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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fluorescent dye
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Accession:CHEBI:51121 term browser browse the term
Synonyms:related_synonym: fluorescent dyes



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2',7'-bis-(2-carboxyethyl)carboxyfluorescein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 multiple interactions ISO Mefloquine inhibits the reaction [ABCC4 protein affects the export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; verlukast inhibits the reaction [ABCC4 protein affects the export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein] CTD PMID:16004972 NCBI chr14:118,720,104...118,945,475
Ensembl chr14:118,720,104...118,943,631
JBrowse link
G Abcc5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 increases export
multiple interactions
ISO ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein
daidzein inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; hesperetin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; naringenin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; Quercetin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; resveratrol inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; Silymarin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; verlukast inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]
CTD PMID:16156793 NCBI chr16:20,150,053...20,245,178
Ensembl chr16:20,150,053...20,245,144
JBrowse link
2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 multiple interactions
decreases activity
ISO bisbenzimide ethoxide trihydrochloride inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
bisbenzimide ethoxide trihydrochloride results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,960
JBrowse link
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A multiple interactions
increases transport
ISO
EXP
[zosuquidar trihydrochloride results in decreased activity of ABCB1 protein] which results in decreased export of bisbenzimide ethoxide trihydrochloride; abamectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; emamectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Ivermectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride
abamectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; emamectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Ivermectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
CTD PMID:25865432 PMID:34896433 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
JBrowse link
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 multiple interactions
increases transport
ISO
EXP
abamectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; emamectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Ivermectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride] CTD PMID:25865432 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) decreases abundance
decreases export
decreases activity
multiple interactions
increases export
increases transport
ISO ABCG2 protein results in decreased abundance of bisbenzimide ethoxide trihydrochloride
ABCG2 protein polymorphism results in decreased export of bisbenzimide ethoxide trihydrochloride
bisbenzimide ethoxide trihydrochloride results in decreased activity of ABCG2 protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] which results in decreased export of bisbenzimide ethoxide trihydrochloride; [MLN 8237 affects the activity of ABCG2 protein] which affects the export of bisbenzimide ethoxide trihydrochloride; [MYC protein results in increased expression of ABCG2 protein] which results in increased export of bisbenzimide ethoxide trihydrochloride; Cimetidine inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Cyclosporine inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; danofloxacin inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Genistein inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Genistein promotes the reaction [ABCG2 protein polymorphism results in decreased export of bisbenzimide ethoxide trihydrochloride]; Methotrexate inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Nitrofurantoin inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Porphyrins inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Reserpine inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Tobacco Smoke Pollution inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; tryptoquivaline inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; verlukast inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
CTD PMID:12869632 PMID:19239227 PMID:26850786 PMID:26907376 PMID:27450509 More... NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661
JBrowse link
G Keap1 kelch-like ECH-associated protein 1 decreases export ISO KEAP1 protein results in decreased export of bisbenzimide ethoxide trihydrochloride CTD PMID:25841332 NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657
JBrowse link
G Myc myelocytomatosis oncogene multiple interactions ISO [MYC protein results in increased expression of ABCG2 protein] which results in increased export of bisbenzimide ethoxide trihydrochloride CTD PMID:19239227 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
JBrowse link
3,4-dihydrocoumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddit3 DNA-damage inducible transcript 3 affects expression EXP 3,4-dihydrocoumarin affects the expression of DDIT3 mRNA CTD PMID:22016648 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157
JBrowse link
G Dnaja2 DnaJ heat shock protein family (Hsp40) member A2 decreases expression EXP 3,4-dihydrocoumarin results in decreased expression of DNAJA2 mRNA CTD PMID:22016648 NCBI chr 8:86,264,262...86,281,990
Ensembl chr 8:86,264,262...86,281,973
JBrowse link
G Egf epidermal growth factor increases expression EXP 3,4-dihydrocoumarin results in increased expression of EGF mRNA CTD PMID:22016648 NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965
JBrowse link
G Ephx1 epoxide hydrolase 1, microsomal decreases expression EXP 3,4-dihydrocoumarin results in decreased expression of EPHX1 mRNA CTD PMID:22016648 NCBI chr 1:180,817,121...180,845,134
Ensembl chr 1:180,803,775...180,848,469
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 increases expression EXP 3,4-dihydrocoumarin results in increased expression of HSD17B4 mRNA CTD PMID:22016648 NCBI chr18:50,261,268...50,329,337
Ensembl chr18:50,261,268...50,329,336
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 decreases expression EXP 3,4-dihydrocoumarin results in decreased expression of HSP90AB1 mRNA CTD PMID:22016648 NCBI chr17:45,878,704...45,884,187
Ensembl chr17:45,878,701...45,884,197
JBrowse link
G Hspa1a heat shock protein 1A increases expression EXP 3,4-dihydrocoumarin results in increased expression of HSPA1A mRNA CTD PMID:22016648 NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132
JBrowse link
G Kap kidney androgen regulated protein decreases expression EXP 3,4-dihydrocoumarin results in decreased expression of KAP mRNA CTD PMID:22016648 NCBI chr 6:133,826,818...133,830,630
Ensembl chr 6:133,826,814...133,830,725
JBrowse link
G Oat ornithine aminotransferase decreases expression EXP 3,4-dihydrocoumarin results in decreased expression of OAT mRNA CTD PMID:22016648 NCBI chr 7:132,159,204...132,178,127
Ensembl chr 7:132,159,207...132,178,127
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic decreases expression EXP 3,4-dihydrocoumarin results in decreased expression of PCK1 mRNA CTD PMID:22016648 NCBI chr 2:172,994,866...173,001,067
Ensembl chr 2:172,994,841...173,001,066
JBrowse link
G Pon1 paraoxonase 1 affects metabolic processing ISO PON1 SNP affects the metabolism of 3,4-dihydrocoumarin CTD PMID:25027835 NCBI chr 6:5,168,090...5,193,987
Ensembl chr 6:5,168,090...5,193,946
JBrowse link
G Prdx1 peroxiredoxin 1 increases expression EXP 3,4-dihydrocoumarin results in increased expression of PRDX1 mRNA CTD PMID:22016648 NCBI chr 4:116,542,796...116,557,197
Ensembl chr 4:116,542,741...116,558,019
JBrowse link
G Prdx3 peroxiredoxin 3 decreases expression EXP 3,4-dihydrocoumarin results in decreased expression of PRDX3 mRNA CTD PMID:22016648 NCBI chr19:60,852,504...60,862,976
Ensembl chr19:60,852,489...60,862,994
JBrowse link
G Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) decreases expression EXP 3,4-dihydrocoumarin results in decreased expression of PSMB8 mRNA CTD PMID:22016648 NCBI chr17:34,417,169...34,420,428
Ensembl chr17:34,416,695...34,420,428
JBrowse link
G Ptpmt1 protein tyrosine phosphatase, mitochondrial 1 decreases expression EXP 3,4-dihydrocoumarin results in decreased expression of PTPMT1 mRNA CTD PMID:22016648 NCBI chr 2:90,741,057...90,748,395
Ensembl chr 2:90,739,060...90,748,389
JBrowse link
G Rbp4 retinol binding protein 4, plasma decreases expression EXP 3,4-dihydrocoumarin results in decreased expression of RBP4 mRNA CTD PMID:22016648 NCBI chr19:38,105,068...38,113,769
Ensembl chr19:38,105,077...38,113,729
JBrowse link
G Sod1 superoxide dismutase 1, soluble decreases expression EXP 3,4-dihydrocoumarin results in decreased expression of SOD1 mRNA CTD PMID:22016648 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
JBrowse link
G Timp2 tissue inhibitor of metalloproteinase 2 decreases expression EXP 3,4-dihydrocoumarin results in decreased expression of TIMP2 mRNA CTD PMID:22016648 NCBI chr11:118,191,887...118,246,237
Ensembl chr11:118,191,895...118,246,566
JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression EXP 3,4-dihydrocoumarin results in decreased expression of TUBB5 mRNA CTD PMID:22016648 NCBI chr17:36,144,812...36,149,193
Ensembl chr17:36,144,813...36,149,198
JBrowse link
5(6)-carboxy-2',7'-dichlorofluorescein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 affects transport
multiple interactions
increases export
increases transport
ISO ABCC2 protein affects the transport of 5(6)-carboxy-2',7'-dichlorofluorescein
4-hydroxy-2-nonenal inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein; Ascorbic Acid inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]]; Ascorbic Acid promotes the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Atorvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Benzbromarone inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Calcium deficiency inhibits the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; cyanoginosin LR inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Cyclosporine inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Fluvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Lovastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; microcystin RR inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; microcystin-LF inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; pitavastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Pravastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Probenecid inhibits the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein analog]; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Simvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Tobacco Smoke Pollution inhibits the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein analog]
ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein; ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein analog
[ABCC2 gene mutant form results in increased expression of ABCC3 protein] which results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein; ABCC2 gene mutant form inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein; Atorvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Fluvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Fluvastatin promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; Lovastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; pitavastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Pravastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Pravastatin promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Rosuvastatin Calcium promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; Simvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]
CTD PMID:19326901 PMID:21240898 PMID:21341280 PMID:23562342 PMID:24907646 More... NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
JBrowse link
G Abcc3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 multiple interactions
increases transport
ISO [ABCC2 gene mutant form results in increased expression of ABCC3 protein] which results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein
Benzbromarone inhibits the reaction [ABCC3 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]
CTD PMID:24907646 PMID:31348918 NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823
JBrowse link
G Abcc5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 multiple interactions
increases transport
ISO Benzbromarone inhibits the reaction [ABCC5 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein] CTD PMID:31348918 NCBI chr16:20,150,053...20,245,178
Ensembl chr16:20,150,053...20,245,144
JBrowse link
5-carboxyfluorescein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 multiple interactions
increases transport
ISO quercetin 3'-sulfate inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein]; quercetin 3-O-glucuronide analog inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein]; quercetin 3-O-glucuronide inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein] CTD PMID:21244849 NCBI chr19:8,568,545...8,589,199
Ensembl chr19:8,568,618...8,589,199
JBrowse link
5-chloromethylfluorescein diacetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 multiple interactions ISO ABCC2 protein affects the transport of [5-chloromethylfluorescein co-treated with Glutathione] CTD PMID:16049127 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
JBrowse link
6-carboxyfluorescein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 increases export ISO ABCC1 protein results in increased export of 6-carboxyfluorescein CTD PMID:17940500 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601
JBrowse link
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 affects export
multiple interactions
ISO ABCC2 protein affects the export of 6-carboxyfluorescein
Probenecid inhibits the reaction [ABCC2 protein affects the export of 6-carboxyfluorescein]
CTD PMID:11477083 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
JBrowse link
G Slc22a6 solute carrier family 22 (organic anion transporter), member 6 increases import
multiple interactions
ISO SLC22A6 protein results in increased import of 6-carboxyfluorescein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein]; glutaric acid promotes the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein]; Probenecid inhibits the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein]
CTD PMID:28629854 NCBI chr19:8,595,360...8,605,663
Ensembl chr19:8,595,403...8,605,663
JBrowse link
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 increases import
multiple interactions
ISO SLC22A8 protein results in increased import of 6-carboxyfluorescein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine promotes the reaction [2-amino-9H-pyrido(2,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]]; 2-amino-9H-pyrido(2,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; 2-amino-9H-pyrido(2,3-b)indole promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]]; 3-amino-1-methyl-5H-pyrido(4,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; Cadmium Chloride promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; glutaric acid promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; lead chloride promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; Probenecid inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; sodium arsenate promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]
