muscle relaxant - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	muscle relaxant	go back to main search page
Accession:	CHEBI:51371	browse the term
Definition:	A drug used to produce muscle relaxation (excepting neuromuscular blocking agents). Its primary clinical and therapeutic use is the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. Also used for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in multiple sclerosis.
Synonyms:	related_synonym:	muscle relaxants

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Rat (1323) Mouse (1305) Human (1314) Chinchilla (0) Bonobo (0) Dog (3) Squirrel (0) Pig (4) Green Monkey (0) Naked Mole-rat (0) All
Genes (1323)

(S)-glaucine

term browser

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Object Name

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Evidence

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PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases activity

glaucine results in increased activity of ABCB1 protein

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709

1-hydroxymidazolam

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Object Name

Qualifiers

Evidence

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PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases chemical synthesis
increases glucuronidation
multiple interactions
increases abundance

CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam
CYP3A4 protein results in increased glucuronidation of 1-hydroxymethylmidazolam
[[3-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[5-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[6-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[6-methylflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[7-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[alpha-naphthoflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[artemetin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[beta-Naphthoflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[chrysin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[eupatilin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[flavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[galangin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[nobiletin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[sinensetin analog results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[sinensetin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[tangeretin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [CYP3A4 protein results in increased glucuronidation of 1-hydroxymethylmidazolam] which results in increased abundance of 1-hydroxymethylmidazolam glucuronide; [CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased abundance of 1-hydroxymethylmidazolam; [CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased chemical synthesis of 1-hydroxymethylmidazolam; [L 754394 results in decreased activity of CYP3A4 protein] which results in decreased chemical synthesis of 1-hydroxymethylmidazolam; acacetin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Apigenin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; CYP3A4 protein inhibits the reaction [Rifampin results in decreased chemical synthesis of 1-hydroxymethylmidazolam]; diosmetin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; erdafitinib inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; flavanone promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; flavone promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; galangin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased abundance of 1-hydroxymethylmidazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Luteolin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; NADP deficiency inhibits the reaction [erdafitinib inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]]; Rifampin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Rifampin promotes the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Verapamil inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]

PMID:10997946 PMID:12401345 PMID:12695342 PMID:18191104 PMID:20233841 More...

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 9

increases chemical synthesis
multiple interactions

CYP3A5 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam
[CYP3A5 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; erdafitinib inhibits the reaction [[CYP3A5 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]

PMID:18191104 PMID:26958860 PMID:34189909

NCBI chr12:21,919,955...21,960,160
Ensembl chr12:16,806,207...16,846,422

G

translocator protein

affects binding

1-hydroxymethylmidazolam binds to TSPO protein; 1-hydroxymethylmidazolam metabolite binds to TSPO protein

NCBI chr 7:116,600,214...116,610,461
Ensembl chr 7:114,720,188...114,730,450

1-hydroxymidazolam beta-D-glucuronide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

[CYP3A4 protein results in increased glucuronidation of 1-hydroxymethylmidazolam] which results in increased abundance of 1-hydroxymethylmidazolam glucuronide

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008

3-hydroxyquinine

term browser

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Object Name

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PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 3, subfamily a, polypeptide 2

affects chemical synthesis

CYP3A4 protein affects the chemical synthesis of 3-hydroxyquinidine

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008

4-hydroxymidazolam

term browser

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Object Name

Qualifiers

Evidence

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Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases chemical synthesis
multiple interactions

CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam
[CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased abundance of 4-hydroxymidazolam; [CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam; acacetin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; Apigenin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; CYP3A4 protein inhibits the reaction [Rifampin results in decreased chemical synthesis of 4-hydroxymidazolam]; diosmetin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam]; flavanone inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; flavone inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; galangin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam]; Luteolin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam]; Rifampin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam]

PMID:12695342 PMID:18191104 PMID:21053930 PMID:27485346

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 9

increases chemical synthesis
multiple interactions

CYP3A5 protein results in increased chemical synthesis of 4-hydroxymidazolam
diosmetin inhibits the reaction [CYP3A5 protein results in increased chemical synthesis of 4-hydroxymidazolam]; Luteolin inhibits the reaction [CYP3A5 protein results in increased chemical synthesis of 4-hydroxymidazolam]

NCBI chr12:21,919,955...21,960,160
Ensembl chr12:16,806,207...16,846,422

8-bromo-3',5'-cyclic GMP

term browser

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Object Name

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Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Rho guanine nucleotide exchange factor 17

multiple interactions

[8-bromocyclic GMP co-treated with PRKG1 protein co-treated with ARHGEF17 protein] results in increased activity of SRF protein

NCBI chr 1:164,642,690...164,702,241
Ensembl chr 1:155,233,168...155,290,498

G

caspase 3

multiple interactions

8-bromocyclic GMP inhibits the reaction [TNF protein results in increased activity of CASP3 protein]; KT 5823 inhibits the reaction [8-bromocyclic GMP inhibits the reaction [TNF protein results in increased activity of CASP3 protein]]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

cytochrome c oxidase subunit 4i1

increases expression
multiple interactions

8-bromocyclic GMP results in increased expression of COX4I1 protein
tin protoporphyrin IX inhibits the reaction [8-bromocyclic GMP results in increased expression of COX4I1 protein]

NCBI chr19:65,630,383...65,636,623
Ensembl chr19:48,721,199...48,727,921

G

dual specificity phosphatase 10

increases expression

8-bromocyclic GMP results in increased expression of DUSP10 mRNA; 8-bromocyclic GMP results in increased expression of DUSP10 protein

NCBI chr13:98,145,317...98,183,304
Ensembl chr13:95,614,292...95,651,716

G

endothelin 1

multiple interactions

8-bromocyclic GMP inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein]
8-bromocyclic GMP inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]; 8-bromocyclic GMP inhibits the reaction [cobaltous chloride results in increased expression of EDN1 protein]

PMID:16023617 PMID:29165873

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885

G

endothelin 3

multiple interactions

8-bromocyclic GMP inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein]

NCBI chr 3:183,980,458...184,004,958
Ensembl chr 3:163,562,520...163,585,093

G

endothelin receptor type B

multiple interactions

8-bromocyclic GMP inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein]; 8-bromocyclic GMP inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein]

NCBI chr15:87,055,490...87,086,765
Ensembl chr15:80,643,043...80,672,115

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

8-bromocyclic GMP inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]; 8-bromocyclic GMP inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261

G

heme oxygenase 1

increases expression

8-bromocyclic GMP results in increased expression of HMOX1 mRNA; 8-bromocyclic GMP results in increased expression of HMOX1 protein

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079

G

interleukin 1 beta

multiple interactions

8-bromocyclic GMP promotes the reaction [IL1B protein results in increased abundance of Nitrites]; Dipyridamole promotes the reaction [8-bromocyclic GMP promotes the reaction [IL1B protein results in increased abundance of Nitrites]]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 4

increases expression
multiple interactions

8-bromocyclic GMP results in increased expression of IL4 mRNA
Cyclosporine inhibits the reaction [8-bromocyclic GMP results in increased expression of IL4 mRNA]

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750

G

mitogen activated protein kinase 1

decreases phosphorylation

8-bromocyclic GMP results in decreased phosphorylation of MAPK1 protein

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

decreases phosphorylation

8-bromocyclic GMP results in decreased phosphorylation of MAPK3 protein

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

MYC proto-oncogene, bHLH transcription factor

decreases phosphorylation

8-bromocyclic GMP results in decreased phosphorylation of MYC protein

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630

G

NADH:ubiquinone oxidoreductase subunit B8

increases expression
multiple interactions

8-bromocyclic GMP results in increased expression of NDUFB8 protein
tin protoporphyrin IX inhibits the reaction [8-bromocyclic GMP results in increased expression of NDUFB8 protein]

NCBI chr 1:253,357,878...253,362,936
Ensembl chr 1:243,408,619...243,413,817

G

nuclear factor of activated T-cells 1

affects localization

8-bromocyclic GMP affects the localization of NFATC1 protein

NCBI chr18:76,321,386...76,430,997
Ensembl chr18:74,046,904...74,156,028

G

nuclear respiratory factor 1

increases expression
multiple interactions

8-bromocyclic GMP results in increased expression of NRF1 mRNA
tin protoporphyrin IX inhibits the reaction [8-bromocyclic GMP results in increased expression of NRF1 mRNA]

NCBI chr 4:59,632,366...59,738,166
Ensembl chr 4:58,664,957...58,825,328

G

phosphodiesterase 5A

multiple interactions

[1-Methyl-3-isobutylxanthine co-treated with 8-bromocyclic GMP] results in increased expression of PDE5A protein; [1-Methyl-3-isobutylxanthine co-treated with 8-bromocyclic GMP] results in increased expression of PDE5A protein modified form

NCBI chr 2:213,542,822...213,687,638
Ensembl chr 2:210,858,063...210,999,701

G

PPARG coactivator 1 alpha

increases expression
multiple interactions

8-bromocyclic GMP results in increased expression of PPARGC1A mRNA
tin protoporphyrin IX inhibits the reaction [8-bromocyclic GMP results in increased expression of PPARGC1A mRNA]

NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656

G

protein kinase cGMP-dependent 1

increases expression
multiple interactions

8-bromocyclic GMP results in increased expression of PRKG1 protein
[8-bromocyclic GMP co-treated with PRKG1 protein co-treated with ARHGEF17 protein] results in increased activity of SRF protein

PMID:12620371 PMID:23195829

NCBI chr 1:237,818,950...239,052,184
Ensembl chr 1:228,408,947...229,639,080

G

sodium channel epithelial 1 subunit beta

multiple interactions

[1-Methyl-3-isobutylxanthine co-treated with 8-bromocyclic GMP] results in increased expression of SCNN1B protein

NCBI chr 1:185,861,326...185,915,717
Ensembl chr 1:176,430,103...176,484,451

G

superoxide dismutase 2

increases expression

8-bromocyclic GMP results in increased expression of SOD2 mRNA; 8-bromocyclic GMP results in increased expression of SOD2 protein

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189

G

secreted phosphoprotein 1

multiple interactions

8-bromocyclic GMP inhibits the reaction [Glucose results in increased secretion of SPP1 protein]; Dinitrochlorobenzene inhibits the reaction [8-bromocyclic GMP inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; KT 5823 inhibits the reaction [8-bromocyclic GMP inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [8-bromocyclic GMP inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162

G

serum response factor

multiple interactions

[8-bromocyclic GMP co-treated with PRKG1 protein co-treated with ARHGEF17 protein] results in increased activity of SRF protein

NCBI chr 9:21,924,050...21,933,338
Ensembl chr 9:14,426,472...14,435,733

G

somatostatin

decreases secretion

8-bromocyclic GMP results in decreased secretion of SST protein

NCBI chr11:90,461,546...90,462,823
Ensembl chr11:76,956,896...76,958,173

G

transcription factor A, mitochondrial

increases expression
multiple interactions

8-bromocyclic GMP results in increased expression of TFAM mRNA
tin protoporphyrin IX inhibits the reaction [8-bromocyclic GMP results in increased expression of TFAM mRNA]

NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,356,197...17,368,292

G

tyrosine hydroxylase

multiple interactions

8-bromocyclic GMP inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein]; 8-bromocyclic GMP inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein]

NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767

G

tumor necrosis factor

multiple interactions

8-bromocyclic GMP inhibits the reaction [TNF protein results in increased activity of CASP3 protein]; KT 5823 inhibits the reaction [8-bromocyclic GMP inhibits the reaction [TNF protein results in increased activity of CASP3 protein]]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

increases expression

8-bromocyclic GMP results in increased expression of TP53 protein

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524

G

transient receptor potential cation channel, subfamily C, member 6

multiple interactions
increases phosphorylation

8-bromocyclic GMP inhibits the reaction [1-oleoyl-2-acetylglycerol results in increased activity of TRPC6 protein]
8-bromocyclic GMP results in increased phosphorylation of TRPC6 protein
KT 5823 inhibits the reaction [8-bromocyclic GMP results in increased phosphorylation of TRPC6 protein]

NCBI chr 8:14,044,216...14,148,808
Ensembl chr 8:5,758,935...5,828,092

G

thioredoxin 1

multiple interactions

8-bromocyclic GMP inhibits the reaction [Glucose results in decreased expression of TXN1 protein]

NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:72,711,933...72,724,629

G

ubiquinol-cytochrome c reductase core protein 1

multiple interactions
increases expression

tin protoporphyrin IX inhibits the reaction [8-bromocyclic GMP results in increased expression of UQCRC1 protein]

NCBI chr 8:118,468,223...118,479,968
Ensembl chr 8:109,589,706...109,601,480

G

vascular cell adhesion molecule 1

decreases expression

8-bromocyclic GMP results in decreased expression of VCAM1 protein

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958

G

vascular endothelial growth factor A

decreases expression

8-bromocyclic GMP results in decreased expression of VEGFA protein

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641

alcuronium

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cholinergic receptor, muscarinic 4

multiple interactions
affects binding

WIN 62577 inhibits the reaction [Alcuronium binds to CHRM4 protein]

NCBI chr 3:98,349,080...98,356,821
Ensembl chr 3:77,893,425...77,901,159

G

cholinergic receptor nicotinic alpha 4 subunit

multiple interactions

Alcuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Alcuronium results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]

NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:168,136,266...168,156,957

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

Alcuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Alcuronium results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]

NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:175,181,402...175,189,619

alprazolam

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

calpain 1

multiple interactions

[Caffeine co-treated with Alprazolam] promotes the reaction [Calcium results in increased activity of CAPN1 protein]

NCBI chr 1:212,705,219...212,736,134
Ensembl chr 1:203,277,344...203,300,177

G

caspase 3

multiple interactions

[Caffeine co-treated with Alprazolam] results in increased cleavage of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

cathepsin B

multiple interactions

[Caffeine co-treated with Alprazolam] results in increased secretion of CTSB protein

NCBI chr15:41,565,607...41,586,479
Ensembl chr15:37,389,629...37,410,500

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
affects metabolic processing

CYP3A4 protein binds to and affects the metabolism of Alprazolam
CYP3A4 protein affects the metabolism of Alprazolam

PMID:12196913 PMID:15856409 PMID:16042670

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

affects metabolic processing

CYP3A23-3A1 protein affects the metabolism of Alprazolam

NCBI chr12:14,369,950...14,398,803
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

cytochrome P450, family 3, subfamily a, polypeptide 9

increases hydroxylation

CYP3A5 protein results in increased hydroxylation of Alprazolam

NCBI chr12:21,919,955...21,960,160
Ensembl chr12:16,806,207...16,846,422

G

interleukin 2

decreases expression

Alprazolam results in decreased expression of IL2 protein

NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566

G

luteinizing hormone subunit beta

increases secretion

Alprazolam results in increased secretion of LHB protein

NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

poly (ADP-ribose) polymerase 1

multiple interactions

[Caffeine co-treated with Alprazolam] results in increased activity of PARP1 protein

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404

G

phospholipase C beta 1

decreases expression

Alprazolam results in decreased expression of PLCB1 mRNA; Alprazolam results in decreased expression of PLCB1 protein

NCBI chr 3:142,512,765...143,224,042
Ensembl chr 3:122,060,031...122,772,869

G

peptidylprolyl isomerase A

increases hydroxylation

PPIA protein results in increased hydroxylation of Alprazolam

NCBI chr14:85,491,223...85,496,884
Ensembl chr14:81,275,091...81,299,601

G

solute carrier family 22 member 2

multiple interactions

Alprazolam inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268

G

thyrotropin releasing hormone

multiple interactions

Alprazolam inhibits the reaction [TRH protein modified form binds to TRHR protein]

NCBI chr 4:126,299,236...126,301,762
Ensembl chr 4:124,742,111...124,744,637

G

thyrotropin releasing hormone receptor

multiple interactions

Alprazolam inhibits the reaction [TRH protein modified form binds to TRHR protein]

NCBI chr 7:77,233,175...77,277,988
Ensembl chr 7:75,348,672...75,393,309

alverine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

5-hydroxytryptamine receptor 1A

affects binding

alverine binds to HTR1A protein

NCBI chr 2:38,427,169...38,431,733
Ensembl chr 2:36,694,174...36,695,442

G

potassium voltage-gated channel subfamily H member 2

decreases activity

alverine results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008

aminophylline

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldehyde dehydrogenase 18 family, member A1

increases expression

Aminophylline results in increased expression of ALDH18A1 mRNA

NCBI chr 1:249,325,082...249,357,383
Ensembl chr 1:239,375,669...239,407,890

G

BCL2, apoptosis regulator

multiple interactions

[Aminophylline co-treated with Gemcitabine] results in decreased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

catalase

multiple interactions

[Aminophylline co-treated with Photosensitizing Agents] promotes the reaction [Benzo(a)pyrene results in increased expression of CAT protein]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478

G

glucagon

increases secretion

Aminophylline results in increased secretion of GCG protein

NCBI chr 3:67,522,489...67,531,533
Ensembl chr 3:47,113,914...47,122,929

G

histamine receptor H 1

multiple interactions

[Astemizole binds to and results in decreased activity of HRH1 protein] which affects the susceptibility to Aminophylline

NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:147,645,995...147,647,455

G

insulin 1

increases secretion

Aminophylline results in increased secretion of INS1 protein

NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536

atracurium

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cholinergic receptor nicotinic alpha 3 subunit

multiple interactions

Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]

NCBI chr 8:64,297,755...64,311,251
Ensembl chr 8:55,401,702...55,415,165

G

cholinergic receptor nicotinic alpha 4 subunit

multiple interactions

Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]

NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:168,136,266...168,156,957

G

cholinergic receptor nicotinic alpha 7 subunit

multiple interactions

Atracurium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]

NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]

NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:175,181,402...175,189,619

G

cholinergic receptor nicotinic beta 4 subunit

multiple interactions

Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]

NCBI chr 8:64,312,644...64,333,319
Ensembl chr 8:55,418,313...55,437,027

G

hexosaminidase subunit beta

increases secretion

Atracurium results in increased secretion of HEXB protein

NCBI chr 2:30,218,608...30,238,771
Ensembl chr 2:28,484,012...28,504,223

baclofen

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 4

increases transport

ABCC4 protein results in increased transport of Baclofen

NCBI chr15:101,948,387...102,182,912
Ensembl chr15:95,542,315...95,774,283

G

CF transmembrane conductance regulator

multiple interactions

Baclofen promotes the reaction [Isoproterenol results in increased activity of CFTR protein]

NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:46,560,885...46,728,756

G

cAMP responsive element binding protein 1

multiple interactions

Baclofen inhibits the reaction [Amphetamine affects the phosphorylation of CREB1 protein]

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816

G

dopamine receptor D3

decreases expression

Baclofen results in decreased expression of DRD3 mRNA

NCBI chr11:70,385,586...70,437,793
Ensembl chr11:56,879,689...56,940,596

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Baclofen inhibits the reaction [Cocaine results in increased expression of FOS protein]

PMID:16710312 PMID:16930414

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036

G

follicle stimulating hormone subunit beta

decreases expression
multiple interactions

Baclofen results in decreased expression of FSHB protein
Baclofen inhibits the reaction [Diethylhexyl Phthalate results in increased expression of FSHB protein]

NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:93,548,560...93,552,370

G

gamma-aminobutyric acid type B receptor subunit 1

increases response to substance

GABBR1 results in increased susceptibility to Baclofen

PMID:16990508 PMID:20138995

NCBI chr20:1,469,779...1,499,352
Ensembl chr20:1,464,534...1,493,994

G

gamma-aminobutyric acid type B receptor subunit 2

increases response to substance

GABBR2 results in increased susceptibility to Baclofen

NCBI chr 5:65,743,073...66,083,695
Ensembl chr 5:60,947,526...61,288,104

G

potassium inwardly-rectifying channel, subfamily J, member 6

increases response to substance

KCNJ6 results in increased susceptibility to Baclofen

NCBI chr11:47,531,312...47,778,348
Ensembl chr11:34,061,708...34,308,758

G

luteinizing hormone subunit beta

decreases expression
multiple interactions

Baclofen results in decreased expression of LHB protein
Baclofen inhibits the reaction [Diethylhexyl Phthalate results in increased expression of LHB protein]

NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

monoamine oxidase B

multiple interactions

Baclofen affects the reaction [MAOB gene mutant form results in decreased susceptibility to Amphetamine]

NCBI chr X:8,490,405...8,594,065
Ensembl chr X:5,907,266...6,011,003

G

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions

Baclofen results in increased phosphorylation of MAPK1 protein
CGP 56999A inhibits the reaction [Baclofen results in increased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

CGP 56999A inhibits the reaction [Baclofen results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

prodynorphin

multiple interactions

Baclofen inhibits the reaction [Amphetamine results in increased expression of PDYN mRNA]

PMID:15033416 PMID:15592348

NCBI chr 3:137,354,161...137,366,503
Ensembl chr 3:116,900,992...116,913,334

G

proenkephalin

multiple interactions

Baclofen inhibits the reaction [Amphetamine results in increased expression of PENK mRNA]

PMID:15033416 PMID:15592348

NCBI chr 5:21,981,381...21,987,074
Ensembl chr 5:17,183,806...17,189,129

G

ryanodine receptor 1

multiple interactions

Baclofen inhibits the reaction [A 68930 results in increased expression of RYR1 protein]; Baclofen inhibits the reaction [SK&F 82958 results in increased expression of RYR1 protein]

NCBI chr 1:93,420,078...93,551,305
Ensembl chr 1:84,292,578...84,423,812

G

ryanodine receptor 2

multiple interactions

Baclofen inhibits the reaction [A 68930 results in increased expression of RYR2 protein]; Baclofen inhibits the reaction [SK&F 82958 results in increased expression of RYR2 protein]

NCBI chr17:63,081,527...63,667,141
Ensembl chr17:58,389,925...58,975,142

G

secretogranin II

multiple interactions

Baclofen inhibits the reaction [Amphetamine results in increased expression of SCG2 mRNA]

PMID:15033416 PMID:15592348

NCBI chr 9:88,251,531...88,257,208
Ensembl chr 9:80,803,075...80,821,097

G

tachykinin, precursor 1

multiple interactions

Baclofen inhibits the reaction [Amphetamine results in increased expression of TAC1 mRNA]

NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:35,679,704...35,687,178

G

tumor necrosis factor

decreases secretion

Baclofen results in decreased secretion of TNF protein

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

butylscopolamine bromide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 22 member 2

multiple interactions

Butylscopolammonium Bromide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268

carisoprodol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions

[CYP2C19 gene polymorphism affects the metabolism of Carisoprodol] which affects the chemical synthesis of Meprobamate; [CYP2C19 protein results in increased metabolism of Carisoprodol] which results in increased chemical synthesis of Meprobamate

PMID:12835613 PMID:22527345

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596

G

gamma-aminobutyric acid type A receptor subunit alpha 1

multiple interactions

Bemegride inhibits the reaction [Carisoprodol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Carisoprodol binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]

NCBI chr10:27,096,731...27,152,563
Ensembl chr10:26,595,160...26,650,864

G

gamma-aminobutyric acid type A receptor subunit beta 2

multiple interactions

Bemegride inhibits the reaction [Carisoprodol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Carisoprodol binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]

NCBI chr10:27,438,127...27,657,680
Ensembl chr10:26,936,551...27,151,251

G

gamma-aminobutyric acid type A receptor subunit gamma 2

multiple interactions

Bemegride inhibits the reaction [Carisoprodol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Carisoprodol binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]

NCBI chr10:26,876,926...26,965,523
Ensembl chr10:26,374,694...26,464,346

chlorphenesin carbamate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 22 member 2

multiple interactions

chlorphenesin carbamate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268

chlorzoxazone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome b5 type A

multiple interactions

CYB5A protein promotes the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]

NCBI chr18:80,487,923...80,520,544
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535

G

cytochrome P450, family 1, subfamily a, polypeptide 1

affects metabolic processing

CYP1A1 protein affects the metabolism of Chlorzoxazone

PMID:15231049 PMID:15879494

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

affects metabolic processing
increases hydroxylation

CYP1A2 protein affects the metabolism of Chlorzoxazone
CYP1A2 protein results in increased hydroxylation of Chlorzoxazone

PMID:11911841 PMID:14586387 PMID:15879494

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

Chlorzoxazone results in decreased activity of CYP1B1 protein

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily b, polypeptide 1

affects metabolic processing

CYP2B1 protein affects the metabolism of Chlorzoxazone

NCBI chr 1:90,646,098...90,669,762
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, subfamily 2, polypeptide 11

affects metabolic processing

CYP2C11 protein affects the metabolism of Chlorzoxazone

NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily c, polypeptide 13

affects metabolic processing

CYP2C13 protein affects the metabolism of Chlorzoxazone

NCBI chr 1:248,706,787...248,787,239
Ensembl chr 1:238,786,765...238,867,191

G

cytochrome P450, family 2, subfamily C, polypeptide 6

affects metabolic processing

CYP2C6 protein affects the metabolism of Chlorzoxazone

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily e, polypeptide 1

affects hydroxylation
increases metabolic processing
increases hydroxylation
multiple interactions
affects metabolic processing
increases oxidation

CYP2E1 protein affects the hydroxylation of Chlorzoxazone
CYP2E1 protein results in increased metabolism of Chlorzoxazone
CYP2E1 protein results in increased hydroxylation of Chlorzoxazone
[CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased abundance of 6-hydroxychlorzoxazone; [CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone; Resveratrol inhibits the reaction [CYP2E1 protein results in increased metabolism of Chlorzoxazone]
CYP2E1 mRNA results in increased metabolism of Chlorzoxazone; CYP2E1 protein results in increased metabolism of Chlorzoxazone
CYP2E1 protein affects the metabolism of Chlorzoxazone
[CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone; Imidazoles inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; Isoquinolines inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; Pyridines inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; Quinolines inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]
CYP2E1 protein results in increased oxidation of Chlorzoxazone
[5-bromotryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [5-chlorotryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [5-fluoro-alpha-methyltryptamine results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [5-fluorotryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [5-methyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [7-methyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [Chlormethiazole results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [Chlorzoxazone results in decreased activity of CYP2E1 protein] which results in decreased degradation of vanoxerine; [CYP2E1 mRNA results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone; [CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone; [indopan analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [indopan results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [Methoxydimethyltryptamines analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [N,N-diisopropyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [Tryptamines analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; Carbaryl inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; chlorfluazuron inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; Chlorpyrifos inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; CYB5A protein promotes the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; cypermethrin inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; Disulfiram inhibits the reaction [[CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone]; Disulfiram inhibits the reaction [CYP2E1 protein results in increased metabolism of Chlorzoxazone]; Fenitrothion inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; fenvalerate inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; Fomepizole inhibits the reaction [CYP2E1 protein results in increased metabolism of Chlorzoxazone]; isoproturon inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; Malathion inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; perfluorooctane sulfonic acid inhibits the reaction [CYP2E1 protein results in increased oxidation of Chlorzoxazone]; phenthoate inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]; profenofos inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]

PMID:7747284 PMID:8558417 PMID:8858968 PMID:9817075 PMID:9825833 More...

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

affects metabolic processing

CYP3A2 protein affects the metabolism of Chlorzoxazone

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

increases hydroxylation
affects metabolic processing

CYP3A23-3A1 protein results in increased hydroxylation of Chlorzoxazone
CYP3A23-3A1 protein affects the metabolism of Chlorzoxazone

PMID:11911841 PMID:15879494

NCBI chr12:14,369,950...14,398,803
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

cytochrome P450, family 3, subfamily a, polypeptide 9

affects metabolic processing

CYP3A9 protein affects the metabolism of Chlorzoxazone

NCBI chr12:21,919,955...21,960,160
Ensembl chr12:16,806,207...16,846,422

G

insulin 2

multiple interactions

INS protein inhibits the reaction [stearic acid results in increased hydroxylation of Chlorzoxazone]

NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:197,843,281...197,864,775

G

potassium calcium-activated channel subfamily N member 4

increases activity

Chlorzoxazone results in increased activity of KCNN4 protein

NCBI chr 1:89,084,306...89,102,279
Ensembl chr 1:79,959,322...79,974,340

G

N-acetyltransferase 2

affects metabolic processing

NAT2 protein affects the metabolism of Chlorzoxazone

NCBI chr16:26,974,874...27,005,191
Ensembl chr16:22,208,194...22,238,520

G

xanthine dehydrogenase

affects metabolic processing

XDH protein affects the metabolism of Chlorzoxazone

NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:21,530,113...21,592,268

cisatracurium

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cadherin 1

multiple interactions
increases expression

CXCR4 protein inhibits the reaction [cisatracurium results in increased expression of CDH1 protein]; TGFB1 protein inhibits the reaction [cisatracurium results in increased expression of CDH1 protein]

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775

G

cadherin 2

decreases expression
multiple interactions

cisatracurium results in decreased expression of CDH2 protein
CXCR4 protein inhibits the reaction [cisatracurium results in decreased expression of CDH2 protein]; TGFB1 protein inhibits the reaction [cisatracurium results in decreased expression of CDH2 protein]

NCBI chr18:8,051,097...8,265,288
Ensembl chr18:7,776,704...7,990,167

G

cholinergic receptor nicotinic alpha 3 subunit

multiple interactions

cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]

NCBI chr 8:64,297,755...64,311,251
Ensembl chr 8:55,401,702...55,415,165

G

cholinergic receptor nicotinic alpha 4 subunit

multiple interactions

cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]

NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:168,136,266...168,156,957

G

cholinergic receptor nicotinic alpha 7 subunit

multiple interactions

cisatracurium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]

NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]

NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:175,181,402...175,189,619

G

cholinergic receptor nicotinic beta 4 subunit

multiple interactions

cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]

NCBI chr 8:64,312,644...64,333,319
Ensembl chr 8:55,418,313...55,437,027

G

C-X-C motif chemokine receptor 4

decreases expression
decreases expression
multiple interactions

cisatracurium results in decreased expression of CXCR4 mRNA; cisatracurium results in decreased expression of CXCR4 protein
cisatracurium decreases expression of CXCR4 mRNA and protein in colonic epithelium
CXCR4 protein inhibits the reaction [cisatracurium results in decreased expression of CDH2 protein]; CXCR4 protein inhibits the reaction [cisatracurium results in decreased expression of VIM protein]; CXCR4 protein inhibits the reaction [cisatracurium results in increased expression of CDH1 protein]; TGFB1 protein inhibits the reaction [cisatracurium results in decreased expression of CXCR4 protein]

CTD
RGD

PMID:33617803 PMID:33617803

NCBI chr13:42,630,383...42,634,288
Ensembl chr13:40,077,976...40,081,883

G

transforming growth factor, beta 1

multiple interactions
decreases expression

TGFB1 protein inhibits the reaction [cisatracurium results in decreased expression of CDH2 protein]; TGFB1 protein inhibits the reaction [cisatracurium results in decreased expression of CXCR4 protein]; TGFB1 protein inhibits the reaction [cisatracurium results in decreased expression of TGFBR1 protein]; TGFB1 protein inhibits the reaction [cisatracurium results in decreased expression of VIM protein]; TGFB1 protein inhibits the reaction [cisatracurium results in increased expression of CDH1 protein]
cisatracurium results in decreased expression of TGFB1 protein

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta receptor 1

decreases expression
multiple interactions

cisatracurium results in decreased expression of TGFBR1 protein
TGFB1 protein inhibits the reaction [cisatracurium results in decreased expression of TGFBR1 protein]

NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:61,653,233...61,710,777

G

vimentin

decreases expression
multiple interactions

cisatracurium results in decreased expression of VIM protein
CXCR4 protein inhibits the reaction [cisatracurium results in decreased expression of VIM protein]; TGFB1 protein inhibits the reaction [cisatracurium results in decreased expression of VIM protein]

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187

clidinium

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 22 member 2

multiple interactions

clidinium inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268

cyclobenzaprine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 22 member 2

multiple interactions

cyclobenzaprine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268

dantrolene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily G member 2

affects transport

ABCG2 protein affects the transport of Dantrolene

NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:87,745,319...87,802,409

G

angiotensin converting enzyme 2

increases expression

Dantrolene results in increased expression of ACE2 mRNA

NCBI chr X:33,925,458...33,972,851
Ensembl chr X:30,293,589...30,340,977

G

activating transcription factor 4

decreases expression
multiple interactions

Dantrolene results in decreased expression of ATF4 protein
Dantrolene affects the reaction [perfluorooctanoic acid results in increased expression of ATF4 protein]; Dantrolene inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; Dantrolene promotes the reaction [Thapsigargin results in increased expression of ATF4 mRNA]

PMID:15921666 PMID:32578922

NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:111,804,183...111,806,446

G

BCL2 associated X, apoptosis regulator

multiple interactions

Dantrolene inhibits the reaction [Halothane results in increased expression of BAX mRNA]

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

increases expression

Dantrolene results in increased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 11

multiple interactions

Dantrolene inhibits the reaction [Halothane results in increased expression of BCL2L11 mRNA]

NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:115,366,646...115,404,068

G

brain-derived neurotrophic factor

multiple interactions

Dantrolene inhibits the reaction [Oxygen deficiency results in increased secretion of BDNF protein]

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615

G

calpain 1

decreases expression

Dantrolene results in decreased expression of CAPN1 mRNA; Dantrolene results in decreased expression of CAPN1 protein

NCBI chr 1:212,705,219...212,736,134
Ensembl chr 1:203,277,344...203,300,177

G

calpain 2

decreases expression

Dantrolene results in decreased expression of CAPN2 mRNA; Dantrolene results in decreased expression of CAPN2 protein

NCBI chr13:96,681,902...96,732,625
Ensembl chr13:94,150,240...94,200,969

G

calpain 3

decreases expression

Dantrolene results in decreased expression of CAPN3 mRNA; Dantrolene results in decreased expression of CAPN3 protein

NCBI chr 3:127,860,002...127,913,677
Ensembl chr 3:107,407,850...107,457,858

G

caspase 3

multiple interactions

Dantrolene inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]
Dantrolene inhibits the reaction [Indomethacin results in increased activity of CASP3 protein]

PMID:17079870 PMID:23022152

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

multiple interactions

Dantrolene inhibits the reaction [Indomethacin results in increased activity of CASP9 protein]

Ensembl chr 5:154,109,046...154,126,626

G

C-C motif chemokine ligand 2

decreases expression

Dantrolene results in decreased expression of CCL2 mRNA

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 5

affects expression

Dantrolene affects the expression of CCL5 protein

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377

G

C-X-C motif chemokine ligand 2

multiple interactions

Dantrolene inhibits the reaction [Halothane results in increased expression of CXCL2 mRNA]

NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,181,062...17,183,075

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

Dantrolene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

Dantrolene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312

G

DNA-damage inducible transcript 3

decreases phosphorylation
multiple interactions

Dantrolene results in decreased phosphorylation of DDIT3 protein
Dantrolene inhibits the reaction [Halothane results in increased expression of DDIT3 mRNA]; Dantrolene promotes the reaction [perfluorooctanoic acid results in increased expression of DDIT3 mRNA]; Dantrolene promotes the reaction [perfluorooctanoic acid results in increased expression of DDIT3 protein]

PMID:15921666 PMID:32578922 PMID:32795494

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201

G

endothelin 1

decreases activity

Dantrolene results in decreased activity of EDN1 protein

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885

G

eukaryotic translation initiation factor 2 alpha kinase 3

decreases phosphorylation

Dantrolene results in decreased phosphorylation of EIF2AK3 protein

NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911

G

eukaryotic translation initiation factor 2 subunit alpha

decreases phosphorylation
multiple interactions

Dantrolene results in decreased phosphorylation of EIF2S1 protein
Dantrolene inhibits the reaction [tributyltin results in increased phosphorylation of EIF2S1 protein]

PMID:15921666 PMID:23743301

NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:97,672,766...97,706,225

G

FKBP prolyl isomerase 1A

multiple interactions

Dantrolene inhibits the reaction [Halothane results in increased expression of FKBP1A mRNA]

NCBI chr 3:160,500,748...160,520,492
Ensembl chr 3:140,040,278...140,060,743

G

FKBP prolyl isomerase 1B

multiple interactions

Dantrolene inhibits the reaction [Halothane results in increased expression of FKBP1B mRNA]

NCBI chr 6:33,551,583...33,570,055
Ensembl chr 6:27,838,802...27,848,653

G

glial fibrillary acidic protein

multiple interactions

Dantrolene inhibits the reaction [diphenylditelluride results in decreased phosphorylation of GFAP protein]; Dantrolene inhibits the reaction [diphenylditelluride results in increased phosphorylation of GFAP protein]

PMID:21863293 PMID:21879721

NCBI chr10:88,352,987...88,361,661
Ensembl chr10:87,852,890...87,861,589

G

glutamic--pyruvic transaminase

multiple interactions

Dantrolene inhibits the reaction [Halothane results in increased expression of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494

G

heme oxygenase 1

multiple interactions

Dantrolene inhibits the reaction [Halothane results in increased expression of HMOX1 mRNA]

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079

G

homer scaffold protein 1

multiple interactions

Dantrolene inhibits the reaction [Halothane results in increased expression of HOMER1 mRNA]

NCBI chr 2:26,279,012...26,388,279
Ensembl chr 2:24,543,093...24,644,785

G

heat shock protein family A (Hsp70) member 5

multiple interactions

Dantrolene inhibits the reaction [tributyltin results in increased expression of HSPA5 protein]

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891

G

interferon gamma

multiple interactions

Dantrolene inhibits the reaction [taurolithocholic acid 3-sulfate results in increased expression of IFNG mRNA]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor 1

decreases response to substance

Dantrolene results in decreased susceptibility to IGF1 protein

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor 2

decreases response to substance

Dantrolene results in decreased susceptibility to IGF2 protein

NCBI chr 1:207,243,873...207,261,263
Ensembl chr 1:197,814,410...197,823,018

G

interleukin 10

multiple interactions
affects expression

Dantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]]
Dantrolene affects the expression of IL10 protein

PMID:17707769 PMID:25051504

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 beta

affects expression
multiple interactions

Dantrolene affects the expression of IL1B mRNA
Dantrolene inhibits the reaction [Halothane results in increased expression of IL1B mRNA]

PMID:25051504 PMID:32795494

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

Dantrolene inhibits the reaction [taurolithocholic acid 3-sulfate results in increased expression of IL6 mRNA]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

potassium voltage-gated channel subfamily H member 2

decreases activity

Dantrolene results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008

G

potassium inwardly-rectifying channel, subfamily J, member 11

multiple interactions

Dantrolene inhibits the reaction [KCNJ11 protein mutant form results in increased abundance of Calcium]

NCBI chr 1:105,727,473...105,731,167
Ensembl chr 1:96,591,049...96,594,082

G

leptin

decreases expression

Dantrolene results in decreased expression of LEP protein

NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262

G

myocyte enhancer factor 2a

multiple interactions

Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2A mRNA]; Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2A protein]

NCBI chr 1:130,258,083...130,392,819
Ensembl chr 1:120,850,080...120,981,948

G

myocyte enhancer factor 2C

multiple interactions

Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2C mRNA]; Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2C protein]

NCBI chr 2:15,708,732...15,871,639
Ensembl chr 2:13,993,438...14,132,880

G

myosin heavy chain 7

multiple interactions

Dantrolene inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]

NCBI chr15:32,416,525...32,439,851
Ensembl chr15:28,446,550...28,468,217

G

neurofilament light chain

multiple interactions

Dantrolene inhibits the reaction [diphenylditelluride results in decreased phosphorylation of NEFL protein]; Dantrolene inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFL protein]

PMID:21863293 PMID:21879721

NCBI chr15:46,477,330...46,481,203
Ensembl chr15:42,301,916...42,305,793

G

neurofilament medium chain

multiple interactions

Dantrolene inhibits the reaction [diphenylditelluride results in decreased phosphorylation of NEFM protein]; Dantrolene inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFM protein]

PMID:21863293 PMID:21879721

NCBI chr15:46,535,857...46,541,161
Ensembl chr15:42,360,454...42,365,755

G

natriuretic peptide A

multiple interactions

Dantrolene inhibits the reaction [Caffeine results in increased expression of NPPA mRNA]

NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:158,429,042...158,430,351

G

natriuretic peptide B

multiple interactions

Dantrolene inhibits the reaction [Caffeine results in increased expression of NPPB mRNA]

NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:158,416,866...158,418,168

G

ryanodine receptor 1

multiple interactions

Dantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]]; Dantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] which results in increased transport of Calcium]

NCBI chr 1:93,420,078...93,551,305
Ensembl chr 1:84,292,578...84,423,812

G

ryanodine receptor 2

multiple interactions

Dantrolene inhibits the reaction [Caffeine promotes the reaction [RYR2 protein results in increased secretion of Calcium]]

NCBI chr17:63,081,527...63,667,141
Ensembl chr17:58,389,925...58,975,142

G

S100 calcium binding protein A8

multiple interactions

Dantrolene inhibits the reaction [Halothane results in increased expression of S100A8 mRNA]

NCBI chr 2:178,464,095...178,465,223
Ensembl chr 2:176,167,124...176,167,643

G

S100 calcium binding protein A9

multiple interactions

Dantrolene inhibits the reaction [Halothane results in increased expression of S100A9 mRNA]

NCBI chr 2:178,487,941...178,490,622
Ensembl chr 2:176,190,361...176,193,230

G

steroidogenic acute regulatory protein

multiple interactions

Dantrolene inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR mRNA]

NCBI chr16:72,969,824...72,974,447
Ensembl chr16:66,264,807...66,271,672

G

tumor necrosis factor

decreases expression
multiple interactions

Dantrolene results in decreased expression of TNF protein
Dantrolene inhibits the reaction [Halothane results in increased expression of TNF mRNA]

PMID:11236903 PMID:32795494

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

vascular cell adhesion molecule 1

multiple interactions

Dantrolene inhibits the reaction [Halothane results in increased expression of VCAM1 mRNA]

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958

G

vimentin

multiple interactions

Dantrolene inhibits the reaction [diphenylditelluride results in decreased phosphorylation of VIM protein]; Dantrolene inhibits the reaction [diphenylditelluride results in increased phosphorylation of VIM protein]

PMID:21863293 PMID:21879721

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187

G

X-box binding protein 1

multiple interactions

Dantrolene inhibits the reaction [perfluorooctanoic acid results in increased expression of XBP1 mRNA alternative form]; Dantrolene inhibits the reaction [Thapsigargin results in increased expression of XBP1 mRNA alternative form]

NCBI chr14:84,604,623...84,609,707
Ensembl chr14:80,390,643...80,395,693

darifenacin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cholinergic receptor, muscarinic 2

multiple interactions

darifenacin binds to and results in decreased activity of CHRM2 protein

NCBI chr 4:65,981,136...66,116,128
Ensembl chr 4:65,014,144...65,149,103

G

cholinergic receptor, muscarinic 3

multiple interactions

darifenacin binds to and results in decreased activity of CHRM3 protein

PMID:11488427 PMID:15140916

NCBI chr17:64,696,549...65,158,622
Ensembl chr17:60,005,202...60,467,278

G

potassium voltage-gated channel subfamily H member 2

decreases activity

darifenacin results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008

decamethonium

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

butyrylcholinesterase

decreases activity

decamethonium results in decreased activity of BCHE protein

NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:158,307,584...158,401,148

G

cholinergic receptor nicotinic alpha 4 subunit

multiple interactions

Carbachol inhibits the reaction [decamethonium binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; decamethonium binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; decamethonium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; decamethonium results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]

NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:168,136,266...168,156,957

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

Carbachol inhibits the reaction [decamethonium binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; decamethonium binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; decamethonium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; decamethonium results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]

NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:175,181,402...175,189,619

dicyclomine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 22 member 2

multiple interactions

Dicyclomine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268

dihydro-beta-erythroidine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein]

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

atonal bHLH transcription factor 1

multiple interactions

Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased expression of ATOH1 mRNA]

NCBI chr 4:95,241,933...95,244,028
Ensembl chr 4:93,912,068...93,914,154

G

cyclin D1

multiple interactions

Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of CCND1 mRNA]

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602

G

cyclin-dependent kinase 4

multiple interactions

Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of CDK4 protein]

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403

G

cholinergic receptor nicotinic alpha 2 subunit

multiple interactions

dihydro-beta-erythroidine affects binding to Chrna2 protein; dihydro-beta-erythroidine inhibits the reaction [epibatidine affects binding to Chrna2 protein] in rat retina

RGD

NCBI chr15:44,517,862...44,534,144
Ensembl chr15:40,342,317...40,358,601

G

cholinergic receptor nicotinic alpha 3 subunit

multiple interactions

Dihydro-beta-Erythroidine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]
dihydro-beta-erythroidine affects binding [Epibatidine binds to Chrna3 protein]

CTD
RGD

PMID:9687574 PMID:16129735 PMID:15016836

RGD:2303195, RGD:2303194

NCBI chr 8:64,297,755...64,311,251
Ensembl chr 8:55,401,702...55,415,165

G

cholinergic receptor nicotinic alpha 4 subunit

multiple interactions
affects binding

Carbachol inhibits the reaction [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine inhibits the reaction [1-Butanol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
dihydro-beta-erythroidine affects binding to Chrna4 protein; dihydro-beta-erythroidine inhibits the reaction [epibatidine affects binding to Chrna4 protein] in rat retina
dihydro-beta-erythroidine affects binding to Chrna4 protein; dihydro-beta-erythroidine competes with [Epibatidine binds to Chrna4 protein]
[Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in decreased susceptibility to Nicotine; Dihydro-beta-Erythroidine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in increased expression of CHRNA4 mRNA]; Dihydro-beta-Erythroidine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; Dihydro-beta-Erythroidine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine inhibits the reaction [3-(2-(pyrrolidinyl)methoxy)pyridine analog results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
[CHRNA4 protein binds to CHRNB4 protein] which binds to Dihydro-beta-Erythroidine

CTD
RGD

PMID:9687574 PMID:10945867 PMID:11600638 PMID:12604691 PMID:14645658 More...

