Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:alfuzosin
go back to main search page
Accession:CHEBI:51141 term browser browse the term
Definition:A tetrahydrofuranol that has formula C19H27N5O4.
Synonyms:exact_synonym: N-{3-[(4-amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino]propyl}tetrahydrofuran-2-carboxamide
 related_synonym: Formula=C19H27N5O4;   InChI=1S/C19H27N5O4/c1-24(8-5-7-21-18(25)14-6-4-9-28-14)19-22-13-11-16(27-3)15(26-2)10-12(13)17(20)23-19/h10-11,14H,4-9H2,1-3H3,(H,21,25)(H2,20,22,23);   InChIKey=WNMJYKCGWZFFKR-UHFFFAOYSA-N;   SMILES=COc1cc2nc(nc(N)c2cc1OC)N(C)CCCNC(=O)C1CCCO1;   alfuzosina;   alfuzosine;   alfuzosinum
 xref: CAS:81403-80-7;   DrugBank:DB00346;   Drug_Central:115;   KEGG:D07124;   LINCS:LSM-1291
 xref_mesh: MESH:C047638
 xref: Patent:DE2904445;   Patent:US4315007;   Wikipedia:Alfuzosin



show annotations for term's descendants           Sort by:
alfuzosin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A affects binding
multiple interactions
EXP
ISO
alfuzosin binds to ADRA1A protein
alfuzosin inhibits the reaction [Prazosin binds to ADRA1A protein]
CTD PMID:7536677 PMID:8183249 PMID:8196478 PMID:21544540 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
JBrowse link
G Adra1b adrenoceptor alpha 1B affects binding ISO alfuzosin binds to ADRA1B protein CTD PMID:8183249 NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919
JBrowse link
G Adra1d adrenoceptor alpha 1D affects binding ISO
EXP
alfuzosin binds to ADRA1D protein CTD PMID:8183249 PMID:9294627 NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP alfuzosin inhibits the reaction [Cyclophosphamide results in increased expression of FOS protein] CTD PMID:17240043 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 multiple interactions EXP alfuzosin inhibits the reaction [Phenylephrine results in decreased secretion of GNRH1 protein]; alfuzosin inhibits the reaction [Phenylephrine results in increased secretion of GNRH1 protein] CTD PMID:1975657 NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP alfuzosin inhibits the reaction [Phenylephrine results in increased secretion of TAC1 protein] CTD PMID:17240043 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      application 19729
        pharmaceutical 19565
          drug 19565
            antineoplastic agent 17770
              alfuzosin 6
                alfuzosin hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic group 18995
                              organic divalent group 18969
                                organodiyl group 18969
                                  carbonyl group 18922
                                    carbonyl compound 18922
                                      carboxylic acid 18646
                                        carboacyl group 17727
                                          univalent carboacyl group 17727
                                            carbamoyl group 17575
                                              carboxamide 17575
                                                monocarboxylic acid amide 15699
                                                  alfuzosin 6
                                                    alfuzosin hydrochloride 0
paths to the root