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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:antitussive
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Accession:CHEBI:51177 term browser browse the term
Definition:An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.
Synonyms:related_synonym: anti-tussive;   cough suppressant;   cough suppressants


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(-)-noscapine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO Noscapine promotes the reaction [Cisplatin results in increased expression of BAX protein]
Noscapine results in increased expression of BAX protein
CTD PMID:20674069 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO Noscapine results in decreased expression of BCL2 protein
Noscapine promotes the reaction [Cisplatin results in decreased expression of BCL2 protein]
CTD PMID:20674069 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases response to substance
increases expression
decreases expression
multiple interactions
ISO BIRC5 protein results in decreased susceptibility to Noscapine
Noscapine results in increased expression of BIRC5 mRNA; Noscapine results in increased expression of BIRC5 protein
Noscapine results in decreased expression of BIRC5 protein
Noscapine promotes the reaction [Cisplatin results in decreased expression of BIRC5 protein]
CTD PMID:20674069 PMID:22848370 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO [Noscapine co-treated with Cisplatin] results in increased cleavage of CASP3 protein; Noscapine promotes the reaction [Cisplatin results in increased expression of and results in increased cleavage of CASP3 protein]; Noscapine results in increased expression of and results in increased cleavage of CASP3 protein
Noscapine results in increased activity of CASP3 protein
CTD PMID:20674069 PMID:22848370 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Noscapine promotes the reaction [Cisplatin results in increased expression of and results in increased cleavage of CASP9 protein]; Noscapine results in increased expression of and results in increased cleavage of CASP9 protein CTD PMID:20674069 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO Noscapine promotes the reaction [Cisplatin results in increased expression of CDKN1A protein]
Noscapine results in increased expression of CDKN1A protein
CTD PMID:20674069 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Noscapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:18493746 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO Noscapine results in increased degradation of and results in decreased expression of and results in decreased activity of HIF1A protein CTD PMID:16596621 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Noscapine results in increased cleavage of PARP1 protein CTD PMID:22848370 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Noscapine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO Noscapine promotes the reaction [Cisplatin results in increased expression of TP53 protein]; Noscapine results in increased expression of and results in increased phosphorylation of TP53 protein
Noscapine results in increased expression of TP53 protein
CTD PMID:20674069 PMID:22848370 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Vegfa vascular endothelial growth factor A decreases secretion ISO Noscapine results in decreased secretion of VEGFA protein CTD PMID:16596621 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
(E,E)-germacrone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO ABCB1 protein inhibits the reaction [germacrone results in increased susceptibility to Doxorubicin]; germacrone inhibits the reaction [Doxorubicin results in increased expression of ABCB1 mRNA]; germacrone inhibits the reaction [Doxorubicin results in increased expression of ABCB1 protein] CTD PMID:29655913 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [germacrone results in increased susceptibility to Doxorubicin] which results in increased expression of BAX CTD PMID:29655913 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [germacrone results in increased susceptibility to Doxorubicin] which results in decreased expression of BCL2 CTD PMID:29655913 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions ISO [germacrone results in increased susceptibility to Doxorubicin] which results in increased activity of CASP3 protein CTD PMID:29655913 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO germacrone results in decreased activity of CYP1A2 protein CTD PMID:23850985 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
decreases activity
ISO germacrone results in increased expression of CYP2B6 mRNA
germacrone results in decreased activity of CYP2B6 protein
CTD PMID:23850985 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO germacrone results in decreased activity of CYP2C19 protein CTD PMID:23850985 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO germacrone results in decreased activity of CYP2D6 protein CTD PMID:23850985 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
increases expression
ISO germacrone results in decreased activity of CYP3A4 protein
germacrone results in increased expression of CYP3A4 mRNA
CTD PMID:23850985 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO germacrone results in increased activity of NR1I2 protein CTD PMID:23850985 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO germacrone results in increased activity of NR1I3 protein CTD PMID:23850985 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
(R,R)-tramadol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A increases expression EXP Tramadol results in increased expression of ADRA1A protein CTD PMID:15464068 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP Tramadol results in increased expression of BAX protein CTD PMID:25550769 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bche butyrylcholinesterase decreases activity EXP Tramadol results in decreased activity of BCHE protein CTD PMID:28689766 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Casp3 caspase 3 affects activity
decreases activity
ISO
EXP
Tramadol affects the activity of CASP3 protein
Tramadol results in decreased activity of CASP3 protein
CTD PMID:27317026 PMID:28499616 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase decreases expression
multiple interactions
EXP Tramadol results in decreased expression of CAT mRNA
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of CAT mRNA]
CTD PMID:25550769 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ckb creatine kinase B decreases expression
multiple interactions
ISO
EXP
Tramadol results in decreased expression of CKB mRNA
Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein]
CTD PMID:27317026 PMID:33645892 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein] CTD PMID:33645892 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity ISO Tramadol results in decreased activity of CYP17A1 protein CTD PMID:29100959 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing
affects methylation
multiple interactions
decreases methylation
affects response to substance
decreases response to substance
increases response to substance
increases metabolic processing
ISO CYP2D6 gene mutant form affects the metabolism of Tramadol; CYP2D6 gene polymorphism affects the metabolism of Tramadol
CYP2D6 protein affects the methylation of Tramadol
[CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol] which results in increased chemical synthesis of O-demethyltramadol; CYP2D6 gene polymorphism affects the metabolism of and affects the susceptibility to Tramadol; CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol
CYP2D6 protein results in decreased methylation of Tramadol
CYP2D6 affects the susceptibility to Tramadol; CYP2D6 gene polymorphism affects the susceptibility to Tramadol; CYP2D6 protein affects the susceptibility to Tramadol
CYP2D6 gene polymorphism results in decreased susceptibility to Tramadol
CYP2D6 gene mutant form results in increased susceptibility to Tramadol
CYP2D6 gene mutant form results in increased metabolism of Tramadol; CYP2D6 protein results in increased metabolism of Tramadol
CTD PMID:12191703 PMID:12893130 PMID:14624403 PMID:16497087 PMID:16960721 More... NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Des desmin multiple interactions EXP Tramadol promotes the reaction [Ethanol results in increased expression of DES protein] CTD PMID:33645892 NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699
JBrowse link
G Drd2 dopamine receptor D2 increases expression EXP Tramadol results in increased expression of DRD2 protein CTD PMID:15464068 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Drd3 dopamine receptor D3 increases expression EXP Tramadol results in increased expression of DRD3 protein CTD PMID:15464068 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP Tramadol promotes the reaction [Ethanol results in increased expression of GJA1 protein] CTD PMID:33645892 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity EXP Tramadol results in increased activity of GPT protein CTD PMID:28689766 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A increases activity
increases expression
multiple interactions
EXP Tramadol results in increased activity of HTR2A protein
Tramadol results in increased expression of HTR2A mRNA
Ketanserin inhibits the reaction [Tramadol results in increased activity of HTR2A protein]
CTD PMID:18417104 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Ifng interferon gamma multiple interactions EXP Tramadol promotes the reaction [Ethanol results in increased expression of IFNG protein] CTD PMID:33645892 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Ldha lactate dehydrogenase A decreases expression ISO Tramadol results in decreased expression of LDHA mRNA CTD PMID:27317026 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 decreases expression ISO Tramadol results in decreased expression of NDUFS1 mRNA CTD PMID:27317026 NCBI chr 9:64,546,430...64,579,751
Ensembl chr 9:64,546,225...64,579,893
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding
multiple interactions
EXP Tramadol binds to OPRD1 protein
[Tramadol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRD1 protein] which results in decreased uptake of Serotonin
CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding
multiple interactions
EXP Tramadol binds to OPRK1 protein
[Tramadol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRK1 protein] which results in decreased uptake of Serotonin
CTD PMID:7562497 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprm1 opioid receptor, mu 1 affects binding
multiple interactions
EXP Tramadol binds to OPRM1 protein
[Tramadol binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRM1 protein] which results in decreased uptake of Serotonin