RGD:2303195, RGD:2303194

NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:168,136,266...168,156,957

G

cholinergic receptor nicotinic alpha 7 subunit

increases activity
multiple interactions
affects response to substance

Dihydro-beta-Erythroidine results in increased activity of CHRNA7 protein mutant form
Dihydro-beta-Erythroidine affects the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]
CHRNA7 protein mutant form affects the susceptibility to Dihydro-beta-Erythroidine
Dihydro-beta-Erythroidine binds to and results in decreased activity of CHRNA7 protein

PMID:10082212 PMID:19448648

NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

Carbachol inhibits the reaction [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine inhibits the reaction [1-Butanol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine inhibits the reaction [[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in decreased uptake of Calcium]; Dihydro-beta-Erythroidine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
dihydro-beta-erythroidine affects binding to Chrnb2 protein; dihydro-beta-erythroidine inhibits the reaction [epibatidine affects binding to Chrnb2 protein] in rat retina
dihydro-beta-erythroidine affects binding to Chrnb2 protein; dihydro-beta-erythroidine competes with [Epibatidine binds to Chrnb2 protein]
Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine inhibits the reaction [3-(2-(pyrrolidinyl)methoxy)pyridine analog results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
[Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in decreased susceptibility to Nicotine; Dihydro-beta-Erythroidine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; Dihydro-beta-Erythroidine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]

CTD
RGD

PMID:10945867 PMID:11600638 PMID:12604691 PMID:14645658 PMID:16569710 More...

RGD:2303195, RGD:2303194

NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:175,181,402...175,189,619

G

cholinergic receptor nicotinic beta 3 subunit

multiple interactions

dihydro-beta-erythroidine affects binding to Chrnb3 protein; dihydro-beta-erythroidine inhibits the reaction [epibatidine affects binding to Chrnb3 protein] in rat retina

RGD

NCBI chr16:71,411,847...71,454,225
Ensembl chr16:64,714,169...64,751,360

G

cholinergic receptor nicotinic beta 4 subunit

affects binding
multiple interactions

[CHRNA4 protein binds to CHRNB4 protein] which binds to Dihydro-beta-Erythroidine
Dihydro-beta-Erythroidine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]

NCBI chr 8:64,312,644...64,333,319
Ensembl chr 8:55,418,313...55,437,027

G

C-X-C motif chemokine receptor 4

multiple interactions

[Mecamylamine co-treated with Dihydro-beta-Erythroidine co-treated with Bungarotoxins] inhibits the reaction [Nicotine results in increased expression of CXCR4 protein]

NCBI chr13:42,630,383...42,634,288
Ensembl chr13:40,077,976...40,081,883

G

DNA methyltransferase 1

multiple interactions

Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in decreased expression of DNMT1 mRNA]

NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:19,440,611...19,486,659

G

glutamate decarboxylase 1

multiple interactions

Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in increased expression of GAD1 mRNA]

NCBI chr 3:75,777,260...75,818,099
Ensembl chr 3:55,369,704...55,410,333

G

solute carrier family 6 member 3

multiple interactions

Dihydro-beta-Erythroidine affects the reaction [Nicotine results in decreased activity of SLC6A3 protein]

NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:29,709,443...29,750,413

G

TNF receptor superfamily member 11B

multiple interactions

Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased expression of TNFRSF11B mRNA]

NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:85,566,520...85,594,538

G

TNF superfamily member 11

multiple interactions

Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of TNFSF11 mRNA]

NCBI chr15:60,083,008...60,114,479
Ensembl chr15:53,673,877...53,705,445

glycycoumarin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

peroxisome proliferator-activated receptor gamma

affects binding

glycycoumarin binds to PPARG protein

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468

midazolam

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases activity
multiple interactions

Midazolam results in decreased activity of ABCB11 protein
Midazolam inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]

PMID:20829430 PMID:24014644

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 1A

increases expression

Midazolam results in increased expression of ABCB1 protein

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily B member 6

multiple interactions
decreases metabolic processing

[ABCB6 gene mutant form results in decreased expression of CYP3A11 mRNA] inhibits the reaction [CYP3A11 protein results in increased metabolism of Midazolam]; [ABCB6 gene mutant form results in decreased expression of CYP3A11 protein] inhibits the reaction [CYP3A11 protein results in increased metabolism of Midazolam]
ABCB6 gene mutant form results in decreased metabolism of Midazolam

NCBI chr 9:84,117,222...84,125,939
Ensembl chr 9:76,668,554...76,676,924

G

allograft inflammatory factor 1

multiple interactions

[Midazolam co-treated with Lipopolysaccharides] affects the expression of AIF1 protein; jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of AIF1 protein]; NFIL3 protein affects the reaction [jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of AIF1 protein]]

NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,646,777...3,652,668

G

BCL2, apoptosis regulator

increases expression

Midazolam results in increased expression of BCL2

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

C-C motif chemokine ligand 2

multiple interactions

[Midazolam co-treated with Lipopolysaccharides] affects the expression of CCL2 mRNA; jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of CCL2 mRNA]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 5

multiple interactions

[Midazolam co-treated with Lipopolysaccharides] affects the expression of CCL5 mRNA; jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of CCL5 mRNA]

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377

G

colony stimulating factor 1 receptor

multiple interactions

[Midazolam co-treated with Lipopolysaccharides] affects the expression of CSF1R mRNA; jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of CSF1R mRNA]; NFIL3 protein affects the reaction [jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of CSF1R mRNA]]

NCBI chr18:56,834,152...56,860,804
Ensembl chr18:54,546,659...54,590,415

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity

Midazolam results in decreased activity of CYP1A1 protein

PMID:18420780 PMID:33814510

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

Midazolam results in decreased activity of CYP1B1 protein

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily a, polypeptide 3

decreases activity

Midazolam results in decreased activity of CYP2A4 protein

NCBI chr 1:91,299,584...91,307,650
Ensembl chr 1:82,169,949...82,179,979

G

cytochrome P450, family 2, subfamily b, polypeptide 3

decreases activity

Midazolam results in decreased activity of CYP2B10 protein

NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases activity

Midazolam results in decreased activity of CYP2C29 protein

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily d, polypeptide 4

decreases activity

Midazolam results in decreased activity of CYP2D6 protein

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases metabolic processing

CYP2E1 protein results in increased metabolism of Midazolam

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases hydroxylation
increases glucuronidation
affects metabolic processing
decreases abundance
increases metabolic processing
increases expression
increases oxidation
multiple interactions

CYP3A2 protein results in increased hydroxylation of Midazolam
CYP3A4 protein results in increased glucuronidation of Midazolam
CYP3A4 gene polymorphism affects the metabolism of Midazolam; CYP3A4 protein affects the metabolism of Midazolam
CYP3A4 protein results in decreased abundance of Midazolam
CYP3A4 protein results in increased metabolism of Midazolam
CYP3A4 protein results in increased hydroxylation of Midazolam
Midazolam results in increased expression of CYP3A4 mRNA
CYP3A4 protein results in increased oxidation of Midazolam
[3-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [5-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [6-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [6-methylflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [7-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [[3-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[5-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[6-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[6-methylflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[7-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[alpha-naphthoflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[artemetin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[beta-Naphthoflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[chrysin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[eupatilin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[flavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[galangin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[nobiletin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[sinensetin analog results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[sinensetin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[tangeretin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [alpha-naphthoflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [artemetin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [beta-Naphthoflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [Carbamazepine results in increased expression of CYP3A4 protein] which results in decreased abundance of Midazolam; [chrysin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased abundance of 1-hydroxymethylmidazolam; [CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased abundance of 4-hydroxymidazolam; [CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam; [Dexamethasone results in increased expression of CYP3A4 protein] which results in decreased abundance of Midazolam; [eupatilin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [flavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [galangin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased hydroxylation of Midazolam; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Midazolam; [L 754394 results in decreased activity of CYP3A4 protein] which results in decreased hydroxylation of Midazolam; [nobiletin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [Pioglitazone results in increased expression of CYP3A4 protein] which results in decreased abundance of Midazolam; [Rifampin results in increased expression of CYP3A4 protein] which results in decreased abundance of Midazolam; [sinensetin analog results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [sinensetin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [tangeretin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; acacetin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; acacetin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; allyl methyl disulfide inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Amiodarone inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Apigenin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; Apigenin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Atorvastatin inhibits the reaction [CYP3A4 protein affects the metabolism of Midazolam]; bufalin promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; bufogenin promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; caryophyllene inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; cinobufagin promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; citral inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Curcumin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; CYP3A4 protein inhibits the reaction [Rifampin results in decreased hydroxylation of Midazolam]; deoxyelephantopin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Diltiazem inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; erdafitinib inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; erdafitinib inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Eucalyptol inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; flavanone inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; flavanone promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; flavone inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; flavone promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Fluvastatin inhibits the reaction [CYP3A4 protein affects the metabolism of Midazolam]; fructus schizandrae, radix ginseng, radix ophiopogonis drug combination affects the reaction [CYP3A4 protein affects the metabolism of Midazolam]; Fusidic Acid inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; galangin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; galangin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; gingerol inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased abundance of Midazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; Limonene inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Midazolam inhibits the reaction [CYP3A4 protein results in decreased methylation of Etoposide]; Midazolam inhibits the reaction [CYP3A4 protein results in decreased methylation of Teniposide]; Midazolam inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; Mifepristone inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Mifepristone inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; muscone promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; NADP deficiency inhibits the reaction [erdafitinib inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]]; NADP deficiency inhibits the reaction [erdafitinib inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]]; Oleanolic Acid inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; Pantoprazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; potassium ferricyanide inhibits the reaction [Diltiazem inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]]; potassium ferricyanide promotes the reaction [Diltiazem inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]]; rabeprazole-thioether inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Rifampin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Rifampin promotes the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; shexiang baoxin promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; Verapamil inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; YM 758 inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; zafirlukast inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam]
shikonin inhibits the reaction [CYP3A2 protein results in increased hydroxylation of Midazolam]

PMID:8114683 PMID:10997946 PMID:11911841 PMID:12401345 PMID:12433797 More...

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

increases hydroxylation

CYP3A23-3A1 protein results in increased hydroxylation of Midazolam

NCBI chr12:14,369,950...14,398,803
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

cytochrome P450, family 3, subfamily a, polypeptide 9

affects metabolic processing
increases metabolic processing
multiple interactions
increases hydroxylation

CYP3A5 gene polymorphism affects the metabolism of Midazolam; CYP3A5 protein affects the metabolism of Midazolam
CYP3A5 protein results in increased metabolism of Midazolam
[CYP3A5 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; erdafitinib inhibits the reaction [[CYP3A5 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; erdafitinib inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Midazolam]; fructus schizandrae, radix ginseng, radix ophiopogonis drug combination affects the reaction [CYP3A5 protein affects the metabolism of Midazolam]

PMID:15383492 PMID:15499178 PMID:15801540 PMID:15900284 PMID:19557931 More...

NCBI chr12:21,919,955...21,960,160
Ensembl chr12:16,806,207...16,846,422

G

gamma-aminobutyric acid type A receptor subunit alpha 4

increases expression

Midazolam results in increased expression of GABRA4 mRNA

NCBI chr14:36,944,747...37,021,652
Ensembl chr14:36,590,782...36,665,844

G

gamma-aminobutyric acid type A receptor subunit alpha6

decreases response to substance

GABRA6 protein mutant form results in decreased susceptibility to Midazolam

NCBI chr10:27,311,965...27,327,337
Ensembl chr10:26,810,423...26,825,769

G

gamma-aminobutyric acid type A receptor subunit beta 3

increases response to substance

GABRB3 protein results in increased susceptibility to Midazolam

NCBI chr 1:117,602,772...117,838,230
Ensembl chr 1:108,296,124...108,698,961

G

gamma-aminobutyric acid type A receptor subunit epsilon

decreases response to substance

GABRE protein results in decreased susceptibility to Midazolam

NCBI chr X:155,102,078...155,120,821
Ensembl chr X:150,060,040...150,078,693

G

gamma-aminobutyric acid type A receptor subunit gamma 2

affects response to substance
affects binding

GABRG2 protein alternative form affects the susceptibility to Midazolam
GABRG2 protein mutant form binds to Midazolam

NCBI chr10:26,876,926...26,965,523
Ensembl chr10:26,374,694...26,464,346

G

gastrin

multiple interactions

[fluanisone co-treated with Fentanyl co-treated with Midazolam] inhibits the reaction [GAST protein results in increased secretion of Histamine]

NCBI chr10:85,765,216...85,767,881
Ensembl chr10:85,264,832...85,267,496

G

glutamate ionotropic receptor NMDA type subunit 2A

affects response to substance

GRIN2A protein affects the susceptibility to Midazolam

NCBI chr10:6,136,458...6,560,003
Ensembl chr10:5,631,369...6,044,637

G

interleukin 1 beta

multiple interactions

[Midazolam co-treated with Lipopolysaccharides] affects the expression of IL1B mRNA; jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of IL1B mRNA]; NFIL3 protein affects the reaction [jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of IL1B mRNA]]; NFIL3 protein affects the reaction [jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of IL1B protein]]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

[Midazolam co-treated with Lipopolysaccharides] affects the expression of IL6 mRNA; jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of IL6 mRNA]; NFIL3 protein affects the reaction [jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of IL6 mRNA]]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 6 receptor

multiple interactions

[Midazolam co-treated with Lipopolysaccharides] affects the expression of IL6RA mRNA; jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of IL6RA mRNA]; NFIL3 protein affects the reaction [jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of IL6RA mRNA]]

NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:175,298,686...175,347,536

G

integrin subunit alpha M

multiple interactions

[Midazolam cotreated with N-formyl-methionyl-leucyl-phenylalanine] decreases expression of ITGAM protein on neutrophils

RGD

NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:182,659,000...182,709,503

G

mitogen activated protein kinase 1

multiple interactions

[Midazolam co-treated with Lipopolysaccharides] affects the expression of MAPK1 mRNA; [Midazolam co-treated with Lipopolysaccharides] affects the phosphorylation of and affects the expression of MAPK1 protein; jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of MAPK1 mRNA]; jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the phosphorylation of and affects the expression of MAPK1 protein]; NFIL3 protein affects the reaction [jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of MAPK1 mRNA]]; NFIL3 protein affects the reaction [jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the phosphorylation of and affects the expression of MAPK1 protein]]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

[Midazolam co-treated with Lipopolysaccharides] affects the expression of MAPK3 mRNA; [Midazolam co-treated with Lipopolysaccharides] affects the phosphorylation of and affects the expression of MAPK3 protein; jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of MAPK3 mRNA]; jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the phosphorylation of and affects the expression of MAPK3 protein]; NFIL3 protein affects the reaction [jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of MAPK3 mRNA]]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

nuclear factor, interleukin 3 regulated

multiple interactions

[Midazolam co-treated with Lipopolysaccharides] affects the expression of NFIL3 mRNA; [Midazolam co-treated with Lipopolysaccharides] affects the expression of NFIL3 protein; jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of NFIL3 mRNA]; jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of NFIL3 protein]; NFIL3 protein affects the reaction [jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of AIF1 protein]]; NFIL3 protein affects the reaction [jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of CSF1R mRNA]]; NFIL3 protein affects the reaction [jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of IL1B mRNA]]; NFIL3 protein affects the reaction [jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of IL1B protein]]; NFIL3 protein affects the reaction [jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of IL6 mRNA]]; NFIL3 protein affects the reaction [jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of IL6RA mRNA]]; NFIL3 protein affects the reaction [jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of MAPK1 mRNA]]; NFIL3 protein affects the reaction [jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of MAPK3 mRNA]]; NFIL3 protein affects the reaction [jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of TNF protein]]; NFIL3 protein affects the reaction [jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of TREM2 mRNA]]; NFIL3 protein affects the reaction [jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of TYROBP mRNA]]; NFIL3 protein affects the reaction [jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the phosphorylation of and affects the expression of MAPK1 protein]]; NFIL3 protein affects the reaction [jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the phosphorylation of RELA protein]]

NCBI chr17:12,432,376...12,447,605
Ensembl chr17:12,280,484...12,295,858

G

nuclear receptor subfamily 1, group I, member 2

increases activity
multiple interactions

Midazolam results in increased activity of NR1I2 protein
NR1I2 gene promotes the reaction [Rifampin results in increased metabolism of Midazolam]

PMID:18799805 PMID:20080160

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 1, group I, member 3

decreases metabolic processing

NR1I3 gene mutant form results in decreased metabolism of Midazolam

NCBI chr13:86,165,327...86,170,362
Ensembl chr13:83,632,899...83,637,906

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

[Midazolam co-treated with Lipopolysaccharides] affects the expression of and affects the phosphorylation of RELA protein; jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the phosphorylation of and affects the expression of RELA protein]; NFIL3 protein affects the reaction [jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the phosphorylation of RELA protein]]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484

G

steroidogenic acute regulatory protein

increases expression

Midazolam results in increased expression of STAR protein

NCBI chr16:72,969,824...72,974,447
Ensembl chr16:66,264,807...66,271,672

G

synapsin I

decreases expression

Midazolam results in decreased expression of SYN1 protein

NCBI chr X:3,725,745...3,780,940
Ensembl chr X:1,172,208...1,227,396

G

tumor necrosis factor

multiple interactions

[Midazolam co-treated with Lipopolysaccharides] affects the expression of TNF protein; jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of TNF protein]; NFIL3 protein affects the reaction [jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of TNF protein]]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

triggering receptor expressed on myeloid cells 2

multiple interactions

[Midazolam co-treated with Lipopolysaccharides] affects the expression of TREM2 mRNA; jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of TREM2 mRNA]; NFIL3 protein affects the reaction [jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of TREM2 mRNA]]

NCBI chr 9:20,145,215...20,151,797
Ensembl chr 9:12,647,259...12,654,170

G

thyrotropin releasing hormone

multiple interactions

Midazolam inhibits the reaction [TRH protein modified form binds to TRHR protein]

NCBI chr 4:126,299,236...126,301,762
Ensembl chr 4:124,742,111...124,744,637

G

thyrotropin releasing hormone receptor

multiple interactions

Midazolam inhibits the reaction [TRH protein modified form binds to TRHR protein]

NCBI chr 7:77,233,175...77,277,988
Ensembl chr 7:75,348,672...75,393,309

G

translocator protein

increases expression
multiple interactions
affects binding

Midazolam results in increased expression of TSPO protein
[Ketamine co-treated with Midazolam co-treated with Valproic Acid] inhibits the reaction [[Sarin co-treated with [Atropine co-treated with trimethylene-bis(4-hydroxyiminomethylpyridinium)]] results in increased expression of TSPO protein]
Midazolam binds to TSPO protein

PMID:7603229 PMID:19857560 PMID:33823148

NCBI chr 7:116,600,214...116,610,461
Ensembl chr 7:114,720,188...114,730,450

G

transmembrane immune signaling adaptor Tyrobp

multiple interactions

[Midazolam co-treated with Lipopolysaccharides] affects the expression of TYROBP mRNA; jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of TYROBP mRNA]; NFIL3 protein affects the reaction [jujuboside A affects the reaction [[Midazolam co-treated with Lipopolysaccharides] affects the expression of TYROBP mRNA]]

NCBI chr 1:94,800,372...94,804,307
Ensembl chr 1:85,672,994...85,676,848

nimetazepam

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

multiple interactions

CYP3A4 protein affects the reaction [nimetazepam results in increased activity of CASP3 protein]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

multiple interactions

CYP3A4 protein affects the reaction [nimetazepam results in increased activity of CASP7 protein]

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

CYP3A4 protein affects the reaction [nimetazepam results in increased activity of CASP3 protein]; CYP3A4 protein affects the reaction [nimetazepam results in increased activity of CASP7 protein]; CYP3A4 protein results in increased metabolism of and results in increased activity of nimetazepam

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008

G

solute carrier family 22 member 2

multiple interactions

nimetazepam inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268

nitrazepam

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldo-keto reductase family 1, member C1

decreases activity

Nitrazepam results in decreased activity of AKR1C1 protein

NCBI chr17:70,720,397...70,747,285
Ensembl chr17:65,810,475...65,837,326

G

aldo-keto reductase family 1, member C2

decreases activity

Nitrazepam results in decreased activity of AKR1C2 protein

NCBI chr17:70,669,684...70,717,935
Ensembl chr17:65,759,788...65,775,764

G

aldo-keto reductase family 1, member C3

decreases activity

Nitrazepam results in decreased activity of AKR1C3 protein

NCBI chr17:71,020,884...71,037,779
Ensembl chr17:66,110,963...66,127,873

G

caspase 3

multiple interactions

CYP3A4 protein affects the reaction [Nitrazepam results in increased activity of CASP3 protein]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

multiple interactions

CYP3A4 protein affects the reaction [Nitrazepam results in increased activity of CASP7 protein]

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

CYP3A4 protein affects the reaction [Nitrazepam results in increased activity of CASP3 protein]; CYP3A4 protein affects the reaction [Nitrazepam results in increased activity of CASP7 protein]; CYP3A4 protein results in increased metabolism of and results in increased activity of Nitrazepam

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008

G

estrogen receptor 1

multiple interactions

Nitrazepam binds to and results in increased activity of ESR1 protein

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002

nitroglycerin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetyl-CoA acetyltransferase 1

increases expression

Nitroglycerin results in increased expression of ACAT1 mRNA

NCBI chr 8:62,876,003...62,905,080
Ensembl chr 8:53,979,813...54,008,855

G

actin, beta

decreases expression

Nitroglycerin results in decreased expression of ACTB mRNA

NCBI chr12:16,776,664...16,779,634
Ensembl chr12:11,663,109...11,672,877

G

aldehyde dehydrogenase 1 family, member A1

decreases expression

Nitroglycerin results in decreased expression of ALDH1A1 mRNA

NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 2 family member

multiple interactions
decreases activity
increases response to substance
decreases expression
affects metabolic processing
affects response to substance

[1-aminocyclopropanol analog results in decreased activity of ALDH2 protein] which results in decreased metabolism of Nitroglycerin; [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in decreased metabolism of Nitroglycerin; [Cyanamide results in decreased activity of ALDH2 protein] which results in decreased metabolism of Nitroglycerin; Acetylcysteine inhibits the reaction [Nitroglycerin results in decreased activity of ALDH2 protein]; ALDH2 protein affects the reaction [Nitroglycerin results in decreased abundance of Cyclic GMP]
ALDH2 protein affects the reaction [Ascorbic Acid deficiency results in decreased susceptibility to Nitroglycerin]
ALDH2 protein results in increased susceptibility to Nitroglycerin
Nitroglycerin results in decreased expression of ALDH2 mRNA; Nitroglycerin results in decreased expression of ALDH2 protein
ALDH2 protein affects the metabolism of and results in increased activity of Nitroglycerin; ALDH2 protein affects the reaction [Nitroglycerin results in increased abundance of Reactive Oxygen Species]; Hemin inhibits the reaction [Nitroglycerin results in decreased activity of ALDH2 protein]
ALDH2 protein affects the metabolism of Nitroglycerin
ALDH2 gene polymorphism affects the susceptibility to Nitroglycerin; ALDH2 protein affects the susceptibility to Nitroglycerin; ALDH2 protein polymorphism affects the susceptibility to Nitroglycerin

PMID:15331769 PMID:16440063 PMID:17092343 PMID:17493633 PMID:17541025 More...

NCBI chr12:40,610,244...40,643,220
Ensembl chr12:34,901,219...34,982,521

G

arachidonate 15-lipoxygenase

decreases expression

Nitroglycerin results in decreased expression of ALOX15 mRNA

NCBI chr10:55,559,060...55,567,535
Ensembl chr10:55,060,412...55,068,874

G

adaptor related protein complex 2 subunit mu 1

increases expression

Nitroglycerin results in increased expression of AP2M1 mRNA

NCBI chr11:93,859,690...93,868,600
Ensembl chr11:80,328,041...80,364,140

G

apurinic/apyrimidinic endodeoxyribonuclease 1

increases expression

Nitroglycerin results in increased expression of APEX1 mRNA

NCBI chr15:26,618,146...26,620,330
Ensembl chr15:24,144,362...24,146,785

G

apolipoprotein A1

decreases expression

Nitroglycerin results in decreased expression of APOA1 mRNA

NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:46,527,144...46,529,035

G

ARF like GTPase 2

increases expression

Nitroglycerin results in increased expression of ARL2 mRNA

NCBI chr 1:212,863,422...212,875,425
Ensembl chr 1:203,434,129...203,446,119

G

ATP synthase F1 subunit alpha

decreases expression

Nitroglycerin results in decreased expression of ATP5F1A mRNA

NCBI chr18:73,567,537...73,575,473
Ensembl chr18:71,292,374...71,300,794

G

beta-2 microglobulin

affects expression

Nitroglycerin affects the expression of B2M protein

NCBI chr 3:129,549,236...129,555,354
Ensembl chr 3:109,095,729...109,101,766

G

branched chain keto acid dehydrogenase E1 subunit beta

decreases expression

Nitroglycerin results in decreased expression of BCKDHB mRNA

NCBI chr 8:93,725,277...93,907,799
Ensembl chr 8:84,845,264...85,027,812

G

BCL2, apoptosis regulator

decreases expression

Nitroglycerin results in decreased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

complement C3

increases expression

Nitroglycerin results in increased expression of C3 protein alternative form

NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,087,437...2,114,429

G

calcitonin-related polypeptide alpha

multiple interactions
increases expression
affects expression

Capsaicin inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA]; Dexamethasone inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA]; Ergotamine inhibits the reaction [Nitroglycerin results in increased expression of CALCA protein]; Methylene Blue inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA]; NOS2 protein affects the reaction [Nitroglycerin results in increased expression of CALCA mRNA]; pimagedine inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA]; Plant Oils inhibits the reaction [Nitroglycerin results in increased expression of CALCA protein]; yufengningxin inhibits the reaction [Nitroglycerin results in increased expression of CALCA protein]
Nitroglycerin results in increased expression of CALCA mRNA; Nitroglycerin results in increased expression of CALCA protein
Nitroglycerin affects the expression of CALCA protein

PMID:11919648 PMID:14659530 PMID:14729435 PMID:19121572 PMID:32147481 More...

NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:168,878,214...168,883,105

G

calmodulin 2

increases expression

Nitroglycerin results in increased expression of CALM2 mRNA

NCBI chr 6:12,845,170...12,857,830
Ensembl chr 6:7,091,567...7,104,287
Ensembl chr15:7,091,567...7,104,287

G

calpain 2

decreases expression

Nitroglycerin results in decreased expression of CAPN2 mRNA

NCBI chr13:96,681,902...96,732,625
Ensembl chr13:94,150,240...94,200,969

G

caspase 1

multiple interactions

Nitroglycerin results in increased cleavage of and results in increased activity of CASP1 protein

NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

decreases expression
multiple interactions

Nitroglycerin results in decreased expression of CASP3 protein modified form
Nitroglycerin results in increased cleavage of and results in increased activity of CASP3 protein

PMID:12105852 PMID:17322376

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions

Nitroglycerin results in increased expression of and results in increased activity of CAT protein

PMID:12860443 PMID:14732477

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478

G

CD3 delta subunit of T-cell receptor complex

increases expression

Nitroglycerin results in increased expression of CD3D mRNA

NCBI chr 8:54,184,573...54,190,112
Ensembl chr 8:45,288,749...45,301,809

G

Cd5 molecule

decreases expression

Nitroglycerin results in decreased expression of CD5 mRNA

NCBI chr 1:216,790,245...216,811,209
Ensembl chr 1:207,365,337...207,386,313

G

Cd53 molecule

decreases expression

Nitroglycerin results in decreased expression of CD53 mRNA

NCBI chr 2:197,040,369...197,087,925
Ensembl chr 2:194,352,139...194,399,657

G

cell division cycle 37, HSP90 cochaperone

increases expression

Nitroglycerin results in increased expression of CDC37 mRNA

NCBI chr 8:27,954,292...27,966,935
Ensembl chr 8:19,671,938...19,690,809

G

cyclin-dependent kinase inhibitor 1B

increases expression

Nitroglycerin results in increased expression of CDKN1B mRNA

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982

G

CUGBP, Elav-like family member 2

increases expression

Nitroglycerin results in increased expression of CELF2 mRNA

NCBI chr17:75,813,928...76,639,300
Ensembl chr17:71,210,853...71,728,333

G

creatine kinase B

decreases expression

Nitroglycerin results in decreased expression of CKB mRNA

NCBI chr 6:136,550,583...136,553,464
Ensembl chr 6:130,729,423...130,732,315

G

clusterin

decreases expression

Nitroglycerin results in decreased expression of CLU mRNA

NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315

G

cannabinoid receptor 1

multiple interactions

Nitroglycerin affects the reaction [glyceryl 2-arachidonate affects the activity of CNR1 protein]

NCBI chr 5:53,204,867...53,230,396
Ensembl chr 5:48,408,574...48,435,099

G

ceruloplasmin

decreases expression

Nitroglycerin results in decreased expression of CP mRNA

NCBI chr 2:104,368,336...104,427,119
Ensembl chr 2:102,439,624...102,498,075

G

cysteine-rich protein 2

decreases expression

Nitroglycerin results in decreased expression of CRIP2 mRNA

NCBI chr 6:138,042,175...138,047,121
Ensembl chr 6:132,221,082...132,226,065

G

catenin beta 1

multiple interactions
decreases localization

4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [Nitroglycerin results in decreased localization of CTNNB1 protein]; 4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [Nitroglycerin results in increased degradation of and results in decreased activity of CTNNB1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Nitroglycerin results in increased degradation of CTNNB1 protein]; Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]; Nitroglycerin results in decreased phosphorylation of and results in increased nitrosation of and results in increased degradation of and results in decreased activity of CTNNB1 protein; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin results in decreased localization of CTNNB1 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin results in increased degradation of and results in decreased activity of CTNNB1 protein]

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin D

decreases expression

Nitroglycerin results in decreased expression of CTSD mRNA

NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:197,527,467...197,539,488

G

cytochrome b-245 beta chain

multiple interactions
decreases expression
increases expression
decreases response to substance

CYBB gene mutant form inhibits the reaction [Nitroglycerin results in decreased susceptibility to Acetylcholine]; Rosuvastatin Calcium inhibits the reaction [Nitroglycerin results in increased expression of CYBB mRNA]
Nitroglycerin results in decreased expression of CYBB mRNA
CYBB gene mutant form results in decreased susceptibility to Nitroglycerin

PMID:16633368 PMID:17493633 PMID:18522491

NCBI chr X:16,030,596...16,065,065
Ensembl chr X:13,359,430...13,392,586

G

cytochrome P450, family 11, subfamily b, polypeptide 3

decreases expression

Nitroglycerin results in decreased expression of CYP11B2 mRNA

NCBI chr 7:108,689,319...108,694,808
Ensembl chr 7:106,808,559...106,814,048

G

cytochrome P450, family 1, subfamily a, polypeptide 2

affects expression
decreases expression

Vitamin E inhibits the reaction [nitroglycerine decreases Cyp1a2 protein expression in rat heart]
nitroglycerin decreased expression of Cyp1a2 protein in thoracic aorta of rats

RGD

PMID:16520233 PMID:12688525

RGD:401900296, RGD:401900656

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily b, polypeptide 15

decreases expression

Nitroglycerin results in decreased expression of CYP2B15 mRNA

NCBI chr 1:82,094,188...82,106,492
Ensembl chr 1:82,094,180...82,106,492

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases expression

Nitroglycerin results in increased expression of CYP2E1 mRNA

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023

G

7-dehydrocholesterol reductase

decreases expression

Nitroglycerin results in decreased expression of DHCR7 mRNA

NCBI chr 1:208,444,434...208,460,408
Ensembl chr 1:199,015,081...199,031,055

G

dynein cytoplasmic 1 intermediate chain 1

decreases expression

Nitroglycerin results in decreased expression of DYNC1I1 mRNA

NCBI chr 4:34,819,313...35,132,647
Ensembl chr 4:33,852,927...34,166,149

G

dual specificity tyrosine phosphorylation regulated kinase 1A

decreases expression

Nitroglycerin results in decreased expression of DYRK1A mRNA

NCBI chr11:47,360,824...47,479,033
Ensembl chr11:33,890,490...34,009,420

G

endothelin 1

decreases expression
increases expression
multiple interactions

Nitroglycerin results in decreased expression of EDN1 mRNA
Nitroglycerin results in increased expression of EDN1 protein
Nitroglycerin results in decreased expression of EDN1 mRNA; Nitroglycerin results in decreased expression of EDN1 protein
Losartan inhibits the reaction [Nitroglycerin results in increased expression of EDN1 protein]

PMID:11751199 PMID:12206003 PMID:12901495

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885

G

elastase, neutrophil expressed

increases expression

Nitroglycerin results in increased expression of ELANE protein

NCBI chr 7:10,467,877...10,469,725
Ensembl chr 7:9,817,252...9,819,100

G

elastin

increases expression

Nitroglycerin results in increased expression of ELN mRNA

NCBI chr12:27,604,983...27,648,413
Ensembl chr12:21,968,544...22,011,928

G

fatty acid amide hydrolase

increases activity
multiple interactions

Nitroglycerin results in increased activity of FAAH protein
Nitroglycerin promotes the reaction [FAAH protein results in increased chemical synthesis of Arachidonic Acid]; Nitroglycerin promotes the reaction [FAAH protein results in increased degradation of anandamide]

NCBI chr 5:134,716,545...134,735,396
Ensembl chr 5:129,479,824...129,498,677

G

Fas cell surface death receptor

multiple interactions

Nitroglycerin results in increased expression of and results in increased localization of FAS protein

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591

G

fibroblast growth factor receptor 2

increases expression

Nitroglycerin results in increased expression of FGFR2 mRNA

NCBI chr 1:194,175,703...194,280,914
Ensembl chr 1:184,745,420...184,850,626

G

flavin containing dimethylaniline monoxygenase 1

decreases expression

Nitroglycerin results in decreased expression of FMO1 mRNA

NCBI chr13:77,715,405...77,747,666
Ensembl chr13:75,182,176...75,214,647

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

Nitroglycerin results in increased expression of FOS protein
Nitroglycerin results in increased expression of FOS mRNA; Nitroglycerin results in increased expression of FOS protein
anandamide inhibits the reaction [Nitroglycerin results in increased expression of FOS protein]; Ergotamine inhibits the reaction [Nitroglycerin results in increased expression of FOS protein]; evodiamine inhibits the reaction [Nitroglycerin results in increased expression of FOS mRNA]; Plant Oils inhibits the reaction [Nitroglycerin results in increased expression of FOS protein]; Pregabalin inhibits the reaction [Nitroglycerin results in increased expression of FOS protein]; rizatriptan inhibits the reaction [Nitroglycerin results in increased expression of FOS mRNA]; yufengningxin inhibits the reaction [Nitroglycerin results in increased expression of FOS mRNA]

PMID:7552308 PMID:10426492 PMID:16897600 PMID:18761334 PMID:19121572 More...

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036

G

GTP cyclohydrolase I feedback regulator

decreases expression

Nitroglycerin results in decreased expression of GCHFR mRNA

NCBI chr 3:126,611,892...126,615,926
Ensembl chr 3:106,159,394...106,162,080

G

G protein subunit beta 3

affects response to substance

GNB3 protein affects the susceptibility to Nitroglycerin

NCBI chr 4:159,325,741...159,331,443
Ensembl chr 4:157,639,469...157,645,173

G

G protein subunit gamma 7

decreases expression

Nitroglycerin results in decreased expression of GNG7 mRNA

NCBI chr 7:9,348,148...9,411,924
Ensembl chr 7:8,697,521...8,761,240

G

glutamic--pyruvic transaminase

multiple interactions

Nitroglycerin inhibits the reaction [cupric nitrilotriacetate results in increased activity of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 1

decreases response to substance

GPX1 gene mutant form results in decreased susceptibility to Nitroglycerin

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024

G

glutamate ionotropic receptor AMPA type subunit 1

multiple interactions

evodiamine inhibits the reaction [Nitroglycerin results in increased expression of and results in increased phosphorylation of GRIA1 protein]; Nitroglycerin results in increased expression of and results in increased phosphorylation of GRIA1 protein

NCBI chr10:41,710,540...42,030,105
Ensembl chr10:41,210,713...41,527,283

G

G protein-coupled receptor kinase 6

decreases expression

Nitroglycerin results in decreased expression of GRK6 mRNA

NCBI chr17:9,182,160...9,198,380
Ensembl chr17:9,177,019...9,192,644

G

granulin precursor

decreases expression

Nitroglycerin results in decreased expression of GRN mRNA

NCBI chr10:87,887,834...87,893,938
Ensembl chr10:87,387,638...87,393,775

G

gelsolin

increases expression

Nitroglycerin results in increased expression of GSN mRNA

NCBI chr 3:38,982,605...39,035,849
Ensembl chr 3:18,585,172...18,638,402

G

glutathione S-transferase alpha 2

decreases expression

Nitroglycerin results in decreased expression of GSTA2 mRNA

NCBI chr 8:88,064,829...88,077,168
Ensembl chr 8:79,184,322...79,196,798

G

glutathione S-transferase alpha 3

affects metabolic processing

GSTA3 protein affects the metabolism of Nitroglycerin

NCBI chr 9:31,154,989...31,180,653
Ensembl chr 9:23,658,574...23,684,240

G

glutathione S-transferase mu 2

affects metabolic processing

GSTM2 protein affects the metabolism of Nitroglycerin

NCBI chr 2:198,312,179...198,316,962
Ensembl chr 2:195,544,426...195,628,961

G

general transcription factor IIIC subunit 1

increases expression

Nitroglycerin results in increased expression of GTF3C1 mRNA

NCBI chr 1:189,634,645...189,700,848
Ensembl chr 1:180,203,995...180,270,201

G

guanylate cyclase 1 soluble subunit alpha 1

increases expression

Nitroglycerin results in increased expression of GUCY1A1 mRNA; Nitroglycerin results in increased expression of GUCY1A1 protein

NCBI chr 2:169,716,684...169,780,360
Ensembl chr 2:167,418,640...167,481,671

G

guanylate cyclase 1 soluble subunit beta 1

increases expression

Nitroglycerin results in increased expression of GUCY1B1 protein
Nitroglycerin results in increased expression of GUCY1B1 mRNA; Nitroglycerin results in increased expression of GUCY1B1 protein

PMID:11331261 PMID:11742226 PMID:17541025

NCBI chr 2:169,646,897...169,697,060
Ensembl chr 2:167,348,825...167,398,916

G

hemoglobin subunit beta

increases expression

Nitroglycerin results in increased expression of HBB mRNA

NCBI chr 1:167,662,310...167,663,721
Ensembl chr 1:158,120,200...158,252,012

G

histidine decarboxylase

decreases expression

Nitroglycerin results in decreased expression of HDC mRNA

NCBI chr 3:134,300,628...134,318,704
Ensembl chr 3:113,847,260...113,865,341

G

heme oxygenase 1

increases expression
multiple interactions

Nitroglycerin results in increased expression of HMOX1 mRNA
[Hemin co-treated with Nitroglycerin] results in increased expression of HMOX1 mRNA; [Hemin co-treated with Nitroglycerin] results in increased expression of HMOX1 protein

PMID:17092343 PMID:17470570 PMID:17541025

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079

G

hepsin

increases expression

Nitroglycerin results in increased expression of HPN mRNA

NCBI chr 1:95,464,468...95,480,169
Ensembl chr 1:86,337,087...86,352,811

G

islet amyloid polypeptide

increases expression

Nitroglycerin results in increased expression of IAPP mRNA

NCBI chr 4:176,968,097...176,975,363
Ensembl chr 4:175,237,115...175,242,920

G

inhibitor of DNA binding 2

increases expression

Nitroglycerin results in increased expression of ID2 mRNA

NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:41,728,946...41,744,400

G

indoleamine 2,3-dioxygenase 1

decreases expression

Nitroglycerin results in decreased expression of IDO1 protein

NCBI chr16:74,133,259...74,145,328
Ensembl chr16:67,430,578...67,442,730

G

interleukin 1 beta

increases expression
multiple interactions

Nitroglycerin results in increased expression of IL1B protein
rizatriptan inhibits the reaction [Nitroglycerin results in increased expression of IL1B protein]; yufengningxin inhibits the reaction [Nitroglycerin results in increased expression of IL1B protein]

PMID:11701602 PMID:36924863

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

increases expression

Nitroglycerin results in increased expression of IL6 mRNA; Nitroglycerin results in increased expression of IL6 protein

PMID:11701602 PMID:17470570

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

jumping translocation breakpoint

increases expression

Nitroglycerin results in increased expression of JTB mRNA

NCBI chr 2:177,983,033...177,987,250
Ensembl chr 2:175,684,993...175,690,108

G

kynurenine 3-monooxygenase

decreases expression

Nitroglycerin results in decreased expression of KMO protein

NCBI chr13:90,089,340...90,121,108
Ensembl chr13:87,557,286...87,588,881

G

kininogen 2

decreases expression

Nitroglycerin results in decreased expression of KNG2 mRNA

NCBI chr11:91,418,470...91,440,841
Ensembl chr11:77,909,612...78,002,971

G

kynureninase

decreases expression

Nitroglycerin results in decreased expression of KYNU protein

NCBI chr 3:48,188,286...48,338,996
Ensembl chr 3:27,778,772...27,929,488

G

monoamine oxidase B

increases expression

Nitroglycerin results in increased expression of MAOB mRNA

NCBI chr X:8,490,405...8,594,065
Ensembl chr X:5,907,266...6,011,003

G

mitochondrial trans-2-enoyl-CoA reductase

decreases expression

Nitroglycerin results in decreased expression of MECR mRNA

NCBI chr 5:149,313,765...149,339,964
Ensembl chr 5:144,029,731...144,055,863

G

monoglyceride lipase

multiple interactions
increases activity

Nitroglycerin promotes the reaction [MGLL protein results in increased chemical synthesis of Glycerol]; Nitroglycerin promotes the reaction [MGLL protein results in increased degradation of 2-oleoylglycerol]
Nitroglycerin results in increased activity of MGLL protein

NCBI chr 4:122,749,436...122,851,440
Ensembl chr 4:121,192,195...121,294,179

G

matrix metallopeptidase 2

increases expression

Nitroglycerin results in increased expression of MMP2 mRNA

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 7

increases expression

Nitroglycerin results in increased expression of MMP7 mRNA

NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:4,848,186...4,855,902

G

matrix metallopeptidase 9

increases activity
increases expression

Nitroglycerin results in increased activity of MMP9 protein
Nitroglycerin results in increased expression of MMP9 mRNA

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

decreases activity

Nitroglycerin results in decreased activity of MPO protein

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819

G

MAX interactor 1, dimerization protein

increases expression

Nitroglycerin results in increased expression of MXI1 mRNA

NCBI chr 1:262,329,274...262,389,037
Ensembl chr 1:252,323,303...252,383,681

G

myosin IXb

decreases expression

Nitroglycerin results in decreased expression of MYO9B mRNA

NCBI chr16:17,979,374...18,064,100
Ensembl chr16:17,945,448...18,030,126

G

neural cell adhesion molecule 1

increases expression

Nitroglycerin results in increased expression of NCAM1 mRNA

NCBI chr 8:58,762,088...59,062,131
Ensembl chr 8:49,865,633...50,166,014

G

neutrophil cytosolic factor 1

decreases response to substance
multiple interactions

NCF1 gene mutant form results in decreased susceptibility to Nitroglycerin
NCF1 gene mutant form inhibits the reaction [Nitroglycerin results in decreased susceptibility to Acetylcholine]

NCBI chr12:28,121,816...28,131,080
Ensembl chr12:22,485,451...22,494,646

G

NADH:ubiquinone oxidoreductase subunit A5

decreases expression

Nitroglycerin results in decreased expression of NDUFA5 mRNA

NCBI chr 4:53,962,877...53,971,235
Ensembl chr 4:52,995,546...53,005,598
Ensembl chr 5:52,995,546...53,005,598

G

NK2 homeobox 1

decreases expression

Nitroglycerin results in decreased expression of NKX2-1 mRNA

NCBI chr 6:79,731,677...79,735,952
Ensembl chr 6:73,996,601...73,999,791

G

neuronatin

increases expression

Nitroglycerin results in increased expression of NNAT mRNA

NCBI chr 3:166,646,373...166,648,845
Ensembl chr 3:146,226,407...146,228,834

G

nitric oxide synthase 1

multiple interactions
increases expression

acetylsalicylic acid lysinate inhibits the reaction [Nitroglycerin results in increased expression of NOS1 protein]; Sumatriptan inhibits the reaction [Nitroglycerin results in increased expression of NOS1 protein]

PMID:14510930 PMID:15154853

NCBI chr12:44,276,011...44,456,371
Ensembl chr12:38,626,714...38,710,945

G

nitric oxide synthase 2

decreases expression
multiple interactions
increases expression

Nitroglycerin results in decreased expression of NOS2 mRNA
NOS2 protein affects the reaction [Nitroglycerin results in increased expression of CALCA mRNA]
Nitroglycerin results in increased expression of NOS2 mRNA; Nitroglycerin results in increased expression of NOS2 protein
Nitroglycerin results in decreased expression of NOS2 protein

PMID:11701602 PMID:12206003 PMID:14729435 PMID:14732477

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

multiple interactions
increases expression

[Nitroglycerin co-treated with Hemin] results in increased expression of NOS3 mRNA; Nitroglycerin promotes the reaction [[Calcimycin results in increased activity of NOS3 protein] which results in increased abundance of Superoxides]
Nitroglycerin results in increased expression of NOS3 mRNA; Nitroglycerin results in increased expression of NOS3 protein

