI chr16:19,653,966...19,675,968
Ensembl chr16:19,668,258...19,675,932
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Zfpl1
zinc finger protein-like 1
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ZFPL1 protein
CTD
PMID:18951874
NCBI chr 1:203,374,500...203,378,518
Ensembl chr 1:203,374,504...203,378,487
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Zrsr2
zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2
decreases expression
ISO
Theophylline results in decreased expression of ZRSR2 mRNA
CTD
PMID:18951874
NCBI chr X:30,547,424...30,571,613
Ensembl chr X:30,547,536...30,570,125
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Zxdc
ZXD family zinc finger C
multiple interactions
ISO
[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ZXDC protein
CTD
PMID:18951874
NCBI chr 4:122,882,389...122,914,486
Ensembl chr 4:122,882,336...122,916,496
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Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
thiaton results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Mpo
myeloperoxidase
multiple interactions
EXP
thiaton inhibits the reaction [Indomethacin results in increased activity of MPO protein]
CTD
PMID:11855677
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Nos2
nitric oxide synthase 2
multiple interactions
EXP
thiaton inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]
CTD
PMID:11855677
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
affects metabolic processing increases metabolic processing multiple interactions
ISO
CYP1A2 protein affects the metabolism of tizanidine CYP1A2 protein results in increased metabolism of tizanidine [[Ethinyl Estradiol co-treated with Gestodene] results in decreased activity of CYP1A2 protein] which results in decreased metabolism of tizanidine; Ciprofloxacin inhibits the reaction [CYP1A2 protein affects the metabolism of tizanidine]; rofecoxib inhibits the reaction [CYP1A2 protein results in increased metabolism of tizanidine]
CTD
PMID:15592331 PMID:15834531 PMID:16198659 PMID:16934051 PMID:17618427
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Abcb4
ATP binding cassette subfamily B member 4
decreases activity
ISO
Tolterodine Tartrate results in decreased activity of ABCB4 protein
CTD
PMID:28437613
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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Ahr
aryl hydrocarbon receptor
decreases expression
ISO
Tolterodine Tartrate results in decreased expression of AHR mRNA
CTD
PMID:24316275
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Chrm2
cholinergic receptor, muscarinic 2
multiple interactions
ISO
Tolterodine Tartrate binds to and results in decreased activity of CHRM2 protein
CTD
PMID:15140916
NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
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Chrm3
cholinergic receptor, muscarinic 3
multiple interactions
ISO
Tolterodine Tartrate binds to and results in decreased activity of CHRM3 protein
CTD
PMID:15140916
NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
increases metabolic processing affects metabolic processing multiple interactions
ISO
CYP2D6 protein results in increased metabolism of Tolterodine Tartrate CYP2D6 polymorphism affects the metabolism of Tolterodine Tartrate Fluoxetine inhibits the reaction [CYP2D6 protein results in increased metabolism of Tolterodine Tartrate]
CTD
PMID:10583026 PMID:28087463
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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Il1b
interleukin 1 beta
decreases expression
ISO
Tolterodine Tartrate results in decreased expression of IL1B mRNA
CTD
PMID:32816093
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
multiple interactions decreases expression
ISO
Tolterodine Tartrate inhibits the reaction [Dexamethasone results in increased expression of NR3C1 mRNA] Tolterodine Tartrate results in decreased expression of NR3C1 mRNA
CTD
PMID:24316275
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Tolterodine Tartrate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Slpi
secretory leukocyte peptidase inhibitor
increases expression
ISO
Tolterodine Tartrate results in increased expression of SLPI mRNA
CTD
PMID:32816093
NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
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Abcb1a
ATP binding cassette subfamily B member 1A
multiple interactions increases transport
ISO
valspodar inhibits the reaction [ABCB1 protein results in increased transport of trospium chloride]
CTD
PMID:25466967
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Slc22a1
solute carrier family 22 member 1
decreases activity increases metabolic processing
ISO
trospium chloride results in decreased activity of SLC22A1 protein SLC22A1 protein results in increased metabolism of trospium chloride
CTD
PMID:25466967
NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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Slc22a2
solute carrier family 22 member 2
decreases activity
ISO
trospium chloride results in decreased activity of SLC22A2 protein
CTD
PMID:25466967
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Slco1a4
