thioester - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	thioester	go back to main search page
Accession:	CHEBI:51277	browse the term
Definition:	A compound of general formula RC(=O)SR'. Compare with thionoester, RC(=S)OR'.
Synonyms:	related_synonym:	Formula=COSR2; SMILES=[]C(=O)S[]; thio ester; thioesters; thiol ester

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Rat (194) Mouse (199) Human (192) Chinchilla (0) Bonobo (0) Dog (7) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (194)

acetoacetyl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

hydroxysteroid (17-beta) dehydrogenase 2

affects binding

acetoacetyl CoA binds to HSD17B2 protein

NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202

acetyl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP citrate lyase

increases abundance
affects abundance

ACLY protein results in increased abundance of Acetyl Coenzyme A
ACLY protein affects the abundance of Acetyl Coenzyme A

PMID:28077572 PMID:36933457

NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320

G

amyloid beta precursor protein

affects localization
increases secretion
multiple interactions

APP protein affects the localization of Acetyl Coenzyme A
Acetyl Coenzyme A results in increased secretion of APP protein modified form
Acetyl Coenzyme A inhibits the reaction [Hydrogen Peroxide results in decreased secretion of APP protein modified form]
IL1B protein affects the reaction [APP protein affects the localization of Acetyl Coenzyme A]

PMID:16122837 PMID:22906069

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

carnitine O-acetyltransferase

decreases activity

Acetyl Coenzyme A deficiency results in decreased activity of CRAT protein

NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255

G

ERCC excision repair 6, chromatin remodeling factor

decreases abundance
multiple interactions

ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A
3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A]

NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions

[Fluoxetine results in decreased expression of G6PC1 protein] which results in increased abundance of Acetyl Coenzyme A

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

interleukin 1 beta

multiple interactions

IL1B protein affects the reaction [APP protein affects the localization of Acetyl Coenzyme A]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

lysine acetyltransferase 2B

affects binding

Acetyl Coenzyme A binds to KAT2B protein

NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064

G

meteorin-like, glial cell differentiation regulator

multiple interactions

METRNL protein inhibits the reaction [Dietary Fats results in decreased abundance of Acetyl Coenzyme A]

NCBI chr10:106,963,880...106,977,875
Ensembl chr10:106,963,880...106,977,869

G

N-acetyltransferase 1

multiple interactions
affects binding

[NQO1 protein co-treated with NADP co-treated with Acetyl Coenzyme A co-treated with NAT1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone; Acetyl Coenzyme A inhibits the reaction [Cyanamide results in decreased activity of NAT1 protein]; Acetyl Coenzyme A inhibits the reaction [Iodoacetamide results in decreased activity of NAT1 protein]
Acetyl Coenzyme A binds to NAT1 protein

PMID:20545351 PMID:22835378

NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520

G

N-acetyltransferase 2

multiple interactions

[NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]; [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[SULT1A2 protein co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]

NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

[NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]; [NQO1 protein co-treated with NADP co-treated with Acetyl Coenzyme A co-treated with NAT1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

acryloyl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

enoyl-CoA hydratase, short chain 1

increases abundance

ECHS1 gene mutant form results in increased abundance of acryloyl-coenzyme A

NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884

G

3-hydroxyisobutyryl-CoA hydrolase

increases abundance

HIBCH gene mutant form results in increased abundance of acryloyl-coenzyme A

NCBI chr 9:48,590,097...48,669,896
Ensembl chr 9:48,590,099...48,669,824

arachidonoyl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

peroxisome proliferator activated receptor alpha

multiple interactions

arachidonyl-coenzyme A binds to and results in increased activity of PPARA protein

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

benfotiamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glutamate cysteine ligase, modifier subunit

multiple interactions
increases expression

NFE2L2 protein affects the reaction [benphothiamine metabolite results in increased expression of GCLM mRNA]; NFE2L2 protein affects the reaction [benphothiamine results in increased expression of GCLM mRNA]
benphothiamine metabolite results in increased expression of GCLM mRNA; benphothiamine results in increased expression of GCLM mRNA

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

glutathione-disulfide reductase

multiple interactions
increases expression

NFE2L2 protein affects the reaction [benphothiamine results in increased expression of GSR mRNA]

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

heme oxygenase 1

increases expression
multiple interactions

benphothiamine metabolite results in increased expression of HMOX1 mRNA; benphothiamine results in increased expression of HMOX1 mRNA
benphothiamine inhibits the reaction [MAPT protein results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [benphothiamine metabolite results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [benphothiamine results in increased expression of HMOX1 mRNA]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

interleukin 1 beta

multiple interactions

[benphothiamine co-treated with MAPT protein] results in decreased expression of IL1B protein

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

microtubule-associated protein tau

decreases phosphorylation
multiple interactions

benphothiamine results in decreased phosphorylation of MAPT protein
[benphothiamine co-treated with MAPT protein] results in decreased expression of IL1B protein; [benphothiamine co-treated with MAPT protein] results in decreased expression of NOS2 protein; [benphothiamine co-treated with MAPT protein] results in decreased expression of PTGS2 protein; [benphothiamine co-treated with MAPT protein] results in decreased expression of RELA protein; [benphothiamine co-treated with MAPT protein] results in decreased expression of TNF protein; [benphothiamine co-treated with MAPT protein] results in increased expression of NQO1 mRNA; [benphothiamine co-treated with MAPT protein] results in increased expression of TXN mRNA; benphothiamine inhibits the reaction [MAPT protein results in decreased activity of TKT protein]; benphothiamine inhibits the reaction [MAPT protein results in decreased expression of NOS2 mRNA]; benphothiamine inhibits the reaction [MAPT protein results in decreased expression of PPARGC1A protein]; benphothiamine inhibits the reaction [MAPT protein results in decreased expression of SOD1 protein]; benphothiamine inhibits the reaction [MAPT protein results in increased expression of HMOX1 mRNA]

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

G

NFE2 like bZIP transcription factor 2

multiple interactions

NFE2L2 protein affects the reaction [benphothiamine metabolite results in increased expression of GCLM mRNA]; NFE2L2 protein affects the reaction [benphothiamine metabolite results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [benphothiamine metabolite results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [benphothiamine results in increased expression of GCLM mRNA]; NFE2L2 protein affects the reaction [benphothiamine results in increased expression of GSR mRNA]; NFE2L2 protein affects the reaction [benphothiamine results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [benphothiamine results in increased expression of NQO1 mRNA]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nitric oxide synthase 2

multiple interactions

[benphothiamine co-treated with MAPT protein] results in decreased expression of NOS2 protein; benphothiamine inhibits the reaction [MAPT protein results in decreased expression of NOS2 mRNA]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NAD(P)H quinone dehydrogenase 1

increases expression
multiple interactions

benphothiamine metabolite results in increased expression of NQO1 mRNA; benphothiamine results in increased expression of NQO1 mRNA
[benphothiamine co-treated with MAPT protein] results in increased expression of NQO1 mRNA; NFE2L2 protein affects the reaction [benphothiamine metabolite results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [benphothiamine results in increased expression of NQO1 mRNA]

