Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fluticasone
go back to main search page
Accession:CHEBI:5134 term browser browse the term
Definition:A trifluorinated corticosteroid used in the form of its propionate ester for treatment of allergic rhinitis.
Synonyms:exact_synonym: S-(fluoromethyl) (6alpha,11beta,16alpha,17alpha)-6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carbothioate
 related_synonym: Formula=C22H27F3O4S;   InChI=1S/C22H27F3O4S/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-19(15,2)21(14,25)17(27)9-20(13,3)22(11,29)18(28)30-10-23/h4-5,7,11,13-14,16-17,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1;   InChIKey=MGNNYOODZCAHBA-GQKYHHCASA-N;   SMILES=[H][C@@]12C[C@@H](C)[C@](O)(C(=O)SCF)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12C;   fluticasona;   fluticasonum
 xref: CAS:90566-53-3;   KEGG:C07815;   KEGG:D07981
 xref_mesh: MESH:C065382
 xref: PMID:22370858;   PMID:23276699;   PMID:23591272;   PMID:23796052;   Reaxys:8173308;   Wikipedia:Fluticasone



show annotations for term's descendants           Sort by:
 
fluticasone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases secretion
multiple interactions
increases expression
ISO ABCB1 protein results in increased secretion of Fluticasone
Elacridar inhibits the reaction [ABCB1 protein results in increased secretion of Fluticasone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Fluticasone]
Fluticasone results in increased expression of ABCB1 protein
CTD PMID:22464980 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Anxa1 annexin A1 affects localization ISO Fluticasone affects the localization of ANXA1 protein CTD PMID:15753895 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Ar androgen receptor multiple interactions ISO Fluticasone binds to and results in increased activity of AR protein CTD PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression ISO Fluticasone results in increased expression of BGLAP protein CTD PMID:11555383 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Fluticasone co-treated with Salmeterol Xinafoate] results in increased activity of CASP3 protein CTD PMID:15536434 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [Fluticasone co-treated with Salmeterol Xinafoate] results in increased activity of CASP8 protein CTD PMID:15536434 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions ISO Fluticasone inhibits the reaction [RELA protein binds to CCL11 promoter]; Fluticasone inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased expression of CCL11 protein]; Fluticasone promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]]; Fluticasone promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL11 protein]] CTD PMID:15531761 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Fluticasone inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; Fluticasone promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL2 protein]] CTD PMID:15531761 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Fluticasone inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; Fluticasone inhibits the reaction [TNF protein results in increased secretion of CCL5 mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased secretion of CCL5 protein] CTD PMID:9150321 PMID:10903220 PMID:14643170 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
increases activity
decreases secretion
ISO Fluticasone inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]
Fluticasone results in increased activity of CSF2 protein
Fluticasone results in decreased secretion of CSF2 protein
CTD PMID:10460758 PMID:10868704 PMID:11730731 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions ISO Fluticasone inhibits the reaction [Particulate Matter results in increased expression of CXCL1 mRNA]; Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]] CTD PMID:31822346 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO Fluticasone inhibits the reaction [Particulate Matter results in increased expression of CXCL1 mRNA]; Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]] CTD PMID:31822346 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO Fluticasone results in decreased activity of CYP3A4 protein CTD PMID:20707410 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects response to substance
increases metabolic processing
decreases activity
increases expression
multiple interactions
ISO CYP3A5 protein affects the susceptibility to Fluticasone
CYP3A5 protein results in increased metabolism of Fluticasone
Fluticasone results in decreased activity of CYP3A5 protein
Fluticasone results in increased expression of CYP3A5 mRNA
Ketoconazole inhibits the reaction [Fluticasone results in increased expression of CYP3A5 mRNA]
CTD PMID:20707410 PMID:24555085 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions
increases expression
ISO [Fluticasone co-treated with Salmeterol Xinafoate] results in increased expression of DUSP1 mRNA; [Fluticasone co-treated with Tetradecanoylphorbol Acetate] results in increased expression of DUSP1 mRNA; Salmeterol Xinafoate promotes the reaction [Fluticasone results in increased expression of DUSP1 mRNA] CTD PMID:15860753 PMID:15862954 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Epx eosinophil peroxidase multiple interactions EXP Fluticasone inhibits the reaction [sephadex results in increased expression of EPX protein] CTD PMID:10850854 NCBI chr10:72,666,865...72,677,952
