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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mianserin
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Accession:CHEBI:51137 term browser browse the term
Definition:A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.
Synonyms:exact_synonym: 2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine
 related_synonym: 1,2,3,4,10,14b-Hexahydro-2-methyldibenzo(c,f)pyrazino(1,2-a)azepine;   Formula=C18H20N2;   InChI=1S/C18H20N2/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19/h2-9,18H,10-13H2,1H3;   InChIKey=UEQUQVLFIPOEMF-UHFFFAOYSA-N;   SMILES=CN1CCN2C(C1)c1ccccc1Cc1ccccc21;   mianserina;   mianserine;   mianserinum
 xref: Beilstein:755346;   CAS:24219-97-4;   DrugBank:DB06148;   Drug_Central:1796;   LINCS:LSM-1374
 xref_mesh: MESH:D008803
 xref: PMID:20825390;   Patent:NL6603256;   Patent:US3534041;   Wikipedia:Mianserin


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mianserin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor multiple interactions ISO [Caffeine co-treated with Mianserin] results in decreased expression of ADORA1 mRNA CTD PMID:29882086 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO [Caffeine co-treated with Mianserin] results in decreased expression of COMT mRNA CTD PMID:29882086 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Fgf4 fibroblast growth factor 4 decreases expression ISO Mianserin results in decreased expression of FGF4 mRNA CTD PMID:24154490 NCBI chr 1:218,024,537...218,029,539
Ensembl chr 1:218,025,810...218,027,220
JBrowse link
G Gsc goosecoid homeobox decreases expression ISO Mianserin results in decreased expression of GSC mRNA CTD PMID:24154490 NCBI chr 6:128,147,181...128,149,220
Ensembl chr 6:128,147,181...128,149,220
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions ISO [Mianserin binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Cocaine; Mianserin binds to and results in decreased activity of HTR2A protein CTD PMID:10764922, PMID:10978843 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C increases expression
multiple interactions
ISO Mianserin results in increased expression of HTR2C protein
6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline inhibits the reaction [Mianserin results in increased expression of HTR2C protein]; Mianserin binds to and affects the activity of HTR2C protein
[Mianserin binds to and results in decreased activity of HTR2C protein] which results in decreased susceptibility to Methamphetamine; Mianserin binds to and results in decreased activity of HTR2C protein
CTD PMID:10978843, PMID:15213358, PMID:18083778 NCBI chr  X:118,084,520...118,318,040
Ensembl chr  X:118,084,890...118,318,039
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 affects binding
multiple interactions
ISO Mianserin binds to HTR7 protein
[Mianserin binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]; Mianserin inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]
CTD PMID:14578406, PMID:20827463 NCBI chr 1:254,547,964...254,671,811
Ensembl chr 1:254,547,620...254,671,778
JBrowse link
G Id2 inhibitor of DNA binding 2 decreases expression ISO Mianserin results in decreased expression of ID2 mRNA CTD PMID:24154490 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915
JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions ISO Mianserin affects the activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA]; Mianserin affects the activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr 3:41,019,898...41,181,070
Ensembl chr 3:41,019,898...41,181,070
JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 multiple interactions ISO Mianserin affects the activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA] CTD PMID:22164246 NCBI chr 8:33,435,493...33,463,410
Ensembl chr 8:33,433,905...33,463,467
JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 multiple interactions ISO Mianserin affects the activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr11:35,011,007...35,262,362
Ensembl chr11:35,024,196...35,099,383
JBrowse link
G Prkca protein kinase C, alpha decreases expression ISO Mianserin results in decreased expression of PRKCA mRNA CTD PMID:24154490 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Mianserin inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium] CTD PMID:23770354 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Mianserin inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:21561794 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc6a15 solute carrier family 6 member 15 multiple interactions ISO [Caffeine co-treated with Mianserin] results in decreased expression of SLC6A15 mRNA CTD PMID:29882086 NCBI chr 7:45,328,207...45,381,920
Ensembl chr 7:45,328,105...45,382,229
JBrowse link
G Sox17 SRY-box transcription factor 17 decreases localization ISO Mianserin results in decreased localization of SOX17 protein CTD PMID:24154490 NCBI chr 5:14,890,318...14,895,907
Ensembl chr 5:14,890,408...14,895,907
JBrowse link
G Tac1 tachykinin, precursor 1 decreases expression EXP Mianserin results in decreased expression of TAC1 protein CTD PMID:8955926 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        pharmacological role 18797
          neurotransmitter agent 16425
            adrenergic agent 8935
              adrenergic uptake inhibitor 4685
                mianserin 17
                  mianserin hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      p-block molecular entity 19672
                        carbon group molecular entity 19574
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  organic heteropolycyclic compound 17824
                                    organic heterotricyclic compound 14571
                                      dibenzoazepine 2137
                                        mianserin 17
                                          mianserin hydrochloride 0
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