CTD PMID:28629854 NCBI chr19:8,568,545...8,589,199
Ensembl chr19:8,568,618...8,589,199
JBrowse link
9-aminoacridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase affects binding
decreases activity
ISO Aminacrine binds to ACHE protein
Aminacrine results in decreased activity of ACHE protein
CTD PMID:31176713 PMID:33844597 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
JBrowse link
G Bax BCL2-associated X protein increases response to substance ISO BAX protein results in increased susceptibility to Aminacrine CTD PMID:16177561 NCBI chr 7:45,111,119...45,116,344
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G H2ax H2A.X variant histone decreases phosphorylation
multiple interactions
ISO Aminacrine results in decreased phosphorylation of H2AX protein
[Aminacrine results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]
CTD PMID:26928355 NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit increases activity ISO Aminacrine results in increased activity of HIF1A protein CTD PMID:19502547 NCBI chr12:73,948,098...73,994,328
Ensembl chr12:73,948,149...73,994,304
JBrowse link
G Mdc1 mediator of DNA damage checkpoint 1 multiple interactions ISO [Aminacrine results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]; Aminacrine inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein] CTD PMID:26928355 NCBI chr17:36,152,390...36,170,562
Ensembl chr17:36,152,407...36,170,562
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Aminacrine inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447
JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO Aminacrine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO Aminacrine results in increased stability of and results in increased activity of TP53 protein CTD PMID:16177561 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
acridine orange term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2-associated X protein increases response to substance ISO BAX protein results in increased susceptibility to Acridine Orange CTD PMID:16177561 NCBI chr 7:45,111,119...45,116,344
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions ISO [Acridine Orange binds to Platinum Compounds] which results in increased expression of GSTP1 mRNA; [Acridine Orange binds to Platinum] which results in increased expression of GSTP1 mRNA CTD PMID:16814760 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO Acridine Orange results in increased stability of and results in increased activity of TP53 protein CTD PMID:16177561 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
acridine orange free base term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2-associated X protein increases response to substance ISO BAX protein results in increased susceptibility to Acridine Orange CTD PMID:16177561 NCBI chr 7:45,111,119...45,116,344
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions ISO [Acridine Orange binds to Platinum Compounds] which results in increased expression of GSTP1 mRNA; [Acridine Orange binds to Platinum] which results in increased expression of GSTP1 mRNA CTD PMID:16814760 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO Acridine Orange results in increased stability of and results in increased activity of TP53 protein CTD PMID:16177561 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
auramine O term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 increases expression
multiple interactions
ISO Benzophenoneidum results in increased expression of ALDH1A1 protein
ALDH1A1 protein promotes the reaction [Benzophenoneidum results in increased lipidation of and results in increased cleavage of MAP1LC3B protein]
CTD PMID:28722353 NCBI chr19:20,469,947...20,620,827
Ensembl chr19:20,470,079...20,620,829
JBrowse link
G Ano6 anoctamin 6 increases expression ISO Benzophenoneidum results in increased expression of ANO6 protein CTD PMID:28722353 NCBI chr15:95,688,724...95,873,353
Ensembl chr15:95,688,724...95,872,632
JBrowse link
G Araf Araf proto-oncogene, serine/threonine kinase increases expression ISO Benzophenoneidum results in increased expression of ARAF protein CTD PMID:28722353 NCBI chr  X:20,663,946...20,726,760
Ensembl chr  X:20,664,053...20,726,758
JBrowse link
G Atp6ap2 ATPase, H+ transporting, lysosomal accessory protein 2 increases expression ISO Benzophenoneidum results in increased expression of ATP6AP2 protein CTD PMID:28722353 NCBI chr  X:12,453,998...12,483,290
Ensembl chr  X:12,454,040...12,483,288
JBrowse link
G Ccdc22 coiled-coil domain containing 22 increases expression ISO Benzophenoneidum results in increased expression of CCDC22 protein CTD PMID:28722353 NCBI chr  X:7,460,048...7,471,659
Ensembl chr  X:7,460,048...7,471,756
JBrowse link
G Ccdc39 coiled-coil domain containing 39 increases expression ISO Benzophenoneidum results in increased expression of CCDC39 protein CTD PMID:28722353 NCBI chr 3:33,864,906...33,898,473
Ensembl chr 3:33,866,511...33,898,459
JBrowse link
G Cd44 CD44 antigen increases expression ISO Benzophenoneidum results in increased expression of CD44 protein CTD PMID:28722353 NCBI chr 2:102,641,486...102,732,014
Ensembl chr 2:102,641,486...102,732,010
JBrowse link
G Chtf18 CTF18, chromosome transmission fidelity factor 18 increases expression ISO Benzophenoneidum results in increased expression of CHTF18 protein CTD PMID:28722353 NCBI chr17:25,938,004...25,946,409
Ensembl chr17:25,937,900...25,946,393
JBrowse link
G Commd1 COMM domain containing 1 increases expression ISO Benzophenoneidum results in increased expression of COMMD1 protein CTD PMID:28722353 NCBI chr11:22,849,728...22,934,539
Ensembl chr11:22,846,136...22,932,382
JBrowse link
G Cops7b COP9 signalosome subunit 7B increases expression ISO Benzophenoneidum results in increased expression of COPS7B protein CTD PMID:28722353 NCBI chr 1:86,510,363...86,534,550
Ensembl chr 1:86,510,626...86,537,097
JBrowse link
G Cul3 cullin 3 increases expression ISO Benzophenoneidum results in increased expression of CUL3 protein CTD PMID:28722353 NCBI chr 1:80,242,640...80,318,407
Ensembl chr 1:80,242,640...80,318,197
JBrowse link
G Dynlt1b dynein light chain Tctex-type 1B increases expression ISO Benzophenoneidum results in increased expression of DYNLT1 protein CTD PMID:28722353 NCBI chr17:6,697,511...6,703,695
Ensembl chr17:6,697,511...6,703,695
JBrowse link
G Eif4g3 eukaryotic translation initiation factor 4 gamma, 3 increases expression ISO Benzophenoneidum results in increased expression of EIF4G3 protein CTD PMID:28722353 NCBI chr 4:137,719,090...137,934,397
Ensembl chr 4:137,720,333...137,935,819
JBrowse link
G Fastkd2 FAST kinase domains 2 increases expression ISO Benzophenoneidum results in increased expression of FASTKD2 protein CTD PMID:28722353 NCBI chr 1:63,769,758...63,792,544
Ensembl chr 1:63,769,773...63,793,814
JBrowse link
G Hook3 hook microtubule tethering protein 3 increases expression ISO Benzophenoneidum results in increased expression of HOOK3 protein CTD PMID:28722353 NCBI chr 8:26,511,449...26,609,646
Ensembl chr 8:26,511,449...26,609,252
JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 increases expression ISO Benzophenoneidum results in increased expression of HSD17B7 protein CTD PMID:28722353 NCBI chr 1:169,777,104...169,796,913
Ensembl chr 1:169,777,104...169,796,810
JBrowse link
G Htt huntingtin increases expression ISO Benzophenoneidum results in increased expression of HTT protein CTD PMID:28722353 NCBI chr 5:34,919,084...35,069,878
Ensembl chr 5:34,919,084...35,069,878
JBrowse link
G Iqgap3 IQ motif containing GTPase activating protein 3 increases expression ISO Benzophenoneidum results in increased expression of IQGAP3 protein CTD PMID:28722353 NCBI chr 3:87,989,309...88,028,355
Ensembl chr 3:87,989,278...88,028,355
JBrowse link
G Kifap3 kinesin-associated protein 3 increases expression ISO Benzophenoneidum results in increased expression of KIFAP3 protein CTD PMID:28722353 NCBI chr 1:163,589,711...163,744,676
Ensembl chr 1:163,607,152...163,744,678
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO ALDH1A1 protein promotes the reaction [Benzophenoneidum results in increased lipidation of and results in increased cleavage of MAP1LC3B protein]; Benzophenoneidum results in increased lipidation of and results in increased cleavage of MAP1LC3B protein CTD PMID:28722353 NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499
JBrowse link
G Map2k4 mitogen-activated protein kinase kinase 4 increases expression ISO Benzophenoneidum results in increased expression of MAP2K4 protein CTD PMID:28722353 NCBI chr11:65,579,070...65,679,185
Ensembl chr11:65,579,069...65,679,123
JBrowse link
G Mbd3 methyl-CpG binding domain protein 3 increases expression ISO Benzophenoneidum results in increased expression of MBD3 protein CTD PMID:28722353 NCBI chr10:80,228,373...80,235,365
Ensembl chr10:80,228,373...80,235,384
JBrowse link
G Noa1 nitric oxide associated 1 increases expression ISO Benzophenoneidum results in increased expression of NOA1 protein CTD PMID:28722353 NCBI chr 5:77,442,016...77,458,276
Ensembl chr 5:77,442,029...77,457,931
JBrowse link
G Nup62 nucleoporin 62 increases expression ISO Benzophenoneidum results in increased expression of NUP62 protein CTD PMID:28722353 NCBI chr 7:44,465,512...44,481,260
Ensembl chr 7:44,465,512...44,480,236
JBrowse link
G Plcg1 phospholipase C, gamma 1 increases expression ISO Benzophenoneidum results in increased expression of PLCG1 protein CTD PMID:28722353 NCBI chr 2:160,573,230...160,617,680
Ensembl chr 2:160,573,220...160,617,680
JBrowse link
G Ppp4r1 protein phosphatase 4, regulatory subunit 1 increases expression ISO Benzophenoneidum results in increased expression of PPP4R1 protein CTD PMID:28722353 NCBI chr17:66,089,253...66,148,921
Ensembl chr17:66,089,568...66,148,921
JBrowse link
G Prim2 DNA primase, p58 subunit increases expression ISO Benzophenoneidum results in increased expression of PRIM2 protein CTD PMID:28722353 NCBI chr 1:33,492,889...33,708,875
Ensembl chr 1:33,492,891...33,708,876
JBrowse link
G Prom1 prominin 1 increases expression ISO Benzophenoneidum results in increased expression of PROM1 protein CTD PMID:28722353 NCBI chr 5:44,150,963...44,260,850
Ensembl chr 5:44,150,962...44,259,374
JBrowse link
G Prorp protein only RNase P catalytic subunit increases expression ISO Benzophenoneidum results in increased expression of PRORP protein CTD PMID:28722353 NCBI chr12:55,349,422...55,429,276
Ensembl chr12:55,346,362...55,429,318
JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 (soluble) increases expression ISO Benzophenoneidum results in increased expression of SHMT1 protein CTD PMID:28722353 NCBI chr11:60,678,933...60,702,091
Ensembl chr11:60,678,930...60,702,544
JBrowse link
G Srsf11 serine and arginine-rich splicing factor 11 increases expression ISO Benzophenoneidum results in increased expression of SRSF11 protein CTD PMID:28722353 NCBI chr 3:157,716,552...157,742,311
Ensembl chr 3:157,716,110...157,742,276
JBrowse link
G Tbc1d15 TBC1 domain family, member 15 increases expression ISO Benzophenoneidum results in increased expression of TBC1D15 protein CTD PMID:28722353 NCBI chr10:115,033,776...115,087,401
Ensembl chr10:115,033,777...115,087,372
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO Benzophenoneidum results in increased expression of TFAM protein CTD PMID:28722353 NCBI chr10:71,061,298...71,074,157
Ensembl chr10:71,061,294...71,074,110
JBrowse link
G Usp24 ubiquitin specific peptidase 24 increases expression ISO Benzophenoneidum results in increased expression of USP24 protein CTD PMID:28722353 NCBI chr 4:106,173,179...106,303,798
Ensembl chr 4:106,173,410...106,298,519
JBrowse link
G Washc5 WASH complex subunit 5 increases expression ISO Benzophenoneidum results in increased expression of WASHC5 protein CTD PMID:28722353 NCBI chr15:59,203,712...59,246,043
Ensembl chr15:59,203,846...59,246,016
JBrowse link
aurintricarboxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lig1 ligase I, DNA, ATP-dependent decreases activity ISO Aurintricarboxylic Acid results in decreased activity of LIG1 protein CTD PMID:15134906 NCBI chr 7:13,011,101...13,045,351
Ensembl chr 7:13,011,239...13,045,350
JBrowse link
G Ogg1 8-oxoguanine DNA-glycosylase 1 decreases activity ISO Aurintricarboxylic Acid results in decreased activity of OGG1 protein CTD PMID:26218629 NCBI chr 6:113,303,871...113,311,838
Ensembl chr 6:113,303,933...113,312,029
JBrowse link
azure A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpt glutamic pyruvic transaminase, soluble increases activity ISO Azure A results in increased activity of GPT protein CTD PMID:33775737 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
JBrowse link
azure B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta (A4) precursor protein multiple interactions ISO [Azure B affects the cleavage of APP protein] which results in decreased secretion of APP protein modified form; Azure B results in decreased expression of and affects the cleavage of APP protein CTD PMID:30500345 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
JBrowse link
G Bace1 beta-site APP cleaving enzyme 1 decreases activity ISO Azure B results in decreased activity of BACE1 protein CTD PMID:30500345 NCBI chr 9:45,749,843...45,774,791
Ensembl chr 9:45,749,878...45,775,697
JBrowse link
brilliant green term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO brilliant green results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:26177467 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp7 caspase 7 multiple interactions ISO brilliant green results in increased cleavage of and results in increased activity of CASP7 protein CTD PMID:26177467 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO brilliant green results in decreased expression of CCND1 protein CTD PMID:26177467 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Ikbke inhibitor of kappaB kinase epsilon decreases expression ISO brilliant green results in decreased expression of IKBKE protein CTD PMID:26177467 NCBI chr 1:131,182,337...131,207,339
Ensembl chr 1:131,182,080...131,207,344
JBrowse link
G Lonp1 lon peptidase 1, mitochondrial increases expression ISO brilliant green results in increased expression of LONP1 mRNA CTD PMID:21215310 NCBI chr17:56,921,297...56,933,903
Ensembl chr17:56,921,297...56,933,887
JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO brilliant green inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
JBrowse link
G Txn1 thioredoxin 1 increases oxidation ISO brilliant green results in increased oxidation of TXN protein CTD PMID:21215310 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411
JBrowse link
G Txn2 thioredoxin 2 multiple interactions
affects response to substance
decreases expression
ISO brilliant green results in increased oxidation of and results in increased degradation of TXN2 protein
TXN2 protein affects the susceptibility to brilliant green
brilliant green results in decreased expression of TXN2 protein
CTD PMID:21215310 NCBI chr15:77,799,251...77,813,194
Ensembl chr15:77,799,247...77,813,206
JBrowse link
C3-thiacarbocyanine cation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity ISO Dithiazanine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
JBrowse link
calcein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A multiple interactions
increases secretion
increases export
ISO
