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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
multiple interactions |
ISO EXP |
zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]]; zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]] zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]] |
CTD |
PMID:20052772 PMID:20861358 |
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NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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G |
Agt |
angiotensinogen |
multiple interactions |
ISO |
[zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [neferine inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]]; [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [neferine inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]] |
CTD |
PMID:20523338 |
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NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
EXP |
zinc protoporphyrin inhibits the reaction [olprinone results in increased activity of AKT1 protein] |
CTD |
PMID:19387321 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Alad |
aminolevulinate dehydratase |
affects abundance |
ISO |
ALAD gene SNP affects the abundance of zinc protoporphyrin |
CTD |
PMID:25963508 |
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NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
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G |
Alb |
albumin |
multiple interactions |
ISO |
ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [Peptidoglycan results in increased expression of NOS2 protein]]; ALB protein inhibits the reaction [zinc protoporphyrin results in increased expression of HMOX1 protein] zinc protoporphyrin inhibits the reaction [ALB protein results in increased expression of HMOX1 protein]; zinc protoporphyrin promotes the reaction [ALB protein results in increased expression of TIMP1 protein] |
CTD |
PMID:19376148 PMID:21163135 |
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NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
Alms1 |
ALMS1, centrosome and basal body associated protein |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of ALMS1 mRNA |
CTD |
PMID:22839698 |
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NCBI chr 4:118,125,581...118,226,005
Ensembl chr 4:118,125,607...118,226,005
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G |
Ap2a1 |
adaptor related protein complex 2 subunit alpha 1 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of AP2A1 mRNA |
CTD |
PMID:22839698 |
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NCBI chr 1:95,384,306...95,414,170
Ensembl chr 1:95,384,309...95,414,147
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G |
Ap3d1 |
adaptor related protein complex 3 subunit delta 1 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of AP3D1 mRNA |
CTD |
PMID:22839698 |
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NCBI chr 7:8,970,249...9,005,651
Ensembl chr 7:8,970,291...9,005,643
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G |
Asf1a |
anti-silencing function 1A histone chaperone |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of ASF1A mRNA |
CTD |
PMID:22839698 |
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NCBI chr20:32,893,962...32,908,808
Ensembl chr20:32,893,573...32,908,808
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO EXP |
zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]]; zinc protoporphyrin inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of BAX protein]] zinc protoporphyrin inhibits the reaction [Cisplatin results in increased expression of BAX protein] zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]] |
CTD |
PMID:22763982 PMID:27523796 PMID:27815112 PMID:32621855 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO EXP |
zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; zinc protoporphyrin inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]] zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]] |
CTD |
PMID:22763982 PMID:27523796 PMID:32621855 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions increases expression |
EXP ISO |
zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of BCL2L1 protein] zinc protoporphyrin results in increased expression of BCL2L1 protein |
CTD |
PMID:20357190 PMID:27829220 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Bcl2l11 |
Bcl2-like 11 |
increases expression |
ISO |
zinc protoporphyrin results in increased expression of BCL2L11 protein |
CTD |
PMID:27829220 |
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NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
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G |
Birc3 |
baculoviral IAP repeat-containing 3 |
multiple interactions |
ISO |
zinc protoporphyrin analog inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of BIRC3 protein] |
CTD |
PMID:18508827 |
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NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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G |
Calca |
calcitonin-related polypeptide alpha |
multiple interactions |
EXP |
zinc protoporphyrin inhibits the reaction [monophosphoryl lipid A results in increased expression of CALCA mRNA] |
CTD |
PMID:11738242 |
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NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
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G |
Cand1 |
cullin-associated and neddylation-dissociated 1 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of CAND1 mRNA |
CTD |
PMID:22839698 |
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NCBI chr 7:54,681,114...54,719,002
Ensembl chr 7:54,680,900...54,718,993
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G |
Casp1 |
caspase 1 |
multiple interactions |
ISO |
zinc protoporphyrin inhibits the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased cleavage of CASP1 protein]] |
CTD |
PMID:36858639 |
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NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Casp3 |
caspase 3 |
multiple interactions decreases activity increases cleavage |
ISO EXP |
zinc protoporphyrin inhibits the reaction [[Glucose deficiency co-treated with Simvastatin] results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [Resveratrol inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]]; zinc protoporphyrin inhibits the reaction [sesamol inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]]; zinc protoporphyrin promotes the reaction [T-2 Toxin results in increased activity of CASP3 protein] zinc protoporphyrin results in decreased activity of CASP3 protein zinc protoporphyrin inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in decreased expression of CASP3 protein]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of CASP3 mRNA]]; zinc protoporphyrin promotes the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased cleavage of CASP3 protein]; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased cleavage of CASP3 protein] zinc protoporphyrin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased activity of CASP3 protein]]; zinc protoporphyrin inhibits the reaction [FASLG protein results in increased activity of CASP3 protein]; zinc protoporphyrin inhibits the reaction [FASLG protein results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]]; zinc protoporphyrin promotes the reaction [arsenic trioxide results in increased activity of CASP3 protein]; zinc protoporphyrin promotes the reaction [quinocetone results in increased activity of CASP3 protein] zinc protoporphyrin results in increased cleavage of CASP3 protein |
CTD |
PMID:16051694 PMID:17928392 PMID:20357190 PMID:21295052 PMID:22763982 PMID:25003661 PMID:26747958 PMID:27375190 PMID:27815112 PMID:28025122 PMID:29432840 PMID:30261164 PMID:32621855 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
multiple interactions |
ISO |
zinc protoporphyrin inhibits the reaction [FASLG protein results in increased activity of CASP8 protein] |
CTD |
PMID:16051694 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased activity of CASP9 protein]]; zinc protoporphyrin promotes the reaction [quinocetone results in increased activity of CASP9 protein] zinc protoporphyrin inhibits the reaction [sesamol inhibits the reaction [Lipopolysaccharides results in increased activity of CASP9 protein]]; zinc protoporphyrin promotes the reaction [T-2 Toxin results in increased activity of CASP9 protein] |
CTD |
PMID:27375190 PMID:29432840 PMID:30261164 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions |
EXP ISO |
zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in decreased expression of CAT protein]] zinc protoporphyrin inhibits the reaction [8-oxoberberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of CAT protein]] |
CTD |
PMID:32621855 PMID:35691465 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccdc6 |
coiled-coil domain containing 6 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of CCDC6 mRNA |
CTD |
PMID:22839698 |
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NCBI chr20:18,432,177...18,528,186
Ensembl chr20:18,433,695...18,528,658
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
EXP ISO |
zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in decreased expression of CCL2 protein]; zinc protoporphyrin promotes the reaction [Indomethacin results in increased expression of CCL2 mRNA] zinc protoporphyrin inhibits the reaction [8-oxoberberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of CCL2 protein]] |
CTD |
PMID:20357190 PMID:23892052 PMID:35691465 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccr7 |
C-C motif chemokine receptor 7 |
multiple interactions |
ISO |
zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of CCR7 mRNA] |
CTD |
PMID:33049506 |
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NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309
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G |
Cd40 |
CD40 molecule |
multiple interactions |
ISO |
zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA] |
CTD |
PMID:33049506 |
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NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
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G |
Cd80 |
Cd80 molecule |
multiple interactions |
ISO |
zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 mRNA] |
CTD |
PMID:33049506 |
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NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
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G |
Cd83 |
CD83 molecule |
multiple interactions |
ISO |
zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of CD83 mRNA] |
CTD |
PMID:33049506 |
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NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083
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G |
Cd86 |
CD86 molecule |
multiple interactions |
ISO |
zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 mRNA] |
CTD |
PMID:33049506 |
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NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
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G |
Cdk13 |
cyclin-dependent kinase 13 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of CDK13 mRNA |
CTD |
PMID:22839698 |
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NCBI chr17:47,251,145...47,344,675
Ensembl chr17:47,251,163...47,341,721
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions |
ISO |
zinc protoporphyrin analog inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of and affects the localization of CDKN1A protein] |
CTD |
PMID:18508827 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Chd7 |
chromodomain helicase DNA binding protein 7 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of CHD7 mRNA |
CTD |
PMID:22839698 |
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NCBI chr 5:21,812,007...21,995,358
Ensembl chr 5:21,812,070...21,995,358
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G |
Cmbl |
carboxymethylenebutenolidase homolog |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of CMBL mRNA |
CTD |
PMID:22839698 |
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NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:82,571,888...82,591,009
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G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
increases expression |
EXP |
zinc protoporphyrin results in increased expression of CXCL1 mRNA |
CTD |
PMID:25780291 |
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NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
multiple interactions |
ISO |
zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]] |
CTD |
PMID:20861358 |
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NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
increases expression |
EXP |
zinc protoporphyrin results in increased expression of CXCL2 mRNA |
CTD |
PMID:25780291 |
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NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
EXP |
[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP1A1 protein |
CTD |
PMID:26747958 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions |
EXP |
[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP1A2 protein |
CTD |
PMID:26747958 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
multiple interactions |
EXP |
[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP2B1 protein |
CTD |
PMID:26747958 |
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NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions |
EXP ISO |
[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP2E1 mRNA; [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP2E1 protein; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 mRNA]; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 protein] zinc protoporphyrin inhibits the reaction [Quercetin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]]; zinc protoporphyrin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer inhibits the reaction [Ethanol results in increased activity of CYP2E1 protein]] |
CTD |
PMID:19325051 PMID:26747958 |
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Dcun1d1 |
defective in cullin neddylation 1 domain containing 1 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of DCUN1D1 mRNA |
CTD |
PMID:22839698 |
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NCBI chr 2:118,721,275...118,772,606
Ensembl chr 2:118,721,822...118,772,602
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions |
EXP |
zinc protoporphyrin promotes the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of DDIT3 protein]; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of DDIT3 protein] |
CTD |
PMID:26747958 |
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Dhx29 |
DExH-box helicase 29 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of DHX29 mRNA |
CTD |
PMID:22839698 |
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NCBI chr 2:44,560,653...44,611,450
Ensembl chr 2:44,560,714...44,611,445
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G |
Dusp10 |
dual specificity phosphatase 10 |
multiple interactions |
ISO |
zinc protoporphyrin inhibits the reaction [andrographolide results in increased expression of DUSP10 mRNA]; zinc protoporphyrin inhibits the reaction [andrographolide results in increased expression of DUSP10 protein] |
CTD |
PMID:29165873 |
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NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions |
EXP |
zinc protoporphyrin promotes the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased phosphorylation of EIF2AK3 protein]; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased phosphorylation of EIF2AK3 protein] |
CTD |
PMID:26747958 |
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NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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G |
Eml4 |
EMAP like 4 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of EML4 mRNA |
CTD |
PMID:22839698 |
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NCBI chr 6:11,219,545...11,334,824
Ensembl chr 6:11,219,566...11,334,879
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G |
F2 |
coagulation factor II, thrombin |
multiple interactions |
ISO |
zinc protoporphyrin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer inhibits the reaction [F2 protein results in increased expression of PTGS2 protein]]; zinc protoporphyrin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer inhibits the reaction [F2 protein results in increased secretion of Dinoprostone]] |
CTD |
PMID:26385185 |
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NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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G |
Faslg |
Fas ligand |
multiple interactions |
ISO |
zinc protoporphyrin inhibits the reaction [FASLG protein results in increased activity of CASP3 protein]; zinc protoporphyrin inhibits the reaction [FASLG protein results in increased activity of CASP8 protein]; zinc protoporphyrin inhibits the reaction [FASLG protein results in increased cleavage of CASP3 protein] |