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

PPARG coactivator 1 alpha

multiple interactions

benphothiamine inhibits the reaction [MAPT protein results in decreased expression of PPARGC1A protein]

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[benphothiamine co-treated with MAPT protein] results in decreased expression of PTGS2 protein

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

[benphothiamine co-treated with MAPT protein] results in decreased expression of RELA protein

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

superoxide dismutase 1

multiple interactions

benphothiamine inhibits the reaction [MAPT protein results in decreased expression of SOD1 protein]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

transketolase

multiple interactions

[benphothiamine co-treated with Streptozocin] results in increased activity of TKT protein
benphothiamine inhibits the reaction [MAPT protein results in decreased activity of TKT protein]

PMID:12592403 PMID:29860433

NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698

G

tumor necrosis factor

multiple interactions

[benphothiamine co-treated with MAPT protein] results in decreased expression of TNF protein

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

thioredoxin 1

multiple interactions

[benphothiamine co-treated with MAPT protein] results in increased expression of TXN mRNA

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

butyryl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

lysine acetyltransferase 2B

affects binding

butyryl-coenzyme A binds to KAT2B protein

NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064

decanoyl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

hydroxysteroid dehydrogenase like 2

multiple interactions

[decanoyl-coenzyme A co-treated with NADP] binds to HSDL2 protein

NCBI chr 5:74,443,933...74,479,104
Ensembl chr 5:74,443,872...74,479,839

G

peroxisomal trans-2-enoyl-CoA reductase

multiple interactions

[decanoyl-coenzyme A co-treated with NADP] binds to PECR protein

NCBI chr 9:73,897,877...73,926,511
Ensembl chr 9:73,897,880...73,926,511

Dithiopyr

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

androgen receptor

multiple interactions

dithiopyr inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression

dithiopyr results in increased expression of CYP3A4 mRNA

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

estrogen receptor 1

multiple interactions

dithiopyr binds to and results in increased activity of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

dithiopyr binds to and results in increased activity of NR1I2 protein

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

peroxisome proliferator-activated receptor gamma

multiple interactions

dithiopyr binds to and results in increased activity of PPARG protein

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

fluticasone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases secretion
increases expression
multiple interactions

ABCB1 protein results in increased secretion of Fluticasone
Fluticasone results in increased expression of ABCB1 protein
Elacridar inhibits the reaction [ABCB1 protein results in increased secretion of Fluticasone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Fluticasone]

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

annexin A1

affects localization

Fluticasone affects the localization of ANXA1 protein

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

G

androgen receptor

multiple interactions

Fluticasone binds to and results in increased activity of AR protein

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

bone gamma-carboxyglutamate protein

increases expression

Fluticasone results in increased expression of BGLAP protein

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

caspase 3

multiple interactions

[Fluticasone co-treated with Salmeterol Xinafoate] results in increased activity of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions

[Fluticasone co-treated with Salmeterol Xinafoate] results in increased activity of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

C-C motif chemokine ligand 11

multiple interactions

Fluticasone inhibits the reaction [RELA protein binds to CCL11 promoter]; Fluticasone inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased expression of CCL11 protein]; Fluticasone promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]]; Fluticasone promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL11 protein]]

NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926

G

C-C motif chemokine ligand 2

multiple interactions

Fluticasone inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; Fluticasone promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 5

multiple interactions

Fluticasone inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; Fluticasone inhibits the reaction [TNF protein results in increased secretion of CCL5 mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased secretion of CCL5 protein]

PMID:9150321 PMID:10903220 PMID:14643170

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

colony stimulating factor 2

multiple interactions
decreases secretion
increases activity

Fluticasone inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]
Fluticasone results in decreased secretion of CSF2 protein
Fluticasone results in increased activity of CSF2 protein

PMID:10460758 PMID:10868704 PMID:11730731

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

C-X-C motif chemokine ligand 1

multiple interactions

Fluticasone inhibits the reaction [Particulate Matter results in increased expression of CXCL1 mRNA]; Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]]

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 3

multiple interactions

Fluticasone inhibits the reaction [Particulate Matter results in increased expression of CXCL1 mRNA]; Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]]

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity

Fluticasone results in decreased activity of CYP3A4 protein

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 9

affects response to substance
multiple interactions
increases expression
decreases activity
increases metabolic processing

CYP3A5 protein affects the susceptibility to Fluticasone
Ketoconazole inhibits the reaction [Fluticasone results in increased expression of CYP3A5 mRNA]
Fluticasone results in decreased activity of CYP3A5 protein
CYP3A5 protein results in increased metabolism of Fluticasone

PMID:20707410 PMID:24555085

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

dual specificity phosphatase 1

multiple interactions
increases expression

[Fluticasone co-treated with Salmeterol Xinafoate] results in increased expression of DUSP1 mRNA; [Fluticasone co-treated with Tetradecanoylphorbol Acetate] results in increased expression of DUSP1 mRNA; Salmeterol Xinafoate promotes the reaction [Fluticasone results in increased expression of DUSP1 mRNA]

PMID:15860753 PMID:15862954

NCBI chr10:16,680,478...16,683,275

G

eosinophil peroxidase

multiple interactions

Fluticasone inhibits the reaction [sephadex results in increased expression of EPX protein]

NCBI chr10:72,666,865...72,677,952
Ensembl chr10:72,666,865...72,677,952

G

gamma-glutamyltransferase 5

multiple interactions
increases activity
increases expression

[Fluticasone results in increased activity of GGT5 protein] which results in increased metabolism of Leukotriene C4
Fluticasone results in increased expression of GGT5 mRNA

NCBI chr20:13,043,255...13,071,523
Ensembl chr20:13,043,257...13,071,450

G

intercellular adhesion molecule 1

multiple interactions

Fluticasone inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interferon gamma

multiple interactions

Fluticasone inhibits the reaction [Amb a I protein, Ambrosia artemisiifolia results in increased expression of IFNG mRNA]

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 1 beta

multiple interactions

Fluticasone inhibits the reaction [IL1B protein results in increased expression of SELE mRNA]; Fluticasone inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]; Fluticasone inhibits the reaction [Particulate Matter results in increased expression of IL1B mRNA]; Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of IL1B protein]; Mifepristone inhibits the reaction [Fluticasone inhibits the reaction [IL1B protein results in increased expression of SELE mRNA]]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of IL1B protein]]

PMID:9371735 PMID:10460758 PMID:31822346

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

multiple interactions

Fluticasone inhibits the reaction [Amb a I protein, Ambrosia artemisiifolia results in increased expression of IL2 mRNA]