CTD PMID:7562497 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Pdk3 pyruvate dehydrogenase kinase 3 increases expression ISO Tramadol results in increased expression of PDK3 mRNA CTD PMID:27317026 NCBI chr  X:58,477,471...58,553,932
Ensembl chr  X:58,486,554...58,553,557
JBrowse link
G Pdyn prodynorphin decreases expression EXP Tramadol results in decreased expression of PDYN mRNA CTD PMID:17401159 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP Naloxone inhibits the reaction [Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein] CTD PMID:11723065 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Tramadol inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Tramadol inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression
multiple interactions
EXP Tramadol results in decreased expression of SOD1 mRNA
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD1 mRNA]
CTD PMID:25550769 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
decreases expression
EXP Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD2 mRNA]
Tramadol results in decreased expression of SOD2 mRNA
CTD PMID:25550769 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions
increases expression
EXP Ethanol promotes the reaction [Tramadol results in increased expression of SPP1 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of SPP1 protein] CTD PMID:33645892 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Acetaminophen co-treated with Tramadol] inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNF protein] CTD PMID:17377112 PMID:33645892 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions
increases expression
EXP Ethanol promotes the reaction [Tramadol results in increased expression of TNNI3 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNNI3 protein] CTD PMID:33645892 NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
JBrowse link
G Vim vimentin multiple interactions EXP Tramadol promotes the reaction [Ethanol results in increased expression of VIM protein] CTD PMID:33645892 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
(S)-glaucine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases activity ISO glaucine results in increased activity of ABCB1 protein CTD PMID:23273999 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
butorphanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oprd1 opioid receptor, delta 1 affects activity EXP Butorphanol affects the activity of OPRD1 protein CTD PMID:17909753 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects activity EXP Butorphanol affects the activity of OPRK1 protein CTD PMID:17909753 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprm1 opioid receptor, mu 1 affects activity
increases activity
ISO
EXP
Butorphanol affects the activity of OPRM1 protein
Butorphanol results in increased activity of OPRM1 protein
CTD PMID:17909753 PMID:32734307 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Prkcd protein kinase C, delta affects localization ISO Butorphanol affects the localization of PRKCD protein CTD PMID:29669290 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
clofedanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO clofedanol results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
codeine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 increases secretion ISO Codeine results in increased secretion of CCL2 protein CTD PMID:17441793 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Codeine affects the secretion of and affects the expression of CCL5 protein CTD PMID:17441793 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ces2h carboxylesterase 2H increases hydrolysis ISO CES2 protein results in increased hydrolysis of Codeine analog CTD PMID:25445008 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing
multiple interactions
increases metabolic processing
affects response to substance
decreases methylation
ISO CYP2D6 protein affects the metabolism of Codeine; CYP2D6 protein polymorphism affects the metabolism of Codeine
[CYP2D6 gene mutant form results in increased activity of CYP2D6 protein] which results in increased susceptibility to Codeine; [CYP2D6 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of Morphine
[CYP2D22 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine
CYP2D6 protein polymorphism affects the susceptibility to Codeine
CYP2D6 protein results in decreased methylation of Codeine
CYP2D6 gene polymorphism results in increased metabolism of Codeine; CYP2D6 protein results in increased metabolism of Codeine
CTD PMID:9696456 PMID:10911933 PMID:11823760 PMID:15286053 PMID:15625333 More... NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing
increases metabolic processing
multiple interactions
ISO CYP3A4 protein affects the metabolism of Codeine
CYP3A4 protein results in increased metabolism of Codeine
[CYP3A4 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine
CTD PMID:15286053 PMID:16595712 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Codeine results in decreased activity of KCNH2 protein CTD PMID:19034038 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding EXP Codeine binds to OPRD1 protein CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding EXP Codeine binds to OPRK1 protein CTD PMID:7562497 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprm1 opioid receptor, mu 1 affects binding EXP Codeine binds to OPRM1 protein CTD PMID:7562497 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
dextromethorphan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
EXP Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased expression of BAX protein]; traxoprodil mesylate inhibits the reaction [Dextromethorphan results in increased expression of BAX protein] CTD PMID:28916251 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
EXP traxoprodil mesylate inhibits the reaction [Dextromethorphan results in decreased expression of BCL2 protein] CTD PMID:28916251 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions
EXP Dextromethorphan results in decreased expression of BCL2L1 protein
Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in decreased expression of BCL2L1 protein]; traxoprodil mesylate inhibits the reaction [Dextromethorphan results in decreased expression of BCL2L1 protein]
CTD PMID:28916251 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
EXP Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased cleavage of CASP3 protein]; traxoprodil mesylate inhibits the reaction [Dextromethorphan results in increased cleavage of CASP3 protein] CTD PMID:28916251 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
increases secretion
ISO Dextromethorphan results in decreased expression of CCL2 protein
Dextromethorphan results in increased secretion of CCL2 protein
CTD PMID:19189960 PMID:32871113 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Dextromethorphan results in decreased activity of CYP1A1 protein CTD PMID:18420780 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing ISO CYP1A2 protein affects the metabolism of Dextromethorphan CTD PMID:15199075 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Dextromethorphan results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity ISO Dextromethorphan results in decreased activity of CYP2B10 protein CTD PMID:18420780 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 affects metabolic processing EXP CYP2C13 protein affects the metabolism of Dextromethorphan CTD PMID:15879494 NCBI chr 1:238,786,764...238,867,195
Ensembl chr 1:238,786,765...238,867,191
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 affects metabolic processing ISO CYP2C19 protein affects the metabolism of Dextromethorphan CTD PMID:15286053 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2d1 cytochrome P450, family 2, subfamily d, polypeptide 1 increases metabolic processing
multiple interactions
ISO CYP2D10 protein results in increased metabolism of Dextromethorphan
[CYP2D10 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan
CTD PMID:30503582 NCBI chr 7:113,908,950...113,913,420 JBrowse link
G Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 decreases methylation
multiple interactions
increases metabolic processing
EXP CYP2D2 protein results in decreased methylation of Dextromethorphan
[CYP2D2 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan
CTD PMID:11911841 PMID:28438436 NCBI chr 7:113,935,138...113,939,209
Ensembl chr 7:113,935,138...113,939,209
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing
decreases methylation
increases metabolic processing
multiple interactions
decreases activity
increases response to substance
ISO
EXP
CYP2D6 polymorphism affects the metabolism of Dextromethorphan; CYP2D6 protein affects the metabolism of Dextromethorphan; CYP2D6 protein polymorphism affects the metabolism of Dextromethorphan
CYP2D6 protein results in decreased methylation of Dextromethorphan
CYP2D6 mRNA results in increased metabolism of Dextromethorphan; CYP2D6 protein results in increased metabolism of Dextromethorphan
[CYP2D22 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan; Ketoconazole inhibits the reaction [CYP2D22 protein results in increased metabolism of Dextromethorphan]
Dextromethorphan results in decreased activity of CYP2D6 protein
Cimetidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]; ozagrel promotes the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]
[5-bromotryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [5-chlorotryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [5-fluoro-alpha-methyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [5-fluoro-alpha-methyltryptamine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [5-fluorotryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [5-methyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [7-methyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [CYP2D6 mRNA results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan; [CYP2D6 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan; [Fluoxetine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [indopan analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [indopan results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [Methoxydimethyltryptamines analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [N,N-diisopropyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [Paroxetine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [Tryptamines analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; Nicardipine inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan]; notopterol inhibits the reaction [[CYP2D6 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan]; notopterol inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]; Paroxetine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]; Plant Extracts inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]; raubasine inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan]; Resveratrol inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]; sarpogrelate inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan]; sarpogrelate metabolite inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan]; serpentine (alkaloid) inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan]