CTD |
PMID:16051694 |
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NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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G |
Fbxw12 |
F-box and WD repeat domain containing 12 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of FBXW12 mRNA |
CTD |
PMID:22839698 |
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NCBI chr 8:109,782,315...109,802,086
Ensembl chr 8:109,786,815...109,801,813
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G |
Fgfr1 |
Fibroblast growth factor receptor 1 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of FGFR1 mRNA |
CTD |
PMID:22839698 |
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NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350
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G |
Flt1 |
Fms related receptor tyrosine kinase 1 |
multiple interactions |
ISO |
zinc protoporphyrin inhibits the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]] |
CTD |
PMID:25371888 |
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NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
zinc protoporphyrin results in increased expression of FOS mRNA |
CTD |
PMID:10381381 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Fut4 |
fucosyltransferase 4 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of FUT4 mRNA |
CTD |
PMID:22839698 |
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NCBI chr 8:11,586,721...11,590,682
Ensembl chr 8:11,586,721...11,590,682
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G |
Glul |
glutamate-ammonia ligase |
multiple interactions |
EXP |
zinc protoporphyrin inhibits the reaction [Resveratrol inhibits the reaction [Ammonia results in decreased activity of GLUL protein]]; zinc protoporphyrin inhibits the reaction [Resveratrol results in increased activity of GLUL protein] |
CTD |
PMID:26318273 |
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NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108
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G |
Gpr132 |
G protein-coupled receptor 132 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of GPR132 mRNA |
CTD |
PMID:22839698 |
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NCBI chr 6:131,924,061...131,943,327
Ensembl chr 6:131,924,160...131,942,168
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G |
Gpx1 |
glutathione peroxidase 1 |
multiple interactions |
ISO |
zinc protoporphyrin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of GPX1 protein] |
CTD |
PMID:36696656 |
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NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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G |
Gpx4 |
glutathione peroxidase 4 |
multiple interactions |
ISO |
zinc protoporphyrin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of GPX4 protein] |
CTD |
PMID:36696656 |
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NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
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G |
Gsdmd |
gasdermin D |
multiple interactions |
ISO |
zinc protoporphyrin inhibits the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased cleavage of GSDMD protein]] |
CTD |
PMID:36858639 |
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NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055
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G |
Gucy1a1 |
guanylate cyclase 1 soluble subunit alpha 1 |
multiple interactions |
EXP |
zinc protoporphyrin inhibits the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]] |
CTD |
PMID:19466990 |
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NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671
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G |
Gucy1b1 |
guanylate cyclase 1 soluble subunit beta 1 |
multiple interactions |
EXP |
zinc protoporphyrin inhibits the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]] |
CTD |
PMID:19466990 |
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NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916
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G |
Haus2 |
HAUS augmin like complex subunit 2 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of HAUS2 mRNA |
CTD |
PMID:22839698 |
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NCBI chr 3:107,553,146...107,565,982
Ensembl chr 3:107,553,161...107,565,157
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G |
Hfe |
homeostatic iron regulator |
affects abundance |
ISO |
HFE gene polymorphism affects the abundance of zinc protoporphyrin |
CTD |
PMID:25963508 |
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NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
ISO |
zinc protoporphyrin inhibits the reaction [HIF1A protein results in increased activity of SOD2 protein] |
CTD |
PMID:17066447 |
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NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Hmgb1 |
high mobility group box 1 |
multiple interactions |
EXP ISO |
zinc protoporphyrin promotes the reaction [lead acetate results in increased expression of HMGB1 mRNA] zinc protoporphyrin inhibits the reaction [sesamol inhibits the reaction [Lipopolysaccharides results in increased expression of HMGB1 protein]] |
CTD |
PMID:29447957 PMID:30261164 |
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NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions increases expression decreases activity affects expression decreases expression |
ISO EXP |
[zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [cobaltiprotoporphyrin results in increased expression of TP53 protein]; [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [neferine inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]]; [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [neferine inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]]; [zinc protoporphyrin results in decreased activity of HMOX1 protein] which results in increased susceptibility to 2-butenal; [zinc protoporphyrin results in decreased activity of HMOX1 protein] which results in increased susceptibility to Arsenic Trioxide; [zinc protoporphyrin results in decreased activity of HMOX1] which results in decreased susceptibility to peoniflorin; zinc protoporphyrin analog inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron]; zinc protoporphyrin inhibits the reaction [[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in decreased abundance of Glutathione]]; zinc protoporphyrin inhibits the reaction [[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in increased abundance of Malondialdehyde]]; zinc protoporphyrin inhibits the reaction [[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] which results in decreased susceptibility to Ethanol]; zinc protoporphyrin inhibits the reaction [ALB protein results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Cilostazol results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [Cilostazol results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased activity of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Dexmedetomidine promotes the reaction [Ropivacaine results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]]; zinc protoporphyrin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of HMOX1 protein]; zinc protoporphyrin promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; zinc protoporphyrin results in decreased expression of and results in decreased activity of HMOX1 protein; zinc protoporphyrin results in increased expression of and results in decreased activity of HMOX1 protein [zinc protoporphyrin co-treated with Hemin] results in increased expression of HMOX1 mRNA; [zinc protoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; ALB protein inhibits the reaction [zinc protoporphyrin results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [8-oxoberberine promotes the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HMOX1 mRNA]]; zinc protoporphyrin inhibits the reaction [8-oxoberberine promotes the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [[Lipopolysaccharides co-treated with 2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone] results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Cisplatin results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Glucose deficiency promotes the reaction [Simvastatin results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]; zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Resveratrol inhibits