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 4

multiple interactions

Fluticasone inhibits the reaction [Amb a I protein, Ambrosia artemisiifolia results in increased expression of IL4 mRNA]

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 5

decreases expression
multiple interactions

Fluticasone results in decreased expression of IL5 protein
Fluticasone inhibits the reaction [Amb a I protein, Ambrosia artemisiifolia results in increased expression of IL5 mRNA]

PMID:10075860 PMID:15634547

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

G

interleukin 6

multiple interactions

Fluticasone inhibits the reaction [Amb a I protein, Ambrosia artemisiifolia results in increased expression of IL6 mRNA]; Fluticasone inhibits the reaction [Particulate Matter results in increased expression of IL6 mRNA]; Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]]

PMID:10075860 PMID:31822346

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 1

multiple interactions

Fluticasone inhibits the reaction [Colforsin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Fluticasone inhibits the reaction [Glucose results in increased secretion of INS1 protein]

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

nuclear factor kappa B subunit 1

multiple interactions

Fluticasone inhibits the reaction [Particulate Matter results in increased expression of NFKB1 protein]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased expression of NFKB1 protein]]

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

multiple interactions

[Fluticasone co-treated with Salmeterol Xinafoate] results in decreased phosphorylation of NFKBIA protein

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nuclear receptor subfamily 1, group I, member 2

increases activity

Fluticasone results in increased activity of NR1I2 protein

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 3, group C, member 1

multiple interactions
affects binding
affects localization

[Fluticasone co-treated with Salmeterol Xinafoate] affects the localization of and results in increased activity of NR3C1 protein; [Fluticasone co-treated with Salmeterol Xinafoate] affects the localization of NR3C1 protein; [Fluticasone co-treated with Tetradecanoylphorbol Acetate] affects the localization of NR3C1 protein; Fluticasone affects the localization of and results in increased activity of NR3C1 protein; Fluticasone promotes the reaction [15-deoxyprostaglandin J2 promotes the reaction [NR3C1 protein binds to PPARG protein]]; Salmeterol Xinafoate promotes the reaction [[Fluticasone co-treated with Tetradecanoylphorbol Acetate] affects the localization of NR3C1 protein]; Salmeterol Xinafoate promotes the reaction [Fluticasone affects the localization of and results in increased activity of NR3C1 protein]; Salmeterol Xinafoate promotes the reaction [Fluticasone affects the localization of NR3C1 protein]
Fluticasone binds to NR3C1 protein

PMID:7878687 PMID:15531761 PMID:15536434 PMID:15860753 PMID:15862954 More...

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

progesterone receptor

multiple interactions

Fluticasone binds to and results in increased activity of PGR protein

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

phospholipase A2 group 4A

affects localization

Fluticasone affects the localization of PLA2G4A protein

NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266

G

paraoxonase 1

decreases activity

Fluticasone results in decreased activity of PON1 protein

NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360

G

peroxisome proliferator-activated receptor gamma

multiple interactions

Fluticasone promotes the reaction [15-deoxyprostaglandin J2 promotes the reaction [NR3C1 protein binds to PPARG protein]]

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

protein kinase C, alpha

decreases expression

Fluticasone results in decreased expression of PRKCA protein

NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Fluticasone inhibits the reaction [Particulate Matter results in increased expression of RELA protein]; Fluticasone inhibits the reaction [RELA protein binds to CCL11 promoter]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased expression of RELA protein]]

PMID:15531761 PMID:31822346

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

selectin E

multiple interactions

Fluticasone inhibits the reaction [IL1B protein results in increased expression of SELE mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased expression of SELE protein]; Mifepristone inhibits the reaction [Fluticasone inhibits the reaction [IL1B protein results in increased expression of SELE mRNA]]

NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741

G

solute carrier family 22 member 3

multiple interactions

Fluticasone inhibits the reaction [SLC22A3 protein results in increased uptake of Formoterol Fumarate]; SLC22A3 protein results in increased susceptibility to [Fluticasone results in decreased transport of Formoterol Fumarate]

PMID:17920670 PMID:21914487

NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612

G

secretory leukocyte peptidase inhibitor

multiple interactions
increases expression

[Fluticasone co-treated with Salmeterol Xinafoate] results in increased expression of SLPI mRNA; Salmeterol Xinafoate promotes the reaction [Fluticasone results in increased expression of SLPI mRNA]

PMID:15860753 PMID:15862954

NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453

G

signal transducer and activator of transcription 3

multiple interactions

Fluticasone inhibits the reaction [Particulate Matter results in increased phosphorylation of STAT3 protein]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased phosphorylation of STAT3 protein]]

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

tumor necrosis factor

multiple interactions

Fluticasone inhibits the reaction [Amb a I protein, Ambrosia artemisiifolia results in increased expression of TNF mRNA]; Fluticasone inhibits the reaction [Particulate Matter results in increased expression of TNF mRNA]; Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]; Fluticasone inhibits the reaction [TNF protein results in increased acetylation of H4C16 protein]; Fluticasone inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased expression of CCL11 protein]; Fluticasone inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; Fluticasone inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; Fluticasone inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Fluticasone inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Fluticasone inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased expression of SELE protein]; Fluticasone inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Fluticasone inhibits the reaction [TNF protein results in increased secretion of CCL5 mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased secretion of CCL5 protein]; Fluticasone inhibits the reaction [TNF protein results in increased secretion of CXCL8 mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]; Fluticasone promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]]; Fluticasone promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL11 protein]]; Fluticasone promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased expression of NFKB1 protein]]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased expression of RELA protein]]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased phosphorylation of STAT3 protein]]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of IL1B protein]]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]]

PMID:9150321 PMID:9371735 PMID:10075860 PMID:10100995 PMID:10903220 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

vascular cell adhesion molecule 1

multiple interactions
decreases stability

Fluticasone inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
Fluticasone results in decreased stability of VCAM1 mRNA

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

glutaryl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-CoA thioesterase 4

affects hydrolysis

ACOT4 protein affects the hydrolysis of glutaryl-coenzyme A

NCBI chr 6:103,668,699...103,674,037
Ensembl chr 6:103,668,753...103,673,917

G

acyl-CoA thioesterase 8

affects hydrolysis

ACOT8 protein affects the hydrolysis of glutaryl-coenzyme A

NCBI chr 3:153,531,192...153,542,851
Ensembl chr 3:153,531,193...153,542,851

hexanoyl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

peroxisomal trans-2-enoyl-CoA reductase

multiple interactions

[hexanoyl-coenzyme A co-treated with NADP] binds to PECR protein

NCBI chr 9:73,897,877...73,926,511
Ensembl chr 9:73,897,880...73,926,511

isobutyryl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

lysine acetyltransferase 2B

affects binding

isobutyryl-coenzyme A binds to KAT2B protein

NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064

lauroyl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glutathione S-transferase alpha 1

multiple interactions

lauroyl-coenzyme A binds to and results in decreased activity of GSTA1 protein

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

hydroxysteroid dehydrogenase like 2

multiple interactions

[lauroyl-coenzyme A co-treated with NADP] binds to HSDL2 protein

NCBI chr 5:74,443,933...74,479,104
Ensembl chr 5:74,443,872...74,479,839

G

peroxisomal trans-2-enoyl-CoA reductase

multiple interactions

[lauroyl-coenzyme A co-treated with NADP] binds to PECR protein

NCBI chr 9:73,897,877...73,926,511
Ensembl chr 9:73,897,880...73,926,511

malonyl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

malonyl-CoA decarboxylase

multiple interactions

PPARA protein promotes the reaction [MLYCD protein results in decreased abundance of Malonyl Coenzyme A]

