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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:fluticasone
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Accession:CHEBI:5134 term browser browse the term
Definition:A trifluorinated corticosteroid used in the form of its propionate ester for treatment of allergic rhinitis.
Synonyms:exact_synonym: S-(fluoromethyl) (6alpha,11beta,16alpha,17alpha)-6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carbothioate
 related_synonym: Formula=C22H27F3O4S;   InChI=1S/C22H27F3O4S/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-19(15,2)21(14,25)17(27)9-20(13,3)22(11,29)18(28)30-10-23/h4-5,7,11,13-14,16-17,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1;   InChIKey=MGNNYOODZCAHBA-GQKYHHCASA-N;   SMILES=[H][C@@]12C[C@@H](C)[C@](O)(C(=O)SCF)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12C;   fluticasona;   fluticasonum
 xref: CAS:90566-53-3;   KEGG:C07815;   KEGG:D07981
 xref_mesh: MESH:C065382
 xref: PMID:22370858;   PMID:23276699;   PMID:23591272;   PMID:23796052;   Reaxys:8173308;   Wikipedia:Fluticasone


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fluticasone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases secretion
increases expression
multiple interactions		 EXP ABCB1 protein results in increased secretion of Fluticasone
Fluticasone results in increased expression of ABCB1 protein
Elacridar inhibits the reaction [ABCB1 protein results in increased secretion of Fluticasone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Fluticasone]		 CTD PMID:22464980 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ANXA1 annexin A1 affects localization EXP Fluticasone affects the localization of ANXA1 protein CTD PMID:15753895 NCBI chr 9:73,151,865...73,170,393
Ensembl chr 9:73,151,865...73,170,393 		JBrowse link
G AR androgen receptor multiple interactions EXP Fluticasone binds to and results in increased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619 		JBrowse link
G BGLAP bone gamma-carboxyglutamate protein increases expression EXP Fluticasone results in increased expression of BGLAP protein CTD PMID:11555383 NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317 		JBrowse link
G CASP3 caspase 3 multiple interactions EXP [Fluticasone co-treated with Salmeterol Xinafoate] results in increased activity of CASP3 protein CTD PMID:15536434 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP8 caspase 8 multiple interactions EXP [Fluticasone co-treated with Salmeterol Xinafoate] results in increased activity of CASP8 protein CTD PMID:15536434 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CCL11 C-C motif chemokine ligand 11 multiple interactions EXP Fluticasone inhibits the reaction [RELA protein binds to CCL11 promoter]; Fluticasone inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased expression of CCL11 protein]; Fluticasone promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]]; Fluticasone promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL11 protein]] CTD PMID:15531761 NCBI chr17:34,285,742...34,288,334
Ensembl chr17:34,285,742...34,288,334 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions EXP Fluticasone inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; Fluticasone promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL2 protein]] CTD PMID:15531761 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 multiple interactions EXP Fluticasone inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; Fluticasone inhibits the reaction [TNF protein results in increased secretion of CCL5 mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased secretion of CCL5 protein] CTD PMID:9150321 PMID:10903220 PMID:14643170 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793 		JBrowse link
G CSF2 colony stimulating factor 2 multiple interactions
decreases secretion
increases activity		 EXP Fluticasone inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]
Fluticasone results in decreased secretion of CSF2 protein
Fluticasone results in increased activity of CSF2 protein		 CTD PMID:10460758 PMID:10868704 PMID:11730731 NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170 		JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 multiple interactions EXP Fluticasone inhibits the reaction [Particulate Matter results in increased expression of CXCL1 mRNA]; Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]] CTD PMID:31822346 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP Fluticasone inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Fluticasone inhibits the reaction [TNF protein results in increased secretion of CXCL8 mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein] CTD PMID:14643170 PMID:15531761 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 decreases activity EXP Fluticasone results in decreased activity of CYP3A4 protein CTD PMID:20707410 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 affects response to substance
multiple interactions
increases expression
decreases activity
increases metabolic processing		 EXP CYP3A5 protein affects the susceptibility to Fluticasone
Ketoconazole inhibits the reaction [Fluticasone results in increased expression of CYP3A5 mRNA]
Fluticasone results in decreased activity of CYP3A5 protein
CYP3A5 protein results in increased metabolism of Fluticasone		 CTD PMID:20707410 PMID:24555085 NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,996 		JBrowse link
G DUSP1 dual specificity phosphatase 1 multiple interactions
increases expression		 EXP [Fluticasone co-treated with Salmeterol Xinafoate] results in increased expression of DUSP1 mRNA; [Fluticasone co-treated with Tetradecanoylphorbol Acetate] results in increased expression of DUSP1 mRNA; Salmeterol Xinafoate promotes the reaction [Fluticasone results in increased expression of DUSP1 mRNA] CTD PMID:15860753 PMID:15862954 NCBI chr 5:172,768,096...172,771,195
