CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: phenanthridines
Accession: CHEBI:51245
browse the term
Definition: Any dibenzopyridine based on the skeleton of phenanthridine and its substituted derivatives thereof.
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Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
Ethidium inhibits the reaction [Estradiol results in increased expression of BCL2 mRNA]
CTD
PMID:15897899
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Ccnd1
cyclin D1
multiple interactions
ISO
Ethidium inhibits the reaction [Estradiol results in increased expression of CCND1 mRNA]
CTD
PMID:15897899
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Ccne1
cyclin E1
multiple interactions
ISO
Ethidium inhibits the reaction [Estradiol results in increased expression of CCNE1 mRNA]
CTD
PMID:15897899
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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Ccne2
cyclin E2
multiple interactions
ISO
Ethidium inhibits the reaction [Estradiol results in increased expression of CCNE2 mRNA]
CTD
PMID:15897899
NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
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Cd59
CD59 molecule
increases mutagenesis
ISO
Ethidium results in increased mutagenesis of CD59 protein
CTD
PMID:17045307
NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847
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Gja1
gap junction protein, alpha 1
increases uptake
EXP
GJA1 protein results in increased uptake of Ethidium
CTD
PMID:26926986
NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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Il1a
interleukin 1 alpha
multiple interactions
ISO
Ethidium inhibits the reaction [sodium arsenate results in increased expression of IL1A protein]; Ethidium inhibits the reaction [tributyltin results in increased expression of IL1A protein]
CTD
PMID:8875956 PMID:10571731
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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Mt-co1
mitochondrially encoded cytochrome c oxidase I
decreases expression
ISO
Ethidium results in decreased expression of COX1 protein
CTD
PMID:18823003
NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
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Mt-co2
mitochondrially encoded cytochrome c oxidase II
decreases expression
ISO
Ethidium results in decreased expression of COX2 mRNA
CTD
PMID:22712077
NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
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Mt-cyb
mitochondrially encoded cytochrome b
decreases expression
ISO
Ethidium results in decreased expression of CYTB mRNA
CTD
PMID:22712077
NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278
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Mt-nd1
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1
decreases expression
ISO
Ethidium results in decreased expression of ND1 mRNA
CTD
PMID:22712077
NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694
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Mt-nd4
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4
decreases expression
ISO
Ethidium results in decreased expression of ND4 mRNA
CTD
PMID:22712077
NCBI chr MT:10,160...11,537
Ensembl chr MT:10,160...11,537
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Nrf1
nuclear respiratory factor 1
increases expression
ISO
Ethidium results in increased expression of NRF1 mRNA
CTD
PMID:22712077
NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328
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P2rx7
purinergic receptor P2X 7
decreases transport increases transport
ISO
P2RX7 gene polymorphism results in decreased transport of Ethidium P2RX7 protein results in increased transport of Ethidium
CTD
PMID:16263709
NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619
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Slc22a1
solute carrier family 22 member 1
multiple interactions increases uptake affects uptake
ISO
1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]; Cimetidine inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]; Quinine inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]; Tetraethylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium] SLC22A1 protein affects the uptake of Ethidium
CTD
PMID:19357179
NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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Slc22a2
solute carrier family 22 member 2
affects uptake multiple interactions increases uptake
ISO