the reaction [Doxorubicin results in decreased expression of and results in decreased activity of HMOX1 protein]] [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of HMOX1 mRNA; [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with zinc protoporphyrin] results in increased expression of HMOX1 mRNA; [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]; [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [Resveratrol results in increased abundance of Glutathione]; [zinc protoporphyrin results in decreased activity of HMOX1 protein] which results in decreased susceptibility to Resveratrol; Hemin inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]]; Hemin inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Glucose results in decreased activity of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin promotes the reaction [Glucose results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Hemin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]]; zinc protoporphyrin inhibits the reaction [Hemin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]; zinc protoporphyrin inhibits the reaction [lead acetate results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [olprinone results in increased activity of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Propofol inhibits the reaction [Glucose results in decreased activity of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Propofol promotes the reaction [Glucose results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Sildenafil Citrate results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [Sildenafil Citrate results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Tadalafil promotes the reaction [Cisplatin results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of HMOX1 protein] zinc protoporphyrin results in increased expression of HMOX1 mRNA; zinc protoporphyrin results in increased expression of HMOX1 protein zinc protoporphyrin results in decreased activity of HMOX1; zinc protoporphyrin results in decreased activity of HMOX1 protein zinc protoporphyrin affects the expression of HMOX1 mRNA; zinc protoporphyrin affects the expression of HMOX1 protein zinc protoporphyrin results in decreased expression of HMOX1 mRNA; zinc protoporphyrin results in decreased expression of HMOX1 protein |
CTD |
PMID:7524564 PMID:12352873 PMID:14649057 PMID:15602829 PMID:16462769 PMID:17292349 PMID:17627722 PMID:17928392 PMID:18006204 PMID:18042465 PMID:18073186 PMID:18508827 PMID:19019021 PMID:19136476 PMID:19376148 PMID:19387321 PMID:19608869 PMID:20052772 PMID:20056245 PMID:20131233 PMID:20357190 PMID:20523338 PMID:21163135 PMID:21238556 PMID:21253390 PMID:21295052 PMID:21315065 PMID:21327864 PMID:21382476 PMID:21448202 PMID:21518603 PMID:21660147 PMID:21690482 PMID:21925249 PMID:22118543 PMID:22763982 PMID:22859313 PMID:22864849 PMID:23403272 PMID:23525258 PMID:23691207 PMID:23704825 PMID:24003391 PMID:24810525 PMID:25780291 PMID:25824035 PMID:26747958 PMID:27523796 PMID:27815112 PMID:27829220 PMID:27830717 PMID:29447957 PMID:31356851 PMID:32621855 PMID:33049506 PMID:34029560 PMID:35691465 PMID:36696656 PMID:36858639 More...
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hmox2 |
heme oxygenase 2 |
decreases activity decreases expression |
ISO EXP |
zinc protoporphyrin results in decreased activity of HMOX2 protein zinc protoporphyrin results in decreased expression of HMOX2 protein |
CTD |
PMID:21448202 PMID:25824035 |
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NCBI chr10:10,797,076...10,831,178
Ensembl chr10:10,797,055...10,831,148
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G |
Hp1bp3 |
heterochromatin protein 1, binding protein 3 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of HP1BP3 mRNA |
CTD |
PMID:22839698 |
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NCBI chr 5:150,435,781...150,463,004
Ensembl chr 5:150,433,740...150,463,000
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G |
Hsd11b1 |
hydroxysteroid 11-beta dehydrogenase 1 |
multiple interactions |
ISO |
zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased expression of HSD11B1 mRNA]] |
CTD |
PMID:27523796 |
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NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO EXP |
zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]] zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA] zinc protoporphyrin promotes the reaction [Indomethacin results in increased expression of ICAM1 mRNA] |
CTD |
PMID:19608869 PMID:23892052 PMID:33049506 |
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Ifnb1 |
interferon beta 1 |
multiple interactions |
ISO |
zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]] |
CTD |
PMID:20861358 |
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NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523
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G |
Ifng |
interferon gamma |
multiple interactions increases expression |
EXP |
zinc protoporphyrin inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased expression of HMOX1 protein] zinc protoporphyrin results in increased expression of IFNG mRNA |
CTD |
PMID:21295052 PMID:25780291 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Il10 |
interleukin 10 |
multiple interactions |
EXP |
zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of IL10 mRNA]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of IL10 protein] |
CTD |
PMID:20056245 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il12b |
interleukin 12B |
multiple interactions |
ISO |
zinc protoporphyrin promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA]] |
CTD |
PMID:33049506 |
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NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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G |
Il18 |
interleukin 18 |
multiple interactions |
ISO |
zinc protoporphyrin inhibits the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of IL18 protein]]; zinc protoporphyrin inhibits the reaction [Hemin results in decreased susceptibility to IL18 protein] |
CTD |
PMID:18215737 PMID:36858639 |
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NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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G |
Il1b |
interleukin 1 beta |
multiple interactions increases expression |
ISO EXP |
zinc protoporphyrin inhibits the reaction [Cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; zinc protoporphyrin inhibits the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of IL1B protein]] zinc protoporphyrin inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased expression of HMOX1 protein]; zinc protoporphyrin promotes the reaction [Indomethacin results in increased expression of IL1B mRNA] zinc protoporphyrin results in increased expression of IL1B mRNA zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; zinc protoporphyrin inhibits the reaction [8-oxoberberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL1B protein]]; zinc protoporphyrin inhibits the reaction [sesamol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]] |
CTD |
PMID:20131233 PMID:21295052 PMID:23892052 PMID:25780291 PMID:27523796 PMID:30261164 PMID:35691465 PMID:36858639 More...
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il23a |
interleukin 23 subunit alpha |
multiple interactions |
ISO |
zinc protoporphyrin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased expression of IL23A mRNA]]; zinc protoporphyrin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL23A protein]] |
CTD |
PMID:33049506 |
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NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
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G |
Il6 |
interleukin 6 |
multiple interactions increases expression |
ISO EXP |
zinc protoporphyrin inhibits the reaction [cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of IL6 protein]] zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; zinc protoporphyrin inhibits the reaction [8-oxoberberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; zinc protoporphyrin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]; zinc protoporphyrin inhibits the reaction [manganese chloride promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [sesamol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]] zinc protoporphyrin results in increased expression of IL6 mRNA |
CTD |
PMID:19608869 PMID:20131233 PMID:21963524 PMID:25780291 PMID:27523796 PMID:30261164 PMID:33049506 PMID:35691465 More...