Ensembl chr10:72,666,865...72,677,952
JBrowse link
G Ggt5 gamma-glutamyltransferase 5 multiple interactions
increases activity
increases expression
ISO [Fluticasone results in increased activity of GGT5 protein] which results in increased metabolism of Leukotriene C4
Fluticasone results in increased expression of GGT5 mRNA
CTD PMID:11447392 NCBI chr20:13,043,255...13,071,523
Ensembl chr20:13,043,257...13,071,450
JBrowse link
G H4f16 H4 histone 16 multiple interactions ISO Fluticasone inhibits the reaction [TNF protein results in increased acetylation of H4-16 protein] CTD PMID:15531761
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Fluticasone inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:9150321 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma multiple interactions ISO Fluticasone inhibits the reaction [Amb a I protein, Ambrosia artemisiifolia results in increased expression of IFNG mRNA] CTD PMID:10075860 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Fluticasone inhibits the reaction [IL1B protein results in increased expression of SELE mRNA]; Fluticasone inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]; Fluticasone inhibits the reaction [Particulate Matter results in increased expression of IL1B mRNA]; Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of IL1B protein]; Mifepristone inhibits the reaction [Fluticasone inhibits the reaction [IL1B protein results in increased expression of SELE mRNA]]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of IL1B protein]] CTD PMID:9371735 PMID:10460758 PMID:31822346 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions ISO Fluticasone inhibits the reaction [Amb a I protein, Ambrosia artemisiifolia results in increased expression of IL2 mRNA] CTD PMID:10075860 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 multiple interactions ISO Fluticasone inhibits the reaction [Amb a I protein, Ambrosia artemisiifolia results in increased expression of IL4 mRNA] CTD PMID:10075860 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 decreases expression
multiple interactions
ISO Fluticasone results in decreased expression of IL5 protein
Fluticasone inhibits the reaction [Amb a I protein, Ambrosia artemisiifolia results in increased expression of IL5 mRNA]
CTD PMID:10075860 PMID:15634547 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Fluticasone inhibits the reaction [Amb a I protein, Ambrosia artemisiifolia results in increased expression of IL6 mRNA]; Fluticasone inhibits the reaction [Particulate Matter results in increased expression of IL6 mRNA]; Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]] CTD PMID:10075860 PMID:31822346 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Fluticasone inhibits the reaction [Particulate Matter results in increased expression of NFKB1 protein]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased expression of NFKB1 protein]] CTD PMID:31822346 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [Fluticasone co-treated with Salmeterol Xinafoate] results in decreased phosphorylation of NFKBIA protein CTD PMID:15536434 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Fluticasone results in increased activity of NR1I2 protein CTD PMID:21068194 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
affects binding
affects localization
ISO
EXP
[Fluticasone co-treated with Salmeterol Xinafoate] affects the localization of and results in increased activity of NR3C1 protein; [Fluticasone co-treated with Salmeterol Xinafoate] affects the localization of NR3C1 protein; [Fluticasone co-treated with Tetradecanoylphorbol Acetate] affects the localization of NR3C1 protein; Fluticasone affects the localization of and results in increased activity of NR3C1 protein; Fluticasone promotes the reaction [15-deoxyprostaglandin J2 promotes the reaction [NR3C1 protein binds to PPARG protein]]; Salmeterol Xinafoate promotes the reaction [[Fluticasone co-treated with Tetradecanoylphorbol Acetate] affects the localization of NR3C1 protein]; Salmeterol Xinafoate promotes the reaction [Fluticasone affects the localization of and results in increased activity of NR3C1 protein]; Salmeterol Xinafoate promotes the reaction [Fluticasone affects the localization of NR3C1 protein]
Fluticasone binds to NR3C1 protein
CTD PMID:7878687 PMID:15531761 PMID:15536434 PMID:15860753 PMID:15862954 More... NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Fluticasone binds to and results in increased activity of PGR protein CTD PMID:25752796 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Pla2g4a phospholipase A2 group IVA affects localization ISO Fluticasone affects the localization of PLA2G4A protein CTD PMID:15753895 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
JBrowse link