EXP
[carvedilol results in decreased activity of ABCB1 protein] which results in increased uptake of fluorexon; [Verapamil results in decreased activity of ABCB1 protein] which results in increased uptake of fluorexon; Beclomethasone inhibits the reaction [ABCB1 protein results in increased export of fluorexon]; Clotrimazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Cyclosporine inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; desisobutyrylciclesonide inhibits the reaction [ABCB1 protein results in increased export of fluorexon]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Miconazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Mometasone Furoate inhibits the reaction [ABCB1 protein results in increased export of fluorexon]; Reserpine inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Troleandomycin inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of fluorexon]
Amiodarone inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Clotrimazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Cyclosporine inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Ketoconazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Miconazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Reserpine inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Troleandomycin inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]
CTD PMID:10571255 PMID:12235267 PMID:16442095 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
JBrowse link
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 affects export
increases export
increases import
affects transport
multiple interactions
ISO
EXP
ABCC1 protein affects the export of fluorexon
ABCC1 protein results in increased export of fluorexon
ABCC1 protein results in increased import of fluorexon
ABCC1 protein affects the transport of fluorexon
Mefloquine inhibits the reaction [ABCC1 protein affects the export of fluorexon]; nobiletin promotes the reaction [ABCC1 protein results in increased import of fluorexon]; Quercetin inhibits the reaction [ABCC1 protein results in increased export of fluorexon]; robinetin inhibits the reaction [ABCC1 protein affects the export of fluorexon]; Silymarin inhibits the reaction [ABCC1 protein results in increased export of fluorexon]; verlukast inhibits the reaction [ABCC1 protein affects the export of fluorexon]; verlukast inhibits the reaction [ABCC1 protein results in increased export of fluorexon]; Vincristine inhibits the reaction [ABCC1 protein affects the transport of fluorexon]
CTD PMID:10685512 PMID:15670588 PMID:16004972 PMID:16156793 PMID:18955043 More... NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601
JBrowse link
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 affects export
increases abundance
multiple interactions
affects transport
ISO ABCC2 protein affects the export of fluorexon
ABCC2 protein alternative form results in increased abundance of fluorexon
robinetin inhibits the reaction [ABCC2 protein affects the export of fluorexon]
ABCC2 protein affects the transport of fluorexon
CTD PMID:15670588 PMID:15848949 PMID:22027652 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
JBrowse link
G Abcc6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 affects transport ISO ABCC6 affects the transport of fluorexon CTD PMID:14667841 NCBI chr 7:45,625,804...45,679,915
Ensembl chr 7:45,616,979...45,679,726
JBrowse link
calcein am term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 affects export
multiple interactions
EXP ABCB11 protein affects the export of calcein AM
ditekiren inhibits the reaction [ABCB11 protein affects the export of calcein AM]
CTD PMID:10617675 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,960
JBrowse link
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A increases transport
increases export
multiple interactions
increases activity
affects export
increases secretion
ISO ABCB1 protein results in increased transport of calcein AM
ABCB1 protein results in increased export of calcein AM
ABCB1A protein promotes the reaction [Emodin results in increased export of calcein AM]
2-methoxy-N-(3-(4-((3-methyl-4-((6-methyl-3-pyridinyl)oxy)phenyl)amino)-6-quinazolinyl)-2-propenyl)acetamide inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; [Endosulfan co-treated with Verapamil] inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; [phosalone co-treated with Verapamil] inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; [Verapamil binds to and results in decreased activity of ABCB1 protein] inhibits the reaction [sodium arsenite promotes the reaction [ABCB1 protein results in increased secretion of calcein AM]]; ABCB1 protein affects the reaction [Mifepristone results in decreased transport of calcein AM]; ABCB1 protein affects the reaction [zosuquidar trihydrochloride results in decreased transport of calcein AM]; Atorvastatin analog inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; chlorpyrifos-methyl affects the reaction [ABCB1 protein results in increased transport of calcein AM]; Cyclosporine inhibits the reaction [ABCB1 protein affects the export of calcein AM]; deoxynivalenol inhibits the reaction [valspodar inhibits the reaction [ABCB1 protein results in increased export of calcein AM]]; Diazinon inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Diazinon promotes the reaction [Endosulfan inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Diazinon promotes the reaction [phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Diazinon promotes the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Diazinon promotes the reaction [Verapamil inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Endosulfan inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Endosulfan inhibits the reaction [phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Endosulfan promotes the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; fenoxycarb inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; fenvalerate inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Lovastatin analog inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; phosalone inhibits the reaction [Endosulfan inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; phosalone inhibits the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; propiconazole inhibits the reaction [phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; propiconazole promotes the reaction [Endosulfan inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; propiconazole promotes the reaction [Verapamil inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Reserpine inhibits the reaction [ABCB1 protein affects the export of calcein AM]; Simvastatin analog inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; sodium arsenite promotes the reaction [ABCB1 protein results in increased secretion of calcein AM]; spinosad inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; valspodar inhibits the reaction [ABCB1 protein results in increased export of calcein AM]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of calcein AM]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Verapamil promotes the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]
calcein AM results in increased activity of ABCB1 protein mutant form
CTD PMID:10617675 PMID:12711602 PMID:15616150 PMID:16121039 PMID:19223659 More... NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
JBrowse link
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 increases transport
multiple interactions
ISO ABCC1 protein results in increased transport of calcein AM
[ABCC1 protein results in increased susceptibility to Silver Nitrate] which results in decreased export of calcein AM; [ABCC1 protein results in increased susceptibility to Silver] which results in decreased export of calcein AM; [MLN 8237 results in decreased activity of ABCC1 protein] which results in decreased export of calcein AM; [MYC protein results in increased expression of ABCC1 protein] which results in increased export of calcein AM; [verlukast results in decreased activity of ABCC1 protein] which results in decreased export of calcein AM; verlukast inhibits the reaction [ABCC1 protein results in increased transport of calcein AM]; zearalenol metabolite inhibits the reaction [ABCC1 protein results in increased transport of calcein AM]; Zearalenone inhibits the reaction [ABCC1 protein results in increased transport of calcein AM]
CTD PMID:19239227 PMID:19647055 PMID:27376922 PMID:34896433 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601
JBrowse link
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 affects transport
multiple interactions
increases transport
increases export
ISO ABCC2 protein affects the transport of calcein AM
Atorvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Lovastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Simvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]
[MYC protein results in increased expression of ABCC2 protein] which results in increased export of calcein AM; Atorvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Lovastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; montelukast inhibits the reaction [ABCC2 protein results in increased export of calcein AM]; Simvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; verlukast inhibits the reaction [ABCC2 protein results in increased export of calcein AM]; verlukast inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; zearalenol inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Zearalenone inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]
CTD PMID:15210835 PMID:15616150 PMID:19239227 PMID:19647055 PMID:19952419 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
JBrowse link
G Abcc3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 affects transport
multiple interactions
increases transport
ISO ABCC3 protein affects the transport of calcein AM
Dexamethasone promotes the reaction [ABCC3 protein affects the transport of calcein AM]; Glutathione promotes the reaction [ABCC3 protein affects the transport of calcein AM]; Hydrocortisone promotes the reaction [ABCC3 protein affects the transport of calcein AM]; Prednisone promotes the reaction [ABCC3 protein affects the transport of calcein AM]; verlukast inhibits the reaction [ABCC3 protein results in increased transport of calcein AM]; zearalenol inhibits the reaction [ABCC3 protein results in increased transport of calcein AM]; Zearalenone inhibits the reaction [ABCC3 protein results in increased transport of calcein AM]
CTD PMID:15210835 PMID:15979871 PMID:19647055 NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823
JBrowse link
G Abcc4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 multiple interactions ISO Glutathione promotes the reaction [ABCC4 protein affects the transport of calcein AM] CTD PMID:15210835 NCBI chr14:118,720,104...118,945,475
Ensembl chr14:118,720,104...118,943,631
JBrowse link
G Abcc6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 multiple interactions ISO Glutathione promotes the reaction [ABCC6 protein affects the transport of calcein AM] CTD PMID:15210835 NCBI chr 7:45,625,804...45,679,915
Ensembl chr 7:45,616,979...45,679,726
JBrowse link
G Myc myelocytomatosis oncogene multiple interactions ISO [MYC protein results in increased expression of ABCC1 protein] which results in increased export of calcein AM; [MYC protein results in increased expression of ABCC2 protein] which results in increased export of calcein AM CTD PMID:19239227 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
JBrowse link
cascade blue term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slco2b1 solute carrier organic anion transporter family, member 2b1 increases uptake
multiple interactions
ISO SLCO2B1 protein results in increased uptake of Cascade Blue
Bleomycin inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Capecitabine inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Docetaxel inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Etoposide inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Irinotecan inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Methotrexate inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Tamoxifen inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Teniposide inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Thiotepa inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]
CTD PMID:30863990 NCBI chr 7:99,307,011...99,360,547
Ensembl chr 7:99,307,011...99,360,547
JBrowse link
coumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aass aminoadipate-semialdehyde synthase decreases expression ISO coumarin results in decreased expression of AASS mRNA CTD PMID:18480146 NCBI chr 6:23,072,172...23,132,985
Ensembl chr 6:23,072,172...23,132,985
JBrowse link
G Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 affects expression ISO coumarin affects the expression of ABCB11 mRNA CTD PMID:16963487 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,960
JBrowse link
G Abcc3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 increases expression ISO coumarin results in increased expression of ABCC3 mRNA CTD PMID:18480146 NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823
JBrowse link
G Acaa1a acetyl-Coenzyme A acyltransferase 1A increases expression ISO coumarin results in increased expression of ACAA1 mRNA CTD PMID:18480146 NCBI chr 9:119,170,094...119,179,361
Ensembl chr 9:119,168,742...119,179,365
JBrowse link
G Acaa2 acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) affects expression ISO coumarin affects the expression of ACAA2 mRNA CTD PMID:16963487 NCBI chr18:74,912,283...74,939,278
Ensembl chr18:74,912,268...74,939,279
JBrowse link
G Ache acetylcholinesterase multiple interactions EXP coumarin inhibits the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; coumarin inhibits the reaction [haloxon results in increased phosphorylation of ACHE protein]; coumarin inhibits the reaction [Paraoxon results in increased phosphorylation of ACHE protein] CTD PMID:10421444 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
JBrowse link
G Acly ATP citrate lyase affects expression ISO coumarin affects the expression of ACLY mRNA CTD PMID:16963487 NCBI chr11:100,367,178...100,418,826
Ensembl chr11:100,367,179...100,418,826
JBrowse link
G Aco1 aconitase 1 affects expression ISO coumarin affects the expression of ACO1 mRNA CTD PMID:16963487 NCBI chr 4:40,143,265...40,199,009
Ensembl chr 4:40,143,081...40,198,338
JBrowse link
G Acot4 acyl-CoA thioesterase 4 increases expression ISO coumarin results in increased expression of ACOT4 mRNA CTD PMID:18480146 NCBI chr12:84,084,028...84,091,497
Ensembl chr12:84,085,153...84,095,375
JBrowse link
G Acsm1 acyl-CoA synthetase medium-chain family member 1 increases expression EXP coumarin results in increased expression of ACSM1 mRNA CTD PMID:17311802 NCBI chr 7:119,216,980...119,261,738
Ensembl chr 7:119,206,249...119,261,738
JBrowse link
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 decreases expression ISO coumarin analog results in decreased expression of AIFM1 mRNA CTD PMID:32578917 NCBI chr  X:47,563,821...47,602,440
Ensembl chr  X:47,563,821...47,602,440
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 increases expression ISO coumarin results in increased expression of AKR1B8 mRNA CTD PMID:18480146 NCBI chr 6:34,331,081...34,345,396
Ensembl chr 6:34,331,054...34,345,398
JBrowse link
G Akr1c6 aldo-keto reductase family 1, member C6 decreases expression ISO coumarin results in decreased expression of AKR1C6 mRNA CTD PMID:18480146 NCBI chr13:4,484,310...4,507,529