PMID:10625313 PMID:12860443 PMID:14732477 PMID:17541025

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166

G

NADPH oxidase 1

decreases expression

Nitroglycerin results in decreased expression of NOX1 mRNA

NCBI chr X:101,572,338...101,625,571
Ensembl chr X:97,279,056...97,302,236

G

NADPH oxidase 4

decreases expression

Nitroglycerin results in decreased expression of NOX4 mRNA

NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:140,901,097...141,077,406

G

neuropeptide Y

increases expression

Nitroglycerin results in increased expression of NPY protein

NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:78,881,264...78,888,495

G

phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase

increases expression

Nitroglycerin results in increased expression of PAICS mRNA

NCBI chr14:31,553,355...31,586,843
Ensembl chr14:31,173,541...31,232,635

G

poly (ADP-ribose) polymerase 1

decreases expression

Nitroglycerin results in decreased expression of PARP1 protein alternative form

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404

G

proprotein convertase subtilisin/kexin type 1 inhibitor

decreases expression

Nitroglycerin results in decreased expression of PCSK1N mRNA

NCBI chr X:17,251,963...17,255,405
Ensembl chr X:14,580,038...14,583,566

G

phosphodiesterase 1A

increases expression
multiple interactions

Nitroglycerin results in increased expression of PDE1A mRNA; Nitroglycerin results in increased expression of PDE1A protein
PDE1A protein inhibits the reaction [Nitroglycerin results in increased abundance of Cyclic GMP]

NCBI chr 3:85,152,053...85,432,289
Ensembl chr 3:64,747,269...65,024,874

G

phosphodiesterase 2A

increases expression

Nitroglycerin results in increased expression of PDE2A mRNA

NCBI chr 1:165,235,623...165,327,466
Ensembl chr 1:155,813,180...155,915,434

G

phospholipase A2 group IB

increases expression

Nitroglycerin results in increased expression of PLA2G1B mRNA

NCBI chr12:46,802,932...46,814,511
Ensembl chr12:41,142,200...41,153,226

G

plasminogen activator, urokinase receptor

increases expression

Nitroglycerin results in increased expression of PLAUR mRNA

NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:80,050,324...80,068,595

G

peripheral myelin protein 22

decreases expression

Nitroglycerin results in decreased expression of PMP22 mRNA

NCBI chr10:48,294,932...48,324,941
Ensembl chr10:47,795,709...47,825,714

G

RNA polymerase I subunit B

increases expression

Nitroglycerin results in increased expression of POLR1B mRNA

NCBI chr 3:136,787,130...136,811,608
Ensembl chr 3:116,333,889...116,358,379

G

protein phosphatase 2 catalytic subunit beta

decreases expression

Nitroglycerin results in decreased expression of PPP2CB mRNA

NCBI chr16:65,261,178...65,282,658
Ensembl chr16:58,558,122...58,579,576

G

protein kinase cGMP-dependent 1

decreases expression

Nitroglycerin results in decreased expression of PRKG1 protein

NCBI chr 1:237,818,950...239,052,184
Ensembl chr 1:228,408,947...229,639,080

G

prostaglandin D2 synthase

increases expression

Nitroglycerin results in increased expression of PTGDS mRNA

NCBI chr 3:28,680,044...28,682,978
Ensembl chr 3:8,281,899...8,284,833

G

protein tyrosine phosphatase, receptor type, R

increases expression

Nitroglycerin results in increased expression of PTPRR mRNA

NCBI chr 7:53,548,611...53,815,632
Ensembl chr 7:51,662,595...51,929,603

G

Rab40c, member RAS oncogene family

increases expression

Nitroglycerin results in increased expression of RAB40C mRNA

NCBI chr10:15,405,436...15,440,659
Ensembl chr10:14,900,929...14,936,557

G

regenerating family member 3 beta

increases expression

Nitroglycerin results in increased expression of REG3B mRNA

NCBI chr 4:112,419,776...112,423,014
Ensembl chr 4:110,861,775...110,865,015

G

RELA proto-oncogene, NF-kB subunit

increases localization
increases expression
multiple interactions

Nitroglycerin results in increased localization of RELA protein
Nitroglycerin results in increased expression of RELA mRNA
Atorvastatin inhibits the reaction [Nitroglycerin results in increased localization of RELA protein]; Nitroglycerin results in increased expression of and results in increased phosphorylation of RELA protein; rizatriptan inhibits the reaction [Nitroglycerin results in increased expression of and results in increased phosphorylation of RELA protein]; rizatriptan inhibits the reaction [Nitroglycerin results in increased expression of RELA mRNA]; yufengningxin inhibits the reaction [Nitroglycerin results in increased expression of and results in increased phosphorylation of RELA protein]; yufengningxin inhibits the reaction [Nitroglycerin results in increased expression of RELA mRNA]

PMID:19733216 PMID:36924863

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484

G

renin

increases activity

Nitroglycerin results in increased activity of REN protein

NCBI chr13:47,348,312...47,359,539
Ensembl chr13:44,796,091...44,807,489

G

regulator of G-protein signaling 8

increases expression

Nitroglycerin results in increased expression of RGS8 mRNA

NCBI chr13:68,355,078...68,399,412
Ensembl chr13:65,804,797...65,846,807

G

Ras homolog, mTORC1 binding

decreases expression

Nitroglycerin results in decreased expression of RHEB mRNA

NCBI chr 4:11,012,173...11,053,860
Ensembl chr 4:10,279,370...10,320,160

G

ribosomal protein L6

decreases expression

Nitroglycerin results in decreased expression of RPL6 mRNA

NCBI chr12:41,008,142...41,012,756
Ensembl chr12:35,347,497...35,351,921

G

ribosomal protein S3a

increases expression

Nitroglycerin results in increased expression of RPS3A mRNA

NCBI chr 2:173,822,673...173,827,042
Ensembl chr 2:171,524,500...171,529,055

G

secretoglobin family 1A member 1

decreases expression

Nitroglycerin results in decreased expression of SCGB1A1 mRNA

NCBI chr 1:215,406,138...215,409,686
Ensembl chr 1:205,977,060...205,980,610

G

syndecan 4

decreases expression

Nitroglycerin results in decreased expression of SDC4 mRNA

NCBI chr 3:173,574,239...173,592,923
Ensembl chr 3:153,154,896...153,173,580

G

serpin family A member 3N

decreases expression

Nitroglycerin results in decreased expression of SERPINA3N mRNA

NCBI chr 6:129,088,392...129,095,950
Ensembl chr 6:123,323,629...123,332,433

G

SH3 and multiple ankyrin repeat domains 2

increases expression

Nitroglycerin results in increased expression of SHANK2 mRNA

NCBI chr 1:208,575,144...209,020,300
Ensembl chr 1:199,169,429...199,589,394

G

solute carrier family 4 member 4

increases expression

Nitroglycerin results in increased expression of SLC4A4 mRNA

NCBI chr14:19,125,394...19,577,379
Ensembl chr14:18,845,159...19,272,883

G

stannin

decreases expression

Nitroglycerin results in decreased expression of SNN mRNA

NCBI chr10:5,079,885...5,088,565
Ensembl chr10:4,572,376...4,584,021
Ensembl chr 1:4,572,376...4,584,021

G

SNF related kinase

increases expression

Nitroglycerin results in increased expression of SNRK mRNA

NCBI chr 8:130,657,204...130,711,461
Ensembl chr 8:121,793,302...121,832,323

G

superoxide dismutase 2

multiple interactions

Nitroglycerin results in increased expression of and results in increased activity of SOD2 protein

PMID:12860443 PMID:14732477

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189

G

signal transducer and activator of transcription 3

increases expression

Nitroglycerin results in increased expression of STAT3 mRNA

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057

G

spleen associated tyrosine kinase

increases expression

Nitroglycerin results in increased expression of SYK mRNA

NCBI chr17:12,756,493...12,830,927
Ensembl chr17:12,604,619...12,661,410

G

synapsin II

increases expression

Nitroglycerin results in increased expression of SYN2 mRNA

NCBI chr 4:149,858,919...150,016,845
Ensembl chr 4:148,186,270...148,344,192

G

tachykinin, precursor 1

affects expression

Nitroglycerin affects the expression of TAC1 protein

NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:35,679,704...35,687,178

G

transcription factor 4

multiple interactions

Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]]

NCBI chr18:65,216,840...65,563,186
Ensembl chr18:62,943,782...63,284,425

G

tryptophan 2,3-dioxygenase

decreases expression

Nitroglycerin results in decreased expression of TDO2 protein

NCBI chr 2:169,567,656...169,585,586
Ensembl chr 2:167,269,579...167,287,511

G

Thy-1 cell surface antigen

decreases expression

Nitroglycerin results in decreased expression of THY1 mRNA

NCBI chr 8:53,286,396...53,291,541
Ensembl chr 8:44,389,513...44,394,659

G

thymopoietin

increases expression

Nitroglycerin results in increased expression of TMPO mRNA

NCBI chr 7:27,529,977...27,554,980
Ensembl chr 7:25,586,725...25,667,727

G

tumor necrosis factor

decreases expression
multiple interactions

Nitroglycerin results in decreased expression of TNF protein
Capsaicin inhibits the reaction [Nitroglycerin results in decreased expression of TNF protein]; Methylene Blue inhibits the reaction [Nitroglycerin results in decreased expression of TNF protein]

PMID:10884648 PMID:11744139

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 8

decreases expression

Nitroglycerin results in decreased expression of TNFRSF8 mRNA

NCBI chr 5:162,406,387...162,451,620
Ensembl chr 5:157,123,185...157,168,421

G

uromodulin

increases expression

Nitroglycerin results in increased expression of UMOD mRNA

NCBI chr 1:183,247,676...183,261,665
Ensembl chr 1:173,816,339...173,830,302

G

vasodilator-stimulated phosphoprotein

multiple interactions
increases phosphorylation
decreases phosphorylation

1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitroglycerin results in increased phosphorylation of VASP protein]
Nitroglycerin results in decreased phosphorylation of VASP protein
Benomyl inhibits the reaction [Nitroglycerin results in increased phosphorylation of VASP protein]; Hemin inhibits the reaction [Nitroglycerin results in decreased phosphorylation of VASP protein]

PMID:11331261 PMID:14551241 PMID:15331769 PMID:17541025 PMID:17868048 More...

NCBI chr 1:88,038,026...88,053,783
Ensembl chr 1:78,910,011...78,925,061

G

vitronectin

increases expression

Nitroglycerin results in increased expression of VTN mRNA

NCBI chr10:63,892,782...63,895,862
Ensembl chr10:63,394,719...63,397,810

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta

decreases expression

Nitroglycerin results in decreased expression of YWHAZ mRNA

NCBI chr 7:69,826,404...69,848,702
Ensembl chr 7:67,940,017...67,963,668

orphenadrine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-1-B glycoprotein like 1

affects expression

Orphenadrine affects the expression of A1BGL1 mRNA

NCBI chr 7:92,314,930...92,318,652
Ensembl chr 7:92,314,562...92,317,941

G

alpha-2-macroglobulin

affects expression

Orphenadrine affects the expression of A2M mRNA

NCBI chr 4:156,570,163...156,619,870
Ensembl chr 4:154,897,877...154,947,786

G

ATP-binding cassette, sub-family B member 1B

affects expression

Orphenadrine affects the expression of ABCB1B mRNA

NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily C member 2

multiple interactions

[Orphenadrine co-treated with Diethylnitrosamine] results in increased expression of ABCC2 mRNA

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

affects expression

Orphenadrine affects the expression of ABCC3 mRNA

NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily D member 2

affects expression

Orphenadrine affects the expression of ABCD2 mRNA

NCBI chr 7:124,142,597...124,191,202
Ensembl chr 7:122,263,032...122,311,642

G

actin binding LIM protein family, member 3

affects expression

Orphenadrine affects the expression of ABLIM3 mRNA

NCBI chr18:57,527,917...57,646,936
Ensembl chr18:55,257,583...55,376,380

G

angiotensin converting enzyme 2

affects expression

Orphenadrine affects the expression of ACE2 mRNA

NCBI chr X:33,925,458...33,972,851
Ensembl chr X:30,293,589...30,340,977

G

alkaline ceramidase 3

affects expression

Orphenadrine affects the expression of ACER3 mRNA

NCBI chr 1:161,915,397...162,017,802
Ensembl chr 1:152,504,186...152,606,591

G

acyl-CoA synthetase long-chain family member 5

affects expression

Orphenadrine affects the expression of ACSL5 mRNA

NCBI chr 1:264,294,851...264,341,943
Ensembl chr 1:254,292,521...254,336,607

G

acyl-CoA synthetase medium-chain family member 3

affects expression

Orphenadrine affects the expression of ACSM3 mRNA

NCBI chr 1:183,564,652...183,591,328
Ensembl chr 1:174,133,288...174,160,184

G

adhesion G protein-coupled receptor G2

affects expression

Orphenadrine affects the expression of ADGRG2 mRNA

NCBI chr X:38,106,067...38,231,286
Ensembl chr X:34,297,402...34,422,609

G

adhesion G protein-coupled receptor V1

affects expression

Orphenadrine affects the expression of ADGRV1 mRNA

NCBI chr 2:13,067,149...13,647,407
Ensembl chr 2:11,331,442...11,911,688

G

alcohol dehydrogenase 4 (class II), pi polypeptide

affects expression

Orphenadrine affects the expression of ADH4 mRNA

NCBI chr 2:229,622,092...229,640,120
Ensembl chr 2:226,947,466...226,987,591

G

adenosine A1 receptor

affects expression

Orphenadrine affects the expression of ADORA1 mRNA

NCBI chr13:48,210,922...48,247,826
Ensembl chr13:45,658,872...45,695,801

G

adenosine A2a receptor

affects expression

Orphenadrine affects the expression of ADORA2A mRNA

NCBI chr20:13,315,270...13,332,802
Ensembl chr20:13,315,853...13,333,386

G

adrenoceptor beta 2

affects expression

Orphenadrine affects the expression of ADRB2 mRNA

NCBI chr18:57,912,760...57,914,802
Ensembl chr18:55,502,903...55,644,512

G

ajuba LIM protein

affects expression

Orphenadrine affects the expression of JUB mRNA

NCBI chr15:31,989,796...32,000,042
Ensembl chr15:28,019,778...28,030,021

G

aldo-keto reductase family 7 member A3

affects expression

Orphenadrine affects the expression of AKR7A3 mRNA

NCBI chr 5:156,876,721...156,884,599
Ensembl chr 5:151,584,479...151,601,394

G

aldehyde dehydrogenase 1 family, member A1

affects expression

Orphenadrine affects the expression of ALDH1A1 mRNA

NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:218,042,127...218,152,961

G

alkaline phosphatase, biomineralization associated

affects expression

Orphenadrine affects the expression of ALPL mRNA

NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:149,951,409...150,006,446

G

ALS2 C-terminal like

affects expression

Orphenadrine affects the expression of ALS2CL mRNA

NCBI chr 8:119,746,498...119,762,824
Ensembl chr 8:110,864,975...110,884,419

G

adhesion molecule with Ig like domain 3

affects expression

Orphenadrine affects the expression of AMIGO3 mRNA

NCBI chr 8:117,620,499...117,622,025
Ensembl chr 8:108,693,060...108,744,555

G

angiomotin like 2

affects expression

Orphenadrine affects the expression of AMOTL2 mRNA

NCBI chr 8:112,182,060...112,198,032
Ensembl chr 8:103,302,992...103,318,910

G

angiopoietin-like 4

affects expression

Orphenadrine affects the expression of ANGPTL4 mRNA

NCBI chr 7:15,252,450...15,259,971
Ensembl chr 7:14,550,311...14,556,519

G

angiopoietin-like 6

affects expression

Orphenadrine affects the expression of ANGPTL6 mRNA

NCBI chr 8:27,689,804...27,696,172
Ensembl chr 8:19,413,619...19,419,925

G

ankyrin repeat domain 9

affects expression

Orphenadrine affects the expression of ANKRD9 mRNA

NCBI chr 6:135,827,355...135,830,002
Ensembl chr 6:129,998,486...130,008,923

G

anoctamin 1

affects expression

Orphenadrine affects the expression of ANO1 mRNA

NCBI chr 1:209,180,755...209,329,413
Ensembl chr 1:199,751,439...199,900,069

G

annexin A5

affects expression

Orphenadrine affects the expression of ANXA5 mRNA

NCBI chr 2:121,242,133...121,272,935
Ensembl chr 2:119,314,007...119,353,369

G

amyloid beta precursor protein

affects expression

Orphenadrine affects the expression of APP mRNA

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561

G

aquaporin 9

affects expression

Orphenadrine affects the expression of AQP9 mRNA

NCBI chr 8:80,678,027...80,718,273
Ensembl chr 8:71,797,234...71,837,395

G

Rho GTPase activating protein 10

affects expression

Orphenadrine affects the expression of ARHGAP10 mRNA

NCBI chr19:30,448,572...30,710,315
Ensembl chr19:30,448,637...30,710,313

G

Rho GTPase activating protein 22

affects expression

Orphenadrine affects the expression of ARHGAP22 mRNA

NCBI chr16:8,480,222...8,637,823
Ensembl chr16:8,476,306...8,631,548

G

Rho guanine nucleotide exchange factor 10

affects expression

Orphenadrine affects the expression of ARHGEF10 mRNA

NCBI chr16:81,349,429...81,440,439
Ensembl chr16:74,647,153...74,738,173

G

Rho guanine nucleotide exchange factor 15

affects expression

Orphenadrine affects the expression of ARHGEF15 mRNA

NCBI chr10:54,149,372...54,162,128
Ensembl chr10:53,650,553...53,663,913

G

armadillo repeat containing, X-linked 1

affects expression

Orphenadrine affects the expression of ARMCX1 mRNA

NCBI chr X:102,192,225...102,196,130
Ensembl chr X:97,898,883...97,903,299

G

arrestin domain containing 2

affects expression

Orphenadrine affects the expression of ARRDC2 mRNA

NCBI chr16:18,635,883...18,640,019
Ensembl chr16:18,601,897...18,606,029

G

activating transcription factor 3

affects expression

Orphenadrine affects the expression of ATF3 mRNA

NCBI chr13:105,274,103...105,331,653
Ensembl chr13:102,751,321...102,764,631

G

ATPase plasma membrane Ca2+ transporting 2

affects expression

Orphenadrine affects the expression of ATP2B2 mRNA

NCBI chr 4:148,450,207...148,763,653
Ensembl chr 4:146,896,332...147,140,665

G

attractin like 1

affects expression

Orphenadrine affects the expression of ATRNL1 mRNA

NCBI chr 1:266,676,051...267,216,847
Ensembl chr 1:256,670,627...257,213,197

G

antizyme inhibitor 2

affects expression

Orphenadrine affects the expression of AZIN2 mRNA

NCBI chr 5:146,568,187...146,594,777
Ensembl chr 5:141,281,249...141,310,397

G

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9

affects expression

Orphenadrine affects the expression of B3GNT9 mRNA

NCBI chr19:50,039,649...50,042,206
Ensembl chr19:33,128,142...33,132,344

G

beta-1,4-galactosyltransferase 6

affects expression

Orphenadrine affects the expression of B4GALT6 mRNA

NCBI chr18:12,233,350...12,290,204
Ensembl chr18:11,958,390...12,015,247

G

BMP and activin membrane-bound inhibitor

affects expression

Orphenadrine affects the expression of BAMBI mRNA

NCBI chr17:58,816,438...58,821,003
Ensembl chr17:54,121,255...54,126,060

G

Bcl-2 binding component 3

affects expression

Orphenadrine affects the expression of BBC3 mRNA

NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:77,014,543...77,022,509

G

BCL6, transcription repressor

affects expression

Orphenadrine affects the expression of BCL6 mRNA

NCBI chr11:90,358,753...90,382,049
Ensembl chr11:76,854,090...76,877,389

G

beta-carotene oxygenase 2

affects expression

Orphenadrine affects the expression of BCO2 mRNA

NCBI chr 8:59,778,571...59,803,597
Ensembl chr 8:50,882,181...50,915,467

G

basic helix-loop-helix family, member a15

affects expression

Orphenadrine affects the expression of BHLHA15 mRNA

NCBI chr12:15,534,123...15,538,299
Ensembl chr12:10,420,467...10,424,713

G

BicC family RNA binding protein 1

affects expression

Orphenadrine affects the expression of BICC1 mRNA

NCBI chr20:17,448,745...17,685,887
Ensembl chr20:17,449,560...17,686,776

G

bone morphogenetic protein 4

affects expression

Orphenadrine affects the expression of BMP4 mRNA

NCBI chr15:22,098,191...22,113,145
Ensembl chr15:19,618,542...19,623,306

G

BTB domain containing 7

affects expression

Orphenadrine affects the expression of BTBD7 mRNA

NCBI chr 6:127,685,185...127,774,947
Ensembl chr 6:121,923,023...121,972,405

G

similar to human chromosome 11 open reading frame 24

affects expression

Orphenadrine affects the expression of C1H11ORF24 mRNA

NCBI chr 1:210,374,426...210,383,191
Ensembl chr 1:200,945,180...200,962,585

G

C1q and TNF related 2

affects expression

Orphenadrine affects the expression of C1QTNF2 mRNA

NCBI chr10:28,443,326...28,460,400
Ensembl chr10:27,941,948...27,959,185

G

similar to human chromosome 15 open reading frame 39

affects expression

Orphenadrine affects the expression of C8H15ORF39 mRNA

NCBI chr 8:66,542,269...66,551,835
Ensembl chr 8:57,645,756...57,655,941

G

calcitonin receptor like receptor

affects expression

Orphenadrine affects the expression of CALCRL mRNA

NCBI chr 3:89,835,071...89,932,616
Ensembl chr 3:69,430,120...69,525,910

G

carbonic anhydrase 1

affects expression

Orphenadrine affects the expression of CA1 mRNA

NCBI chr 2:88,550,681...88,593,454
Ensembl chr 2:86,861,897...86,872,208

G

carbonic anhydrase 2

affects expression

Orphenadrine affects the expression of CA2 mRNA

NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:86,741,626...86,756,818

G

carbonic anhydrase 3

affects expression

Orphenadrine affects the expression of CA3 mRNA

NCBI chr 2:88,491,666...88,501,299
Ensembl chr 2:86,770,420...86,784,280

G

caspase recruitment domain family, member 19

affects expression

Orphenadrine affects the expression of CARD19 mRNA

NCBI chr17:15,432,632...15,445,317
Ensembl chr17:15,432,612...15,445,318

G

caspase 2

affects expression

Orphenadrine affects the expression of CASP2 mRNA

NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:71,149,669...71,167,379

G

Cbl proto-oncogene C

affects expression

Orphenadrine affects the expression of CBLC mRNA

NCBI chr 1:88,567,930...88,584,709
Ensembl chr 1:79,439,977...79,456,755

G

chromobox 4

affects expression

Orphenadrine affects the expression of CBX4 mRNA

NCBI chr10:104,835,685...104,841,727
Ensembl chr10:104,336,876...104,356,706

G

coiled-coil domain containing 68

affects expression

Orphenadrine affects the expression of CCDC68 mRNA

NCBI chr18:65,817,232...65,859,529
Ensembl chr18:63,541,896...63,584,119

G

cellular communication network factor 1

affects expression

Orphenadrine affects the expression of CCN1 mRNA

NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:234,562,408...234,565,484

G

cyclin D1

multiple interactions

Orphenadrine promotes the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA]

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D2

affects expression

Orphenadrine affects the expression of CCND2 mRNA

NCBI chr 4:161,653,048...161,675,422
Ensembl chr 4:159,962,363...159,989,495

G

CD24 molecule

affects expression

Orphenadrine affects the expression of CD24 mRNA

NCBI chr20:48,655,549...48,661,786
Ensembl chr20:47,073,512...47,079,662

G

Cd276 molecule

affects expression

Orphenadrine affects the expression of CD276 mRNA

NCBI chr 8:67,833,587...67,863,918
Ensembl chr 8:58,937,751...58,968,380

G

CD36 molecule

affects expression

Orphenadrine affects the expression of CD36 mRNA

NCBI chr 4:18,209,088...18,302,142
Ensembl chr 4:17,354,466...17,513,903

G

CDC42 effector protein 1

affects expression

Orphenadrine affects the expression of CDC42EP1 mRNA

NCBI chr 7:112,275,759...112,283,665
Ensembl chr 7:110,395,332...110,403,200

G

cadherin 3

affects expression

Orphenadrine affects the expression of CDH3 mRNA

NCBI chr19:51,303,414...51,353,900
Ensembl chr19:34,393,727...34,444,084

G

cerebellar degeneration-related protein 2

affects expression

Orphenadrine affects the expression of CDR2 mRNA

NCBI chr 1:184,934,128...184,959,036
Ensembl chr 1:175,502,838...175,537,472

G

carboxylesterase 2H

affects expression

Orphenadrine affects the expression of CES2 mRNA

NCBI chr19:49,884,164...49,898,764
Ensembl chr19:32,974,242...32,988,830

G

cilia and flagella associated protein 68

affects expression

Orphenadrine affects the expression of CFAP68 mRNA

NCBI chr 8:60,004,034...60,009,782
Ensembl chr 8:51,107,721...51,113,420

G

cell growth regulator with EF hand domain 1

affects expression

Orphenadrine affects the expression of CGREF1 mRNA

NCBI chr 6:31,151,795...31,163,801
Ensembl chr 6:25,431,799...25,443,852

G

charged multivesicular body protein 4C

affects expression

Orphenadrine affects the expression of CHMP4C mRNA

NCBI chr 2:93,299,152...93,336,075
Ensembl chr 2:91,388,530...91,428,668

G

cell death-inducing DFFA-like effector a

affects expression

Orphenadrine affects the expression of CIDEA mRNA

NCBI chr18:63,164,817...63,190,384
Ensembl chr18:60,894,874...60,920,481

G

cytokine inducible SH2-containing protein

affects expression

Orphenadrine affects the expression of CISH mRNA

NCBI chr 8:116,850,969...116,855,917
Ensembl chr 8:107,972,306...107,977,250

G

cardiotrophin-like cytokine factor 1

affects expression

Orphenadrine affects the expression of CLCF1 mRNA

NCBI chr 1:210,937,763...210,947,064
Ensembl chr 1:201,507,859...201,517,605

G

claudin 23

affects expression

Orphenadrine affects the expression of CLDN23 mRNA

NCBI chr16:63,117,045...63,118,769
Ensembl chr16:56,413,381...56,415,523

G

carnosine dipeptidase 1

affects expression

Orphenadrine affects the expression of CNDP1 mRNA

NCBI chr18:80,254,499...80,305,845
Ensembl chr18:77,984,907...78,007,765

G

collagen type IV alpha 3 chain

affects expression

Orphenadrine affects the expression of COL4A3 mRNA

NCBI chr 9:91,323,990...91,453,088
Ensembl chr 9:83,875,561...84,001,895

G

carnitine palmitoyltransferase 1B

affects expression

Orphenadrine affects the expression of CPT1B mRNA

NCBI chr 7:122,370,974...122,380,473
Ensembl chr 7:120,491,354...120,500,404

G

carnitine O-acetyltransferase

affects expression

Orphenadrine affects the expression of CRAT mRNA

NCBI chr 3:34,073,504...34,087,099
Ensembl chr 3:13,675,684...13,689,255

G

cytokine receptor-like factor 2

affects expression

Orphenadrine affects the expression of CRLF2 mRNA

NCBI chr14:118,932...123,632
Ensembl chr14:103,939...108,642

G

crystallin, alpha B

affects expression

Orphenadrine affects the expression of CRYAB mRNA

NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:51,093,441...51,099,157

G

crystallin, lambda 1

affects expression

Orphenadrine affects the expression of CRYL1 mRNA

NCBI chr15:35,542,628...35,661,563
Ensembl chr15:31,427,054...31,545,997

G

CUB and Sushi multiple domains 1

affects expression

Orphenadrine affects the expression of CSMD1 mRNA

NCBI chr16:78,920,549...80,520,710
Ensembl chr16:72,218,503...73,817,614

G

cysteine and serine rich nuclear protein 1

affects expression

Orphenadrine affects the expression of CSRNP1 mRNA

NCBI chr 8:128,582,364...128,594,163
Ensembl chr 8:119,704,713...119,718,183

G

cystatin 9-like

affects expression

Orphenadrine affects the expression of CST9L mRNA

NCBI chr 3:156,741,232...156,744,045
Ensembl chr 3:136,288,093...136,290,906

G

CTP synthase 1

affects expression

Orphenadrine affects the expression of CTPS1 mRNA

NCBI chr 5:139,372,349...139,440,441
Ensembl chr 5:134,125,025...134,154,180

G

chymotrypsinogen B1

affects expression

Orphenadrine affects the expression of CTRB mRNA

NCBI chr19:56,562,220...56,566,978
Ensembl chr19:39,652,933...39,657,688

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
affects expression

[Orphenadrine co-treated with Diethylnitrosamine] results in increased expression of CYP1A1 mRNA
Orphenadrine affects the expression of CYP1A1 mRNA

PMID:23665939 PMID:23665940

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
decreases activity

Orphenadrine inhibits the reaction [CYP1A2 protein results in decreased ethylation of 7-ethoxy-4-trifluoromethylcoumarin]; Orphenadrine inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin]
Orphenadrine results in decreased activity of CYP1A2 protein
Orphenadrine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]

PMID:9241656 PMID:18493746

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily b, polypeptide 15

affects expression

Orphenadrine affects the expression of CYP2B15 mRNA

NCBI chr 1:82,094,188...82,106,492
Ensembl chr 1:82,094,180...82,106,492

G

cytochrome P450, family 2, subfamily b, polypeptide 2

affects expression
multiple interactions

Orphenadrine affects the expression of CYP2B2 mRNA
[Orphenadrine co-treated with Phenobarbital] affects the expression of CYP2B2 mRNA

PMID:23665939 PMID:23665940

NCBI chr 1:90,722,243...90,736,272
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions
decreases activity

Orphenadrine inhibits the reaction [CYP2B6 protein results in decreased ethylation of 7-ethoxy-4-trifluoromethylcoumarin]; Orphenadrine inhibits the reaction [CYP2B6 protein results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin]
Orphenadrine results in decreased activity of CYP2B6 protein

PMID:9241656 PMID:12464242 PMID:15306208

NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily c, polypeptide 12

affects expression

Orphenadrine affects the expression of CYP2C12 mRNA

NCBI chr 1:248,619,887...248,681,945
Ensembl chr 1:238,699,854...238,757,019

G

cytochrome P450, family 2, subfamily c, polypeptide 24

affects expression

Orphenadrine affects the expression of CYP2C24 mRNA

NCBI chr 1:246,286,341...246,348,607
Ensembl chr 1:236,873,967...236,936,238

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions
decreases activity

Orphenadrine inhibits the reaction [CYP2E1 protein results in decreased ethylation of 7-ethoxy-4-trifluoromethylcoumarin]; Orphenadrine inhibits the reaction [CYP2E1 protein results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin]
Orphenadrine results in decreased activity of CYP2E1 protein

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 62

affects expression

Orphenadrine affects the expression of CYP3A62 mRNA

NCBI chr12:21,511,763...21,547,598
Ensembl chr12:16,397,998...16,433,833

G

cytochrome P450, family 4, subfamily a, polypeptide 1

affects expression

Orphenadrine affects the expression of CYP4A1 mRNA

NCBI chr 5:134,360,096...134,374,233
Ensembl chr 5:129,123,336...129,137,464

G

cytochrome P450, family 4, subfamily a, polypeptide 8

affects expression

Orphenadrine affects the expression of CYP4A8 mRNA

NCBI chr 5:133,938,882...133,970,226
Ensembl chr 5:128,702,131...128,733,476

G

cytochrome P450, family 4, subfamily b, polypeptide 1

affects expression

Orphenadrine affects the expression of CYP4B1 mRNA

NCBI chr 5:134,375,807...134,413,635
Ensembl chr 5:129,139,038...129,156,348

G

cytochrome P450, family 4, subfamily f, polypeptide 5

affects expression

Orphenadrine affects the expression of CYP4F5 mRNA

NCBI chr 7:12,194,567...12,209,495
Ensembl chr 7:11,544,082...11,558,978

G

cytochrome P450 family 7 subfamily A member 1

affects expression

Orphenadrine affects the expression of CYP7A1 mRNA

NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:19,376,974...19,386,688

G

cytochrome P450 family 8 subfamily B member 1

affects expression

Orphenadrine affects the expression of CYP8B1 mRNA

NCBI chr 8:130,455,622...130,457,592
Ensembl chr 8:121,557,062...121,580,166

G

cysteine-rich transmembrane module containing 1

affects expression

Orphenadrine affects the expression of CYSTM1 mRNA

NCBI chr18:28,219,861...28,287,574
Ensembl chr18:27,951,653...28,013,510

G

cysteine and tyrosine rich 1

affects expression

Orphenadrine affects the expression of CYYR1 mRNA

NCBI chr11:38,044,003...38,150,391
Ensembl chr11:24,515,316...24,663,961

G

dishevelled-binding antagonist of beta-catenin 2

affects expression

Orphenadrine affects the expression of DACT2 mRNA

NCBI chr 1:63,854,182...63,864,153
Ensembl chr 1:55,181,024...55,191,096

G

defensin beta 36

affects expression

Orphenadrine affects the expression of DEFB36 mRNA

NCBI chr 3:141,078,001...141,086,832
Ensembl chr 3:141,086,058...141,086,728

G

disco-interacting protein 2 homolog A

affects expression

Orphenadrine affects the expression of DIP2A mRNA

NCBI chr20:12,284,037...12,373,519
Ensembl chr20:12,284,654...12,370,217

G

delta like canonical Notch ligand 1

affects expression

Orphenadrine affects the expression of DLL1 mRNA

NCBI chr 1:64,985,161...64,993,274
Ensembl chr 1:56,312,066...56,320,179

G

dynein heavy chain domain 1

affects expression

Orphenadrine affects the expression of DNHD1 mRNA

NCBI chr 1:169,402,615...169,486,684
Ensembl chr 1:159,990,438...160,074,858

G

dipeptidyl peptidase like 6

affects expression

Orphenadrine affects the expression of DPP6 mRNA

NCBI chr 4:8,323,220...9,242,694
Ensembl chr 4:7,591,009...8,508,532

G

developmental pluripotency associated 3 like 2

affects expression

Orphenadrine affects the expression of DPPA3L2 mRNA

NCBI chr17:2,886,537...2,887,217

G

DNA-damage regulated autophagy modulator 1

affects expression

Orphenadrine affects the expression of DRAM1 mRNA

NCBI chr 7:24,630,233...24,665,270
Ensembl chr 7:22,742,849...22,776,765

G

dual specificity phosphatase 1

affects expression

Orphenadrine affects the expression of DUSP1 mRNA

NCBI chr10:17,184,853...17,187,646

G

dual specificity phosphatase 10

affects expression

Orphenadrine affects the expression of DUSP10 mRNA

NCBI chr13:98,145,317...98,183,304
Ensembl chr13:95,614,292...95,651,716

G

dual specificity phosphatase 13B

affects expression

Orphenadrine affects the expression of DUSP13B mRNA

NCBI chr15:2,567,432...2,575,105
Ensembl chr15:2,533,547...2,575,539

G

dual specificity phosphatase 16

affects expression

Orphenadrine affects the expression of DUSP16 mRNA

NCBI chr 4:169,278,118...169,361,508
Ensembl chr 4:167,548,155...167,629,980

G

dual specificity phosphatase 8

affects expression

Orphenadrine affects the expression of DUSP8 mRNA

NCBI chr 1:206,596,912...206,613,728
Ensembl chr 1:197,169,422...197,182,921

G

estrogen-induced osteoclastogenesis regulator 1

affects expression

Orphenadrine affects the expression of EEIG1 mRNA

NCBI chr 3:36,220,170...36,252,377
Ensembl chr 3:15,823,144...15,854,643

G

EEIG family member 2

affects expression

Orphenadrine affects the expression of EEIG2 mRNA

NCBI chr 2:199,296,582...199,351,449
Ensembl chr 2:196,608,499...196,663,371

G

EGF containing fibulin extracellular matrix protein 1

affects expression

Orphenadrine affects the expression of EFEMP1 mRNA

NCBI chr14:106,811,769...106,890,961
Ensembl chr14:102,610,908...102,690,018

G

egl-9 family hypoxia-inducible factor 3

affects expression

Orphenadrine affects the expression of EGLN3 mRNA

NCBI chr 6:77,385,549...77,411,015
Ensembl chr 6:71,650,297...71,675,766

G

early growth response 1

affects expression

Orphenadrine affects the expression of EGR1 mRNA

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766

G

elastin microfibril interfacer 1

affects expression

Orphenadrine affects the expression of EMILIN1 mRNA

NCBI chr 6:31,175,919...31,183,657
Ensembl chr 6:25,445,298...25,463,698

G

Eph receptor A2

affects expression

Orphenadrine affects the expression of EPHA2 mRNA

NCBI chr 5:158,888,629...158,917,100
Ensembl chr 5:153,605,644...153,634,117

G

EPH receptor B4

affects expression

Orphenadrine affects the expression of EPHB4 mRNA

NCBI chr12:24,963,174...24,988,473
Ensembl chr12:19,326,427...19,351,314

G

ERI1 exoribonuclease family member 2

affects expression

Orphenadrine affects the expression of ERI2 mRNA

NCBI chr 1:183,551,919...183,600,134
Ensembl chr 1:174,141,993...174,168,665

G

coagulation factor VIII

affects expression

Orphenadrine affects the expression of F8 mRNA

NCBI chr18:155,237...187,186
Ensembl chr18:140,955...171,857

G

family with sequence similarity 89, member A

affects expression

Orphenadrine affects the expression of FAM89A mRNA

NCBI chr19:69,607,391...69,620,019
Ensembl chr19:52,710,019...52,722,631

G

F-box protein 27

affects expression

Orphenadrine affects the expression of FBXO27 mRNA

NCBI chr 1:93,092,900...93,115,312
Ensembl chr 1:83,965,986...83,987,778

G

fer-1-like family member 5

affects expression

Orphenadrine affects the expression of FER1L5 mRNA

NCBI chr 9:46,101,798...46,156,483
Ensembl chr 9:38,607,843...38,660,425

G

FYVE, RhoGEF and PH domain containing 5

affects expression

Orphenadrine affects the expression of FGD5 mRNA

NCBI chr 4:124,497,061...124,594,564
Ensembl chr 4:124,497,068...124,594,563

G

Fms related receptor tyrosine kinase 1

affects expression

Orphenadrine affects the expression of FLT1 mRNA

NCBI chr12:12,333,050...12,504,750
Ensembl chr12:7,297,292...7,468,626

G

Fms related receptor tyrosine kinase 4

affects expression

Orphenadrine affects the expression of FLT4 mRNA

NCBI chr10:34,414,834...34,455,878
Ensembl chr10:33,913,608...33,954,770

G

flavin containing dimethylaniline monoxygenase 1

affects expression

Orphenadrine affects the expression of FMO1 mRNA

NCBI chr13:77,715,405...77,747,666
Ensembl chr13:75,182,176...75,214,647

G

fibronectin type III domain containing 5

affects expression

Orphenadrine affects the expression of FNDC5 mRNA

NCBI chr 5:146,765,951...146,775,611
Ensembl chr 5:141,481,590...141,490,731

G

follistatin

affects expression

Orphenadrine affects the expression of FST mRNA

NCBI chr 2:47,856,345...47,863,670
Ensembl chr 2:46,123,439...46,130,571

G

growth arrest and DNA-damage-inducible, gamma

affects expression

Orphenadrine affects the expression of GADD45G mRNA

NCBI chr17:13,528,606...13,530,351
Ensembl chr17:13,376,839...13,378,610

G

growth differentiation factor 11

affects expression

Orphenadrine affects the expression of GDF11 mRNA

NCBI chr 7:1,896,229...1,909,147
Ensembl chr 7:1,311,732...1,320,725

G

gamma-glutamyltransferase 1

affects expression

Orphenadrine affects the expression of GGT1 mRNA

NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,700...13,108,442

G

GIMAP family P-loop NTPase domain containing 1

affects expression

Orphenadrine affects the expression of GIMD1 mRNA

NCBI chr 2:223,777,876...223,812,582
Ensembl chr 2:221,103,878...221,138,553

G

GIPC PDZ domain containing family, member 2

affects expression

Orphenadrine affects the expression of GIPC2 mRNA

NCBI chr 2:243,690,742...243,770,199
Ensembl chr 2:241,030,770...241,110,236

G

Gem-interacting protein

affects expression

Orphenadrine affects the expression of GMIP mRNA

NCBI chr16:19,600,723...19,614,459
Ensembl chr16:19,600,723...19,614,027

G

G protein subunit alpha 14

affects expression

Orphenadrine affects the expression of GNA14 mRNA

NCBI chr 1:223,141,802...223,324,210
Ensembl chr 1:213,716,020...213,897,423

G

G protein subunit alpha i1

affects expression

Orphenadrine affects the expression of GNAI1 mRNA

NCBI chr 4:17,706,061...17,790,176
Ensembl chr 4:16,814,001...16,896,417

G

glycerol-3-phosphate acyltransferase 3

affects expression

Orphenadrine affects the expression of GPAT3 mRNA

NCBI chr14:9,018,762...9,072,552
Ensembl chr14:8,714,373...8,766,490

G

G protein-coupled receptor 17

affects expression

Orphenadrine affects the expression of GPR17 mRNA

NCBI chr18:23,850,460...23,857,381
Ensembl chr18:23,577,242...23,582,966

G

glutathione peroxidase 2

affects expression
multiple interactions

Orphenadrine affects the expression of GPX2 mRNA
[Orphenadrine co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA; [Phenobarbital co-treated with Orphenadrine] affects the expression of GPX2 mRNA

PMID:23665939 PMID:23665940

NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:95,493,589...95,496,877

G

glutamate ionotropic receptor AMPA type subunit 3

affects expression

Orphenadrine affects the expression of GRIA3 mRNA

NCBI chr X:125,103,975...125,369,690
Ensembl chr X:120,238,534...120,504,096

G

glutamate ionotropic receptor kainate type subunit 5

affects expression

Orphenadrine affects the expression of GRIK5 mRNA

NCBI chr 1:89,733,736...89,795,769
Ensembl chr 1:80,605,892...80,667,125

G

Gse1 coiled-coil protein

affects expression

Orphenadrine affects the expression of GSE1 mRNA

NCBI chr19:65,182,678...65,538,183
Ensembl chr19:48,274,127...48,629,458

G

glutathione S-transferase mu 4

affects expression

Orphenadrine affects the expression of GSTM4 mRNA

NCBI chr 2:198,356,114...198,373,487
Ensembl chr 2:195,680,004...195,685,323

G

glutathione S-transferase, mu 5

multiple interactions
affects expression

[Orphenadrine co-treated with Diethylnitrosamine] results in increased expression of GSTM3 mRNA; [Phenobarbital co-treated with Orphenadrine] affects the expression of GSTM3 mRNA
Orphenadrine affects the expression of GSTM3 mRNA

