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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dinitrile
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Accession:CHEBI:51308 term browser browse the term
Definition:A dinitrile is a compound containing two nitrile groups.
Synonyms:related_synonym: dinitriles


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carbonyl cyanide p-trifluoromethoxyphenylhydrazone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions EXP [Egtazic Acid co-treated with Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone] inhibits the reaction [AGT protein results in increased abundance of Reactive Oxygen Species] CTD PMID:18854758 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased phosphorylation of AKT1 protein CTD PMID:19901985 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Aqp9 aquaporin 9 multiple interactions ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone inhibits the reaction [AQP9 protein results in increased uptake of Lactic Acid]; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone inhibits the reaction [AQP9 protein results in increased uptake of Selenious Acid] CTD PMID:28798983 NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of BAX mRNA CTD PMID:16039398 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of BCL2L1 mRNA CTD PMID:16039398 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Casp3 caspase 3 increases activity ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased activity of CASP3 protein CTD PMID:20683024 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of CASP8 mRNA CTD PMID:16039398 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cat catalase decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of CAT mRNA CTD PMID:16039398 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccnc cyclin C decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of CCNC mRNA CTD PMID:16039398 NCBI chr 5:35,266,828...35,284,943
Ensembl chr 5:35,266,823...35,296,584
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of CCND1 mRNA CTD PMID:16039398 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccng1 cyclin G1 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of CCNG1 mRNA CTD PMID:16039398 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone promotes the reaction [CDKN1B protein binds to CDK4 protein] CTD PMID:19819288 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions
increases expression
ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone promotes the reaction [CDKN1B protein binds to CDK4 protein]
Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of CDKN1B protein
CTD PMID:19819288 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Comt catechol-O-methyltransferase decreases activity
multiple interactions
ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased activity of COMT protein
[Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphate
CTD PMID:14975680 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Coq10a coenzyme Q10A decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of COQ10A protein CTD PMID:21308897 NCBI chr 7:792,089...798,392
Ensembl chr 7:792,089...800,161
JBrowse link
G Coq2 coenzyme Q2, polyprenyltransferase increases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of COQ2 mRNA CTD PMID:21308897 NCBI chr14:8,941,429...8,961,418
Ensembl chr14:8,941,461...8,960,891
JBrowse link
G Coq3 coenzyme Q3 methyltransferase decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of COQ3 mRNA CTD PMID:21308897 NCBI chr 5:35,429,567...35,460,613
Ensembl chr 5:35,429,574...35,460,607
JBrowse link
G Coq4 coenzyme Q4 increases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of COQ4 mRNA CTD PMID:21308897 NCBI chr 3:13,060,054...13,070,502
Ensembl chr 3:13,060,455...13,068,799
JBrowse link
G Coq5 coenzyme Q5, methyltransferase increases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of COQ5 mRNA CTD PMID:21308897 NCBI chr12:41,316,922...41,333,855
Ensembl chr12:41,316,748...41,333,848
JBrowse link
G Coq6 coenzyme Q6 monooxygenase increases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of COQ6 mRNA CTD PMID:21308897 NCBI chr 6:104,007,814...104,019,888
Ensembl chr 6:104,007,872...104,024,657
JBrowse link
G Coq7 coenzyme Q7, hydroxylase increases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of COQ7 mRNA CTD PMID:21308897 NCBI chr 1:172,836,359...172,851,173
Ensembl chr 1:172,835,188...172,851,158
JBrowse link
G Coq8a coenzyme Q8A increases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of COQ8A mRNA CTD PMID:21308897 NCBI chr13:91,904,731...91,933,588
Ensembl chr13:91,904,739...91,931,431
JBrowse link
G Coq9 coenzyme Q9 increases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of COQ9 mRNA CTD PMID:21308897 NCBI chr19:10,166,948...10,179,976
Ensembl chr19:10,166,951...10,179,949
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of CYP1A1 mRNA CTD PMID:16039398 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Ddb1 damage-specific DNA binding protein 1 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of DDB1 mRNA CTD PMID:16039398 NCBI chr 1:207,252,890...207,278,685
Ensembl chr 1:207,252,890...207,278,676
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of DNAJA1 mRNA CTD PMID:16039398 NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967
JBrowse link
G Egr1 early growth response 1 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of EGR1 mRNA CTD PMID:16039398 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Ephx2 epoxide hydrolase 2 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of EPHX2 mRNA CTD PMID:16039398 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
JBrowse link