NCBI chr19:47,447,931...47,463,794
Ensembl chr19:47,447,970...47,463,793

G

peroxisome proliferator activated receptor alpha

multiple interactions

PPARA protein promotes the reaction [MLYCD protein results in decreased abundance of Malonyl Coenzyme A]

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

methacrylyl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

enoyl-CoA hydratase, short chain 1

increases abundance

ECHS1 gene mutant form results in increased abundance of methacrylyl-coenzyme A

NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884

G

3-hydroxyisobutyryl-CoA hydrolase

increases abundance

HIBCH gene mutant form results in increased abundance of methacrylyl-coenzyme A

NCBI chr 9:48,590,097...48,669,896
Ensembl chr 9:48,590,099...48,669,824

methomyl

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

multiple interactions
decreases activity

methamidophos promotes the reaction [Methomyl results in decreased activity of ACHE protein]; Methomyl promotes the reaction [methamidophos results in decreased activity of ACHE protein]

PMID:8134223 PMID:19371631 PMID:19934164 PMID:21251949 PMID:23962483 More...

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

BCL2 associated X, apoptosis regulator

increases expression

Methomyl results in increased expression of BAX mRNA

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

butyrylcholinesterase

multiple interactions

[Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

BCL2, apoptosis regulator

decreases expression

Methomyl results in decreased expression of BCL2 mRNA

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

increases expression

Methomyl results in increased expression of CASP3 mRNA

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

cytochrome P450, family 19, subfamily a, polypeptide 1

increases activity

Methomyl results in increased activity of CYP19A1 protein

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

estrogen receptor 1

multiple interactions

Methomyl inhibits the reaction [Estradiol results in increased activity of ESR1 protein]

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

follicle stimulating hormone subunit beta

increases expression

Methomyl results in increased expression of FSHB protein

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

heat shock protein 90 beta family member 1

decreases expression

Methomyl results in decreased expression of HSP90B1 protein

NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788

G

heat shock protein family A (Hsp70) member 1A

decreases expression

Methomyl results in decreased expression of HSPA1A protein

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 5

increases expression

Methomyl results in increased expression of HSPA5 protein

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family A (Hsp70) member 8

decreases expression

Methomyl results in decreased expression of HSPA8 protein

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

kynurenine aminotransferase 1

decreases activity

Methomyl results in decreased activity of KYAT1 protein

NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355

G

kynureninase

decreases activity

Methomyl results in decreased activity of KYNU protein

NCBI chr 3:27,778,646...27,929,470
Ensembl chr 3:27,778,772...27,929,488

G

luteinizing hormone subunit beta

increases expression

Methomyl results in increased expression of LHB protein

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

progesterone receptor

multiple interactions

Methomyl inhibits the reaction [Progesterone results in increased activity of PGR protein]

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

prolactin

increases expression

Methomyl results in increased expression of PRL protein

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

S100 calcium binding protein A1

multiple interactions

Methomyl results in increased expression of and affects the localization of S100A1 protein

NCBI chr 2:175,993,922...175,998,765
Ensembl chr 2:175,993,922...175,999,544

G

tumor protein, translationally-controlled 1

increases expression

Methomyl results in increased expression of TPT1 protein

NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625

myristoyl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

diazepam binding inhibitor

affects binding

S-tetradecanoyl-coenzyme A binds to DBI protein

NCBI chr13:31,241,466...31,249,853
Ensembl chr13:31,206,988...31,268,693

G

glutathione S-transferase alpha 1

multiple interactions

S-tetradecanoyl-coenzyme A binds to and results in decreased activity of GSTA1 protein

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

peroxisome proliferator activated receptor alpha

multiple interactions

S-tetradecanoyl-coenzyme A binds to and results in increased activity of PPARA protein

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

oleoyl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glutathione S-transferase alpha 1

multiple interactions

oleoyl-coenzyme A binds to and results in decreased activity of GSTA1 protein

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

peroxisome proliferator activated receptor alpha

multiple interactions

oleoyl-coenzyme A binds to and results in increased activity of PPARA protein

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor gamma

multiple interactions

oleoyl-coenzyme A binds to and results in increased activity of PPARG protein

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

palmitoyl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-CoA oxidase 1

increases metabolic processing
multiple interactions

ACOX1 protein results in increased metabolism of Palmitoyl Coenzyme A
[ACOX1 protein results in increased metabolism of Palmitoyl Coenzyme A] which results in increased chemical synthesis of Hydrogen Peroxide; benz(a)anthracene promotes the reaction [[ACOX1 protein results in increased metabolism of Palmitoyl Coenzyme A] which results in increased chemical synthesis of Hydrogen Peroxide]; Dehydroepiandrosterone promotes the reaction [[ACOX1 protein results in increased metabolism of Palmitoyl Coenzyme A] which results in increased chemical synthesis of Hydrogen Peroxide]; Tetrachlorodibenzodioxin promotes the reaction [[ACOX1 protein results in increased metabolism of Palmitoyl Coenzyme A] which results in increased chemical synthesis of Hydrogen Peroxide]

NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232

G

carboxylesterase 1D

increases hydrolysis

CES1 protein results in increased hydrolysis of Palmitoyl Coenzyme A

NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035

G

carnitine palmitoyltransferase 1A

multiple interactions

valproyl-coenzyme A inhibits the reaction [CPT1A protein results in increased metabolism of Palmitoyl Coenzyme A]

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

diacylglycerol O-acyltransferase 1

multiple interactions

DGAT1 protein results in increased metabolism of [Palmitoyl Coenzyme A co-treated with Vitamin A]

NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299

G

glutathione S-transferase alpha 1

multiple interactions

Palmitoyl Coenzyme A binds to and results in decreased activity of GSTA1 protein

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

hepatocyte nuclear factor 4, alpha

decreases expression

Palmitoyl Coenzyme A results in decreased expression of HNF4A mRNA; Palmitoyl Coenzyme A results in decreased expression of HNF4A protein

NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320

G

peroxisome proliferator activated receptor alpha

multiple interactions

Palmitoyl Coenzyme A binds to and results in increased activity of PPARA protein
Acetylglucosamine inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Atorvastatin promotes the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Atropine inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Budesonide inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Enalapril inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Fenofibrate promotes the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; gamma-Aminobutyric Acid inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; gedunin inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]; Pravastatin promotes the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Pyrazinamide inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Saccharin inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; salicylamide inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Tolazoline inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Tolmetin inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]

PMID:11139385 PMID:18812576

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor gamma

multiple interactions

Palmitoyl Coenzyme A binds to and results in increased activity of PPARG protein

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

sex hormone binding globulin

decreases expression

Palmitoyl Coenzyme A results in decreased expression of SHBG mRNA; Palmitoyl Coenzyme A results in decreased expression of SHBG protein

NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057

spironolactone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions
decreases activity

Spironolactone inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Spironolactone results in decreased activity of ABCB11 protein

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 1A

increases expression
multiple interactions

Spironolactone results in increased expression of ABCB1 mRNA; Spironolactone results in increased expression of ABCB1 protein
Ketoconazole inhibits the reaction [Spironolactone results in increased expression of ABCB1 protein]; NR1I2 affects the reaction [Spironolactone results in increased expression of ABCB1 protein]

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 2

multiple interactions
increases expression

[Ethinyl Estradiol co-treated with Spironolactone] results in increased expression of ABCC2 protein; [Spironolactone results in increased expression of ABCC2 protein] which results in increased transport of S-(2,4-dinitrophenyl)glutathione; Ketoconazole inhibits the reaction [Spironolactone results in increased expression of ABCC2 mRNA]
Spironolactone results in increased expression of ABCC2 mRNA; Spironolactone results in increased expression of ABCC2 protein

PMID:15652244 PMID:17686906 PMID:19766108

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

multiple interactions
increases expression

[Spironolactone binds to NR1I2 protein] which results in increased expression of ABCC3 mRNA
Spironolactone results in increased expression of ABCC3 mRNA
[Ethinyl Estradiol co-treated with Spironolactone] results in increased expression of ABCC3 protein

PMID:15833929 PMID:17686906

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily G member 5

decreases expression

Spironolactone results in decreased expression of ABCG5 mRNA

NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563

G

ATP binding cassette subfamily G member 8

decreases expression

Spironolactone results in decreased expression of ABCG8 mRNA

NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912

G

angiotensin I converting enzyme

multiple interactions
decreases expression
affects expression

Spironolactone inhibits the reaction [Aldosterone results in increased activity of ACE protein]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]
Spironolactone results in decreased expression of ACE protein
Spironolactone affects the expression of ACE protein

PMID:15932931 PMID:18586661 PMID:30734886

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

angiotensin converting enzyme 2

increases expression
affects expression

Spironolactone results in increased expression of ACE2 protein
Spironolactone affects the expression of ACE2 protein

PMID:18586661 PMID:30734886

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

actin alpha 2, smooth muscle

multiple interactions

Spironolactone inhibits the reaction [Aldosterone results in increased expression of ACTA2 protein]

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

adiponectin, C1Q and collagen domain containing

multiple interactions

Spironolactone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein]
Spironolactone inhibits the reaction [Letrozole results in decreased expression of ADIPOQ protein]

PMID:29782964 PMID:33359182

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

angiotensinogen

decreases expression
increases expression
multiple interactions

Spironolactone results in decreased expression of AGT protein modified form
Spironolactone results in increased expression of AGT protein modified form
Dactinomycin promotes the reaction [Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]]; Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]

PMID:7357812 PMID:9595286 PMID:19114643 PMID:23288202

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 1a

decreases expression

Spironolactone results in decreased expression of AGTR1 protein

PMID:18586661 PMID:19114643

NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946

G

angiotensin II receptor, type 2

increases expression

Spironolactone results in increased expression of AGTR2 protein

NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057

G

aryl hydrocarbon receptor

increases expression

Spironolactone results in increased expression of AHR mRNA

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

aldehyde dehydrogenase 1 family, member A1

increases expression

Spironolactone results in increased expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 1 family, member B1

increases expression

Spironolactone results in increased expression of ALDH1B1 mRNA

NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378

G

aldehyde dehydrogenase 4 family, member A1

increases expression

Spironolactone results in increased expression of ALDH4A1 mRNA

NCBI chr 5:151,880,002...151,905,491
Ensembl chr 5:151,830,701...151,925,345

G

aldehyde dehydrogenase 8 family, member A1

increases expression

Spironolactone results in increased expression of ALDH8A1 mRNA

NCBI chr 1:16,183,940...16,203,385
Ensembl chr 1:16,183,940...16,203,385

G

alkaline phosphatase, biomineralization associated

multiple interactions

Spironolactone inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

aquaporin 2

multiple interactions

[Spironolactone co-treated with Lithium] affects the expression of AQP2 protein

NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468

G

androgen receptor

affects binding
multiple interactions

Spironolactone binds to AR protein
Spironolactone inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; Spironolactone inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Spironolactone inhibits the reaction [Metribolone results in increased activity of AR protein]; Spironolactone inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein]

PMID:10053169 PMID:14565775 PMID:14751673 PMID:15589981 PMID:18324785 More...

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

BCL2-associated agonist of cell death

increases phosphorylation
decreases expression

Spironolactone results in increased phosphorylation of BAD protein
Spironolactone results in decreased expression of BAD protein

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BCL2, apoptosis regulator

increases expression

Spironolactone results in increased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

increases expression

Spironolactone results in increased expression of BCL2L1 protein

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

beclin 1

increases expression

Spironolactone results in increased expression of BECN1 protein

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

caspase 3

multiple interactions
decreases activity
increases activity

Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP3 protein]]
Spironolactone results in decreased activity of CASP3 protein
Palmitic Acid promotes the reaction [Spironolactone results in increased activity of CASP3 protein]

PMID:19114643 PMID:20609311 PMID:22700542

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

multiple interactions
increases activity

Palmitic Acid promotes the reaction [Spironolactone results in increased activity of CASP7 protein]

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

multiple interactions

Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP8 protein]]

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions

Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP9 protein]]

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

cellular communication network factor 2

multiple interactions

Spironolactone inhibits the reaction [Aldosterone results in increased expression of CCN2 protein]

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

cyclin-dependent kinase inhibitor 2A

multiple interactions

Spironolactone inhibits the reaction [Desoxycorticosterone Acetate affects the localization of CDKN2A protein]; Spironolactone inhibits the reaction [Desoxycorticosterone Acetate results in increased expression of CDKN2A mRNA]

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

carboxylesterase 2C

increases expression

Spironolactone results in increased expression of CES2C mRNA

NCBI chr 1:260,391,190...260,398,757
Ensembl chr 1:260,388,902...260,398,790

G

collagen type III alpha 1 chain

decreases expression

Spironolactone results in decreased expression of COL3A1 protein alternative form; Spironolactone results in decreased expression of COL3A1 protein modified form