Ensembl chr13:4,484,305...4,507,876
JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 affects expression ISO coumarin affects the expression of AKR1D1 mRNA CTD PMID:16963487 NCBI chr 6:37,506,913...37,551,856
Ensembl chr 6:37,507,108...37,545,750
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO coumarin analog results in decreased expression of and results in decreased phosphorylation of AKT1 protein CTD PMID:32578917 NCBI chr12:112,620,255...112,641,318
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 increases expression ISO coumarin results in increased expression of ALDH1A1 mRNA CTD PMID:18480146 NCBI chr19:20,469,947...20,620,827
Ensembl chr19:20,470,079...20,620,829
JBrowse link
G Alox5 arachidonate 5-lipoxygenase increases expression ISO coumarin results in increased expression of ALOX5 mRNA CTD PMID:18480146 NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139
JBrowse link
G Anxa7 annexin A7 increases expression ISO coumarin results in increased expression of ANXA7 mRNA CTD PMID:18480146 NCBI chr14:20,505,329...20,530,268
Ensembl chr14:20,505,328...20,530,201
JBrowse link
G Apbb3 amyloid beta (A4) precursor protein-binding, family B, member 3 decreases expression ISO coumarin results in decreased expression of APBB3 mRNA CTD PMID:18480146 NCBI chr18:36,804,207...36,812,419
Ensembl chr18:36,804,207...36,812,419
JBrowse link
G Apcs amyloid P component, serum decreases expression ISO coumarin results in decreased expression of APCS mRNA CTD PMID:18480146 NCBI chr 1:172,721,528...172,722,621
Ensembl chr 1:172,721,528...172,722,608
JBrowse link
G Arg1 arginase, liver affects expression ISO coumarin affects the expression of ARG1 mRNA CTD PMID:16963487 NCBI chr10:24,791,105...24,803,368
Ensembl chr10:24,791,119...24,803,382
JBrowse link
G Asns asparagine synthetase increases expression ISO coumarin results in increased expression of ASNS mRNA CTD PMID:18480146 NCBI chr 6:7,675,165...7,693,209
Ensembl chr 6:7,675,169...7,693,254
JBrowse link
G Atpif1 ATPase inhibitory factor 1 increases expression ISO coumarin results in increased expression of ATPIF1 mRNA CTD PMID:18480146 NCBI chr 4:132,257,866...132,262,784
Ensembl chr 4:132,257,866...132,260,970
JBrowse link
G Atrn attractin decreases expression ISO coumarin results in decreased expression of ATRN mRNA CTD PMID:18480146 NCBI chr 2:130,734,363...130,872,249
Ensembl chr 2:130,748,415...130,872,253
JBrowse link
G Avpr1a arginine vasopressin receptor 1A decreases expression ISO coumarin results in decreased expression of AVPR1A mRNA CTD PMID:18480146 NCBI chr10:122,284,404...122,289,358
Ensembl chr10:122,284,404...122,289,357
JBrowse link
G Azgp1 alpha-2-glycoprotein 1, zinc affects expression ISO coumarin affects the expression of AZGP1 mRNA CTD PMID:16963487 NCBI chr 5:137,979,783...137,988,495
Ensembl chr 5:137,979,782...137,988,495
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO coumarin analog results in increased expression of BAD mRNA CTD PMID:32578917 NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO coumarin analog results in increased expression of BAK1 protein CTD PMID:31199928 NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983
JBrowse link
G Bax BCL2-associated X protein increases expression ISO coumarin analog results in increased expression of BAX mRNA; coumarin results in increased expression of BAX protein CTD PMID:15964220 PMID:32578917 NCBI chr 7:45,111,119...45,116,344
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bbc3 BCL2 binding component 3 increases expression ISO coumarin analog results in increased expression of BBC3 protein CTD PMID:31199928 NCBI chr 7:16,042,307...16,052,259
Ensembl chr 7:16,042,318...16,052,130
JBrowse link
G Bbox1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 (gamma-butyrobetaine hydroxylase) decreases expression ISO coumarin results in decreased expression of BBOX1 mRNA CTD PMID:18480146 NCBI chr 2:110,094,401...110,145,158
Ensembl chr 2:110,093,042...110,144,905
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO coumarin analog results in decreased expression of BCL2 mRNA; coumarin results in decreased expression of BCL2 protein CTD PMID:15964220 PMID:32578917 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bhlha15 basic helix-loop-helix family, member a15 increases expression ISO coumarin results in increased expression of BHLHA15 mRNA CTD PMID:18480146 NCBI chr 5:144,127,104...144,131,259
Ensembl chr 5:144,127,104...144,131,259
JBrowse link
G Bhmt betaine-homocysteine methyltransferase decreases expression
affects expression
ISO coumarin results in decreased expression of BHMT mRNA
coumarin affects the expression of BHMT mRNA
CTD PMID:16963487 PMID:18480146 NCBI chr13:93,753,399...93,774,266
Ensembl chr13:93,753,183...93,774,469
JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO coumarin analog results in increased expression of BID mRNA CTD PMID:32578917 NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO coumarin analog results in decreased expression of BIRC5 mRNA CTD PMID:32578917 NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569
JBrowse link
G Capn1 calpain 1 decreases expression ISO coumarin analog results in decreased expression of CAPN1 mRNA CTD PMID:32578917 NCBI chr19:6,038,573...6,065,855
Ensembl chr19:6,038,573...6,065,927
JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO coumarin results in decreased activity of CA1 protein CTD PMID:22077347 NCBI chr 3:14,831,274...14,873,425
Ensembl chr 3:14,831,276...14,873,428
JBrowse link
G Car2 carbonic anhydrase 2 increases expression
decreases activity
ISO coumarin results in increased expression of CA2 mRNA
coumarin results in decreased activity of CA2 protein
CTD PMID:18480146 PMID:22077347 NCBI chr 3:14,951,329...14,965,830
Ensembl chr 3:14,951,333...14,965,830
JBrowse link
G Car3 carbonic anhydrase 3 decreases expression ISO coumarin results in decreased expression of CA3 mRNA CTD PMID:18480146 NCBI chr 3:14,928,598...14,937,441
Ensembl chr 3:14,928,572...14,937,583
JBrowse link
G Casp3 caspase 3 increases expression
increases cleavage
ISO coumarin analog results in increased expression of CASP3 mRNA
coumarin analog results in increased cleavage of CASP3 protein
CTD PMID:32578917 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp8 caspase 8 increases expression ISO coumarin analog results in increased expression of CASP8 mRNA CTD PMID:32578917 NCBI chr 1:58,834,398...58,886,662
Ensembl chr 1:58,834,533...58,886,662
JBrowse link
G Casp9 caspase 9 increases expression ISO coumarin analog results in increased expression of CASP9 mRNA CTD PMID:32578917 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Cat catalase multiple interactions
decreases activity
ISO coumarin inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in decreased activity of CAT protein]
coumarin analog results in decreased activity of CAT protein
CTD PMID:21630391 PMID:32578917 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Ccnb2 cyclin B2 decreases expression ISO coumarin results in decreased expression of CCNB2 mRNA CTD PMID:18480146 NCBI chr 9:70,314,971...70,328,836
Ensembl chr 9:70,314,974...70,328,829
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO coumarin analog results in decreased expression of CCND1 mRNA CTD PMID:32578917 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Ccne1 cyclin E1 increases expression
decreases expression
ISO coumarin results in increased expression of CCNE1 mRNA
coumarin analog results in decreased expression of CCNE1 mRNA
CTD PMID:18480146 PMID:32578917 NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959
JBrowse link
G Ccne2 cyclin E2 increases expression ISO coumarin results in increased expression of CCNE2 mRNA CTD PMID:18480146 NCBI chr 4:11,190,489...11,204,779
Ensembl chr 4:11,191,351...11,204,779
JBrowse link
G Cdh1 cadherin 1 increases expression ISO coumarin analog results in increased expression of CDH1 mRNA; coumarin analog results in increased expression of CDH1 protein CTD PMID:32578917 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878
JBrowse link
G Cdh2 cadherin 2 decreases expression ISO coumarin analog results in decreased expression of CDH2 mRNA CTD PMID:32578917 NCBI chr18:16,721,934...16,942,303
Ensembl chr18:16,721,934...16,942,303
JBrowse link
G Cdk2 cyclin-dependent kinase 2 decreases expression ISO coumarin analog results in decreased expression of CDK2 mRNA CTD PMID:32578917 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO coumarin analog results in decreased expression of CDK4 mRNA CTD PMID:32578917 NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) increases expression ISO coumarin analog results in increased expression of CDKN1A mRNA CTD PMID:32578917 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 decreases expression ISO coumarin results in decreased expression of CDKN3 mRNA CTD PMID:18480146 NCBI chr14:46,997,912...47,008,987
Ensembl chr14:46,997,998...47,009,126
JBrowse link
G Cdo1 cysteine dioxygenase 1, cytosolic affects expression ISO coumarin affects the expression of CDO1 mRNA CTD PMID:16963487 NCBI chr18:46,846,260...46,861,569
Ensembl chr18:46,846,260...46,861,462
JBrowse link
G Ces1d carboxylesterase 1D increases expression EXP coumarin results in increased expression of CES1 mRNA CTD PMID:17311802 NCBI chr 8:93,892,700...93,924,432
Ensembl chr 8:93,892,696...93,924,466
JBrowse link
G Cisd3 CDGSH iron sulfur domain 3 increases expression ISO coumarin results in increased expression of CISD3 mRNA CTD PMID:18480146 NCBI chr11:97,576,291...97,579,451
Ensembl chr11:97,576,652...97,579,447
JBrowse link
G Cldn3 claudin 3 decreases expression ISO coumarin analog results in decreased expression of CLDN3 mRNA CTD PMID:32578917 NCBI chr 5:135,015,068...135,016,330
Ensembl chr 5:135,015,068...135,016,326
JBrowse link
G Cldn4 claudin 4 decreases expression ISO coumarin analog results in decreased expression of CLDN4 mRNA CTD PMID:32578917 NCBI chr 5:134,973,977...134,975,788
Ensembl chr 5:134,973,973...134,975,788
JBrowse link
G Coq6 coenzyme Q6 monooxygenase increases expression ISO coumarin results in increased expression of COQ6 mRNA CTD PMID:18480146 NCBI chr12:84,408,530...84,420,570
Ensembl chr12:84,408,431...84,420,570
JBrowse link
G Creg1 cellular repressor of E1A-stimulated genes 1 increases expression ISO coumarin results in increased expression of CREG mRNA CTD PMID:18480146 NCBI chr 1:165,591,327...165,602,878
Ensembl chr 1:165,591,315...165,602,877
JBrowse link
G Creld2 cysteine-rich with EGF-like domains 2 increases expression ISO coumarin results in increased expression of CRELD2 mRNA CTD PMID:18480146 NCBI chr15:88,703,849...88,710,884
Ensembl chr15:88,703,849...88,710,886
JBrowse link
G Cryab crystallin, alpha B decreases expression ISO coumarin results in decreased expression of CRYAB mRNA CTD PMID:18480146 NCBI chr 9:50,657,251...50,667,936
Ensembl chr 9:50,662,625...50,667,936
JBrowse link
G Cryl1 crystallin, lambda 1 increases expression ISO coumarin results in increased expression of CRYL1 mRNA CTD PMID:18480146 NCBI chr14:57,512,491...57,635,940
Ensembl chr14:57,512,450...57,635,986
JBrowse link
G Csad cysteine sulfinic acid decarboxylase decreases expression ISO coumarin results in decreased expression of CSAD mRNA CTD PMID:18480146 NCBI chr15:102,085,432...102,113,487
Ensembl chr15:102,085,434...102,113,159
JBrowse link
G Csrp1 cysteine and glycine-rich protein 1 decreases expression ISO coumarin results in decreased expression of CSRP1 mRNA CTD PMID:18480146 NCBI chr 1:135,614,371...135,679,970
Ensembl chr 1:135,647,799...135,679,970
JBrowse link
G Ctf1 cardiotrophin 1 increases expression ISO coumarin results in increased expression of CTF1 mRNA CTD PMID:18480146 NCBI chr 7:127,311,848...127,317,360
Ensembl chr 7:127,311,908...127,317,364
JBrowse link
G Cth cystathionase (cystathionine gamma-lyase) affects expression ISO coumarin affects the expression of CTH mRNA CTD PMID:16963487 NCBI chr 3:157,599,885...157,630,718
Ensembl chr 3:157,599,885...157,630,714
JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 decreases expression ISO coumarin analog results in decreased expression of CTNNB1 mRNA CTD PMID:32578917 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573
JBrowse link
G Ctsb cathepsin B increases expression ISO coumarin analog results in increased expression of CTSB mRNA CTD PMID:32578917 NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372
JBrowse link
G Cxcl12 chemokine (C-X-C motif) ligand 12 decreases expression ISO coumarin results in decreased expression of CXCL12 mRNA CTD PMID:18480146 NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 decreases expression ISO coumarin analog results in decreased expression of CXCL8 mRNA CTD PMID:32578917 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Cyb561 cytochrome b-561 increases expression ISO coumarin results in increased expression of CYB561 mRNA CTD PMID:18480146 NCBI chr11:105,824,528...105,844,157
Ensembl chr11:105,824,528...105,844,162
JBrowse link
G Cycs cytochrome c, somatic increases expression ISO coumarin analog results in increased expression of CYCS mRNA CTD PMID:32578917 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression
increases metabolic processing
multiple interactions
affects expression
ISO coumarin results in decreased expression of CYP1A2 mRNA
CYP1A2 protein results in increased metabolism of coumarin
[CYP1A2 protein results in increased metabolism of coumarin] which results in increased abundance of 2-hydroxyphenylacetic acid; [CYP1A2 protein results in increased metabolism of coumarin] which results in increased abundance of 7-hydroxycoumarin
coumarin affects the expression of CYP1A2 mRNA
CTD PMID:16963487 PMID:18480146 PMID:34334558 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
JBrowse link
G Cyp2a22 cytochrome P450, family 2, subfamily a, polypeptide 22 increases hydroxylation ISO CYP2A6 protein results in increased hydroxylation of coumarin CTD PMID:12919726 NCBI chr 7:26,631,056...26,638,838
Ensembl chr 7:26,631,056...26,638,809
JBrowse link
G Cyp2a5 cytochrome P450, family 2, subfamily a, polypeptide 5 affects metabolic processing
decreases activity
increases hydroxylation
multiple interactions
increases metabolic processing
affects binding
decreases metabolic processing
EXP
ISO
CYP2A5 protein affects the metabolism of coumarin
coumarin results in decreased activity of CYP2A6 protein
CYP2A6 protein polymorphism results in increased hydroxylation of coumarin; CYP2A6 protein results in increased hydroxylation of coumarin
CYP2A6 promoter SNP affects the metabolism of coumarin; CYP2A6 protein affects the metabolism of coumarin; CYP2A6 protein mutant form affects the metabolism of coumarin
[5-chlorotryptamine analog results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin; [5-fluoro-alpha-methyltryptamine results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin; [5-methyltryptamine analog results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin; [7-methyltryptamine analog results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin; [CYP2A6 protein results in increased metabolism of coumarin] which results in increased chemical synthesis of 7-hydroxycoumarin; [indopan analog results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin; [indopan results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin; [N,N-diisopropyltryptamine analog results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin; [Tranylcypromine results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin; [Tryptamines analog results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin; coumarin inhibits the reaction [CYP2A6 protein results in increased glutathionylation of Lamotrigine]; CYP2A6 protein binds to and results in increased metabolism of coumarin; CYP2A6 protein results in increased metabolism of and affects the abundance of coumarin; Methoxsalen inhibits the reaction [CYP2A6 protein results in increased metabolism of coumarin]; nitrosobenzylmethylamine inhibits the reaction [CYP2A6 protein results in increased hydroxylation of coumarin]; perfluorooctane sulfonic acid inhibits the reaction [CYP2A6 protein results in increased hydroxylation of coumarin]; Proadifen inhibits the reaction [CYP2A6 protein results in increased metabolism of coumarin]; Tranylcypromine inhibits the reaction [CYP2A6 protein results in increased metabolism of coumarin]