PMID:23665939 PMID:23665940

NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:195,531,495...195,534,553

G

glutathione S-transferase pi 1

affects expression

Orphenadrine affects the expression of GSTP1 mRNA

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226

G

histidine ammonia lyase

affects expression

Orphenadrine affects the expression of HAL mRNA

NCBI chr 7:29,894,495...29,924,744
Ensembl chr 7:28,006,972...28,037,701

G

heme binding protein 2

affects expression

Orphenadrine affects the expression of HEBP2 mRNA

NCBI chr 1:15,014,729...15,021,523
Ensembl chr 1:13,194,982...13,201,777

G

hes family bHLH transcription factor 1

affects expression

Orphenadrine affects the expression of HES1 mRNA

NCBI chr11:84,210,632...84,213,045
Ensembl chr11:70,705,764...70,708,192

G

hepatocyte growth factor

affects expression

Orphenadrine affects the expression of HGF mRNA

NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:18,677,101...18,745,409

G

HID1 domain containing

affects expression

Orphenadrine affects the expression of HID1 mRNA

NCBI chr10:101,088,526...101,109,011
Ensembl chr10:100,589,555...100,610,041

G

heat shock protein family A (Hsp70) member 1A

affects expression

Orphenadrine affects the expression of HSPA1A mRNA

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 1B

affects expression

Orphenadrine affects the expression of HSPA1B mRNA

NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

hyccin PI4KA lipid kinase complex subunit 1

affects expression

Orphenadrine affects the expression of HYCC1 mRNA

NCBI chr 4:12,024,692...12,131,504
Ensembl chr 4:11,132,385...11,239,113

G

inhibitor of DNA binding 1

affects expression

Orphenadrine affects the expression of ID1 mRNA

NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:141,211,267...141,212,419

G

inhibitor of DNA binding 3

affects expression

Orphenadrine affects the expression of ID3 mRNA

NCBI chr 5:153,656,253...153,657,860
Ensembl chr 5:148,372,762...148,374,349

G

indoleamine 2,3-dioxygenase 2

affects expression

Orphenadrine affects the expression of IDO2 mRNA

NCBI chr16:74,161,761...74,200,651
Ensembl chr16:67,459,190...67,496,324

G

immediate early response 5

affects expression

Orphenadrine affects the expression of IER5 mRNA

NCBI chr13:69,820,450...69,822,542
Ensembl chr13:67,270,135...67,272,227

G

insulin-like growth factor binding protein 1

affects expression

Orphenadrine affects the expression of IGFBP1 mRNA

NCBI chr14:86,261,277...86,266,344
Ensembl chr14:82,047,415...82,052,482

G

Indian hedgehog signaling molecule

affects expression

Orphenadrine affects the expression of IHH mRNA

NCBI chr 9:83,952,986...83,959,203
Ensembl chr 9:76,504,315...76,510,532

G

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

affects expression

Orphenadrine affects the expression of IKBKG mRNA

NCBI chr X:157,358,279...157,397,563
Ensembl chr X:152,216,596...152,239,499

G

interleukin 17 receptor B

affects expression

Orphenadrine affects the expression of IL17RB mRNA

NCBI chr16:5,186,961...5,200,657
Ensembl chr16:5,180,432...5,194,125

G

interleukin 33

affects expression

Orphenadrine affects the expression of IL33 mRNA

NCBI chr 1:237,115,478...237,149,897
Ensembl chr 1:227,721,435...227,736,373

G

inverted formin 2

affects expression

Orphenadrine affects the expression of INF2 mRNA

NCBI chr 6:137,470,259...137,497,039
Ensembl chr 6:131,649,211...131,675,941

G

inositol hexakisphosphate kinase 2

affects expression

Orphenadrine affects the expression of IP6K2 mRNA

NCBI chr 8:118,362,154...118,388,668
Ensembl chr 8:109,484,310...109,510,166

G

interferon regulatory factor 7

affects expression

Orphenadrine affects the expression of IRF7 mRNA

NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:196,367,361...196,370,832

G

iroquois homeobox 1

affects expression

Orphenadrine affects the expression of IRX1 mRNA

NCBI chr 1:33,123,122...33,128,951
Ensembl chr 1:31,294,615...31,300,444

G

ISG15 ubiquitin-like modifier

affects expression

Orphenadrine affects the expression of ISG15 mRNA

NCBI chr 5:172,066,369...172,067,656
Ensembl chr 5:166,784,148...166,785,435

G

integrin subunit beta 3

affects expression

Orphenadrine affects the expression of ITGB3 mRNA

NCBI chr10:90,009,927...90,067,787
Ensembl chr10:89,509,989...89,564,679

G

Jun proto-oncogene, AP-1 transcription factor subunit

affects expression

Orphenadrine affects the expression of JUN mRNA

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656

G

JunB proto-oncogene, AP-1 transcription factor subunit

affects expression

Orphenadrine affects the expression of JUNB mRNA

NCBI chr19:40,081,126...40,082,910
Ensembl chr19:23,176,294...23,178,035

G

type I keratin KA11

affects expression

Orphenadrine affects the expression of KA11 mRNA

NCBI chr10:85,161,424...85,164,737
Ensembl chr10:85,066,802...85,171,799

G

KN motif and ankyrin repeat domains 2

affects expression

Orphenadrine affects the expression of KANK2 mRNA

NCBI chr 8:28,587,770...28,617,212
Ensembl chr 8:20,311,676...20,340,900

G

potassium inwardly-rectifying channel, subfamily J, member 15

affects expression

Orphenadrine affects the expression of KCNJ15 mRNA

NCBI chr11:48,046,953...48,091,285
Ensembl chr11:34,577,363...34,621,952

G

potassium two pore domain channel subfamily K member 5

affects expression

Orphenadrine affects the expression of KCNK5 mRNA

NCBI chr15:4,171,625...4,213,896
Ensembl chr15:4,122,442...4,164,718

G

KLF transcription factor 10

affects expression

Orphenadrine affects the expression of KLF10 mRNA

NCBI chr 7:71,352,612...71,358,680
Ensembl chr 7:69,465,619...69,473,994

G

kelch-like family member 21

affects expression

Orphenadrine affects the expression of KLHL21 mRNA

NCBI chr 5:167,797,621...167,806,276
Ensembl chr 5:162,514,765...162,523,545

G

kynurenine 3-monooxygenase

affects expression

Orphenadrine affects the expression of KMO mRNA

NCBI chr13:90,089,340...90,121,108
Ensembl chr13:87,557,286...87,588,881

G

keratin 10

affects expression

Orphenadrine affects the expression of KRT10 mRNA

NCBI chr10:84,834,865...84,839,160
Ensembl chr10:84,338,706...84,343,701

G

keratin 8

affects expression

Orphenadrine affects the expression of KRT8 mRNA

NCBI chr 7:135,002,886...135,010,339
Ensembl chr 7:133,124,203...133,131,728

G

lymphocyte activating 3

affects expression

Orphenadrine affects the expression of LAG3 mRNA

NCBI chr 4:159,398,930...159,407,001
Ensembl chr 4:157,712,667...157,720,404

G

leucine, glutamate and lysine rich 1

affects expression

Orphenadrine affects the expression of LEKR1 mRNA

NCBI chr 2:152,195,003...152,376,389
Ensembl chr 2:149,891,106...150,060,469

G

galectin 2

affects expression

Orphenadrine affects the expression of LGALS2 mRNA

NCBI chr 7:112,283,630...112,290,228
Ensembl chr 7:110,403,173...110,404,802

G

LIM homeobox 8

affects expression

Orphenadrine affects the expression of LHX8 mRNA

NCBI chr 2:245,904,712...245,929,376
Ensembl chr 2:243,244,961...243,269,416

G

leukocyte immunoglobulin like receptor B4

affects expression

Orphenadrine affects the expression of LILRB4 mRNA

NCBI chr 1:78,847,685...78,853,294
Ensembl chr 1:69,805,250...69,810,660

G

lin-7 homolog A, crumbs cell polarity complex component

affects expression

Orphenadrine affects the expression of LIN7A mRNA

NCBI chr 7:44,473,568...44,629,074
Ensembl chr 7:42,586,719...42,730,550

G

leiomodin 2

affects expression

Orphenadrine affects the expression of LMOD2 mRNA

NCBI chr 4:54,032,974...54,040,670
Ensembl chr 4:53,067,428...53,075,120

G

lysyl oxidase-like 4

affects expression

Orphenadrine affects the expression of LOXL4 mRNA

NCBI chr 1:251,345,445...251,365,640
Ensembl chr 1:241,397,983...241,416,322

G

lysophosphatidylcholine acyltransferase 4

affects expression

Orphenadrine affects the expression of LPCAT4 mRNA

NCBI chr 3:119,499,128...119,507,275
Ensembl chr 3:99,044,729...99,052,875

G

lipin 2

affects expression

Orphenadrine affects the expression of LPIN2 mRNA

NCBI chr 9:118,529,988...118,604,796
Ensembl chr 9:111,083,745...111,158,193

G

lipoprotein lipase

affects expression

Orphenadrine affects the expression of LPL mRNA

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:20,829,465...20,855,249

G

leucine rich repeat neuronal 4

affects expression

Orphenadrine affects the expression of LRRN4 mRNA

NCBI chr 3:140,592,303...140,603,986
Ensembl chr 3:120,139,410...120,150,831

G

leukotriene C4 synthase

affects expression

Orphenadrine affects the expression of LTC4S mRNA

NCBI chr10:35,060,002...35,066,466
Ensembl chr10:34,560,360...34,562,651

G

MAF bZIP transcription factor B

affects expression

Orphenadrine affects the expression of MAFB mRNA

NCBI chr 3:169,417,890...169,419,810
Ensembl chr 3:148,998,122...149,000,031

G

MAGE family member E1

affects expression

Orphenadrine affects the expression of MAGEE1 mRNA

NCBI chr X:74,254,848...74,258,395
Ensembl chr X:70,189,187...70,192,810

G

microtubule-associated protein 1S

affects expression

Orphenadrine affects the expression of MAP1S mRNA

NCBI chr16:18,551,573...18,561,760
Ensembl chr16:18,517,574...18,527,988

G

mitogen activated protein kinase kinase kinase kinase 2

affects expression

Orphenadrine affects the expression of MAP4K2 mRNA

NCBI chr 1:213,074,360...213,090,042
Ensembl chr 1:203,645,153...203,660,331

G

mitogen-activated protein kinase kinase kinase kinase 4

affects expression

Orphenadrine affects the expression of MAP4K4 mRNA

NCBI chr 9:49,696,573...49,822,353
Ensembl chr 9:42,200,278...42,326,698

G

mitogen-activated protein kinase 12

affects expression

Orphenadrine affects the expression of MAPK12 mRNA

NCBI chr 7:122,085,647...122,096,307
Ensembl chr 7:120,206,271...120,216,664

G

matrilin 4

affects expression

Orphenadrine affects the expression of MATN4 mRNA

NCBI chr 3:173,539,966...173,554,984
Ensembl chr 3:153,120,632...153,135,865

G

melanoma cell adhesion molecule

affects expression

Orphenadrine affects the expression of MCAM mRNA

NCBI chr 8:53,376,225...53,384,407
Ensembl chr 8:44,479,376...44,487,571

G

methionyl aminopeptidase type 1D (mitochondrial)

affects expression

Orphenadrine affects the expression of METAP1D mRNA

NCBI chr 3:56,279,471...56,354,518
Ensembl chr 3:56,279,493...56,351,981

G

mex-3 RNA binding family member B

affects expression

Orphenadrine affects the expression of MEX3B mRNA

NCBI chr 1:146,264,319...146,268,554
Ensembl chr 1:136,855,130...136,859,354

G

mex-3 RNA binding family member D

affects expression

Orphenadrine affects the expression of MEX3D mRNA

NCBI chr 7:9,976,253...9,983,383
Ensembl chr 7:9,325,488...9,332,096

G

milk fat globule EGF and factor V/VIII domain containing

affects expression

Orphenadrine affects the expression of MFGE8 mRNA

NCBI chr 1:142,474,027...142,489,431
Ensembl chr 1:133,064,665...133,080,073

G

midline 1

affects expression

Orphenadrine affects the expression of MID1 mRNA

NCBI chr X:27,678,248...28,053,049
Ensembl chr X:24,120,293...24,248,353

G

MID1 interacting protein 1

affects expression

Orphenadrine affects the expression of MID1IP1 mRNA

NCBI chr X:14,733,539...14,735,859
Ensembl chr X:12,060,883...12,065,774

G

midnolin

affects expression

Orphenadrine affects the expression of MIDN mRNA

NCBI chr 7:10,198,761...10,210,563
Ensembl chr 7:9,549,650...9,559,752

G

MAPK interacting serine/threonine kinase 2

affects expression

Orphenadrine affects the expression of MKNK2 mRNA

NCBI chr 7:9,690,385...9,701,527
Ensembl chr 7:9,039,728...9,050,827

G

MLX interacting protein

affects expression

Orphenadrine affects the expression of MLXIP mRNA

NCBI chr12:38,789,404...38,853,059
Ensembl chr12:33,128,520...33,192,374

G

monocyte to macrophage differentiation-associated

affects expression

Orphenadrine affects the expression of MMD mRNA

NCBI chr10:75,570,366...75,598,610
Ensembl chr10:75,073,365...75,101,528

G

matrix metallopeptidase 12

affects expression

Orphenadrine affects the expression of MMP12 mRNA

NCBI chr 8:12,866,652...12,876,554
Ensembl chr 8:4,581,785...4,599,611

G

matrix metallopeptidase 15

affects expression

Orphenadrine affects the expression of MMP15 mRNA

NCBI chr19:9,669,506...9,691,000
Ensembl chr19:9,663,449...9,684,943

G

muscle RAS oncogene homolog

affects expression

Orphenadrine affects the expression of MRAS mRNA

NCBI chr 8:108,823,374...108,886,104
Ensembl chr 8:99,944,036...99,996,408

G

maestro heat-like repeat family member 2A

affects expression

Orphenadrine affects the expression of MROH2A mRNA

NCBI chr 9:96,262,307...96,309,036
Ensembl chr 9:88,814,197...88,852,607

G

macrophage stimulating 1 receptor

affects expression

Orphenadrine affects the expression of MST1R mRNA

NCBI chr 8:117,471,928...117,491,059
Ensembl chr 8:108,597,299...108,612,455

G

myotubularin related protein 7

affects expression

Orphenadrine affects the expression of MTMR7 mRNA

NCBI chr16:58,344,755...58,435,682
Ensembl chr16:51,641,190...51,732,182

G

MTSS I-BAR domain containing 2

affects expression

Orphenadrine affects the expression of MTSS2 mRNA

NCBI chr19:55,602,180...55,623,955
Ensembl chr19:38,693,194...38,713,507

G

MX dynamin like GTPase 2

affects expression

Orphenadrine affects the expression of MX2 mRNA

NCBI chr11:50,375,101...50,399,373
Ensembl chr11:36,906,111...36,930,342

G

myosin binding protein H

affects expression

Orphenadrine affects the expression of MYBPH mRNA

NCBI chr13:48,205,162...48,212,928
Ensembl chr13:45,653,234...45,660,893

G

Myb-related transcription factor, partner of profilin

affects expression

Orphenadrine affects the expression of MYPOP mRNA

NCBI chr 1:87,767,747...87,778,602
Ensembl chr 1:78,639,769...78,650,552

G

myelin regulatory factor

affects expression

Orphenadrine affects the expression of MYRF mRNA

NCBI chr 1:216,279,057...216,311,155
Ensembl chr 1:206,854,175...206,886,157

G

N-acetyltransferase 8 (GCN5-related) family member 2

affects expression

Orphenadrine affects the expression of NAT8F2 mRNA

NCBI chr 4:119,877,449...119,880,685
Ensembl chr 4:118,319,988...118,324,395

G

non-SMC condensin I complex, subunit H

affects expression

Orphenadrine affects the expression of NCAPH mRNA

NCBI chr 3:134,825,271...134,852,502
Ensembl chr 3:114,371,941...114,399,180

G

nuclear receptor coactivator 7

affects expression

Orphenadrine affects the expression of NCOA7 mRNA

NCBI chr 1:28,674,614...28,835,891
Ensembl chr 1:26,856,530...27,015,871

G

neurofilament heavy chain

affects expression

Orphenadrine affects the expression of NEFH mRNA

NCBI chr14:84,044,428...84,054,413
Ensembl chr14:79,830,362...79,840,351

G

neuralized E3 ubiquitin protein ligase 3

affects expression

Orphenadrine affects the expression of NEURL3 mRNA

NCBI chr 9:45,990,373...45,998,470
Ensembl chr 9:38,494,489...38,502,649

G

NFKB inhibitor zeta

affects expression

Orphenadrine affects the expression of NFKBIZ mRNA

NCBI chr11:58,251,720...58,279,767
Ensembl chr11:44,782,676...44,810,723

G

NHS like 3

affects expression

Orphenadrine affects the expression of NHSL3 mRNA

NCBI chr 5:146,848,747...146,877,504
Ensembl chr 5:141,564,399...141,593,176

G

ninjurin 2

affects expression

Orphenadrine affects the expression of NINJ2 mRNA

NCBI chr 4:154,978,660...155,080,860
Ensembl chr 4:153,306,553...153,408,617

G

NIPA-like domain containing 2

affects expression

Orphenadrine affects the expression of NIPAL2 mRNA

NCBI chr 7:67,659,628...67,771,105
Ensembl chr 7:65,774,477...65,884,807

G

NLR family, CARD domain containing 4

affects expression

Orphenadrine affects the expression of NLRC4 mRNA

NCBI chr 6:26,743,658...26,771,783
Ensembl chr 6:20,995,266...21,018,248

G

nocturnin

affects expression

Orphenadrine affects the expression of NOCT mRNA

NCBI chr 2:137,422,074...137,442,282
Ensembl chr 2:135,271,189...135,291,400

G

nitric oxide synthase 1 adaptor protein

affects expression

Orphenadrine affects the expression of NOS1AP mRNA

NCBI chr13:85,080,558...85,353,741
Ensembl chr13:82,530,577...82,820,949

G

nitric oxide synthase 3

affects expression

Orphenadrine affects the expression of NOS3 mRNA

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166

G

neuropeptide Y

affects expression

Orphenadrine affects the expression of NPY mRNA

NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:78,881,264...78,888,495

G

nuclear receptor subfamily 1, group D, member 1

affects expression

Orphenadrine affects the expression of NR1D1 mRNA

NCBI chr10:84,224,599...84,231,812
Ensembl chr10:83,728,318...83,735,705

G

neuronal regeneration related protein

affects expression

Orphenadrine affects the expression of NREP mRNA

NCBI chr18:25,291,219...25,320,742
Ensembl chr18:25,017,083...25,046,591

G

neuregulin 1

affects expression

Orphenadrine affects the expression of NRG1 mRNA

NCBI chr16:65,954,084...67,007,484
Ensembl chr16:59,250,854...60,296,884

G

neurexin 1

affects expression

Orphenadrine affects the expression of NRXN1 mRNA

NCBI chr 6:8,931,360...10,077,381
Ensembl chr 6:3,177,897...4,322,710

G

nuclear protein 1, transcriptional regulator

affects expression

Orphenadrine affects the expression of NUPR1 mRNA

NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:181,213,368...181,215,281

G

ornithine aminotransferase

affects expression

Orphenadrine affects the expression of OAT mRNA

NCBI chr 1:196,777,973...196,797,754
Ensembl chr 1:187,347,865...187,367,682

G

osteoglycin

affects expression

Orphenadrine affects the expression of OGN mRNA

NCBI chr17:15,238,500...15,259,167
Ensembl chr17:15,032,069...15,052,739

G

olfactory receptor 1198

affects expression

Orphenadrine affects the expression of OLR1198 mRNA

NCBI chr 8:45,764,097...45,765,026
Ensembl chr 8:37,574,531...37,576,995

G

olfactory receptor 1428

affects expression

Orphenadrine affects the expression of OLR1428 mRNA

NCBI chr10:43,447,769...43,448,716
Ensembl chr10:42,944,142...42,948,881

G

olfactory receptor 1451

affects expression

Orphenadrine affects the expression of OLR1451 mRNA

NCBI chr10:43,928,730...43,929,659
Ensembl chr10:43,424,036...43,432,210

G

osteomodulin

affects expression

Orphenadrine affects the expression of OMD mRNA

NCBI chr17:15,266,646...15,274,870
Ensembl chr17:15,060,217...15,068,441

G

olfactory receptor family 2 subfamily N member 1L

affects expression

Orphenadrine affects the expression of OR2N1L mRNA

NCBI chr20:345,864...346,802
Ensembl chr20:297,043...354,706

G

olfactory receptor family 2 subfamily Y member 1I

affects expression

Orphenadrine affects the expression of OR2Y1I mRNA

NCBI chr10:34,238,313...34,239,242
Ensembl chr10:33,732,012...33,738,729

G

oxidative stress induced growth inhibitor 1

affects expression

Orphenadrine affects the expression of OSGIN1 mRNA

NCBI chr19:64,380,336...64,409,165
Ensembl chr19:47,492,171...47,500,516

G

prolyl 3-hydroxylase 2

affects expression

Orphenadrine affects the expression of P3H2 mRNA

NCBI chr11:88,139,086...88,280,221
Ensembl chr11:74,634,267...74,775,421

G

prolyl 3-hydroxylase family member 4

affects expression

Orphenadrine affects the expression of P3H4 mRNA

NCBI chr10:85,838,528...85,845,476
Ensembl chr10:85,338,161...85,345,093

G

pannexin 2

affects expression

Orphenadrine affects the expression of PANX2 mRNA

NCBI chr 7:122,018,937...122,032,009
Ensembl chr 7:120,139,294...120,152,361

G

protocadherin 12

affects expression

Orphenadrine affects the expression of PCDH12 mRNA

NCBI chr18:30,354,910...30,370,485
Ensembl chr18:30,103,728...30,119,307

G

Purkinje cell protein 4-like 1

affects expression

Orphenadrine affects the expression of PCP4L1 mRNA

NCBI chr13:86,121,463...86,145,097
Ensembl chr13:83,588,992...83,609,966

G

proprotein convertase subtilisin/kexin type 9

affects expression

Orphenadrine affects the expression of PCSK9 mRNA

NCBI chr 5:126,440,102...126,462,507
Ensembl chr 5:121,211,278...121,233,688

G

phosphodiesterase 5A

affects expression

Orphenadrine affects the expression of PDE5A mRNA

NCBI chr 2:213,542,822...213,687,638
Ensembl chr 2:210,858,063...210,999,701

G

pyruvate dehydrogenase kinase 4

affects expression

Orphenadrine affects the expression of PDK4 mRNA

NCBI chr 4:34,558,327...34,568,329
Ensembl chr 4:33,589,799...33,601,850

G

podoplanin

affects expression

Orphenadrine affects the expression of PDPN mRNA

NCBI chr 5:160,884,995...160,919,112
Ensembl chr 5:155,601,691...155,635,656

G

period circadian regulator 2

affects expression

Orphenadrine affects the expression of PER2 mRNA

NCBI chr 9:99,454,828...99,497,069
Ensembl chr 9:92,007,296...92,049,459

G

phosphofructokinase, muscle

affects expression

Orphenadrine affects the expression of PFKM mRNA

NCBI chr 7:131,100,684...131,138,250
Ensembl chr 7:129,221,653...129,259,192

G

pleckstrin homology-like domain, family A, member 2

affects expression

Orphenadrine affects the expression of PHLDA2 mRNA

NCBI chr 1:208,126,302...208,127,241
Ensembl chr 1:198,696,897...198,697,836

G

pleckstrin homology-like domain, family A, member 3

affects expression

Orphenadrine affects the expression of PHLDA3 mRNA

NCBI chr13:49,745,003...49,748,088
Ensembl chr13:47,193,086...47,196,335

G

pleckstrin homology-like domain, family B, member 3

affects expression

Orphenadrine affects the expression of PHLDB3 mRNA

NCBI chr 1:89,328,991...89,347,446
Ensembl chr 1:80,201,578...80,219,534

G

phosphoethanolamine/phosphocholine phosphatase 1

affects expression

Orphenadrine affects the expression of PHOSPHO1 mRNA

NCBI chr10:81,258,810...81,266,345
Ensembl chr10:80,760,792...80,770,342

G

phosphatidylinositol-4-phosphate 5-kinase type 1 gamma

affects expression

Orphenadrine affects the expression of PIP5K1C mRNA

NCBI chr 7:9,048,135...9,076,751
Ensembl chr 7:8,397,406...8,425,988

G

pleckstrin homology and FYVE domain containing 2

affects expression

Orphenadrine affects the expression of PLEKHF2 mRNA

NCBI chr 5:28,888,358...28,905,350
Ensembl chr 5:24,090,688...24,106,601

G

pleckstrin homology, MyTH4 and FERM domain containing H1

affects expression

Orphenadrine affects the expression of PLEKHH1 mRNA

NCBI chr 6:103,572,304...103,621,729
Ensembl chr 6:97,839,288...97,888,709

G

perilipin 3

affects expression

Orphenadrine affects the expression of PLIN3 mRNA

NCBI chr 9:1,198,336...1,210,212
Ensembl chr 9:1,102,366...1,123,147

G

prostate transmembrane protein, androgen induced 1

affects expression

Orphenadrine affects the expression of PMEPA1 mRNA

NCBI chr 3:182,430,193...182,478,649
Ensembl chr 3:162,012,751...162,060,454

G

peripheral myelin protein 22

affects expression

Orphenadrine affects the expression of PMP22 mRNA

NCBI chr10:48,294,932...48,324,941
Ensembl chr10:47,795,709...47,825,714

G

DNA polymerase gamma 2, accessory subunit

affects expression

Orphenadrine affects the expression of POLG2 mRNA

NCBI chr10:92,212,303...92,222,849
Ensembl chr10:91,712,586...91,723,008

G

protein phosphatase, Mg2+/Mn2+ dependent, 1J

affects expression

Orphenadrine affects the expression of PPM1J mRNA

NCBI chr 2:194,966,854...194,972,228
Ensembl chr 2:192,278,517...192,283,882

G

protein phosphatase, Mg2+/Mn2+ dependent, 1K

affects expression

Orphenadrine affects the expression of PPM1K mRNA

NCBI chr 4:88,942,226...88,969,139
Ensembl chr 4:87,612,204...87,636,152

G

protein phosphatase 1, regulatory (inhibitor) subunit 1A

affects expression

Orphenadrine affects the expression of PPP1R1A mRNA

NCBI chr 7:136,533,031...136,540,687
Ensembl chr 7:134,654,579...134,662,230

G

PRELI domain containing 2

affects expression

Orphenadrine affects the expression of PRELID2 mRNA

NCBI chr18:34,120,989...34,212,699
Ensembl chr18:33,873,599...33,961,225

G

protein kinase C, eta

affects expression

Orphenadrine affects the expression of PRKCH mRNA

NCBI chr 6:98,027,830...98,226,486
Ensembl chr 6:92,292,000...92,490,654

G

prolactin receptor

affects expression

Orphenadrine affects the expression of PRLR mRNA

NCBI chr 2:60,861,391...61,051,883
Ensembl chr 2:59,134,588...59,324,718

G

proline rich protein 2

affects expression

Orphenadrine affects the expression of PRP2 mRNA

NCBI chr 4:165,600,085...165,603,662

G

proline rich and Gla domain 4

affects expression

Orphenadrine affects the expression of PRRG4 mRNA

NCBI chr 3:111,669,508...111,698,205
Ensembl chr 3:91,214,653...91,243,273

G

serine protease 53

affects expression

Orphenadrine affects the expression of PRSS53 mRNA

NCBI chr 1:191,923,398...191,931,292
Ensembl chr 1:182,494,955...182,500,115

G

protein tyrosine phosphatase, receptor type, N

affects expression

Orphenadrine affects the expression of PTPRN mRNA

NCBI chr 9:84,189,676...84,205,364
Ensembl chr 9:76,741,016...76,756,190

G

PVR cell adhesion molecule

affects expression

Orphenadrine affects the expression of PVR mRNA

NCBI chr 1:88,689,235...88,704,641
Ensembl chr 1:79,546,879...79,576,715

G

PWWP domain containing 2B

affects expression

Orphenadrine affects the expression of PWWP2B mRNA

NCBI chr 1:203,470,172...203,489,575
Ensembl chr 1:194,041,341...194,059,958

G

RAB11 family interacting protein 5

affects expression

Orphenadrine affects the expression of RAB11FIP5 mRNA

NCBI chr 4:119,428,766...119,466,277
Ensembl chr 4:117,871,308...117,908,741

G

RAB23, member RAS oncogene family

affects expression

Orphenadrine affects the expression of RAB23 mRNA

NCBI chr 9:43,440,047...43,463,327
Ensembl chr 9:35,944,085...35,966,927

G

RAB3D, member RAS oncogene family

affects expression

Orphenadrine affects the expression of RAB3D mRNA

NCBI chr 8:28,714,706...28,725,379
Ensembl chr 8:20,439,294...20,449,185

G

retinoic acid receptor, gamma

affects expression

Orphenadrine affects the expression of RARG mRNA

NCBI chr 7:135,246,427...135,268,889
Ensembl chr 7:133,367,833...133,390,177

G

Ras association domain family member 1

affects expression

Orphenadrine affects the expression of RASSF1 mRNA

NCBI chr 8:117,103,665...117,114,805
Ensembl chr 8:108,225,023...108,236,164

G

RELT-like 1

affects expression

Orphenadrine affects the expression of RELL1 mRNA

NCBI chr14:44,672,121...44,732,081
Ensembl chr14:44,303,009...44,378,500

G

renin binding protein

affects expression

Orphenadrine affects the expression of RENBP mRNA

NCBI chr X:156,812,785...156,821,860
Ensembl chr X:151,661,458...151,670,516

G

replication initiator 1

affects expression

Orphenadrine affects the expression of REPIN1 mRNA

NCBI chr 4:78,879,910...78,885,143
Ensembl chr 4:77,548,849...77,554,257

G

regulated endocrine-specific protein 18

affects expression

Orphenadrine affects the expression of RESP18 mRNA

NCBI chr 9:84,213,844...84,220,186
Ensembl chr 9:76,764,590...76,778,722

G

regulator of G-protein signaling 16

affects expression

Orphenadrine affects the expression of RGS16 mRNA

NCBI chr13:68,421,480...68,443,312
Ensembl chr13:65,887,530...65,892,857

G

rhomboid 5 homolog 2

affects expression

Orphenadrine affects the expression of RHBDF2 mRNA

NCBI chr10:102,331,991...102,359,117
Ensembl chr10:101,833,157...101,860,283

G

ras homolog family member C

affects expression

Orphenadrine affects the expression of RHOC mRNA

NCBI chr 2:194,975,586...194,981,637
Ensembl chr 2:192,287,130...192,295,306

G

ras homolog family member F, filopodia associated

affects expression

Orphenadrine affects the expression of RHOF mRNA

NCBI chr12:39,082,413...39,107,528
Ensembl chr12:33,431,280...33,446,703

G

regulator of microtubule dynamics 2

affects expression

Orphenadrine affects the expression of RMDN2 mRNA

NCBI chr 6:21,101,383...21,195,221
Ensembl chr 6:15,375,496...15,441,480

G

Rho family GTPase 1

affects expression

Orphenadrine affects the expression of RND1 mRNA

NCBI chr 7:131,700,321...131,707,392
Ensembl chr 7:129,821,311...129,828,399

G

somatomedin B and thrombospondin, type 1 domain containing

affects expression

Orphenadrine affects the expression of SBSPON mRNA

NCBI chr 5:8,186,004...8,216,576
Ensembl chr 5:3,402,648...3,435,420

G

stearoyl-CoA desaturase

affects expression

Orphenadrine affects the expression of SCD1 mRNA

NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562

G

sodium channel epithelial 1 subunit alpha

affects expression

Orphenadrine affects the expression of SCNN1A mRNA

NCBI chr 4:159,809,187...159,832,409
Ensembl chr 4:158,122,962...158,146,181

G

syndecan 3

affects expression

Orphenadrine affects the expression of SDC3 mRNA

NCBI chr 5:148,249,792...148,282,524
Ensembl chr 5:142,965,591...142,996,480

G

SEBOX homeobox

affects expression

Orphenadrine affects the expression of SEBOX mRNA

NCBI chr10:63,897,265...63,898,136
Ensembl chr10:63,399,165...63,400,606

G

serine incorporator 2

affects expression

Orphenadrine affects the expression of SERINC2 mRNA

NCBI chr 5:147,876,477...147,898,797
Ensembl chr 5:142,592,309...142,618,364

G

serpin family A member 7

affects expression

Orphenadrine affects the expression of SERPINA7 mRNA

NCBI chr X:107,452,044...107,510,958
Ensembl chr X:102,663,405...102,669,040

G

SERTA domain containing 1

affects expression

Orphenadrine affects the expression of SERTAD1 mRNA

NCBI chr 1:91,903,297...91,906,565
Ensembl chr 1:82,775,252...82,779,091

G

SET domain containing 7, histone lysine methyltransferase

affects expression

Orphenadrine affects the expression of SETD7 mRNA

NCBI chr 2:137,713,545...137,756,319
Ensembl chr 2:135,562,683...135,605,468

G

serum/glucocorticoid regulated kinase 1

affects expression

Orphenadrine affects the expression of SGK1 mRNA

NCBI chr 1:24,799,391...24,916,886
Ensembl chr 1:22,980,261...23,098,283

G

SH3 and PX domains 2B

affects expression

Orphenadrine affects the expression of SH3PXD2B mRNA

NCBI chr10:17,422,906...17,538,977
Ensembl chr10:16,918,679...17,005,170

G

SH3 and multiple ankyrin repeat domains 3

affects expression

Orphenadrine affects the expression of SHANK3 mRNA

NCBI chr 7:122,448,323...122,518,623
Ensembl chr 7:120,570,402...120,630,374

G

shisa family member 4

affects expression

Orphenadrine affects the expression of SHISA4 mRNA

NCBI chr13:49,351,518...49,355,599
Ensembl chr13:46,799,772...46,803,998

G

shroom family member 3

affects expression

Orphenadrine affects the expression of SHROOM3 mRNA

NCBI chr14:15,383,769...15,681,158
Ensembl chr14:15,099,423...15,396,915

G

SID1 transmembrane family, member 1

affects expression

Orphenadrine affects the expression of SIDT1 mRNA

NCBI chr11:69,867,758...69,965,377
Ensembl chr11:56,363,512...56,459,050

G

SIN3-HDAC complex associated factor

affects expression

Orphenadrine affects the expression of SINHCAF mRNA

NCBI chr 4:183,619,647...183,644,628
Ensembl chr 4:181,888,312...181,910,276

G

signal-induced proliferation-associated 1

affects expression

Orphenadrine affects the expression of SIPA1 mRNA

NCBI chr 1:212,367,867...212,379,952
Ensembl chr 1:202,938,580...202,950,591

G

SKI-like proto-oncogene

affects expression

Orphenadrine affects the expression of SKIL mRNA

NCBI chr 2:114,175,534...114,203,663
Ensembl chr 2:112,247,051...112,275,080

G

solute carrier family 12 member 4

affects expression

Orphenadrine affects the expression of SLC12A4 mRNA

NCBI chr19:50,748,268...50,770,217
Ensembl chr19:33,838,419...33,860,331

G

solute carrier family 16 member 10

affects expression

Orphenadrine affects the expression of SLC16A10 mRNA

NCBI chr20:45,014,229...45,122,392
Ensembl chr20:43,459,709...43,567,839

G

solute carrier family 16, member 11

affects expression

Orphenadrine affects the expression of SLC16A11 mRNA

NCBI chr10:55,427,773...55,431,678
Ensembl chr10:54,927,725...54,942,915

G

solute carrier family 16, member 14

affects expression

Orphenadrine affects the expression of SLC16A14 mRNA

NCBI chr 9:93,558,144...93,585,396
Ensembl chr 9:86,112,894...86,137,318

G

solute carrier family 16 member 5

affects expression

Orphenadrine affects the expression of SLC16A5 mRNA

NCBI chr10:101,206,371...101,220,300
Ensembl chr10:100,707,434...100,721,338

G

solute carrier family 16, member 6

affects expression

Orphenadrine affects the expression of SLC16A6 mRNA

NCBI chr10:94,923,888...94,946,990
Ensembl chr10:94,426,244...94,448,779

G

solute carrier family 1 member 4

affects expression

Orphenadrine affects the expression of SLC1A4 mRNA

NCBI chr14:98,718,646...98,761,672
Ensembl chr14:94,529,084...94,560,418

G

solute carrier family 22 member 2

multiple interactions

Orphenadrine inhibits the reaction [SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Orphenadrine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 30 member 2

affects expression

Orphenadrine affects the expression of SLC30A2 mRNA

NCBI chr 5:151,843,451...151,855,674
Ensembl chr 5:146,559,733...146,571,956

G

solute carrier family 35, member F2

affects expression

Orphenadrine affects the expression of SLC35F2 mRNA

NCBI chr 8:63,055,503...63,099,791
Ensembl chr 8:54,159,970...54,203,612

G

solute carrier family 41 member 1

affects expression

Orphenadrine affects the expression of SLC41A1 mRNA

NCBI chr13:45,822,999...45,843,364
Ensembl chr13:43,270,792...43,291,162

G

solute carrier family 6 member 8

affects expression

Orphenadrine affects the expression of SLC6A8 mRNA

NCBI chr X:156,536,017...156,545,321
Ensembl chr X:151,384,675...151,393,979

G

solute carrier family 7, member 4

affects expression

Orphenadrine affects the expression of SLC7A4 mRNA

NCBI chr11:96,939,456...96,943,127
Ensembl chr11:83,435,211...83,438,881

G

solute carrier family 9 member A7

affects expression

Orphenadrine affects the expression of SLC9A7 mRNA

NCBI chr X:4,767,578...4,948,602
Ensembl chr X:2,214,441...2,388,012

G

SMAD family member 6

affects expression

Orphenadrine affects the expression of SMAD6 mRNA

NCBI chr 8:73,345,457...73,414,985
Ensembl chr 8:64,450,114...64,519,763

G

smoothelin-like 2

affects expression

Orphenadrine affects the expression of SMTNL2 mRNA

NCBI chr10:57,506,873...57,528,050
Ensembl chr10:57,008,327...57,029,505

G

sorting nexin 10

affects expression

Orphenadrine affects the expression of SNX10 mRNA

NCBI chr 4:81,943,262...82,007,667
Ensembl chr 4:80,612,669...80,676,996

G

sortilin 1

affects expression

Orphenadrine affects the expression of SORT1 mRNA

NCBI chr 2:198,609,466...198,690,481
Ensembl chr 2:195,924,099...196,002,354

G

SRY-box transcription factor 18

affects expression

Orphenadrine affects the expression of SOX18 mRNA

NCBI chr 3:189,163,000...189,164,802
Ensembl chr 3:168,785,490...168,787,290

G

SRY-box transcription factor 4

affects expression

Orphenadrine affects the expression of SOX4 mRNA

NCBI chr17:35,876,298...35,881,004
Ensembl chr17:35,667,537...35,673,665

G

SPC25 component of NDC80 kinetochore complex

affects expression

Orphenadrine affects the expression of SPC25 mRNA

NCBI chr 3:74,337,872...74,396,825
Ensembl chr 3:53,975,704...53,988,959

G

Spetex-2C protein

affects expression

Orphenadrine affects the expression of SPETEX2C mRNA

NCBI chr15:4,779,251...4,781,549
Ensembl chr15:4,779,229...4,781,731

G

Spetex-2F protein

affects expression

Orphenadrine affects the expression of SPETEX2F mRNA

NCBI chr15:5,457,458...5,460,606
Ensembl chr15:17,716,358...17,733,744

G

Spetex-2G protein

affects expression

Orphenadrine affects the expression of SPETEX2G mRNA

NCBI chr15:5,929,946...5,933,558
Ensembl chr15:4,615,466...4,662,812

G

serine peptidase inhibitor, Kazal type 9

affects expression

Orphenadrine affects the expression of SPINK9 mRNA

NCBI chr18:36,677,935...36,681,163
Ensembl chr18:36,426,989...36,430,271

G

SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2

affects expression

Orphenadrine affects the expression of SPOCK2 mRNA

NCBI chr20:28,580,262...28,607,198
Ensembl chr20:28,033,475...28,064,272

G

SRC kinase signaling inhibitor 1

affects expression

Orphenadrine affects the expression of SRCIN1 mRNA

NCBI chr10:82,999,295...83,066,359
Ensembl chr10:82,504,393...82,571,040

G

steroid 5 alpha-reductase 1

affects expression

Orphenadrine affects the expression of SRD5A1 mRNA

NCBI chr 1:35,514,914...35,548,898
Ensembl chr 1:33,686,391...33,720,461

G

SH3 and cysteine rich domain 3

affects expression

Orphenadrine affects the expression of STAC3 mRNA

NCBI chr 7:65,227,151...65,235,884
Ensembl chr 7:63,343,186...63,350,589

G

StAR-related lipid transfer domain containing 9

affects expression

Orphenadrine affects the expression of STARD9 mRNA

NCBI chr 3:128,034,866...128,150,493
Ensembl chr 3:107,581,164...107,673,898

G

syntaxin binding protein 1

affects expression

Orphenadrine affects the expression of STXBP1 mRNA

NCBI chr 3:36,474,428...36,536,120
Ensembl chr 3:16,076,391...16,138,369

G

sulfotransferase family 1E member 1

affects expression

Orphenadrine affects the expression of SULT1E1 mRNA

NCBI chr14:20,700,444...20,718,719
Ensembl chr14:20,422,324...20,439,275

G

synapse defective Rho GTPase homolog 1

affects expression

Orphenadrine affects the expression of SYDE1 mRNA

NCBI chr 7:11,683,505...11,689,491
Ensembl chr 7:11,032,898...11,039,869

G

synaptic Ras GTPase activating protein 1

affects expression

Orphenadrine affects the expression of SYNGAP1 mRNA

NCBI chr20:5,028,226...5,058,519
Ensembl chr20:5,026,364...5,056,672

G

synaptojanin 2

affects expression

Orphenadrine affects the expression of SYNJ2 mRNA

NCBI chr 1:48,923,742...49,027,153
Ensembl chr 1:46,518,709...46,633,687

G

synemin

affects expression

Orphenadrine affects the expression of SYNM mRNA

NCBI chr 1:130,743,891...130,774,254
Ensembl chr 1:121,333,720...121,363,652

G

tubulin folding cofactor E-like

affects expression

Orphenadrine affects the expression of TBCEL mRNA

NCBI chr 8:51,692,660...51,751,560
Ensembl chr 8:42,796,730...42,854,552

G

TEA domain transcription factor 2

affects expression

Orphenadrine affects the expression of TEAD2 mRNA

NCBI chr 1:104,838,795...104,855,635
Ensembl chr 1:95,703,005...95,719,186

G

teneurin transmembrane protein 2

affects expression

Orphenadrine affects the expression of TENM2 mRNA

NCBI chr10:20,984,710...22,121,001
Ensembl chr10:20,481,854...21,705,597

G

testis expressed 13B

affects expression

Orphenadrine affects the expression of TEX13B mRNA

NCBI chr X:109,278,123...109,299,718
Ensembl chr X:104,490,091...104,494,201

G

testis expressed 36

affects expression

Orphenadrine affects the expression of TEX36 mRNA

NCBI chr 1:188,390,062...188,404,448
Ensembl chr 1:188,390,064...188,404,377

G

thioesterase superfamily member 6

affects expression

Orphenadrine affects the expression of THEM6 mRNA

NCBI chr 7:106,606,570...106,609,747
Ensembl chr 7:106,606,570...106,609,746

G

TRAF-interacting protein with forkhead-associated domain

affects expression

Orphenadrine affects the expression of TIFA mRNA

NCBI chr 2:218,927,724...218,942,111
Ensembl chr 2:216,234,774...216,267,841

G

TLC domain containing 4

affects expression

Orphenadrine affects the expression of TLCD4 mRNA

NCBI chr 2:211,969,612...212,044,883
Ensembl chr 2:209,289,732...209,341,353

G

talin rod domain containing 1

affects expression

Orphenadrine affects the expression of TLNRD1 mRNA

NCBI chr 1:147,273,475...147,275,494
Ensembl chr 1:137,864,343...137,866,359

G

transmembrane BAX inhibitor motif containing 1

affects expression

Orphenadrine affects the expression of TMBIM1 mRNA

NCBI chr 9:83,320,972...83,338,469
Ensembl chr 9:75,871,835...75,889,069

G

transmembrane protein 184B

affects expression

Orphenadrine affects the expression of TMEM184B mRNA

NCBI chr 7:112,805,512...112,848,398
Ensembl chr 7:110,925,092...110,967,943

G

transmembrane protein 184C

affects expression

Orphenadrine affects the expression of TMEM184C mRNA

NCBI chr19:47,249,403...47,265,502
Ensembl chr19:30,345,290...30,361,269

G

transmembrane protein 200B

affects expression

Orphenadrine affects the expression of TMEM200B mRNA

NCBI chr 5:144,107,795...144,110,551
Ensembl chr 5:144,103,550...144,112,506

G

TNF alpha induced protein 2

affects expression

Orphenadrine affects the expression of TNFAIP2 mRNA

NCBI chr 6:136,297,388...136,311,106
Ensembl chr 6:130,476,889...130,489,914

G

TNF receptor superfamily member 11B

affects expression

Orphenadrine affects the expression of TNFRSF11B mRNA

NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:85,566,520...85,594,538

G

TNF receptor superfamily member 12A

affects expression

Orphenadrine affects the expression of TNFRSF12A mRNA

NCBI chr10:13,211,670...13,213,666
Ensembl chr10:12,689,890...12,709,045

G

tyrosine kinase, non-receptor, 1

affects expression

Orphenadrine affects the expression of TNK1 mRNA

NCBI chr10:55,070,362...55,084,383
Ensembl chr10:54,571,117...54,579,940

G

tensin 1

affects expression

Orphenadrine affects the expression of TNS1 mRNA

NCBI chr 9:82,941,068...83,152,007
Ensembl chr 9:75,495,814...75,703,225

G

TOG array regulator of axonemal microtubules 2

affects expression

Orphenadrine affects the expression of TOGARAM2 mRNA

NCBI chr 6:29,491,183...29,549,004
Ensembl chr 6:23,771,052...23,828,499

G

TOX high mobility group box family member 3

affects expression

Orphenadrine affects the expression of TOX3 mRNA

NCBI chr19:32,820,957...32,929,776
Ensembl chr19:16,648,342...16,757,148

G

tropomyosin 1

affects expression

Orphenadrine affects the expression of TPM1 mRNA

NCBI chr 8:76,516,654...76,543,661
Ensembl chr 8:67,635,479...67,662,802

G

Tnf receptor associated factor 4

affects expression

Orphenadrine affects the expression of TRAF4 mRNA

NCBI chr10:63,552,251...63,558,356
Ensembl chr10:63,054,181...63,060,284

G

tripartite motif-containing 36

affects expression

Orphenadrine affects the expression of TRIM36 mRNA

NCBI chr18:41,047,657...41,099,497
Ensembl chr18:38,861,018...38,912,859

G

tripartite motif-containing 54

affects expression

Orphenadrine affects the expression of TRIM54 mRNA

NCBI chr 6:30,959,306...30,978,475
Ensembl chr 6:25,239,340...25,258,511

G

transient receptor potential cation channel, subfamily M, member 2

affects expression

Orphenadrine affects the expression of TRPM2 mRNA

NCBI chr20:10,703,190...10,752,795
Ensembl chr20:10,707,014...10,753,181

G

transient receptor potential cation channel, subfamily V, member 2

affects expression

Orphenadrine affects the expression of TRPV2 mRNA

NCBI chr10:47,772,223...47,797,956
Ensembl chr10:47,272,931...47,294,260

G

TSC22 domain family, member 3

affects expression

Orphenadrine affects the expression of TSC22D3 mRNA

NCBI chr X:109,006,410...109,066,389
Ensembl chr X:104,217,925...104,276,861

G

alpha tocopherol transfer protein like

affects expression

Orphenadrine affects the expression of TTPAL mRNA

NCBI chr 3:172,697,683...172,715,973
Ensembl chr 3:152,278,303...152,296,513

G

ubiquitin-like modifier activating enzyme 7

affects expression

Orphenadrine affects the expression of UBA7 mRNA

NCBI chr 8:117,543,902...117,552,709
Ensembl chr 8:108,665,292...108,674,099

G

UDP glucuronosyltransferase family 2 member A3

affects expression

Orphenadrine affects the expression of UGT2A3 mRNA

NCBI chr14:20,851,970...20,869,974
Ensembl chr14:20,572,808...20,590,729

G

UDP glucuronosyltransferase 2 family, polypeptide B1

affects expression

Orphenadrine affects the expression of UGT2B1 mRNA

NCBI chr14:21,378,882...21,390,631
Ensembl chr14:21,024,006...21,035,986

G

unc-5 netrin receptor B

affects expression

Orphenadrine affects the expression of UNC5B mRNA

NCBI chr20:29,240,639...29,307,270
Ensembl chr20:28,697,726...28,764,537

G

unk like zinc finger

affects expression

Orphenadrine affects the expression of UNKL mRNA

NCBI chr10:14,710,627...14,756,725
Ensembl chr10:14,206,189...14,252,225

G

uridine phosphorylase 2

affects expression

Orphenadrine affects the expression of UPP2 mRNA

NCBI chr 3:63,681,671...63,726,194
Ensembl chr 3:43,273,048...43,317,417

G

ubiquitin specific peptidase 18

affects expression

Orphenadrine affects the expression of USP18 mRNA

NCBI chr 4:156,143,770...156,171,292
Ensembl chr 4:154,471,592...154,499,144

G

integral membrane transport protein UST4r

affects expression

Orphenadrine affects the expression of UST4R mRNA

NCBI chr 1:214,501,347...214,571,852
Ensembl chr 1:205,072,296...205,142,691

G

vav guanine nucleotide exchange factor 2

affects expression

Orphenadrine affects the expression of VAV2 mRNA

NCBI chr 3:30,982,754...31,152,116
Ensembl chr 3:10,584,688...10,754,052

G

vasoactive intestinal peptide receptor 1

affects expression

Orphenadrine affects the expression of VIPR1 mRNA

NCBI chr 8:130,181,219...130,217,098
Ensembl chr 8:121,310,248...121,339,585

G

vanin 1

affects expression

Orphenadrine affects the expression of VNN1 mRNA

NCBI chr 1:23,356,324...23,366,629
Ensembl chr 1:21,537,094...21,547,395

G

vomeronasal 2 receptor, 3

affects expression

Orphenadrine affects the expression of VOM2R3 mRNA

NCBI chr 1:76,909...85,784
Ensembl chr 1:76,834...358,271

G

WAP four-disulfide core domain 1

affects expression

Orphenadrine affects the expression of WFDC1 mRNA

NCBI chr19:64,628,689...64,647,739
Ensembl chr19:47,720,423...47,739,108

G

WAS/WASL interacting protein family, member 3

affects expression

Orphenadrine affects the expression of WIPF3 mRNA

NCBI chr 4:84,880,403...84,960,250
Ensembl chr 4:83,550,468...83,629,386

G

X-prolyl aminopeptidase 2

affects expression

Orphenadrine affects the expression of XPNPEP2 mRNA

NCBI chr X:132,165,696...132,194,937
Ensembl chr X:127,287,979...127,317,223

G

zinc finger and BTB domain containing 10

affects expression

Orphenadrine affects the expression of ZBTB10 mRNA

NCBI chr 2:94,382,670...94,417,308
Ensembl chr 2:92,479,014...92,512,515

G

zinc finger and BTB domain containing 42

affects expression

Orphenadrine affects the expression of ZBTB42 mRNA

NCBI chr 6:137,559,622...137,561,750
Ensembl chr 6:131,738,356...131,742,685

G

zinc finger, C2HC-type containing 1A

affects expression

Orphenadrine affects the expression of ZC2HC1A mRNA

NCBI chr 2:96,194,665...96,231,957
Ensembl chr 2:94,287,354...94,324,882

G

zinc finger DHHC-type palmitoyltransferase 8

affects expression

Orphenadrine affects the expression of ZDHHC8 mRNA

NCBI chr11:96,259,383...96,273,588
Ensembl chr11:82,755,143...82,767,734

G

zinc finger protein 319

affects expression

Orphenadrine affects the expression of ZFP319 mRNA

NCBI chr19:9,708,881...9,712,860
Ensembl chr19:9,702,144...9,713,198

G

zinc finger protein 334

affects expression

Orphenadrine affects the expression of ZFP334 mRNA

NCBI chr 3:174,531,835...174,544,374
Ensembl chr 3:154,113,561...154,125,057

G

zinc finger protein 354A

affects expression

Orphenadrine affects the expression of ZFP354A mRNA

NCBI chr10:35,897,217...35,909,063
Ensembl chr10:35,396,231...35,408,068

G

zinc finger protein 36

affects expression

Orphenadrine affects the expression of ZFP36 mRNA

NCBI chr 1:92,796,628...92,799,108
Ensembl chr 1:83,669,084...83,671,564

G

zinc finger protein 36, C3H type-like 2

affects expression

Orphenadrine affects the expression of ZFP36L2 mRNA

NCBI chr 6:16,242,622...16,246,662
Ensembl chr 6:10,490,032...10,494,064

G

zinc finger protein 503

affects expression

Orphenadrine affects the expression of ZFP503 mRNA

NCBI chr15:2,362,450...2,366,238
Ensembl chr15:2,313,060...2,316,848

G

zinc finger protein 668

affects expression

Orphenadrine affects the expression of ZFP668 mRNA

NCBI chr 1:191,905,112...191,915,436
Ensembl chr 1:182,474,633...182,492,878

oxybutynin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases activity

oxybutynin results in decreased activity of ABCB11 protein

PMID:20829430 PMID:28437613

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 4

decreases activity

oxybutynin results in decreased activity of ABCB4 protein

NCBI chr 4:26,106,895...26,164,440
Ensembl chr 4:25,151,953...25,209,202

G

C-C motif chemokine ligand 2

multiple interactions

oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226

G

carboxylesterase 2H

increases hydrolysis

CES2 protein results in increased hydrolysis of oxybutynin

NCBI chr19:49,884,164...49,898,764
Ensembl chr19:32,974,242...32,988,830

G

cholinergic receptor, muscarinic 2

multiple interactions

oxybutynin binds to and results in decreased activity of CHRM2 protein

NCBI chr 4:65,981,136...66,116,128
Ensembl chr 4:65,014,144...65,149,103

G

cholinergic receptor, muscarinic 3

multiple interactions

oxybutynin binds to and results in decreased activity of CHRM3 protein

NCBI chr17:64,696,549...65,158,622
Ensembl chr17:60,005,202...60,467,278

G

cytochrome P450, family 2, subfamily c, polypeptide 79

decreases activity

oxybutynin results in decreased activity of CYP2C8 protein

G

dopamine receptor D2

affects binding

oxybutynin binds to DRD2 protein

NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:49,708,927...49,772,875

G

interleukin 1 beta

multiple interactions

oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 24

decreases expression

oxybutynin results in decreased expression of IL24 mRNA

NCBI chr13:44,905,362...44,910,760
Ensembl chr13:42,353,090...42,358,487

G

interleukin 6

multiple interactions

oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression

oxybutynin results in decreased expression of JUN mRNA

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656

G

MET proto-oncogene, receptor tyrosine kinase

decreases expression

oxybutynin results in decreased expression of MET mRNA

NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:45,790,791...45,897,876

G

matrix metallopeptidase 2

multiple interactions

oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 mRNA]; oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 protein]