G Pon1 paraoxonase 1 decreases activity ISO Fluticasone results in decreased activity of PON1 protein CTD PMID:31581362 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Fluticasone promotes the reaction [15-deoxyprostaglandin J2 promotes the reaction [NR3C1 protein binds to PPARG protein]] CTD PMID:15531761 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Prkca protein kinase C, alpha decreases expression ISO Fluticasone results in decreased expression of PRKCA protein CTD PMID:15634547 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Fluticasone inhibits the reaction [Particulate Matter results in increased expression of RELA protein]; Fluticasone inhibits the reaction [RELA protein binds to CCL11 promoter]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased expression of RELA protein]] CTD PMID:15531761 PMID:31822346 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sele selectin E multiple interactions ISO Fluticasone inhibits the reaction [IL1B protein results in increased expression of SELE mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased expression of SELE protein]; Mifepristone inhibits the reaction [Fluticasone inhibits the reaction [IL1B protein results in increased expression of SELE mRNA]] CTD PMID:9371735 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO Fluticasone inhibits the reaction [SLC22A3 protein results in increased uptake of Formoterol Fumarate]; SLC22A3 protein results in increased susceptibility to [Fluticasone results in decreased transport of Formoterol Fumarate] CTD PMID:17920670 PMID:21914487 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor multiple interactions
increases expression
ISO [Fluticasone co-treated with Salmeterol Xinafoate] results in increased expression of SLPI mRNA; Salmeterol Xinafoate promotes the reaction [Fluticasone results in increased expression of SLPI mRNA] CTD PMID:15860753 PMID:15862954 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Fluticasone inhibits the reaction [Particulate Matter results in increased phosphorylation of STAT3 protein]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased phosphorylation of STAT3 protein]] CTD PMID:31822346 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Fluticasone inhibits the reaction [Amb a I protein, Ambrosia artemisiifolia results in increased expression of TNF mRNA]; Fluticasone inhibits the reaction [Particulate Matter results in increased expression of TNF mRNA]; Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]; Fluticasone inhibits the reaction [TNF protein results in increased acetylation of H4-16 protein]; Fluticasone inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased expression of CCL11 protein]; Fluticasone inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; Fluticasone inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; Fluticasone inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Fluticasone inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Fluticasone inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased expression of SELE protein]; Fluticasone inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Fluticasone inhibits the reaction [TNF protein results in increased secretion of CCL5 mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased secretion of CCL5 protein]; Fluticasone inhibits the reaction [TNF protein results in increased secretion of CXCL8 mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]; Fluticasone promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]]; Fluticasone promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL11 protein]]; Fluticasone promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased expression of NFKB1 protein]]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased expression of RELA protein]]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased phosphorylation of STAT3 protein]]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of IL1B protein]]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]] CTD PMID:9150321 PMID:9371735 PMID:10075860 PMID:10100995 PMID:10903220 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
decreases stability
ISO Fluticasone inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
Fluticasone results in decreased stability of VCAM1 mRNA
CTD PMID:10100995 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20039
    role 19990
      application 19729
        anti-asthmatic agent 9246
          anti-asthmatic drug 8615
            fluticasone 41
              fluticasone furoate + 0
              fluticasone propionate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20039
    subatomic particle 20037
      composite particle 20037
        hadron 20037
          baryon 20037
            nucleon 20037
              atomic nucleus 20037
                atom 20037
                  main group element atom 19938
                    p-block element atom 19938
                      carbon group element atom 19861
                        carbon atom 19852
                          organic molecular entity 19852
                            organic group 18932
                              organic divalent group 18916
                                organodiyl group 18916
                                  carbonyl group 18865
                                    carbonyl compound 18865
                                      ketone 17087
                                        oxo steroid 10297
                                          3-oxo steroid 9897
                                            3-oxo-Delta(4) steroid 9132
                                              fluticasone 41
                                                fluticasone furoate + 0
                                                fluticasone propionate 0
paths to the root