PMID:9302344 PMID:11300427 PMID:15842549

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

citrate synthase

multiple interactions

[[Dexamethasone co-treated with Spironolactone] results in increased abundance of Glucocorticoids] which results in increased activity of CS protein

NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421

G

colony stimulating factor 2

multiple interactions

Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of CSF2 protein]

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

cardiotrophin 1

multiple interactions

Dactinomycin promotes the reaction [Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]]; Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]; Spironolactone inhibits the reaction [Isoproterenol results in increased expression of CTF1 mRNA]; Spironolactone inhibits the reaction [Isoproterenol results in increased expression of CTF1 protein]

NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335

G

C-X-C motif chemokine ligand 1

decreases expression

Spironolactone results in decreased expression of CXCL1 mRNA

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

cytochrome b-245 beta chain

decreases expression

Spironolactone results in decreased expression of CYBB protein

NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586

G

cytochrome P450, family 11, subfamily b, polypeptide 3

increases expression

Spironolactone results in increased expression of CYP11B2 mRNA

NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048

G

cytochrome P450, family 2, subfamily c, polypeptide 79

decreases activity

Spironolactone results in decreased activity of CYP2C8 protein

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression

Spironolactone results in increased expression of CYP3A4 mRNA

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

multiple interactions
increases expression

NR1I2 protein promotes the reaction [Spironolactone results in increased expression of CYP3A23-3A1 mRNA]

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

cytochrome P450 family 7 subfamily A member 1

decreases activity

Spironolactone results in decreased activity of CYP7A1 protein

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

ETS proto-oncogene 1, transcription factor

increases expression

Spironolactone results in increased expression of ETS1 protein

NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010

G

fatty acid binding protein 4

multiple interactions

Spironolactone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein]

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

follicle stimulating hormone subunit beta

multiple interactions

Spironolactone inhibits the reaction [Letrozole results in decreased secretion of FSHB protein]

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

growth arrest specific 6

multiple interactions
affects expression

Spironolactone inhibits the reaction [Aldosterone results in increased expression of GAS6 protein]
Spironolactone affects the expression of GAS6 protein

NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions

Spironolactone inhibits the reaction [Aldosterone results in increased expression of GCLC protein]

PMID:24512358 PMID:25204689

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

gamma-glutamyltransferase 1

multiple interactions

Spironolactone inhibits the reaction [Letrozole results in increased activity of GGT1 protein]

NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442

G

growth regulating estrogen receptor binding 1

multiple interactions
increases expression

Fulvestrant inhibits the reaction [Spironolactone results in increased expression of GREB1 mRNA]

NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633

G

glutathione-disulfide reductase

multiple interactions

Spironolactone inhibits the reaction [Letrozole results in decreased expression of GSR protein]

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase mu 1

increases expression

Spironolactone results in increased expression of GSTM1 mRNA; Spironolactone results in increased expression of GSTM5 mRNA

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase mu 2

increases expression

Spironolactone results in increased expression of GSTM2 mRNA

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase, mu 5

increases expression

Spironolactone results in increased expression of GSTM3 mRNA

NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553

G

hypoxia inducible factor 1 subunit alpha

increases expression

Spironolactone results in increased expression of HIF1A protein

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

heme oxygenase 1

increases expression

Spironolactone results in increased expression of HMOX1 mRNA; Spironolactone results in increased expression of HMOX1 protein

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heparanase

multiple interactions

[Spironolactone co-treated with Lisinopril] inhibits the reaction [Doxorubicin results in increased expression of HPSE protein]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of HPSE mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of HPSE protein]; Spironolactone inhibits the reaction [Doxorubicin results in increased expression of HPSE protein]

NCBI chr14:8,896,593...8,937,011
Ensembl chr14:8,896,593...8,937,010

G

hydroxysteroid 11-beta dehydrogenase 1

multiple interactions

Spironolactone inhibits the reaction [Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]]

NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687

G

hydroxysteroid 11-beta dehydrogenase 2

decreases expression

Spironolactone results in decreased expression of HSD11B2 mRNA

NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899

G

interferon gamma

multiple interactions

Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IFNG protein]

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 10

multiple interactions

Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL10 protein]

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 18

multiple interactions

Spironolactone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 beta

multiple interactions
increases expression

[Spironolactone co-treated with Lipopolysaccharides] results in increased expression of IL1B protein
Spironolactone results in increased expression of IL1B protein

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

multiple interactions

Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL2 protein]

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 6

multiple interactions

Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL6 protein]
Spironolactone inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; Spironolactone inhibits the reaction [Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]]
Spironolactone inhibits the reaction [Letrozole results in increased expression of IL6 protein]; Spironolactone inhibits the reaction [Letrozole results in increased secretion of IL6 protein]

PMID:17051331 PMID:30993381 PMID:33359182 PMID:37328115

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 1

multiple interactions

Spironolactone inhibits the reaction [Letrozole results in increased expression of INS1 protein]

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

insulin 2

multiple interactions

Spironolactone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein]; Spironolactone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein]

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

Janus kinase 2

multiple interactions

Spironolactone inhibits the reaction [Aldosterone results in increased phosphorylation of JAK2 protein]

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

lactate dehydrogenase A

multiple interactions

Spironolactone inhibits the reaction [Letrozole results in increased activity of LDHA protein]

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

luteinizing hormone subunit beta

multiple interactions

Spironolactone inhibits the reaction [Letrozole results in increased secretion of LHB protein]

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

microtubule-associated protein 1 light chain 3 beta

increases expression

Spironolactone results in increased expression of MAP1LC3B protein

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690

G

microsomal glutathione S-transferase 1

increases expression

Spironolactone results in increased expression of MGST1 mRNA

NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892

G

myeloperoxidase

multiple interactions

Spironolactone inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

metallothionein 1

multiple interactions

Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased expression of MT1A protein]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of MT1A mRNA]

PMID:17616752 PMID:19333130

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049

G

metal-regulatory transcription factor 1

multiple interactions

Spironolactone inhibits the reaction [Aldosterone results in increased expression of MTF1 mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of MTF1 protein]

NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136

G

MYB proto-oncogene like 1

multiple interactions
increases expression

Fulvestrant inhibits the reaction [Spironolactone results in increased expression of MYBL1 mRNA]

NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183

G

neutrophil cytosolic factor 2

decreases expression

Spironolactone results in decreased expression of NCF2 protein

NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277

G

NFE2 like bZIP transcription factor 2

multiple interactions

Spironolactone inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NLR family, pyrin domain containing 3

multiple interactions

Spironolactone inhibits the reaction [Letrozole results in increased expression of NLRP3 protein]

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

NPHS1 adhesion molecule, nephrin

multiple interactions

Spironolactone inhibits reaction [sodium chloride decreases expression of Nphs1 mRNA in hyperaldosteronic kidney]