SLC22A2 protein affects the uptake of Ethidium 1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]; Cimetidine inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]; Ethidium inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Quinine inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]; Tetraethylammonium inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]
CTD
PMID:19357179
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Slc22a3
solute carrier family 22 member 3
increases uptake multiple interactions
ISO
SLC22A3 protein results in increased uptake of Ethidium 1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]; Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]; Quinine inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]; Tetraethylammonium inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]
CTD
PMID:19357179
NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
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Tfam
transcription factor A, mitochondrial
increases expression
ISO
Ethidium results in increased expression of TFAM mRNA
CTD
PMID:22712077
NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
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Il6
interleukin 6
multiple interactions
ISO
narciclasine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
CTD
PMID:30738987
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Mapk8
mitogen-activated protein kinase 8
multiple interactions
ISO
narciclasine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]
CTD
PMID:30738987
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Nfkbia
NFKB inhibitor alpha
multiple interactions
ISO
narciclasine inhibits the reaction [Lipopolysaccharides results in increased degradation of and results in increased phosphorylation of NFKBIA protein]
CTD
PMID:30738987
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Nos2
nitric oxide synthase 2
multiple interactions
ISO
narciclasine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]
CTD
PMID:30738987
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
narciclasine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; narciclasine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
CTD
PMID:30738987
NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
narciclasine inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased phosphorylation of RELA protein]
CTD
PMID:30738987
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Tnf
tumor necrosis factor
multiple interactions
ISO
narciclasine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
CTD
PMID:30738987
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Top1
DNA topoisomerase I
decreases expression
ISO
nitidine results in decreased expression of TOP1 mRNA; nitidine results in decreased expression of TOP1 protein
CTD
PMID:30132517
NCBI chr 3:149,293,658...149,375,405
Ensembl chr 3:149,293,403...149,376,623
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Top2a
DNA topoisomerase II alpha
decreases expression
ISO
nitidine results in decreased expression of TOP2A mRNA; nitidine results in decreased expression of TOP2A protein
CTD
PMID:30132517
NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874
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Aifm1
apoptosis inducing factor, mitochondria associated 1
multiple interactions
ISO
phenanthridone inhibits the reaction [Methylnitronitrosoguanidine results in increased localization of AIFM1 protein]
CTD
PMID:15589979
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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Casp7
caspase 7
multiple interactions
ISO
[eprenetapopt co-treated with phenanthridone] results in increased cleavage of CASP7 protein
CTD
PMID:29416738
NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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Casp9
caspase 9
multiple interactions
ISO
[eprenetapopt co-treated with phenanthridone] results in increased cleavage of CASP9 protein
CTD
PMID:29416738
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Ccl3
C-C motif chemokine ligand 3
multiple interactions
ISO
phenanthridone analog inhibits the reaction [endotoxin, Escherichia coli results in increased expression of CCL3 protein]
CTD
PMID:12006805
NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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Cd83
CD83 molecule
decreases expression
ISO
phenanthridone results in decreased expression of CD83 mRNA; phenanthridone results in decreased expression of CD83 protein
CTD
PMID:17579050
NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083
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Cd86
CD86 molecule
decreases expression
ISO
phenanthridone results in decreased expression of CD86 mRNA; phenanthridone results in decreased expression of CD86 protein
CTD
PMID:17579050
NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