CYP2D6 gene polymorphism results in increased susceptibility to Dextromethorphan
CTD PMID:9429230 PMID:9429232 PMID:10911933 PMID:11823760 PMID:12433797 More... NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Dextromethorphan results in decreased activity of CYP2E1 protein CTD PMID:18420780 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases methylation
increases oxidation
increases metabolic processing
multiple interactions
affects metabolic processing
ISO CYP3A4 protein results in decreased methylation of Dextromethorphan
CYP3A4 protein results in increased oxidation of Dextromethorphan
CYP3A4 protein results in increased metabolism of Dextromethorphan
Dextromethorphan inhibits the reaction [[retrorsine co-treated with NADP] results in decreased activity of CYP3A4 protein]
CYP3A4 protein affects the metabolism of Dextromethorphan
CTD PMID:15383492 PMID:15988119 PMID:16595712 PMID:17267297 PMID:19818743 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 affects metabolic processing EXP CYP3A23-3A1 protein affects the metabolism of Dextromethorphan CTD PMID:15879494 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects metabolic processing
increases oxidation
decreases methylation
ISO CYP3A5 protein affects the metabolism of Dextromethorphan
CYP3A5 protein results in increased oxidation of Dextromethorphan
CYP3A5 protein results in decreased methylation of Dextromethorphan
CTD PMID:15383492 PMID:15988119 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 decreases methylation ISO CYP46A1 protein results in decreased methylation of Dextromethorphan CTD PMID:14640697 NCBI chr 6:127,243,315...127,274,765
Ensembl chr 6:127,243,315...127,274,760
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP
ISO
Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]; Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased expression of FOS protein]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; traxoprodil mesylate inhibits the reaction [Dextromethorphan results in increased expression of FOS protein]
Dextromethorphan inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of FOS]
CTD PMID:15084442 PMID:15723099 PMID:28916251 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Dextromethorphan inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in increased activity of GPT protein] CTD PMID:30822415 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 increases expression EXP Dextromethorphan results in increased expression of GRIN1 protein CTD PMID:28916251 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A increases expression EXP Dextromethorphan results in increased expression of GRIN2A protein CTD PMID:28916251 NCBI chr10:5,630,684...6,043,341
Ensembl chr10:5,631,369...6,044,637
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions
increases expression
EXP Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased expression of GRIN2B protein]; traxoprodil mesylate inhibits the reaction [Dextromethorphan results in increased expression of GRIN2B protein] CTD PMID:28916251 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
JBrowse link
G Hexb hexosaminidase subunit beta multiple interactions
increases secretion
ISO MRGPRX2 protein affects the reaction [Dextromethorphan results in increased secretion of HEXB protein] CTD PMID:32871113 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223
JBrowse link
G Il10 interleukin 10 decreases expression ISO Dextromethorphan results in decreased expression of IL10 protein CTD PMID:19189960 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il6 interleukin 6 decreases expression ISO Dextromethorphan results in decreased expression of IL6 protein CTD PMID:19189960 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP
ISO
Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]
Dextromethorphan inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of JUN]
CTD PMID:15084442 PMID:15723099 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Dextromethorphan results in decreased activity of KCNH2 protein CTD PMID:19034038 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase affects response to substance ISO KIT protein affects the susceptibility to Dextromethorphan CTD PMID:32871113 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
JBrowse link
G Mrgprx2 MAS related GPR family member X2 affects response to substance
multiple interactions
affects binding
ISO MRGPRX2 protein affects the susceptibility to Dextromethorphan
MRGPRX2 protein affects the reaction [Dextromethorphan results in increased secretion of HEXB protein]
Dextromethorphan binds to MRGPRX2 protein
CTD PMID:32871113 NCBI chr 1:98,116,192...98,135,534 JBrowse link
G Nat2 N-acetyltransferase 2 affects metabolic processing ISO NAT2 protein affects the metabolism of Dextromethorphan CTD PMID:15199075 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Oprd1 opioid receptor, delta 1 multiple interactions
affects binding
EXP [Dextromethorphan binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Dextromethorphan binds to OPRD1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding
multiple interactions
EXP Dextromethorphan binds to OPRK1 protein
[Dextromethorphan binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Dextromethorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin
CTD PMID:7562497 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding
EXP [Dextromethorphan binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Dextromethorphan binds to OPRM1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Dextromethorphan inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:15987631 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Sigmar1 sigma non-opioid intracellular receptor 1 multiple interactions
affects binding
EXP SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]
Dextromethorphan binds to SIGMAR1 protein
CTD PMID:15723099 NCBI chr 5:56,904,155...56,907,012
Ensembl chr 5:56,904,159...56,907,017
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Dextromethorphan inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions EXP Dextromethorphan inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of SLC6A4 protein] CTD PMID:31153898 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
JBrowse link
G Sord sorbitol dehydrogenase multiple interactions ISO Dextromethorphan inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in increased activity of SORD protein] CTD PMID:30822415 NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133
JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO Dextromethorphan inhibits the reaction [Lipopolysaccharides results in increased secretion of TGFA] CTD PMID:15987631 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
JBrowse link
G Tnf tumor necrosis factor decreases expression
increases secretion
multiple interactions
ISO Dextromethorphan results in decreased expression of TNF protein
Dextromethorphan results in increased secretion of TNF protein
Dextromethorphan inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in increased expression of TNF protein]; Dextromethorphan inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]
CTD PMID:19189960 PMID:30822415 PMID:32871113 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Xdh xanthine dehydrogenase affects metabolic processing ISO XDH protein affects the metabolism of Dextromethorphan CTD PMID:15199075 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link
dimenhydrinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase decreases activity ISO Dimenhydrinate results in decreased activity of BCHE protein CTD PMID:236606 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Dimenhydrinate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
diphenhydramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg5 autophagy related 5 affects response to substance ISO ATG5 protein affects the susceptibility to Diphenhydramine CTD PMID:22310178 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Bche butyrylcholinesterase multiple interactions
decreases activity
ISO Protons affects the reaction [Diphenhydramine results in decreased activity of BCHE protein] CTD PMID:236606 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Bmp6 bone morphogenetic protein 6 decreases expression ISO Diphenhydramine results in decreased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr17:26,318,121...26,469,034
Ensembl chr17:26,318,569...26,470,365
JBrowse link
G Ereg epiregulin decreases expression ISO Diphenhydramine results in decreased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Diphenhydramine inhibits the reaction [Histamine results in increased expression of F3] CTD PMID:16009787 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Gnai1 G protein subunit alpha i1 increases response to substance ISO GNAI1 results in increased susceptibility to Diphenhydramine CTD PMID:14614911 NCBI chr 4:16,813,941...16,898,111
Ensembl chr 4:16,814,001...16,896,417
JBrowse link
G Gnai2 G protein subunit alpha i2 increases response to substance ISO GNAI2 results in increased susceptibility to Diphenhydramine CTD PMID:14614911 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions ISO
EXP
Diphenhydramine binds to and results in decreased activity of HRH1 protein; Diphenhydramine binds to and results in increased activity of HRH1 protein; Diphenhydramine inhibits the reaction [Pyrilamine binds to HRH1 protein]; HRH1 protein promotes the reaction [Diphenhydramine results in decreased susceptibility to CXCL8 protein]
[Diphenhydramine results in decreased activity of HRH1 protein] which results in decreased susceptibility to Erythromycin
CTD PMID:1912125 PMID:2419744 PMID:2461127 PMID:7522859 PMID:9609743 More... NCBI chr 4:147,564,781...147,649,353
Ensembl chr 4:147,645,995...147,647,455
JBrowse link
G Il1b interleukin 1 beta increases expression
decreases expression
ISO Diphenhydramine results in increased expression of IL1B mRNA
Diphenhydramine results in decreased expression of IL1B mRNA