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions

oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]; oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120

G

nitric oxide synthase 2

multiple interactions

oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

oxybutynin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484

G

solute carrier family 22 member 2

multiple interactions

oxybutynin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268

G

secretory leukocyte peptidase inhibitor

increases expression

oxybutynin results in increased expression of SLPI mRNA

NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:153,082,369...153,084,453

G

toll-like receptor 4

multiple interactions

oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

multiple interactions

oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

pancuronium

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

decreases activity

Pancuronium results in decreased activity of ACHE protein

PMID:24157926 PMID:25522658

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651

G

cholinergic receptor, muscarinic 1

multiple interactions

Pancuronium inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]

NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:205,567,220...205,582,356

G

cholinergic receptor, muscarinic 2

multiple interactions

Pancuronium inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]

NCBI chr 4:65,981,136...66,116,128
Ensembl chr 4:65,014,144...65,149,103

G

cholinergic receptor, muscarinic 3

multiple interactions

Pancuronium inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]

NCBI chr17:64,696,549...65,158,622
Ensembl chr17:60,005,202...60,467,278

G

cholinergic receptor, muscarinic 4

multiple interactions

Pancuronium inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein]

NCBI chr 3:98,349,080...98,356,821
Ensembl chr 3:77,893,425...77,901,159

G

cholinergic receptor, muscarinic 5

multiple interactions

Pancuronium inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]

NCBI chr 3:119,739,229...119,791,630
Ensembl chr 3:99,284,846...99,337,252

G

cholinergic receptor nicotinic alpha 3 subunit

multiple interactions

Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]

NCBI chr 8:64,297,755...64,311,251
Ensembl chr 8:55,401,702...55,415,165

G

cholinergic receptor nicotinic alpha 4 subunit

multiple interactions

Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Pancuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Pancuronium results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]

PMID:14645658 PMID:16931985

NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:168,136,266...168,156,957

G

cholinergic receptor nicotinic alpha 7 subunit

multiple interactions

Pancuronium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]

NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Pancuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Pancuronium results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]

PMID:14645658 PMID:16931985

NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:175,181,402...175,189,619

G

cholinergic receptor nicotinic beta 4 subunit

multiple interactions

Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]

NCBI chr 8:64,312,644...64,333,319
Ensembl chr 8:55,418,313...55,437,027

papaverine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin converting enzyme 2

decreases expression

Papaverine results in decreased expression of ACE2 mRNA

NCBI chr X:33,925,458...33,972,851
Ensembl chr X:30,293,589...30,340,977

G

brain-derived neurotrophic factor

increases expression

Papaverine results in increased expression of BDNF mRNA

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615

G

CF transmembrane conductance regulator

multiple interactions
increases activity

Papaverine promotes the reaction [CFTR protein affects the secretion of Chlorides]
Papaverine results in increased activity of CFTR protein

NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:46,560,885...46,728,756

G

claudin 5

decreases expression

Papaverine results in decreased expression of CLDN5 protein

NCBI chr11:95,717,172...95,718,598
Ensembl chr11:82,211,475...82,214,992

G

cAMP responsive element binding protein 1

increases expression

Papaverine results in increased expression of CREB1 mRNA

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

Papaverine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

Papaverine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312

G

hepcidin antimicrobial peptide

decreases expression

Papaverine results in decreased expression of HAMP mRNA

NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:86,170,901...86,172,891

G

heat shock transcription factor 1

increases activity

Papaverine results in increased activity of HSF1 protein

NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:108,196,056...108,223,011

G

lipase E, hormone sensitive type

multiple interactions

Papaverine inhibits the reaction [Isoproterenol affects the localization of LIPE protein]; Papaverine inhibits the reaction [Isoproterenol results in increased activity of LIPE protein]

NCBI chr 1:90,093,433...90,112,117
Ensembl chr 1:80,965,627...80,984,310

G

nuclear receptor subfamily 1, group H, member 4

increases activity

Papaverine results in increased activity of NR1H4 protein

NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:23,846,122...23,942,047

G

neurotrophic receptor tyrosine kinase 2

increases expression

Papaverine results in increased expression of NTRK2 mRNA

NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,559,043...5,869,136

G

occludin

decreases expression

Papaverine results in decreased expression of OCLN protein

NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:31,657,220...31,764,150

G

phosphodiesterase 7A

multiple interactions

Papaverine inhibits the reaction [PDE7A protein results in increased hydrolysis of Cyclic AMP]

NCBI chr 2:103,631,655...103,723,057
Ensembl chr 2:101,718,444...101,806,681

G

phosphodiesterase 7B

multiple interactions

Papaverine inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP]

NCBI chr 1:16,994,072...17,312,828
Ensembl chr 1:15,182,704...15,492,900

G

solute carrier family 22 member 3

multiple interactions

Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]

PMID:9830022 PMID:12411423

NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:48,235,476...48,324,612

pethidine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

carboxylesterase 1D

affects binding
increases hydrolysis

Meperidine binds to CES1 protein
CES1 protein results in increased hydrolysis of Meperidine

NCBI chr19:30,046,494...30,085,039
Ensembl chr19:13,796,623...13,912,035

G

carboxylesterase 2H

affects binding

Meperidine binds to CES2 protein

NCBI chr19:49,884,164...49,898,764
Ensembl chr19:32,974,242...32,988,830

pirenzepine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

arginine vasopressin receptor 1A

multiple interactions

Pirenzepine binds to and results in decreased activity of AVPR1A protein

NCBI chr 7:59,999,743...60,003,667
Ensembl chr 7:58,114,284...58,122,215

G

CD40 molecule

multiple interactions

Pirenzepine inhibits the reaction [Carbachol results in increased expression of CD40 protein]

NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:153,790,449...153,805,534

G

cholinergic receptor, muscarinic 1

multiple interactions
affects binding

brucine affects the reaction [Pirenzepine analog binds to CHRM1 protein]; Pirenzepine inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]; Pirenzepine inhibits the reaction [Scopolamine Derivatives binds to CHRM1 protein]
Pirenzepine binds to and results in decreased activity of CHRM1 protein; Pirenzepine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]

PMID:8032910 PMID:9846649 PMID:11306684 PMID:12646291 PMID:15294002 More...

NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:205,567,220...205,582,356

G

cholinergic receptor, muscarinic 5

multiple interactions

Pirenzepine inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]

NCBI chr 3:119,739,229...119,791,630
Ensembl chr 3:99,284,846...99,337,252

G

early growth response 1

multiple interactions

Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA]

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766

G

early growth response 2

multiple interactions

Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA]

NCBI chr20:21,050,149...21,055,201
Ensembl chr20:21,051,277...21,055,562

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036

G

JunB proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA]

NCBI chr19:40,081,126...40,082,910
Ensembl chr19:23,176,294...23,178,035

pridinol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

pridinol results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008

G

solute carrier family 22 member 2

multiple interactions

pridinol inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268

quinine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

affects uptake

ABCB1 protein affects the uptake of Quinine analog

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

affects uptake

ABCB1B protein affects the uptake of Quinine analog

NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:25,242,798...25,325,199

G

amyloid beta precursor protein

multiple interactions

Quinine affects the reaction [APP protein binds to APP protein]

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases activity
decreases activity
increases expression

Quinine results in increased activity of CYP1A1 protein
Quinine results in decreased activity of CYP1A1 protein
Quinine results in increased expression of CYP1A1 mRNA

PMID:12451431 PMID:33814510

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases expression

Quinine results in increased expression of CYP1A2 mRNA

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, subfamily 2, polypeptide 11

decreases activity

Quinine results in decreased activity of CYP2C11 protein

PMID:12814958 PMID:15879494

NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases activity

Quinine results in decreased activity of CYP2C6 protein
Quinine results in decreased activity of CYP2C19 protein

PMID:11124226 PMID:12814958 PMID:15879494

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily d, polypeptide 2

decreases activity
multiple interactions

Quinine results in decreased activity of CYP2D2 protein
Quinine inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin]

PMID:12814958 PMID:19858067

NCBI chr 7:115,815,212...115,819,281
Ensembl chr 7:113,935,138...113,939,209

G

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions

Quinine inhibits the reaction [CYP2D6 protein results in increased oxidation of Chlorpyrifos]

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity
affects metabolic processing

Quinine results in decreased activity of CYP3A4 protein
CYP3A4 protein affects the metabolism of Quinine

PMID:11124226 PMID:12920490 PMID:15896247

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008

G

glutamate metabotropic receptor 1

affects response to substance

GRM1 protein affects the susceptibility to Quinine

NCBI chr 1:6,878,542...7,273,447
Ensembl chr 1:5,058,292...5,453,170

G

glutathione S-transferase mu 1

decreases activity

Quinine results in decreased activity of GSTM1 protein

NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase pi 1

multiple interactions
decreases activity

Quinine inhibits the reaction [GSTP1 protein affects the metabolism of and results in decreased activity of Ethacrynic Acid]
Quinine results in decreased activity of GSTP1 protein

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226

G

interleukin 1 alpha

multiple interactions

[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Quinine

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 6

multiple interactions

[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Quinine

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

potassium voltage-gated channel subfamily H member 2

affects response to substance
decreases activity

KCNH2 gene SNP affects the susceptibility to Quinine
Quinine results in decreased activity of KCNH2 protein

PMID:12695533 PMID:28551711

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008

G

potassium two pore domain channel subfamily K member 18

multiple interactions

Quinine inhibits the reaction [KCNK18 protein results in increased transport of Potassium]

NCBI chr 1:268,360,738...268,375,012
Ensembl chr 1:258,374,671...258,388,945

G

solute carrier family 22 member 1

multiple interactions
increases uptake
decreases activity

Quinine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
SLC22A1 protein results in increased uptake of Quinine
[Quinine results in decreased activity of SLC22A1] which results in decreased uptake of abacavir; Quinine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Quinine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Quinine inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]
Quinine results in decreased activity of SLC22A1; Quinine results in decreased activity of SLC22A1 protein

PMID:16142924 PMID:16263091 PMID:19357179 PMID:25844889 PMID:27504015 More...

NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:48,076,666...48,103,678

G

solute carrier family 22 member 2

multiple interactions
decreases activity

Quinine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Quinine inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Quinine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Quinine inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]
Quinine results in decreased activity of SLC22A2 protein

PMID:16263091 PMID:19357179 PMID:21599003 PMID:27504015 PMID:31830554

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 22 member 3

multiple interactions

Quinine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Quinine inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]

PMID:16263091 PMID:19357179

NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:48,235,476...48,324,612

G

solute carrier family 47 member 1

multiple interactions

Quinine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,034,122...46,087,637

G

solute carrier family 47 member 2

multiple interactions

Quinine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,490,262...46,532,954
Ensembl chr10:45,991,095...46,033,904

G

solute carrier family 9 member A7

decreases activity

Quinine results in decreased activity of SLC9A7 protein

NCBI chr X:4,767,578...4,948,602
Ensembl chr X:2,214,441...2,388,012

G

solute carrier organic anion transporter family, member 1a4

decreases activity
increases uptake
multiple interactions

Quinine results in decreased activity of SLCO1A4 protein
SLCO1A2 protein results in increased uptake of Quinine
naringin inhibits the reaction [SLCO1A2 protein results in increased uptake of Quinine]; Quinine inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]
Quinine inhibits the reaction [SLCO1A4 protein results in increased uptake of Digoxin]

PMID:11883641 PMID:27504015

NCBI chr 4:176,441,104...176,495,846
Ensembl chr 4:174,710,004...175,254,573

G

tumor necrosis factor

multiple interactions

[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Quinine
Quinine inhibits the reaction [TNF protein results in increased transport of Potassium]

PMID:10783394 PMID:19362101

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

rocuronium

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cholinergic receptor, muscarinic 1

multiple interactions

rocuronium inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]

NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:205,567,220...205,582,356

G

cholinergic receptor, muscarinic 2

multiple interactions

rocuronium inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]

NCBI chr 4:65,981,136...66,116,128
Ensembl chr 4:65,014,144...65,149,103

G

cholinergic receptor, muscarinic 3

multiple interactions

rocuronium inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]

NCBI chr17:64,696,549...65,158,622
Ensembl chr17:60,005,202...60,467,278

G

cholinergic receptor, muscarinic 4

multiple interactions

rocuronium inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein]

NCBI chr 3:98,349,080...98,356,821
Ensembl chr 3:77,893,425...77,901,159

G

cholinergic receptor, muscarinic 5

multiple interactions

rocuronium inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]

NCBI chr 3:119,739,229...119,791,630
Ensembl chr 3:99,284,846...99,337,252

G

cholinergic receptor nicotinic alpha 3 subunit

multiple interactions

rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]

NCBI chr 8:64,297,755...64,311,251
Ensembl chr 8:55,401,702...55,415,165

G

cholinergic receptor nicotinic alpha 4 subunit

multiple interactions

rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]

NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:168,136,266...168,156,957

G

cholinergic receptor nicotinic alpha 7 subunit

multiple interactions

rocuronium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]

NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]

NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:175,181,402...175,189,619

G

cholinergic receptor nicotinic beta 4 subunit

multiple interactions

rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]

NCBI chr 8:64,312,644...64,333,319
Ensembl chr 8:55,418,313...55,437,027

scopolamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

decreases expression

Scopolamine results in decreased expression of ABCB1 mRNA

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily G member 1

increases expression

Scopolamine results in increased expression of ABCG1 mRNA

NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,126,687...9,182,948

G

acetylcholinesterase

multiple interactions
increases expression
affects activity
increases activity
decreases activity
decreases expression
affects response to substance
increases response to substance

kangshuai yizhi inhibits the reaction [Scopolamine results in increased activity of ACHE protein]
Scopolamine results in increased expression of ACHE mRNA; Scopolamine results in increased expression of ACHE protein
Scopolamine affects the activity of ACHE protein
Scopolamine results in decreased activity of ACHE protein
Ascorbic Acid inhibits the reaction [Scopolamine results in decreased activity of ACHE protein]; Canagliflozin inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Galantamine inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; stevioside inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Vitamin E inhibits the reaction [Scopolamine results in decreased activity of ACHE protein]
Scopolamine results in decreased expression of ACHE protein
7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in increased expression of ACHE protein]; acanthoside B inhibits the reaction [Scopolamine results in increased expression of ACHE protein]; ajoene inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; chong-myung-tang inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; dihydroactinidiolide inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Donepezil inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; mangiferin inhibits the reaction [Scopolamine results in decreased expression of ACHE protein]; Piracetam inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Plant Extracts affects the reaction [Scopolamine affects the activity of ACHE protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased expression of ACHE mRNA]; polygalacic acid inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; protopanaxadiol inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Serotonin analog inhibits the reaction [Scopolamine results in increased activity of ACHE protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of ACHE protein]
ACHE affects the susceptibility to Scopolamine
ACHE protein results in increased susceptibility to Scopolamine

PMID:11814146 PMID:15301936 PMID:18533140 PMID:18672024 PMID:20673844 More...

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651

G

adenosine A3 receptor

multiple interactions

[N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein] which results in decreased susceptibility to Scopolamine

NCBI chr 2:196,077,042...196,080,686
Ensembl chr 2:193,388,713...193,392,357

G

angiotensinogen

multiple interactions

[AGT protein modified form binds to and results in decreased activity of LNPEP protein] which results in decreased susceptibility to Scopolamine

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977

G

AKT serine/threonine kinase 1

decreases phosphorylation

Scopolamine results in decreased phosphorylation of AKT1 protein

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

amyloid beta precursor protein binding family A member 1

increases expression

Scopolamine results in increased expression of APBA1 mRNA

NCBI chr 1:230,790,297...230,995,986
Ensembl chr 1:221,363,778...221,566,553

G

amyloid beta precursor like protein 2

increases expression

Scopolamine results in increased expression of APLP2 mRNA

NCBI chr 8:37,857,407...37,920,487
Ensembl chr 8:29,599,230...29,661,855

G

amyloid beta precursor protein

decreases cleavage

Scopolamine results in decreased cleavage of APP protein

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561

G

activity-regulated cytoskeleton-associated protein

decreases expression
decreases expression

Scopolamine results in decreased expression of ARC mRNA
scopolamine decreases expression of Arc mRNA and protein in cerebral cortex and hippocampus

CTD
RGD

PMID:17540011 PMID:24012642

NCBI chr 7:108,444,959...108,448,413
Ensembl chr 7:106,555,785...106,559,378

G

arginase 2

decreases expression

Scopolamine results in decreased expression of ARG2 mRNA

NCBI chr 6:103,669,001...103,694,375
Ensembl chr 6:97,936,002...97,961,378

G

ARF like GTPase 4D

decreases expression

Scopolamine results in decreased expression of ARL4D mRNA

NCBI chr10:87,092,276...87,103,079
Ensembl chr10:86,595,661...86,602,836

G

arginine vasopressin

multiple interactions

[[[AVP binds to and results in increased activity of AVPR1A protein] which results in increased abundance of Calcium] which results in increased activity of CHRM1 protein] which results in decreased susceptibility to Scopolamine

NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:117,793,457...117,795,425

G

arginine vasopressin receptor 1A

multiple interactions

[[[AVP binds to and results in increased activity of AVPR1A protein] which results in increased abundance of Calcium] which results in increased activity of CHRM1 protein] which results in decreased susceptibility to Scopolamine

NCBI chr 7:59,999,743...60,003,667
Ensembl chr 7:58,114,284...58,122,215

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

Scopolamine results in increased expression of BAX mRNA; Scopolamine results in increased expression of BAX protein
Galantamine inhibits the reaction [Scopolamine results in increased expression of BAX protein]; intybin inhibits the reaction [Scopolamine results in increased expression of BAX protein]
dihydroactinidiolide inhibits the reaction [Scopolamine results in increased expression of BAX protein]; Donepezil inhibits the reaction [Scopolamine results in increased expression of BAX protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased expression of BAX mRNA]

PMID:17120751 PMID:26434561 PMID:27346436 PMID:34371027

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

branched chain amino acid transaminase 1

increases expression

Scopolamine results in increased expression of BCAT1 mRNA

NCBI chr 4:179,695,662...179,777,973
Ensembl chr 4:177,964,834...178,046,597

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

Scopolamine results in decreased expression of BCL2 mRNA; Scopolamine results in decreased expression of BCL2 protein
Galantamine inhibits the reaction [Scopolamine results in decreased expression of BCL2 protein]; intybin inhibits the reaction [Scopolamine results in decreased expression of BCL2 protein]
dihydroactinidiolide inhibits the reaction [Scopolamine results in decreased expression of BCL2 protein]; Donepezil inhibits the reaction [Scopolamine results in decreased expression of BCL2 protein]

PMID:17120751 PMID:26434561 PMID:27346436 PMID:34371027

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

brain-derived neurotrophic factor

multiple interactions
decreases expression

Scopolamine inhibits the reaction [Dizocilpine Maleate affects the expression of BDNF mRNA]; Scopolamine inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA]
Scopolamine results in decreased expression of BDNF mRNA; Scopolamine results in decreased expression of BDNF protein
[acanthoside B co-treated with Scopolamine] results in increased expression of BDNF protein; [Tacrine co-treated with Scopolamine] results in increased expression of BDNF protein; Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of BDNF mRNA]; Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]; dihydroactinidiolide inhibits the reaction [Scopolamine results in decreased expression of BDNF mRNA]; Donepezil inhibits the reaction [Scopolamine results in decreased expression of BDNF mRNA]; Melatonin inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]; Plant Extracts inhibits the reaction [Scopolamine results in decreased expression of BDNF mRNA]; Serotonin analog inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]; Tacrine inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]

PMID:8405262 PMID:8635431 PMID:22096544 PMID:26408985 PMID:26434561 More...

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615

G

calcium voltage-gated channel subunit alpha1 D

increases expression

Scopolamine results in increased expression of CACNA1D mRNA

NCBI chr16:5,233,682...5,527,549
Ensembl chr16:5,228,306...5,668,215

G

calcium/calmodulin-dependent protein kinase kinase 2

decreases expression

Scopolamine results in decreased expression of CAMKK2 mRNA

NCBI chr12:39,451,828...39,505,719
Ensembl chr12:33,791,052...33,843,279

G

CART prepropeptide

decreases expression

Scopolamine results in decreased expression of CARTPT mRNA

NCBI chr 2:32,989,215...32,991,794
Ensembl chr 2:31,255,098...31,290,713

G

caspase 3

increases expression
increases cleavage
multiple interactions
increases activity

Scopolamine results in increased expression of CASP3 mRNA; Scopolamine results in increased expression of CASP3 protein
Scopolamine results in increased cleavage of CASP3 protein
Galantamine inhibits the reaction [Scopolamine results in increased cleavage of CASP3 protein]; intybin inhibits the reaction [Scopolamine results in increased cleavage of CASP3 protein]
Scopolamine results in increased activity of CASP3 protein
dihydroactinidiolide inhibits the reaction [Scopolamine results in increased activity of CASP3 protein]; Donepezil inhibits the reaction [Scopolamine results in increased activity of CASP3 protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased expression of CASP3 mRNA]

PMID:17120751 PMID:26434561 PMID:27346436 PMID:34371027

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions
decreases activity
increases activity

acanthoside B inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; chong-myung-tang inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; dihydroactinidiolide inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; Donepezil inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; Piracetam inhibits the reaction [Scopolamine results in increased activity of CAT protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased activity of CAT protein]; Tacrine inhibits the reaction [Scopolamine results in decreased activity of CAT protein]
Galantamine inhibits the reaction [Scopolamine results in decreased activity of CAT protein]; intybin inhibits the reaction [Scopolamine results in decreased activity of CAT protein]

PMID:20673844 PMID:27346436 PMID:27717698 PMID:31077737 PMID:34371027

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478

G

CD3 epsilon subunit of T-cell receptor complex

decreases expression

Scopolamine results in decreased expression of CD3E mRNA

NCBI chr 8:54,200,617...54,211,770
Ensembl chr 8:45,303,852...45,315,022

G

cyclin-dependent kinase-like 4

increases expression

Scopolamine results in increased expression of CDKL4 mRNA

NCBI chr 6:20,202,047...20,244,821
Ensembl chr 6:14,450,681...14,492,046

G

choline O-acetyltransferase

decreases activity
multiple interactions

Scopolamine results in decreased activity of CHAT protein
protopanaxadiol inhibits the reaction [Scopolamine results in decreased activity of CHAT protein]; Serotonin analog inhibits the reaction [Scopolamine results in decreased activity of CHAT protein]
kangshuai yizhi inhibits the reaction [Scopolamine results in decreased activity of CHAT protein]

PMID:20694781 PMID:26408985 PMID:29133030

NCBI chr16:7,663,665...7,723,416
Ensembl chr16:7,657,362...7,717,093

G

cholinergic receptor, muscarinic 1

multiple interactions
decreases expression
increases expression

[[[AVP binds to and results in increased activity of AVPR1A protein] which results in increased abundance of Calcium] which results in increased activity of CHRM1 protein] which results in decreased susceptibility to Scopolamine; Canagliflozin affects the reaction [Scopolamine results in decreased expression of CHRM1 protein]
Scopolamine results in increased expression of CHRM1 mRNA
7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in decreased expression of CHRM1 protein]; Plant Extracts inhibits the reaction [Scopolamine results in increased expression of CHRM1 mRNA]

PMID:11553362 PMID:26434561 PMID:28837785 PMID:32001261

NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:205,567,220...205,582,356

G

cholinergic receptor, muscarinic 4

increases response to substance

CHRM4 protein results in increased susceptibility to Scopolamine

NCBI chr 3:98,349,080...98,356,821
Ensembl chr 3:77,893,425...77,901,159

G

cholinergic receptor, muscarinic 5

decreases response to substance

CHRM5 protein results in decreased susceptibility to Scopolamine

NCBI chr 3:119,739,229...119,791,630
Ensembl chr 3:99,284,846...99,337,252

G

cholinergic receptor nicotinic alpha 4 subunit

affects binding
multiple interactions

Scopolamine binds to [CHRNA4 protein binds to CHRNB2 protein]
Scopolamine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]

NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:168,136,266...168,156,957

G

cholinergic receptor nicotinic beta 2 subunit

affects binding
multiple interactions

Scopolamine binds to [CHRNA4 protein binds to CHRNB2 protein]
Scopolamine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]

NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:175,181,402...175,189,619

G

cochlin

decreases expression

Scopolamine results in decreased expression of COCH mRNA

NCBI chr 6:74,766,485...74,780,504
Ensembl chr 6:69,031,167...69,045,109

G

coronin 1B

increases expression

Scopolamine results in increased expression of CORO1B mRNA

NCBI chr 1:210,872,437...210,877,876
Ensembl chr 1:201,443,014...201,448,416

G

cytochrome c oxidase subunit 5B

increases expression

Scopolamine results in increased expression of COX5B mRNA

NCBI chr 9:46,417,735...46,419,664
Ensembl chr 9:38,921,967...38,925,052

G

cAMP responsive element binding protein 1

decreases phosphorylation
multiple interactions

Scopolamine results in decreased phosphorylation of CREB1 protein
acanthoside B inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein]; Serotonin analog inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein]; Tacrine inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein]

PMID:26408985 PMID:31077737

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816

G

crystallin, alpha B

increases expression

Scopolamine results in increased expression of CRYAB mRNA

NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:51,093,441...51,099,157

G

colony stimulating factor 2

multiple interactions
decreases response to substance

IL1RN protein inhibits the reaction [CSF2 protein results in decreased susceptibility to Scopolamine]

NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,386,945...38,389,199

G

C-X-C motif chemokine receptor 5

decreases expression

Scopolamine results in decreased expression of CXCR5 mRNA

NCBI chr 8:53,738,878...53,756,813
Ensembl chr 8:44,843,413...44,857,893

G

dopa decarboxylase

decreases expression

Scopolamine results in decreased expression of DDC mRNA

NCBI chr14:90,592,304...90,682,830
Ensembl chr14:86,378,685...86,469,208

G

deoxyguanosine kinase

increases expression

Scopolamine results in increased expression of DGUOK mRNA

NCBI chr 4:117,544,784...117,572,414
Ensembl chr 4:115,979,094...116,014,733

G

iodothyronine deiodinase 2

increases expression

Scopolamine results in increased expression of DIO2 mRNA

NCBI chr 6:115,396,308...115,410,594
Ensembl chr 6:109,665,523...109,679,809

G

dual specificity phosphatase 5

decreases expression

Scopolamine results in decreased expression of DUSP5 mRNA

NCBI chr 1:262,543,774...262,557,201
Ensembl chr 1:252,538,449...252,551,818

G

dual specificity phosphatase 6

decreases expression

Scopolamine results in decreased expression of DUSP6 mRNA

NCBI chr 7:35,979,502...35,983,834
Ensembl chr 7:34,092,943...34,097,185

G

epidermal growth factor receptor

decreases expression

Scopolamine results in decreased expression of EGFR mRNA

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382

G

early growth response 1

multiple interactions
decreases expression

[Scopolamine co-treated with 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine] results in increased expression of EGR1 mRNA; Scopolamine affects the reaction [SK&F 82958 results in increased expression of EGR1 mRNA]
Donepezil inhibits the reaction [Scopolamine results in decreased expression of EGR1 protein]; protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of EGR1 protein]
Scopolamine results in decreased expression of EGR1 mRNA

PMID:8861055 PMID:17540011 PMID:29133030

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766

G

early growth response 2

decreases expression

Scopolamine results in decreased expression of EGR2 mRNA

NCBI chr20:21,050,149...21,055,201
Ensembl chr20:21,051,277...21,055,562

G

eukaryotic translation initiation factor 2 subunit alpha

increases expression

Scopolamine results in increased expression of EIF2S1 mRNA

NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:97,672,766...97,706,225

G

EMAP like 1

decreases expression

Scopolamine results in decreased expression of EML1 mRNA

NCBI chr 6:133,048,271...133,221,642
Ensembl chr 6:127,284,029...127,457,246

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
decreases expression
increases expression

[Scopolamine co-treated with 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine] results in increased expression of FOS mRNA; Physostigmine inhibits the reaction [Scopolamine promotes the reaction [SK&F 82958 results in increased expression of FOS mRNA]]; Ro4368554 inhibits the reaction [Scopolamine results in increased expression of FOS protein]; Scopolamine affects the reaction [SK&F 82958 results in increased expression of FOS mRNA]; Scopolamine inhibits the reaction [Haloperidol results in increased expression of FOS protein]; Scopolamine promotes the reaction [SK&F 82958 results in increased expression of FOS mRNA]
Donepezil inhibits the reaction [Scopolamine results in decreased expression of FOS protein]; protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of FOS protein]
Scopolamine results in decreased expression of FOS mRNA

PMID:1393566 PMID:8281324 PMID:8861055 PMID:11337201 PMID:17540011 More...

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036

G

gamma-aminobutyric acid type B receptor subunit 1

increases expression

Scopolamine results in increased expression of GABBR1 mRNA

NCBI chr20:1,469,779...1,499,352
Ensembl chr20:1,464,534...1,493,994

G

growth associated protein 43

decreases expression
multiple interactions

Scopolamine results in decreased expression of GAP43 protein
Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of GAP43 protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of GAP43 protein]

NCBI chr11:71,882,131...71,975,799
Ensembl chr11:58,376,371...58,470,045

G

glial fibrillary acidic protein

multiple interactions
decreases expression

Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of GFAP mRNA]; Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of GFAP protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of GFAP protein]
Scopolamine results in decreased expression of GFAP mRNA; Scopolamine results in decreased expression of GFAP protein

NCBI chr10:88,352,987...88,361,661
Ensembl chr10:87,852,890...87,861,589

G

gap junction protein, beta 2

increases expression

Scopolamine results in increased expression of GJB2 mRNA

NCBI chr15:35,375,977...35,393,817
Ensembl chr15:31,260,357...31,278,177

G

glypican 3

decreases expression

Scopolamine results in decreased expression of GPC3 mRNA

NCBI chr X:136,789,770...137,157,598
Ensembl chr X:131,868,990...132,236,798

G

glutamate metabotropic receptor 4

multiple interactions

Scopolamine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]

NCBI chr20:5,486,024...5,574,668
Ensembl chr20:5,481,124...5,572,821

G

glutathione-disulfide reductase

decreases activity
multiple interactions

Scopolamine results in decreased activity of GSR protein
Serotonin analog inhibits the reaction [Scopolamine results in decreased activity of GSR protein]; Tacrine inhibits the reaction [Scopolamine results in decreased activity of GSR protein]

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661

G

glycophorin C

decreases expression

Scopolamine results in decreased expression of GYPC mRNA

NCBI chr18:24,434,921...24,467,592
Ensembl chr18:24,160,739...24,193,204

G

heme oxygenase 1

multiple interactions
increases expression

7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in increased expression of HMOX1 protein]

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079

G

homer scaffold protein 1

decreases expression

Scopolamine results in decreased expression of HOMER1 mRNA

NCBI chr 2:26,279,012...26,388,279
Ensembl chr 2:24,543,093...24,644,785

G

histamine receptor H 1

multiple interactions

[Histamine binds to and results in increased activity of HRH1 protein] which results in decreased susceptibility to Scopolamine; Pyrilamine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in decreased susceptibility to Scopolamine]

NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:147,645,995...147,647,455

G

histamine receptor H 2

multiple interactions

[[thioperamide results in increased abundance of Histamine] which results in increased activity of HRH2 protein] which results in decreased susceptibility to Scopolamine; Cimetidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in decreased susceptibility to Scopolamine]

PMID:11640976 PMID:19215234

NCBI chr17:10,371,083...10,412,979
Ensembl chr17:10,368,298...10,407,631

G

histamine receptor H3

multiple interactions

[clobenpropit binds to and results in decreased activity of HRH3 protein] which results in decreased susceptibility to Scopolamine

NCBI chr 3:187,569,174...187,575,263
Ensembl chr 3:167,191,558...167,196,642

G

heat shock protein family A (Hsp70) member 2

increases expression

Scopolamine results in increased expression of HSPA2 mRNA

NCBI chr 6:100,864,172...100,866,946
Ensembl chr 6:95,128,350...95,131,287

G

5-hydroxytryptamine receptor 1A

multiple interactions
increases expression

[4-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine binds to and results in increased activity of HTR1A] which results in decreased susceptibility to Scopolamine; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [[4-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine binds to and results in increased activity of HTR1A] which results in decreased susceptibility to Scopolamine]
Scopolamine increases expression of Htr1a mRNA in amygdala, hippocampal formation; Scopolamine increases expression of Htr1a protein in amygdala, hippocampal formation

CTD
RGD

PMID:10578133 PMID:27760517

NCBI chr 2:38,427,169...38,431,733
Ensembl chr 2:36,694,174...36,695,442

G

5-hydroxytryptamine receptor 2C

increases expression

Scopolamine results in increased expression of HTR2C mRNA

NCBI chr X:115,453,190...115,682,325
Ensembl chr X:110,641,153...110,870,287

G

5-hydroxytryptamine receptor 6

decreases expression

Scopolamine results in decreased expression of HTR6 mRNA

NCBI chr 5:156,579,901...156,595,147
Ensembl chr 5:151,296,662...151,311,912

G

interferon gamma

multiple interactions
increases expression

Fatty Acids, Unsaturated deficiency promotes the reaction [Scopolamine results in increased expression of IFNG mRNA]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 10

decreases expression
multiple interactions

Scopolamine results in decreased expression of IL10 protein
acanthoside B inhibits the reaction [Scopolamine results in decreased expression of IL10 protein]; polygalacic acid inhibits the reaction [Scopolamine results in decreased expression of IL10 protein]; Tacrine inhibits the reaction [Scopolamine results in decreased expression of IL10 protein]

PMID:26926176 PMID:31077737

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 alpha

decreases response to substance

IL1A protein results in decreased susceptibility to Scopolamine

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

increases expression
multiple interactions

Scopolamine results in increased expression of IL1B mRNA; Scopolamine results in increased expression of IL1B protein
Fatty Acids, Unsaturated deficiency promotes the reaction [Scopolamine results in increased expression of IL1B mRNA]
acanthoside B inhibits the reaction [Scopolamine results in increased expression of IL1B protein]; polygalacic acid inhibits the reaction [Scopolamine results in increased expression of IL1B protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of IL1B protein]; timosaponin AIII inhibits the reaction [Scopolamine results in increased expression of IL1B protein]

PMID:18357464 PMID:19426756 PMID:21161262 PMID:26926176 PMID:31077737

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor antagonist

multiple interactions

IL1RN protein inhibits the reaction [CSF2 protein results in decreased susceptibility to Scopolamine]

NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:7,111,550...7,127,445

G

interleukin 6

multiple interactions
increases expression

Fatty Acids, Unsaturated deficiency promotes the reaction [Scopolamine results in increased expression of IL6 mRNA]; Scopolamine promotes the reaction [Fatty Acids, Unsaturated deficiency results in increased expression of IL6 mRNA]
acanthoside B inhibits the reaction [Scopolamine results in increased expression of IL6 protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of IL6 protein]
Scopolamine results in increased expression of IL6 mRNA; Scopolamine results in increased expression of IL6 protein

PMID:18357464 PMID:21161262 PMID:31077737

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

inositol 1,4,5-trisphosphate receptor, type 1

increases expression

Scopolamine results in increased expression of ITPR1 mRNA

NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:141,187,418...141,510,491

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
decreases expression

Physostigmine inhibits the reaction [Scopolamine promotes the reaction [SK&F 82958 results in increased expression of JUN mRNA]]; Scopolamine promotes the reaction [SK&F 82958 results in increased expression of JUN mRNA]
Scopolamine results in decreased expression of JUN protein
Donepezil inhibits the reaction [Scopolamine results in decreased expression of JUN protein]; protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of JUN protein]

PMID:11337201 PMID:29133030

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656

G

JunB proto-oncogene, AP-1 transcription factor subunit

decreases expression

Scopolamine results in decreased expression of JUNB mRNA

NCBI chr19:40,081,126...40,082,910
Ensembl chr19:23,176,294...23,178,035

G

potassium voltage-gated channel subfamily A member 4

increases expression

Scopolamine results in increased expression of KCNA4 mRNA

NCBI chr 3:114,211,091...114,218,545
Ensembl chr 3:93,756,446...93,769,162

G

potassium voltage-gated channel subfamily B member 1

increases expression

Scopolamine results in increased expression of KCNB1 mRNA

PMID:12579815 PMID:15567561

NCBI chr 3:176,239,285...176,332,408
Ensembl chr 3:155,822,963...155,916,194

G

potassium voltage-gated channel subfamily D member 2

decreases expression

Scopolamine results in decreased expression of KCND2 mRNA

NCBI chr 4:50,741,595...51,243,540
Ensembl chr 4:49,776,246...50,277,728

G

potassium inwardly-rectifying channel, subfamily J, member 3

multiple interactions

Scopolamine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]

NCBI chr 3:60,353,990...60,518,110
Ensembl chr 3:39,945,351...40,109,124

G

KLF transcription factor 2

decreases expression

Scopolamine results in decreased expression of KLF2 mRNA

NCBI chr16:17,555,136...17,557,768
Ensembl chr16:17,514,552...17,523,944

G

KLF transcription factor 4

decreases expression

Scopolamine results in decreased expression of KLF4 mRNA

NCBI chr 5:75,074,107...75,079,182
Ensembl chr 5:70,278,972...70,283,602

G

leucyl and cystinyl aminopeptidase

multiple interactions

[AGT protein modified form binds to and results in decreased activity of LNPEP protein] which results in decreased susceptibility to Scopolamine

NCBI chr 1:66,931,712...67,027,610
Ensembl chr 1:58,258,642...58,354,544

G

MAP-kinase activating death domain

increases expression

Scopolamine results in increased expression of MADD mRNA

NCBI chr 3:97,570,141...97,613,688
Ensembl chr 3:77,114,314...77,157,701

G

microtubule-associated protein 2

decreases expression
multiple interactions

Scopolamine results in decreased expression of MAP2 protein
Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of MAP2 protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of MAP2 protein]

NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:67,723,371...67,979,809

G

microtubule-associated protein tau

decreases expression

Scopolamine results in decreased expression of MAPT mRNA

NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,138,627...89,236,129

G

myelin basic protein

decreases expression
multiple interactions

Scopolamine results in decreased expression of MBP protein
Melatonin inhibits the reaction [Scopolamine results in decreased expression of MBP protein]

NCBI chr18:78,130,652...78,241,174
Ensembl chr18:75,855,878...75,966,404

G

mucin 5AC, oligomeric mucus/gel-forming

decreases expression

Scopolamine results in decreased expression of MUC5AC protein

PMID:18357464 PMID:21161262

NCBI chr 1:206,293,717...206,326,006
Ensembl chr 1:196,864,336...196,896,475

G

neurofilament heavy chain

multiple interactions
decreases expression

Ashwagandha inhibits the reaction [Scopolamine results in decreased expression of NEFH protein]; withanone inhibits the reaction [Scopolamine results in decreased expression of NEFH protein]

NCBI chr14:84,044,428...84,054,413
Ensembl chr14:79,830,362...79,840,351

G

NFE2 like bZIP transcription factor 2

multiple interactions
decreases expression

7-fluoro-1,3-diphenylisoquinoline-1-amine inhibits the reaction [Scopolamine results in decreased expression of NFE2L2 protein]
Galantamine inhibits the reaction [Scopolamine results in decreased expression of NFE2L2 protein]; intybin inhibits the reaction [Scopolamine results in decreased expression of NFE2L2 protein]