solute carrier organic anion transporter family, member 1a4
increases metabolic processing decreases activity
ISO
SLCO1A2 protein results in increased metabolism of trospium chloride trospium chloride results in decreased activity of SLCO1A2 protein; trospium chloride results in decreased activity of SLCO1A2 protein alternative form
CTD
PMID:25466967
NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
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Slco1b2
solute carrier organic anion transporter family member 1B2
decreases activity
ISO
trospium chloride results in decreased activity of SLCO1B3 protein
CTD
PMID:25466967
NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
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Ache
acetylcholinesterase
multiple interactions
ISO
Tubocurarine promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; Tubocurarine promotes the reaction [haloxon results in increased phosphorylation of ACHE protein]; Tubocurarine promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein]
CTD
PMID:10421444
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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App
amyloid beta precursor protein
multiple interactions
ISO
Tubocurarine inhibits the reaction [[Nicotine results in increased metabolism of APP protein] which results in increased secretion of APP protein modified form]; Tubocurarine inhibits the reaction [Nicotine results in increased metabolism of APP protein]
CTD
PMID:29618714
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
Tubocurarine inhibits the reaction [PTMA protein results in decreased expression of BCL2]
CTD
PMID:16644063
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bglap
bone gamma-carboxyglutamate protein
multiple interactions
ISO
Tubocurarine inhibits the reaction [Nicotine results in increased expression of BGLAP]
CTD
PMID:19436947
NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
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C7
complement C7
multiple interactions decreases expression
ISO
Tubocurarine inhibits the reaction [Nicotine results in increased expression of C7 mRNA] Tubocurarine results in decreased expression of C7 mRNA
CTD
PMID:16949557
NCBI chr 2:54,088,116...54,165,102
Ensembl chr 2:54,088,116...54,158,535
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Cdk4
cyclin-dependent kinase 4
multiple interactions
ISO
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CDK4 protein]
CTD
PMID:15231866
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
G
Chrna1
cholinergic receptor nicotinic alpha 1 subunit
multiple interactions
ISO
Tubocurarine inhibits the reaction [CHRNA1 protein binds to PLAU protein]
CTD
PMID:19690163
NCBI chr 3:58,454,763...58,469,832
Ensembl chr 3:58,454,744...58,469,840
G
Chrna2
cholinergic receptor nicotinic alpha 2 subunit
multiple interactions
EXP
Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]]
CTD
PMID:7808438
NCBI chr15:40,342,317...40,358,601
Ensembl chr15:40,342,317...40,358,601
G
Chrna3
cholinergic receptor nicotinic alpha 3 subunit
multiple interactions
ISO EXP
Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Tubocurarine inhibits the reaction [desnitroimidacloprid results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]] Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]]; Tubocurarine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]
CTD
PMID:7808438 PMID:9687574 PMID:16931985 PMID:34628512
NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165
G
Chrna4
cholinergic receptor nicotinic alpha 4 subunit
multiple interactions
ISO
Tubocurarine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]]; Tubocurarine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] Tubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]
CTD
PMID:7756618 PMID:11711029 PMID:14645658 PMID:16931985
NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
G
Chrna7
cholinergic receptor nicotinic alpha 7 subunit
multiple interactions
ISO
Tubocurarine binds to and results in decreased activity of CHRNA7 protein; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Tubocurarine inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]
CTD
PMID:10082212 PMID:10216184 PMID:16931985
NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240
G
Chrnb2
cholinergic receptor nicotinic beta 2 subunit
multiple interactions
ISO EXP
Tubocurarine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]]; Tubocurarine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]] Tubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein]
CTD
PMID:7756618 PMID:7808438 PMID:11711029 PMID:14645658 PMID:16931985
NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
G
Chrnb4
cholinergic receptor nicotinic beta 4 subunit
multiple interactions
ISO EXP
Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Tubocurarine inhibits the reaction [desnitroimidacloprid results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]] Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]]; Tubocurarine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]
CTD
PMID:7808438 PMID:9687574 PMID:16931985 PMID:34628512
NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027
G
Cntn1
contactin 1