G Fmr1 FMRP translational regulator 1 multiple interactions ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone inhibits the reaction [FMR1 5' UTR mutant form results in increased abundance of Hydroxyl Radical]; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone inhibits the reaction [FMR1 5' UTR mutant form results in increased abundance of Superoxides] CTD PMID:27385396 NCBI chr  X:147,240,239...147,278,057
Ensembl chr  X:147,240,301...147,278,050
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of GADD45A mRNA CTD PMID:16039398 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of GDF15 mRNA CTD PMID:16039398 NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
JBrowse link
G Gsr glutathione-disulfide reductase decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of GSR mRNA CTD PMID:16039398 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gstm3 glutathione S-transferase mu 3 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of GSTM3 mRNA CTD PMID:16039398
G Gstm5 glutathione S-transferase, mu 5 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of GSTM3 mRNA CTD PMID:16039398 NCBI chr 2:195,531,627...195,534,562
Ensembl chr 2:195,531,495...195,534,553
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of HMOX1 mRNA CTD PMID:16039398 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hmox2 heme oxygenase 2 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of HMOX2 mRNA CTD PMID:16039398 NCBI chr10:10,797,076...10,831,178
Ensembl chr10:10,797,055...10,831,148
JBrowse link
G Hsf1 heat shock transcription factor 1 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of HSF1 mRNA CTD PMID:16039398 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of HSP90AA1 mRNA CTD PMID:16039398 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of HSPA1A mRNA CTD PMID:16039398
G Hspa1b heat shock protein family A (Hsp70) member 1B decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of HSPA1B mRNA CTD PMID:16039398 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of HSPA1L mRNA CTD PMID:16039398 NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571
JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of HSPA2 mRNA CTD PMID:16039398 NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of HSPA4 mRNA CTD PMID:16039398 NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of HSPA8 mRNA CTD PMID:16039398 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 increases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of HSPE1 mRNA CTD PMID:16039398 NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression EXP Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of ICAM1 mRNA CTD PMID:17416599 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il18 interleukin 18 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of IL18 mRNA CTD PMID:16039398 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of IL1A mRNA CTD PMID:16039398 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Kcnj12 potassium inwardly-rectifying channel, subfamily J, member 12 multiple interactions ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone inhibits the reaction [KCNJ12 protein results in increased transport of Potassium] CTD PMID:12118013 NCBI chr10:45,696,621...45,745,528
Ensembl chr10:45,696,849...45,745,492
JBrowse link
G Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 multiple interactions ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone inhibits the reaction [KCNJ4 protein results in increased transport of Potassium] CTD PMID:12118013 NCBI chr 7:111,047,097...111,074,151
Ensembl chr 7:111,047,094...111,074,151
JBrowse link
G Mdm2 MDM2 proto-oncogene decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of MDM2 mRNA CTD PMID:16039398 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Mt1 metallothionein 1 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of MT1A mRNA CTD PMID:16039398 NCBI chr19:10,826,032...10,827,048 JBrowse link
G Mt2A metallothionein 2A decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of MT2A mRNA CTD PMID:16039398 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of NFKBIA mRNA CTD PMID:16039398 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nipa1 NIPA magnesium transporter 1 decreases expression EXP Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of NIPA1 mRNA CTD PMID:27157538 NCBI chr 1:106,834,000...106,875,148
Ensembl chr 1:106,834,000...106,874,790
JBrowse link
G Pdss1 decaprenyl diphosphate synthase subunit 1 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of PDSS1 mRNA CTD PMID:21308897 NCBI chr17:85,059,953...85,098,739
Ensembl chr17:85,060,106...85,098,730
JBrowse link
G Pdss2 decaprenyl diphosphate synthase subunit 2 increases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of PDSS2 mRNA CTD PMID:21308897 NCBI chr20:46,709,631...46,938,704
Ensembl chr20:46,709,649...46,938,708
JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions ISO PINK1 protein affects the reaction [Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone affects the localization of PRKN protein] CTD PMID:24879156 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
JBrowse link
G Plcg1 phospholipase C, gamma 1 increases phosphorylation ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased phosphorylation of PLCG1 protein CTD PMID:19901985 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A multiple interactions ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone promotes the reaction [TARDBP protein binds to PPP1R15A protein] CTD PMID:29109149 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases phosphorylation ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased phosphorylation of PRKAA1 protein CTD PMID:19901985 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions
affects localization
ISO PINK1 protein affects the reaction [Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone affects the localization of PRKN protein] CTD PMID:24879156 NCBI chr 1:48,688,651...49,882,520 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of PTGS2 mRNA CTD PMID:16039398 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rad23a RAD23 homolog A, nucleotide excision repair protein decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of RAD23A mRNA CTD PMID:16039398 NCBI chr19:23,313,563...23,320,702
Ensembl chr19:23,314,797...23,320,695
JBrowse link
G Rpl13a ribosomal protein L13A decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of RPL13A mRNA CTD PMID:16039398 NCBI chr 1:95,609,374...95,612,557 JBrowse link
G Serpine1 serpin family E member 1 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of SERPINE1 mRNA CTD PMID:16039398 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions EXP Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin] CTD PMID:1438304 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325
JBrowse link
G Slc41a2 solute carrier family 41 member 2 increases expression EXP Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of SLC41A2 mRNA CTD PMID:27157538 NCBI chr 7:20,383,714...20,491,178
Ensembl chr 7:20,383,757...20,491,166
JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of SOD2 mRNA CTD PMID:16039398 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Stat3 signal transducer and activator of transcription 3 affects response to substance ISO STAT3 protein affects the susceptibility to Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone CTD PMID:20224768 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tardbp TAR DNA binding protein multiple interactions ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone promotes the reaction [TARDBP protein binds to PPP1R15A protein] CTD PMID:29109149 NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055
JBrowse link
G Xrcc5 X-ray repair cross complementing 5 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of XRCC5 mRNA CTD PMID:16039398 NCBI chr 9:73,955,220...74,044,020
Ensembl chr 9:73,955,216...74,044,018
JBrowse link
CCCP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions EXP Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [Glucose results in increased expression of AGT mRNA]; Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [Glucose results in increased expression of AGT protein] CTD PMID:12130563 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Ambra1 autophagy and beclin 1 regulator 1 multiple interactions ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [AMBRA1 protein binds to PRKN protein] CTD PMID:24879156 NCBI chr 3:77,700,936...77,890,221
Ensembl chr 3:77,700,936...77,890,221
JBrowse link
G Atm ATM serine/threonine kinase multiple interactions
increases phosphorylation
ISO ATM protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of COX4 protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [PINK1 protein binds to ATM protein]
Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased phosphorylation of ATM protein
CTD PMID:29660402 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Becn1 beclin 1 multiple interactions ISO
EXP
Carbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [BECN1 protein binds to PRKN protein]
BECN1 protein inhibits the reaction [BECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]]; Carbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [BECN1 protein binds to PRKN protein]
BECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PINK1 protein]; BECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]; BECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of and results in increased ubiquitination of MFN2 protein]; BECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased phosphorylation of PRKN protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [BECN1 protein binds to PRKN protein]
CTD PMID:24879156 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Bnip3l BCL2 interacting protein 3 like increases phosphorylation
multiple interactions
ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased phosphorylation of BNIP3L protein
BNIP3L protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of COX4 protein]; BNIP3L protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of HSPD1 protein]
CTD PMID:32142837 NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803
JBrowse link
G Canx calnexin affects localization ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of CANX protein CTD PMID:28940366 NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821
JBrowse link
G Casp1 caspase 1 multiple interactions ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased cleavage of CASP1 protein] CTD PMID:33524445 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
EXP
ISO
Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [Testosterone results in increased cleavage of CASP3 protein]
DNM1L protein promotes the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of CASP3 protein modified form]; PGAM5 protein promotes the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of CASP3 protein modified form]
CTD PMID:24658017 PMID:29241732 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases expression
multiple interactions
ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of CASP9 protein modified form
DNM1L protein promotes the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of CASP9 protein modified form]