PMID:27346436 PMID:32001261

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737

G

nerve growth factor

decreases response to substance
decreases secretion
multiple interactions
increases response to substance

NGF protein results in decreased susceptibility to Scopolamine
Scopolamine results in decreased secretion of NGF protein
Galantamine promotes the reaction [Scopolamine results in decreased secretion of NGF protein]; intybin inhibits the reaction [Scopolamine results in decreased secretion of NGF protein]; Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NGF mRNA]
NGF protein results in increased susceptibility to Scopolamine

PMID:1661212 PMID:8635431 PMID:16405025 PMID:27346436

NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:189,901,058...189,954,452

G

nitric oxide synthase 2

multiple interactions
increases expression

acanthoside B inhibits the reaction [Scopolamine results in increased expression of NOS2 protein]; Serotonin analog inhibits the reaction [Scopolamine results in increased expression of NOS2 protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of NOS2 protein]

PMID:26408985 PMID:31077737

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210

G

NOVA alternative splicing regulator 1

multiple interactions

Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NOVA1 mRNA]

NCBI chr 6:69,506,983...69,632,437
Ensembl chr 6:63,783,489...63,906,289

G

NOVA alternative splicing regulator 2

multiple interactions

Scopolamine inhibits the reaction [Pilocarpine results in decreased expression of NOVA2 mRNA]

NCBI chr 1:87,700,328...87,741,755
Ensembl chr 1:78,572,279...78,608,021

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
decreases expression

Serotonin analog inhibits the reaction [Scopolamine results in decreased expression of NQO1 protein]

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557

G

N-ribosyldihydronicotinamide:quinone dehydrogenase 2

increases expression

Scopolamine results in increased expression of NQO2 mRNA

NCBI chr17:31,114,825...31,144,062
Ensembl chr17:30,909,187...30,938,320

G

nuclear receptor subfamily 1, group D, member 1

decreases expression

Scopolamine results in decreased expression of NR1D1 mRNA

NCBI chr10:84,224,599...84,231,812
Ensembl chr10:83,728,318...83,735,705

G

nuclear receptor subfamily 4, group A, member 1

decreases expression

Scopolamine results in decreased expression of NR4A1 mRNA

NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:132,374,840...132,389,297

G

neurotrophin 3

multiple interactions

Scopolamine inhibits the reaction [Pilocarpine results in decreased expression of NTF3 mRNA]

NCBI chr 4:160,601,161...160,670,623
Ensembl chr 4:158,914,957...158,984,596

G

neurotrophic receptor tyrosine kinase 2

multiple interactions
decreases expression

Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NTRK2 mRNA]
Scopolamine results in decreased expression of NTRK2 protein
[acanthoside B co-treated with Scopolamine] results in increased phosphorylation of NTRK2 protein; [Tacrine co-treated with Scopolamine] results in increased phosphorylation of NTRK2 protein; Melatonin inhibits the reaction [Scopolamine results in decreased expression of NTRK2 protein]

PMID:8635431 PMID:29476728 PMID:31077737

NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,559,043...5,869,136

G

neurotrophic receptor tyrosine kinase 3

multiple interactions

Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NTRK3 mRNA]

NCBI chr 1:141,526,192...141,913,575
Ensembl chr 1:132,132,849...132,503,286

G

programmed cell death 4

increases expression

Scopolamine results in increased expression of PDCD4 mRNA

NCBI chr 1:262,912,659...262,949,581
Ensembl chr 1:252,921,392...252,944,275

G

prodynorphin

decreases response to substance
multiple interactions
increases expression

PDYN protein modified form results in decreased susceptibility to Scopolamine
MR 2266 inhibits the reaction [PDYN protein modified form results in decreased susceptibility to Scopolamine]
Scopolamine results in increased expression of PDYN mRNA

PMID:7768285 PMID:17540011

NCBI chr 3:137,354,161...137,366,503
Ensembl chr 3:116,900,992...116,913,334

G

proenkephalin

multiple interactions

Scopolamine inhibits the reaction [Haloperidol results in increased expression of PENK mRNA]

NCBI chr 5:21,981,381...21,987,074
Ensembl chr 5:17,183,806...17,189,129

G

phosphoglycerate mutase 1

decreases expression

Scopolamine results in decreased expression of PGAM1 mRNA

NCBI chr 1:250,673,152...250,680,762
Ensembl chr 1:240,723,920...240,738,452

G

prolyl endopeptidase

increases response to substance
increases expression
multiple interactions

PREP protein results in increased susceptibility to Scopolamine
Scopolamine results in increased expression of PREP protein
Piracetam inhibits the reaction [Scopolamine results in increased expression of PREP protein]

PMID:17244263 PMID:18318186

NCBI chr20:50,138,588...50,235,549
Ensembl chr20:48,556,280...48,654,466

G

protein activator of interferon induced protein kinase EIF2AK2

decreases expression

Scopolamine results in decreased expression of PRKRA mRNA

NCBI chr 3:81,982,669...82,002,028
Ensembl chr 3:61,575,447...61,594,347

G

presenilin 2

decreases expression

Scopolamine results in decreased expression of PSEN2 mRNA

NCBI chr13:94,499,451...94,528,419
Ensembl chr13:91,967,983...91,993,174

G

prostaglandin-endoperoxide synthase 2

increases expression
multiple interactions

Scopolamine results in increased expression of PTGS2 protein
acanthoside B inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein]; Serotonin analog inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein]

PMID:26408985 PMID:31077737

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188

G

RAB14, member RAS oncogene family

increases expression

Scopolamine results in increased expression of RAB14 mRNA

NCBI chr 3:38,899,430...38,920,572
Ensembl chr 3:18,501,963...18,523,172

G

Rap guanine nucleotide exchange factor 3

decreases expression

Scopolamine results in decreased expression of RAPGEF3 mRNA

NCBI chr 7:130,754,883...130,777,303
Ensembl chr 7:128,875,773...128,898,521

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

mangiferin inhibits the reaction [Scopolamine results in increased phosphorylation of and results in increased activity of RELA protein]; Scopolamine results in increased phosphorylation of and results in increased activity of RELA protein; timosaponin AIII inhibits the reaction [Scopolamine results in increased phosphorylation of and results in increased activity of RELA protein]

PMID:19182383 PMID:19426756

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484

G

RRAD and GEM like GTPase 2

decreases expression

Scopolamine results in decreased expression of REM2 mRNA

NCBI chr15:31,903,972...31,908,451
Ensembl chr15:27,933,950...27,938,429

G

regulator of G-protein signaling 7 binding protein

decreases expression

Scopolamine results in decreased expression of RGS7BP mRNA

NCBI chr 2:37,867,698...37,965,587
Ensembl chr 2:36,139,201...36,231,505

G

roundabout guidance receptor 3

decreases expression

Scopolamine results in decreased expression of ROBO3 mRNA

NCBI chr 8:45,322,323...45,340,466
Ensembl chr 8:37,133,916...37,151,315

G

Ras-related GTP binding A

increases expression

Scopolamine results in increased expression of RRAGA mRNA

NCBI chr 5:106,159,335...106,160,930
Ensembl chr 5:101,112,859...101,114,510

G

S100 calcium-binding protein A4

decreases expression

Scopolamine results in decreased expression of S100A4 mRNA

NCBI chr 2:178,388,529...178,390,838
Ensembl chr 2:176,091,804...176,093,254

G

sphingosine-1-phosphate receptor 1

increases expression

Scopolamine results in increased expression of S1PR1 mRNA

NCBI chr 2:206,309,715...206,314,070
Ensembl chr 2:203,621,587...203,629,681

G

secretory carrier membrane protein 2

increases expression

Scopolamine results in increased expression of SCAMP2 mRNA

NCBI chr 8:66,861,504...66,888,151
Ensembl chr 8:57,965,631...57,992,646

G

sigma non-opioid intracellular receptor 1

multiple interactions

[2-(4-morpholino)ethyl-1-phenylcyclohexane-1-carboxylate binds to and results in increased activity of SIGMAR1 protein] which results in decreased susceptibility to Scopolamine; [igmesine binds to and results in increased activity of SIGMAR1 protein] which results in decreased susceptibility to Scopolamine

NCBI chr 5:61,700,021...61,702,799
Ensembl chr 5:56,904,159...56,907,017

G

solute carrier family 47 member 1

multiple interactions

Scopolamine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,034,122...46,087,637

G

solute carrier family 47 member 2

multiple interactions

Scopolamine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,490,262...46,532,954
Ensembl chr10:45,991,095...46,033,904

G

sulfotransferase family 1A member 1

increases expression

Scopolamine results in increased expression of SULT1A1 mRNA

NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:181,272,023...181,275,562

G

synaptophysin

multiple interactions
decreases expression
increases expression

cyclo-L-glycyl-L-2-allylproline inhibits the reaction [Scopolamine results in increased expression of SYP protein]
dihydroactinidiolide inhibits the reaction [Scopolamine results in decreased expression of SYP mRNA]; Donepezil inhibits the reaction [Scopolamine results in decreased expression of SYP mRNA]

PMID:20188767 PMID:34371027

NCBI chr X:17,521,348...17,536,449
Ensembl chr X:14,849,444...14,864,745

G

tachykinin, precursor 1

decreases response to substance

TAC1 protein modified form results in decreased susceptibility to Scopolamine

NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:35,679,704...35,687,178

G

tumor necrosis factor

multiple interactions
increases expression

acanthoside B inhibits the reaction [Scopolamine results in increased expression of TNF protein]; mangiferin inhibits the reaction [Scopolamine results in increased expression of TNF protein]; Tacrine inhibits the reaction [Scopolamine results in increased expression of TNF protein]; timosaponin AIII inhibits the reaction [Scopolamine results in increased expression of TNF protein]
Scopolamine results in increased expression of TNF mRNA
Scopolamine results in increased expression of TNF mRNA; Scopolamine results in increased expression of TNF protein

PMID:18357464 PMID:19182383 PMID:19426756 PMID:21161262 PMID:31077737

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

trinucleotide repeat containing adaptor 6A

decreases expression

Scopolamine results in decreased expression of TNRC6A mRNA

NCBI chr 1:186,992,457...187,146,764
Ensembl chr 1:177,646,030...177,715,660

G

TPD52 like 1

increases expression

Scopolamine results in increased expression of TPD52L1 mRNA

NCBI chr 1:27,991,114...28,109,767
Ensembl chr 1:26,172,170...26,291,109

G

VGF nerve growth factor inducible

decreases expression

Scopolamine results in decreased expression of VGF mRNA

NCBI chr12:25,274,004...25,281,803
Ensembl chr12:19,637,320...19,640,341

G

vasoactive intestinal peptide

decreases response to substance

VIP protein results in decreased susceptibility to Scopolamine

NCBI chr 1:44,470,232...44,478,561
Ensembl chr 1:42,065,120...42,073,216

succinylcholine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

butyrylcholinesterase

increases response to substance
increases metabolic processing
increases hydrolysis
affects hydrolysis
multiple interactions
decreases abundance
decreases hydrolysis
affects response to substance

BCHE gene mutant form results in increased susceptibility to Succinylcholine; BCHE gene polymorphism results in increased susceptibility to Succinylcholine; BCHE protein mutant form results in increased susceptibility to Succinylcholine
BCHE protein results in increased metabolism of Succinylcholine
BCHE protein results in increased hydrolysis of Succinylcholine
BCHE protein mutant form affects the hydrolysis of Succinylcholine
[Dichlorvos results in decreased activity of BCHE protein] which results in increased susceptibility to Succinylcholine; Insecticides inhibits the reaction [BCHE protein results in increased metabolism of Succinylcholine]; Organophosphorus Compounds inhibits the reaction [BCHE protein results in increased metabolism of Succinylcholine]; Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine]
BCHE protein results in decreased abundance of Succinylcholine
BCHE protein mutant form results in decreased hydrolysis of Succinylcholine
BCHE affects the susceptibility to Succinylcholine; BCHE gene mutant form affects the susceptibility to Succinylcholine; BCHE gene polymorphism affects the susceptibility to Succinylcholine; BCHE protein affects the susceptibility to Succinylcholine

PMID:726855 PMID:900467 PMID:987736 PMID:1058931 PMID:1147298 More...

NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:158,307,584...158,401,148

G

cholinergic receptor nicotinic alpha 4 subunit

multiple interactions

Succinylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]

NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:168,136,266...168,156,957

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

Succinylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]

NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:175,181,402...175,189,619

G

myoglobin

increases secretion

Succinylcholine results in increased secretion of MB protein

NCBI chr 7:110,640,511...110,647,742
Ensembl chr 7:108,759,904...108,767,383

theophylline

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

abhydrolase domain containing 11

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ABHD11 protein

NCBI chr12:27,318,739...27,322,016
Ensembl chr12:21,682,202...21,685,398

G

ABL proto-oncogene 2, non-receptor tyrosine kinase

decreases expression

Theophylline results in decreased expression of ABL2 mRNA

NCBI chr13:71,223,902...71,319,770
Ensembl chr13:68,673,722...68,839,742

G

acetyl-CoA acyltransferase 1A

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ACAA1 protein

NCBI chr 8:127,956,126...127,966,348
Ensembl chr 8:119,079,775...119,088,624

G

acyl-CoA dehydrogenase medium chain

decreases expression

Theophylline results in decreased expression of ACADM mRNA

NCBI chr 2:245,518,693...245,542,864
Ensembl chr 2:242,858,865...242,883,147

G

angiotensin converting enzyme 2

decreases expression

Theophylline results in decreased expression of ACE2 mRNA

NCBI chr X:33,925,458...33,972,851
Ensembl chr X:30,293,589...30,340,977

G

acyl-CoA thioesterase 7

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ACOT7 protein

NCBI chr 5:167,969,284...168,062,033
Ensembl chr 5:162,684,645...162,779,309

G

acid phosphatase 5, tartrate resistant

increases expression

Theophylline results in increased expression of ACP5 mRNA; Theophylline results in increased expression of ACP5 protein

NCBI chr 8:28,939,984...28,946,639
Ensembl chr 8:20,663,985...20,667,929

G

actin alpha 2, smooth muscle

multiple interactions

Theophylline inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554

G

actin related protein 2

decreases expression

Theophylline results in decreased expression of ACTR2 mRNA

NCBI chr14:98,500,119...98,535,092
Ensembl chr14:94,296,443...94,340,524

G

actin related protein 3

decreases expression

Theophylline results in decreased expression of ACTR3 mRNA

NCBI chr13:39,353,413...39,396,509
Ensembl chr13:36,800,093...36,844,124

G

adenosine deaminase domain containing 1

decreases expression

Theophylline results in decreased expression of ADAD1 mRNA

NCBI chr 2:119,948,809...120,005,920
Ensembl chr 2:119,948,926...120,005,913

G

ADAMTS-like 3

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ADAMTSL3 protein

NCBI chr 1:145,698,004...146,006,195
Ensembl chr 1:136,288,793...136,596,986

G

adenosine A1 receptor

decreases activity
decreases expression
multiple interactions

Theophylline results in decreased activity of ADORA1 protein
Theophylline results in decreased expression of ADORA1 mRNA
Theophylline binds to and results in decreased activity of ADORA1 protein

PMID:9535120 PMID:12153486 PMID:14992338 PMID:15708489

NCBI chr13:48,210,922...48,247,826
Ensembl chr13:45,658,872...45,695,801

G

ALF transcription elongation factor 4

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of AFF4 protein

NCBI chr10:37,998,319...38,080,580
Ensembl chr10:37,498,825...37,579,751

G

ArfGAP with FG repeats 1

increases expression

Theophylline results in increased expression of AGFG1 mRNA

NCBI chr 9:91,572,962...91,630,688
Ensembl chr 9:84,125,120...84,178,128

G

AT hook containing transcription factor 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of AHCTF1 protein

NCBI chr13:94,013,894...94,068,348
Ensembl chr13:91,481,936...91,536,391

G

AKT1 substrate 1

increases expression

Theophylline results in increased expression of AKT1S1 mRNA

NCBI chr 1:104,469,823...104,476,168
Ensembl chr 1:95,332,898...95,339,677

G

aldolase, fructose-bisphosphate C

decreases expression

Theophylline results in decreased expression of ALDOC mRNA

NCBI chr10:63,715,544...63,719,133
Ensembl chr10:63,217,451...63,221,066

G

ALG9, alpha-1,2-mannosyltransferase

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ALG9 protein

NCBI chr 8:60,013,429...60,085,159
Ensembl chr 8:51,119,365...51,182,261

G

androgen regulated protein

increases expression

Theophylline results in increased expression of CST4 mRNA

NCBI chr 3:157,171,739...157,178,262
Ensembl chr 3:136,718,602...136,724,966

G

ankyrin repeat and death domain containing 1A

increases expression

Theophylline results in increased expression of ANKDD1A mRNA

NCBI chr 8:74,912,707...74,938,870
Ensembl chr 8:66,017,773...66,042,651

G

ankyrin repeat domain 13C

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ANKRD13C protein

NCBI chr 2:249,679,752...249,729,272
Ensembl chr 2:247,022,286...247,070,433
Ensembl chr 4:247,022,286...247,070,433

G

ankyrin repeat domain 44

increases expression

Theophylline results in increased expression of ANKRD44 mRNA

NCBI chr 9:63,621,193...63,921,999
Ensembl chr 9:56,126,747...56,427,508

G

amine oxidase, copper containing 1

increases activity
decreases expression

Theophylline results in increased activity of AOC1 protein
Theophylline results in decreased expression of AOC1 mRNA

PMID:2860926 PMID:18951874

NCBI chr 4:79,143,126...79,162,705
Ensembl chr 4:77,812,260...77,831,840

G

apurinic/apyrimidinic endodeoxyribonuclease 1

decreases expression

Theophylline results in decreased expression of APEX1 mRNA

NCBI chr15:26,618,146...26,620,330
Ensembl chr15:24,144,362...24,146,785

G

ARF GTPase 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ARF1 protein

NCBI chr10:44,497,543...44,513,994
Ensembl chr10:43,997,986...44,014,434

G

Rho GTPase activating protein 15

increases expression

Theophylline results in increased expression of ARHGAP15 mRNA

NCBI chr 3:48,382,945...49,002,213
Ensembl chr 3:27,989,633...28,600,265

G

AT-rich interaction domain 2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ARID2 protein

NCBI chr 7:129,326,371...129,443,813
Ensembl chr 7:127,447,278...127,563,512

G

armadillo repeat containing 8

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ARMC8 protein

NCBI chr 8:108,916,274...109,010,877
Ensembl chr 8:100,036,946...100,131,520

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ARNT protein

NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:182,997,736...183,056,580

G

arylsulfatase B

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ARSB protein

NCBI chr 2:26,736,395...26,895,682
Ensembl chr 2:25,002,346...25,162,671

G

ArfGAP with SH3 domain, ankyrin repeat and PH domain 1

increases expression

Theophylline results in increased expression of ASAP1 mRNA

NCBI chr 7:97,675,354...97,982,523
Ensembl chr 7:95,787,818...96,092,754

G

argininosuccinate lyase

decreases expression

Theophylline results in decreased expression of ASL mRNA

NCBI chr12:32,295,779...32,313,257
Ensembl chr12:26,659,565...26,679,662

G

autophagy related 3

increases expression

Theophylline results in increased expression of ATG3 mRNA

NCBI chr11:69,130,948...69,159,280
Ensembl chr11:55,624,917...55,653,224

G

ATP synthase mitochondrial F1 complex assembly factor 2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ATPAF2 protein

NCBI chr10:45,705,157...45,721,282
Ensembl chr10:45,197,441...45,221,026

G

ATRX, chromatin remodeler

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ATRX protein

NCBI chr X:74,916,548...75,062,880
Ensembl chr X:70,850,981...70,997,330

G

aurora kinase B

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of AURKB protein

NCBI chr10:54,243,116...54,249,675
Ensembl chr10:53,745,142...53,750,837

G

5-azacytidine induced 2

multiple interactions
decreases expression

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of AZI2 protein
Theophylline results in decreased expression of AZI2 mRNA

NCBI chr 8:126,651,268...126,674,795
Ensembl chr 8:117,773,279...117,797,847

G

beta-1,3-N-acetylgalactosaminyltransferase 2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of B3GALNT2 protein

NCBI chr17:56,030,409...56,072,952
Ensembl chr17:51,334,921...51,377,469

G

beta-1,4-galactosyltransferase 7

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of B4GALT7 protein

NCBI chr17:9,023,667...9,032,742
Ensembl chr17:9,018,935...9,027,573

G

BRISC and BRCA1 A complex member 2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of BABAM2 protein

NCBI chr 6:30,089,065...30,467,508
Ensembl chr 6:24,369,022...24,833,951

G

BAG cochaperone 5

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of BAG5 protein

NCBI chr 6:136,589,623...136,593,278
Ensembl chr 6:130,768,141...130,772,970

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

[Theophylline co-treated with Cisplatin] results in decreased expression of BCL2 protein; [Theophylline co-treated with Gemcitabine] results in decreased expression of BCL2 protein; IL4 protein inhibits the reaction [Theophylline results in decreased expression of BCL2 protein]
Theophylline results in decreased expression of BCL2 mRNA; Theophylline results in decreased expression of BCL2 protein

PMID:8822937 PMID:9312165 PMID:10877050 PMID:10891529 PMID:15313391 More...

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BAF chromatin remodeling complex subunit BCL7C

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of BCL7C protein

NCBI chr 1:191,703,432...191,754,751
Ensembl chr 1:182,260,164...182,324,163

G

BCR activator of RhoGEF and GTPase

increases expression

Theophylline results in increased expression of BCR mRNA

NCBI chr20:13,468,732...13,596,333
Ensembl chr20:13,471,668...13,597,016

G

B-cell linker

increases expression

Theophylline results in increased expression of BLNK mRNA

NCBI chr 1:249,703,064...249,770,533
Ensembl chr 1:239,753,648...239,821,113

G

bromodomain PHD finger transcription factor

decreases expression

Theophylline results in decreased expression of BPTF mRNA

NCBI chr10:92,480,007...92,582,485
Ensembl chr10:91,982,758...92,082,769

G

B-Raf proto-oncogene, serine/threonine kinase

multiple interactions

[Theophylline results in increased abundance of Cyclic AMP] which results in increased activity of BRAF protein

NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:68,384,649...68,510,463

G

BTB domain containing 10

increases expression

Theophylline results in increased expression of BTBD10 mRNA

NCBI chr 1:176,865,817...176,923,663
Ensembl chr 1:167,431,329...167,489,916

G

BTG anti-proliferation factor 3

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of BTG3 protein

NCBI chr11:30,517,068...30,532,981
Ensembl chr11:17,030,160...17,046,170

G

C2 calcium-dependent domain containing 5

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of C2CD5 protein

NCBI chr 4:177,700,515...177,790,576
Ensembl chr 4:175,969,545...176,055,558

G

similar to human chromosome 3 open reading frame 20

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of C3ORF20 protein

NCBI chr 4:124,422,033...124,470,657
Ensembl chr 4:124,432,193...124,469,254

G

complement C5

multiple interactions

Theophylline inhibits the reaction [C5 protein modified form results in increased abundance of Superoxides]; Theophylline promotes the reaction [C5 protein modified form results in increased abundance of Superoxides]

NCBI chr 3:38,668,174...38,759,468
Ensembl chr 3:18,270,696...18,361,994

G

calumenin

increases expression

Theophylline results in increased expression of CALU mRNA

NCBI chr 4:58,914,456...58,941,957
Ensembl chr 4:57,948,997...57,976,593

G

calcium/calmodulin-dependent protein kinase II delta

decreases expression

Theophylline results in decreased expression of CAMK2D mRNA

NCBI chr 2:217,698,324...217,961,898
Ensembl chr 2:215,024,004...215,286,178

G

cullin-associated and neddylation-dissociated 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of CAND1 protein

NCBI chr 7:56,566,765...56,604,653
Ensembl chr 7:54,680,900...54,718,993

G

cell cycle associated protein 1

increases expression

Theophylline results in increased expression of CAPRIN1 mRNA

NCBI chr 3:110,606,489...110,685,408
Ensembl chr 3:90,153,620...90,230,502

G

capping actin protein of muscle Z-line subunit alpha 1

decreases expression

Theophylline results in decreased expression of CAPZA1 mRNA

NCBI chr 2:195,008,035...195,053,100
Ensembl chr 2:192,319,702...192,364,480

G

caspase 2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of CASP2 protein

NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:71,149,669...71,167,379

G

caspase 3

increases activity

Theophylline results in increased activity of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions

Theophylline inhibits the reaction [Phenylisopropyladenosine results in increased expression of CAT protein]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478

G

caveolin 1

increases expression

Theophylline results in increased expression of CAV1 mRNA

NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:45,634,918...45,673,705

G

coiled-coil domain containing 181

decreases expression

Theophylline results in decreased expression of CCDC181 mRNA

NCBI chr13:79,157,708...79,171,365
Ensembl chr13:76,624,567...76,638,224

G

coiled-coil domain containing 30

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CCDC30 protein

NCBI chr 5:138,212,067...138,305,465
Ensembl chr 5:132,926,615...133,019,659

G

coiled-coil domain containing 82

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CCDC82 protein

NCBI chr 8:18,509,293...18,665,008
Ensembl chr 8:10,228,430...10,265,963

G

coiled-coil domain containing 93

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CCDC93 protein

NCBI chr13:35,160,354...35,233,877
Ensembl chr13:32,607,587...32,676,023

G

C-C motif chemokine ligand 2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CCL2 protein

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226

G

cyclin D1

multiple interactions

[Theophylline results in increased abundance of Cyclic AMP] which results in increased expression of CCND1 protein
[Theophylline results in increased abundance of Cyclic AMP] which results in increased expression of CCND1 protein; sorafenib inhibits the reaction [[Theophylline results in increased abundance of Cyclic AMP] which results in increased expression of CCND1 protein]

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602

G

coiled-coil serine-rich protein 2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of CCSER2 protein

NCBI chr16:12,633,374...12,746,045
Ensembl chr16:12,613,103...12,725,738

G

CD33 molecule

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CD33 protein

NCBI chr 1:103,071,985...103,086,687
Ensembl chr 1:93,930,971...93,950,149

G

CD36 molecule

decreases expression

Theophylline results in decreased expression of CD36 mRNA

NCBI chr 4:18,209,088...18,302,142
Ensembl chr 4:17,354,466...17,513,903

G

Cd4 molecule

decreases expression

Theophylline results in decreased expression of CD4 protein

NCBI chr 4:159,355,147...159,381,636
Ensembl chr 4:157,668,878...157,695,191

G

cyclin-dependent kinase 13

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of CDK13 protein

NCBI chr17:51,945,975...52,040,218
Ensembl chr17:47,251,163...47,341,721

G

cyclin-dependent kinase inhibitor 1B

multiple interactions

[Theophylline results in increased abundance of Cyclic AMP] which results in increased expression of CDKN1B protein
[Theophylline results in increased abundance of Cyclic AMP] which results in increased expression of CDKN1B protein; sorafenib inhibits the reaction [[Theophylline results in increased abundance of Cyclic AMP] which results in increased expression of CDKN1B protein]

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982

G

cyclin-dependent kinase inhibitor 1C

increases expression

Theophylline results in increased expression of CDKN1C mRNA

NCBI chr 1:208,084,801...208,087,680
Ensembl chr 1:198,655,407...198,658,048

G

CEA cell adhesion molecule 1

decreases expression

Theophylline results in decreased expression of CEACAM1 mRNA

NCBI chr 1:90,171,401...90,187,810
Ensembl chr 1:81,043,595...81,059,992

G

centromere protein U

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CENPU protein

NCBI chr16:52,448,446...52,471,662
Ensembl chr16:45,714,294...45,738,823

G

centrosomal protein 290

decreases expression

Theophylline results in decreased expression of CEP290 mRNA

NCBI chr 7:37,196,765...37,285,955
Ensembl chr 7:35,310,199...35,399,392

G

centrosomal protein 63

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CEP63 protein

NCBI chr 8:112,041,586...112,093,061
Ensembl chr 8:103,162,700...103,214,177

G

choline/ethanolamine phosphotransferase 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of CEPT1 protein

NCBI chr 2:196,682,455...196,724,430
Ensembl chr 2:193,993,447...194,035,578

G

cilia and flagella associated protein 97

increases expression

Theophylline results in increased expression of CFAP97 mRNA

NCBI chr16:52,818,693...52,867,775
Ensembl chr16:46,086,111...46,125,933

G

glycoprotein hormones, alpha polypeptide

multiple interactions
increases stability
increases expression

[Theophylline co-treated with Butyric Acid] results in increased expression of CGA mRNA; Theophylline inhibits the reaction [Butyric Acid results in decreased stability of CGA mRNA]; Theophylline promotes the reaction [Butyric Acid results in increased expression of CGA protein]
Theophylline results in increased stability of CGA mRNA
Theophylline results in increased expression of CGA protein

PMID:1693836 PMID:1693837

NCBI chr 5:54,283,109...54,295,464
Ensembl chr 5:49,487,068...49,499,191

G

C-type lectin domain containing 16A

decreases expression

Theophylline results in decreased expression of CLEC16A mRNA

NCBI chr10:5,434,725...5,631,246
Ensembl chr10:4,928,030...5,123,578

G

C-type lectin domain family 4, member F

decreases expression

Theophylline results in decreased expression of CLEC4F mRNA

NCBI chr 4:117,686,686...117,696,407
Ensembl chr 4:116,129,023...116,138,775

G

ClpB family mitochondrial disaggregase

multiple interactions
increases expression

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CLPB protein
Theophylline results in increased expression of CLPB mRNA

NCBI chr 1:165,440,705...165,563,514
Ensembl chr 1:156,028,930...156,168,788

G

clusterin

increases expression

Theophylline results in increased expression of CLU mRNA

NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315

G

collagen type I alpha 1 chain

multiple interactions

Theophylline inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Theophylline promotes the reaction [Dexamethasone inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624

G

coenzyme Q4

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of COQ4 protein

NCBI chr 3:33,457,834...33,468,387
Ensembl chr 3:13,060,455...13,068,799

G

cytochrome c oxidase subunit 5B

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of COX5B protein

NCBI chr 9:46,417,735...46,419,664
Ensembl chr 9:38,921,967...38,925,052

G

carboxypeptidase M

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CPM protein

NCBI chr 7:55,111,599...55,172,114
Ensembl chr 7:53,225,696...53,286,220

G

copine 1

affects binding

Theophylline binds to CPNE1 protein

NCBI chr 3:165,047,615...165,089,994
Ensembl chr 3:144,588,995...144,598,636

G

cysteine-rich with EGF-like domains 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CRELD1 protein

NCBI chr 4:148,187,510...148,197,120
Ensembl chr 4:146,631,883...146,641,499

G

CREB regulated transcription coactivator 3

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of CRTC3 protein

NCBI chr 1:143,962,038...144,064,324
Ensembl chr 1:134,554,696...134,655,500

G

colony stimulating factor 2

multiple interactions
decreases expression

[Theophylline co-treated with Dexamethasone] inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]; Theophylline inhibits the reaction [CSF2 protein results in increased expression of EDN1 mRNA]; Theophylline promotes the reaction [IL1B protein results in increased secretion of CSF2 protein]; trichostatin A inhibits the reaction [[Theophylline co-treated with Dexamethasone] inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]]
Theophylline results in decreased expression of CSF2 mRNA

PMID:10374451 PMID:10596698 PMID:12070353

NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,386,945...38,389,199

G

colony stimulating factor 3

increases expression

Theophylline results in increased expression of CSF3 protein

NCBI chr10:84,157,485...84,159,860
Ensembl chr10:83,661,207...83,663,603

G

casein kinase 1, epsilon

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CSNK1E protein

NCBI chr 7:112,863,726...112,887,338
Ensembl chr 7:110,983,318...111,006,794

G

CTP synthase 1

decreases expression

Theophylline results in decreased expression of CTPS1 mRNA

NCBI chr 5:139,372,349...139,440,441
Ensembl chr 5:134,125,025...134,154,180

G

chymotrypsin-like

increases expression

Theophylline results in increased expression of CTRL mRNA

NCBI chr19:50,737,078...50,740,659
Ensembl chr19:33,827,229...33,833,626

G

cathepsin B

increases expression

Theophylline results in increased expression of CTSB mRNA

NCBI chr15:41,565,607...41,586,479
Ensembl chr15:37,389,629...37,410,500

G

cathepsin L

decreases expression

Theophylline results in decreased expression of CTSL mRNA

NCBI chr17:770,104...776,266
Ensembl chr17:764,309...770,548

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
increases chemical synthesis
affects response to substance
affects hydroxylation
affects metabolic processing
increases metabolic processing
decreases activity

[CYP1A2 protein binds to and results in increased metabolism of Caffeine] which results in increased chemical synthesis of Theophylline; [Ofloxacin co-treated with Clarithromycin] inhibits the reaction [CYP1A2 protein results in increased metabolism of Theophylline]; Fluvoxamine inhibits the reaction [CYP1A2 protein affects the metabolism of Theophylline]; Griseofulvin promotes the reaction [CYP1A2 protein affects the metabolism of Theophylline]; zafirlukast inhibits the reaction [CYP1A2 protein results in increased metabolism of Theophylline]
CYP1A2 protein results in increased chemical synthesis of Theophylline
CYP1A2 gene SNP affects the susceptibility to Theophylline
CYP1A2 promoter SNP affects the hydroxylation of Theophylline
CYP1A2 gene SNP affects the metabolism of Theophylline; CYP1A2 protein affects the metabolism of Theophylline
andrographolide affects the reaction [CYP1A2 protein results in increased metabolism of Theophylline]; Plant Extracts affects the reaction [CYP1A2 protein results in increased metabolism of Theophylline]; rutecarpine promotes the reaction [CYP1A2 protein affects the metabolism of Theophylline]
Theophylline results in decreased activity of CYP1A2 protein

PMID:1302044 PMID:9029748 PMID:9701106 PMID:11408986 PMID:11465391 More...

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 27, subfamily a, polypeptide 1

decreases expression

Theophylline results in decreased expression of CYP27A1 protein

NCBI chr 9:83,712,402...83,743,222
Ensembl chr 9:76,264,860...76,294,551

G

cytochrome P450, family 2, subfamily d, polypeptide 3

decreases expression

Theophylline results in decreased expression of CYP2D3 mRNA

NCBI chr 7:115,797,785...115,802,142
Ensembl chr 7:113,908,947...113,922,084

G

cytochrome P450, family 2, subfamily e, polypeptide 1

affects metabolic processing
increases chemical synthesis
affects hydroxylation

CYP2E1 protein affects the metabolism of Theophylline
CYP2E1 protein results in increased chemical synthesis of Theophylline
CYP2E1 promoter SNP affects the hydroxylation of Theophylline

PMID:1302044 PMID:15948934 PMID:15985363 PMID:16841220

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 2, subfamily r, polypeptide 1

decreases expression

Theophylline results in decreased expression of CYP2R1 protein

NCBI chr 1:178,166,984...178,232,191
Ensembl chr 1:168,751,038...168,797,759

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

[Ofloxacin co-treated with Clarithromycin] inhibits the reaction [CYP3A4 protein results in increased metabolism of Theophylline]

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008

G

cysteinyl leukotriene receptor 1

decreases expression

Theophylline results in decreased expression of CYSLTR1 mRNA

NCBI chr X:75,734,281...75,762,873
Ensembl chr X:71,663,821...71,690,121

G

DAB adaptor protein 2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of DAB2 protein

NCBI chr 2:57,241,947...57,294,893
Ensembl chr 2:55,514,700...55,567,476

G

dishevelled-binding antagonist of beta-catenin 3

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of DACT3 protein

NCBI chr 1:86,674,989...86,686,722
Ensembl chr 1:77,546,900...77,558,630

G

discoidin, CUB and LCCL domain containing 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of DCBLD1 protein

NCBI chr20:31,618,556...31,711,697
Ensembl chr20:31,618,542...31,711,692

G

DNA damage inducible 1 homolog 2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of DDI2 protein

NCBI chr 5:159,272,625...159,318,365
Ensembl chr 5:153,995,589...154,035,283

G

DEAH-box helicase 8

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of DHX8 protein

NCBI chr10:87,167,861...87,204,426
Ensembl chr10:86,667,834...86,705,137

G

discs large MAGUK scaffold protein 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of DLG1 protein

NCBI chr11:82,416,853...82,607,797
Ensembl chr11:68,911,883...69,102,689

G

distal membrane arm assembly component 2 like

decreases expression

Theophylline results in decreased expression of DMAC2L mRNA

NCBI chr 6:93,941,605...93,959,932
Ensembl chr 6:88,205,700...88,223,933

G

DnaJ heat shock protein family (Hsp40) member C15

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of DNAJC15 protein

NCBI chr15:59,594,314...59,658,862
Ensembl chr15:53,184,855...53,249,675

G

DnaJ heat shock protein family (Hsp40) member C4

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of DNAJC4 protein

NCBI chr 1:213,607,397...213,611,614
Ensembl chr 1:204,178,191...204,182,387

G

dedicator of cytokinesis 4

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of DOCK4 protein

NCBI chr 6:63,240,050...63,629,772
Ensembl chr 6:57,512,908...57,901,855

G

dolichol kinase

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of DOLK protein

NCBI chr 3:33,955,642...33,957,680
Ensembl chr 3:13,557,817...13,559,917

G

dopamine receptor D5

increases expression

Theophylline results in increased expression of DRD5 mRNA

NCBI chr14:76,700,244...76,703,344
Ensembl chr14:72,489,347...72,490,774

G

dual specificity phosphatase 19

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of DUSP19 protein

NCBI chr 3:85,945,289...86,081,289
Ensembl chr 3:65,538,420...65,553,534

G

glutamyl-tRNA synthetase 2, mitochondrial

increases expression

Theophylline results in increased expression of EARS2 mRNA

NCBI chr 1:186,025,740...186,057,165
Ensembl chr 1:176,597,986...176,625,836

G

endothelin 1

multiple interactions

Theophylline inhibits the reaction [CSF2 protein results in increased expression of EDN1 mRNA]

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885

G

egl-9 family hypoxia-inducible factor 3

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of EGLN3 protein

NCBI chr 6:77,385,549...77,411,015
Ensembl chr 6:71,650,297...71,675,766

G

eukaryotic translation initiation factor 1B

decreases expression

Theophylline results in decreased expression of EIF1B mRNA

NCBI chr 8:129,080,497...129,083,772
Ensembl chr 8:120,203,451...120,206,176
Ensembl chr 5:120,203,451...120,206,176

G

eukaryotic translation initiation factor 2 subunit gamma

increases expression

Theophylline results in increased expression of EIF2S3 mRNA

NCBI chr X:62,910,292...62,933,936
Ensembl chr X:58,917,490...58,940,686

G

eukaryotic translation initiation factor 3, subunit A

increases expression

Theophylline results in increased expression of EIF3A mRNA

NCBI chr 1:269,888,730...269,925,785
Ensembl chr 1:259,902,680...259,932,976

G

eukaryotic translation initiation factor 3, subunit B

increases expression

Theophylline results in increased expression of EIF3B mRNA

NCBI chr12:19,310,308...19,334,768
Ensembl chr12:14,196,403...14,220,886

G

eukaryotic translation initiation factor 3 subunit E

decreases expression

Theophylline results in decreased expression of EIF3E mRNA

NCBI chr 7:76,224,567...76,257,346
Ensembl chr 7:74,339,828...74,373,096

G

eukaryotic translation initiation factor 4B

increases expression

Theophylline results in increased expression of EIF4B mRNA

NCBI chr 7:135,085,259...135,107,054

G

eukaryotic translation initiation factor 5

decreases expression

Theophylline results in decreased expression of EIF5 mRNA

NCBI chr 6:136,410,333...136,418,827
Ensembl chr 6:130,589,143...130,597,656

G

elongator acetyltransferase complex subunit 6

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ELP6 protein

NCBI chr 8:119,158,380...119,173,483
Ensembl chr 8:110,279,979...110,295,067

G

ER membrane protein complex subunit 3

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of EMC3 protein

NCBI chr 4:148,218,686...148,234,595
Ensembl chr 4:146,663,067...146,679,029

G

ectonucleoside triphosphate diphosphohydrolase 5

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ENTPD5 protein

NCBI chr 6:109,750,210...109,786,376
Ensembl chr 6:104,019,185...104,055,530

G

ectopic P-granules 5 autophagy tethering factor

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of EPG5 protein

NCBI chr18:73,679,106...73,776,694
Ensembl chr18:71,404,010...71,501,502

G

epidermal growth factor receptor pathway substrate 15

decreases expression

Theophylline results in decreased expression of EPS15 mRNA

NCBI chr 5:129,274,487...129,374,856
Ensembl chr 5:124,045,926...124,146,221

G

EPS8 signaling adaptor L1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of EPS8L1 protein

NCBI chr 1:78,386,916...78,409,972
Ensembl chr 1:69,344,243...69,363,524

G

ERCC excision repair 5, endonuclease

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ERCC5 protein

NCBI chr 9:53,801,471...53,846,611
Ensembl chr 9:46,309,389...46,354,472

G

Ets2 repressor factor

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ERF protein

NCBI chr 1:89,957,760...89,966,213
Ensembl chr 1:80,829,935...80,838,388

G

endoplasmic reticulum-golgi intermediate compartment 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ERGIC1 protein

NCBI chr10:17,035,615...17,131,411
Ensembl chr10:16,531,194...16,626,957

G

ER lipid raft associated 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ERLIN1 protein

NCBI chr 1:252,870,356...252,905,681
Ensembl chr 1:242,921,152...242,956,394

G

ER lipid raft associated 2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ERLIN2 protein

NCBI chr16:71,720,486...71,736,999
Ensembl chr16:65,018,532...65,033,671

G

ecotropic viral integration site 2B

decreases expression

Theophylline results in decreased expression of EVI2B mRNA

NCBI chr10:64,970,659...64,972,277
Ensembl chr10:64,471,505...64,481,560

G

exosome component 3

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of EXOSC3 protein

NCBI chr 5:64,369,495...64,374,711
Ensembl chr 5:59,573,886...59,579,060

G

exosome component 4

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of EXOSC4 protein

NCBI chr 7:109,928,491...109,931,233
Ensembl chr 7:108,047,831...108,050,573

G

EYA transcriptional coactivator and phosphatase 3

increases expression

Theophylline results in increased expression of EYA3 mRNA

NCBI chr 5:150,090,535...150,218,855
Ensembl chr 5:144,806,577...144,934,518

G

fatty acid binding protein 1

increases expression

Theophylline results in increased expression of FABP1 mRNA

NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:103,191,006...103,194,788

G

fatty acid desaturase 3

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of FADS3 protein

NCBI chr 1:216,110,547...216,127,431
Ensembl chr 1:206,685,894...206,704,769

G

family with sequence similarity 171, member B

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of FAM171B protein

NCBI chr 3:89,337,566...89,392,973
Ensembl chr 3:68,930,822...68,986,127

G

family with sequence similarity 222, member B

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of FAM222B protein

NCBI chr10:63,484,651...63,550,422
Ensembl chr10:62,986,571...63,052,350

G

F-box protein 8

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of FBXO8 protein

NCBI chr16:38,676,011...38,721,849
Ensembl chr16:33,665,306...33,711,272

G

FCH and double SH3 domains 2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of FCHSD2 protein

NCBI chr 1:164,775,916...165,097,391
Ensembl chr 1:155,444,460...155,685,539

G

ferredoxin reductase

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of FDXR protein

NCBI chr10:101,006,845...101,015,582
Ensembl chr10:100,507,865...100,516,658

G

fibrinogen alpha chain

increases expression

Theophylline results in increased expression of FGA mRNA

NCBI chr 2:170,672,169...170,679,572
Ensembl chr 2:168,374,120...168,381,528

G

fibrinogen beta chain

increases expression

Theophylline results in increased expression of FGB mRNA

NCBI chr 2:170,693,966...170,700,875
Ensembl chr 2:168,394,916...168,405,979

G

fibroblast growth factor 23

increases expression
multiple interactions

Theophylline results in increased expression of FGF23 protein
Calcifediol inhibits the reaction [Theophylline results in increased expression of FGF23 protein]

NCBI chr 4:161,600,439...161,609,991
Ensembl chr 4:159,914,272...159,923,821

G

four and a half LIM domains 3

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of FHL3 protein

NCBI chr 5:142,238,634...142,246,011
Ensembl chr 5:136,950,411...136,961,317

G

FGF1 intracellular binding protein

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of FIBP protein

NCBI chr 1:212,197,216...212,201,732
Ensembl chr 1:202,768,078...202,772,399

G

factor interacting with PAPOLA and CPSF1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of FIP1L1 protein

NCBI chr14:33,969,341...34,030,871
Ensembl chr14:33,617,720...33,675,708

G

fat storage-inducing transmembrane protein 2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of FITM2 protein

NCBI chr 3:172,560,781...172,567,291
Ensembl chr 3:152,141,346...152,147,858

G

flotillin 2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of FLOT2 protein

NCBI chr10:63,424,084...63,445,811
Ensembl chr10:62,920,665...62,947,756

G

formin binding protein 4

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of FNBP4 protein

NCBI chr 3:97,188,852...97,218,916
Ensembl chr 3:76,733,027...76,763,079

G

farnesyltransferase, CAAX box, subunit beta

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of FNTB protein

NCBI chr 6:101,269,657...101,352,716
Ensembl chr 6:95,470,683...95,619,586

G

folate receptor alpha

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of FOLR1 protein

NCBI chr 1:165,631,462...165,650,430
Ensembl chr 1:156,219,460...156,230,667

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Theophylline inhibits the reaction [Haloperidol results in increased expression of FOS mRNA]; Theophylline inhibits the reaction [Reserpine results in increased expression of FOS protein]

PMID:8577368 PMID:10199625

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box F2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of FOXF2 protein