CTD PMID:28138970 PMID:32816093 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il24 interleukin 24 decreases expression ISO Diphenhydramine results in decreased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Diphenhydramine inhibits the reaction [Histamine results in increased expression of IL6 protein] CTD PMID:11336536 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases activity ISO Diphenhydramine results in increased activity of MAPK8 CTD PMID:17390763 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO [Diphenhydramine co-treated with PK 11195] binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Pla2g4a phospholipase A2 group IVA multiple interactions ISO Diphenhydramine inhibits the reaction [Histamine results in increased expression of PLA2G4A mRNA] CTD PMID:9609743 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Diphenhydramine results in decreased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Diphenhydramine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium] CTD PMID:16263091 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Diphenhydramine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Diphenhydramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:16263091 PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO Diphenhydramine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium] CTD PMID:16263091 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO Diphenhydramine affects the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]; Diphenhydramine inhibits the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine] CTD PMID:19821448 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO Diphenhydramine results in decreased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Diphenhydramine results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
doxylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Doxylamine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Doxylamine binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
hydrocodone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oprd1 opioid receptor, delta 1 affects binding EXP Hydrocodone binds to OPRD1 protein CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding EXP Hydrocodone binds to OPRK1 protein CTD PMID:7562497 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprm1 opioid receptor, mu 1 affects binding EXP Hydrocodone binds to OPRM1 protein CTD PMID:7562497 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
methadone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
affects activity
ISO Methadone results in increased expression of ABCB1 protein
Methadone affects the activity of ABCB1 protein
CTD PMID:19840843 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects activity
increases expression
EXP Methadone affects the activity of ABCB1B protein
Methadone results in increased expression of ABCB1B protein
CTD PMID:19840843 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects localization ISO Methadone affects the localization of BAX protein CTD PMID:20691259 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases secretion EXP Methadone results in increased secretion of CCL2 protein CTD PMID:20178837 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases secretion EXP Methadone results in increased secretion of CCL3 protein CTD PMID:20178837 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 increases secretion EXP Methadone results in increased secretion of CX3CL1 protein CTD PMID:20178837 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases secretion EXP Methadone results in increased secretion of CXCL1 protein CTD PMID:20178837 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cycs cytochrome c, somatic affects localization ISO Methadone affects the localization of CYCS protein CTD PMID:20691259 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
affects metabolic processing
ISO Aminoglutethimide inhibits the reaction [CYP19A1 protein affects the metabolism of Methadone]; formestane inhibits the reaction [CYP19A1 protein affects the metabolism of Methadone] CTD PMID:15242824 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
decreases activity
ISO CYP2D22 protein results in increased metabolism of Methadone
Methadone results in decreased activity of CYP2D6 protein
CTD PMID:16595712 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing
increases metabolic processing
ISO CYP3A4 protein affects the metabolism of Methadone
CYP3A4 protein results in increased metabolism of Methadone
CTD PMID:15986265 PMID:16595712 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP Methadone affects the reaction [Cocaine affects the expression of DRD2 mRNA] CTD PMID:18990547 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Hcrt hypocretin neuropeptide precursor multiple interactions EXP Methadone affects the reaction [Cocaine affects the expression of HCRT mRNA] CTD PMID:18990547 NCBI chr10:85,689,992...85,691,206
Ensembl chr10:85,689,465...85,691,210
JBrowse link
G Il10 interleukin 10 increases secretion EXP Methadone results in increased secretion of IL10 protein CTD PMID:20178837 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1a interleukin 1 alpha increases expression EXP Methadone results in increased expression of IL1A protein CTD PMID:20178837 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta increases secretion
increases expression
EXP Methadone results in increased secretion of IL1B protein
Methadone results in increased expression of IL1B protein
CTD PMID:20178837 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 decreases expression ISO Methadone results in decreased expression of IL2 mRNA CTD PMID:23965172 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 increases expression
multiple interactions
ISO Methadone results in increased expression of IL4 mRNA; Methadone results in increased expression of IL4 protein
CTAP octapeptide inhibits the reaction [Methadone results in increased expression of IL4 mRNA]; SB 203580 inhibits the reaction [Methadone results in increased expression of IL4 mRNA]
CTD PMID:23965172 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 increases expression
increases secretion
EXP Methadone results in increased expression of IL6 mRNA; Methadone results in increased expression of IL6 protein
Methadone results in increased secretion of IL6 protein
CTD PMID:20178837 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins2 insulin 2 decreases response to substance ISO Methadone results in decreased susceptibility to INS protein CTD PMID:2554359 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
ISO Chlorobutanol promotes the reaction [Methadone results in decreased activity of KCNH2 protein] CTD PMID:14527710 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Lep leptin increases expression ISO Methadone results in increased expression of LEP protein CTD PMID:15717844 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Methadone results in increased phosphorylation of MAPK1 protein CTD PMID:23965172 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Methadone results in increased phosphorylation of MAPK3 protein CTD PMID:23965172 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO Methadone results in increased expression of NFKBIA protein CTD PMID:22258905 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding
multiple interactions
EXP Methadone binds to OPRD1 protein
[Methadone binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Methadone binds to OPRD1 protein] which results in decreased uptake of Serotonin
CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding
multiple interactions
EXP Methadone binds to OPRK1 protein
[Methadone binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Methadone binds to OPRK1 protein] which results in decreased uptake of Serotonin
CTD PMID:7562497 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding
EXP [Methadone binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Methadone binds to OPRM1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Pld2 phospholipase D2 increases activity ISO Methadone results in increased activity of PLD2 protein CTD PMID:23965172 NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808
JBrowse link
G Prl prolactin affects secretion
increases secretion
increases expression
ISO Methadone affects the secretion of PRL protein
Methadone results in increased secretion of PRL protein
Methadone results in increased expression of PRL protein
CTD PMID:2554359 PMID:16675813 PMID:21094671 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Tlr4 toll-like receptor 4 affects binding
increases expression
affects response to substance
multiple interactions
ISO
EXP
Methadone binds to TLR4 protein
Methadone results in increased expression of TLR4 mRNA; Methadone results in increased expression of TLR4 protein
Methadone affects the susceptibility to TLR4 protein
Naloxone affects the reaction [Methadone binds to TLR4 protein]
CTD PMID:20178837 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor increases secretion
increases expression
EXP Methadone results in increased secretion of TNF protein
Methadone results in increased expression of TNF protein
CTD PMID:20178837 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
norcodeine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO [CYP2D22 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine CTD PMID:16595712 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine CTD PMID:16595712 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
oxycodone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca8 ATP binding cassette subfamily A member 8 increases expression EXP Oxycodone results in increased expression of ABCA8 mRNA CTD PMID:23439660 NCBI chr10:94,917,520...94,991,199
Ensembl chr10:94,917,520...94,990,988
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression EXP Oxycodone results in increased expression of ABCB1A mRNA; Oxycodone results in increased expression of ABCB1A protein CTD PMID:23439660 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 increases expression EXP Oxycodone results in increased expression of ABCB4 mRNA CTD PMID:23439660 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 decreases expression EXP Oxycodone results in decreased expression of ABCG1 mRNA CTD PMID:23439660 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression EXP Oxycodone results in increased expression of ABCG5 mRNA CTD PMID:23439660 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
JBrowse link
G Abhd6 abhydrolase domain containing 6, acylglycerol lipase increases expression EXP Oxycodone results in increased expression of ABHD6 mRNA CTD PMID:23439660 NCBI chr15:16,859,740...16,907,094
Ensembl chr15:16,859,738...16,906,985
JBrowse link
G Acsm2 acyl-CoA synthetase medium-chain family member 2 increases expression EXP Oxycodone results in increased expression of ACSM2A mRNA CTD PMID:23439660 NCBI chr 1:173,916,368...173,955,116
Ensembl chr 1:173,916,368...173,955,116
JBrowse link