CYP2A6 exon SNP results in increased metabolism of coumarin; CYP2A6 protein results in increased metabolism of coumarin
coumarin binds to CYP2A6 protein
CYP2A6 exon SNP results in decreased metabolism of coumarin
CTD PMID:8819299 PMID:10616189 PMID:10646973 PMID:11237731 PMID:11376561 More... NCBI chr 7:26,534,764...26,542,689
Ensembl chr 7:26,534,730...26,542,973
JBrowse link
G Cyp2c52-ps cytochrome P450, family 2, subfamily c, polypeptide 52, pseudogene decreases expression ISO coumarin results in decreased expression of CYP2C mRNA CTD PMID:18480146 NCBI chr19:38,965,106...38,992,071
Ensembl chr19:38,965,091...38,991,733
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 affects response to substance
affects metabolic processing
ISO CYP2C9 protein polymorphism affects the susceptibility to coumarin
CYP2C9 protein polymorphism affects the metabolism of coumarin
CTD PMID:17849045 PMID:23582453 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 affects response to substance
affects metabolic processing
ISO CYP2C9 protein polymorphism affects the susceptibility to coumarin
CYP2C9 protein polymorphism affects the metabolism of coumarin
CTD PMID:17849045 PMID:23582453 NCBI chr19:39,102,342...39,175,200
Ensembl chr19:39,102,342...39,175,516
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects localization
multiple interactions
increases metabolic processing
ISO coumarin affects the localization of CYP2E1 protein
[CYP2E1 protein results in increased metabolism of coumarin] which results in increased abundance of 2-hydroxyphenylacetic acid
CTD PMID:28803882 PMID:34334558 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
JBrowse link
G Cyp51 cytochrome P450, family 51 decreases expression ISO coumarin results in decreased expression of CYP51 mRNA CTD PMID:18480146 NCBI chr 5:4,130,674...4,154,697
Ensembl chr 5:4,131,145...4,154,746
JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 decreases expression ISO coumarin results in decreased expression of CYP7A1 mRNA CTD PMID:18480146 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633
JBrowse link
G Ddit4l DNA-damage-inducible transcript 4-like increases expression ISO coumarin results in increased expression of DDIT4L mRNA CTD PMID:18480146 NCBI chr 3:137,329,433...137,334,093
Ensembl chr 3:137,327,373...137,334,094
JBrowse link
G Ddost dolichyl-di-phosphooligosaccharide-protein glycotransferase increases expression ISO coumarin results in increased expression of DDOST mRNA CTD PMID:18480146 NCBI chr 4:138,032,049...138,039,930
Ensembl chr 4:138,032,041...138,039,939
JBrowse link
G Ddx31 DEAD/H box helicase 31 decreases expression ISO coumarin results in decreased expression of DDX31 mRNA CTD PMID:18480146 NCBI chr 2:28,730,418...28,795,587
Ensembl chr 2:28,730,418...28,795,583
JBrowse link
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 increases expression ISO coumarin results in increased expression of DNAJB11 mRNA CTD PMID:18480146 NCBI chr16:22,676,595...22,698,384
Ensembl chr16:22,676,595...22,698,384
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 affects expression ISO coumarin affects the expression of DNAJB9 mRNA CTD PMID:16963487 NCBI chr12:44,252,680...44,256,851
Ensembl chr12:44,252,342...44,257,109
JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 increases expression ISO coumarin results in increased expression of DNAJC3 mRNA CTD PMID:18480146 NCBI chr14:119,175,344...119,219,114
Ensembl chr14:119,175,388...119,219,109
JBrowse link
G Dscc1 DNA replication and sister chromatid cohesion 1 increases expression ISO coumarin results in increased expression of DSCC1 mRNA CTD PMID:18480146 NCBI chr15:54,939,497...54,953,887
Ensembl chr15:54,939,495...54,953,887
JBrowse link
G Eci1 enoyl-Coenzyme A delta isomerase 1 affects expression ISO coumarin affects the expression of ECI1 mRNA CTD PMID:16963487 NCBI chr17:24,645,657...24,658,290
Ensembl chr17:24,645,615...24,658,322
JBrowse link
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 increases expression ISO coumarin results in increased expression of EEF1E1 mRNA CTD PMID:18480146 NCBI chr13:38,829,667...38,843,004
Ensembl chr13:38,828,183...38,843,034
JBrowse link
G Ell3 elongation factor RNA polymerase II-like 3 increases expression ISO coumarin results in increased expression of ELL3 mRNA CTD PMID:18480146 NCBI chr 2:121,269,508...121,273,082
Ensembl chr 2:121,269,491...121,274,759
JBrowse link
G Eme2 essential meiotic structure-specific endonuclease subunit 2 increases expression ISO coumarin results in increased expression of EME2 mRNA CTD PMID:18480146 NCBI chr17:25,111,126...25,114,061
Ensembl chr17:25,107,460...25,114,061
JBrowse link
G Ephx1 epoxide hydrolase 1, microsomal increases expression EXP coumarin results in increased expression of EPHX1 mRNA CTD PMID:17311802 NCBI chr 1:180,817,121...180,845,134
Ensembl chr 1:180,803,775...180,848,469
JBrowse link
G F9 coagulation factor IX increases response to substance ISO F9 exon polymorphism results in increased susceptibility to coumarin; F9 protein mutant form results in increased susceptibility to coumarin CTD PMID:11307814 NCBI chr  X:59,044,675...59,076,120
Ensembl chr  X:59,044,824...59,076,119
JBrowse link
G Fads1 fatty acid desaturase 1 decreases expression ISO coumarin results in decreased expression of FADS1 mRNA CTD PMID:18480146 NCBI chr19:10,160,245...10,174,238
Ensembl chr19:10,160,252...10,174,241
JBrowse link
G Fam111a family with sequence similarity 111, member A increases expression ISO coumarin results in increased expression of FAM111A mRNA CTD PMID:18480146 NCBI chr19:12,550,874...12,567,133
Ensembl chr19:12,523,104...12,567,132
JBrowse link
G Fasn fatty acid synthase affects expression ISO coumarin affects the expression of FASN mRNA CTD PMID:16963487 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373
JBrowse link
G Fen1 flap structure specific endonuclease 1 increases expression ISO coumarin results in increased expression of FEN1 mRNA CTD PMID:18480146 NCBI chr19:10,176,496...10,181,757
Ensembl chr19:10,176,496...10,181,533
JBrowse link
G Fgg fibrinogen gamma chain affects expression ISO coumarin affects the expression of FGG mRNA CTD PMID:16963487 NCBI chr 3:82,915,031...82,922,363
Ensembl chr 3:82,915,031...82,922,356
JBrowse link
G Fggy FGGY carbohydrate kinase domain containing decreases expression ISO coumarin results in decreased expression of FGGY mRNA CTD PMID:18480146 NCBI chr 4:95,445,717...95,815,176
Ensembl chr 4:95,445,744...95,815,176
JBrowse link
G Fkbp11 FK506 binding protein 11 increases expression ISO coumarin results in increased expression of FKBP11 mRNA CTD PMID:18480146 NCBI chr15:98,622,249...98,626,079
Ensembl chr15:98,622,247...98,626,079
JBrowse link
G Fmo1 flavin containing monooxygenase 1 decreases expression ISO coumarin results in decreased expression of FMO1 mRNA CTD PMID:18480146 NCBI chr 1:162,657,130...162,694,179
Ensembl chr 1:162,657,130...162,694,179
JBrowse link
G Gas5 growth arrest specific 5 increases expression ISO coumarin results in increased expression of GAS5 mRNA CTD PMID:18480146 NCBI chr 1:160,862,171...160,866,109
Ensembl chr 1:160,861,992...160,866,109
JBrowse link
G Gckr glucokinase regulatory protein decreases expression ISO coumarin results in decreased expression of GCKR mRNA CTD PMID:18480146 NCBI chr 5:31,454,594...31,484,646
Ensembl chr 5:31,454,787...31,484,658
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO coumarin results in increased expression of GCLC mRNA CTD PMID:18480146 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression ISO coumarin results in increased expression of GCLM mRNA CTD PMID:18480146 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381
JBrowse link
G Gjb2 gap junction protein, beta 2 increases expression ISO coumarin results in increased expression of GJB2 mRNA CTD PMID:18480146 NCBI chr14:57,336,059...57,342,159
Ensembl chr14:57,336,057...57,342,159
JBrowse link
G Gk glycerol kinase decreases expression ISO coumarin results in decreased expression of GK mRNA CTD PMID:18480146 NCBI chr  X:84,745,543...84,820,425
Ensembl chr  X:84,745,543...84,820,425
JBrowse link
G Glb1 galactosidase, beta 1 increases expression ISO coumarin results in increased expression of GLB1 mRNA CTD PMID:18480146 NCBI chr 9:114,230,146...114,303,447
Ensembl chr 9:114,230,144...114,303,966
JBrowse link
G Gldc glycine decarboxylase decreases expression ISO coumarin results in decreased expression of GLDC mRNA CTD PMID:18480146 NCBI chr19:30,075,841...30,152,841
Ensembl chr19:30,075,847...30,152,829
JBrowse link
G Gm715 predicted gene 715 increases expression ISO coumarin results in increased expression of RGD1560171 mRNA CTD PMID:18480146 NCBI chr  X:59,591,614...59,592,823
Ensembl chr  X:59,591,614...59,592,823
JBrowse link
G Gpr108 G protein-coupled receptor 108 decreases expression ISO coumarin results in decreased expression of GPR108 mRNA CTD PMID:18480146 NCBI chr17:57,541,914...57,555,743
Ensembl chr17:57,541,635...57,555,446
JBrowse link
G Gpx1 glutathione peroxidase 1 affects expression ISO coumarin affects the expression of GPX1 mRNA CTD PMID:16963487 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542
JBrowse link
G Gsr glutathione reductase increases expression ISO coumarin results in increased expression of GSR mRNA CTD PMID:18480146 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
JBrowse link
G Gsta1 glutathione S-transferase, alpha 1 (Ya) increases expression ISO
EXP
coumarin results in increased expression of GSTA5 protein
coumarin results in increased expression of GSTA1 protein
CTD PMID:9794803 PMID:11309284 NCBI chr 9:78,137,951...78,149,965
Ensembl chr 9:78,137,938...78,149,966
JBrowse link
G Gsta2 glutathione S-transferase, alpha 2 (Yc2) increases expression EXP coumarin results in increased expression of GSTA2 protein CTD PMID:11309284 NCBI chr 9:78,238,300...78,254,474
Ensembl chr 9:78,238,300...78,263,070
JBrowse link
G Gsta3 glutathione S-transferase, alpha 3 increases expression EXP
ISO
coumarin results in increased expression of GSTA3 protein CTD PMID:9794803 PMID:11309284 NCBI chr 1:21,310,789...21,335,799
Ensembl chr 1:21,310,813...21,335,885
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO
EXP
coumarin results in increased expression of GSTM3 protein
coumarin results in increased expression of GSTM5 protein
CTD PMID:9794803 PMID:11309284 NCBI chr 3:107,803,170...107,806,001
Ensembl chr 3:107,803,137...107,806,002
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 increases expression EXP
ISO
coumarin results in increased expression of GSTP1 protein CTD PMID:9794803 PMID:11309284 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
JBrowse link
G Gstp2 glutathione S-transferase, pi 2 increases expression EXP coumarin results in increased expression of GSTP2 protein CTD PMID:11309284 NCBI chr19:4,090,288...4,092,221
Ensembl chr19:4,090,285...4,096,023
JBrowse link
G Gstt1 glutathione S-transferase, theta 1 increases expression ISO coumarin results in increased expression of GSTT1 mRNA; coumarin results in increased expression of GSTT1 protein CTD PMID:9794803 PMID:9855024 PMID:10413528 NCBI chr10:75,619,647...75,634,418
Ensembl chr10:75,619,647...75,634,418
JBrowse link
G H2-Aa histocompatibility 2, class II antigen A, alpha increases expression ISO coumarin results in increased expression of RT1-BA mRNA CTD PMID:18480146 NCBI chr17:34,501,718...34,506,797
Ensembl chr17:34,501,718...34,506,797
JBrowse link
G H2-DMa histocompatibility 2, class II, locus DMa increases expression ISO coumarin results in increased expression of HLA-DMA mRNA CTD PMID:18480146 NCBI chr17:34,338,667...34,358,075
Ensembl chr17:34,338,515...34,358,075
JBrowse link
G Hal histidine ammonia lyase decreases expression ISO coumarin results in decreased expression of HAL mRNA CTD PMID:18480146 NCBI chr10:93,324,630...93,352,623
Ensembl chr10:93,324,630...93,355,166
JBrowse link
G Hao2 hydroxyacid oxidase 2 decreases expression ISO coumarin results in decreased expression of HAO2 mRNA CTD PMID:18480146 NCBI chr 3:98,781,835...98,802,692
Ensembl chr 3:98,781,837...98,800,555
JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 multiple interactions ISO coumarin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased glycosylation of HBA1 protein] CTD PMID:19647726 NCBI chr11:32,246,492...32,247,310
Ensembl chr11:32,246,489...32,247,298
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit increases expression ISO coumarin analog results in increased expression of HIF1A mRNA CTD PMID:32578917 NCBI chr12:73,948,098...73,994,328
Ensembl chr12:73,948,149...73,994,304
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase increases expression ISO coumarin results in increased expression of HMGCR mRNA CTD PMID:18480146 NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444
JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 multiple interactions ISO coumarin analog inhibits the reaction [[HSD17B1 protein co-treated with NADP] results in increased reduction of Estrone] CTD PMID:21232530 NCBI chr11:100,968,792...100,972,014
Ensembl chr11:100,969,237...100,971,353
JBrowse link
G Hsp90b1 heat shock protein 90, beta (Grp94), member 1 increases expression ISO coumarin results in increased expression of HSP90B1 mRNA CTD PMID:18480146 NCBI chr10:86,526,705...86,541,308
Ensembl chr10:86,526,073...86,541,373
JBrowse link
G Hspa1b heat shock protein 1B increases expression ISO coumarin results in increased expression of HSPA1B mRNA CTD PMID:18480146 NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214
JBrowse link
G Hyou1 hypoxia up-regulated 1 increases expression ISO coumarin results in increased expression of HYOU1 mRNA CTD PMID:18480146 NCBI chr 9:44,290,787...44,303,666
Ensembl chr 9:44,290,787...44,303,666
JBrowse link
G Igfals insulin-like growth factor binding protein, acid labile subunit decreases expression ISO coumarin results in decreased expression of IGFALS mRNA CTD PMID:18480146 NCBI chr17:25,096,818...25,100,985
Ensembl chr17:25,084,971...25,100,984
JBrowse link
G Il1b interleukin 1 beta increases expression
decreases expression
ISO coumarin results in increased expression of IL1B mRNA
coumarin analog results in decreased expression of IL1B protein
CTD PMID:15135310 PMID:32578917 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il6 interleukin 6 increases expression
decreases expression
ISO coumarin results in increased expression of IL6 mRNA
coumarin analog results in decreased expression of IL6 mRNA; coumarin analog results in decreased expression of IL6 protein
CTD PMID:15135310 PMID:32578917 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Isyna1 myo-inositol 1-phosphate synthase A1 increases expression ISO coumarin results in increased expression of ISYNA1 mRNA CTD PMID:18480146 NCBI chr 8:71,047,131...71,049,940
