The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
BIRC5 protein results in decreased susceptibility to Noscapine Noscapine results in increased expression of BIRC5 mRNA; Noscapine results in increased expression of BIRC5 protein Noscapine results in decreased expression of BIRC5 protein Noscapine promotes the reaction [Cisplatin results in decreased expression of BIRC5 protein]
[Noscapine co-treated with Cisplatin] results in increased cleavage of CASP3 protein; Noscapine promotes the reaction [Cisplatin results in increased expression of and results in increased cleavage of CASP3 protein]; Noscapine results in increased expression of and results in increased cleavage of CASP3 protein Noscapine results in increased activity of CASP3 protein
Noscapine promotes the reaction [Cisplatin results in increased expression of and results in increased cleavage of CASP9 protein]; Noscapine results in increased expression of and results in increased cleavage of CASP9 protein
Noscapine promotes the reaction [Cisplatin results in increased expression of CDKN1A protein] Noscapine results in increased expression of CDKN1A protein
Noscapine promotes the reaction [Cisplatin results in increased expression of TP53 protein]; Noscapine results in increased expression of and results in increased phosphorylation of TP53 protein Noscapine results in increased expression of TP53 protein
ABCB1 protein inhibits the reaction [germacrone results in increased susceptibility to Doxorubicin]; germacrone inhibits the reaction [Doxorubicin results in increased expression of ABCB1 mRNA]; germacrone inhibits the reaction [Doxorubicin results in increased expression of ABCB1 protein]
Tramadol affects the activity of CASP3 protein Vitamin E inhibits the reaction [Tramadol results in increased expression of CASP3 protein] Tramadol results in decreased activity of CASP3 protein
Tramadol results in decreased expression of CAT mRNA; Tramadol results in decreased expression of CAT protein Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of CAT mRNA]
Tramadol results in decreased expression of CKB mRNA Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein]
Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein]
CYP2D6 gene mutant form affects the metabolism of Tramadol; CYP2D6 gene polymorphism affects the metabolism of Tramadol CYP2D6 protein affects the methylation of Tramadol [CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol] which results in increased chemical synthesis of O-demethyltramadol; CYP2D6 gene polymorphism affects the metabolism of and affects the susceptibility to Tramadol; CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol CYP2D6 protein results in decreased methylation of Tramadol CYP2D6 affects the susceptibility to Tramadol; CYP2D6 gene polymorphism affects the susceptibility to Tramadol; CYP2D6 protein affects the susceptibility to Tramadol CYP2D6 gene polymorphism results in decreased susceptibility to Tramadol CYP2D6 gene mutant form results in increased susceptibility to Tramadol CYP2D6 gene mutant form results in increased metabolism of Tramadol; CYP2D6 protein results in increased metabolism of Tramadol
Tramadol results in increased activity of HTR2A protein Tramadol results in increased expression of HTR2A mRNA Ketanserin inhibits the reaction [Tramadol results in increased activity of HTR2A protein]
Tramadol binds to OPRD1 protein [Tramadol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRD1 protein] which results in decreased uptake of Serotonin
Tramadol binds to OPRK1 protein [Tramadol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRK1 protein] which results in decreased uptake of Serotonin
Tramadol binds to OPRM1 protein [Tramadol binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRM1 protein] which results in decreased uptake of Serotonin
Naloxone inhibits the reaction [Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]
Tramadol results in decreased expression of SOD1 mRNA; Tramadol results in decreased expression of SOD1 protein Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD1 mRNA]
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD2 mRNA] Tramadol results in decreased expression of SOD2 mRNA
Ethanol promotes the reaction [Tramadol results in increased expression of SPP1 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of SPP1 protein]
[Acetaminophen co-treated with Tramadol] inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNF protein]; Vitamin E inhibits the reaction [Tramadol results in increased expression of TNF protein]
Ethanol promotes the reaction [Tramadol results in increased expression of TNNI3 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNNI3 protein]
CYP2D6 protein affects the metabolism of Codeine; CYP2D6 protein polymorphism affects the metabolism of Codeine [CYP2D6 gene mutant form results in increased activity of CYP2D6 protein] which results in increased susceptibility to Codeine; [CYP2D6 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of Morphine [CYP2D22 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine CYP2D6 protein polymorphism affects the susceptibility to Codeine CYP2D6 protein results in decreased methylation of Codeine CYP2D6 gene polymorphism results in increased metabolism of Codeine; CYP2D6 protein results in increased metabolism of Codeine
CYP3A4 protein affects the metabolism of Codeine CYP3A4 protein results in increased metabolism of Codeine [CYP3A4 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine
Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased expression of BAX protein]; traxoprodil mesylate inhibits the reaction [Dextromethorphan results in increased expression of BAX protein]