G Actn1 actinin, alpha 1 decreases expression EXP Oxycodone results in decreased expression of ACTN1 mRNA CTD PMID:23439660 NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 decreases expression EXP Oxycodone results in decreased expression of ADAM17 mRNA CTD PMID:23439660 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639
JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 increases expression EXP Oxycodone results in increased expression of ADAMTS1 mRNA CTD PMID:23439660 NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103
JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 decreases expression EXP Oxycodone results in decreased expression of ADGRE1 mRNA CTD PMID:23439660 NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000
JBrowse link
G Ahr aryl hydrocarbon receptor increases expression EXP Oxycodone results in increased expression of AHR mRNA CTD PMID:23439660 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases expression EXP Oxycodone results in decreased expression of AKR1C3 mRNA CTD PMID:23439660 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Anxa3 annexin A3 decreases expression EXP Oxycodone results in decreased expression of ANXA3 mRNA CTD PMID:23439660 NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617
JBrowse link
G Arhgdib Rho GDP dissociation inhibitor beta decreases expression EXP Oxycodone results in decreased expression of ARHGDIB mRNA CTD PMID:23439660 NCBI chr 4:169,822,951...169,841,884
Ensembl chr 4:169,822,952...169,841,658
JBrowse link
G Asl argininosuccinate lyase increases expression EXP Oxycodone results in increased expression of ASL mRNA CTD PMID:23439660 NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO
EXP
Oxycodone results in increased expression of ATF4 protein CTD PMID:26377394 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 increases expression EXP Oxycodone results in increased expression of ATP1B1 mRNA CTD PMID:23439660 NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459
JBrowse link
G B4galnt1 beta-1,4-N-acetyl-galactosaminyl transferase 1 increases expression EXP Oxycodone results in increased expression of B4GALNT1 mRNA CTD PMID:23439660 NCBI chr 7:62,988,429...62,996,190
Ensembl chr 7:62,988,930...62,996,190
JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression EXP Oxycodone results in decreased expression of BCL2A1 mRNA CTD PMID:23439660 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
JBrowse link
G Blvra biliverdin reductase A decreases expression EXP Oxycodone results in decreased expression of BLVRA mRNA CTD PMID:23439660 NCBI chr 3:114,340,778...114,366,048
Ensembl chr 3:114,340,838...114,366,033
JBrowse link
G Ca3 carbonic anhydrase 3 decreases expression EXP Oxycodone results in decreased expression of CA3 mRNA CTD PMID:23439660 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
JBrowse link
G Cav2 caveolin 2 decreases expression EXP Oxycodone results in decreased expression of CAV2 mRNA CTD PMID:23439660 NCBI chr 4:45,616,766...45,624,144
Ensembl chr 4:45,616,712...45,624,244
JBrowse link
G Ccl6 C-C motif chemokine ligand 6 decreases expression EXP Oxycodone results in decreased expression of CCL6 mRNA CTD PMID:23439660 NCBI chr10:68,381,179...68,385,811
Ensembl chr10:68,380,188...68,384,001
JBrowse link
G Cd5l Cd5 molecule-like decreases expression EXP Oxycodone results in decreased expression of CD5L mRNA CTD PMID:23439660 NCBI chr 2:172,791,007...172,802,018 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP Oxycodone results in increased expression of CDKN1A mRNA CTD PMID:23439660 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Ces2h carboxylesterase 2H affects expression
increases expression
EXP Oxycodone affects the expression of CES2 mRNA
Oxycodone results in increased expression of CES2 mRNA
CTD PMID:20487198 PMID:23439660 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Chd1l chromodomain helicase DNA binding protein 1-like increases expression EXP Oxycodone results in increased expression of CHD1L mRNA CTD PMID:23439660 NCBI chr 2:185,138,526...185,217,498
Ensembl chr 2:185,139,308...185,217,595
JBrowse link
G Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 decreases expression EXP Oxycodone results in decreased expression of CMTM6 mRNA CTD PMID:23439660 NCBI chr 8:114,422,681...114,441,034
Ensembl chr 8:114,422,921...114,441,033
JBrowse link
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase decreases expression EXP Oxycodone results in decreased expression of CNP1 mRNA CTD PMID:23439660 NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720
JBrowse link
G Cotl1 coactosin-like F-actin binding protein 1 decreases expression EXP Oxycodone results in decreased expression of COTL1 mRNA CTD PMID:23439660 NCBI chr19:47,871,689...47,906,010
Ensembl chr19:47,871,694...47,911,689
JBrowse link
G Csrp1 cysteine and glycine-rich protein 1 decreases expression EXP Oxycodone results in decreased expression of CSRP1 mRNA CTD PMID:23439660 NCBI chr13:47,158,171...47,179,388
Ensembl chr13:47,167,789...47,179,384
JBrowse link
G Ctsc cathepsin C decreases expression EXP Oxycodone results in decreased expression of CTSC mRNA CTD PMID:23439660 NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387
JBrowse link
G Ctsl cathepsin L increases expression EXP Oxycodone results in increased expression of CTSL mRNA CTD PMID:23439660 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
JBrowse link
G Cyba cytochrome b-245 alpha chain decreases expression EXP Oxycodone results in decreased expression of CYBA mRNA CTD PMID:23439660 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 affects expression
increases expression
EXP Oxycodone affects the expression of CYP17A1 mRNA
Oxycodone results in increased expression of CYP17A1 mRNA
CTD PMID:20487198 PMID:23439660 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases expression EXP Oxycodone results in increased expression of CYP27A1 mRNA CTD PMID:23439660 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 increases expression EXP Oxycodone results in increased expression of CYP2A1 mRNA CTD PMID:23439660 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 affects expression
increases expression
EXP Oxycodone affects the expression of CYP2B2 mRNA
Oxycodone results in increased expression of CYP2B2 mRNA; Oxycodone results in increased expression of CYP2B2 protein
CTD PMID:20487198 PMID:23439660 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression EXP Oxycodone results in decreased expression of CYP2C11 mRNA CTD PMID:23439660 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 affects expression
decreases expression
EXP Oxycodone affects the expression of CYP2C13 mRNA
Oxycodone results in decreased expression of CYP2C13 mRNA
CTD PMID:20487198 PMID:23439660 NCBI chr 1:238,786,764...238,867,195
Ensembl chr 1:238,786,765...238,867,191
JBrowse link
G Cyp2c7 cytochrome P450, family 2, subfamily c, polypeptide 7 decreases expression EXP Oxycodone results in decreased expression of CYP2C9 mRNA CTD PMID:23439660 NCBI chr 1:237,332,641...237,388,714
Ensembl chr 1:237,332,659...237,388,709
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects response to substance
multiple interactions
ISO CYP2D6 gene polymorphism affects the susceptibility to Oxycodone
[Quinidine results in decreased activity of CYP2D6 protein] which affects the susceptibility to Oxycodone
CTD PMID:20590588 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression EXP Oxycodone results in increased expression of CYP2E1 mRNA CTD PMID:23439660 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 increases expression EXP Oxycodone results in increased expression of CYP2J4 mRNA CTD PMID:23439660 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
affects metabolic processing
decreases expression
EXP
ISO
Oxycodone inhibits the reaction [CYP3A2 protein results in increased hydroxylation of Testosterone]
CYP3A4 protein alternative form affects the metabolism of Oxycodone
telithromycin inhibits the reaction [CYP3A4 protein results in decreased methylation of Oxycodone]
Oxycodone results in decreased expression of CYP3A2 mRNA; Oxycodone results in decreased expression of CYP3A2 protein
CTD PMID:19755414 PMID:20487198 PMID:33393779 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Oxycodone results in increased expression of CYP3A23-3A1 mRNA; Oxycodone results in increased expression of CYP3A23-3A1 protein CTD PMID:23439660 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 increases expression EXP Oxycodone results in increased expression of CYP4B1 mRNA CTD PMID:23439660 NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348
JBrowse link
G Dbt dihydrolipoamide branched chain transacylase E2 increases expression EXP Oxycodone results in increased expression of DBT mRNA CTD PMID:23439660 NCBI chr 2:204,481,744...204,510,612
Ensembl chr 2:204,481,737...204,510,609
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression EXP Oxycodone results in increased expression of EHHADH mRNA CTD PMID:23439660 NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions
increases phosphorylation
ISO
EXP
Naloxone inhibits the reaction [Oxycodone results in increased phosphorylation of EIF2S1 protein] CTD PMID:26377394 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Ell2 elongation factor for RNA polymerase II 2 increases expression EXP Oxycodone results in increased expression of ELL2 mRNA CTD PMID:23439660 NCBI chr 2:5,189,375...5,258,781
Ensembl chr 2:5,189,971...5,258,781
JBrowse link
G Ephx2 epoxide hydrolase 2 affects expression EXP Oxycodone affects the expression of EPHX2 mRNA CTD PMID:20487198 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
JBrowse link
G Exosc5 exosome component 5 increases expression EXP Oxycodone results in increased expression of EXOSC5 mRNA CTD PMID:23439660 NCBI chr 1:81,168,128...81,177,266
Ensembl chr 1:81,166,023...81,177,265
JBrowse link
G Fcgr2a Fc fragment of IgG receptor IIa decreases expression EXP Oxycodone results in decreased expression of FCGR2A mRNA CTD PMID:23439660 NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 increases expression EXP Oxycodone results in increased expression of FKBP5 mRNA CTD PMID:23439660 NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 affects expression
increases expression
EXP Oxycodone affects the expression of FMO1 mRNA
Oxycodone results in increased expression of FMO1 mRNA
CTD PMID:20487198 PMID:23439660 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Oxycodone results in increased expression of FOS protein CTD PMID:26377394 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial increases expression EXP Oxycodone results in increased expression of GPAM mRNA CTD PMID:23439660 NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression EXP Oxycodone results in increased expression of GPT mRNA CTD PMID:23439660 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpt2 glutamic--pyruvic transaminase 2 increases expression EXP Oxycodone results in increased expression of GPT2 mRNA CTD PMID:23439660 NCBI chr19:21,526,800...21,561,314