CTD PMID:29241732 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cirbp cold inducible RNA binding protein decreases expression ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of CIRBP mRNA CTD PMID:15075239 NCBI chr 7:9,533,857...9,538,899 JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 decreases expression ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of COX4I1 protein CTD PMID:27318970 NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921
JBrowse link
G Ctsl cathepsin L increases expression ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of CTSL mRNA CTD PMID:15978749 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
JBrowse link
G Dnm1l dynamin 1-like multiple interactions
decreases expression
ISO DNM1L protein promotes the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of CASP3 protein modified form]; DNM1L protein promotes the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of CASP9 protein modified form]
Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of DNM1L protein modified form
CTD PMID:28940366 PMID:29241732 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
JBrowse link
G Faslg Fas ligand multiple interactions EXP Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [Testosterone results in increased expression of FASLG mRNA] CTD PMID:24658017 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 multiple interactions ISO [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of and affects the localization of PINK1 protein] promotes the reaction [FKBP5 protein binds to PINK1 protein] CTD PMID:30734931 NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674
JBrowse link
G Fmc1 formation of mitochondrial complex V assembly factor 1 decreases expression
multiple interactions
ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of FMC1 protein
bafilomycin A1 inhibits the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of FMC1 protein]
CTD PMID:29371327 NCBI chr 4:67,274,104...67,282,140
Ensembl chr 4:67,274,104...67,282,140
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 decreases expression
multiple interactions
ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of HSPD1 protein
BNIP3L protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of HSPD1 protein]
CTD PMID:32142837 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL1B mRNA] CTD PMID:33524445 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO [[Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [SQSTM1 protein binds to KEAP1 protein]] promotes the reaction [KEAP1 protein binds to NFE2L2 protein]] which results in decreased activity of NFE2L2 protein; [Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [SQSTM1 protein binds to KEAP1 protein]] promotes the reaction [KEAP1 protein binds to NFE2L2 protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [SQSTM1 protein binds to KEAP1 protein] CTD PMID:30715550 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Lep leptin multiple interactions
decreases response to substance
ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species]
Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased susceptibility to LEP protein
CTD PMID:11342529 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lonp1 lon peptidase 1, mitochondrial increases expression ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of LONP1 mRNA CTD PMID:28940366 NCBI chr 9:1,447,444...1,459,771
Ensembl chr 9:1,447,447...1,459,771
JBrowse link
G Mapt microtubule-associated protein tau affects localization EXP Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of MAPT protein CTD PMID:17634376 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mfn2 mitofusin 2 multiple interactions EXP
ISO
BECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of and results in increased ubiquitination of MFN2 protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of and results in increased ubiquitination of MFN2 protein
Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of and affects the localization of MFN2 protein
CTD PMID:24879156 PMID:28940366 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO [[Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [SQSTM1 protein binds to KEAP1 protein]] promotes the reaction [KEAP1 protein binds to NFE2L2 protein]] which results in decreased activity of NFE2L2 protein; [Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [SQSTM1 protein binds to KEAP1 protein]] promotes the reaction [KEAP1 protein binds to NFE2L2 protein] CTD PMID:30715550 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of NFKB1 protein CTD PMID:15978749 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbib NFKB inhibitor beta decreases expression ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of NFKBIB protein CTD PMID:15978749 NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NLRP3 protein] CTD PMID:33524445 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase decreases expression ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of OPA1 protein alternative form CTD PMID:28940366 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109
JBrowse link
G Park7 Parkinsonism associated deglycase multiple interactions ISO PARK7 gene mutant form promotes the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein] CTD PMID:22872702 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
JBrowse link
G Pgam5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase multiple interactions ISO PGAM5 protein promotes the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of CASP3 protein modified form] CTD PMID:29241732 NCBI chr12:46,409,324...46,416,410
Ensembl chr12:46,409,369...46,416,420
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 multiple interactions ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [PIK3C3 protein binds to PRKN protein] CTD PMID:24879156 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048
JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions
affects localization
increases expression
increases stability
ISO
EXP
PINK1 gene mutant form inhibits the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]
BECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PINK1 protein]; PINK1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]
[Carbonyl Cyanide m-Chlorophenyl Hydrazone co-treated with PRKN protein] results in increased expression of PINK1 protein; [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of and affects the localization of PINK1 protein] promotes the reaction [FKBP5 protein binds to PINK1 protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [PINK1 protein binds to ATM protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of and affects the localization of PINK1 protein; Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of and results in increased phosphorylation of PINK1 protein
Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of PINK1 protein
Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased stability of PINK1 protein
CTD PMID:22872702 PMID:24879156 PMID:26070385 PMID:27318970 PMID:28673964 More... NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase affects localization
increases response to substance
decreases response to substance
affects expression
decreases expression
increases phosphorylation
multiple interactions
ISO
EXP
Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein
PRKN gene mutant form results in increased susceptibility to Carbonyl Cyanide m-Chlorophenyl Hydrazone
PRKN protein results in decreased susceptibility to Carbonyl Cyanide m-Chlorophenyl Hydrazone
Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the expression of PRKN protein alternative form
Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of PRKN protein
Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased phosphorylation of PRKN protein
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]; Acetylcysteine inhibits the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [BECN1 protein binds to PRKN protein]; PARK7 gene mutant form promotes the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]; PINK1 gene mutant form inhibits the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]
BECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]; BECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased phosphorylation of PRKN protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [BECN1 protein binds to PRKN protein]; PINK1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]
[Carbonyl Cyanide m-Chlorophenyl Hydrazone co-treated with PRKN protein] results in increased expression of PINK1 protein; BECN1 protein inhibits the reaction [BECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]]; Carbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [AMBRA1 protein binds to PRKN protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [BECN1 protein binds to PRKN protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [PIK3C3 protein binds to PRKN protein]; Tretinoin affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the expression of PRKN protein alternative form]
CTD PMID:16517603 PMID:22872702 PMID:24879156 PMID:26070385 PMID:28673964 More... NCBI chr 1:48,688,651...49,882,520 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [Sodium Chloride results in increased expression of PTGS2 protein]
Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA]; Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [Glucose results in increased expression of PTGS2 protein]
CTD PMID:14514642 PMID:16024921 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rbm3 RNA binding motif protein 3 decreases expression ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of RBM3 mRNA CTD PMID:15075239 NCBI chr  X:14,348,909...14,352,387
Ensembl chr  X:14,348,910...14,353,580
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit increases expression ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of REL protein CTD PMID:15978749 NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Carbonyl Cyanide m-Chlorophenyl Hydrazone co-treated with Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of RELA protein; Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of RELA protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased phosphorylation of RELA protein] CTD PMID:33524445 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO [[Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [SQSTM1 protein binds to KEAP1 protein]] promotes the reaction [KEAP1 protein binds to NFE2L2 protein]] which results in decreased activity of NFE2L2 protein; [Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [SQSTM1 protein binds to KEAP1 protein]] promotes the reaction [KEAP1 protein binds to NFE2L2 protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [SQSTM1 protein binds to KEAP1 protein] CTD PMID:30715550 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Timm23 translocase of inner mitochondrial membrane 23 decreases expression ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of TIMM23 protein CTD PMID:29371327 NCBI chr16:7,410,308...7,436,392
Ensembl chr16:7,409,688...7,436,379
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [Testosterone results in increased expression of TNF mRNA]
Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TNF mRNA]
CTD PMID:24658017 PMID:33524445 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
chlorothalonil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acly ATP citrate lyase decreases expression
