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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:fluoxetine hydrochloride
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Accession:CHEBI:5119 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine hydrochloride. A selective serotonin reuptake inhibitor (SSRI), it is used for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
Synonyms:exact_synonym: rac-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine hydrochloride
 related_synonym: (+-)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine hydrochloride;   (+-)-methyl-gamma-[4-(trifluoromethyl)phenoxy]benzenepropanamine hydrochloride;   3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine hydrochloride;   Adofen;   Affectine;   Ansilan;   Deproxin;   Digassim;   Erocap;   Fluctin;   Fluctine;   Fludac;   Flufran;   Flunil;   Fluox-Puren;   Fluoxac;   Fluoxeren;   Fluoxil;   Flutin;   Flutine;   Fluxen;   Fluxil;   Fontex;   Formula=C17H19ClF3NO;   Foxetin;   LY 110140;   LY110140;   Lilly 110140;   Lorien;   Lovan;   Margrilan;   Modipran;   Neupax;   Nopres;   Nuzak;   Oxedep;   Pragmaten;   Prizma;   Proctin;   Prodep;   Profluzac;   Prozac;   Reconcile;   Rowexetina;   Sanzur;   Sarafem;   Selfemra;   Sinzac;   Zactin;   Zepax;   fluoxetine HCl;   rac-fluoxetine hydrochloride
 xref: CAS:56296-78-7;   CAS:59333-67-4;   DrugBank:DB00472;   KEGG:D00823;   PMCID:PMC3894728;   PMID:16121130;   PMID:19144769;   PMID:23885544;   PMID:24503458;   PMID:24615023;   PMID:24785765;   PMID:25685415;   Reaxys:27994391;   Reaxys:6759273;   Wikipedia:Fluoxetine


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fluoxetine hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc6a4 solute carrier family 6 member 4 decreases expression EXP fluoxetine decreases expression of Slc6a4 mRNA in the dorsal raphe nucleus RGD PMID:15936043 RGD:38549581 NCBI chr10:62,322,688...62,357,060
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19909
    role 19880
      biological role 19878
        pharmacological role 19113
          analgesic 14789
            fluoxetine hydrochloride 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19909
    subatomic particle 19907
      composite particle 19907
        hadron 19907
          baryon 19907
            nucleon 19907
              atomic nucleus 19907
                atom 19907
                  main group element atom 19846
                    p-block element atom 19846
                      halogen 18717
                        chlorine atom 18496
                          chlorine molecular entity 18496
                            elemental chlorine 10077
                              monoatomic chlorine 10066
                                chloride 10066
                                  chloride salt 10066
                                    organic chloride salt 1109
                                      hydrochloride 739
                                        (R)-fluoxetine hydrochloride 1
                                          fluoxetine hydrochloride 1
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