increases expression decreases expression multiple interactions
ISO
Tubocurarine results in increased expression of CNTN1 mRNA Tubocurarine results in decreased expression of CNTN1 mRNA Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA]
CTD
PMID:12588870 PMID:16949557
NCBI chr 7:123,263,146...123,560,896
Ensembl chr 7:123,372,792...123,558,541
G
Csf2
colony stimulating factor 2
multiple interactions
ISO
Tubocurarine inhibits the reaction [Nicotine results in increased secretion of CSF2 protein]
CTD
PMID:9606035
NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
G
Dhfr
dihydrofolate reductase
multiple interactions decreases expression
ISO
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA] Tubocurarine results in decreased expression of DHFR mRNA
CTD
PMID:12588870
NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713
G
Eml4
EMAP like 4
multiple interactions
ISO
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of EML4 mRNA]
CTD
PMID:12588870
NCBI chr 6:11,219,545...11,334,824
Ensembl chr 6:11,219,566...11,334,879
G
Fas
Fas cell surface death receptor
multiple interactions
ISO
Tubocurarine inhibits the reaction [PTMA protein results in increased expression of FAS]
CTD
PMID:16644063
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
G
Fez1
fasciculation and elongation protein zeta 1
multiple interactions decreases expression
ISO
Tubocurarine promotes the reaction [Nicotine results in decreased expression of FEZ1 mRNA] Tubocurarine results in decreased expression of FEZ1 mRNA
CTD
PMID:12588870
NCBI chr 8:36,544,462...36,589,684
Ensembl chr 8:36,544,535...36,589,683
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
Tubocurarine inhibits the reaction [Nicotine results in increased expression of FOS]
CTD
PMID:11425648
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
G
Golga4
golgin A4
decreases expression multiple interactions
ISO
Tubocurarine results in decreased expression of GOLGA4 mRNA Tubocurarine inhibits the reaction [Nicotine results in increased expression of GOLGA4 mRNA]
CTD
PMID:16949557
NCBI chr 8:118,208,200...118,285,003
G
Il1b
interleukin 1 beta
multiple interactions
ISO
Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 mRNA]]; Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased secretion of CXCL8 protein]]
CTD
PMID:22119045
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Kcnn1
potassium calcium-activated channel subfamily N member 1
decreases activity
ISO
Tubocurarine results in decreased activity of KCNN1 protein
CTD
PMID:10696100
NCBI chr16:18,574,858...18,598,585
Ensembl chr16:18,585,992...18,597,482
G
Kcnn2
potassium calcium-activated channel subfamily N member 2
decreases activity
ISO EXP
Tubocurarine results in decreased activity of KCNN2 protein
CTD
PMID:10696100 PMID:10991935
NCBI chr18:37,817,966...38,258,347
Ensembl chr18:37,817,957...38,258,347
G
Kmt2c
lysine methyltransferase 2C
multiple interactions decreases expression
ISO
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of KMT2C mRNA] Tubocurarine results in decreased expression of KMT2C mRNA
CTD
PMID:12588870
NCBI chr 4:9,620,638...9,834,787
Ensembl chr 4:9,609,627...9,833,539
G
Litaf
lipopolysaccharide-induced TNF factor
multiple interactions
ISO
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of LITAF mRNA]
CTD
PMID:12588870
NCBI chr10:4,656,308...4,692,981
Ensembl chr10:4,625,552...4,692,763
G
Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
Tubocurarine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]
CTD
PMID:22119045
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
Tubocurarine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]
CTD
PMID:22119045
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
G
Mmp1
matrix metallopeptidase 1
multiple interactions
ISO
Tubocurarine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP1 protein]]; Tubocurarine inhibits the reaction [Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 protein]]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of MMP1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of MMP1 protein]
CTD
PMID:17151781 PMID:18986645
NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
G
Nin
ninein
multiple interactions decreases expression
ISO
Tubocurarine inhibits the reaction [Nicotine results in increased expression of NIN mRNA] Tubocurarine results in decreased expression of NIN mRNA
CTD
PMID:16949557
NCBI chr 6:88,525,405...88,627,710
Ensembl chr 6:88,525,742...88,627,639
G
Plau
plasminogen activator, urokinase
multiple interactions
ISO
Tubocurarine inhibits the reaction [CHRNA1 protein binds to PLAU protein]
CTD
PMID:19690163
NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
G
Pou5f1
POU class 5 homeobox 1
decreases expression multiple interactions
ISO
Tubocurarine results in decreased expression of POU5F1 mRNA Tubocurarine inhibits the reaction [Nicotine results in increased expression of POU5F1 mRNA]
CTD
PMID:15612475 PMID:15749260
NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
G
Prkn
parkin RBR E3 ubiquitin protein ligase
decreases expression
ISO
Tubocurarine results in decreased expression of PRKN mRNA
CTD
PMID:16949557
NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