multiple interactions
ISO tetrachloroisophthalonitrile results in decreased expression of ACLY mRNA
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of ACLY mRNA
CTD PMID:33246813 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
JBrowse link
G Acot1 acyl-CoA thioesterase 1 decreases expression
multiple interactions
ISO tetrachloroisophthalonitrile results in decreased expression of ACOT1 mRNA
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of ACOT1 mRNA
CTD PMID:33246813 NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163
JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions
decreases expression
ISO [procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of ACOX1 mRNA
tetrachloroisophthalonitrile results in decreased expression of ACOX1 mRNA
CTD PMID:33246813 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of ACTA2 mRNA CTD PMID:32289622 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions EXP tetrachloroisophthalonitrile binds to and results in increased activity of AHR protein CTD PMID:14636698 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Angpt4 angiopoietin 4 multiple interactions ISO [tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of ANGPT4 mRNA CTD PMID:33246813 NCBI chr 3:140,420,389...140,454,213
Ensembl chr 3:140,420,389...140,453,583
JBrowse link
G Ano1 anoctamin 1 increases expression ISO tetrachloroisophthalonitrile results in increased expression of ANO1 mRNA CTD PMID:33246813 NCBI chr 1:199,751,439...199,900,099
Ensembl chr 1:199,751,439...199,900,069
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO tetrachloroisophthalonitrile results in increased expression of BAX protein CTD PMID:30586609 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of BCL2 protein CTD PMID:30586609 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bmp15 bone morphogenetic protein 15 decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of BMP15 protein CTD PMID:30586609 NCBI chr  X:16,169,123...16,174,187
Ensembl chr  X:16,169,123...16,174,187
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of CCL2 mRNA CTD PMID:32289622 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of CCL4 mRNA CTD PMID:32289622 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Cftr CF transmembrane conductance regulator decreases expression
multiple interactions
ISO tetrachloroisophthalonitrile results in decreased expression of CFTR protein
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of CFTR protein; [tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of CFTR mRNA
CTD PMID:33246813 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of COL1A1 mRNA; tetrachloroisophthalonitrile metabolite results in increased expression of COL1A1 protein CTD PMID:32289622 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression
multiple interactions
ISO tetrachloroisophthalonitrile results in decreased expression of CPT1A mRNA
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of CPT1A mRNA
CTD PMID:33246813 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of CXCL2 mRNA CTD PMID:32289622 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of CYP11A1 protein CTD PMID:30586609 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Defa10 defensin alpha 10 multiple interactions ISO [tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of DEFA3 mRNA CTD PMID:33246813 NCBI chr16:70,514,248...70,515,024
Ensembl chr16:70,514,248...70,515,024
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 multiple interactions
decreases expression
ISO [procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of DGAT1 mRNA
tetrachloroisophthalonitrile results in decreased expression of DGAT1 mRNA
CTD PMID:33246813 NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299
JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 decreases expression
multiple interactions
ISO tetrachloroisophthalonitrile results in decreased expression of DGAT2 mRNA
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of DGAT2 mRNA
CTD PMID:33246813 NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428
JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO tetrachloroisophthalonitrile results in decreased activity of DIO1 protein CTD PMID:29228274 PMID:30561685 NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
JBrowse link
G Dio2 iodothyronine deiodinase 2 decreases activity ISO tetrachloroisophthalonitrile results in decreased activity of DIO2 protein CTD PMID:30561685 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
JBrowse link
G Dio3 iodothyronine deiodinase 3 decreases activity ISO tetrachloroisophthalonitrile results in decreased activity of DIO3 protein CTD PMID:30561685 NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660
JBrowse link
G Egfr epidermal growth factor receptor decreases phosphorylation ISO tetrachloroisophthalonitrile results in decreased phosphorylation of EGFR protein CTD PMID:28426875 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 increases activity ISO tetrachloroisophthalonitrile results in increased activity of ERBB2 protein CTD PMID:11222871 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Fabp1 fatty acid binding protein 1 decreases expression
multiple interactions
ISO tetrachloroisophthalonitrile results in decreased expression of FABP1 mRNA
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of FABP1 mRNA
CTD PMID:33246813 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
JBrowse link
G Fasn fatty acid synthase decreases expression
multiple interactions
ISO tetrachloroisophthalonitrile results in decreased expression of FASN mRNA
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of FASN mRNA