NCBI chr17:33,044,446...33,051,259
Ensembl chr17:32,836,777...32,842,176

G

forkhead box K2

increases expression

Theophylline results in increased expression of FOXK2 mRNA

NCBI chr10:107,040,933...107,090,860
Ensembl chr10:106,542,566...106,592,563

G

fibronectin type III and SPRY domain containing 1-like

increases expression

Theophylline results in increased expression of FSD1L mRNA

NCBI chr 5:73,052,565...73,130,292
Ensembl chr 5:68,258,932...68,334,928

G

GABA type A receptor associated protein like 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of GABARAPL1 protein

NCBI chr 4:164,666,332...164,675,474
Ensembl chr 4:162,980,249...162,989,450

G

gamma-aminobutyric acid type A receptor subunit alpha 1

multiple interactions

Theophylline results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]

NCBI chr10:27,096,731...27,152,563
Ensembl chr10:26,595,160...26,650,864

G

gamma-aminobutyric acid type A receptor subunit beta 2

multiple interactions

Theophylline results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]

NCBI chr10:27,438,127...27,657,680
Ensembl chr10:26,936,551...27,151,251

G

gamma-aminobutyric acid type A receptor subunit gamma 2

multiple interactions

Theophylline results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]

NCBI chr10:26,876,926...26,965,523
Ensembl chr10:26,374,694...26,464,346

G

gamma-aminobutyric acid type A receptor subunit rho 2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of GABRR2 protein

NCBI chr 5:52,242,564...52,286,255
Ensembl chr 5:47,452,150...47,489,809

G

glucokinase

increases expression

Theophylline results in increased expression of GCK mRNA

NCBI chr14:84,999,019...85,041,098
Ensembl chr14:80,785,060...80,826,995

G

growth differentiation factor 15

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of GDF15 protein

NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,805,239...18,808,055

G

glutamine fructose-6-phosphate transaminase 1

increases expression

Theophylline results in increased expression of GFPT1 mRNA

NCBI chr 4:121,054,023...121,103,799
Ensembl chr 4:119,496,714...119,546,471

G

geranylgeranyl diphosphate synthase 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of GGPS1 protein

NCBI chr17:55,958,750...55,982,762
Ensembl chr17:51,263,263...51,276,220

G

G kinase anchoring protein 1

increases expression

Theophylline results in increased expression of GKAP1 mRNA

NCBI chr17:6,389,377...6,429,091
Ensembl chr17:6,383,963...6,423,679

G

glutaredoxin 3

increases expression

Theophylline results in increased expression of GLRX3 mRNA

NCBI chr 1:201,671,410...201,701,722
Ensembl chr 1:192,241,701...192,272,010

G

glutaminase

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of GLS protein

NCBI chr 9:56,836,584...56,908,861
Ensembl chr 9:49,344,781...49,416,900

G

G protein subunit alpha i1

decreases expression
increases expression

Theophylline results in decreased expression of GNAI1 protein
Theophylline results in increased expression of GNAI1 mRNA

NCBI chr 4:17,706,061...17,790,176
Ensembl chr 4:16,814,001...16,896,417

G

G protein subunit alpha i2

decreases expression

Theophylline results in decreased expression of GNAI2 protein

NCBI chr 8:117,167,045...117,187,652
Ensembl chr 8:108,288,401...108,308,979

G

G protein subunit alpha q

decreases expression

Theophylline results in decreased expression of GNAQ protein

NCBI chr 1:222,852,453...223,098,754
Ensembl chr 1:213,424,465...213,667,672

G

GNAS complex locus

decreases expression

Theophylline results in decreased expression of GNAS protein

NCBI chr 3:183,489,648...183,554,570
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262

G

G protein subunit beta 1

multiple interactions
decreases expression

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of GNB1 protein
Theophylline results in decreased expression of GNB1 mRNA

PMID:16083514 PMID:18951874

NCBI chr 5:171,357,778...171,424,489
Ensembl chr 5:166,075,629...166,142,124

G

G patch domain containing 8

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of GPATCH8 protein

NCBI chr10:87,432,020...87,512,594
Ensembl chr10:87,433,266...87,512,419

G

glycoprotein m6a

increases expression

Theophylline results in increased expression of GPM6A mRNA

NCBI chr16:43,374,385...43,706,461
Ensembl chr16:36,641,284...36,973,475

G

G protein-coupled receptor 137C

increases expression

Theophylline results in increased expression of GPR137C mRNA

NCBI chr15:20,905,923...20,972,318
Ensembl chr15:18,426,223...18,490,807

G

glutathione peroxidase 1

decreases expression

Theophylline results in decreased expression of GPX1 mRNA

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024

G

G protein-coupled receptor kinase 3

multiple interactions
decreases expression

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of GRK3 protein
Theophylline results in decreased expression of GRK3 mRNA

NCBI chr12:49,285,228...49,395,803
Ensembl chr12:43,624,897...43,731,262

G

glutamate metabotropic receptor 1

decreases expression

Theophylline results in decreased expression of GRM1 protein

NCBI chr 1:6,878,542...7,273,447
Ensembl chr 1:5,058,292...5,453,170

G

glutamate metabotropic receptor 6

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of GRM6 protein

NCBI chr10:35,669,003...35,683,729
Ensembl chr10:35,167,985...35,182,717

G

glycogen synthase kinase 3 beta

increases phosphorylation

Theophylline results in increased phosphorylation of GSK3B protein

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646

G

glutathione-disulfide reductase

multiple interactions

Theophylline inhibits the reaction [Phenylisopropyladenosine results in increased expression of GSR protein]

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase mu 2

decreases expression

Theophylline results in decreased expression of GSTM2 mRNA

NCBI chr 2:198,312,179...198,316,962
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase, mu 5

decreases expression

Theophylline results in decreased expression of GSTM3 mRNA

NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:195,531,495...195,534,553

G

H2A clustered histone 18

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of H2AC18 protein

NCBI chr 2:186,497,271...186,497,865

G

hydroxyacyl-CoA dehydrogenase

decreases expression

Theophylline results in decreased expression of HADH mRNA

NCBI chr 2:222,462,049...222,504,446
Ensembl chr 2:219,787,927...219,830,353

G

histone deacetylase 1

increases activity
increases expression

Theophylline results in increased activity of HDAC1 protein
Theophylline results in increased expression of HDAC1 protein

PMID:12070353 PMID:15337792

NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:141,853,989...141,881,111

G

histone deacetylase 2

increases expression

Theophylline results in increased expression of HDAC2 protein

NCBI chr20:42,101,815...42,126,486
Ensembl chr20:40,548,250...40,571,609

G

histone deacetylase 3

increases activity

Theophylline results in increased activity of HDAC3 protein

NCBI chr18:30,021,847...30,041,061
Ensembl chr18:29,770,636...29,793,856

G

histidine decarboxylase

affects response to substance

HDC protein affects the susceptibility to Theophylline

NCBI chr 3:134,300,628...134,318,704
Ensembl chr 3:113,847,260...113,865,341

G

helicase, POLQ-like

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of HELQ protein

NCBI chr14:9,122,978...9,167,310
Ensembl chr14:8,818,592...8,862,960

G

HemK methyltransferase family member 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of HEMK1 protein

NCBI chr 8:116,878,317...116,889,342
Ensembl chr 8:107,999,644...108,010,256

G

3-hydroxyisobutyrate dehydrogenase

decreases expression

Theophylline results in decreased expression of HIBADH mRNA

NCBI chr 4:82,979,759...83,077,819
Ensembl chr 4:81,649,175...81,780,617

G

histidine triad nucleotide binding protein 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of HINT1 protein

NCBI chr10:39,490,225...39,493,970
Ensembl chr 4:92,100,973...92,101,568

G

histone cluster 1 H2a family member I like 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of H3C6 protein

NCBI chr17:41,996,216...41,997,128
Ensembl chr17:41,568,471...41,569,109

G

histocompatibility minor 13

affects binding

Theophylline binds to HM13 protein

NCBI chr 3:161,606,059...161,641,382
Ensembl chr 3:141,145,782...141,184,703

G

heterogeneous nuclear ribonucleoprotein H3

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of HNRNPH3 protein

NCBI chr20:25,619,540...25,624,397
Ensembl chr20:25,614,733...25,625,750

G

HPS4, biogenesis of lysosomal organelles complex 3 subunit 2

decreases expression

Theophylline results in decreased expression of HPS4 mRNA

NCBI chr12:49,924,444...49,955,201
Ensembl chr12:44,264,037...44,294,632

G

hydroxysteroid (17-beta) dehydrogenase 14

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of HSD17B14 protein

NCBI chr 1:105,165,695...105,176,045
Ensembl chr 1:96,029,284...96,039,883

G

heat shock protein family A (Hsp70) member 2

increases expression

Theophylline results in increased expression of HSPA2 mRNA

NCBI chr 6:100,864,172...100,866,946
Ensembl chr 6:95,128,350...95,131,287

G

HtrA serine peptidase 2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of HTRA2 protein

NCBI chr 4:117,114,631...117,117,793
Ensembl chr 4:115,556,916...115,560,095

G

HUS1 checkpoint clamp component

decreases expression

Theophylline results in decreased expression of HUS1 mRNA

NCBI chr14:87,902,458...87,917,221
Ensembl chr14:83,688,708...83,703,442

G

intercellular adhesion molecule 4, Landsteiner-Wiener blood group

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ICAM4 protein

NCBI chr 8:27,842,255...27,843,351
Ensembl chr 8:19,566,075...19,567,171

G

interactor of little elongation complex ELL subunit 2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ICE2 protein

NCBI chr 8:78,921,962...78,965,983
Ensembl chr 8:70,043,424...70,084,995

G

alpha-L-iduronidase

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of IDUA protein

NCBI chr14:1,175,994...1,203,913
Ensembl chr14:1,032,171...1,046,522

G

immediate early response 2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of IER2 protein

NCBI chr19:40,399,373...40,400,897
Ensembl chr19:23,494,184...23,499,211

G

interferon, alpha 1

decreases metabolic processing

IFNA1 protein results in decreased metabolism of Theophylline

NCBI chr 5:108,143,240...108,143,809
Ensembl chr 5:103,097,356...103,097,925

G

interferon gamma

decreases expression

Theophylline results in decreased expression of IFNG mRNA

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375

G

intraflagellar transport 122

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of IFT122 protein

NCBI chr 4:150,577,525...150,648,052
Ensembl chr 4:148,905,046...148,975,458

G

intraflagellar transport 57

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of IFT57 protein

NCBI chr11:64,528,349...64,593,545
Ensembl chr11:51,059,611...51,124,812

G

intraflagellar transport 88

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of IFT88 protein

NCBI chr15:35,685,678...35,786,875
Ensembl chr15:31,573,376...31,672,147

G

insulin-like growth factor binding protein 5

decreases expression

Theophylline results in decreased expression of IGFBP5 mRNA

NCBI chr 9:81,901,605...81,914,187
Ensembl chr 9:74,448,382...74,465,156

G

Indian hedgehog signaling molecule

increases expression

Theophylline results in increased expression of IHH mRNA

NCBI chr 9:83,952,986...83,959,203
Ensembl chr 9:76,504,315...76,510,532

G

IKBKB interacting protein

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of IKBIP protein

NCBI chr 7:27,467,097...27,485,776
Ensembl chr 7:25,579,832...25,605,162

G

interleukin 10

decreases secretion

Theophylline results in decreased secretion of IL10 protein

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313

G

interleukin 12A

multiple interactions

Theophylline results in decreased expression of [IL12A protein binds to IL12B protein]

NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:152,965,769...152,972,734

G

interleukin 12B

multiple interactions
decreases expression

Theophylline results in decreased expression of [IL12A protein binds to IL12B protein]
Theophylline results in decreased expression of IL12B protein

NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903

G

interleukin 13

decreases expression
decreases secretion

Theophylline results in decreased expression of IL13 mRNA; Theophylline results in decreased expression of IL13 protein
Theophylline results in decreased secretion of IL13 protein

NCBI chr10:38,290,926...38,293,483
Ensembl chr10:37,790,130...37,792,737

G

interleukin 18

multiple interactions

Theophylline inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein]]]; Theophylline inhibits the reaction [Tobacco Smoke Pollution inhibits the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein]]]

NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 beta

multiple interactions

Theophylline inhibits the reaction [Indomethacin results in increased expression of IL1B protein]
[Theophylline co-treated with Dexamethasone] inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]; Theophylline inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Budesonide inhibits the reaction [IL1B protein results in increased acetylation of H4C16 protein]]]; Theophylline promotes the reaction [Dexamethasone inhibits the reaction [Hydrogen Peroxide promotes the reaction [IL1B protein results in increased secretion of CXCL8 protein]]]; Theophylline promotes the reaction [IL1B protein results in increased secretion of CSF2 protein]; trichostatin A inhibits the reaction [[Theophylline co-treated with Dexamethasone] inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]]

PMID:12070353 PMID:15337792 PMID:16133968 PMID:18951874

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

increases secretion

Theophylline results in increased secretion of IL2 protein

NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 2 receptor subunit alpha

decreases expression

Theophylline results in decreased expression of IL2RA protein

NCBI chr17:71,759,802...71,808,475
Ensembl chr17:66,849,974...66,898,697

G

interleukin 3

decreases expression

Theophylline results in decreased expression of IL3 mRNA

NCBI chr10:38,906,460...38,908,810
Ensembl chr10:38,405,716...38,408,066

G

interleukin 4

multiple interactions
decreases expression
decreases secretion

IL4 protein inhibits the reaction [[Theophylline co-treated with Chlorambucil] results in increased expression of MYC protein]; IL4 protein inhibits the reaction [[Theophylline co-treated with Chlorambucil] results in increased expression of TP53]; IL4 protein inhibits the reaction [Theophylline results in decreased expression of BCL2 protein]
Theophylline results in decreased expression of IL4 mRNA
Theophylline results in decreased secretion of IL4 protein

PMID:8822937 PMID:10596698 PMID:11694023

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

multiple interactions
increases expression

[Albuterol co-treated with Theophylline] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; [Bucladesine co-treated with Theophylline] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; [Dinoprostone co-treated with Theophylline] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; [Theophylline co-treated with Albuterol] inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Theophylline inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Theophylline inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Theophylline inhibits the reaction [TNF protein results in increased expression of IL6 protein]
Theophylline results in increased expression of IL6 mRNA

PMID:11770011 PMID:16083514 PMID:20388727

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 6 receptor

decreases expression

Theophylline results in decreased expression of IL6R mRNA

NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:175,298,686...175,347,536

G

interleukin 6 cytokine family signal transducer

increases expression

Theophylline results in increased expression of IL6ST mRNA

NCBI chr 2:45,798,872...45,839,501
Ensembl chr 2:44,066,130...44,109,936

G

integrin-linked kinase

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ILK protein

NCBI chr 1:169,500,716...169,506,972
Ensembl chr 1:160,088,897...160,095,140

G

INTS3 and NABP interacting protein

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of INIP protein

NCBI chr 5:79,443,317...79,457,552
Ensembl chr 5:74,648,392...74,662,628

G

insulin 1

multiple interactions

[Theophylline co-treated with INS1 protein] results in decreased abundance of Cyclic AMP; INS1 protein inhibits the reaction [[Theophylline co-treated with Norepinephrine] results in increased abundance of Cyclic AMP]; INS1 protein inhibits the reaction [[Theophylline co-treated with POMC protein] results in increased abundance of Cyclic AMP]

NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536

G

interferon regulatory factor 7

decreases expression

Theophylline results in decreased expression of IRF7 mRNA

NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:196,367,361...196,370,832

G

insulin receptor substrate 1

increases expression

Theophylline results in increased expression of IRS1 mRNA

NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:83,548,944...83,606,122

G

integrin alpha FG-GAP repeat containing 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ITFG1 protein

NCBI chr19:21,210,697...21,331,285
Ensembl chr19:21,210,733...21,331,279

G

integrin subunit alpha M

multiple interactions

Isoproterenol promotes the reaction [Theophylline inhibits the reaction [Platelet Activating Factor results in increased expression of ITGAM protein]]; Theophylline inhibits the reaction [Platelet Activating Factor results in increased expression of ITGAM protein]

NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:182,659,000...182,709,503

G

integrin subunit beta 2

increases expression

Theophylline results in increased expression of ITGB2 mRNA

NCBI chr20:11,061,009...11,097,242
Ensembl chr20:11,061,430...11,097,600

G

integral membrane protein 2B

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ITM2B protein

NCBI chr15:54,955,549...54,978,455
Ensembl chr15:48,546,001...48,568,917

G

jade family PHD finger 1

increases expression

Theophylline results in increased expression of JADE1 mRNA

NCBI chr 2:126,471,124...126,524,252
Ensembl chr 2:124,543,286...124,596,354

G

Janus kinase 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of JAK1 protein

NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:115,780,248...115,888,926

G

potassium voltage-gated channel subfamily C member 3

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of KCNC3 protein

NCBI chr 1:104,217,472...104,231,677
Ensembl chr 1:95,080,960...95,095,160

G

potassium calcium-activated channel subfamily M regulatory beta subunit 4

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of KCNMB4 protein

NCBI chr 7:53,952,150...54,005,101
Ensembl chr 7:52,066,136...52,119,278

G

lysine demethylase 4B

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of KDM4B protein

NCBI chr 9:1,245,885...1,324,384
Ensembl chr 9:1,158,752...1,236,543

G

lysine demethylase 6B

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of KDM6B protein

NCBI chr10:54,619,520...54,641,014
Ensembl chr10:54,121,848...54,130,794

G

kinesin family member 1B

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of KIF1B protein

NCBI chr 5:164,890,778...165,025,848
Ensembl chr 5:159,561,271...159,742,778

G

Kin17 DNA and RNA binding protein

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of KIN protein

NCBI chr17:73,323,189...73,333,542
Ensembl chr17:68,413,486...68,423,845

G

kelch-like family member 7

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of KLHL7 protein

NCBI chr 4:11,898,766...11,947,796
Ensembl chr 4:11,006,375...11,055,541

G

keratin 8

increases expression

Theophylline results in increased expression of KRT8 mRNA

NCBI chr 7:135,002,886...135,010,339
Ensembl chr 7:133,124,203...133,131,728

G

laminin subunit gamma 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of LAMC1 protein

NCBI chr13:67,924,872...68,051,986
Ensembl chr13:65,374,372...65,501,492

G

lipopolysaccharide binding protein

increases expression

Theophylline results in increased expression of LBP mRNA

NCBI chr 3:167,373,786...167,400,941
Ensembl chr 3:146,954,015...146,981,586

G

leucine zipper and EF-hand containing transmembrane protein 2

decreases expression

Theophylline results in decreased expression of LETM2 mRNA

NCBI chr16:73,171,768...73,192,336
Ensembl chr16:66,469,111...66,489,704

G

galectin 3

increases expression

Theophylline results in increased expression of LGALS3 mRNA

NCBI chr15:23,099,795...23,111,731
Ensembl chr15:20,607,692...20,632,025

G

LHFPL tetraspan subfamily member 6

multiple interactions
decreases expression

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of LHFPL6 protein
Theophylline results in decreased expression of LHFPL6 mRNA

NCBI chr 2:139,276,810...139,474,740
Ensembl chr 2:137,126,509...137,324,443

G

LIM domain kinase 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of LIMK1 protein

NCBI chr12:27,663,177...27,697,085
Ensembl chr12:22,026,672...22,060,606

G

lipase C, hepatic type

decreases expression

Theophylline results in decreased expression of LIPC mRNA

NCBI chr 8:80,390,470...80,516,463
Ensembl chr 8:71,509,635...71,635,464

G

lipase E, hormone sensitive type

multiple interactions
affects localization
increases activity

Theophylline inhibits the reaction [Epinephrine results in increased activity of LIPE protein]
Theophylline affects the localization of LIPE protein
Theophylline results in increased activity of LIPE protein

PMID:7155675 PMID:11160373

NCBI chr 1:90,093,433...90,112,117
Ensembl chr 1:80,965,627...80,984,310

G

lipoprotein lipase

increases expression

Theophylline results in increased expression of LPL mRNA

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:20,829,465...20,855,249

G

leucine rich repeat containing 23

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of LRRC23 protein

NCBI chr 4:159,267,572...159,277,764
Ensembl chr 4:157,581,291...157,591,860

G

LSM8 homolog, U6 small nuclear RNA associated

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of LSM8 protein

NCBI chr 4:48,272,128...48,277,994
Ensembl chr 4:47,306,295...47,314,293

G

leukocyte specific transcript 1

increases expression

Theophylline results in increased expression of LST1 mRNA

NCBI chr20:3,639,353...3,644,399
Ensembl chr20:3,634,749...3,637,997

G

lymphotoxin beta

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of LTB protein

NCBI chr20:3,632,209...3,634,054
Ensembl chr20:3,627,537...3,629,381

G

leukotriene C4 synthase

decreases secretion

Theophylline results in decreased secretion of LTC4S protein

NCBI chr10:35,060,002...35,066,466
Ensembl chr10:34,560,360...34,562,651

G

lactotransferrin

decreases expression

Theophylline results in decreased expression of LTF protein

NCBI chr 8:119,878,344...119,901,189
Ensembl chr 8:110,999,948...111,022,795

G

lysophospholipase-like 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of LYPLAL1 protein

NCBI chr13:100,158,060...100,189,339
Ensembl chr13:97,626,451...97,657,867

G

mitogen activated protein kinase 1

increases phosphorylation

Theophylline results in increased phosphorylation of MAPK1 protein

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen-activated protein kinase 1 interacting protein 1-like

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of MAPK1IP1L protein

NCBI chr15:23,024,757...23,051,189
Ensembl chr15:20,545,059...20,569,674

G

mitogen activated protein kinase 3

increases phosphorylation

Theophylline results in increased phosphorylation of MAPK3 protein

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 7

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of MAPK7 protein

NCBI chr10:46,669,721...46,675,768
Ensembl chr10:46,170,167...46,176,267

G

malate dehydrogenase 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of MDH1 protein

NCBI chr14:99,831,934...99,847,227
Ensembl chr14:95,630,306...95,645,925

G

MDS1 and EVI1 complex locus

increases expression

Theophylline results in increased expression of MECOM mRNA

NCBI chr 2:114,837,815...115,393,052
Ensembl chr 2:112,909,321...113,464,590

G

mediator complex subunit 13L

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of MED13L protein

NCBI chr12:43,468,556...43,665,819
Ensembl chr12:37,808,285...38,004,473

G

mediator complex subunit 16

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of MED16 protein

NCBI chr 7:10,449,273...10,461,797
Ensembl chr 7:9,798,668...9,811,172

G

myocyte enhancer factor 2a

decreases expression

Theophylline results in decreased expression of MEF2A mRNA

NCBI chr 1:130,258,083...130,392,819
Ensembl chr 1:120,850,080...120,981,948

G

methyltransferase 15, mitochondrial 12S rRNA N4-cytidine

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of METTL15 protein

NCBI chr 3:116,041,480...116,219,011
Ensembl chr 3:95,586,850...95,764,397

G

major facilitator superfamily domain containing 10

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of MFSD10 protein

NCBI chr14:80,327,961...80,331,984
Ensembl chr14:76,103,815...76,107,377

G

microsomal glutathione S-transferase 2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of MGST2 protein

NCBI chr 2:137,821,787...137,866,664
Ensembl chr 2:135,693,557...135,715,828

G

mast cell immunoglobulin-like receptor 1

decreases expression

Theophylline results in decreased expression of MILR1 mRNA

NCBI chr10:92,184,002...92,205,001
Ensembl chr10:91,687,831...91,705,282

G

melanocyte inducing transcription factor

increases expression

Theophylline results in increased expression of MITF protein

NCBI chr 4:131,965,676...132,177,790
Ensembl chr 4:130,409,217...130,621,145

G

metabolism of cobalamin associated B

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of MMAB protein

NCBI chr12:47,819,757...47,833,127
Ensembl chr12:42,159,089...42,172,490

G

MON1 homolog B, secretory trafficking associated

decreases expression

Theophylline results in decreased expression of MON1B mRNA

NCBI chr19:58,526,503...58,534,478
Ensembl chr19:41,617,364...41,625,347

G

modulator of smoothened

increases expression

Theophylline results in increased expression of MOSMO mRNA

NCBI chr 1:184,648,985...184,719,820
Ensembl chr 1:175,217,545...175,288,334

G

M phase phosphoprotein 6

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of MPHOSPH6 protein

NCBI chr19:62,768,909...62,778,874
Ensembl chr19:45,860,154...45,870,170

G

myeloperoxidase

decreases expression
multiple interactions

Theophylline results in decreased expression of MPO protein
Theophylline inhibits the reaction [Indomethacin results in increased activity of MPO protein]

PMID:12016098 PMID:16133968

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819

G

mitochondrial ribosome-associated GTPase 2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of MTG2 protein

NCBI chr 3:187,543,166...187,558,973
Ensembl chr 3:167,165,982...167,181,358

G

mitochondrial translational initiation factor 3

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of MTIF3 protein

NCBI chr12:13,240,091...13,251,350
Ensembl chr12:8,126,276...8,140,470

G

mitochondrial tRNA translation optimization 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of MTO1 protein

NCBI chr 8:79,309,681...79,335,231
Ensembl chr 8:79,309,982...79,335,231

G

mucin 5B, oligomeric mucus/gel-forming

decreases expression

Theophylline results in decreased expression of MUC5B mRNA

NCBI chr 1:206,346,400...206,378,367
Ensembl chr 1:196,916,825...196,949,250

G

murinoglobulin 1

decreases expression

Theophylline results in decreased expression of MUG1 mRNA

NCBI chr 4:156,748,351...156,802,132
Ensembl chr 4:155,076,312...155,130,051

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions
decreases expression
affects expression
increases expression

[Theophylline co-treated with Chlorambucil] results in increased expression of MYC protein; IL4 protein inhibits the reaction [[Theophylline co-treated with Chlorambucil] results in increased expression of MYC protein]
Theophylline results in decreased expression of MYC mRNA
Theophylline affects the expression of MYC mRNA
Theophylline results in increased expression of MYC mRNA mutant form; Theophylline results in increased expression of MYC protein

PMID:8416737 PMID:8822937 PMID:17522070

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630

G

myosin XIX

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of MYO19 protein

NCBI chr10:70,250,500...70,279,867
Ensembl chr10:69,753,068...69,782,450

G

mitotic spindle organizing protein 1

decreases expression

Theophylline results in decreased expression of MZT1 mRNA

NCBI chr15:82,195,128...82,205,436
Ensembl chr15:75,786,994...75,797,589

G

NEDD4 binding protein 2-like 2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of N4BP2L2 protein

NCBI chr12:4,972,967...5,038,027
Ensembl chr12:103,590...197,784

G

NACC family member 2

increases expression

Theophylline results in increased expression of NACC2 mRNA

NCBI chr 3:29,278,077...29,345,098
Ensembl chr 3:8,883,065...8,946,660

G

N-acyl phosphatidylethanolamine phospholipase D

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of NAPEPLD protein

NCBI chr 4:14,251,591...14,291,010
Ensembl chr 4:13,361,006...13,398,748

G

neurobeachin-like 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of NBEAL1 protein

NCBI chr 9:69,069,326...69,237,932
Ensembl chr 9:61,575,356...61,736,750

G

NCK adaptor protein 2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of NCK2 protein

NCBI chr 9:53,206,006...53,332,417
Ensembl chr 9:45,714,883...45,840,307

G

NADH:ubiquinone oxidoreductase subunit B2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of NDUFB2 protein

NCBI chr 4:69,334,307...69,341,394
Ensembl chr15:46,536,062...46,536,851
Ensembl chr 4:46,536,062...46,536,851

G

NEDD4 like E3 ubiquitin protein ligase

increases expression

Theophylline results in increased expression of NEDD4L mRNA

NCBI chr18:60,663,918...60,996,824
Ensembl chr18:58,393,509...58,723,137

G

nuclear factor kappa B subunit 1

multiple interactions

Theophylline inhibits the reaction [TNF protein affects the localization of NFKB1 protein]

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

affects expression
decreases degradation

Theophylline affects the expression of NFKBIA protein
Theophylline results in decreased degradation of NFKBIA protein

PMID:11770011 PMID:12065913

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941

G

NKAP domain containing 1

increases expression

Theophylline results in increased expression of NKAPD1 mRNA

NCBI chr 8:59,852,037...59,863,295
Ensembl chr 8:50,955,654...50,966,830

G

nemo like kinase

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of NLK protein

NCBI chr10:63,965,432...64,089,006
Ensembl chr10:63,438,222...63,589,730

G

nicotinamide nucleotide transhydrogenase

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of NNT protein

NCBI chr 2:53,144,157...53,237,857
Ensembl chr 2:51,411,413...51,504,823

G

NOP10 ribonucleoprotein

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of NOLA3 protein

NCBI chr 3:119,521,255...119,522,340
Ensembl chr 3:99,066,857...99,067,942

G

nitric oxide synthase 2

multiple interactions

Theophylline inhibits the reaction [Indomethacin results in increased expression of NOS2 protein]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210

G

N-ribosyldihydronicotinamide:quinone dehydrogenase 2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of NQO2 protein

NCBI chr17:31,114,825...31,144,062
Ensembl chr17:30,909,187...30,938,320

G

neuronal regeneration related protein

decreases expression

Theophylline results in decreased expression of NREP mRNA

NCBI chr18:25,291,219...25,320,742
Ensembl chr18:25,017,083...25,046,591

G

neurexin 3

increases expression

Theophylline results in increased expression of NRXN3 mRNA

NCBI chr 6:113,372,667...115,004,073
Ensembl chr 6:107,641,780...109,272,044

G

NS5A transactivated protein 4

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of C1ORF43 protein

NCBI chr 2:177,792,070...177,804,943
Ensembl chr 2:175,494,304...175,510,663

G

nuclear receptor binding SET domain protein 3

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of NSD3 protein

NCBI chr16:73,056,748...73,170,082
Ensembl chr16:66,358,973...66,465,423

G

NOP2/Sun RNA methyltransferase 4

increases expression

Theophylline results in increased expression of NSUN4 mRNA

NCBI chr 5:134,749,024...134,773,630
Ensembl chr 5:129,512,307...129,532,423
Ensembl chr 5:129,512,307...129,532,423

G

N-terminal glutamine amidase 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of NTAQ1 protein

NCBI chr 7:91,573,816...91,593,980
Ensembl chr 7:89,684,323...89,704,474

G

neurotensin

multiple interactions

Theophylline inhibits the reaction [Haloperidol results in increased expression of NTS mRNA]

NCBI chr 7:39,451,484...39,460,888
Ensembl chr 7:37,564,533...37,574,423

G

nucleoporin 50

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of NUP50 protein

NCBI chr 7:117,927,882...117,945,155
Ensembl chr 7:116,048,021...116,066,905

G

nuclear transport factor 2

increases expression

Theophylline results in increased expression of NUTF2 mRNA

NCBI chr19:50,662,168...50,683,457
Ensembl chr19:33,752,291...33,773,591

G

OCIA domain containing 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of OCIAD1 protein

NCBI chr14:35,251,891...35,269,440
Ensembl chr14:34,897,847...34,915,286

G

olfactory receptor family 4 subfamily N member 4

increases expression

Theophylline results in increased expression of OR4N4 mRNA

NCBI chr15:25,968,149...25,969,140
Ensembl chr15:23,492,445...23,498,563

G

oxysterol binding protein

increases expression

Theophylline results in increased expression of OSBP mRNA

NCBI chr 1:218,313,455...218,343,263
Ensembl chr 1:208,887,895...208,918,506

G

ornithine transcarbamylase

decreases expression

Theophylline results in decreased expression of OTC mRNA

NCBI chr X:15,126,358...15,202,473
Ensembl chr X:12,453,834...12,566,918

G

orthopedia homeobox

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of OTP protein; [Hydrogen Peroxide co-treated with Theophylline] results in increased expression of OTP protein

NCBI chr 2:27,842,892...27,851,093
Ensembl chr 2:26,108,163...26,116,359

G

poly(A) specific ribonuclease subunit PAN3

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PAN3 protein

NCBI chr12:12,512,835...12,637,066
Ensembl chr12:7,476,697...7,599,204

G

poly (ADP-ribose) polymerase 1

affects binding
multiple interactions

Theophylline binds to PARP1 protein
[Colforsin co-treated with Theophylline] inhibits the reaction [Etoposide results in increased cleavage of PARP1 protein]

PMID:9454737 PMID:18951874

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404

G

polybromo 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PB1 protein

NCBI chr16:6,219,933...6,319,336
Ensembl chr16:6,213,300...6,311,780

G

Purkinje cell protein 4-like 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PCP4L1 protein

NCBI chr13:86,121,463...86,145,097
Ensembl chr13:83,588,992...83,609,966

G

proprotein convertase subtilisin/kexin type 5

increases expression

Theophylline results in increased expression of PCSK5 mRNA

NCBI chr 1:224,263,823...224,694,350
Ensembl chr 1:214,837,927...215,267,600

G

phosphodiesterase 3A

increases expression

Theophylline results in increased expression of PDE3A mRNA

NCBI chr 4:175,904,276...176,170,531
Ensembl chr 4:174,172,868...174,438,274

G

decaprenyl diphosphate synthase subunit 2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PDSS2 protein

NCBI chr20:48,291,788...48,520,846
Ensembl chr20:46,709,649...46,938,708

G

proliferation and apoptosis adaptor protein 15

decreases expression

Theophylline results in decreased expression of PEA15 mRNA

NCBI chr13:87,190,189...87,199,811
Ensembl chr13:84,654,870...84,667,499

G

peroxisomal biogenesis factor 7

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of PEX7 protein

NCBI chr 1:16,402,319...16,466,304
Ensembl chr 1:14,582,699...14,646,748

G

protein inhibitor of activated STAT, 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PIAS1 protein

NCBI chr 8:72,233,566...72,347,085
Ensembl chr 8:63,338,150...63,438,905

G

protein inhibitor of activated STAT, 2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PIAS2 protein

NCBI chr18:72,883,008...72,989,486
Ensembl chr18:70,607,665...70,710,033

G

phosphatidylinositol binding clathrin assembly protein

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PICALM protein

NCBI chr 1:153,468,982...153,550,086
Ensembl chr 1:144,056,721...144,137,557

G

phosphatidylinositol glycan anchor biosynthesis, class C

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PIGC protein

NCBI chr13:76,876,894...76,879,420
Ensembl chr13:74,296,854...74,346,211

G

pipecolic acid and sarcosine oxidase

decreases expression

Theophylline results in decreased expression of PIPOX mRNA

NCBI chr10:63,267,946...63,281,556
Ensembl chr10:62,769,900...62,782,370

G

phosphatidylinositol transfer protein, beta

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PITPNB protein

NCBI chr12:50,909,140...50,958,193
Ensembl chr12:45,249,333...45,298,314

G

PKHD1 ciliary IPT domain containing fibrocystin/polyductin

decreases expression

Theophylline results in decreased expression of PKHD1 mRNA

NCBI chr 9:30,040,466...30,533,834
Ensembl chr 9:22,549,513...23,037,381

G

pyruvate kinase L/R

decreases expression

Theophylline results in decreased expression of PKLR mRNA

NCBI chr 2:176,840,779...176,849,637
Ensembl chr 2:174,543,039...174,551,870

G

phospholipase C beta 1

multiple interactions
decreases expression

Theophylline inhibits the reaction [3,4-dihydroxyphenylglycol results in increased activity of PLCB1 protein]; Theophylline inhibits the reaction [[3,4-dihydroxyphenylglycol co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] results in increased activity of PLCB1 protein]; Theophylline inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of PLCB1 protein]
Theophylline results in decreased expression of PLCB1 protein

NCBI chr 3:142,512,765...143,224,042
Ensembl chr 3:122,060,031...122,772,869

G

phospholipase D family, member 3

increases expression

Theophylline results in increased expression of PLD3 mRNA

NCBI chr 1:91,949,465...91,971,834
Ensembl chr 1:82,821,875...82,844,072

G

pleckstrin homology domain containing A1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of PLEKHA1 protein

NCBI chr 1:194,858,239...194,909,418
Ensembl chr 1:185,428,048...185,479,156

G

pleiotropic regulator 1

increases expression

Theophylline results in increased expression of PLRG1 mRNA

NCBI chr 2:170,706,188...170,722,519
Ensembl chr 2:168,408,124...168,424,522

G

RNA polymerase I subunit B

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of POLR1B protein

NCBI chr 3:136,787,130...136,811,608
Ensembl chr 3:116,333,889...116,358,379

G

RNA polymerase II, I and III subunit F

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of POLR2F protein

NCBI chr 7:112,592,977...112,604,681
Ensembl chr 7:110,712,572...110,724,234

G

RNA polymerase III subunit H

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of POLR3H protein

NCBI chr 7:115,309,571...115,319,881
Ensembl chr 7:113,429,451...113,439,778

G

RNA polymerase III subunit K

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of POLR3K protein

NCBI chr 3:189,360,349...189,364,546
Ensembl chr 3:168,982,812...168,987,040

G

proopiomelanocortin

multiple interactions

[Theophylline co-treated with POMC protein] results in increased abundance of Cyclic AMP; INS1 protein inhibits the reaction [[Theophylline co-treated with POMC protein] results in increased abundance of Cyclic AMP]

NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:26,939,837...26,945,664

G

paraoxonase 1

decreases activity

Theophylline results in decreased activity of PON1 protein

NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:33,294,722...33,321,360

G

peroxisome proliferator activated receptor alpha

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of PPARA protein

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor gamma

increases expression

Theophylline results in increased expression of PPARG mRNA; Theophylline results in increased expression of PPARG protein

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468

G

protein phosphatase 2 catalytic subunit alpha

decreases expression

Theophylline results in decreased expression of PPP2CA mRNA

NCBI chr10:36,856,534...36,878,789
Ensembl chr10:36,358,101...36,377,862

G

protein phosphatase 3 catalytic subunit beta

decreases expression

Theophylline results in decreased expression of PPP3CB mRNA

NCBI chr15:3,809,182...3,854,204
Ensembl chr15:3,760,030...3,804,981

G

protein phosphatase 4, regulatory subunit 3B

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of PPP4R3B protein

NCBI chr14:107,118,116...107,166,121
Ensembl chr14:102,917,443...103,068,192

G

DNA primase subunit 2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PRIM2 protein

NCBI chr 9:43,188,350...43,400,482
Ensembl chr 9:35,692,376...35,903,030

G

protein kinase AMP-activated catalytic subunit alpha 1

decreases expression

Theophylline results in decreased expression of PRKAA1 mRNA

NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:54,240,137...54,275,978

G

protein kinase cAMP-activated catalytic subunit alpha

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of PRKACA protein

NCBI chr19:41,059,843...41,083,189
Ensembl chr19:24,155,090...24,178,430

G

protein kinase C, alpha

decreases expression

Theophylline results in decreased expression of PRKCA mRNA

NCBI chr10:93,388,991...93,787,617
Ensembl chr10:92,894,012...93,288,012

G

protein activator of interferon induced protein kinase EIF2AK2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PRKRA protein

NCBI chr 3:81,982,669...82,002,028
Ensembl chr 3:61,575,447...61,594,347

G

prolactin receptor

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of PRLR protein

NCBI chr 2:60,861,391...61,051,883
Ensembl chr 2:59,134,588...59,324,718

G

proline and serine rich 3

increases expression

Theophylline results in increased expression of PROSER3 mRNA

NCBI chr 1:94,920,802...94,934,126
Ensembl chr 1:85,793,358...85,805,909

G

pre-mRNA processing factor 38B

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PRPF38B protein

NCBI chr 2:199,241,312...199,250,342
Ensembl chr 2:196,553,225...196,562,250

G

proteasome 20S subunit beta 1

affects expression

Theophylline affects the expression of PSMB1 mRNA

NCBI chr 1:65,115,770...65,136,516
Ensembl chr 1:56,420,618...56,463,560

G

proteasome 20S subunit beta 10

affects expression

Theophylline affects the expression of PSMB10 mRNA

NCBI chr19:50,740,808...50,743,292
Ensembl chr19:33,827,229...33,833,626

G

proteasome 20S subunit beta 2

affects expression

Theophylline affects the expression of PSMB2 mRNA

NCBI chr 5:144,255,058...144,287,200
Ensembl chr 5:138,970,533...139,021,137

G

proteasome 20S subunit beta 5

affects expression

Theophylline affects the expression of PSMB5 mRNA

NCBI chr15:32,042,784...32,047,379
Ensembl chr15:28,072,781...28,077,440

G

proteasome 20S subunit beta 8

affects expression

Theophylline affects the expression of PSMB8 mRNA

NCBI chr20:4,654,068...4,657,049
Ensembl chr20:4,652,159...4,655,283

G

proteasome 20S subunit beta 9

affects expression

Theophylline affects the expression of PSMB9 mRNA

NCBI chr20:4,668,952...4,674,421
Ensembl chr20:4,666,046...4,672,512

G

parathyroid hormone

multiple interactions
increases expression

Calcifediol inhibits the reaction [Theophylline results in increased expression of PTH protein]

NCBI chr 1:176,942,901...176,946,034
Ensembl chr 1:167,508,598...167,511,530

G

prothymosin alpha

decreases expression

Theophylline results in decreased expression of PTMA mRNA

NCBI chr 9:94,624,194...94,628,276
Ensembl chr 9:87,176,230...87,180,333

G

protein tyrosine phosphatase 4A1

decreases expression

Theophylline results in decreased expression of PTP4A1 mRNA

NCBI chr 9:40,710,250...40,718,176
Ensembl chr 9:33,214,208...33,221,964

G

protein tyrosine phosphatase, non-receptor type 2

increases expression

Theophylline results in increased expression of PTPN2 mRNA

NCBI chr18:63,498,890...63,564,571
Ensembl chr18:61,229,014...61,294,627

G

protein tyrosine phosphatase, receptor type, E

increases expression

Theophylline results in increased expression of PTPRE mRNA

NCBI chr 1:199,774,195...199,924,646
Ensembl chr 1:190,344,401...190,489,534

G

pyrroline-5-carboxylate reductase 2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of PYCR2 protein

NCBI chr13:95,158,236...95,162,030
Ensembl chr13:92,626,471...92,634,184

G

RAB11B, member RAS oncogene family

increases expression

Theophylline results in increased expression of RAB11B mRNA

NCBI chr 7:15,223,613...15,236,754
Ensembl chr 7:14,521,368...14,534,593

G

RAB21, member RAS oncogene family

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of RAB21 protein

NCBI chr 7:52,790,158...52,814,943
Ensembl chr 7:50,904,057...50,928,839

G

RAD9 checkpoint clamp component A

decreases expression

Theophylline results in decreased expression of RAD9A mRNA

NCBI chr 1:210,917,970...210,983,038
Ensembl chr 1:201,487,136...201,553,608

G

RAN guanine nucleotide release factor

increases expression

Theophylline results in increased expression of RANGRF mRNA

NCBI chr10:54,176,325...54,177,696
Ensembl chr10:53,677,467...53,678,840

G

RAS protein activator like 2

decreases expression

Theophylline results in decreased expression of RASAL2 mRNA

NCBI chr13:71,808,740...72,102,723
Ensembl chr13:69,258,622...69,569,940

G

RB transcriptional corepressor 1

multiple interactions

[Colforsin co-treated with Theophylline] inhibits the reaction [Etoposide results in decreased phosphorylation of RB1 protein]; [Hydrogen Peroxide co-treated with Theophylline] results in increased expression of RB1 protein

PMID:9454737 PMID:18951874

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302

G

RNA binding motif protein 8A

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of RBM8A protein

NCBI chr 2:186,854,018...186,856,802
Ensembl chr 2:184,165,193...184,167,959

G

ring finger and CCCH-type domains 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of RC3H1 protein

NCBI chr13:75,707,098...75,779,114
Ensembl chr13:73,173,946...73,238,839

G

regulator of calcineurin 1

increases expression

Theophylline results in increased expression of RCAN1 mRNA

NCBI chr11:45,108,123...45,188,065
Ensembl chr11:31,622,210...31,702,045

G

RCC1 like

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of RCC1L protein

NCBI chr12:28,179,205...28,210,462
Ensembl chr12:22,543,734...22,574,036

G

retinol dehydrogenase 10

increases expression

Theophylline results in increased expression of RDH10 mRNA

NCBI chr 5:7,969,931...7,998,834
Ensembl chr 5:3,188,445...3,215,572

G

reversion-inducing-cysteine-rich protein with kazal motifs

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of RECK protein

NCBI chr 5:62,898,717...62,965,274
Ensembl chr 5:58,102,981...58,169,502

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
affects localization

Theophylline inhibits the reaction [TNF protein results in increased expression of RELA protein]
Theophylline affects the localization of RELA protein

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484

G

renin

affects expression

Theophylline affects the expression of REN protein

NCBI chr13:47,348,312...47,359,539
Ensembl chr13:44,796,091...44,807,489

G

riboflavin kinase

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of RFK protein

NCBI chr 1:224,226,632...224,234,185
Ensembl chr 1:214,799,825...214,807,438
Ensembl chr X:214,799,825...214,807,438

G

raftlin lipid raft linker 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of RFTN1 protein

NCBI chr 9:18,302,143...18,499,819
Ensembl chr 9:10,804,611...11,002,084

G

regulatory factor X, 7

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of RFX7 protein

NCBI chr 8:82,134,747...82,219,898
Ensembl chr 8:73,254,051...73,339,209

G

regulator of G-protein signaling 16

increases expression

Theophylline results in increased expression of RGS16 mRNA

NCBI chr13:68,421,480...68,443,312
Ensembl chr13:65,887,530...65,892,857

G

RAD9-HUS1-RAD1 interacting nuclear orphan 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of RHNO1 protein

NCBI chr 4:163,320,141...163,325,527
Ensembl chr 4:161,634,048...161,639,371

G

ras homolog family member T2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of RHOT2 protein