G
Ptma
prothymosin alpha
multiple interactions
ISO
Tubocurarine inhibits the reaction [PTMA protein results in decreased expression of BCL2]; Tubocurarine inhibits the reaction [PTMA protein results in increased expression of FAS]
CTD
PMID:16644063
NCBI chr 9:87,176,251...87,180,333
Ensembl chr 9:87,176,230...87,180,333
G
Ptpra
protein tyrosine phosphatase, receptor type, A
multiple interactions
ISO
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of PTPRA mRNA]
CTD
PMID:12588870
NCBI chr 3:117,650,146...117,759,744
Ensembl chr 3:117,650,183...117,759,728
G
Rbbp6
RB binding protein 6, ubiquitin ligase
multiple interactions
ISO
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of RBBP6 mRNA]
CTD
PMID:12588870
NCBI chr 1:177,503,988...177,537,397
Ensembl chr 1:177,503,313...177,535,678
G
Sftpa1
surfactant protein A1
multiple interactions
ISO
Tubocurarine inhibits the reaction [Nicotine results in increased expression of SFTPA1 mRNA]
CTD
PMID:9458815
NCBI chr16:17,008,180...17,011,686
Ensembl chr16:17,008,180...17,011,685
G
Sftpc
surfactant protein C
multiple interactions
ISO
Tubocurarine inhibits the reaction [Nicotine results in increased expression of SFTPC mRNA]
CTD
PMID:9458815
NCBI chr15:45,596,565...45,599,615
Ensembl chr15:45,596,574...45,610,777
G
Sos1
SOS Ras/Rac guanine nucleotide exchange factor 1
multiple interactions decreases expression
ISO
Tubocurarine inhibits the reaction [Nicotine results in increased expression of SOS1 mRNA] Tubocurarine results in decreased expression of SOS1 mRNA
CTD
PMID:16949557
NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107
G
Spp1
secreted phosphoprotein 1
multiple interactions
ISO
Tubocurarine inhibits the reaction [Nicotine results in increased expression of SPP1 protein]
CTD
PMID:11425648
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
G
Stip1
stress-induced phosphoprotein 1
multiple interactions decreases expression
ISO
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of STIP1 mRNA] Tubocurarine results in decreased expression of STIP1 mRNA
CTD
PMID:16949557
NCBI chr 1:204,209,433...204,228,452
Ensembl chr 1:204,178,932...204,228,476
G
Ube2c
ubiquitin-conjugating enzyme E2C
multiple interactions decreases expression
ISO
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of UBE2C mRNA] Tubocurarine results in decreased expression of UBE2C mRNA
CTD
PMID:16949557
NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339
G
Ube3a
ubiquitin protein ligase E3A
increases expression multiple interactions
ISO
Tubocurarine results in increased expression of UBE3A mRNA Tubocurarine inhibits the reaction [Nicotine results in decreased expression of UBE3A mRNA]
CTD
PMID:12588870
NCBI chr 1:110,070,260...110,161,675
Ensembl chr 1:110,070,480...110,157,250
G
Xdh
xanthine dehydrogenase
multiple interactions
EXP
Tubocurarine inhibits the reaction [Isoflurophate results in increased expression of XDH protein alternative form]
CTD
PMID:9789800
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
G
Zfp42
zinc finger protein 42
multiple interactions
ISO
Tubocurarine inhibits the reaction [Nicotine results in increased expression of ZFP42 mRNA]
CTD
PMID:15749260
NCBI chr16:48,836,463...48,845,443
Ensembl chr16:48,836,648...48,845,401
G
Zfr
zinc finger RNA binding protein
decreases expression multiple interactions
ISO
Tubocurarine results in decreased expression of ZFR mRNA Tubocurarine inhibits the reaction [Nicotine results in decreased expression of ZFR mRNA]
CTD
PMID:12588870
NCBI chr 2:61,137,611...61,200,322
Ensembl chr 2:61,137,611...61,200,322
G
Abca1
ATP binding cassette subfamily A member 1
multiple interactions
ISO
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 protein]
CTD
PMID:30036686
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
G
Abcg1
ATP binding cassette subfamily G member 1
multiple interactions
ISO
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCG1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCG1 protein]
CTD
PMID:30036686
NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
G
Chrm1
cholinergic receptor, muscarinic 1
multiple interactions
ISO
Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]
CTD
PMID:9846649
NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356
G
Chrm2
cholinergic receptor, muscarinic 2
multiple interactions
ISO
Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]
CTD
PMID:9846649
NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
G
Chrm3
cholinergic receptor, muscarinic 3
multiple interactions
ISO
Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]
CTD
PMID:9846649
NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278
G
Chrm4
cholinergic receptor, muscarinic 4
multiple interactions
ISO
Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein]
CTD
PMID:9846649
NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159
G
Chrm5
cholinergic receptor, muscarinic 5
multiple interactions
ISO
Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]
CTD
PMID:9846649
NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252
G
Chrna3
cholinergic receptor nicotinic alpha 3 subunit
multiple interactions
ISO
Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]
CTD