CTD PMID:33246813 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fshr follicle stimulating hormone receptor decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of FSHR protein CTD PMID:30586609 NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785
JBrowse link
G Gck glucokinase multiple interactions
decreases expression
ISO [procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of GCK mRNA
tetrachloroisophthalonitrile results in decreased expression of GCK mRNA
CTD PMID:33246813 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
JBrowse link
G Gdf9 growth differentiation factor 9 decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of GDF9 protein CTD PMID:30586609 NCBI chr10:37,589,200...37,599,970
Ensembl chr10:37,595,679...37,599,672
JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of GJA1 protein CTD PMID:30586609 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial multiple interactions
decreases expression
ISO [procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of GPAM mRNA
tetrachloroisophthalonitrile results in decreased expression of GPAM mRNA
CTD PMID:33246813 NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of HSD17B4 protein CTD PMID:30586609 NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of HSD3B1 protein CTD PMID:30586609 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of IL1A mRNA CTD PMID:32289622 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of IL1B mRNA CTD PMID:32289622 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of IL6 mRNA CTD PMID:32289622 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Klf4 Kruppel like factor 4 multiple interactions
increases expression
ISO [tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of KLF4 mRNA
tetrachloroisophthalonitrile results in increased expression of KLF4 mRNA
CTD PMID:33246813 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO tetrachloroisophthalonitrile results in decreased phosphorylation of MAPK1 protein CTD PMID:28426875 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO tetrachloroisophthalonitrile results in decreased phosphorylation of MAPK3 protein CTD PMID:28426875 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mep1b meprin A subunit beta multiple interactions
increases expression
ISO [tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of MEP1B mRNA
tetrachloroisophthalonitrile results in increased expression of MEP1B mRNA
CTD PMID:33246813 NCBI chr18:12,366,126...12,392,840
Ensembl chr18:12,365,289...12,392,840
JBrowse link
G Mif macrophage migration inhibitory factor decreases expression ISO tetrachloroisophthalonitrile metabolite results in decreased expression of MIF mRNA CTD PMID:32289622 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
JBrowse link
G Mlxip MLX interacting protein multiple interactions ISO [procymidone co-treated with tetrachloroisophthalonitrile] results in increased expression of MLXIP mRNA CTD PMID:33246813 NCBI chr12:33,128,524...33,192,300
Ensembl chr12:33,128,520...33,192,374
JBrowse link
G Mmp1 matrix metallopeptidase 1 decreases expression ISO tetrachloroisophthalonitrile metabolite results in decreased expression of MMP1 mRNA CTD PMID:32289622 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp3 matrix metallopeptidase 3 decreases expression ISO tetrachloroisophthalonitrile metabolite results in decreased expression of MMP3 mRNA CTD PMID:32289622 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of MMP9 mRNA CTD PMID:32289622 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions ISO [procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of MTTP mRNA CTD PMID:33246813 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
JBrowse link
G Muc1 mucin 1, cell surface associated increases expression ISO tetrachloroisophthalonitrile results in increased expression of MUC1 mRNA CTD PMID:33246813 NCBI chr 2:174,635,559...174,640,738
Ensembl chr 2:174,635,995...174,640,733
JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming increases expression
decreases expression
multiple interactions
ISO tetrachloroisophthalonitrile results in increased expression of MUC2 mRNA
tetrachloroisophthalonitrile results in decreased expression of MUC2 protein
[tetrachloroisophthalonitrile co-treated with procymidone] results in decreased expression of MUC2 protein
CTD PMID:33246813 NCBI chr 1:196,796,257...196,831,740 JBrowse link
G Muc3 mucin 3, intestinal multiple interactions ISO [tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of MUC3 mRNA CTD PMID:33246813 NCBI chr12:19,527,251...19,536,924 JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO tetrachloroisophthalonitrile results in increased activity of NR1I2 protein CTD PMID:20143881 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Pklr pyruvate kinase L/R decreases expression
multiple interactions
ISO tetrachloroisophthalonitrile results in decreased expression of PKLR mRNA
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of PKLR mRNA
CTD PMID:33246813 NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
JBrowse link
G Pla2g4a phospholipase A2 group IVA multiple interactions ISO [tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of PLA2G4A mRNA CTD PMID:33246813 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression
multiple interactions
ISO tetrachloroisophthalonitrile results in decreased expression of PPARA mRNA
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of PPARA mRNA
CTD PMID:33246813 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression
multiple interactions
ISO tetrachloroisophthalonitrile results in decreased expression of PPARG mRNA
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of PPARG mRNA