NCBI chr10:15,363,467...15,369,263
Ensembl chr10:14,858,956...14,864,751

G

RIC3 acetylcholine receptor chaperone

affects binding

Theophylline binds to RIC3 protein

NCBI chr 1:172,465,638...172,521,349
Ensembl chr 1:163,032,158...163,086,519

G

RIO kinase 3

decreases expression

Theophylline results in decreased expression of RIOK3 mRNA

NCBI chr18:3,602,535...3,628,108
Ensembl chr18:3,327,776...3,353,343

G

receptor-interacting serine-threonine kinase 3

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of RIPK3 protein

NCBI chr15:33,253,071...33,262,025
Ensembl chr15:29,283,145...29,292,121

G

required for meiotic nuclear division 5 homolog A

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of RMND5A protein

NCBI chr 4:104,934,160...104,991,088
Ensembl chr 4:103,379,908...103,433,051

G

ribonuclease T2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of RNASET2 protein

NCBI chr 1:55,133,532...55,150,701
Ensembl chr 1:52,585,929...52,603,147

G

ribosomal protein S15

decreases expression

Theophylline results in decreased expression of RPS15 mRNA

NCBI chr 7:10,066,572...10,068,167
Ensembl chr 7:9,416,004...9,417,450
Ensembl chr 7:9,416,004...9,417,450

G

somatomedin B and thrombospondin, type 1 domain containing

decreases expression

Theophylline results in decreased expression of SBSPON mRNA

NCBI chr 5:8,186,004...8,216,576
Ensembl chr 5:3,402,648...3,435,420

G

serine dehydratase

increases expression

Theophylline results in increased expression of SDS mRNA

NCBI chr12:41,743,796...41,751,108
Ensembl chr12:36,083,229...36,088,203

G

SECIS binding protein 2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SECISBP2 protein

NCBI chr17:13,690,263...13,721,303
Ensembl chr17:13,538,513...13,569,523

G

selectin L

multiple interactions

Isoproterenol promotes the reaction [Theophylline inhibits the reaction [Platelet Activating Factor results in increased secretion of SELL protein]]; Theophylline inhibits the reaction [Platelet Activating Factor results in increased secretion of SELL protein]

NCBI chr13:78,950,100...78,969,604
Ensembl chr13:76,416,915...76,436,456

G

serpin family A member 1

affects response to substance

SERPINA1 gene affects the susceptibility to Theophylline

NCBI chr 6:128,631,101...128,653,125
Ensembl chr 6:122,866,312...122,888,339

G

SET domain containing 2, histone lysine methyltransferase

decreases expression

Theophylline results in decreased expression of SETD2 mRNA

NCBI chr 8:119,390,207...119,475,863
Ensembl chr 8:110,511,772...110,597,489

G

surfactant protein B

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SFTPB protein

NCBI chr 4:105,917,495...105,926,631
Ensembl chr 4:104,359,396...104,368,436

G

SH2 domain containing 2A

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of SH2D2A protein

NCBI chr 2:175,610,127...175,616,685
Ensembl chr 2:173,312,253...173,318,810

G

SH3 domain containing ring finger 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SH3RF1 protein

NCBI chr16:33,746,396...33,912,127
Ensembl chr16:28,735,440...28,901,644

G

SNF2 histone linker PHD RING helicase

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SHPRH protein

NCBI chr 1:7,349,073...7,422,804
Ensembl chr 1:5,528,888...5,602,527

G

suppressor of IKBKE 1

increases expression

Theophylline results in increased expression of SIKE1 mRNA

NCBI chr 2:193,206,490...193,214,321
Ensembl chr 2:190,518,002...190,525,832

G

sirtuin 2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of SIRT2 protein

NCBI chr 1:93,181,472...93,204,499
Ensembl chr 1:84,052,903...84,076,975

G

SKI3 subunit of superkiller complex

decreases expression

Theophylline results in decreased expression of SKIC3 mRNA

NCBI chr 2:7,363,417...7,526,351
Ensembl chr 2:5,631,635...5,751,626

G

solute carrier family 12, member 8

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SLC12A8 protein

NCBI chr11:80,622,000...80,771,674
Ensembl chr11:67,116,877...67,266,834

G

solute carrier family 12, member 9

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of SLC12A9 protein

NCBI chr12:25,005,741...25,022,628
Ensembl chr12:19,369,004...19,385,877

G

solute carrier family 16 member 1

multiple interactions

Theophylline inhibits the reaction [SLC16A1 protein results in increased uptake of Butyrates]

NCBI chr 2:194,805,556...194,832,966
Ensembl chr 2:192,124,289...192,144,611

G

solute carrier family 25 member 24

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SLC25A24 protein

NCBI chr 2:199,449,425...199,487,287
Ensembl chr 2:196,761,274...196,799,231

G

solute carrier family 39, member 9

increases expression

Theophylline results in increased expression of SLC39A9 mRNA

NCBI chr 6:106,022,858...106,061,734
Ensembl chr 6:100,291,573...100,330,408

G

solute carrier family 5 member 5

increases expression

Theophylline results in increased expression of SLC5A5 protein

NCBI chr16:18,580,705...18,590,692
Ensembl chr16:18,546,709...18,556,697

G

solute carrier organic anion transporter family member 1B2

increases expression

Theophylline results in increased expression of SLCO1B2 mRNA

NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:174,551,480...174,619,981

G

sarcolemma associated protein

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SLMAP protein

NCBI chr16:1,673,964...1,791,902
Ensembl chr16:1,667,208...1,785,149

G

SMAD family member 2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SMAD2 protein

NCBI chr18:72,124,792...72,193,345
Ensembl chr18:69,850,377...69,912,323

G

SMAD family member 5

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SMAD5 protein

NCBI chr17:7,867,640...7,896,983
Ensembl chr17:7,864,720...7,891,634

G

small integral membrane protein 7

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of SMIM7 protein

NCBI chr16:17,308,466...17,312,384
Ensembl chr16:17,273,258...17,278,336

G

SMU1, DNA replication regulator and spliceosomal factor

increases expression

Theophylline results in increased expression of SMU1 mRNA

NCBI chr 5:60,652,680...60,671,251
Ensembl chr 5:55,856,246...55,875,300

G

synaptosome associated protein 23

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SNAP23 protein

NCBI chr 3:127,966,184...127,999,929
Ensembl chr 3:107,514,131...107,544,320

G

sorting nexin 13

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SNX13 protein

NCBI chr 6:57,478,139...57,589,624
Ensembl chr 6:51,753,036...51,860,224

G

spermatogenesis associated, serine-rich 2-like

decreases expression

Theophylline results in decreased expression of SPATS2L mRNA

NCBI chr 9:66,814,217...66,988,084
Ensembl chr 9:59,320,276...59,493,967

G

spindlin family member 2B

decreases expression

Theophylline results in decreased expression of SPIN2B mRNA

NCBI chr X:19,923,341...19,925,119
Ensembl chr X:17,180,474...17,192,351

G

sterol regulatory element binding transcription factor 1

decreases expression

Theophylline results in decreased expression of SREBF1 mRNA

NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,007,637...45,029,650

G

serine racemase

decreases expression

Theophylline results in decreased expression of SRR mRNA

NCBI chr10:60,267,936...60,285,094
Ensembl chr10:59,769,571...59,787,011

G

serine and arginine rich splicing factor 3

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SRSF3 protein

NCBI chr20:7,093,529...7,103,517
Ensembl chr20:7,091,910...7,101,078

G

signal sequence receptor subunit 1

decreases expression

Theophylline results in decreased expression of SSR1 mRNA

NCBI chr17:27,039,203...27,067,352
Ensembl chr17:26,833,741...26,861,821

G

signal sequence receptor subunit 3

increases expression

Theophylline results in increased expression of SSR3 mRNA

NCBI chr 2:151,915,101...151,935,162
Ensembl chr 2:149,605,005...149,625,132

G

somatostatin

increases secretion

Theophylline results in increased secretion of SST protein

NCBI chr11:90,461,546...90,462,823
Ensembl chr11:76,956,896...76,958,173

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 3

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ST3GAL3 protein

NCBI chr 5:136,755,780...136,958,081
Ensembl chr 5:131,470,348...131,670,810

G

signal transducing adaptor molecule 2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of STAM2 protein

NCBI chr 3:57,597,557...57,643,915
Ensembl chr 3:37,186,145...37,234,812

G

signal transducer and activator of transcription 3

increases expression

Theophylline results in increased expression of STAT3 mRNA

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057

G

serine/threonine kinase 24

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of STK24 protein

NCBI chr15:104,770,556...104,866,524
Ensembl chr15:98,365,791...98,460,553

G

serine/threonine kinase 35

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of STK35 protein

NCBI chr 3:137,465,884...137,498,554
Ensembl chr 3:117,016,950...117,048,066

G

SPT6 homolog, histone chaperone and transcription elongation factor

decreases expression

Theophylline results in decreased expression of SUPT6H mRNA

NCBI chr10:63,601,990...63,638,851
Ensembl chr10:63,103,921...63,140,780

G

tachykinin, precursor 1

multiple interactions

Theophylline inhibits the reaction [TAC1 protein results in increased secretion of Histamine]

NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:35,679,704...35,687,178

G

TATA-box binding protein associated factor, RNA polymerase I subunit A

increases expression

Theophylline results in increased expression of TAF1A mRNA

NCBI chr13:97,543,772...97,579,742
Ensembl chr13:95,029,225...95,048,087

G

TATA-box binding protein associated factor 7

decreases expression

Theophylline results in decreased expression of TAF7 mRNA

NCBI chr18:29,704,182...29,713,382
Ensembl chr18:29,452,943...29,462,134

G

threonyl-tRNA synthetase 2, mitochondrial

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of TARS2 protein

NCBI chr 2:185,982,042...185,999,155
Ensembl chr 2:183,293,097...183,310,184

G

taste receptor, type 2, member 116

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TAS2R14 protein

NCBI chr 4:167,998,392...167,999,366
Ensembl chr 4:166,266,984...166,267,958

G

tubulin folding cofactor A

increases expression

Theophylline results in increased expression of TBCA mRNA

NCBI chr 2:27,745,985...27,800,624
Ensembl chr 2:26,011,795...26,065,907

G

thromboxane A synthase 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TBXAS1 protein

NCBI chr 4:68,631,841...68,803,959
Ensembl chr 4:67,665,007...67,837,096

G

transcription factor 3

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of TCF3 protein

NCBI chr 7:9,931,251...9,952,994
Ensembl chr 7:9,280,571...9,302,314

G

transcobalamin 2

increases expression

Theophylline results in increased expression of TCN2 mRNA

NCBI chr14:83,036,935...83,052,187
Ensembl chr14:78,813,343...78,828,489

G

transcription elongation factor, mitochondrial

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TEFM protein

NCBI chr10:65,617,547...65,622,042
Ensembl chr10:65,119,659...65,124,486

G

testis associated actin remodelling kinase 1

increases expression

Theophylline results in increased expression of TESK1 mRNA

NCBI chr 5:62,487,763...62,493,492
Ensembl chr 5:57,691,969...57,697,698

G

transforming growth factor, beta 1

multiple interactions

Theophylline inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Theophylline inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Theophylline promotes the reaction [Dexamethasone inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847

G

TGFB-induced factor homeobox 1

increases expression

Theophylline results in increased expression of TGIF1 mRNA

NCBI chr 9:118,194,735...118,204,354
Ensembl chr 9:110,720,921...110,757,802

G

thyroid hormone responsive

decreases expression

Theophylline results in decreased expression of THRSP mRNA

NCBI chr 1:161,134,640...161,138,964
Ensembl chr 1:151,723,086...151,728,075

G

TIMP metallopeptidase inhibitor 1

increases expression

Theophylline results in increased expression of TIMP1 mRNA

NCBI chr X:3,766,509...3,772,578
Ensembl chr X:1,212,972...1,217,664

G

transmembrane channel-like 5

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TMC5 protein

NCBI chr 1:182,349,102...182,433,679
Ensembl chr 1:172,914,457...172,999,474

G

transmembrane p24 trafficking protein 4

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TMED4 protein

NCBI chr14:85,338,980...85,343,577
Ensembl chr14:81,125,053...81,129,631

G

transmembrane protein 106B

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TMEM106B protein

NCBI chr 4:42,294,074...42,313,426
Ensembl chr 4:41,327,994...41,345,619

G

transmembrane protein 19

decreases expression

Theophylline results in decreased expression of TMEM19 mRNA

NCBI chr 7:52,844,985...52,871,708
Ensembl chr 7:50,958,888...50,986,809

G

transmembrane protein 243

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of TMEM243 protein

NCBI chr 4:25,905,740...25,923,588
Ensembl chr 4:24,950,791...24,968,642

G

transmembrane protein 260

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of TMEM260 protein

NCBI chr15:24,213,658...24,287,242
Ensembl chr15:21,734,151...21,806,801

G

transmembrane protein 63a

decreases expression

Theophylline results in decreased expression of TMEM63A mRNA

NCBI chr13:95,194,323...95,227,944
Ensembl chr13:92,663,968...92,696,183

G

transmembrane protein 80

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of TMEM80 protein

NCBI chr 1:205,865,564...205,873,933
Ensembl chr 1:196,436,003...196,444,367
Ensembl chr 1:196,436,003...196,444,367

G

transmembrane protein 87B

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TMEM87B protein

NCBI chr 3:136,515,155...136,550,644
Ensembl chr 3:116,062,204...116,097,367

G

thioredoxin-related transmembrane protein 3

increases expression

Theophylline results in increased expression of TMX3 mRNA

NCBI chr18:86,021,137...86,054,025
Ensembl chr18:83,731,868...83,762,263

G

tumor necrosis factor

decreases secretion
multiple interactions

Theophylline results in decreased secretion of TNF protein
[Albuterol co-treated with Theophylline] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Albuterol promotes the reaction [Theophylline inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; Theophylline inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein]]]; Theophylline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Theophylline inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Theophylline inhibits the reaction [TNF protein affects the localization of NFKB1 protein]; Theophylline inhibits the reaction [TNF protein results in increased expression of IL6 protein]; Theophylline inhibits the reaction [TNF protein results in increased expression of RELA protein]; Theophylline inhibits the reaction [Tobacco Smoke Pollution inhibits the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein]]]
Theophylline inhibits the reaction [Indomethacin results in increased expression of TNF protein]; Theophylline inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]

PMID:8162974 PMID:10344522 PMID:11694023 PMID:11770011 PMID:16133968 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 8

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TNFAIP8 protein

NCBI chr18:45,370,334...45,486,036
Ensembl chr18:43,183,916...43,299,517

G

tumor protein p53

multiple interactions
decreases expression

[Theophylline co-treated with Chlorambucil] results in increased expression of TP53; IL4 protein inhibits the reaction [[Theophylline co-treated with Chlorambucil] results in increased expression of TP53]
Theophylline results in decreased expression of TP53 mRNA

PMID:8822937 PMID:17522070

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524

G

thiopurine S-methyltransferase

increases expression

Theophylline results in increased expression of TPMT mRNA

NCBI chr17:17,850,308...17,868,976
Ensembl chr17:17,644,173...17,662,709

G

tripeptidyl peptidase 2

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TPP2 protein

NCBI chr 9:53,538,788...53,620,253
Ensembl chr 9:46,046,632...46,128,157

G

TNF receptor-associated factor 1

decreases expression

Theophylline results in decreased expression of TRAF1 mRNA

NCBI chr 3:38,607,707...38,639,641
Ensembl chr 3:18,222,054...18,241,807

G

tRNA methyltransferase 10A

multiple interactions
decreases expression

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TRMT10A protein
Theophylline results in decreased expression of TRMT10A mRNA

NCBI chr 2:229,342,853...229,357,573
Ensembl chr 2:226,669,832...226,684,151

G

tRNA methyltransferase 13 homolog

increases expression

Theophylline results in increased expression of TRMT13 mRNA

NCBI chr 2:207,217,399...207,232,467
Ensembl chr 2:204,533,632...204,546,843

G

tRNA methyltransferase 61A

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of TRMT61A protein

NCBI chr 6:136,558,417...136,564,411
Ensembl chr 6:130,737,219...130,743,243

G

transient receptor potential cation channel, subfamily M, member 7

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TRPM7 protein

NCBI chr 3:134,499,617...134,588,113
Ensembl chr 3:114,046,258...114,135,190

G

tetratricopeptide repeat domain 3

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TTC3 protein

NCBI chr11:47,158,766...47,258,612
Ensembl chr11:33,688,952...33,788,975

G

tubulin tyrosine ligase like 3

affects binding

Theophylline binds to TTLL3 protein

NCBI chr 4:148,088,575...148,113,526
Ensembl chr 4:146,533,953...146,557,889

G

titin

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TTN protein

NCBI chr 3:82,059,648...82,332,130
Ensembl chr 3:61,652,439...61,924,741

G

tubulin, alpha 1B

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of TUBA1B protein

NCBI chr 7:131,969,606...131,972,587
Ensembl chr 7:130,081,032...130,196,186

G

tubulin, delta 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TUBD1 protein

NCBI chr10:71,865,446...71,888,731
Ensembl chr10:71,368,133...71,391,266

G

tumor suppressor candidate 3

increases expression

Theophylline results in increased expression of TUSC3 mRNA

NCBI chr16:59,899,642...60,048,813
Ensembl chr16:53,196,195...53,344,781

G

tyrosinase

increases expression

Theophylline results in increased expression of TYR mRNA; Theophylline results in increased expression of TYR protein

PMID:21071833 PMID:32001318

NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:141,115,036...141,210,207

G

tyrosinase-related protein 1

increases expression

Theophylline results in increased expression of TYRP1 protein

NCBI chr 5:100,327,111...100,345,657
Ensembl chr 5:95,280,982...95,299,516

G

ubiquitin-like modifier activating enzyme 1

affects expression

Theophylline affects the expression of UBA1 mRNA

NCBI chr X:4,062,216...4,084,192
Ensembl chr X:1,508,666...1,530,636

G

ubiquitin-conjugating enzyme E2D 3

affects expression

Theophylline affects the expression of UBE2D3 mRNA

NCBI chr 2:226,543,194...226,571,001
Ensembl chr 2:223,868,730...223,898,081

G

ubiquitin family domain containing 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of UBFD1 protein

NCBI chr 1:176,626,003...176,640,993
Ensembl chr 1:176,625,657...176,640,993

G

ubiquilin 2

increases expression

Theophylline results in increased expression of UBQLN2 mRNA

NCBI chr X:21,228,809...21,232,228
Ensembl chr X:17,853,114...17,856,505

G

ubiquitin protein ligase E3 component n-recognin 3

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of UBR3 protein

NCBI chr 3:75,057,615...75,214,581
Ensembl chr 3:54,649,992...54,806,247

G

upstream binding transcription factor

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of UBTF protein

NCBI chr10:87,758,346...87,775,377
Ensembl chr10:87,258,217...87,272,969

G

ubiquitin C-terminal hydrolase L1

affects expression

Theophylline affects the expression of UCHL1 mRNA

NCBI chr14:41,838,859...41,849,743
Ensembl chr14:41,485,031...41,495,590

G

ubiquitin-fold modifier 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of UFM1 protein

NCBI chr 2:140,119,722...140,127,866
Ensembl chr 2:137,966,678...137,978,089
Ensembl chr 2:137,966,678...137,978,089

G

UTP15, small subunit processome component

increases expression

Theophylline results in increased expression of UTP15 mRNA

NCBI chr 2:31,329,222...31,347,022
Ensembl chr 2:29,594,941...29,612,773

G

UV radiation resistance associated

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of UVRAG protein

NCBI chr 1:162,596,514...162,854,348
Ensembl chr 1:153,185,395...153,442,136

G

vascular endothelial growth factor C

increases expression

Theophylline results in increased expression of VEGFC mRNA

NCBI chr16:44,445,293...44,560,887
Ensembl chr16:37,712,262...37,827,848

G

VPS26 retromer complex component A

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of VPS26A protein

NCBI chr20:30,947,018...30,976,964
Ensembl chr20:30,404,325...30,434,131

G

VPS35 endosomal protein sorting factor like

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of VPS35L protein

NCBI chr 1:182,507,576...182,611,021
Ensembl chr 1:173,076,099...173,180,610

G

visual system homeobox 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of VSX1 protein

NCBI chr 3:159,974,693...159,982,292
Ensembl chr 3:139,514,270...139,521,869

G

WD repeat domain 20

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of WDR20 protein

NCBI chr 6:135,572,502...135,642,688
Ensembl chr 6:129,752,014...129,847,339

G

WT1 associated protein

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of WTAP protein

NCBI chr 1:50,070,973...50,096,074
Ensembl chr 1:47,665,965...47,691,065

G

WW domain-containing oxidoreductase

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of WWOX protein; [Hydrogen Peroxide co-treated with Theophylline] results in increased expression of WWOX protein

NCBI chr19:59,338,402...60,269,323
Ensembl chr19:42,432,152...43,359,391

G

X-linked inhibitor of apoptosis

increases expression

Theophylline results in increased expression of XIAP mRNA

NCBI chr X:125,756,107...125,803,979
Ensembl chr X:120,897,907...120,934,700

G

xylulokinase

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of XYLB protein

NCBI chr 8:127,971,194...128,012,511
Ensembl chr 8:119,096,029...119,128,848

G

Yes1 associated transcriptional regulator

decreases expression

Theophylline results in decreased expression of YAP1 mRNA

NCBI chr 8:13,380,551...13,451,640
Ensembl chr 8:5,095,722...5,167,010

G

Yip1 domain family, member 4

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of YIPF4 protein

NCBI chr 6:26,702,647...26,714,066
Ensembl chr 6:20,950,501...20,962,229

G

Yip1 domain family, member 6

increases expression

Theophylline results in increased expression of YIPF6 mRNA

NCBI chr X:68,079,754...68,091,845
Ensembl chr X:64,040,952...64,054,702

G

YJU2 splicing factor homolog B

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of YJU2B protein

NCBI chr19:40,799,392...40,810,885
Ensembl chr19:23,894,649...23,906,077

G

YTH N6-methyladenosine RNA binding protein C1

increases expression

Theophylline results in increased expression of YTHDC1 mRNA

NCBI chr14:21,540,276...21,570,724
Ensembl chr14:21,185,440...21,216,028

G

zinc finger and BTB domain containing 18

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ZBTB18 protein

NCBI chr13:91,971,602...91,980,058
Ensembl chr13:89,439,420...89,448,862

G

zinc finger and BTB domain containing 25

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ZBTB25 protein

NCBI chr 6:95,070,699...95,095,888
Ensembl chr 6:95,075,331...95,095,755

G

zinc finger and BTB domain containing 45

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ZBTB45 protein

NCBI chr 1:82,707,633...82,712,926
Ensembl chr 1:73,635,448...73,639,556

G

zinc finger CCHC-type containing 10

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ZCCHC10 protein

NCBI chr10:37,971,459...37,981,860

G

zinc finger, DHHC-type containing 11

decreases expression

Theophylline results in decreased expression of ZDHHC11 mRNA

NCBI chr 1:31,124,900...31,156,075
Ensembl chr 1:29,296,334...29,326,898

G

zinc finger AN1-type containing 3

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ZFAND3 protein

NCBI chr20:8,084,898...8,281,093
Ensembl chr20:8,082,200...8,279,616

G

zinc finger protein 24

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ZNF24 protein

NCBI chr18:15,573,031...15,583,432
Ensembl chr18:15,298,290...15,306,799

G

zinc finger protein 354A

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ZNF354A protein

NCBI chr10:35,897,217...35,909,063
Ensembl chr10:35,396,231...35,408,068

G

zinc finger protein 866

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ZNF700 protein

NCBI chr16:19,687,869...19,710,407
Ensembl chr16:19,668,258...19,675,932

G

zinc finger protein-like 1

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ZFPL1 protein

NCBI chr 1:212,803,790...212,807,803
Ensembl chr 1:203,374,504...203,378,487

G

zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2

decreases expression

Theophylline results in decreased expression of ZRSR2 mRNA

NCBI chr X:34,179,279...34,201,989
Ensembl chr X:30,547,536...30,570,125

G

ZXD family zinc finger C

multiple interactions

[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ZXDC protein

NCBI chr 4:124,439,560...124,471,694
Ensembl chr 4:122,882,336...122,916,496

tiquizium bromide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

thiaton results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008

G

myeloperoxidase

multiple interactions

thiaton inhibits the reaction [Indomethacin results in increased activity of MPO protein]

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819

G

nitric oxide synthase 2

multiple interactions

thiaton inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210

tizanidine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 1, subfamily a, polypeptide 2

affects metabolic processing
increases metabolic processing
multiple interactions

CYP1A2 protein affects the metabolism of tizanidine
CYP1A2 protein results in increased metabolism of tizanidine
[[Ethinyl Estradiol co-treated with Gestodene] results in decreased activity of CYP1A2 protein] which results in decreased metabolism of tizanidine; Ciprofloxacin inhibits the reaction [CYP1A2 protein affects the metabolism of tizanidine]; rofecoxib inhibits the reaction [CYP1A2 protein results in increased metabolism of tizanidine]

PMID:15592331 PMID:15834531 PMID:16198659 PMID:16934051 PMID:17618427

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312

tolterodine tartrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

decreases activity

Tolterodine Tartrate results in decreased activity of ABCB4 protein

NCBI chr 4:26,106,895...26,164,440
Ensembl chr 4:25,151,953...25,209,202

G

acyl-CoA synthetase long-chain family member 4

multiple interactions

Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in increased expression of ACSL4 protein]

NCBI chr X:110,739,633...110,803,416
Ensembl chr X:105,942,799...106,006,427

G

aryl hydrocarbon receptor

decreases expression

Tolterodine Tartrate results in decreased expression of AHR mRNA

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568

G

cholinergic receptor, muscarinic 2

multiple interactions

Tolterodine Tartrate binds to and results in decreased activity of CHRM2 protein

NCBI chr 4:65,981,136...66,116,128
Ensembl chr 4:65,014,144...65,149,103

G

cholinergic receptor, muscarinic 3

multiple interactions

Tolterodine Tartrate binds to and results in decreased activity of CHRM3 protein

NCBI chr17:64,696,549...65,158,622
Ensembl chr17:60,005,202...60,467,278

G

cytochrome P450, family 2, subfamily d, polypeptide 4

increases metabolic processing
affects metabolic processing
multiple interactions

CYP2D6 protein results in increased metabolism of Tolterodine Tartrate
CYP2D6 polymorphism affects the metabolism of Tolterodine Tartrate
Fluoxetine inhibits the reaction [CYP2D6 protein results in increased metabolism of Tolterodine Tartrate]

PMID:10583026 PMID:28087463

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759

G

ferritin heavy chain 1

multiple interactions

Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in decreased expression of FTH1 protein]

NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:206,627,103...206,725,424

G

glutathione peroxidase 4

multiple interactions

Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in increased expression of GPX4 protein]

NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:9,650,185...9,652,982

G

interleukin 1 beta

decreases expression
multiple interactions

Tolterodine Tartrate results in decreased expression of IL1B mRNA
Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]

PMID:32816093 PMID:37702107

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

NFE2 like bZIP transcription factor 2

multiple interactions

Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 protein]

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737

G

nuclear receptor subfamily 3, group C, member 1

multiple interactions
decreases expression

Tolterodine Tartrate inhibits the reaction [Dexamethasone results in increased expression of NR3C1 mRNA]
Tolterodine Tartrate results in decreased expression of NR3C1 mRNA

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375

G

prostaglandin-endoperoxide synthase 2

multiple interactions

Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484

G

solute carrier family 22 member 2

multiple interactions

Tolterodine Tartrate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268

G

secretory leukocyte peptidase inhibitor

increases expression

Tolterodine Tartrate results in increased expression of SLPI mRNA

NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:153,082,369...153,084,453

G

transferrin receptor

multiple interactions

Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in increased expression of TFRC protein]

NCBI chr11:81,668,478...81,690,318
Ensembl chr11:68,163,413...68,185,257

G

tumor necrosis factor

multiple interactions

Tolterodine Tartrate inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

trospium chloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions
increases transport

valspodar inhibits the reaction [ABCB1 protein results in increased transport of trospium chloride]

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709

G

solute carrier family 22 member 1

decreases activity
increases metabolic processing

trospium chloride results in decreased activity of SLC22A1 protein
SLC22A1 protein results in increased metabolism of trospium chloride

NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:48,076,666...48,103,678

G

solute carrier family 22 member 2

decreases activity

trospium chloride results in decreased activity of SLC22A2 protein

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier organic anion transporter family, member 1a4

increases metabolic processing
decreases activity

SLCO1A2 protein results in increased metabolism of trospium chloride
trospium chloride results in decreased activity of SLCO1A2 protein; trospium chloride results in decreased activity of SLCO1A2 protein alternative form

NCBI chr 4:176,441,104...176,495,846
Ensembl chr 4:174,710,004...175,254,573

G

solute carrier organic anion transporter family member 1B2

decreases activity

trospium chloride results in decreased activity of SLCO1B3 protein

NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:174,551,480...174,619,981

tubocurarine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

multiple interactions

Tubocurarine promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; Tubocurarine promotes the reaction [haloxon results in increased phosphorylation of ACHE protein]; Tubocurarine promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein]

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651

G

amyloid beta precursor protein

multiple interactions

Tubocurarine inhibits the reaction [[Nicotine results in increased metabolism of APP protein] which results in increased secretion of APP protein modified form]; Tubocurarine inhibits the reaction [Nicotine results in increased metabolism of APP protein]

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561

G

BCL2, apoptosis regulator

multiple interactions

Tubocurarine inhibits the reaction [PTMA protein results in decreased expression of BCL2]

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

bone gamma-carboxyglutamate protein

multiple interactions

Tubocurarine inhibits the reaction [Nicotine results in increased expression of BGLAP]

NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:173,838,518...173,839,495

G

complement C7

multiple interactions
decreases expression

Tubocurarine inhibits the reaction [Nicotine results in increased expression of C7 mRNA]
Tubocurarine results in decreased expression of C7 mRNA

NCBI chr 2:55,815,687...55,892,605
Ensembl chr 2:54,088,116...54,158,535

G

cyclin-dependent kinase 4

multiple interactions

Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CDK4 protein]

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403

G

cholinergic receptor nicotinic alpha 1 subunit

multiple interactions

Tubocurarine inhibits the reaction [CHRNA1 protein binds to PLAU protein]

NCBI chr 3:78,862,286...78,877,353
Ensembl chr 3:58,454,744...58,469,840

G

cholinergic receptor nicotinic alpha 2 subunit

multiple interactions

Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]]

NCBI chr15:44,517,862...44,534,144
Ensembl chr15:40,342,317...40,358,601

G

cholinergic receptor nicotinic alpha 3 subunit

multiple interactions

Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Tubocurarine inhibits the reaction [desnitroimidacloprid results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]
Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]]; Tubocurarine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]

PMID:7808438 PMID:9687574 PMID:16931985 PMID:34628512

NCBI chr 8:64,297,755...64,311,251
Ensembl chr 8:55,401,702...55,415,165

G

cholinergic receptor nicotinic alpha 4 subunit

multiple interactions

Tubocurarine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]]; Tubocurarine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
Tubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]

PMID:7756618 PMID:11711029 PMID:14645658 PMID:16931985

NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:168,136,266...168,156,957

G

cholinergic receptor nicotinic alpha 7 subunit

multiple interactions

Tubocurarine binds to and results in decreased activity of CHRNA7 protein; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Tubocurarine inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]

PMID:10082212 PMID:10216184 PMID:16931985

NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

Tubocurarine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]]; Tubocurarine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]]
Tubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein]

PMID:7756618 PMID:7808438 PMID:11711029 PMID:14645658 PMID:16931985

NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:175,181,402...175,189,619

G

cholinergic receptor nicotinic beta 4 subunit

multiple interactions

Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Tubocurarine inhibits the reaction [desnitroimidacloprid results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]
Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]]; Tubocurarine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]

PMID:7808438 PMID:9687574 PMID:16931985 PMID:34628512

NCBI chr 8:64,312,644...64,333,319
Ensembl chr 8:55,418,313...55,437,027

G

contactin 1

increases expression
decreases expression
multiple interactions

Tubocurarine results in increased expression of CNTN1 mRNA
Tubocurarine results in decreased expression of CNTN1 mRNA
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA]

PMID:12588870 PMID:16949557

NCBI chr 7:125,142,638...125,440,397
Ensembl chr 7:123,372,792...123,558,541

G

colony stimulating factor 2

multiple interactions

Tubocurarine inhibits the reaction [Nicotine results in increased secretion of CSF2 protein]

NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,386,945...38,389,199

G

dihydrofolate reductase

multiple interactions
decreases expression

Tubocurarine inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA]
Tubocurarine results in decreased expression of DHFR mRNA

NCBI chr 2:25,320,895...25,346,004
Ensembl chr 2:23,586,031...23,613,713

G

EMAP like 4

multiple interactions

Tubocurarine inhibits the reaction [Nicotine results in decreased expression of EML4 mRNA]

NCBI chr 6:16,972,054...17,087,365
Ensembl chr 6:11,219,566...11,334,879

G

Fas cell surface death receptor

multiple interactions

Tubocurarine inhibits the reaction [PTMA protein results in increased expression of FAS]

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591

G

fasciculation and elongation protein zeta 1

multiple interactions
decreases expression

Tubocurarine promotes the reaction [Nicotine results in decreased expression of FEZ1 mRNA]
Tubocurarine results in decreased expression of FEZ1 mRNA

NCBI chr 8:44,733,288...44,778,519
Ensembl chr 8:36,544,535...36,589,683

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Tubocurarine inhibits the reaction [Nicotine results in increased expression of FOS]

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036

G

golgin A4

decreases expression
multiple interactions

Tubocurarine results in decreased expression of GOLGA4 mRNA
Tubocurarine inhibits the reaction [Nicotine results in increased expression of GOLGA4 mRNA]

NCBI chr 8:127,085,830...127,163,227

G

interleukin 1 beta

multiple interactions

Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 mRNA]]; Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased secretion of CXCL8 protein]]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

potassium calcium-activated channel subfamily N member 1

decreases activity

Tubocurarine results in decreased activity of KCNN1 protein

NCBI chr16:18,608,782...18,632,571
Ensembl chr16:18,585,992...18,597,482

G

potassium calcium-activated channel subfamily N member 2

decreases activity

Tubocurarine results in decreased activity of KCNN2 protein

PMID:10696100 PMID:10991935

NCBI chr18:40,004,693...40,445,043
Ensembl chr18:37,817,957...38,258,347

G

lysine methyltransferase 2C

multiple interactions
decreases expression

Tubocurarine inhibits the reaction [Nicotine results in decreased expression of KMT2C mRNA]
Tubocurarine results in decreased expression of KMT2C mRNA

NCBI chr 4:10,353,698...10,755,965
Ensembl chr 4:9,609,627...9,833,539

G

lipopolysaccharide-induced TNF factor

multiple interactions

Tubocurarine inhibits the reaction [Nicotine results in decreased expression of LITAF mRNA]

NCBI chr10:5,163,258...5,199,930
Ensembl chr10:4,625,552...4,692,763

G

mitogen activated protein kinase 1

multiple interactions

Tubocurarine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

Tubocurarine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

matrix metallopeptidase 1

multiple interactions

Tubocurarine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP1 protein]]; Tubocurarine inhibits the reaction [Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 protein]]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of MMP1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of MMP1 protein]

PMID:17151781 PMID:18986645

NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:4,658,588...4,679,097

G

ninein

multiple interactions
decreases expression

Tubocurarine inhibits the reaction [Nicotine results in increased expression of NIN mRNA]
Tubocurarine results in decreased expression of NIN mRNA

NCBI chr 6:94,261,382...94,363,679
Ensembl chr 6:88,525,742...88,627,639

G

plasminogen activator, urokinase

multiple interactions

Tubocurarine inhibits the reaction [CHRNA1 protein binds to PLAU protein]

NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,456,232...3,462,775

G

POU class 5 homeobox 1

decreases expression
multiple interactions

Tubocurarine results in decreased expression of POU5F1 mRNA
Tubocurarine inhibits the reaction [Nicotine results in increased expression of POU5F1 mRNA]

PMID:15612475 PMID:15749260

NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,223,129...3,227,891

G

parkin RBR E3 ubiquitin protein ligase

decreases expression

Tubocurarine results in decreased expression of PRKN mRNA

NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:48,690,556...49,882,555

G

prothymosin alpha

multiple interactions

Tubocurarine inhibits the reaction [PTMA protein results in decreased expression of BCL2]; Tubocurarine inhibits the reaction [PTMA protein results in increased expression of FAS]

NCBI chr 9:94,624,194...94,628,276
Ensembl chr 9:87,176,230...87,180,333

G

protein tyrosine phosphatase, receptor type, A

multiple interactions

Tubocurarine inhibits the reaction [Nicotine results in decreased expression of PTPRA mRNA]

NCBI chr 3:138,103,261...138,212,835
Ensembl chr 3:117,650,183...117,759,728

G

RB binding protein 6, ubiquitin ligase

multiple interactions

Tubocurarine inhibits the reaction [Nicotine results in decreased expression of RBBP6 mRNA]

NCBI chr 1:186,934,563...186,966,852
Ensembl chr 1:177,503,313...177,535,678

G

surfactant protein A1

multiple interactions

Tubocurarine inhibits the reaction [Nicotine results in increased expression of SFTPA1 mRNA]

NCBI chr16:17,042,264...17,045,770
Ensembl chr16:17,008,180...17,011,685

G

surfactant protein C

multiple interactions

Tubocurarine inhibits the reaction [Nicotine results in increased expression of SFTPC mRNA]

NCBI chr15:52,006,274...52,009,324
Ensembl chr15:45,596,574...45,610,777

G

SOS Ras/Rac guanine nucleotide exchange factor 1

multiple interactions
decreases expression

Tubocurarine inhibits the reaction [Nicotine results in increased expression of SOS1 mRNA]
Tubocurarine results in decreased expression of SOS1 mRNA

NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:14,533,360...14,611,107

G

secreted phosphoprotein 1

multiple interactions

Tubocurarine inhibits the reaction [Nicotine results in increased expression of SPP1 protein]

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162

G

stress-induced phosphoprotein 1

multiple interactions
decreases expression

Tubocurarine inhibits the reaction [Nicotine results in decreased expression of STIP1 mRNA]
Tubocurarine results in decreased expression of STIP1 mRNA

NCBI chr 1:213,638,641...213,657,654
Ensembl chr 1:204,178,932...204,228,476

G

ubiquitin-conjugating enzyme E2C

multiple interactions
decreases expression

Tubocurarine inhibits the reaction [Nicotine results in decreased expression of UBE2C mRNA]
Tubocurarine results in decreased expression of UBE2C mRNA

NCBI chr 3:173,925,975...173,928,375
Ensembl chr 3:153,506,636...153,513,339

G

ubiquitin protein ligase E3A

increases expression
multiple interactions

Tubocurarine results in increased expression of UBE3A mRNA
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of UBE3A mRNA]

NCBI chr 1:119,204,244...119,297,097
Ensembl chr 1:110,070,480...110,157,250

G

xanthine dehydrogenase

multiple interactions

Tubocurarine inhibits the reaction [Isoflurophate results in increased expression of XDH protein alternative form]

NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:21,530,113...21,592,268

G

zinc finger protein 42

multiple interactions

Tubocurarine inhibits the reaction [Nicotine results in increased expression of ZFP42 mRNA]

NCBI chr16:55,568,903...55,577,883
Ensembl chr16:48,836,648...48,845,401
Ensembl chr 4:48,836,648...48,845,401

G

zinc finger RNA binding protein

decreases expression
multiple interactions

Tubocurarine results in decreased expression of ZFR mRNA
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of ZFR mRNA]

NCBI chr 2:62,864,333...62,927,377
Ensembl chr 2:61,137,611...61,200,322

vecuronium bromide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 protein]

NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily G member 1

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCG1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCG1 protein]

NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,126,687...9,182,948

G

cholinergic receptor, muscarinic 1

multiple interactions

Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]

NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:205,567,220...205,582,356

G

cholinergic receptor, muscarinic 2

multiple interactions

Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]

NCBI chr 4:65,981,136...66,116,128
Ensembl chr 4:65,014,144...65,149,103

G

cholinergic receptor, muscarinic 3

multiple interactions

Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]

NCBI chr17:64,696,549...65,158,622
Ensembl chr17:60,005,202...60,467,278

G

cholinergic receptor, muscarinic 4

multiple interactions

Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein]

NCBI chr 3:98,349,080...98,356,821
Ensembl chr 3:77,893,425...77,901,159

G

cholinergic receptor, muscarinic 5

multiple interactions

Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]

NCBI chr 3:119,739,229...119,791,630
Ensembl chr 3:99,284,846...99,337,252

G

cholinergic receptor nicotinic alpha 3 subunit

multiple interactions

Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]

NCBI chr 8:64,297,755...64,311,251
Ensembl chr 8:55,401,702...55,415,165

G

cholinergic receptor nicotinic alpha 4 subunit

multiple interactions

Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]

PMID:14645658 PMID:16931985

NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:168,136,266...168,156,957

G

cholinergic receptor nicotinic alpha 7 subunit

multiple interactions

Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]

NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]

PMID:14645658 PMID:16931985

NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:175,181,402...175,189,619

G

cholinergic receptor nicotinic beta 4 subunit

multiple interactions

Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]

NCBI chr 8:64,312,644...64,333,319
Ensembl chr 8:55,418,313...55,437,027

G

cytochrome P450, family 11, subfamily a, polypeptide 1

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 protein]

NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP19A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP19A1 protein]

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:54,553,165...54,580,758

G

early growth response 1

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 protein]

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766

G

ETS transcription factor ELK1

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of ELK1 protein]

NCBI chr X:3,692,367...3,709,252
Ensembl chr X:1,139,756...1,155,713

G

histone deacetylase 4

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 protein]

NCBI chr 9:99,950,972...100,200,994
Ensembl chr 9:92,507,611...92,750,164

G

hexosaminidase subunit beta

increases secretion

Vecuronium Bromide results in increased secretion of HEXB protein

NCBI chr 2:30,218,608...30,238,771
Ensembl chr 2:28,484,012...28,504,223

G

hydroxysteroid 11-beta dehydrogenase 2

increases expression
multiple interactions

Vecuronium Bromide results in increased expression of HSD11B2 mRNA; Vecuronium Bromide results in increased expression of HSD11B2 protein
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 protein]

NCBI chr19:50,307,569...50,312,812
Ensembl chr19:33,397,656...33,402,899

G

mitogen activated protein kinase 1

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

nuclear receptor subfamily 1, group H, member 2

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H2 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H2 protein]

NCBI chr 1:104,178,483...104,183,863
Ensembl chr 1:95,041,967...95,047,377

G

nuclear receptor subfamily 1, group H, member 3

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H3 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H3 protein]

NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:77,158,808...77,168,722

G

scavenger receptor class B, member 1

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of SCARB1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of SCARB1 protein]

NCBI chr12:36,957,302...37,023,982
Ensembl chr12:31,296,156...31,362,647

G

steroidogenic acute regulatory protein

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of STAR mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of STAR protein]

NCBI chr16:72,969,824...72,974,447
Ensembl chr16:66,264,807...66,271,672

xylazine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor alpha 2A

multiple interactions

[BRL 44408 binds to and results in decreased activity of ADRA2A protein] inhibits the reaction [Xylazine inhibits the reaction [Potassium results in increased secretion of Norepinephrine]]

NCBI chr 1:263,066,780...263,069,580
Ensembl chr 1:253,060,218...253,064,365

G

hepatitis A virus cellular receptor 1

multiple interactions

[Ketamine co-treated with Xylazine] results in increased secretion of HAVCR1 protein

NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,119,088...31,151,698

G

lipocalin 2

multiple interactions

[Ketamine co-treated with Xylazine] results in decreased secretion of LCN2 protein

NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:15,680,687...15,684,095

G

protein kinase AMP-activated catalytic subunit alpha 1

multiple interactions

[Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA1 mRNA

NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:54,240,137...54,275,978

G

protein kinase AMP-activated catalytic subunit alpha 2

multiple interactions

[Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA2 mRNA

NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:119,813,226...119,879,543

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19909
role	19880
application	19720
pharmaceutical	19558
drug	19558
neuromuscular agent	1327
muscle relaxant	1323
(R)-methocarbamol +	0
(S)-glaucine +	1
(S)-methocarbamol +	0
6-methoxy-2-benzoxazolinone	0
8-bromo-3',5'-cyclic GMP	34
alcuronium +	3
alprazolam	14
antispasmodic drug +	178
atracurium +	6
atracurium besylate +	0
azumolene	0
baclofen	20
beta-erythroidine +	17
carisoprodol +	4
chlormezanone +	0
chlorphenesin +	1
chlorphenesin carbamate	1
chlorzoxazone	16
cisatracurium +	11
cisatracurium besylate	0
cyclobenzaprine +	1
cyclobenzaprine hydrochloride	0
dantrolene	53
dantrolene sodium hemiheptahydrate	0
decamethonium	3
doxacurium +	0
doxacurium chloride	0
dyphylline +	0
eperisone	0
forskoditerpenoside C	0
forskoditerpenoside D	0
forskoditerpenoside E	0
gallamine	0
lanperisone	0
lanperisone hydrochloride	0
methocarbamol	0
midazolam +	43
midazolam hydrochloride	0
nitroglycerin	140
orphenadrine +	419
orphenadrine citrate	0
orphenadrine hydrochloride	0
oxybutynin +	21
pancuronium +	11
pancuronium bromide	0
pridinol	2
quinine +	25
quinine(1+) +	1
rocuronium +	10
rocuronium bromide	0
sodium 8-bromo-3',5'-cyclic GMP	0
succinylcholine +	4
succinylcholine chloride (anhydrous) +	0
succinylcholine chloride dihydrate	0
theophylline +	530
tizanidine	1
tolterodine +	18
tubocurarine	46
vecuronium +	25
vecuronium bromide	25
xylazine	5
xylazine hydrochloride	0

paths to the root