esoxybutynin - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	esoxybutynin	go back to main search page
Accession:	CHEBI:51329	browse the term
Definition:	A 4-(diethylamino)but-2-yn-1-ol yhat has S configuration. In contrast to the (R)- enantiomer, esoxybutynin exhibits essentially no anticholinergic activity.
Synonyms:	exact_synonym:	4-(diethylamino)but-2-yn-1-yl (2S)-cyclohexyl(hydroxy)phenylacetate
	related_synonym:	(+)-oxybutynin; (S)-oxybutynin; Formula=C22H31NO3; InChI=1S/C22H31NO3/c1-3-23(4-2)17-11-12-18-26-21(24)22(25,19-13-7-5-8-14-19)20-15-9-6-10-16-20/h5,7-8,13-14,20,25H,3-4,6,9-10,15-18H2,1-2H3/t22-/m1/s1; InChIKey=XIQVNETUBQGFHX-JOCHJYFZSA-N; SMILES=C1(CCCCC1)[C@](C2=CC=CC=C2)(C(OCC#CCN(CC)CC)=O)O; esoxibutinina; esoxybutynine; esoxybutyninum
	xref:	CAS:119618-22-3; PMID:10987980; PMID:12001823; PMID:12431028; PMID:24036364; PMID:25215879; PMID:26852022
	cyclic_relationship:	is_enantiomer_of CHEBI:144552

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Genes (21)

oxybutynin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases activity

oxybutynin results in decreased activity of ABCB11 protein

PMID:20829430 PMID:28437613

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 4

decreases activity

oxybutynin results in decreased activity of ABCB4 protein

NCBI chr 4:26,106,895...26,164,440
Ensembl chr 4:25,151,953...25,209,202

G

C-C motif chemokine ligand 2

multiple interactions

oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226

G

carboxylesterase 2H

increases hydrolysis

CES2 protein results in increased hydrolysis of oxybutynin

NCBI chr19:49,884,164...49,898,764
Ensembl chr19:32,974,242...32,988,830

G

cholinergic receptor, muscarinic 2

multiple interactions

oxybutynin binds to and results in decreased activity of CHRM2 protein

NCBI chr 4:65,981,136...66,116,128
Ensembl chr 4:65,014,144...65,149,103

G

cholinergic receptor, muscarinic 3

multiple interactions

oxybutynin binds to and results in decreased activity of CHRM3 protein

NCBI chr17:64,696,549...65,158,622
Ensembl chr17:60,005,202...60,467,278

G

cytochrome P450, family 2, subfamily c, polypeptide 79

decreases activity

oxybutynin results in decreased activity of CYP2C8 protein

G

dopamine receptor D2

affects binding

oxybutynin binds to DRD2 protein

NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:49,708,927...49,772,875

G

interleukin 1 beta

multiple interactions

oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 24

decreases expression

oxybutynin results in decreased expression of IL24 mRNA

NCBI chr13:44,905,362...44,910,760
Ensembl chr13:42,353,090...42,358,487

G

interleukin 6

multiple interactions

oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression

oxybutynin results in decreased expression of JUN mRNA

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656

G

MET proto-oncogene, receptor tyrosine kinase

decreases expression

oxybutynin results in decreased expression of MET mRNA

NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:45,790,791...45,897,876

G

matrix metallopeptidase 2

multiple interactions

oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 mRNA]; oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 protein]

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions

oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]; oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120

G

nitric oxide synthase 2

multiple interactions

oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

oxybutynin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484

G

solute carrier family 22 member 2

multiple interactions

oxybutynin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268

G

secretory leukocyte peptidase inhibitor

increases expression

oxybutynin results in increased expression of SLPI mRNA

NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:153,082,369...153,084,453

G

toll-like receptor 4

multiple interactions

oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

multiple interactions

oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19887
role	19858
biological role	19856
pharmacological role	19088
antagonist	17242
calcium channel blocker	7165
esoxybutynin	21
esoxybutynin chloride	0
oxybutynin +	21
Path 2
Term	Annotations
CHEBI ontology	19887
subatomic particle	19885
composite particle	19885
hadron	19885
baryon	19885
nucleon	19885
atomic nucleus	19885
atom	19885
main group element atom	19824
main group molecular entity	19824
s-block molecular entity	19658
hydrogen molecular entity	19640
hydrides	19145
inorganic hydride	18162
pnictogen hydride	18152
nitrogen hydride	18059
azane	17869
ammonia	17868
organic amino compound	17868
tertiary amino compound	10162
4-(diethylamino)but-2-yn-1-ol	21
esoxybutynin	21
esoxybutynin chloride	0
oxybutynin +	21

paths to the root