PMID:16931985
NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165
G
Chrna4
cholinergic receptor nicotinic alpha 4 subunit
multiple interactions
ISO
Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
CTD
PMID:14645658 PMID:16931985
NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
G
Chrna7
cholinergic receptor nicotinic alpha 7 subunit
multiple interactions
ISO
Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]
CTD
PMID:16931985
NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240
G
Chrnb2
cholinergic receptor nicotinic beta 2 subunit
multiple interactions
ISO
Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
CTD
PMID:14645658 PMID:16931985
NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
G
Chrnb4
cholinergic receptor nicotinic beta 4 subunit
multiple interactions
ISO
Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]
CTD
PMID:16931985
NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027
G
Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
multiple interactions
ISO
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 protein]
CTD
PMID:31846720
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
G
Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
multiple interactions
ISO
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP19A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP19A1 protein]
CTD
PMID:30959089
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
G
Egr1
early growth response 1
multiple interactions
ISO
Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 protein]
CTD
PMID:29486207
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
G
Elk1
ETS transcription factor ELK1
multiple interactions
ISO
Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of ELK1 protein]
CTD
PMID:29486207
NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713
G
Hdac4
histone deacetylase 4
multiple interactions
ISO
Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 protein]
CTD
PMID:31846720
NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164
G
Hexb
hexosaminidase subunit beta
increases secretion
ISO
Vecuronium Bromide results in increased secretion of HEXB protein
CTD
PMID:19758318
NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223
G
Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
increases expression multiple interactions
ISO
Vecuronium Bromide results in increased expression of HSD11B2 mRNA; Vecuronium Bromide results in increased expression of HSD11B2 protein Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 protein]
CTD
PMID:29486207
NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
G
Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]
CTD
PMID:29486207
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]
CTD
PMID:29486207
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
G
Nr1h2
nuclear receptor subfamily 1, group H, member 2
multiple interactions
ISO
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H2 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H2 protein]
CTD
PMID:30036686
NCBI chr 1:95,041,967...95,047,358
Ensembl chr 1:95,041,967...95,047,377
G
Nr1h3
nuclear receptor subfamily 1, group H, member 3
multiple interactions
ISO
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H3 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H3 protein]
CTD
PMID:30036686
NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
G
Scarb1
scavenger receptor class B, member 1
multiple interactions
ISO
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of SCARB1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of SCARB1 protein]
CTD
PMID:30036686
NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
G
Star
steroidogenic acute regulatory protein
multiple interactions
ISO
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of STAR mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of STAR protein]
CTD
PMID:31846720
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
G
Adra2a
adrenoceptor alpha 2A
multiple interactions
EXP
[BRL 44408 binds to and results in decreased activity of ADRA2A protein] inhibits the reaction [Xylazine inhibits the reaction [Potassium results in increased secretion of Norepinephrine]]
CTD
PMID:11312645
NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
G
Havcr1
hepatitis A virus cellular receptor 1
multiple interactions
ISO
[Ketamine co-treated with Xylazine] results in increased secretion of HAVCR1 protein
CTD
PMID:30538007
NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
G
Lcn2
lipocalin 2
multiple interactions
ISO
[Ketamine co-treated with Xylazine] results in decreased secretion of LCN2 protein
CTD
PMID:30538007
NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
G
Prkaa1
protein kinase AMP-activated catalytic subunit alpha 1
multiple interactions
EXP
[Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA1 mRNA
CTD
PMID:31276069
NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
G
Prkaa2
protein kinase AMP-activated catalytic subunit alpha 2
multiple interactions
EXP
[Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA2 mRNA
CTD
PMID:31276069
NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543
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