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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fluoxetine hydrochloride
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Accession:CHEBI:5119 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine hydrochloride. A selective serotonin reuptake inhibitor (SSRI), it is used for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
Synonyms:exact_synonym: rac-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine hydrochloride
 related_synonym: (+-)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine hydrochloride;   (+-)-methyl-gamma-[4-(trifluoromethyl)phenoxy]benzenepropanamine hydrochloride;   3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine hydrochloride;   Adofen;   Affectine;   Ansilan;   Deproxin;   Digassim;   Erocap;   Fluctin;   Fluctine;   Fludac;   Flufran;   Flunil;   Fluox-Puren;   Fluoxac;   Fluoxeren;   Fluoxil;   Flutin;   Flutine;   Fluxen;   Fluxil;   Fontex;   Formula=C17H19ClF3NO;   Foxetin;   LY 110140;   LY110140;   Lilly 110140;   Lorien;   Lovan;   Margrilan;   Modipran;   Neupax;   Nopres;   Nuzak;   Oxedep;   Pragmaten;   Prizma;   Proctin;   Prodep;   Profluzac;   Prozac;   Reconcile;   Rowexetina;   Sanzur;   Sarafem;   Selfemra;   Sinzac;   Zactin;   Zepax;   fluoxetine HCl;   rac-fluoxetine hydrochloride
 xref: CAS:56296-78-7;   CAS:59333-67-4;   DrugBank:DB00472;   KEGG:D00823;   PMCID:PMC3894728;   PMID:16121130;   PMID:19144769;   PMID:23885544;   PMID:24503458;   PMID:24615023;   PMID:24785765;   PMID:25685415;   Reaxys:27994391;   Reaxys:6759273;   Wikipedia:Fluoxetine



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fluoxetine hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc6a4 solute carrier family 6 member 4 decreases expression EXP fluoxetine decreases expression of Slc6a4 mRNA in the dorsal raphe nucleus RGD PMID:15936043 RGD:38549581 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        pharmacological role 18837
          analgesic 13308
            fluoxetine hydrochloride 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      halogen 18184
                        chlorine atom 18027
                          chlorine molecular entity 18027
                            elemental chlorine 8463
                              monoatomic chlorine 8447
                                chloride 8447
                                  chloride salt 8447
                                    organic chloride salt 918
                                      hydrochloride 686
                                        (R)-fluoxetine hydrochloride 1
                                          fluoxetine hydrochloride 1
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