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Inpp5d |
inositol polyphosphate-5-phosphatase D |
decreases expression |
EXP |
zinc protoporphyrin results in decreased expression of INPP5D protein |
CTD |
PMID:25780291 |
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NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746
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G |
Irak1 |
interleukin-1 receptor-associated kinase 1 |
multiple interactions |
EXP |
zinc protoporphyrin promotes the reaction [IRAK1 protein binds to MYD88 protein] |
CTD |
PMID:25780291 |
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NCBI chr X:151,768,621...151,778,521
Ensembl chr X:151,768,777...151,778,521
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G |
Irak3 |
interleukin-1 receptor-associated kinase 3 |
decreases expression |
EXP |
zinc protoporphyrin results in decreased expression of IRAK3 protein |
CTD |
PMID:25780291 |
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NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121
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G |
Itgam |
integrin subunit alpha M |
increases expression |
ISO |
zinc protoporphyrin results in increased expression of ITGAM protein |
CTD |
PMID:22118543 |
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NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases expression |
ISO |
zinc protoporphyrin promotes the reaction [arsenic trioxide results in increased expression of JUN protein] zinc protoporphyrin results in increased expression of JUN protein |
CTD |
PMID:27829220 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Kcnab1 |
potassium voltage-gated channel subfamily A regulatory beta subunit 1 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of KCNAB1 mRNA |
CTD |
PMID:22839698 |
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NCBI chr 2:149,137,025...149,603,540
Ensembl chr 2:149,137,041...149,603,534
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G |
Kctd20 |
potassium channel tetramerization domain containing 20 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of KCTD20 mRNA |
CTD |
PMID:22839698 |
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NCBI chr20:7,015,828...7,032,766
Ensembl chr20:7,015,833...7,032,761
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G |
Kidins220 |
kinase D-interacting substrate 220 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of KIDINS220 mRNA |
CTD |
PMID:22839698 |
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NCBI chr 6:41,618,207...41,706,990
Ensembl chr 6:41,618,294...41,703,256
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G |
Kitlg |
KIT ligand |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of KITLG mRNA |
CTD |
PMID:22839698 |
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NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214
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G |
Kras |
KRAS proto-oncogene, GTPase |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of KRAS mRNA |
CTD |
PMID:22839698 |
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NCBI chr 4:178,185,418...178,218,484
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G |
Larp1b |
La ribonucleoprotein 1B |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of LARP1B mRNA |
CTD |
PMID:22839698 |
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NCBI chr 2:123,936,057...123,969,254
Ensembl chr 2:123,935,983...123,968,896
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G |
Ldha |
lactate dehydrogenase A |
multiple interactions |
ISO |
zinc protoporphyrin inhibits the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of LDHA protein]] |
CTD |
PMID:36858639 |
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NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
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G |
Lnx1 |
ligand of numb-protein X 1 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of LNX1 mRNA |
CTD |
PMID:22839698 |
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NCBI chr14:33,514,429...33,617,086
Ensembl chr14:33,514,436...33,617,086
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G |
Lyrm7 |
LYR motif containing 7 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of LYRM7 mRNA |
CTD |
PMID:22839698 |
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NCBI chr10:38,964,299...38,983,628
Ensembl chr10:38,964,311...38,983,601
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G |
Macf1 |
microtubule-actin crosslinking factor 1 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of MACF1 mRNA |
CTD |
PMID:22839698 |
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NCBI chr 5:135,623,734...135,949,097
Ensembl chr 5:135,623,742...135,945,905
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases phosphorylation |
ISO |
[zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [neferine inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]] zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]]; zinc protoporphyrin promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; zinc protoporphyrin promotes the reaction [lipoteichoic acid results in increased phosphorylation of MAPK1 protein]; zinc protoporphyrin promotes the reaction [Peptidoglycan results in increased phosphorylation of MAPK1 protein] zinc protoporphyrin results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:19376148 PMID:20523338 PMID:27523796 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions increases phosphorylation |
ISO |
[zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [neferine inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]] zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]]; zinc protoporphyrin promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; zinc protoporphyrin promotes the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein]; zinc protoporphyrin promotes the reaction [Peptidoglycan results in increased phosphorylation of MAPK3 protein] zinc protoporphyrin results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:19376148 PMID:20523338 PMID:27523796 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mark2 |
microtubule affinity regulating kinase 2 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of MARK2 mRNA |
CTD |
PMID:22839698 |
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NCBI chr 1:204,461,029...204,526,247
Ensembl chr 1:204,461,030...204,525,652
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G |
Mfn1 |
mitofusin 1 |
multiple interactions |
EXP |
Hemin inhibits the reaction [zinc protoporphyrin promotes the reaction [Lipopolysaccharides results in decreased expression of MFN1 mRNA]]; Hemin inhibits the reaction [zinc protoporphyrin promotes the reaction [Lipopolysaccharides results in decreased expression of MFN1 protein]]; zinc protoporphyrin inhibits the reaction [Hemin inhibits the reaction [Lipopolysaccharides results in decreased expression of MFN1 mRNA]]; zinc protoporphyrin inhibits the reaction [Hemin inhibits the reaction [Lipopolysaccharides results in decreased expression of MFN1 protein]]; zinc protoporphyrin promotes the reaction [Lipopolysaccharides results in decreased expression of MFN1 mRNA]; zinc protoporphyrin promotes the reaction [Lipopolysaccharides results in decreased expression of MFN1 protein] |
CTD |
PMID:27830717 |
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NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640
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G |
Mllt3 |
MLLT3, super elongation complex subunit |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of MLLT3 mRNA |
CTD |
PMID:22839698 |
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NCBI chr 5:102,259,075...102,515,447
Ensembl chr 5:102,260,011...102,515,361
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G |
Mmp2 |
matrix metallopeptidase 2 |
affects expression multiple interactions |
EXP ISO |
zinc protoporphyrin affects the expression of MMP2 zinc protoporphyrin inhibits the reaction [fisetin results in decreased expression of MMP2 mRNA]; zinc protoporphyrin inhibits the reaction [fisetin results in decreased expression of MMP2 protein] |
CTD |
PMID:23704825 PMID:30076913 |
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NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
ISO |
zinc protoporphyrin promotes the reaction [arsenic trioxide results in increased expression of MMP9 protein] zinc protoporphyrin inhibits the reaction [fisetin results in decreased expression of MMP9 mRNA]; zinc protoporphyrin inhibits the reaction [fisetin results in decreased expression of MMP9 protein] |