RGD

NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078

G

NPHS2 stomatin family member, podocin

increases expression

Spironolactone results in increased expression of NPHS2 protein

NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313

G

natriuretic peptide A

decreases expression
multiple interactions

Spironolactone results in decreased expression of NPPA protein; Spironolactone results in decreased expression of NPPA protein modified form
Spironolactone inhibits the reaction [Aldosterone results in increased expression of NPPA mRNA]; Spironolactone inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]; Spironolactone inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]

PMID:9595286 PMID:11300427 PMID:19966502 PMID:23288202

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

natriuretic peptide B

decreases expression
multiple interactions

Spironolactone results in decreased expression of NPPB protein
[carvedilol co-treated with temocapril hydrochloride co-treated with Spironolactone co-treated with Aspirin] affects the expression of NPPB protein

PMID:11300427 PMID:21378469

NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions
increases expression

[Spironolactone binds to NR1I2 protein] which results in increased expression of ABCC3 mRNA; Spironolactone binds to and results in increased activity of NR1I2 protein
NR1I2 affects the reaction [Spironolactone results in increased expression of ABCB1 protein]; Spironolactone binds to and results in increased activity of NR1I2 protein
Spironolactone results in increased expression of NR1I2 mRNA
NR1I2 protein promotes the reaction [Spironolactone results in increased expression of CYP3A23-3A1 mRNA]

PMID:11752103 PMID:15833929 PMID:15919853 PMID:16054614 PMID:17627975 More...

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 3, group C, member 2

decreases expression
multiple interactions
increases activity

Spironolactone results in decreased expression of NR3C2 mRNA; Spironolactone results in decreased expression of NR3C2 protein
Spironolactone inhibits the reaction [Phenylephrine results in increased localization of NR3C2 protein]
Spironolactone results in increased activity of NR3C2 protein
Spironolactone inhibits the reaction [Aldosterone affects the ubiquitination of NR3C2 protein]; Spironolactone inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]

PMID:15780662 PMID:17587755 PMID:19114643 PMID:19966502 PMID:22798426 More...

NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885

G

oxidized low density lipoprotein receptor 1

multiple interactions

Spironolactone inhibits the reaction [Aldosterone results in increased expression of OLR1 mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of OLR1 protein]

NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523

G

proprotein convertase subtilisin/kexin type 9

multiple interactions

Spironolactone inhibits the reaction [Letrozole results in increased expression of and results in increased secretion of PCSK9 protein]

NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688

G

plasminogen activator, tissue type

increases expression

Spironolactone results in increased expression of PLAT protein

NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223

G

proopiomelanocortin

multiple interactions

Spironolactone inhibits the reaction [POMC protein modified form results in decreased abundance of Potassium]; Spironolactone inhibits the reaction [POMC protein modified form results in increased abundance of Sodium]

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

paraoxonase 3

increases hydrolysis

PON3 protein results in increased hydrolysis of Spironolactone

NCBI chr 4:33,356,983...33,383,681
Ensembl chr 4:33,349,168...33,383,855

G

peroxisome proliferator activated receptor alpha

increases expression

Spironolactone results in increased expression of PPARA mRNA

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

prolactin

multiple interactions

Spironolactone inhibits the reaction [Letrozole results in increased expression of PRL protein]

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

Rac family small GTPase 1

decreases expression

Spironolactone results in decreased expression of RAC1 protein

NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251

G

renin

multiple interactions
decreases response to substance
increases expression

[Clonidine co-treated with Spironolactone] results in decreased expression of REN protein
REN protein results in decreased susceptibility to Spironolactone
Spironolactone results in increased expression of REN protein

PMID:6998872 PMID:9595286 PMID:12014310 PMID:20016520

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

G

serpin family E member 1

decreases expression

Spironolactone results in decreased expression of SERPINE1 protein

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

serum/glucocorticoid regulated kinase 1

multiple interactions
increases expression

Spironolactone inhibits the reaction [Aldosterone results in increased expression of SGK1 mRNA]
Spironolactone results in increased expression of SGK1 mRNA
Fulvestrant inhibits the reaction [Spironolactone results in increased expression of SGK1 mRNA]

PMID:19429930 PMID:33405908

NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283

G

sex hormone binding globulin

multiple interactions

Spironolactone inhibits the reaction [Letrozole results in decreased secretion of SHBG protein]

NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057

G

solute carrier family 12 member 2

multiple interactions

Spironolactone inhibits the reaction [Aldosterone results in increased activity of SLC12A2 protein]

NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440

G

solute carrier family 22 member 1

multiple interactions

Spironolactone inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678

G

solute carrier family 22 member 2

multiple interactions

Spironolactone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 22 member 3

multiple interactions

Spironolactone inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612

G

solute carrier family 22 member 4

multiple interactions

Spironolactone inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]

NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720

G

solute carrier family 22 member 5

multiple interactions

Spironolactone inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]

NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309

G

solute carrier family 30 member 1

multiple interactions

Spironolactone inhibits the reaction [Aldosterone results in increased expression of SLC30A1 mRNA]

NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910

G

solute carrier family 39 member 1

multiple interactions

Spironolactone inhibits the reaction [Aldosterone results in increased expression of SLC39A1 mRNA]

NCBI chr 2:175,703,413...175,709,063
Ensembl chr 2:175,703,441...175,709,058

G

solute carrier organic anion transporter family, member 1a4

increases expression

Spironolactone results in increased expression of SLCO1A4 mRNA

NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573

G

solute carrier organic anion transporter family member 1B2

decreases expression

Spironolactone results in decreased expression of SLCO1B2 mRNA

NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981

G

solute carrier organic anion transporter family, member 2a1

decreases expression

Spironolactone results in decreased expression of SLCO2A1 mRNA

NCBI chr 8:103,588,916...103,672,546
Ensembl chr 8:103,588,916...103,672,546

G

solute carrier organic anion transporter family, member 2b1

decreases expression

Spironolactone results in decreased expression of SLCO2B1 mRNA

NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353

G

superoxide dismutase 1

multiple interactions

Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in decreased activity of SOD1 protein]; Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased activity of SOD1 protein]; Spironolactone inhibits the reaction [Aldosterone results in increased activity of SOD1 protein]

PMID:17616752 PMID:19333130

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

trefoil factor 1

increases expression

Spironolactone results in increased expression of TFF1 mRNA

NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597

G

transforming growth factor, beta 1

decreases expression
multiple interactions

Spironolactone results in decreased expression of TGFB1 protein
Spironolactone inhibits the reaction [Aldosterone results in increased expression of TGFB1 mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased secretion of TGFB1 protein]

PMID:15130897 PMID:16928621 PMID:25204689

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tenascin C

multiple interactions

Spironolactone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TNC mRNA]

NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624

G

tumor necrosis factor

multiple interactions

Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of TNF protein]; Spironolactone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Spironolactone inhibits the reaction [Letrozole results in increased expression of TNF protein]