Ensembl chr 8:71,047,023...71,049,940
JBrowse link
G Josd2 Josephin domain containing 2 increases expression ISO coumarin results in increased expression of JOSD2 mRNA CTD PMID:18480146 NCBI chr 7:44,117,404...44,121,082
Ensembl chr 7:44,117,404...44,121,086
JBrowse link
G Kcnk2 potassium channel, subfamily K, member 2 increases expression ISO coumarin results in increased expression of KCNK2 mRNA CTD PMID:18480146 NCBI chr 1:188,940,127...189,134,979
Ensembl chr 1:188,940,127...189,134,470
JBrowse link
G Kdr kinase insert domain protein receptor increases expression ISO coumarin analog results in increased expression of KDR mRNA CTD PMID:32578917 NCBI chr 5:76,093,487...76,139,885
Ensembl chr 5:76,093,487...76,139,118
JBrowse link
G Kif20a kinesin family member 20A decreases expression ISO coumarin results in decreased expression of KIF20A mRNA CTD PMID:18480146 NCBI chr18:34,757,677...34,766,330
Ensembl chr18:34,757,666...34,766,330
JBrowse link
G Klf2 Kruppel-like factor 2 (lung) decreases expression ISO coumarin results in decreased expression of KLF2 mRNA CTD PMID:18480146 NCBI chr 8:73,072,906...73,075,498
Ensembl chr 8:73,072,877...73,075,500
JBrowse link
G Krt19 keratin 19 decreases expression ISO coumarin results in decreased expression of KRT19 mRNA CTD PMID:18480146 NCBI chr11:100,031,636...100,036,752
Ensembl chr11:100,031,636...100,039,491
JBrowse link
G Kynu kynureninase decreases expression ISO coumarin results in decreased expression of KYNU mRNA CTD PMID:18480146 NCBI chr 2:43,445,270...43,573,060
Ensembl chr 2:43,445,341...43,572,727
JBrowse link
G Lad1 ladinin increases expression ISO coumarin results in increased expression of LAD1 mRNA CTD PMID:18480146 NCBI chr 1:135,746,336...135,761,079
Ensembl chr 1:135,746,336...135,761,080
JBrowse link
G Lmf2 lipase maturation factor 2 increases expression ISO coumarin results in increased expression of LMF2 mRNA CTD PMID:18480146 NCBI chr15:89,235,207...89,239,862
Ensembl chr15:89,235,207...89,239,862
JBrowse link
G Lrp3 low density lipoprotein receptor-related protein 3 affects expression ISO coumarin affects the expression of LRP3 mRNA CTD PMID:16963487 NCBI chr 7:34,900,303...34,914,791
Ensembl chr 7:34,899,452...34,914,923
JBrowse link
G Mat1a methionine adenosyltransferase I, alpha affects expression ISO coumarin affects the expression of MAT1A mRNA CTD PMID:16963487 NCBI chr14:40,826,969...40,846,385
Ensembl chr14:40,826,992...40,846,369
JBrowse link
G Mbl2 mannose-binding lectin (protein C) 2 decreases expression ISO coumarin results in decreased expression of MBL2 mRNA CTD PMID:18480146 NCBI chr19:30,210,306...30,217,087
Ensembl chr19:30,210,342...30,217,087
JBrowse link
G Mcm2 minichromosome maintenance complex component 2 increases expression ISO coumarin results in increased expression of MCM2 mRNA CTD PMID:18480146 NCBI chr 6:88,860,456...88,875,762
Ensembl chr 6:88,860,456...88,875,762
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO coumarin results in increased expression of MCM3 mRNA CTD PMID:18480146 NCBI chr 1:20,873,188...20,890,536
Ensembl chr 1:20,873,192...20,890,536
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 increases expression ISO coumarin results in increased expression of MCM4 mRNA CTD PMID:18480146 NCBI chr16:15,441,761...15,455,264
Ensembl chr16:15,441,761...15,455,264
JBrowse link
G Mcm5 minichromosome maintenance complex component 5 increases expression ISO coumarin results in increased expression of MCM5 mRNA CTD PMID:18480146 NCBI chr 8:75,836,096...75,855,067
Ensembl chr 8:75,836,197...75,855,067
JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 decreases expression ISO coumarin analog results in decreased expression of MDM2 mRNA CTD PMID:32578917 NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663
JBrowse link
G Mgp matrix Gla protein decreases expression ISO
EXP
coumarin results in decreased expression of MGP mRNA CTD PMID:19350115 NCBI chr 6:136,849,433...136,852,821
Ensembl chr 6:136,849,433...136,852,821
JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 increases expression ISO coumarin results in increased expression of MGST2 mRNA CTD PMID:18480146 NCBI chr 3:51,544,179...51,590,096
Ensembl chr 3:51,567,781...51,590,098
JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 decreases expression ISO coumarin results in decreased expression of MGST3 mRNA CTD PMID:18480146 NCBI chr 1:167,199,535...167,221,410
Ensembl chr 1:167,199,535...167,221,410
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO coumarin analog results in decreased expression of MMP2 mRNA CTD PMID:32578917 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
ISO coumarin analog results in decreased expression of and results in decreased activity of MMP9 protein
coumarin analog results in decreased expression of MMP9 mRNA
CTD PMID:32578917 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
JBrowse link
G Mms22l MMS22-like, DNA repair protein increases expression ISO coumarin results in increased expression of MMS22L mRNA CTD PMID:18480146 NCBI chr 4:24,496,451...24,602,950
Ensembl chr 4:24,496,451...24,602,950
JBrowse link
G Msmo1 methylsterol monoxygenase 1 affects expression ISO coumarin affects the expression of MSMO1 mRNA CTD PMID:16963487 NCBI chr 8:65,171,157...65,186,822
Ensembl chr 8:65,171,173...65,186,826
JBrowse link
G Mt1 metallothionein 1 increases expression ISO coumarin results in increased expression of MT1A mRNA CTD PMID:18480146 NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955
JBrowse link
G Mt2 metallothionein 2 increases expression ISO coumarin results in increased expression of MT2A mRNA CTD PMID:18480146 NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196
JBrowse link
G Nectin2 nectin cell adhesion molecule 2 decreases expression ISO coumarin results in decreased expression of NECTIN2 mRNA CTD PMID:18480146 NCBI chr 7:19,450,569...19,483,498
Ensembl chr 7:19,450,569...19,484,408
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 affects activity
increases activity
EXP coumarin affects the activity of NFE2L2 protein
coumarin results in increased activity of NFE2L2 protein
CTD PMID:11309284 PMID:30114225 PMID:30203046 NCBI chr 2:75,505,857...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nol3 nucleolar protein 3 (apoptosis repressor with CARD domain) increases expression ISO coumarin results in increased expression of NOL3 mRNA CTD PMID:18480146 NCBI chr 8:106,002,777...106,008,571
Ensembl chr 8:106,002,772...106,008,571
JBrowse link
G Nol8 nucleolar protein 8 increases expression ISO coumarin results in increased expression of NOL8 mRNA CTD PMID:18480146 NCBI chr13:49,806,554...49,832,492
Ensembl chr13:49,806,554...49,832,492
JBrowse link
G Nop56 NOP56 ribonucleoprotein increases expression ISO coumarin results in increased expression of NOP56 mRNA CTD PMID:18480146 NCBI chr 2:130,112,904...130,121,233
Ensembl chr 2:130,116,350...130,121,233
JBrowse link
G Nos2 nitric oxide synthase 2, inducible increases expression ISO coumarin results in increased expression of NOS2 mRNA
coumarin analog results in increased expression of NOS2 mRNA; coumarin analog results in increased expression of NOS2 protein
CTD PMID:15135310 PMID:32578917 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression EXP
ISO
coumarin results in increased expression of NQO1 mRNA; coumarin results in increased expression of NQO1 protein CTD PMID:11309284 PMID:17311802 PMID:18480146 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO coumarin results in increased expression of NR0B2 mRNA CTD PMID:18480146 NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847
JBrowse link
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 increases expression ISO coumarin results in increased expression of NR1D2 mRNA CTD PMID:18480146 NCBI chr14:4,230,549...4,265,640
Ensembl chr14:4,230,569...4,265,642
JBrowse link
G Nrep neuronal regeneration related protein decreases expression ISO coumarin results in decreased expression of NREP mRNA CTD PMID:18480146 NCBI chr18:33,570,072...33,597,444
Ensembl chr18:33,570,072...33,597,082
JBrowse link
G Nrtn neurturin increases expression ISO coumarin results in increased expression of NRTN mRNA CTD PMID:18480146 NCBI chr17:57,058,323...57,064,548
Ensembl chr17:57,058,325...57,064,530
JBrowse link
G Ntng1 netrin G1 decreases expression ISO coumarin results in decreased expression of NTNG1 mRNA CTD PMID:18480146 NCBI chr 3:109,687,366...110,057,291
Ensembl chr 3:109,687,356...110,051,327
JBrowse link
G Nupr1 nuclear protein transcription regulator 1 increases expression ISO coumarin results in increased expression of NUPR1 mRNA CTD PMID:18480146 NCBI chr 7:126,222,418...126,224,642
Ensembl chr 7:126,222,421...126,230,033
JBrowse link
G Oaf out at first homolog decreases expression ISO coumarin results in decreased expression of OAF mRNA CTD PMID:18480146 NCBI chr 9:43,132,575...43,151,113
Ensembl chr 9:43,132,532...43,151,208
JBrowse link
G Oat ornithine aminotransferase decreases expression ISO coumarin results in decreased expression of OAT mRNA CTD PMID:18480146 NCBI chr 7:132,159,204...132,178,127
Ensembl chr 7:132,159,207...132,178,127
JBrowse link
G Ogn osteoglycin decreases expression ISO coumarin results in decreased expression of OGN mRNA CTD PMID:18480146 NCBI chr13:49,761,491...49,777,977
Ensembl chr13:49,761,522...49,777,977
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 decreases activity
decreases expression
increases cleavage
multiple interactions
ISO coumarin results in decreased activity of PARP1 protein
coumarin analog results in decreased expression of PARP1 mRNA
coumarin analog results in increased cleavage of PARP1 protein
[coumarin results in decreased activity of PARP1 protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased abundance of NAD]; [coumarin results in decreased activity of PARP1 protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased abundance of NADP]
CTD PMID:17669606 PMID:31199928 PMID:32578917 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) increases expression ISO coumarin results in increased expression of PCK2 mRNA CTD PMID:18480146 NCBI chr14:55,777,721...55,787,477
Ensembl chr14:55,777,723...55,788,699
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO coumarin analog results in increased expression of PCNA mRNA CTD PMID:32578917 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
JBrowse link
G Pde4b phosphodiesterase 4B, cAMP specific decreases expression ISO coumarin results in decreased expression of PDE4B mRNA CTD PMID:18480146 NCBI chr 4:101,944,529...102,464,472
Ensembl chr 4:101,944,740...102,464,456
JBrowse link
G Pdia3 protein disulfide isomerase associated 3 increases expression ISO coumarin results in increased expression of PDIA3 mRNA CTD PMID:18480146 NCBI chr 2:121,244,383...121,269,168
Ensembl chr 2:121,244,256...121,269,168
JBrowse link
G Pdia4 protein disulfide isomerase associated 4 increases expression ISO coumarin results in increased expression of PDIA4 mRNA CTD PMID:18480146 NCBI chr 6:47,773,075...47,790,446
Ensembl chr 6:47,773,075...47,790,364
JBrowse link
G Pdk2 pyruvate dehydrogenase kinase, isoenzyme 2 decreases expression ISO coumarin results in decreased expression of PDK2 mRNA CTD PMID:18480146 NCBI chr11:94,917,084...94,932,197
Ensembl chr11:94,917,084...94,932,180
JBrowse link
G Pla2g12a phospholipase A2, group XIIA increases expression ISO coumarin results in increased expression of PLA2G12A mRNA CTD PMID:18480146 NCBI chr 3:129,672,255...129,689,474
Ensembl chr 3:129,672,255...129,689,474
JBrowse link
G Pold1 polymerase (DNA directed), delta 1, catalytic subunit increases expression ISO coumarin results in increased expression of POLD1 mRNA CTD PMID:18480146 NCBI chr 7:44,182,168...44,198,239
Ensembl chr 7:44,182,170...44,198,273
JBrowse link
G Pold2 polymerase (DNA directed), delta 2, regulatory subunit increases expression ISO coumarin results in increased expression of POLD2 mRNA CTD PMID:18480146 NCBI chr11:5,822,180...5,828,256
Ensembl chr11:5,822,180...5,828,292
JBrowse link
G Polr1e polymerase (RNA) I polypeptide E increases expression ISO coumarin results in increased expression of POLR1E mRNA CTD PMID:18480146 NCBI chr 4:45,018,609...45,034,279
Ensembl chr 4:45,018,583...45,036,565
JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression ISO coumarin results in increased expression of PTGR1 mRNA CTD PMID:18480146 NCBI chr 4:58,965,590...58,987,131
Ensembl chr 4:58,965,439...58,987,119
JBrowse link
G R3hdm1 R3H domain containing 1 increases expression ISO coumarin results in increased expression of R3HDM1 mRNA CTD PMID:18480146 NCBI chr 1:128,031,016...128,165,475
Ensembl chr 1:128,031,038...128,165,473
JBrowse link
G R3hdm2 R3H domain containing 2 decreases expression ISO coumarin results in decreased expression of R3HDM2 mRNA CTD PMID:18480146 NCBI chr10:127,216,201...127,335,253
Ensembl chr10:127,216,196...127,335,253
JBrowse link
G Rab3d RAB3D, member RAS oncogene family increases expression ISO coumarin results in increased expression of RAB3D mRNA CTD PMID:18480146 NCBI chr 9:21,818,787...21,829,623
Ensembl chr 9:21,818,787...21,829,488
JBrowse link
G Rbm3 RNA binding motif (RNP1, RRM) protein 3 increases expression ISO coumarin results in increased expression of RBM3 mRNA CTD PMID:18480146 NCBI chr  X:8,005,214...8,012,119
Ensembl chr  X:8,005,214...8,012,119
JBrowse link
G Rbp1 retinol binding protein 1, cellular decreases expression ISO coumarin results in decreased expression of RBP1 mRNA CTD PMID:18480146 NCBI chr 9:98,305,014...98,328,604
Ensembl chr 9:98,305,014...98,328,628
JBrowse link
G Rgn regucalcin decreases expression ISO coumarin results in decreased expression of RGN mRNA CTD PMID:18480146 NCBI chr  X:20,416,005...20,428,328
Ensembl chr  X:20,416,026...20,428,328
JBrowse link
G Rgs8 regulator of G-protein signaling 8 decreases expression ISO coumarin results in decreased expression of RGS8 mRNA CTD PMID:18480146 NCBI chr 1:153,528,612...153,573,415
Ensembl chr 1:153,528,771...153,576,069
JBrowse link
G Rprm reprimo, TP53 dependent G2 arrest mediator candidate decreases expression ISO coumarin results in decreased expression of RPRM mRNA CTD PMID:18480146 NCBI chr 2:53,974,105...53,975,564
Ensembl chr 2:53,974,105...53,975,564
JBrowse link
G Saraf store-operated calcium entry-associated regulatory factor increases expression ISO coumarin results in increased expression of SARAF mRNA CTD PMID:18480146 NCBI chr 8:34,621,733...34,638,001
Ensembl chr 8:34,621,717...34,637,999
JBrowse link
G Scd1 stearoyl-Coenzyme A desaturase 1 decreases expression ISO coumarin results in decreased expression of SCD1 mRNA CTD PMID:18480146 NCBI chr19:44,382,889...44,396,148
Ensembl chr19:44,382,894...44,396,318
JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 increases expression ISO coumarin results in increased expression of SDF2L1 mRNA CTD PMID:18480146 NCBI chr16:16,948,002...16,950,247
Ensembl chr16:16,948,002...16,950,247
JBrowse link
G Sel1l sel-1 suppressor of lin-12-like (C. elegans) increases expression ISO coumarin results in increased expression of SEL1L mRNA CTD PMID:18480146 NCBI chr12:91,772,817...91,815,931
Ensembl chr12:91,772,817...91,815,931
JBrowse link
G Sema6d sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D increases expression ISO coumarin results in increased expression of SEMA6D mRNA CTD PMID:18480146 NCBI chr 2:123,931,089...124,509,709
Ensembl chr 2:123,931,889...124,509,690
JBrowse link
G Slc17a1 solute carrier family 17 (sodium phosphate), member 1 increases expression ISO coumarin results in increased expression of SLC17A1 mRNA CTD PMID:18480146 NCBI chr13:24,051,607...24,079,713