CTD |
PMID:27829220 PMID:30076913 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mpo |
myeloperoxidase |
multiple interactions |
EXP |
zinc protoporphyrin promotes the reaction [Indomethacin results in increased activity of MPO protein]; zinc protoporphyrin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] |
CTD |
PMID:17292349 PMID:23892052 |
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NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Myd88 |
MYD88, innate immune signal transduction adaptor |
multiple interactions |
EXP |
zinc protoporphyrin promotes the reaction [IRAK1 protein binds to MYD88 protein]; zinc protoporphyrin promotes the reaction [TLR2 protein binds to MYD88 protein]; zinc protoporphyrin promotes the reaction [TLR4 protein binds to MYD88 protein]; zinc protoporphyrin promotes the reaction [TRAF6 protein binds to MYD88 protein] |
CTD |
PMID:25780291 |
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NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
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G |
Ncf1 |
neutrophil cytosolic factor 1 |
multiple interactions |
ISO |
zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein promotes the reaction [SRC protein binds to NCF1 protein]]] |
CTD |
PMID:19608869 |
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NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions affects expression |
EXP |
zinc protoporphyrin inhibits the reaction [Hemin results in increased expression of NFE2L2 protein] zinc protoporphyrin affects the expression of NFE2L2 mRNA; zinc protoporphyrin affects the expression of NFE2L2 protein |
CTD |
PMID:23704825 PMID:25824035 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
zinc protoporphyrin inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides affects the localization of [RELA protein binds to NFKB1 protein]]] |
CTD |
PMID:21925249 |
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
zinc protoporphyrin inhibits the reaction [cilostazol results in increased expression of NFKBIA protein]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of NFKBIA protein] zinc protoporphyrin inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]] |
CTD |
PMID:20131233 PMID:21925249 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nos1 |
nitric oxide synthase 1 |
multiple interactions |
EXP |
[Sildenafil Citrate co-treated with zinc protoporphyrin] results in increased expression of NOS1 mRNA |
CTD |
PMID:17627722 |
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NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO EXP |
[zinc protoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [Peptidoglycan results in increased expression of NOS2 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [zinc protoporphyrin inhibits the reaction [Peptidoglycan results in increased expression of NOS2 protein]]; lactacystin inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; lactacystin inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; lactacystin inhibits the reaction [zinc protoporphyrin inhibits the reaction [Peptidoglycan results in increased expression of NOS2 protein]]; pyrazolanthrone inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; pyrazolanthrone inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; pyrazolanthrone inhibits the reaction [zinc protoporphyrin inhibits the reaction [Peptidoglycan results in increased expression of NOS2 protein]]; zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; zinc protoporphyrin inhibits the reaction [Peptidoglycan results in increased expression of NOS2 protein]; zinc protoporphyrin inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]] [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of NOS2 mRNA; [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of NOS2 protein; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in decreased expression of NOS2 protein]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of NOS2 mRNA]]; zinc protoporphyrin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer inhibits the reaction [Ethanol results in increased expression of NOS2 mRNA]]; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of NOS2 mRNA]; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of NOS2 protein] |
CTD |
PMID:19376148 PMID:20357190 PMID:21925249 PMID:26460608 PMID:26747958 PMID:32621855 More...
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Pde4dip |
phosphodiesterase 4D interacting protein |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of PDE4DIP mRNA |
CTD |
PMID:22839698 |
|
NCBI chr 2:185,293,236...185,490,100
Ensembl chr 2:185,293,214...185,468,379
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G |
Pgf |
placental growth factor |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of PGF mRNA |
CTD |
PMID:22839698 |
|
NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685
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G |
Polr3k |
RNA polymerase III subunit K |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of POLR3K mRNA |
CTD |
PMID:22839698 |
|
NCBI chr 3:168,982,846...168,987,043
Ensembl chr 3:168,982,812...168,987,040
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
ISO |
zinc protoporphyrin inhibits the reaction [cilostazol results in increased activity of PPARG protein]; zinc protoporphyrin inhibits the reaction [rosiglitazone results in increased activity of PPARG protein] |
CTD |
PMID:21660147 |
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Ppil1 |
peptidylprolyl isomerase like 1 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of PPIL1 mRNA |
CTD |
PMID:22839698 |
|
NCBI chr20:7,302,292...7,322,349
Ensembl chr20:7,302,621...7,322,354
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G |
Prdx2 |
peroxiredoxin 2 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of PRDX2 mRNA |
CTD |
PMID:22839698 |
|
NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194
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G |
Prr11 |
proline rich 11 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of PRR11 mRNA |
CTD |
PMID:22839698 |
|
NCBI chr10:71,898,858...71,943,325
Ensembl chr10:71,901,202...71,921,012
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
zinc protoporphyrin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer inhibits the reaction [F2 protein results in increased expression of PTGS2 protein]]; zinc protoporphyrin promotes the reaction [Arsenic Trioxide results in increased expression of PTGS2] zinc protoporphyrin inhibits the reaction [sesamol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]; zinc protoporphyrin promotes the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] |
CTD |
PMID:23649692 PMID:24003391 PMID:26385185 PMID:30261164 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Ptpn12 |
protein tyrosine phosphatase, non-receptor type 12 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of PTPN12 mRNA |
CTD |
PMID:22839698 |
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NCBI chr 4:14,020,997...14,092,931
Ensembl chr 4:14,021,052...14,092,927
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G |
Ptpro |
protein tyrosine phosphatase, receptor type, O |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of PTPRO mRNA |
CTD |
PMID:22839698 |
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NCBI chr 4:170,164,071...170,374,790
Ensembl chr 4:170,164,431...170,374,771
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G |
Rap2c |
RAP2C, member of RAS oncogene family |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of RAP2C mRNA |
CTD |
PMID:22839698 |
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NCBI chr X:130,504,554...130,517,671
Ensembl chr X:130,504,698...130,518,328
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO EXP |
zinc protoporphyrin inhibits the reaction [cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]]; zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased expression of RELA mRNA]]; zinc protoporphyrin promotes the reaction [quinocetone results in increased expression of RELA mRNA] zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased localization of and results in increased activity of RELA protein]]; zinc protoporphyrin inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides affects the localization of [RELA protein binds to NFKB1 protein]]]; zinc protoporphyrin inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein modified form]] zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in decreased expression of RELA protein] |
CTD |
PMID:19608869 PMID:20131233 PMID:20357190 PMID:21925249 PMID:27375190 PMID:27523796 More...