Dextromethorphan results in decreased expression of BCL2L1 protein Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in decreased expression of BCL2L1 protein]; traxoprodil mesylate inhibits the reaction [Dextromethorphan results in decreased expression of BCL2L1 protein]
Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased cleavage of CASP3 protein]; traxoprodil mesylate inhibits the reaction [Dextromethorphan results in increased cleavage of CASP3 protein]
CYP2D2 protein results in decreased methylation of Dextromethorphan [CYP2D2 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan
CYP2D6 polymorphism affects the metabolism of Dextromethorphan; CYP2D6 protein affects the metabolism of Dextromethorphan; CYP2D6 protein polymorphism affects the metabolism of Dextromethorphan CYP2D6 protein results in decreased methylation of Dextromethorphan CYP2D6 mRNA results in increased metabolism of Dextromethorphan; CYP2D6 protein results in increased metabolism of Dextromethorphan [CYP2D22 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan; Ketoconazole inhibits the reaction [CYP2D22 protein results in increased metabolism of Dextromethorphan] Dextromethorphan results in decreased activity of CYP2D6 protein Cimetidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]; ozagrel promotes the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan] [5-bromotryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [5-chlorotryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [5-fluoro-alpha-methyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [5-fluoro-alpha-methyltryptamine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [5-fluorotryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [5-methyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [7-methyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [CYP2D6 mRNA results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan; [CYP2D6 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan; [Fluoxetine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [indopan analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [indopan results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [Methoxydimethyltryptamines analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [N,N-diisopropyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [Paroxetine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [Tryptamines analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; Nicardipine inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan]; notopterol inhibits the reaction [[CYP2D6 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan]; notopterol inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]; Paroxetine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]; Plant Extracts inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]; raubasine inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan]; Resveratrol inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]; sarpogrelate inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan]; sarpogrelate metabolite inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan]; serpentine (alkaloid) inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan] CYP2D6 gene polymorphism results in increased susceptibility to Dextromethorphan
CYP3A4 protein results in decreased methylation of Dextromethorphan CYP3A4 protein results in increased oxidation of Dextromethorphan CYP3A4 protein results in increased metabolism of Dextromethorphan Dextromethorphan inhibits the reaction [[retrorsine co-treated with NADP] results in decreased activity of CYP3A4 protein] CYP3A4 protein affects the metabolism of Dextromethorphan
CYP3A5 protein affects the metabolism of Dextromethorphan CYP3A5 protein results in increased oxidation of Dextromethorphan CYP3A5 protein results in decreased methylation of Dextromethorphan
Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]; Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased expression of FOS protein]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; traxoprodil mesylate inhibits the reaction [Dextromethorphan results in increased expression of FOS protein] Dextromethorphan inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of FOS]
Dextromethorphan affects the expression of GCLC mRNA PRKCD protein affects the reaction [Dextromethorphan affects the expression of GCLC mRNA]; rostafuroxin affects the reaction [Dextromethorphan affects the expression of GCLC mRNA]; rottlerin affects the reaction [Dextromethorphan affects the expression of GCLC mRNA]; traxoprodil mesylate affects the reaction [Dextromethorphan affects the expression of GCLC mRNA]
PRKCD protein affects the reaction [Dextromethorphan affects the expression of GCLM mRNA]; rostafuroxin affects the reaction [Dextromethorphan affects the expression of GCLM mRNA]; rottlerin affects the reaction [Dextromethorphan affects the expression of GCLM mRNA]; traxoprodil mesylate affects the reaction [Dextromethorphan affects the expression of GCLM mRNA]
Dextromethorphan inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in increased activity of GPT protein]
Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased expression of GRIN2B protein]; traxoprodil mesylate inhibits the reaction [Dextromethorphan results in increased expression of GRIN2B protein] Dextromethorphan promotes the reaction [PRKCD protein modified form binds to GRIN2B protein]; rostafuroxin inhibits the reaction [Dextromethorphan promotes the reaction [PRKCD protein modified form binds to GRIN2B protein]]; rostafuroxin inhibits the reaction [Dextromethorphan results in increased expression of GRIN2B protein]; rottlerin inhibits the reaction [Dextromethorphan promotes the reaction [PRKCD protein modified form binds to GRIN2B protein]]; traxoprodil mesylate inhibits the reaction [Dextromethorphan promotes the reaction [PRKCD protein modified form binds to GRIN2B protein]]; traxoprodil mesylate inhibits the reaction [Dextromethorphan results in increased expression of GRIN2B protein]
Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]] Dextromethorphan inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of JUN]
Dextromethorphan results in increased phosphorylation of MAPK1 protein rostafuroxin inhibits the reaction [Dextromethorphan results in increased phosphorylation of MAPK1 protein]
MRGPRX2 protein affects the susceptibility to Dextromethorphan MRGPRX2 protein affects the reaction [Dextromethorphan results in increased secretion of HEXB protein] Dextromethorphan binds to MRGPRX2 protein
[PRKCD protein affects the susceptibility to Dextromethorphan] which affects the activity of and affects the localization of NFE2L2 protein; [rostafuroxin co-treated with Dextromethorphan] results in increased activity of and affects the localization of NFE2L2 protein; [rottlerin co-treated with Dextromethorphan] results in increased activity of and affects the localization of NFE2L2 protein; [traxoprodil mesylate co-treated with Dextromethorphan] results in increased activity of and affects the localization of NFE2L2 protein; Buthionine Sulfoximine inhibits the reaction [Dextromethorphan results in increased activity of NFE2L2 protein]; Dextromethorphan results in increased activity of and affects the localization of NFE2L2 protein
[Dextromethorphan binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Dextromethorphan binds to OPRD1 protein] which results in decreased uptake of Serotonin
Dextromethorphan binds to OPRK1 protein [Dextromethorphan binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Dextromethorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin
[Dextromethorphan binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Dextromethorphan binds to OPRM1 protein] which results in decreased uptake of Serotonin
[PRKCD protein affects the susceptibility to Dextromethorphan] which affects the activity of and affects the localization of NFE2L2 protein; Dextromethorphan promotes the reaction [PRKCD protein modified form binds to GRIN2B protein]; Dextromethorphan results in increased expression of and results in increased phosphorylation of PRKCD protein; PRKCD protein affects the reaction [Dextromethorphan affects the expression of GCLC mRNA]; PRKCD protein affects the reaction [Dextromethorphan affects the expression of GCLM mRNA]; rostafuroxin inhibits the reaction [Dextromethorphan promotes the reaction [PRKCD protein modified form binds to GRIN2B protein]]; rostafuroxin inhibits the reaction [Dextromethorphan results in increased phosphorylation of PRKCD protein]; rottlerin inhibits the reaction [Dextromethorphan promotes the reaction [PRKCD protein modified form binds to GRIN2B protein]]; rottlerin inhibits the reaction [Dextromethorphan results in increased phosphorylation of PRKCD protein]; traxoprodil mesylate inhibits the reaction [Dextromethorphan promotes the reaction [PRKCD protein modified form binds to GRIN2B protein]]; traxoprodil mesylate inhibits the reaction [Dextromethorphan results in increased phosphorylation of PRKCD protein]
SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]] Dextromethorphan binds to SIGMAR1 protein
Dextromethorphan inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in increased activity of SORD protein]
Dextromethorphan results in decreased expression of TNF protein Dextromethorphan results in increased secretion of TNF protein Dextromethorphan inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in increased expression of TNF protein]; Dextromethorphan inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]
Diphenhydramine binds to and results in decreased activity of HRH1 protein; Diphenhydramine binds to and results in increased activity of HRH1 protein; Diphenhydramine inhibits the reaction [Pyrilamine binds to HRH1 protein]; HRH1 protein promotes the reaction [Diphenhydramine results in decreased susceptibility to CXCL8 protein] [Diphenhydramine results in decreased activity of HRH1 protein] which results in decreased susceptibility to Erythromycin
Diphenhydramine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Diphenhydramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
Diphenhydramine affects the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]; Diphenhydramine inhibits the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]
Aminoglutethimide inhibits the reaction [CYP19A1 protein affects the metabolism of Methadone]; formestane inhibits the reaction [CYP19A1 protein affects the metabolism of Methadone]
Methadone results in increased expression of IL4 mRNA; Methadone results in increased expression of IL4 protein CTAP octapeptide inhibits the reaction [Methadone results in increased expression of IL4 mRNA]; SB 203580 inhibits the reaction [Methadone results in increased expression of IL4 mRNA]
Methadone results in increased expression of IL6 mRNA; Methadone results in increased expression of IL6 protein Methadone results in increased secretion of IL6 protein
Methadone binds to OPRD1 protein [Methadone binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Methadone binds to OPRD1 protein] which results in decreased uptake of Serotonin
Methadone binds to OPRK1 protein [Methadone binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Methadone binds to OPRK1 protein] which results in decreased uptake of Serotonin