Ensembl chr19:21,517,621...21,560,610
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases expression EXP Oxycodone results in increased expression of GSTA3 mRNA CTD PMID:23439660 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression EXP Oxycodone results in increased expression of GSTA5 mRNA; Oxycodone results in increased expression of GSTA5 protein CTD PMID:20487198 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
JBrowse link
G Hacl1 2-hydroxyacyl-CoA lyase 1 increases expression EXP Oxycodone results in increased expression of HACL1 mRNA CTD PMID:23439660 NCBI chr16:6,826,881...6,863,027
Ensembl chr16:6,824,906...6,863,027
JBrowse link
G Hao2 hydroxyacid oxidase 2 decreases expression EXP Oxycodone results in decreased expression of HAO2 mRNA CTD PMID:23439660 NCBI chr 2:186,200,137...186,232,997
Ensembl chr 2:186,200,504...186,224,425
JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase decreases expression EXP Oxycodone results in decreased expression of HCK mRNA CTD PMID:23439660 NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693
JBrowse link
G Hexb hexosaminidase subunit beta increases expression EXP Oxycodone results in increased expression of HEXB mRNA CTD PMID:23439660 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223
JBrowse link
G Hnrnpab heterogeneous nuclear ribonucleoprotein A/B increases expression EXP Oxycodone results in increased expression of HNRNPAB mRNA CTD PMID:23439660 NCBI chr10:35,857,040...35,862,935
Ensembl chr10:35,857,041...35,863,344
JBrowse link
G Homer1 homer scaffold protein 1 increases expression EXP Oxycodone results in increased expression of HOMER1 mRNA CTD PMID:23439660 NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases expression EXP Oxycodone results in decreased expression of HSD11B1 mRNA CTD PMID:23439660 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO
EXP
Oxycodone results in increased expression of HSPA5 protein CTD PMID:26377394 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Igfals insulin-like growth factor binding protein, acid labile subunit decreases expression EXP Oxycodone results in decreased expression of IGFALS mRNA CTD PMID:23439660 NCBI chr10:13,897,468...13,903,920
Ensembl chr10:13,898,395...13,902,677
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression EXP Oxycodone results in increased expression of IGFBP1 mRNA CTD PMID:23439660 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
JBrowse link
G Il18bp interleukin 18 binding protein decreases expression EXP Oxycodone results in decreased expression of IL18BP mRNA CTD PMID:23439660 NCBI chr 1:156,372,923...156,374,963
Ensembl chr 1:156,372,883...156,374,963
JBrowse link
G Inhbe inhibin subunit beta E decreases expression EXP Oxycodone results in decreased expression of INHBE mRNA CTD PMID:23439660 NCBI chr 7:63,177,558...63,178,983
Ensembl chr 7:63,176,219...63,179,172
JBrowse link
G Ip6k2 inositol hexakisphosphate kinase 2 increases expression EXP Oxycodone results in increased expression of IP6K2 mRNA CTD PMID:23439660 NCBI chr 8:109,483,843...109,510,172
Ensembl chr 8:109,484,310...109,510,166
JBrowse link
G Itgb2 integrin subunit beta 2 decreases expression EXP Oxycodone results in decreased expression of ITGB2 mRNA CTD PMID:23439660 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 increases expression EXP Oxycodone results in increased expression of ITPR1 mRNA CTD PMID:23439660 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
JBrowse link
G Jchain joining chain of multimeric IgA and IgM decreases expression EXP Oxycodone results in decreased expression of JCHAIN mRNA CTD PMID:23439660 NCBI chr14:19,538,560...19,546,384
Ensembl chr14:19,538,952...19,546,298
JBrowse link
G Klc4 kinesin light chain 4 increases expression EXP Oxycodone results in increased expression of KLC4 mRNA CTD PMID:23439660 NCBI chr 9:14,337,164...14,351,075
Ensembl chr 9:14,337,534...14,351,066
JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 decreases expression EXP Oxycodone results in decreased expression of LCP1 mRNA CTD PMID:23439660 NCBI chr15:50,443,300...50,544,682
Ensembl chr15:50,488,149...50,544,680
JBrowse link
G Lgals3 galectin 3 decreases expression EXP Oxycodone results in decreased expression of LGALS3 mRNA CTD PMID:23439660 NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
JBrowse link
G Lhpp phospholysine phosphohistidine inorganic pyrophosphate phosphatase increases expression EXP Oxycodone results in increased expression of LHPP mRNA CTD PMID:23439660 NCBI chr 1:187,403,390...187,494,577
Ensembl chr 1:187,403,433...187,494,578
JBrowse link
G Lin7a lin-7 homolog A, crumbs cell polarity complex component decreases expression EXP Oxycodone results in decreased expression of LIN7A mRNA CTD PMID:23439660 NCBI chr 7:42,586,704...42,742,609
Ensembl chr 7:42,586,719...42,730,550
JBrowse link
G Ly86 lymphocyte antigen 86 decreases expression EXP Oxycodone results in decreased expression of LY86 mRNA CTD PMID:23439660 NCBI chr17:27,415,807...27,499,695
Ensembl chr17:27,415,830...27,487,260
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation EXP Oxycodone results in increased phosphorylation of MAPK1 protein CTD PMID:26377394 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation EXP Oxycodone results in increased phosphorylation of MAPK3 protein CTD PMID:26377394 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Masp1 MBL associated serine protease 1 decreases expression EXP Oxycodone results in decreased expression of MASP1 mRNA CTD PMID:23439660 NCBI chr11:77,334,794...77,405,271
Ensembl chr11:77,334,859...77,402,974
JBrowse link
G Mtmr7 myotubularin related protein 7 increases expression EXP Oxycodone results in increased expression of MTMR7 mRNA CTD PMID:23439660 NCBI chr16:51,641,225...51,732,212
Ensembl chr16:51,641,190...51,732,182
JBrowse link
G Myo1b myosin Ib increases expression EXP Oxycodone results in increased expression of MYO1B mRNA CTD PMID:23439660 NCBI chr 9:49,690,043...49,852,373
Ensembl chr 9:49,690,086...49,850,798
JBrowse link
G Notch2 notch receptor 2 decreases expression EXP Oxycodone results in decreased expression of NOTCH2 mRNA CTD PMID:23439660 NCBI chr 2:185,610,594...185,744,088
Ensembl chr 2:185,610,589...185,744,088
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression EXP Oxycodone results in increased expression of NR1I2 mRNA CTD PMID:23439660 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression EXP Oxycodone results in increased expression of NR1I3 mRNA CTD PMID:23439660 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Nrep neuronal regeneration related protein decreases expression EXP Oxycodone results in decreased expression of NREP mRNA CTD PMID:23439660 NCBI chr18:25,017,069...25,046,564
Ensembl chr18:25,017,083...25,046,591
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding EXP Oxycodone binds to OPRD1 protein CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding EXP Oxycodone binds to OPRK1 protein CTD PMID:7562497 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprm1 opioid receptor, mu 1 affects binding EXP Oxycodone binds to OPRM1 protein CTD PMID:7562497 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Orm1 orosomucoid 1 decreases expression EXP Oxycodone results in decreased expression of ORM1 mRNA CTD PMID:23439660 NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154
JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 decreases expression EXP Oxycodone results in decreased expression of OSGIN1 mRNA CTD PMID:23439660 NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516
JBrowse link
G Pde4b phosphodiesterase 4B decreases expression EXP Oxycodone results in decreased expression of PDE4B mRNA CTD PMID:23439660 NCBI chr 5:116,799,827...117,367,707
Ensembl chr 5:116,799,971...117,367,696
JBrowse link
G Pdgfra platelet derived growth factor receptor alpha increases expression EXP Oxycodone results in increased expression of PDGFRA protein CTD PMID:26377394 NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335
JBrowse link
G Pfkfb1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 increases expression EXP Oxycodone results in increased expression of PFKFB1 mRNA CTD PMID:23439660 NCBI chr  X:19,508,522...19,562,165
Ensembl chr  X:19,508,546...19,562,182
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 decreases expression EXP Oxycodone results in decreased expression of PIK3C3 mRNA CTD PMID:23439660 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048
JBrowse link
G Pla2g4a phospholipase A2 group IVA decreases expression EXP Oxycodone results in decreased expression of PLA2G4A mRNA CTD PMID:23439660 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
JBrowse link
G Pld1 phospholipase D1 decreases expression EXP Oxycodone results in decreased expression of PLD1 mRNA CTD PMID:23439660 NCBI chr 2:110,849,205...111,047,692
Ensembl chr 2:110,893,608...111,047,692
JBrowse link
G Plscr1 phospholipid scramblase 1 decreases expression EXP Oxycodone results in decreased expression of PLSCR1 mRNA CTD PMID:23439660 NCBI chr 8:92,784,279...92,804,698
Ensembl chr 8:92,784,356...92,804,692
JBrowse link
G Pnpla7 patatin-like phospholipase domain containing 7 increases expression EXP Oxycodone results in increased expression of PNPLA7 mRNA CTD PMID:23439660 NCBI chr 3:7,782,572...7,861,504
Ensembl chr 3:7,782,572...7,861,497
JBrowse link
G Por cytochrome p450 oxidoreductase increases expression EXP Oxycodone results in increased expression of POR mRNA CTD PMID:23439660 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 decreases expression EXP Oxycodone results in decreased expression of PRKAB1 mRNA CTD PMID:23439660 NCBI chr12:40,588,140...40,598,673
Ensembl chr12:40,588,211...40,598,661
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha increases phosphorylation EXP Oxycodone results in increased phosphorylation of PRKACA protein CTD PMID:26377394 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430
JBrowse link
G Prlr prolactin receptor increases expression EXP Oxycodone results in increased expression of PRLR mRNA CTD PMID:23439660 NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718
JBrowse link
G Ptdss2 phosphatidylserine synthase 2 increases expression EXP Oxycodone results in increased expression of PTDSS2 mRNA CTD PMID:23439660 NCBI chr 1:196,241,439...196,267,632
Ensembl chr 1:196,241,494...196,267,685
JBrowse link
G Ptp4a1 protein tyrosine phosphatase 4A1 increases expression EXP Oxycodone results in increased expression of PTP4A1 mRNA CTD PMID:23439660 NCBI chr 9:33,214,201...33,245,046
Ensembl chr 9:33,214,208...33,221,964