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Cxcl2
C-X-C motif chemokine ligand 2
multiple interactions
ISO
phenanthridone analog inhibits the reaction [endotoxin, Escherichia coli results in increased expression of CXCL2 protein]
CTD
PMID:12006805
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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H2ax
H2A.X variant histone
increases expression multiple interactions
ISO
phenanthridone results in increased expression of H2AX protein modified form Acetylcysteine inhibits the reaction [phenanthridone results in increased expression of H2AX protein modified form]; TXNRD1 protein inhibits the reaction [phenanthridone results in increased expression of H2AX protein modified form]
CTD
PMID:29416738
NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
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Ifng
interferon gamma
multiple interactions decreases expression
EXP
phenanthridone inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA] phenanthridone results in decreased expression of IFNG mRNA
CTD
PMID:12411406
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il10
interleukin 10
multiple interactions
ISO
phenanthridone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]
CTD
PMID:17579050
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il12b
interleukin 12B
multiple interactions
ISO
phenanthridone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]
CTD
PMID:17579050
NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
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Il1b
interleukin 1 beta
decreases expression
EXP
phenanthridone results in decreased expression of IL1B mRNA
CTD
PMID:12411406
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il2
interleukin 2
decreases expression multiple interactions
EXP
phenanthridone results in decreased expression of IL2 mRNA phenanthridone inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2 mRNA]
CTD
PMID:12411406
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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Kif18a
kinesin family member 18A
increases metabolic processing
ISO
phenanthridone results in increased metabolism of KIF18A protein
CTD
PMID:28209915
NCBI chr 3:95,764,388...95,824,756
Ensembl chr 3:95,764,388...95,824,582
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Kifc1
kinesin family member C1
increases metabolic processing
ISO
phenanthridone results in increased metabolism of KIFC1 protein
CTD
PMID:28209915
NCBI chr20:4,998,832...5,017,107
Ensembl chr20:4,999,047...5,017,105
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Nos2
nitric oxide synthase 2
decreases expression
EXP
phenanthridone results in decreased expression of NOS2 mRNA
CTD
PMID:12411406
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Parp1
poly (ADP-ribose) polymerase 1
decreases activity multiple interactions
EXP ISO
phenanthridone results in decreased activity of PARP1 protein [eprenetapopt co-treated with phenanthridone] results in increased cleavage of PARP1 protein
CTD
PMID:12411406 PMID:29416738
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Ptgs2
prostaglandin-endoperoxide synthase 2
decreases expression
EXP
phenanthridone results in decreased expression of PTGS2 mRNA
CTD
PMID:12411406
NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
G
Tnf
tumor necrosis factor
multiple interactions decreases expression
EXP ISO
phenanthridone inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of TNF mRNA] phenanthridone results in decreased expression of TNF mRNA phenanthridone analog inhibits the reaction [endotoxin, Escherichia coli results in increased expression of TNF protein]
CTD
PMID:12006805 PMID:12411406
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Txnrd1
thioredoxin reductase 1
multiple interactions decreases expression
ISO
TXNRD1 protein inhibits the reaction [phenanthridone results in increased expression of H2AX protein modified form] phenanthridone results in decreased expression of TXNRD1 mRNA; phenanthridone results in decreased expression of TXNRD1 protein
CTD
PMID:29416738
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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Ache
acetylcholinesterase
multiple interactions decreases activity
ISO
Propidium binds to and results in decreased activity of ACHE protein; Propidium promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; Propidium promotes the reaction [haloxon results in increased phosphorylation of ACHE protein]; Propidium promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein] Propidium results in decreased activity of ACHE protein
CTD
PMID:10421444 PMID:25522658 PMID:27238725
NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Bche
butyrylcholinesterase
decreases activity
ISO
Propidium results in decreased activity of BCHE protein
CTD
PMID:31173753
NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
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Ccl2
C-C motif chemokine ligand 2
decreases expression
ISO
Propidium results in decreased expression of CCL2 protein
CTD
PMID:20116850
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccl3
C-C motif chemokine ligand 3
decreases expression
ISO
Propidium results in decreased expression of CCL3 protein
CTD
PMID:20116850
NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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Ccl4
C-C motif chemokine ligand 4
decreases expression
ISO
Propidium results in decreased expression of CCL4 protein
CTD
PMID:20116850
NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
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Ccl5
C-C motif chemokine ligand 5
decreases expression
ISO
Propidium results in decreased expression of CCL5 protein
CTD
PMID:20116850
NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
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Il6r
interleukin 6 receptor
decreases expression
ISO
Propidium results in decreased expression of IL6R protein modified form
CTD
PMID:20116850
NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
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Vegfa
vascular endothelial growth factor A
decreases expression
ISO
Propidium results in decreased expression of VEGFA protein
CTD
PMID:20116850
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
20057
chemical entity
20068
atom
20056
nonmetal atom
19948
nitrogen atom
19033
nitrogen molecular entity
19047
organonitrogen compound
18831
organonitrogen heterocyclic compound
17998
dibenzopyridine
155
phenanthridines
51
(+)-2,7-Dideoxypancratistatin
0
(+)-Luguine
0
(-)-8-Demethylmaritidine
0
(1S,10R,12R)-5,6,12-Trimethoxy-9-azatetracyclo[7.5.2.01,10.02,7]hexadeca-2,4,6,13-tetraen-4-ol
0
(6aR,12bS)-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine-10,11-diol
0
1,2-Dimethoxy-13-methyl-[1,3]benzodioxolo[5,6-c]phenanthridine
0
1-Epideacetylbowdensine
0
2-O-Acetylpseudolycorine
0
2-[(2,3-dimethyl-7,8,9,10-tetrahydrophenanthridin-6-yl)thio]-N-(4-methyl-1,2,5-oxadiazol-3-yl)acetamide
0
3-Methoxy-8,9-methylenedioxy-3,4-dihydrophenanthridine
0
5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine-10,11-diol
0
5H-phenanthridine-6-thione
0
6(5h)-benzo[c]phenanthridinone, 11,12-dihydro-
0
6-(1-azepanyl)phenanthridine
0
7-Deoxypancratistatin
0
Anhydrolycorinone
0
Asiaticumine A
0
Assoanine
0
Carinatine
0
Crinasiadine
0
Crinasiatine
0
Currayangine
0
EDTA methidiumpropylamide
0
Isomurrayazoline
0
Kalbreclasine
0
LSM-3788
0
Lycoricidine
0
Narciclasine
7
Narcissidine
0
Nitidine
2
Noroxopluviine
0
Norsanguinarine
0
Oxoassoanine
0
PJ34
0
Papyramine
0
Pseudolycorine
0
Trisphaeridine
0
Vasconine
0
Zephyramine
0
ethidium +
18
paritaprevir +
0
phenanthridine +
18
phenanthridone
20
propidium +
8
Path 2
CHEBI ontology
20057
subatomic particle
20056
composite particle
20068
hadron
20056
baryon
20056
nucleon
20056
atomic nucleus
20056
atom
20056
main group element atom
19971
p-block element atom
19971
carbon group element atom
19889
carbon atom
19894
organic molecular entity
19882
organic molecule
19830
organic cyclic compound
19603
organic heterocyclic compound
18888
organic heteropolycyclic compound
18300
organic heterotricyclic compound
15608
dibenzopyridine
155
phenanthridines
51
(+)-2,7-Dideoxypancratistatin
0
(+)-Luguine
0
(-)-8-Demethylmaritidine
0
(1S,10R,12R)-5,6,12-Trimethoxy-9-azatetracyclo[7.5.2.01,10.02,7]hexadeca-2,4,6,13-tetraen-4-ol
0
(6aR,12bS)-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine-10,11-diol
0
1,2-Dimethoxy-13-methyl-[1,3]benzodioxolo[5,6-c]phenanthridine
0
1-Epideacetylbowdensine
0
2-O-Acetylpseudolycorine
0
2-[(2,3-dimethyl-7,8,9,10-tetrahydrophenanthridin-6-yl)thio]-N-(4-methyl-1,2,5-oxadiazol-3-yl)acetamide
0
3-Methoxy-8,9-methylenedioxy-3,4-dihydrophenanthridine
0
5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine-10,11-diol
0
5H-phenanthridine-6-thione
0
6(5h)-benzo[c]phenanthridinone, 11,12-dihydro-
0
6-(1-azepanyl)phenanthridine
0
7-Deoxypancratistatin
0
Anhydrolycorinone
0
Asiaticumine A
0
Assoanine
0
Carinatine
0
Crinasiadine
0
Crinasiatine
0
Currayangine
0
EDTA methidiumpropylamide
0
Isomurrayazoline
0
Kalbreclasine
0
LSM-3788
0
Lycoricidine
0
Narciclasine
7
Narcissidine
0
Nitidine
2
Noroxopluviine
0
Norsanguinarine
0
Oxoassoanine
0
PJ34
0
Papyramine
0
Pseudolycorine
0
Trisphaeridine
0
Vasconine
0
Zephyramine
0
ethidium +
18
paritaprevir +
0
phenanthridine +
18
phenanthridone
20
propidium +
8