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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alfuzosin
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Accession:CHEBI:51141 term browser browse the term
Definition:A tetrahydrofuranol that has formula C19H27N5O4.
Synonyms:exact_synonym: N-{3-[(4-amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino]propyl}tetrahydrofuran-2-carboxamide
 related_synonym: Formula=C19H27N5O4;   InChI=1S/C19H27N5O4/c1-24(8-5-7-21-18(25)14-6-4-9-28-14)19-22-13-11-16(27-3)15(26-2)10-12(13)17(20)23-19/h10-11,14H,4-9H2,1-3H3,(H,21,25)(H2,20,22,23);   InChIKey=WNMJYKCGWZFFKR-UHFFFAOYSA-N;   SMILES=COc1cc2nc(nc(N)c2cc1OC)N(C)CCCNC(=O)C1CCCO1;   alfuzosina;   alfuzosine;   alfuzosinum
 xref: CAS:81403-80-7;   DrugBank:DB00346;   Drug_Central:115;   KEGG:D07124;   LINCS:LSM-1291
 xref_mesh: MESH:C047638
 xref: Patent:DE2904445;   Patent:US4315007;   Wikipedia:Alfuzosin


show annotations for term's descendants           Sort by:
alfuzosin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRA1A adrenoceptor alpha 1A affects binding
multiple interactions		 ISO
EXP		 alfuzosin binds to ADRA1A protein
alfuzosin inhibits the reaction [Prazosin binds to ADRA1A protein]		 CTD PMID:7536677 PMID:8183249 PMID:8196478 PMID:21544540 NCBI chr 8:26,748,150...26,867,379
Ensembl chr 8:26,748,150...26,867,278 		JBrowse link
G ADRA1B adrenoceptor alpha 1B affects binding EXP alfuzosin binds to ADRA1B protein CTD PMID:8183249 NCBI chr 5:159,865,086...159,989,205
Ensembl chr 5:159,865,080...159,973,012 		JBrowse link
G ADRA1D adrenoceptor alpha 1D affects binding EXP
ISO		 alfuzosin binds to ADRA1D protein CTD PMID:8183249 PMID:9294627 NCBI chr20:4,220,630...4,249,287
Ensembl chr20:4,220,630...4,249,287 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO alfuzosin inhibits the reaction [Cyclophosphamide results in increased expression of FOS protein] CTD PMID:17240043 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G GNRH1 gonadotropin releasing hormone 1 multiple interactions ISO alfuzosin inhibits the reaction [Phenylephrine results in decreased secretion of GNRH1 protein]; alfuzosin inhibits the reaction [Phenylephrine results in increased secretion of GNRH1 protein] CTD PMID:1975657 NCBI chr 8:25,419,258...25,425,040
Ensembl chr 8:25,419,258...25,424,654 		JBrowse link
G TAC1 tachykinin precursor 1 multiple interactions ISO alfuzosin inhibits the reaction [Phenylephrine results in increased secretion of TAC1 protein] CTD PMID:17240043 NCBI chr 7:97,732,086...97,740,472
Ensembl chr 7:97,732,084...97,740,472 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      application 25172
        pharmaceutical 24558
          drug 24544
            antineoplastic agent 20859
              alfuzosin 6
                alfuzosin hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      carbon group element atom 25434
                        carbon atom 25403
                          organic molecular entity 25392
                            heteroorganic entity 24766
                              organochalcogen compound 24378
                                organooxygen compound 24054
                                  carbon oxoacid 22749
                                    carboxylic acid 22729
                                      carboacyl group 20055
                                        univalent carboacyl group 20055
                                          carbamoyl group 19568
                                            carboxamide 19580
                                              monocarboxylic acid amide 16961
                                                alfuzosin 6
                                                  alfuzosin hydrochloride 0
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