JBrowse link
G Pxmp4 peroxisomal membrane protein 4 increases expression EXP Oxycodone results in increased expression of PXMP4 mRNA CTD PMID:23439660 NCBI chr 3:143,093,371...143,110,620
Ensembl chr 3:143,093,018...143,110,651
JBrowse link
G Pycard PYD and CARD domain containing decreases expression EXP Oxycodone results in decreased expression of PYCARD mRNA CTD PMID:23439660 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
JBrowse link
G Rab30 RAB30, member RAS oncogene family increases expression EXP Oxycodone results in increased expression of RAB30 mRNA CTD PMID:23439660 NCBI chr 1:146,803,652...146,898,369
Ensembl chr 1:146,803,714...146,892,181
JBrowse link
G Rab38 RAB38, member RAS oncogene family decreases expression EXP Oxycodone results in decreased expression of RAB38 mRNA CTD PMID:23439660 NCBI chr 1:142,182,566...142,262,923
Ensembl chr 1:142,182,556...142,262,924
JBrowse link
G Rac2 Rac family small GTPase 2 decreases expression EXP Oxycodone results in decreased expression of RAC2 mRNA CTD PMID:23439660 NCBI chr 7:110,101,344...110,128,718
Ensembl chr 7:110,116,260...110,128,720
JBrowse link
G Rcan1 regulator of calcineurin 1 decreases expression EXP Oxycodone results in decreased expression of RCAN1 mRNA CTD PMID:23439660 NCBI chr11:31,622,208...31,702,150
Ensembl chr11:31,622,210...31,702,045
JBrowse link
G Serpina7 serpin family A member 7 decreases expression EXP Oxycodone results in decreased expression of SERPINA7 mRNA CTD PMID:23439660 NCBI chr  X:102,663,242...102,722,319
Ensembl chr  X:102,663,405...102,669,040
JBrowse link
G Skap2 src kinase associated phosphoprotein 2 decreases expression EXP Oxycodone results in decreased expression of SKAP2 mRNA CTD PMID:23439660 NCBI chr 4:80,948,832...81,100,900
Ensembl chr 4:80,950,580...81,100,891
JBrowse link
G Slc10a2 solute carrier family 10 member 2 decreases expression EXP Oxycodone results in decreased expression of SLC10A2 mRNA CTD PMID:23439660 NCBI chr16:84,386,528...84,409,475
Ensembl chr16:84,374,862...84,409,475
JBrowse link
G Slc15a3 solute carrier family 15 member 3 decreases expression EXP Oxycodone results in decreased expression of SLC15A3 mRNA CTD PMID:23439660 NCBI chr 1:207,492,365...207,507,158
Ensembl chr 1:207,492,365...207,507,157
JBrowse link
G Slc16a1 solute carrier family 16 member 1 decreases expression EXP Oxycodone results in decreased expression of SLC16A1 mRNA CTD PMID:23439660 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
JBrowse link
G Slc16a10 solute carrier family 16 member 10 increases expression EXP Oxycodone results in increased expression of SLC16A10 mRNA CTD PMID:23439660 NCBI chr20:43,454,819...43,567,839
Ensembl chr20:43,459,709...43,567,839
JBrowse link
G Slc17a5 solute carrier family 17 member 5 increases expression EXP Oxycodone results in increased expression of SLC17A5 mRNA CTD PMID:23439660 NCBI chr 8:79,394,416...79,429,387 JBrowse link
G Slc1a2 solute carrier family 1 member 2 increases expression EXP Oxycodone results in increased expression of SLC1A2 mRNA CTD PMID:23439660 NCBI chr 3:89,005,129...89,126,498
Ensembl chr 3:89,005,129...89,126,498
JBrowse link
G Slc22a5 solute carrier family 22 member 5 increases expression EXP Oxycodone results in increased expression of SLC22A5 mRNA CTD PMID:23439660 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases expression EXP Oxycodone results in decreased expression of SLC22A8 mRNA CTD PMID:23439660 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Slc25a15 solute carrier family 25 member 15 increases expression EXP Oxycodone results in increased expression of SLC25A15 mRNA CTD PMID:23439660 NCBI chr16:69,631,581...69,654,869
Ensembl chr16:69,634,414...69,653,010
JBrowse link
G Slc25a29 solute carrier family 25 member 29 increases expression EXP Oxycodone results in increased expression of SLC25A29 mRNA CTD PMID:23439660 NCBI chr 6:127,742,027...127,752,915
Ensembl chr 6:127,742,033...127,752,940
JBrowse link
G Slc25a30 solute carrier family 25, member 30 decreases expression EXP Oxycodone results in decreased expression of SLC25A30 mRNA CTD PMID:23439660 NCBI chr15:51,076,998...51,099,613
Ensembl chr15:51,077,002...51,099,613
JBrowse link
G Slc27a5 solute carrier family 27 member 5 increases expression EXP Oxycodone results in increased expression of SLC27A5 mRNA CTD PMID:23439660 NCBI chr 1:73,616,556...73,627,149
Ensembl chr 1:73,616,564...73,627,172
JBrowse link
G Slc2a2 solute carrier family 2 member 2 increases expression EXP Oxycodone results in increased expression of SLC2A2 mRNA CTD PMID:23439660 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
JBrowse link
G Slc34a2 solute carrier family 34 member 2 decreases expression EXP Oxycodone results in decreased expression of SLC34A2 mRNA CTD PMID:23439660 NCBI chr14:57,910,931...57,930,236
Ensembl chr14:57,910,480...57,930,436
JBrowse link
G Slc35b2 solute carrier family 35 member B2 decreases expression EXP Oxycodone results in decreased expression of SLC35B2 mRNA CTD PMID:23439660 NCBI chr 9:15,438,594...15,442,227
Ensembl chr 9:15,438,594...15,442,234
JBrowse link
G Slc37a4 solute carrier family 37 member 4 increases expression EXP Oxycodone results in increased expression of SLC37A4 mRNA CTD PMID:23439660 NCBI chr 8:44,723,216...44,729,301
Ensembl chr 8:44,723,339...44,729,301
JBrowse link
G Slc38a4 solute carrier family 38, member 4 increases expression EXP Oxycodone results in increased expression of SLC38A4 mRNA CTD PMID:23439660 NCBI chr 7:128,142,866...128,203,000
Ensembl chr 7:128,144,807...128,202,995
JBrowse link
G Slc39a4 solute carrier family 39 member 4 increases expression EXP Oxycodone results in increased expression of SLC39A4 mRNA CTD PMID:23439660 NCBI chr 7:108,333,380...108,337,553
Ensembl chr 7:108,333,381...108,337,553
JBrowse link
G Slc41a2 solute carrier family 41 member 2 decreases expression EXP Oxycodone results in decreased expression of SLC41A2 mRNA CTD PMID:23439660 NCBI chr 7:20,383,714...20,491,178
Ensembl chr 7:20,383,757...20,491,166
JBrowse link
G Slc49a4 solute carrier family 49 member 4 increases expression EXP Oxycodone results in increased expression of SLC49A4 mRNA CTD PMID:23439660 NCBI chr11:64,995,629...65,068,929
Ensembl chr11:64,995,679...65,068,926
JBrowse link
G Slc6a9 solute carrier family 6 member 9 decreases expression EXP Oxycodone results in decreased expression of SLC6A9 mRNA CTD PMID:23439660 NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728
JBrowse link
G Slc7a7 solute carrier family 7 member 7 decreases expression EXP Oxycodone results in decreased expression of SLC7A7 mRNA CTD PMID:23439660 NCBI chr15:27,822,088...27,873,121
Ensembl chr15:27,822,091...27,865,648
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 increases expression EXP Oxycodone results in increased expression of SLCO1B2 mRNA CTD PMID:23439660 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor decreases expression EXP Oxycodone results in decreased expression of SLPI mRNA CTD PMID:23439660 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
G Smarcd2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 increases expression EXP Oxycodone results in increased expression of SMARCD2 mRNA CTD PMID:23439660 NCBI chr10:91,193,752...91,202,817
Ensembl chr10:91,193,752...91,204,341
JBrowse link
G Stac3 SH3 and cysteine rich domain 3 decreases expression EXP Oxycodone results in decreased expression of STAC3 mRNA CTD PMID:23439660 NCBI chr 7:63,343,078...63,350,590
Ensembl chr 7:63,343,186...63,350,589
JBrowse link
G Sulf2 sulfatase 2 increases expression EXP Oxycodone results in increased expression of SULF2 mRNA CTD PMID:23439660 NCBI chr 3:154,822,079...154,904,566
Ensembl chr 3:154,822,085...154,904,415
JBrowse link
G Sult1d1 sulfotransferase family 1D, member 1 decreases expression EXP Oxycodone results in decreased expression of SULT1A2 mRNA CTD PMID:23439660 NCBI chr14:20,441,135...20,476,341
Ensembl chr14:20,441,924...20,476,341
JBrowse link
G Sycp3 synaptonemal complex protein 3 increases expression EXP Oxycodone results in increased expression of SYCP3 mRNA CTD PMID:23439660 NCBI chr 7:22,874,055...22,888,512
Ensembl chr 7:22,874,055...22,888,511
JBrowse link
G Tars1 threonyl-tRNA synthetase 1 decreases expression EXP Oxycodone results in decreased expression of TARS1 mRNA CTD PMID:23439660 NCBI chr 2:60,368,251...60,387,733
Ensembl chr 2:60,367,796...60,387,717
JBrowse link
G Thumpd1 THUMP domain containing 1 decreases expression EXP Oxycodone results in decreased expression of THUMPD1 mRNA CTD PMID:23439660 NCBI chr 1:174,078,875...174,084,915 JBrowse link
G Timm8a1 translocase of inner mitochondrial membrane 8A1 increases expression EXP Oxycodone results in increased expression of TIMM8A mRNA CTD PMID:23439660 NCBI chr  X:97,717,932...97,721,918
Ensembl chr  X:97,717,920...97,721,960
JBrowse link
G Tle1 TLE family member 1, transcriptional corepressor increases expression EXP Oxycodone results in increased expression of TLE1 mRNA CTD PMID:23439660 NCBI chr 5:85,851,827...85,934,806
Ensembl chr 5:85,851,827...85,934,774
JBrowse link
G Tmem19 transmembrane protein 19 decreases expression EXP Oxycodone results in decreased expression of TMEM19 mRNA CTD PMID:23439660 NCBI chr 7:50,958,887...51,007,974
Ensembl chr 7:50,958,888...50,986,809
Ensembl chr 7:50,958,888...50,986,809
JBrowse link
G Tsc22d3 TSC22 domain family, member 3 increases expression EXP Oxycodone results in increased expression of TSC22D3 mRNA CTD PMID:23439660 NCBI chr  X:104,217,898...104,277,935
Ensembl chr  X:104,217,925...104,276,861
JBrowse link
G Tsku tsukushi, small leucine rich proteoglycan increases expression EXP Oxycodone results in increased expression of TSKU mRNA CTD PMID:23439660 NCBI chr 1:152,660,259...152,671,682
Ensembl chr 1:152,656,693...152,672,588
JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression EXP Oxycodone results in decreased expression of TUBB5 mRNA CTD PMID:23439660 NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression EXP Oxycodone results in increased expression of UGT1A1 mRNA CTD PMID:23439660 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Usp12 ubiquitin specific peptidase 12 decreases expression EXP Oxycodone results in decreased expression of USP12 mRNA CTD PMID:23439660 NCBI chr12:8,309,845...8,363,686
Ensembl chr12:8,309,750...8,363,656
JBrowse link
G Ust5r integral membrane transport protein UST5r decreases expression EXP Oxycodone results in decreased expression of UST5R mRNA CTD PMID:23439660 NCBI chr 1:205,210,558...205,286,868
Ensembl chr 1:205,211,034...205,286,718
JBrowse link
G Vasp vasodilator-stimulated phosphoprotein decreases expression EXP Oxycodone results in decreased expression of VASP mRNA CTD PMID:23439660 NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061
JBrowse link