[Methadone binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Methadone binds to OPRM1 protein] which results in decreased uptake of Serotonin
Methadone affects the secretion of PRL protein Methadone results in increased secretion of PRL protein Methadone results in increased expression of PRL protein
Methadone binds to TLR4 protein Methadone results in increased expression of TLR4 mRNA; Methadone results in increased expression of TLR4 protein Methadone affects the susceptibility to TLR4 protein Naloxone affects the reaction [Methadone binds to TLR4 protein]
Oxycodone affects the expression of CYP2B2 mRNA Oxycodone results in increased expression of CYP2B2 mRNA; Oxycodone results in increased expression of CYP2B2 protein
CYP2D6 gene polymorphism affects the susceptibility to Oxycodone [Quinidine results in decreased activity of CYP2D6 protein] which affects the susceptibility to Oxycodone
Oxycodone inhibits the reaction [CYP3A2 protein results in increased hydroxylation of Testosterone] CYP3A4 protein alternative form affects the metabolism of Oxycodone telithromycin inhibits the reaction [CYP3A4 protein results in decreased methylation of Oxycodone] Oxycodone results in decreased expression of CYP3A2 mRNA; Oxycodone results in decreased expression of CYP3A2 protein
Tramadol affects the activity of CASP3 protein Tramadol results in decreased activity of CASP3 protein Vitamin E inhibits the reaction [Tramadol results in increased expression of CASP3 protein]
Tramadol results in decreased expression of CAT mRNA; Tramadol results in decreased expression of CAT protein Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of CAT mRNA]
Tramadol results in decreased expression of CKB mRNA Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein]
Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein]
CYP2D6 gene mutant form results in increased susceptibility to Tramadol CYP2D6 gene mutant form affects the metabolism of Tramadol; CYP2D6 gene polymorphism affects the metabolism of Tramadol CYP2D6 gene polymorphism results in decreased susceptibility to Tramadol CYP2D6 affects the susceptibility to Tramadol; CYP2D6 gene polymorphism affects the susceptibility to Tramadol; CYP2D6 protein affects the susceptibility to Tramadol [CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol] which results in increased chemical synthesis of O-demethyltramadol; CYP2D6 gene polymorphism affects the metabolism of and affects the susceptibility to Tramadol; CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol CYP2D6 protein results in decreased methylation of Tramadol CYP2D6 gene mutant form results in increased metabolism of Tramadol; CYP2D6 protein results in increased metabolism of Tramadol CYP2D6 protein affects the methylation of Tramadol
Tramadol results in increased activity of GPT protein Tramadol results in increased expression of GPT protein Vitamin E inhibits the reaction [Tramadol results in increased expression of GPT protein]
Tramadol binds to OPRD1 protein [Tramadol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRD1 protein] which results in decreased uptake of Serotonin
[Tramadol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRK1 protein] which results in decreased uptake of Serotonin
[Tramadol binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRM1 protein] which results in decreased uptake of Serotonin
Naloxone inhibits the reaction [Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]
Tramadol results in decreased expression of SOD1 mRNA; Tramadol results in decreased expression of SOD1 protein Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD1 mRNA]
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD2 mRNA] Tramadol results in decreased expression of SOD2 mRNA
Ethanol promotes the reaction [Tramadol results in increased expression of SPP1 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of SPP1 protein]
[Acetaminophen co-treated with Tramadol] inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNF protein]; Vitamin E inhibits the reaction [Tramadol results in increased expression of TNF protein]
Tramadol results in increased expression of TNNI3 protein Ethanol promotes the reaction [Tramadol results in increased expression of TNNI3 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNNI3 protein]
3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer results in increased phosphorylation of GRPR protein bisindolylmaleimide inhibits the reaction [3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer results in increased phosphorylation of GRPR protein]
3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to and results in increased activity of OPRK1 protein; [3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to and results in increased activity of OPRK1 protein] which results in increased phosphorylation of STAT3 protein 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer results in increased activity of OPRK1 protein OPRK1 protein affects the susceptibility to 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to and results in increased activity of OPRK1 protein; 7-hydroxymitragynine inhibits the reaction [3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to and results in increased activity of OPRK1 protein]; mitragynine inhibits the reaction [3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to and results in increased activity of OPRK1 protein]
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer affects the localization of PRKCD protein]
[3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to and results in increased activity of OPRK1 protein] which results in increased phosphorylation of STAT3 protein
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