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Rgcc |
regulator of cell cycle |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of RGCC mRNA |
CTD |
PMID:22839698 |
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NCBI chr15:54,662,483...54,675,320
Ensembl chr15:54,662,483...54,681,141
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G |
Scaf11 |
SR-related CTD-associated factor 11 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of SCAF11 mRNA |
CTD |
PMID:22839698 |
|
NCBI chr 7:127,571,678...127,624,089
Ensembl chr 7:127,574,463...127,624,101
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G |
Scamp1 |
secretory carrier membrane protein 1 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of SCAMP1 mRNA |
CTD |
PMID:22839698 |
|
NCBI chr 2:25,433,958...25,516,734
Ensembl chr 2:25,433,959...25,516,673
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G |
Sec23b |
Sec23 homolog B, COPII coat complex component |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of SEC23B mRNA |
CTD |
PMID:22839698 |
|
NCBI chr 3:131,939,011...131,981,489
Ensembl chr 3:131,939,337...131,981,489
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G |
Sel1l |
SEL1L adaptor subunit of SYVN1 ubiquitin ligase |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of SEL1L mRNA |
CTD |
PMID:22839698 |
|
NCBI chr 6:110,735,450...110,779,695
Ensembl chr 6:110,735,450...110,779,648
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G |
Sirt1 |
sirtuin 1 |
multiple interactions |
ISO |
zinc protoporphyrin inhibits the reaction [Fenofibrate results in increased expression of SIRT1 protein] |
CTD |
PMID:34520103 |
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NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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G |
Slc22a3 |
solute carrier family 22 member 3 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of SLC22A3 mRNA |
CTD |
PMID:22839698 |
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NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
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G |
Slc35e1 |
solute carrier family 35, member E1 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of SLC35E1 mRNA |
CTD |
PMID:22839698 |
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NCBI chr16:17,350,938...17,364,185
Ensembl chr16:17,350,988...17,363,268
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G |
Smcr8 |
SMCR8-C9orf72 complex subunit |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of SMCR8 mRNA |
CTD |
PMID:22839698 |
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NCBI chr10:45,457,962...45,465,101
Ensembl chr10:45,457,605...45,468,876
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G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of SOD2 mRNA; zinc protoporphyrin inhibits the reaction [HIF1A protein results in increased activity of SOD2 protein] |
CTD |
PMID:17066447 PMID:22839698 |
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NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Sptbn1 |
spectrin, beta, non-erythrocytic 1 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of SPTBN1 mRNA |
CTD |
PMID:22839698 |
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NCBI chr14:103,841,713...104,016,900
Ensembl chr14:103,842,684...104,008,507
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G |
Src |
SRC proto-oncogene, non-receptor tyrosine kinase |
multiple interactions |
ISO |
zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein promotes the reaction [SRC protein binds to NCF1 protein]]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein promotes the reaction [SRC protein binds to TNFRSF1A protein]]] |
CTD |
PMID:19608869 |
|
NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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G |
Ssbp3 |
single stranded DNA binding protein 3 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of SSBP3 mRNA |
CTD |
PMID:22839698 |
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NCBI chr 5:121,691,370...121,828,035
Ensembl chr 5:121,691,393...121,827,992
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G |
St3gal1 |
ST3 beta-galactoside alpha-2,3-sialyltransferase 1 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of ST3GAL1 mRNA |
CTD |
PMID:22839698 |
|
NCBI chr 7:98,845,270...98,913,409
Ensembl chr 7:98,845,270...98,913,236
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G |
Stat1 |
signal transducer and activator of transcription 1 |
multiple interactions |
ISO |
zinc protoporphyrin inhibits the reaction [Ozone results in increased phosphorylation of STAT1 protein] |
CTD |
PMID:19061877 |
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NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
EXP ISO |
zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Glucose results in decreased phosphorylation of STAT3 protein]]; zinc protoporphyrin inhibits the reaction [Propofol inhibits the reaction [Glucose results in decreased phosphorylation of STAT3 protein]] zinc protoporphyrin inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein] |
CTD |
PMID:24095726 PMID:24810525 |
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NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Tgfb1 |
transforming growth factor, beta 1 |
affects expression increases expression decreases secretion |
EXP |
zinc protoporphyrin affects the expression of TGFB1 zinc protoporphyrin results in increased expression of TGFB1 protein zinc protoporphyrin results in decreased secretion of TGFB1 protein |
CTD |
PMID:21163135 PMID:23525258 PMID:23704825 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
affects expression multiple interactions |
EXP ISO |
zinc protoporphyrin affects the expression of TIMP1 zinc protoporphyrin promotes the reaction [ALB protein results in increased expression of TIMP1 protein] |
CTD |
PMID:21163135 PMID:23704825 |
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NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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G |
Tlr2 |
toll-like receptor 2 |
multiple interactions |
EXP |
zinc protoporphyrin promotes the reaction [TLR2 protein binds to MYD88 protein] |
CTD |
PMID:25780291 |
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NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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G |
Tlr4 |
toll-like receptor 4 |
multiple interactions |
EXP |
zinc protoporphyrin promotes the reaction [TLR4 protein binds to MYD88 protein] |
CTD |
PMID:25780291 |
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NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO EXP |
