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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fluoxetine hydrochloride
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Accession:CHEBI:5119 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine hydrochloride. A selective serotonin reuptake inhibitor (SSRI), it is used for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
Synonyms:exact_synonym: rac-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine hydrochloride
 related_synonym: (+-)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine hydrochloride;   (+-)-methyl-gamma-[4-(trifluoromethyl)phenoxy]benzenepropanamine hydrochloride;   3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine hydrochloride;   Adofen;   Affectine;   Ansilan;   Deproxin;   Digassim;   Erocap;   Fluctin;   Fluctine;   Fludac;   Flufran;   Flunil;   Fluox-Puren;   Fluoxac;   Fluoxeren;   Fluoxil;   Flutin;   Flutine;   Fluxen;   Fluxil;   Fontex;   Formula=C17H19ClF3NO;   Foxetin;   LY 110140;   LY110140;   Lilly 110140;   Lorien;   Lovan;   Margrilan;   Modipran;   Neupax;   Nopres;   Nuzak;   Oxedep;   Pragmaten;   Prizma;   Proctin;   Prodep;   Profluzac;   Prozac;   Reconcile;   Rowexetina;   Sanzur;   Sarafem;   Selfemra;   Sinzac;   Zactin;   Zepax;   fluoxetine HCl;   rac-fluoxetine hydrochloride
 xref: CAS:56296-78-7;   CAS:59333-67-4;   DrugBank:DB00472;   KEGG:D00823;   PMCID:PMC3894728;   PMID:16121130;   PMID:19144769;   PMID:23885544;   PMID:24503458;   PMID:24615023;   PMID:24785765;   PMID:25685415;   Reaxys:27994391;   Reaxys:6759273;   Wikipedia:Fluoxetine


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fluoxetine hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc6a4 solute carrier family 6 member 4 decreases expression EXP fluoxetine decreases expression of Slc6a4 mRNA in the dorsal raphe nucleus RGD PMID:15936043 RGD:38549581 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
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Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        pharmacological role 18847
          analgesic 13302
            fluoxetine hydrochloride 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      halogen 18171
                        chlorine atom 18008
                          chlorine molecular entity 18008
                            elemental chlorine 8453
                              monoatomic chlorine 8437
                                chloride 8437
                                  chloride salt 8437
                                    organic chloride salt 908
                                      hydrochloride 687
                                        (R)-fluoxetine hydrochloride 1
                                          fluoxetine hydrochloride 1
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