Ensembl chr13:24,051,733...24,079,713
JBrowse link
G Slc17a3 solute carrier family 17 (sodium phosphate), member 3 increases expression ISO coumarin results in increased expression of SLC17A3 mRNA CTD PMID:18480146 NCBI chr13:24,020,905...24,044,701
Ensembl chr13:24,023,417...24,044,699
JBrowse link
G Slc1a2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 increases expression ISO coumarin results in increased expression of SLC1A2 mRNA CTD PMID:18480146 NCBI chr 2:102,488,584...102,621,129
Ensembl chr 2:102,489,004...102,621,129
JBrowse link
G Slc27a2 solute carrier family 27 (fatty acid transporter), member 2 affects expression ISO coumarin affects the expression of SLC27A2 mRNA CTD PMID:16963487 NCBI chr 2:126,394,944...126,430,163
Ensembl chr 2:126,394,327...126,430,163
JBrowse link
G Slc28a2 solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 decreases expression ISO coumarin results in decreased expression of SLC28A2 mRNA CTD PMID:18480146 NCBI chr 2:122,256,836...122,291,633
Ensembl chr 2:122,256,958...122,291,618
JBrowse link
G Slc35e3 solute carrier family 35, member E3 increases expression ISO coumarin results in increased expression of SLC35E3 mRNA CTD PMID:18480146 NCBI chr10:117,569,583...117,582,263
Ensembl chr10:117,569,584...117,582,270
JBrowse link
G Slc6a13 solute carrier family 6 (neurotransmitter transporter, GABA), member 13 decreases expression ISO coumarin results in decreased expression of SLC6A13 mRNA CTD PMID:18480146 NCBI chr 6:121,277,184...121,314,680
Ensembl chr 6:121,277,186...121,314,692
JBrowse link
G Slc6a9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 increases expression ISO coumarin results in increased expression of SLC6A9 mRNA CTD PMID:18480146 NCBI chr 4:117,692,240...117,726,502
Ensembl chr 4:117,691,703...117,732,395
JBrowse link
G Smpdl3b sphingomyelin phosphodiesterase, acid-like 3B increases expression ISO coumarin results in increased expression of SMPDL3B mRNA CTD PMID:18480146 NCBI chr 4:132,460,277...132,484,558
Ensembl chr 4:132,460,277...132,484,563
JBrowse link
G Snai2 snail family zinc finger 2 decreases expression ISO coumarin analog results in decreased expression of SNAI2 mRNA CTD PMID:32578917 NCBI chr16:14,523,716...14,527,259
Ensembl chr16:14,523,716...14,527,249
JBrowse link
G Srxn1 sulfiredoxin 1 homolog (S. cerevisiae) increases expression ISO coumarin results in increased expression of SRXN1 mRNA CTD PMID:18480146 NCBI chr 2:151,946,738...151,953,296
Ensembl chr 2:151,947,436...151,953,296
JBrowse link
G Stat5b signal transducer and activator of transcription 5B increases activity EXP coumarin results in increased activity of STAT5B protein CTD PMID:30114225 NCBI chr11:100,671,557...100,741,407
Ensembl chr11:100,671,557...100,741,550
JBrowse link
G Sult1b1 sulfotransferase family 1B, member 1 affects expression ISO coumarin affects the expression of SULT1B1 mRNA CTD PMID:16963487 NCBI chr 5:87,661,186...87,686,054
Ensembl chr 5:87,661,198...87,686,054
JBrowse link
G Sult1c1 sulfotransferase family, cytosolic, 1C, member 1 decreases expression ISO coumarin results in decreased expression of SULT1C1 mRNA CTD PMID:18480146 NCBI chr17:54,268,643...54,297,659
Ensembl chr17:54,268,643...54,297,702
JBrowse link
G Sult1e1 sulfotransferase family 1E, member 1 decreases expression ISO coumarin results in decreased expression of SULT1E1 mRNA CTD PMID:18480146 NCBI chr 5:87,723,827...87,739,470
Ensembl chr 5:87,723,828...87,739,453
JBrowse link
G Sycp3 synaptonemal complex protein 3 decreases expression ISO coumarin results in decreased expression of SYCP3 mRNA CTD PMID:18480146 NCBI chr10:88,295,449...88,309,098
Ensembl chr10:88,295,431...88,309,098
JBrowse link
G Syne4 spectrin repeat containing, nuclear envelope family member 4 increases expression ISO coumarin results in increased expression of SYNE4 mRNA CTD PMID:18480146 NCBI chr 7:30,014,241...30,018,470
Ensembl chr 7:30,014,232...30,018,471
JBrowse link
G Tfrc transferrin receptor increases expression ISO coumarin results in increased expression of TFRC mRNA CTD PMID:18480146 NCBI chr16:32,427,714...32,451,612
Ensembl chr16:32,427,738...32,451,612
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO coumarin analog results in increased expression of TGFB1 mRNA CTD PMID:32578917 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Thra thyroid hormone receptor alpha increases expression ISO coumarin results in increased expression of THRA mRNA CTD PMID:18480146 NCBI chr11:98,631,539...98,659,832
Ensembl chr11:98,631,464...98,659,832
JBrowse link
G Thrsp thyroid hormone responsive affects expression
decreases expression
ISO coumarin affects the expression of THRSP mRNA
coumarin results in decreased expression of THRSP mRNA
CTD PMID:16963487 PMID:18480146 NCBI chr 7:97,062,140...97,066,757
Ensembl chr 7:97,062,145...97,066,937
JBrowse link
G Timp2 tissue inhibitor of metalloproteinase 2 increases expression ISO coumarin analog results in increased expression of TIMP2 mRNA CTD PMID:32578917 NCBI chr11:118,191,887...118,246,237
Ensembl chr11:118,191,895...118,246,566
JBrowse link
G Timp4 tissue inhibitor of metalloproteinase 4 increases expression ISO coumarin analog results in increased expression of TIMP4 mRNA CTD PMID:32578917 NCBI chr 6:115,221,405...115,229,166
Ensembl chr 6:115,218,853...115,229,166
JBrowse link
G Tmed3 transmembrane p24 trafficking protein 3 increases expression ISO coumarin results in increased expression of TMED3 mRNA CTD PMID:18480146 NCBI chr 9:89,581,256...89,587,096
Ensembl chr 9:89,581,259...89,587,121
JBrowse link
G Tnf tumor necrosis factor increases expression ISO coumarin results in increased expression of TNF mRNA
coumarin analog results in increased expression of TNF protein
CTD PMID:15135310 PMID:32578917 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 decreases expression ISO coumarin results in decreased expression of TNFRSF9 mRNA CTD PMID:18480146 NCBI chr 4:151,004,612...151,030,561
Ensembl chr 4:150,999,019...151,030,559
JBrowse link
G Tradd TNFRSF1A-associated via death domain increases expression ISO coumarin analog results in increased expression of TRADD mRNA CTD PMID:32578917 NCBI chr 8:105,985,207...105,991,226
Ensembl chr 8:105,984,918...105,991,241
JBrowse link
G Trp53 transformation related protein 53 increases expression ISO coumarin analog results in increased expression of TP53 mRNA; coumarin analog results in increased expression of TP53 protein CTD PMID:32578917 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Trpc2 transient receptor potential cation channel, subfamily C, member 2 increases expression ISO coumarin results in increased expression of TRPC2 mRNA CTD PMID:18480146 NCBI chr 7:101,732,323...101,746,071
Ensembl chr 7:101,732,323...101,745,603
JBrowse link
G Tsc22d1 TSC22 domain family, member 1 decreases expression ISO coumarin results in decreased expression of TSC22D1 mRNA CTD PMID:18480146 NCBI chr14:76,652,401...76,745,205
Ensembl chr14:76,652,401...76,745,205
JBrowse link
G Tst thiosulfate sulfurtransferase, mitochondrial affects expression ISO coumarin affects the expression of TST mRNA CTD PMID:16963487 NCBI chr15:78,283,756...78,290,065
Ensembl chr15:78,283,756...78,290,107
JBrowse link
G Ttc39a tetratricopeptide repeat domain 39A increases expression ISO coumarin results in increased expression of TTC39A mRNA CTD PMID:18480146 NCBI chr 4:109,251,344...109,301,942
Ensembl chr 4:109,263,820...109,301,942
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO coumarin results in increased expression of TXNRD1 mRNA CTD PMID:18480146 NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546
JBrowse link
G Ugdh UDP-glucose dehydrogenase increases expression ISO coumarin results in increased expression of UGDH mRNA CTD PMID:18480146 NCBI chr 5:65,570,550...65,593,185
Ensembl chr 5:65,570,564...65,593,292
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO coumarin analog results in increased expression of VEGFA mRNA CTD PMID:32578917 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
JBrowse link
G Vim vimentin decreases expression ISO coumarin analog results in decreased expression of VIM protein CTD PMID:32578917 NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637
JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 decreases response to substance
increases response to substance
ISO VKORC1 gene mutant form results in decreased susceptibility to coumarin
VKORC1 gene mutant form results in increased susceptibility to coumarin; VKORC1 promoter SNP results in increased susceptibility to coumarin
CTD PMID:17849045 PMID:18278162 NCBI chr 7:127,492,235...127,494,833
Ensembl chr 7:127,485,399...127,494,626
Ensembl chr 7:127,485,399...127,494,626
JBrowse link
G Wee1 WEE 1 homolog 1 (S. pombe) increases expression ISO coumarin results in increased expression of WEE1 mRNA CTD PMID:18480146 NCBI chr 7:109,721,266...109,742,506
Ensembl chr 7:109,721,253...109,742,493
JBrowse link
G Yrdc yrdC domain containing (E.coli) increases expression ISO coumarin results in increased expression of YRDC mRNA CTD PMID:18480146 NCBI chr 4:124,744,552...124,749,035
Ensembl chr 4:124,744,472...124,749,035
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 decreases expression ISO coumarin analog results in decreased expression of ZEB1 mRNA CTD PMID:32578917 NCBI chr18:5,591,330...5,775,468
Ensembl chr18:5,591,860...5,775,467
JBrowse link
G Zfp444 zinc finger protein 444 increases expression ISO coumarin results in increased expression of ZFP444 mRNA CTD PMID:18480146 NCBI chr 7:6,175,429...6,196,103
Ensembl chr 7:6,175,225...6,196,810
JBrowse link
G Zfp593 zinc finger protein 593 increases expression ISO coumarin results in increased expression of ZNF593 mRNA CTD PMID:18480146 NCBI chr 4:133,970,617...133,972,902
Ensembl chr 4:133,970,600...133,972,903
JBrowse link
G Zwint ZW10 interactor increases expression ISO coumarin results in increased expression of ZWINT mRNA CTD PMID:18480146 NCBI chr10:72,490,678...72,510,796
Ensembl chr10:72,490,677...72,510,796
JBrowse link
coumarin 460 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akap9 A kinase (PRKA) anchor protein (yotiao) 9 increases expression ISO 4-methyl-7-diethylaminocoumarin results in increased expression of AKAP9 mRNA CTD PMID:19502547 NCBI chr 5:3,977,410...4,130,204
Ensembl chr 5:3,978,054...4,131,310
JBrowse link
G Ankrd37 ankyrin repeat domain 37 increases expression ISO 4-methyl-7-diethylaminocoumarin results in increased expression of ANKRD37 mRNA CTD PMID:19502547 NCBI chr 8:46,449,945...46,453,272
Ensembl chr 8:46,449,939...46,458,744
JBrowse link
G Ar androgen receptor multiple interactions
affects localization
ISO 4-methyl-7-diethylaminocoumarin binds to and results in increased activity of AR protein
4-methyl-7-diethylaminocoumarin affects the localization of AR protein
CTD PMID:28478275 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit increases activity ISO 4-methyl-7-diethylaminocoumarin results in increased activity of HIF1A protein CTD PMID:19502547 NCBI chr12:73,948,098...73,994,328
Ensembl chr12:73,948,149...73,994,304
JBrowse link
G Pfkm phosphofructokinase, muscle increases expression ISO 4-methyl-7-diethylaminocoumarin results in increased expression of PFKM mRNA CTD PMID:19502547 NCBI chr15:97,990,470...98,030,328
Ensembl chr15:97,990,470...98,030,332
JBrowse link
G Psph phosphoserine phosphatase increases expression ISO 4-methyl-7-diethylaminocoumarin results in increased expression of PSPH mRNA CTD PMID:19502547 NCBI chr 5:129,842,622...129,864,318
Ensembl chr 5:129,842,622...129,864,513
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO 4-methyl-7-diethylaminocoumarin results in increased expression of VEGFA protein CTD PMID:19502547 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
JBrowse link
DAPI term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asic5 acid-sensing (proton-gated) ion channel family member 5 decreases activity EXP DAPI results in decreased activity of ASIC5 protein CTD PMID:21828194 NCBI chr 3:81,889,600...81,928,540
Ensembl chr 3:81,889,597...81,928,540
JBrowse link
dithiazanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity ISO Dithiazanine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
JBrowse link
eosin YS dye term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Iyd iodotyrosine deiodinase multiple interactions ISO Eosine Yellowish-(YS) inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] CTD PMID:33352258 NCBI chr10:3,490,274...3,504,880
Ensembl chr10:3,490,240...3,504,877
JBrowse link
erythrosin B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A decreases activity ISO Erythrosine results in decreased activity of ABCB1 protein CTD PMID:20041016 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO Erythrosine results in increased expression of CCND1 protein CTD PMID:8927716 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Cdk2 cyclin-dependent kinase 2 increases activity ISO Erythrosine results in increased activity of CDK2 protein CTD PMID:8927716 PMID:9168006 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO Erythrosine results in decreased activity of CYP19A1 protein CTD PMID:18310892 NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394
JBrowse link
G Fosl1 fos-like antigen 1 increases expression EXP Erythrosine results in increased expression of FOSL1 protein CTD PMID:20025956 NCBI chr19:5,497,726...5,505,966
Ensembl chr19:5,497,575...5,505,974
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions ISO Erythrosine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
JBrowse link
G Hpgds hematopoietic prostaglandin D synthase decreases activity ISO Erythrosine results in decreased activity of HPGDS protein CTD PMID:25603235 NCBI chr 6:65,094,277...65,121,961
Ensembl chr 6:65,094,277...65,121,892
JBrowse link
G Iyd iodotyrosine deiodinase decreases activity ISO Erythrosine results in decreased activity of IYD protein CTD PMID:24012475 NCBI chr10:3,490,274...3,504,880
Ensembl chr10:3,490,240...3,504,877
JBrowse link
G Jun jun proto-oncogene increases expression EXP Erythrosine results in increased expression of JUN protein CTD PMID:20025956 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
JBrowse link
G Orm1 orosomucoid 1 increases expression EXP Erythrosine results in increased expression of ORM1 protein CTD PMID:20025956 NCBI chr 4:63,262,793...63,266,400
Ensembl chr 4:63,262,797...63,266,400
JBrowse link
G Phex phosphate regulating endopeptidase homolog, X-linked increases expression EXP Erythrosine results in increased expression of PHEX protein CTD PMID:20025956 NCBI chr  X:155,945,071...156,198,282
Ensembl chr  X:155,945,071...156,198,308
JBrowse link
G Trh thyrotropin releasing hormone multiple interactions ISO Erythrosine promotes the reaction [TRH protein results in increased expression of TSHB protein] CTD PMID:2160137 NCBI chr 6:92,219,042...92,221,631
Ensembl chr 6:92,219,042...92,221,631
JBrowse link
G Trp53 transformation related protein 53 increases activity ISO Erythrosine results in increased activity of TP53 protein CTD PMID:9168006 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Tshb thyroid stimulating hormone, beta subunit multiple interactions ISO Erythrosine promotes the reaction [TRH protein results in increased expression of TSHB protein] CTD PMID:2160137 NCBI chr 3:102,684,621...102,718,175
Ensembl chr 3:102,682,781...102,690,034
JBrowse link
G Ugt1a6b UDP glucuronosyltransferase 1 family, polypeptide A6B decreases activity ISO Erythrosine results in decreased activity of UGT1A6 protein CTD PMID:20041016 NCBI chr 1:88,030,979...88,146,720