PMID:16528473 PMID:17051331 PMID:33359182

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

UDP glucuronosyltransferase family 1 member A1

increases expression
increases activity

Spironolactone results in increased expression of UGT1A1 mRNA
Spironolactone results in increased activity of UGT1A1 protein

PMID:12818378 PMID:19144771

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases expression

Spironolactone results in increased expression of UGT1A2 mRNA

NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glycosyltransferase 1 family, polypeptide A3

increases expression
increases activity

Spironolactone results in increased expression of UGT1A5 mRNA
Spironolactone results in increased activity of UGT1A5 protein

NCBI chr 9:88,780,328...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A5

increases expression

Spironolactone results in increased expression of UGT1A5 mRNA

NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A6

increases expression

Spironolactone results in increased expression of UGT1A6 mRNA

NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 1 family, polypeptide A7C

increases expression
multiple interactions
increases activity

Spironolactone results in increased expression of UGT1A7 protein
[Ethinyl Estradiol co-treated with Spironolactone] results in increased activity of UGT1A7 protein; [Ethinyl Estradiol co-treated with Spironolactone] results in increased expression of UGT1A7 protein
Spironolactone results in increased activity of UGT1A7 protein

NCBI chr 9:88,739,577...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

increases expression

Spironolactone results in increased expression of UGT1A9 mRNA

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

vascular endothelial growth factor A

increases expression

Spironolactone results in increased expression of VEGFA protein

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

WT1 transcription factor

increases expression

Spironolactone results in increased expression of WT1 protein

NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643

stearoyl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glutathione S-transferase alpha 1

multiple interactions

stearoyl-coenzyme A binds to and results in decreased activity of GSTA1 protein

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

peroxisome proliferator activated receptor alpha

multiple interactions

stearoyl-coenzyme A binds to and results in increased activity of PPARA protein

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor gamma

multiple interactions

stearoyl-coenzyme A binds to and results in increased activity of PPARG protein

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

succinyl-CoA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-CoA thioesterase 4

affects hydrolysis

ACOT4 protein affects the hydrolysis of succinyl-coenzyme A

NCBI chr 6:103,668,699...103,674,037
Ensembl chr 6:103,668,753...103,673,917

thiodicarb

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

decreases activity

thiodicarb results in decreased activity of ACHE protein

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19932
chemical entity	19930
group	19888
inorganic group	19460
oxo group	18945
organic oxo compound	18945
carbonyl compound	18945
thioester	194
(+)-2,3-dienoyl fatty acyl thioester	0
2-(3,4-dimethylphenoxy)ethanethioic acid S-(4-methylphenyl) ester	0
Allyl thiohexanoate	0
Arachidonoyl-1-thio-Glycerol	0
Cuniculene 6B	0
Dithiopyr	5
Me-YTM-T	0
Methylthiomethyl 2-methylbutanethiolate	0
N-acetyl-S-glyceroyl-L-cysteine	0
O-(S-acylpantetheine-4'-phosphoryl)serine +	0
S-(2-acetamidoethyl) (2S,3R)-3-hydroxy-2-methylpentanethioate	0
S-(3-hydroxypropyl)-thioacetate	0
S-(long-chain fatty acyl)-L-cysteine +	0
S-Methyl 4-methylpentanethioate	0
S-Methyl hexanethioate	0
S-[5-(trifluoromethyl)-4H-1,2,4-triazol-3-yl] 5-(phenylethynyl)furan-2-carbothioate	0
S-acetylcysteamine	0
S-acyl-4'-phosphopantetheine +	0
S-acylglutathione +	0
S-anthraniloyl-L-cysteine +	0
S-glycyl-L-cysteine	0
S-methyl 3-O-phosphonato-1-thio-D-glycerate(2-)	0
S-methyl 3-phospho-1-thio-D-glycerate	0
S-methyl D-thioglycerate	0
S-methyl thioacetate +	19
S-octanoyl-L-cysteine	0
S-propyl hexanethioate	0
SID 26681509	0
SNAC	0
YTM-T	0
acetyl-beta-methylthiocholine iodide	0
acibenzolar-S-methyl	0
acyl-CoA +	29
benfotiamine	15
calicheamicin +	0
fenpyrazamine	0
fluticasone +	41
fluticasone furoate +	0
fluticasone propionate	0
lehualide H	0
spironolactone	123
thioacetate ester +	0
thiolactone +	0
tixocortol pivalate	0
zofenopril	0
Path 2
Term	Annotations
CHEBI ontology	19932
subatomic particle	19930
composite particle	19930
hadron	19930
baryon	19930
nucleon	19930
atomic nucleus	19930
atom	19930
main group element atom	19876
p-block element atom	19876
carbon group element atom	19816
carbon atom	19812
organic molecular entity	19812
heteroorganic entity	19559
organochalcogen compound	19317
organooxygen compound	19231
ester	17490
thiocarboxylic ester	202
thioester	194
(+)-2,3-dienoyl fatty acyl thioester	0
2-(3,4-dimethylphenoxy)ethanethioic acid S-(4-methylphenyl) ester	0
Allyl thiohexanoate	0
Arachidonoyl-1-thio-Glycerol	0
Cuniculene 6B	0
Dithiopyr	5
Me-YTM-T	0
Methylthiomethyl 2-methylbutanethiolate	0
N-acetyl-S-glyceroyl-L-cysteine	0
O-(S-acylpantetheine-4'-phosphoryl)serine +	0
S-(2-acetamidoethyl) (2S,3R)-3-hydroxy-2-methylpentanethioate	0
S-(3-hydroxypropyl)-thioacetate	0
S-(long-chain fatty acyl)-L-cysteine +	0
S-Methyl 4-methylpentanethioate	0
S-Methyl hexanethioate	0
S-[5-(trifluoromethyl)-4H-1,2,4-triazol-3-yl] 5-(phenylethynyl)furan-2-carbothioate	0
S-acetylcysteamine	0
S-acyl-4'-phosphopantetheine +	0
S-acylglutathione +	0
S-anthraniloyl-L-cysteine +	0
S-glycyl-L-cysteine	0
S-methyl 3-O-phosphonato-1-thio-D-glycerate(2-)	0
S-methyl 3-phospho-1-thio-D-glycerate	0
S-methyl D-thioglycerate	0
S-methyl thioacetate +	19
S-octanoyl-L-cysteine	0
S-propyl hexanethioate	0
SID 26681509	0
SNAC	0
YTM-T	0
acetyl-beta-methylthiocholine iodide	0
acibenzolar-S-methyl	0
acyl-CoA +	29
benfotiamine	15
calicheamicin +	0
fenpyrazamine	0
fluticasone +	41
fluticasone furoate +	0
fluticasone propionate	0
lehualide H	0
spironolactone	123
thioacetate ester +	0
thiolactone +	0
tixocortol pivalate	0
zofenopril	0

paths to the root