CTD PMID:33246813 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of PTGS2 mRNA CTD PMID:32289622 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rad51 RAD51 recombinase increases expression ISO tetrachloroisophthalonitrile results in increased expression of RAD51 protein CTD PMID:30586609 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of S100A8 mRNA CTD PMID:32289622 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
JBrowse link
G S100a9 S100 calcium binding protein A9 decreases expression ISO tetrachloroisophthalonitrile metabolite results in decreased expression of S100A9 mRNA CTD PMID:32289622 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions
decreases expression
ISO [procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of SCD1 mRNA
tetrachloroisophthalonitrile results in decreased expression of SCD1 mRNA
CTD PMID:33246813 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Slc12a2 solute carrier family 12 member 2 multiple interactions ISO [tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of SLC12A2 mRNA CTD PMID:33246813 NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440
JBrowse link
G Slc26a3 solute carrier family 26 member 3 multiple interactions
increases expression
ISO [tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of SLC26A3 mRNA
tetrachloroisophthalonitrile results in increased expression of SLC26A3 mRNA
CTD PMID:33246813 NCBI chr 6:48,023,892...48,064,829
Ensembl chr 6:48,023,892...48,064,772
JBrowse link
G Slc26a6 solute carrier family 26 member 6 increases expression ISO tetrachloroisophthalonitrile results in increased expression of SLC26A6 mRNA CTD PMID:33246813 NCBI chr 8:109,558,968...109,569,778
Ensembl chr 8:109,559,642...109,569,778
JBrowse link
G Slc27a2 solute carrier family 27 member 2 decreases expression
multiple interactions
ISO tetrachloroisophthalonitrile results in decreased expression of SLC27A2 mRNA
[procymidone co-treated with tetrachloroisophthalonitrile] results in decreased expression of SLC27A2 mRNA
CTD PMID:33246813 NCBI chr 3:113,804,728...113,842,208
Ensembl chr 3:113,804,728...113,842,208
JBrowse link
G Slc9a3 solute carrier family 9 member A3 multiple interactions
increases expression
ISO [tetrachloroisophthalonitrile co-treated with procymidone] results in increased expression of SLC9A3 mRNA
tetrachloroisophthalonitrile results in increased expression of SLC9A3 mRNA
CTD PMID:33246813 NCBI chr 1:29,124,633...29,167,912
Ensembl chr 1:29,124,674...29,167,417
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases activity ISO tetrachloroisophthalonitrile results in decreased activity of TGFB1 protein CTD PMID:31652400 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tlr4 toll-like receptor 4 increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of TLR4 mRNA CTD PMID:32289622 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor increases expression ISO tetrachloroisophthalonitrile metabolite results in increased expression of TNF mRNA CTD PMID:32289622 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
oxomalononitrile term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases response to substance
ISO PK 11195 inhibits the reaction [BCL2 protein results in decreased susceptibility to mesoxalonitrile] CTD PMID:12730627 NCBI chr13:22,689,783...22,853,920 JBrowse link
U0126 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions EXP U0126 inhibits the reaction [17alpha-ethynylestradiol increases phosphorylation of Prkaa1 in primary hepatocytes] RGD PMID:27090119 RGD:15090804 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    chemical entity 19821
      group 19741
        pseudohalo group 3490
          cyano group 3490
            nitrile 3490
              dinitrile 170
                1,4-diamino-2,3-dicyano-1,4-bis(phenylthio)butadiene 0
                4-(dicyanomethylene)-2-methyl-6-(4-(dimethylamino)styryl)-4H-pyran 0
                N-[(E)-\{[(Z)-2-amino-1,2-dicyanoethenyl]imino\}methyl]phenylalanine 0
                NK372135A 0
                NK372135B 0
                NK372135C 0
                U0126 + 1
                acene dinitrile + 0
                chlorothalonil 68
                dithianon 0
                etravirine 0
                iminodiacetonitrile 0
                malononitrile + 108
                oxalonitrile 0
                trans-2-[3-(4-tert-butylphenyl)-2-methyl-2-propenylidene]malononitrile 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            one-carbon compound 17665
                              hydrogen cyanide 3493
                                cyanides 3493
                                  nitrile 3490
                                    dinitrile 170
                                      1,4-diamino-2,3-dicyano-1,4-bis(phenylthio)butadiene 0
                                      4-(dicyanomethylene)-2-methyl-6-(4-(dimethylamino)styryl)-4H-pyran 0
                                      N-[(E)-\{[(Z)-2-amino-1,2-dicyanoethenyl]imino\}methyl]phenylalanine 0
                                      NK372135A 0
                                      NK372135B 0
                                      NK372135C 0
                                      U0126 + 1
                                      acene dinitrile + 0
                                      chlorothalonil 68
                                      dithianon 0
                                      etravirine 0
                                      iminodiacetonitrile 0
                                      malononitrile + 108
                                      oxalonitrile 0
                                      trans-2-[3-(4-tert-butylphenyl)-2-methyl-2-propenylidene]malononitrile 0
paths to the root