Ensembl chr 5:172,768,096...172,771,195 		JBrowse link
G EPX eosinophil peroxidase multiple interactions ISO Fluticasone inhibits the reaction [sephadex results in increased expression of EPX protein] CTD PMID:10850854 NCBI chr17:58,192,726...58,205,174
Ensembl chr17:58,192,726...58,205,174 		JBrowse link
G GGT5 gamma-glutamyltransferase 5 multiple interactions
increases activity
increases expression		 EXP [Fluticasone results in increased activity of GGT5 protein] which results in increased metabolism of Leukotriene C4
Fluticasone results in increased expression of GGT5 mRNA		 CTD PMID:11447392 NCBI chr22:24,219,654...24,245,142
Ensembl chr22:24,219,654...24,245,108 		JBrowse link
G H4C16 H4 histone 16 multiple interactions EXP Fluticasone inhibits the reaction [TNF protein results in increased acetylation of H4C16 protein] CTD PMID:15531761 NCBI chr12:14,770,720...14,771,131
Ensembl chr12:14,767,999...14,771,131 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions EXP Fluticasone inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:9150321 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G IFNG interferon gamma multiple interactions EXP Fluticasone inhibits the reaction [Amb a I protein, Ambrosia artemisiifolia results in increased expression of IFNG mRNA] CTD PMID:10075860 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP Fluticasone inhibits the reaction [IL1B protein results in increased expression of SELE mRNA]; Fluticasone inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]; Fluticasone inhibits the reaction [Particulate Matter results in increased expression of IL1B mRNA]; Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of IL1B protein]; Mifepristone inhibits the reaction [Fluticasone inhibits the reaction [IL1B protein results in increased expression of SELE mRNA]]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of IL1B protein]] CTD PMID:9371735 PMID:10460758 PMID:31822346 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL2 interleukin 2 multiple interactions EXP Fluticasone inhibits the reaction [Amb a I protein, Ambrosia artemisiifolia results in increased expression of IL2 mRNA] CTD PMID:10075860 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725 		JBrowse link
G IL4 interleukin 4 multiple interactions EXP Fluticasone inhibits the reaction [Amb a I protein, Ambrosia artemisiifolia results in increased expression of IL4 mRNA] CTD PMID:10075860 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678 		JBrowse link
G IL5 interleukin 5 decreases expression
multiple interactions		 EXP Fluticasone results in decreased expression of IL5 protein
Fluticasone inhibits the reaction [Amb a I protein, Ambrosia artemisiifolia results in increased expression of IL5 mRNA]		 CTD PMID:10075860 PMID:15634547 NCBI chr 5:132,541,445...132,556,815
Ensembl chr 5:132,541,445...132,556,838 		JBrowse link
G IL6 interleukin 6 multiple interactions EXP Fluticasone inhibits the reaction [Amb a I protein, Ambrosia artemisiifolia results in increased expression of IL6 mRNA]; Fluticasone inhibits the reaction [Particulate Matter results in increased expression of IL6 mRNA]; Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]] CTD PMID:10075860 PMID:31822346 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G INS-IGF2 INS-IGF2 readthrough multiple interactions ISO Fluticasone inhibits the reaction [Colforsin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Fluticasone inhibits the reaction [Glucose results in increased secretion of INS1 protein] CTD PMID:25851902 NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions EXP Fluticasone inhibits the reaction [Particulate Matter results in increased expression of NFKB1 protein]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased expression of NFKB1 protein]] CTD PMID:31822346 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions EXP [Fluticasone co-treated with Salmeterol Xinafoate] results in decreased phosphorylation of NFKBIA protein CTD PMID:15536434 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Fluticasone results in increased activity of NR1I2 protein CTD PMID:21068194 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487 		JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 multiple interactions
affects binding
affects localization		 EXP
ISO		 [Fluticasone co-treated with Salmeterol Xinafoate] affects the localization of and results in increased activity of NR3C1 protein; [Fluticasone co-treated with Salmeterol Xinafoate] affects the localization of NR3C1 protein; [Fluticasone co-treated with Tetradecanoylphorbol Acetate] affects the localization of NR3C1 protein; Fluticasone affects the localization of and results in increased activity of NR3C1 protein; Fluticasone promotes the reaction [15-deoxyprostaglandin J2 promotes the reaction [NR3C1 protein binds to PPARG protein]]; Salmeterol Xinafoate promotes the reaction [[Fluticasone co-treated with Tetradecanoylphorbol Acetate] affects the localization of NR3C1 protein]; Salmeterol Xinafoate promotes the reaction [Fluticasone affects the localization of and results in increased activity of NR3C1 protein]; Salmeterol Xinafoate promotes the reaction [Fluticasone affects the localization of NR3C1 protein]
Fluticasone binds to NR3C1 protein		 CTD PMID:7878687 PMID:15531761 PMID:15536434 PMID:15860753 PMID:15862954 More... NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512 		JBrowse link
G PGR progesterone receptor multiple interactions EXP Fluticasone binds to and results in increased activity of PGR protein CTD PMID:25752796 NCBI chr11:101,029,624...101,129,813
Ensembl chr11:101,029,624...101,129,813 		JBrowse link
G PLA2G4A phospholipase A2 group IVA affects localization EXP Fluticasone affects the localization of PLA2G4A protein CTD PMID:15753895 NCBI chr 1:186,828,949...186,988,981
Ensembl chr 1:186,828,949...186,988,981 		JBrowse link