zinc protoporphyrin inhibits the reaction [cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; zinc protoporphyrin inhibits the reaction [cilostazol results in decreased susceptibility to TNF protein]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein promotes the reaction [SRC protein binds to NCF1 protein]]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein promotes the reaction [SRC protein binds to TNFRSF1A protein]]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]] zinc protoporphyrin inhibits the reaction [8-oxoberberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of TNF protein]]; zinc protoporphyrin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; zinc protoporphyrin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased localization of and results in increased activity of RELA protein]]; zinc protoporphyrin inhibits the reaction [manganese chloride promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]]; zinc protoporphyrin inhibits the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; zinc protoporphyrin inhibits the reaction [sesamol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; zinc protoporphyrin inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]] [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of TNF mRNA; [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of TNF protein; zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; zinc protoporphyrin inhibits the reaction [naringenin results in decreased activity of TNF protein]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of TNF protein]]; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of TNF mRNA]; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of TNF protein] |
CTD |
PMID:19608869 PMID:20052772 PMID:20131233 PMID:21660147 PMID:21925249 PMID:21963524 PMID:22709785 PMID:24095726 PMID:26747958 PMID:30261164 PMID:32621855 PMID:33049506 PMID:35691465 More...
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfrsf1a |
TNF receptor superfamily member 1A |
multiple interactions |
ISO |
zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein promotes the reaction [SRC protein binds to TNFRSF1A protein]]] |
CTD |
PMID:19608869 |
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NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
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G |
Tnrc6a |
trinucleotide repeat containing adaptor 6A |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of TNRC6A mRNA |
CTD |
PMID:22839698 |
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NCBI chr 1:177,561,898...177,715,669
Ensembl chr 1:177,646,030...177,715,660
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G |
Tollip |
toll interacting protein |
decreases expression |
EXP |
zinc protoporphyrin results in decreased expression of TOLLIP protein |
CTD |
PMID:25780291 |
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NCBI chr 1:196,961,585...196,984,252
Ensembl chr 1:196,950,771...196,983,625
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO EXP |
[zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [cobaltiprotoporphyrin results in increased expression of TP53 protein] zinc protoporphyrin inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of TRP53 protein]] zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in decreased expression of TP53 protein] |
CTD |
PMID:18042465 PMID:20357190 PMID:22763982 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Traf6 |
TNF receptor associated factor 6 |
multiple interactions |
EXP |
zinc protoporphyrin promotes the reaction [TRAF6 protein binds to MYD88 protein] |
CTD |
PMID:25780291 |
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NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
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G |
Ubxn2a |
UBX domain protein 2A |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of UBXN2A mRNA |
CTD |
PMID:22839698 |
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NCBI chr 6:27,884,364...27,912,767
Ensembl chr 6:27,884,680...27,912,649 Ensembl chr20:27,884,680...27,912,649
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G |
Usp13 |
ubiquitin specific peptidase 13 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of USP13 mRNA |
CTD |
PMID:22839698 |
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NCBI chr 2:115,576,912...115,689,153
Ensembl chr 2:115,577,091...115,686,222
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G |
Usp34 |
ubiquitin specific peptidase 34 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of USP34 mRNA |
CTD |
PMID:22839698 |
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NCBI chr14:97,285,799...97,476,376
Ensembl chr14:97,286,018...97,476,376
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
ISO EXP |
zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]] zinc protoporphyrin promotes the reaction [Indomethacin results in increased expression of VCAM1 mRNA] |
CTD |
PMID:19608869 PMID:23892052 |
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NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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G |
Vdr |
vitamin D receptor |
affects abundance |
ISO |
VDR gene polymorphism affects the abundance of zinc protoporphyrin |
CTD |
PMID:25963508 |
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NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
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G |
Vps33a |
VPS33A core subunit of CORVET and HOPS complexes |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of VPS33A mRNA |
CTD |
PMID:22839698 |
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NCBI chr12:33,024,596...33,051,399
Ensembl chr12:33,024,650...33,051,393
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G |
Wsb2 |
WD repeat and SOCS box-containing 2 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of WSB2 mRNA |
CTD |
PMID:22839698 |
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NCBI chr12:39,217,645...39,238,634
Ensembl chr12:39,217,648...39,238,640
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G |
Zfp36 |
zinc finger protein 36 |
multiple interactions |
ISO |
zinc protoporphyrin inhibits the reaction [[Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of ZFP36 mRNA]; zinc protoporphyrin inhibits the reaction [Hemin results in increased expression of ZFP36 mRNA]; zinc protoporphyrin inhibits the reaction [Nicotine results in increased expression of ZFP36 mRNA] |
CTD |
PMID:24095726 |
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NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
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G |
Zfp827 |
zinc finger protein 827 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of ZNF827 mRNA |
CTD |
PMID:22839698 |
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NCBI chr19:28,720,568...28,887,381
Ensembl chr19:28,721,021...28,887,191
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G |
Zfyve16 |
zinc finger FYVE-type containing 16 |
multiple interactions |
ISO |
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of ZFYVE16 mRNA |
CTD |
PMID:22839698 |
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NCBI chr 2:23,713,018...23,757,576
Ensembl chr 2:23,713,766...23,756,990
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