G Vim vimentin decreases expression EXP Oxycodone results in decreased expression of VIM mRNA CTD PMID:23439660 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Zfp354a zinc finger protein 354A increases expression EXP Oxycodone results in increased expression of ZNF354A mRNA CTD PMID:23439660 NCBI chr10:35,396,242...35,408,065
Ensembl chr10:35,396,231...35,408,068
JBrowse link
tramadol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A increases expression EXP Tramadol results in increased expression of ADRA1A protein CTD PMID:15464068 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP Tramadol results in increased expression of BAX protein CTD PMID:25550769 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bche butyrylcholinesterase decreases activity EXP Tramadol results in decreased activity of BCHE protein CTD PMID:28689766 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Casp3 caspase 3 affects activity
decreases activity
ISO
EXP
Tramadol affects the activity of CASP3 protein
Tramadol results in decreased activity of CASP3 protein
CTD PMID:27317026 PMID:28499616 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase decreases expression
multiple interactions
EXP Tramadol results in decreased expression of CAT mRNA
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of CAT mRNA]
CTD PMID:25550769 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ckb creatine kinase B decreases expression
multiple interactions
ISO
EXP
Tramadol results in decreased expression of CKB mRNA
Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein]
CTD PMID:27317026 PMID:33645892 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein] CTD PMID:33645892 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity ISO Tramadol results in decreased activity of CYP17A1 protein CTD PMID:29100959 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases response to substance
affects metabolic processing
decreases response to substance
affects response to substance
multiple interactions
decreases methylation
increases metabolic processing
affects methylation
ISO CYP2D6 gene mutant form results in increased susceptibility to Tramadol
CYP2D6 gene mutant form affects the metabolism of Tramadol; CYP2D6 gene polymorphism affects the metabolism of Tramadol
CYP2D6 gene polymorphism results in decreased susceptibility to Tramadol
CYP2D6 affects the susceptibility to Tramadol; CYP2D6 gene polymorphism affects the susceptibility to Tramadol; CYP2D6 protein affects the susceptibility to Tramadol
[CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol] which results in increased chemical synthesis of O-demethyltramadol; CYP2D6 gene polymorphism affects the metabolism of and affects the susceptibility to Tramadol; CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol
CYP2D6 protein results in decreased methylation of Tramadol
CYP2D6 gene mutant form results in increased metabolism of Tramadol; CYP2D6 protein results in increased metabolism of Tramadol
CYP2D6 protein affects the methylation of Tramadol
CTD PMID:12191703 PMID:12893130 PMID:14624403 PMID:16497087 PMID:16960721 More... NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Des desmin multiple interactions EXP Tramadol promotes the reaction [Ethanol results in increased expression of DES protein] CTD PMID:33645892 NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699
JBrowse link
G Drd2 dopamine receptor D2 increases expression EXP Tramadol results in increased expression of DRD2 protein CTD PMID:15464068 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Drd3 dopamine receptor D3 increases expression EXP Tramadol results in increased expression of DRD3 protein CTD PMID:15464068 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP Tramadol promotes the reaction [Ethanol results in increased expression of GJA1 protein] CTD PMID:33645892 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity EXP Tramadol results in increased activity of GPT protein CTD PMID:28689766 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions
increases expression
increases activity
EXP Ketanserin inhibits the reaction [Tramadol results in increased activity of HTR2A protein]
Tramadol results in increased expression of HTR2A mRNA
CTD PMID:18417104 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Ifng interferon gamma multiple interactions EXP Tramadol promotes the reaction [Ethanol results in increased expression of IFNG protein] CTD PMID:33645892 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Ldha lactate dehydrogenase A decreases expression ISO Tramadol results in decreased expression of LDHA mRNA CTD PMID:27317026 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 decreases expression ISO Tramadol results in decreased expression of NDUFS1 mRNA CTD PMID:27317026 NCBI chr 9:64,546,430...64,579,751
Ensembl chr 9:64,546,225...64,579,893
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding
multiple interactions
EXP Tramadol binds to OPRD1 protein
[Tramadol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRD1 protein] which results in decreased uptake of Serotonin
CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 multiple interactions
affects binding
EXP [Tramadol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRK1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding
EXP [Tramadol binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRM1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Pdk3 pyruvate dehydrogenase kinase 3 increases expression ISO Tramadol results in increased expression of PDK3 mRNA CTD PMID:27317026 NCBI chr  X:58,477,471...58,553,932
Ensembl chr  X:58,486,554...58,553,557
JBrowse link
G Pdyn prodynorphin decreases expression EXP Tramadol results in decreased expression of PDYN mRNA CTD PMID:17401159 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP Naloxone inhibits the reaction [Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein] CTD PMID:11723065 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Tramadol inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Tramadol inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression
multiple interactions
EXP Tramadol results in decreased expression of SOD1 mRNA
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD1 mRNA]
CTD PMID:25550769 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
decreases expression
EXP Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD2 mRNA]
Tramadol results in decreased expression of SOD2 mRNA
CTD PMID:25550769 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions
increases expression
EXP Ethanol promotes the reaction [Tramadol results in increased expression of SPP1 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of SPP1 protein] CTD PMID:33645892 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Acetaminophen co-treated with Tramadol] inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNF protein] CTD PMID:17377112 PMID:33645892 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnni3 troponin I3, cardiac type increases expression
multiple interactions
EXP Tramadol results in increased expression of TNNI3 protein
Ethanol promotes the reaction [Tramadol results in increased expression of TNNI3 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNNI3 protein]
CTD PMID:33645892 NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
JBrowse link
G Vim vimentin multiple interactions EXP Tramadol promotes the reaction [Ethanol results in increased expression of VIM protein] CTD PMID:33645892 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
U50488 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grpr gastrin releasing peptide receptor increases phosphorylation
multiple interactions
ISO 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer results in increased phosphorylation of GRPR protein
bisindolylmaleimide inhibits the reaction [3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer results in increased phosphorylation of GRPR protein]
CTD PMID:29669290 NCBI chr  X:30,998,425...31,038,442
Ensembl chr  X:30,998,416...31,038,442
JBrowse link
G Oprk1 opioid receptor, kappa 1 multiple interactions
increases activity
affects response to substance
ISO 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to and results in increased activity of OPRK1 protein; [3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to and results in increased activity of OPRK1 protein] which results in increased phosphorylation of STAT3 protein
3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer results in increased activity of OPRK1 protein
OPRK1 protein affects the susceptibility to 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to and results in increased activity of OPRK1 protein; 7-hydroxymitragynine inhibits the reaction [3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to and results in increased activity of OPRK1 protein]; mitragynine inhibits the reaction [3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to and results in increased activity of OPRK1 protein]
CTD PMID:18385270 PMID:27192616 PMID:27231154 PMID:29669290 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Prkcd protein kinase C, delta multiple interactions
affects localization
ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer affects the localization of PRKCD protein] CTD PMID:29669290 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to and results in increased activity of OPRK1 protein] which results in increased phosphorylation of STAT3 protein CTD PMID:18385270 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      application 19481
        pharmaceutical 19329
          drug 19329
            antitussive 258
              (+-)-menthol 0
              (-)-menthol + 0
              (-)-noscapine 12
              (E,E)-germacrone 11
              (R,R)-tramadol + 32
              (R,R)-tramadol hydrochloride + 0
              (S)-glaucine + 1
              (S,S)-tramadol + 32
              (S,S)-tramadol hydrochloride + 0
              U50488 4
              benproperine 0
              benproperine trihydrogen phosphate 0
              benzonatate 0
              butorphanol + 4
              clofedanol 1
              codeine + 9
              dextromethorphan + 43
              dibunate + 0
              dibunic acid 0
              diphenhydramine + 21
              doxofylline 0
              doxylamine 2
              hydrocodone + 3
              levodropropizine 0
              levomethadone + 32
              levopropoxyphene + 0
              morphine hydrochloride trihydrate 0
              oxycodone 164
              oxycodone hydrochloride + 0
              pholcodine 0
              propoxyphene 0
              racemethorphan 0
              sodium dibunate 0
              tramadol 32
              tramadol hydrochloride 0
paths to the root