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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mianserin
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Accession:CHEBI:51137 term browser browse the term
Definition:A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.
Synonyms:exact_synonym: 2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine
 related_synonym: 1,2,3,4,10,14b-Hexahydro-2-methyldibenzo(c,f)pyrazino(1,2-a)azepine;   Formula=C18H20N2;   InChI=1S/C18H20N2/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19/h2-9,18H,10-13H2,1H3;   InChIKey=UEQUQVLFIPOEMF-UHFFFAOYSA-N;   SMILES=CN1CCN2C(C1)c1ccccc1Cc1ccccc21;   mianserina;   mianserine;   mianserinum
 xref: Beilstein:755346;   CAS:24219-97-4;   DrugBank:DB06148;   Drug_Central:1796;   LINCS:LSM-1374
 xref_mesh: MESH:D008803
 xref: PMID:20825390;   Patent:NL6603256;   Patent:US3534041;   Wikipedia:Mianserin



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mianserin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor multiple interactions ISO [Caffeine co-treated with Mianserin] results in decreased expression of ADORA1 mRNA CTD PMID:29882086 NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801
JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO [Caffeine co-treated with Mianserin] results in decreased expression of COMT mRNA CTD PMID:29882086 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Fgf4 fibroblast growth factor 4 decreases expression ISO Mianserin results in decreased expression of FGF4 mRNA CTD PMID:24154490 NCBI chr 1:200,023,937...200,027,793
Ensembl chr 1:200,024,056...200,025,466
JBrowse link
G Gsc goosecoid homeobox decreases expression ISO Mianserin results in decreased expression of GSC mRNA CTD PMID:24154490 NCBI chr 6:123,388,072...123,390,111
Ensembl chr 6:123,388,072...123,390,111
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions ISO [Mianserin binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Cocaine; Mianserin binds to and results in decreased activity of HTR2A protein CTD PMID:10764922 PMID:10978843 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C increases expression
multiple interactions
ISO Mianserin results in increased expression of HTR2C protein
6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline inhibits the reaction [Mianserin results in increased expression of HTR2C protein]; Mianserin binds to and affects the activity of HTR2C protein
[Mianserin binds to and results in decreased activity of HTR2C protein] which results in decreased susceptibility to Methamphetamine; Mianserin binds to and results in decreased activity of HTR2C protein
CTD PMID:10978843 PMID:15213358 PMID:18083778 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 affects binding
multiple interactions
ISO Mianserin binds to HTR7 protein
[Mianserin binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]; Mianserin inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]
CTD PMID:14578406 PMID:20827463 NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626
JBrowse link
G Id2 inhibitor of DNA binding 2 decreases expression ISO Mianserin results in decreased expression of ID2 mRNA CTD PMID:24154490 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions ISO Mianserin affects the activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA]; Mianserin affects the activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr 3:39,944,896...40,106,646
Ensembl chr 3:39,945,351...40,109,124
JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 multiple interactions ISO Mianserin affects the activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA] CTD PMID:22164246 NCBI chr 8:30,724,923...30,753,083
Ensembl chr 8:30,724,925...30,753,518
JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 multiple interactions ISO Mianserin affects the activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr11:34,061,705...34,309,128
Ensembl chr11:34,061,708...34,308,758
JBrowse link
G Prkca protein kinase C, alpha decreases expression ISO Mianserin results in decreased expression of PRKCA mRNA CTD PMID:24154490 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Mianserin inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium] CTD PMID:23770354 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Mianserin inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:21561794 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc6a15 solute carrier family 6 member 15 multiple interactions ISO [Caffeine co-treated with Mianserin] results in decreased expression of SLC6A15 mRNA CTD PMID:29882086 NCBI chr 7:38,553,055...38,607,239
Ensembl chr 7:38,553,196...38,607,239
JBrowse link
G Sox17 SRY-box transcription factor 17 decreases localization ISO Mianserin results in decreased localization of SOX17 protein CTD PMID:24154490 NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228
JBrowse link
G Tac1 tachykinin, precursor 1 decreases expression EXP Mianserin results in decreased expression of TAC1 protein CTD PMID:8955926 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link

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  CHEBI ontology 19808
    role 19757
      biological role 19757
        pharmacological role 18838
          neurotransmitter agent 16452
            adrenergic agent 8968
              adrenergic uptake inhibitor 4719
                mianserin 17
                  mianserin hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19807
      composite particle 19807
        hadron 19807
          baryon 19807
            nucleon 19807
              atomic nucleus 19807
                atom 19807
                  main group element atom 19704
                    p-block element atom 19704
                      p-block molecular entity 19704
                        carbon group molecular entity 19626
                          organic molecular entity 19616
                            organic molecule 19556
                              organic cyclic compound 19347
                                organic heterocyclic compound 18580
                                  organic heteropolycyclic compound 18057
                                    organic heterotricyclic compound 14649
                                      dibenzoazepine 2142
                                        mianserin 17
                                          mianserin hydrochloride 0
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