G PON1 paraoxonase 1 decreases activity EXP Fluticasone results in decreased activity of PON1 protein CTD PMID:31581362 NCBI chr 7:95,297,676...95,324,532
Ensembl chr 7:95,297,676...95,324,532 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions EXP Fluticasone promotes the reaction [15-deoxyprostaglandin J2 promotes the reaction [NR3C1 protein binds to PPARG protein]] CTD PMID:15531761 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PRKCA protein kinase C alpha decreases expression EXP Fluticasone results in decreased expression of PRKCA protein CTD PMID:15634547 NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP Fluticasone inhibits the reaction [Particulate Matter results in increased expression of RELA protein]; Fluticasone inhibits the reaction [RELA protein binds to CCL11 promoter]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased expression of RELA protein]] CTD PMID:15531761 PMID:31822346 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G SELE selectin E multiple interactions EXP Fluticasone inhibits the reaction [IL1B protein results in increased expression of SELE mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased expression of SELE protein]; Mifepristone inhibits the reaction [Fluticasone inhibits the reaction [IL1B protein results in increased expression of SELE mRNA]] CTD PMID:9371735 NCBI chr 1:169,722,640...169,734,079
Ensembl chr 1:169,722,640...169,764,705 		JBrowse link
G SLC22A3 solute carrier family 22 member 3 multiple interactions EXP Fluticasone inhibits the reaction [SLC22A3 protein results in increased uptake of Formoterol Fumarate]; SLC22A3 protein results in increased susceptibility to [Fluticasone results in decreased transport of Formoterol Fumarate] CTD PMID:17920670 PMID:21914487 NCBI chr 6:160,348,378...160,452,577
Ensembl chr 6:160,348,378...160,452,577 		JBrowse link
G SLPI secretory leukocyte peptidase inhibitor multiple interactions
increases expression		 EXP [Fluticasone co-treated with Salmeterol Xinafoate] results in increased expression of SLPI mRNA; Salmeterol Xinafoate promotes the reaction [Fluticasone results in increased expression of SLPI mRNA] CTD PMID:15860753 PMID:15862954 NCBI chr20:45,252,239...45,254,564
Ensembl chr20:45,252,239...45,254,564 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions EXP Fluticasone inhibits the reaction [Particulate Matter results in increased phosphorylation of STAT3 protein]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased phosphorylation of STAT3 protein]] CTD PMID:31822346 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568 		JBrowse link
G TNF tumor necrosis factor multiple interactions EXP Fluticasone inhibits the reaction [Amb a I protein, Ambrosia artemisiifolia results in increased expression of TNF mRNA]; Fluticasone inhibits the reaction [Particulate Matter results in increased expression of TNF mRNA]; Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]; Fluticasone inhibits the reaction [TNF protein results in increased acetylation of H4C16 protein]; Fluticasone inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased expression of CCL11 protein]; Fluticasone inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; Fluticasone inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; Fluticasone inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Fluticasone inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Fluticasone inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased expression of SELE protein]; Fluticasone inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Fluticasone inhibits the reaction [TNF protein results in increased secretion of CCL5 mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased secretion of CCL5 protein]; Fluticasone inhibits the reaction [TNF protein results in increased secretion of CXCL8 mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]; Fluticasone promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]]; Fluticasone promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL11 protein]]; Fluticasone promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased expression of NFKB1 protein]]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased expression of RELA protein]]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased phosphorylation of STAT3 protein]]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of IL1B protein]]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]] CTD PMID:9150321 PMID:9371735 PMID:10075860 PMID:10100995 PMID:10903220 More... NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions
decreases stability		 EXP Fluticasone inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
Fluticasone results in decreased stability of VCAM1 mRNA		 CTD PMID:10100995 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      application 25172
        anti-asthmatic agent 9719
          anti-asthmatic drug 9138
            fluticasone 42
              fluticasone furoate + 0
              fluticasone propionate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      carbon group element atom 25434
                        carbon atom 25403
                          organic molecular entity 25392
                            heteroorganic entity 24766
                              organochalcogen compound 24378
                                organooxygen compound 24054
                                  carbonyl compound 23563
                                    ketone 19347
                                      oxo steroid 11043
                                        3-oxo steroid 10440
                                          3-oxo-Delta(4) steroid 9651
                                            fluticasone 42
                                              fluticasone furoate + 0
                                              fluticasone propionate 0
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