Ensembl chr 1:88,030,974...88,146,725
JBrowse link
G Ugt2b34 UDP glucuronosyltransferase 2 family, polypeptide B34 decreases activity ISO Erythrosine results in decreased activity of UGT2B7 protein CTD PMID:20041016 NCBI chr 5:87,037,629...87,054,796
Ensembl chr 5:87,037,626...87,054,796
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression EXP Erythrosine results in increased expression of VEGFA protein CTD PMID:20025956 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
JBrowse link
ethidium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO Ethidium inhibits the reaction [Estradiol results in increased expression of BCL2 mRNA] CTD PMID:15897899 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Ethidium inhibits the reaction [Estradiol results in increased expression of CCND1 mRNA] CTD PMID:15897899 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO Ethidium inhibits the reaction [Estradiol results in increased expression of CCNE1 mRNA] CTD PMID:15897899 NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959
JBrowse link
G Ccne2 cyclin E2 multiple interactions ISO Ethidium inhibits the reaction [Estradiol results in increased expression of CCNE2 mRNA] CTD PMID:15897899 NCBI chr 4:11,190,489...11,204,779
Ensembl chr 4:11,191,351...11,204,779
JBrowse link
G Cd59b CD59b antigen increases mutagenesis ISO Ethidium results in increased mutagenesis of CD59 protein CTD PMID:17045307 NCBI chr 2:103,900,127...103,920,619
Ensembl chr 2:103,900,194...103,921,532
JBrowse link
G Gja1 gap junction protein, alpha 1 increases uptake ISO GJA1 protein results in increased uptake of Ethidium CTD PMID:26926986 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609
JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP Ethidium inhibits the reaction [sodium arsenate results in increased expression of IL1A protein]; Ethidium inhibits the reaction [tributyltin results in increased expression of IL1A protein] CTD PMID:8875956 PMID:10571731 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
JBrowse link
G mt-Co1 cytochrome c oxidase I, mitochondrial decreases expression ISO Ethidium results in decreased expression of COX1 protein CTD PMID:18823003 NCBI chr MT:5,328...6,872
Ensembl chr MT:5,328...6,872
JBrowse link
G mt-Co2 cytochrome c oxidase II, mitochondrial decreases expression ISO Ethidium results in decreased expression of COX2 mRNA CTD PMID:22712077 NCBI chr MT:7,013...7,696
Ensembl chr MT:7,013...7,696
JBrowse link
G mt-Cytb cytochrome b, mitochondrial decreases expression ISO Ethidium results in decreased expression of CYTB mRNA CTD PMID:22712077 NCBI chr MT:14,145...15,288
Ensembl chr MT:14,145...15,288
JBrowse link
G mt-Nd1 NADH dehydrogenase 1, mitochondrial decreases expression ISO Ethidium results in decreased expression of ND1 mRNA CTD PMID:22712077 NCBI chr MT:2,751...3,707
Ensembl chr MT:2,751...3,707
JBrowse link
G mt-Nd4 NADH dehydrogenase 4, mitochondrial decreases expression ISO Ethidium results in decreased expression of ND4 mRNA CTD PMID:22712077 NCBI chr MT:10,167...11,544
Ensembl chr MT:10,167...11,544
JBrowse link
G Nrf1 nuclear respiratory factor 1 increases expression ISO Ethidium results in increased expression of NRF1 mRNA CTD PMID:22712077 NCBI chr 6:30,047,984...30,153,457
Ensembl chr 6:30,047,987...30,153,457
JBrowse link
G P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 decreases transport
increases transport
ISO P2RX7 gene polymorphism results in decreased transport of Ethidium
P2RX7 protein results in increased transport of Ethidium
CTD PMID:16263709 NCBI chr 5:122,781,990...122,830,399
Ensembl chr 5:122,781,974...122,829,495
JBrowse link
G Slc22a1 solute carrier family 22 (organic cation transporter), member 1 multiple interactions
increases uptake
affects uptake
ISO
EXP
1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]; Cimetidine inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]; Quinine inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]; Tetraethylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]
SLC22A1 protein affects the uptake of Ethidium
CTD PMID:19357179 NCBI chr17:12,867,761...12,894,725
Ensembl chr17:12,867,756...12,894,716
JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 affects uptake
multiple interactions
increases uptake
EXP
ISO
SLC22A2 protein affects the uptake of Ethidium
1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]; Cimetidine inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]; Ethidium inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Quinine inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]; Tetraethylammonium inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]
CTD PMID:19357179 NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
JBrowse link
G Slc22a3 solute carrier family 22 (organic cation transporter), member 3 increases uptake
multiple interactions
ISO SLC22A3 protein results in increased uptake of Ethidium
1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]; Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]; Quinine inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]; Tetraethylammonium inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]
CTD PMID:19357179 NCBI chr17:12,638,859...12,726,591
Ensembl chr17:12,637,847...12,726,591
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO Ethidium results in increased expression of TFAM mRNA CTD PMID:22712077 NCBI chr10:71,061,298...71,074,157
Ensembl chr10:71,061,294...71,074,110
JBrowse link
Fast green FCF term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Iyd iodotyrosine deiodinase multiple interactions ISO Fast Green FCF inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] CTD PMID:33352258 NCBI chr10:3,490,274...3,504,880
Ensembl chr10:3,490,240...3,504,877
JBrowse link
Fluo-3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 affects export EXP ABCC1 protein affects the export of Fluo-3 CTD PMID:15948026 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601
JBrowse link
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 multiple interactions
increases secretion
ISO Adenosine Triphosphate promotes the reaction [ABCC2 protein results in increased secretion of Fluo-3]; Cyclosporine inhibits the reaction [ABCC2 protein results in increased secretion of Fluo-3] CTD PMID:9794919 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
JBrowse link
fluorescein (lactone form) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 multiple interactions ISO [CYP2C19 protein results in increased metabolism of dibenzylfluorescein] which results in increased chemical synthesis of Fluorescein; Tranylcypromine inhibits the reaction [[CYP2C19 protein results in increased metabolism of dibenzylfluorescein] which results in increased chemical synthesis of Fluorescein] CTD PMID:23850985 NCBI chr19:39,378,000...39,451,547
Ensembl chr19:39,378,000...39,451,519
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 multiple interactions ISO [CYP2C9 protein results in increased metabolism of dibenzylfluorescein] which results in increased chemical synthesis of Fluorescein; Sulfaphenazole inhibits the reaction [[CYP2C9 protein results in increased metabolism of dibenzylfluorescein] which results in increased chemical synthesis of Fluorescein] CTD PMID:23850985 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 multiple interactions ISO [CYP2C9 protein results in increased metabolism of dibenzylfluorescein] which results in increased chemical synthesis of Fluorescein; Sulfaphenazole inhibits the reaction [[CYP2C9 protein results in increased metabolism of dibenzylfluorescein] which results in increased chemical synthesis of Fluorescein] CTD PMID:23850985 NCBI chr19:39,102,342...39,175,200
Ensembl chr19:39,102,342...39,175,516
JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity ISO Fluorescein results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
JBrowse link
G Slc22a6 solute carrier family 22 (organic anion transporter), member 6 multiple interactions ISO Fluorescein inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:11602689 NCBI chr19:8,595,360...8,605,663
Ensembl chr19:8,595,403...8,605,663
JBrowse link
G Slco1b2 solute carrier organic anion transporter family, member 1b2 multiple interactions
increases uptake
ISO bisphenol A inhibits the reaction [SLCO1B3 protein results in increased uptake of Fluorescein]; bisphenol F promotes the reaction [SLCO1B3 protein results in increased uptake of Fluorescein]; Probenecid inhibits the reaction [SLCO1B3 protein results in increased uptake of Fluorescein]; tetrabromobisphenol A inhibits the reaction [SLCO1B3 protein results in increased uptake of Fluorescein] CTD PMID:27989701 NCBI chr 6:141,575,178...141,632,372
Ensembl chr 6:141,575,244...141,632,372
JBrowse link
G Slco3a1 solute carrier organic anion transporter family, member 3a1 increases uptake
multiple interactions
ISO SLCO3A1 protein results in increased uptake of Fluorescein
Cyclosporine promotes the reaction [SLCO3A1 protein results in increased uptake of Fluorescein]; simvastatin acid affects the reaction [SLCO3A1 protein results in increased uptake of Fluorescein]
CTD PMID:28887287 NCBI chr 7:73,925,166...74,204,528
Ensembl chr 7:73,925,167...74,204,528
JBrowse link
fluorescein 5-isothiocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 affects binding ISO Fluorescein-5-isothiocyanate binds to ABCB7 protein CTD PMID:27129696 NCBI chr  X:103,324,171...103,457,452
Ensembl chr  X:103,324,263...103,457,462
JBrowse link
G Akr1c21 aldo-keto reductase family 1, member C21 increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of AKR1C2 mRNA CTD PMID:20491607 NCBI chr13:4,624,074...4,636,542
Ensembl chr13:4,624,074...4,636,540
JBrowse link
G Anxa4 annexin A4 affects binding ISO Fluorescein-5-isothiocyanate binds to ANXA4 protein CTD PMID:27129696 NCBI chr 6:86,713,822...86,770,616
Ensembl chr 6:86,713,822...86,770,566
JBrowse link
G Arhgap6 Rho GTPase activating protein 6 affects binding ISO Fluorescein-5-isothiocyanate binds to ARHGAP6 protein CTD PMID:27129696 NCBI chr  X:167,578,091...168,087,436
Ensembl chr  X:167,578,095...168,087,431
JBrowse link
G Azi2 5-azacytidine induced gene 2 affects binding ISO Fluorescein-5-isothiocyanate binds to AZI2 protein CTD PMID:27129696 NCBI chr 9:117,869,510...117,898,866
Ensembl chr 9:117,869,567...117,898,862
JBrowse link
G Capzb capping actin protein of muscle Z-line subunit beta affects binding ISO Fluorescein-5-isothiocyanate binds to CAPZB protein CTD PMID:27129696 NCBI chr 4:138,920,210...139,019,131
Ensembl chr 4:138,920,210...139,019,129
JBrowse link
G Cd109 CD109 antigen affects binding ISO Fluorescein-5-isothiocyanate binds to CD109 protein CTD PMID:27129696 NCBI chr 9:78,522,828...78,623,542
Ensembl chr 9:78,522,828...78,623,535
JBrowse link
G Cd180 CD180 antigen affects binding ISO Fluorescein-5-isothiocyanate binds to CD180 protein CTD PMID:27129696 NCBI chr13:102,830,055...102,843,139
Ensembl chr13:102,830,066...102,876,137
JBrowse link
G Cd86 CD86 antigen increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of CD86 protein CTD PMID:19665512 NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443
JBrowse link
G Cd93 CD93 antigen affects binding ISO Fluorescein-5-isothiocyanate binds to CD93 protein CTD PMID:27129696 NCBI chr 2:148,278,571...148,285,455
Ensembl chr 2:148,278,560...148,285,483
JBrowse link
G Cdc20 cell division cycle 20 affects binding ISO Fluorescein-5-isothiocyanate binds to CDC20 protein CTD PMID:27129696 NCBI chr 4:118,290,098...118,294,540
Ensembl chr 4:118,290,098...118,294,549
JBrowse link
G Copa coatomer protein complex subunit alpha affects binding ISO Fluorescein-5-isothiocyanate binds to COPA protein CTD PMID:27129696 NCBI chr 1:171,909,885...171,949,899
Ensembl chr 1:171,910,096...171,949,897
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of CYP1A1 mRNA CTD PMID:20491607 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Dcaf4 DDB1 and CUL4 associated factor 4 affects binding ISO Fluorescein-5-isothiocyanate binds to DCAF4 protein CTD PMID:27129696 NCBI chr12:83,567,145...83,588,768
Ensembl chr12:83,567,240...83,588,694
JBrowse link
G Dot1l DOT1-like, histone H3 methyltransferase (S. cerevisiae) affects binding ISO Fluorescein-5-isothiocyanate binds to DOT1L protein CTD PMID:27129696 NCBI chr10:80,590,935...80,631,295
Ensembl chr10:80,591,040...80,631,295
JBrowse link
G Elac1 elaC ribonuclease Z 1 affects binding ISO Fluorescein-5-isothiocyanate binds to ELAC1 protein CTD PMID:27129696 NCBI chr18:73,868,109...73,887,589
Ensembl chr18:73,868,109...73,887,550
JBrowse link
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 affects binding ISO Fluorescein-5-isothiocyanate binds to ENPP7 protein CTD PMID:27129696 NCBI chr11:118,879,007...118,884,047
Ensembl chr11:118,879,014...118,884,047
JBrowse link
G Flrt3 fibronectin leucine rich transmembrane protein 3 affects binding ISO Fluorescein-5-isothiocyanate binds to FLRT3 protein CTD PMID:27129696 NCBI chr 2:140,500,118...140,513,396
Ensembl chr 2:140,492,834...140,513,389
JBrowse link
G Fn1 fibronectin 1 affects binding ISO Fluorescein-5-isothiocyanate binds to FN1 protein CTD PMID:27129696 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
EXP [Melatonin co-treated with diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased expression of HMOX1 protein
Fluorescein-5-isothiocyanate results in increased expression of HMOX1 protein
CTD PMID:27871981 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Hspa5 heat shock protein 5 affects binding ISO Fluorescein-5-isothiocyanate binds to HSPA5 protein CTD PMID:27129696 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559
JBrowse link
G Hspa9 heat shock protein 9 affects binding ISO Fluorescein-5-isothiocyanate binds to HSPA9 protein CTD PMID:27129696 NCBI chr18:35,070,467...35,087,404
Ensembl chr18:35,070,467...35,087,410
JBrowse link
G Ifng interferon gamma multiple interactions EXP [Dibutyl Phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IFNG protein; [tributyrin co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IFNG protein CTD PMID:29198882 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
JBrowse link
G Ikbkb inhibitor of kappaB kinase beta affects binding ISO Fluorescein-5-isothiocyanate binds to IKBKB protein CTD PMID:27129696 NCBI chr 8:23,149,221...23,196,605
Ensembl chr 8:23,149,228...23,196,605
JBrowse link
G Ikzf4 IKAROS family zinc finger 4 affects binding ISO Fluorescein-5-isothiocyanate binds to IKZF4 protein CTD PMID:27129696 NCBI chr10:128,466,708...128,505,668
Ensembl chr10:128,466,712...128,505,227
JBrowse link
G Il17re interleukin 17 receptor E affects binding ISO Fluorescein-5-isothiocyanate binds to IL17RE protein CTD PMID:27129696 NCBI chr 6:113,435,659...113,447,719
Ensembl chr 6:113,435,445...113,447,719
JBrowse link
G Il31ra interleukin 31 receptor A affects binding ISO Fluorescein-5-isothiocyanate binds to IL31RA protein CTD PMID:27129696 NCBI chr13:112,649,439...112,717,266
Ensembl chr13:112,656,432...112,730,894
JBrowse link
G Il4 interleukin 4 multiple interactions
increases expression
EXP [Dibutyl Phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IL4 protein; [dibutyrylglycerol analog co-treated with Fluorescein-5-isothiocyanate] affects the secretion of IL4 protein; [tributyrin co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IL4 protein; diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL4 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL4 protein]] CTD PMID:27871981 PMID:29198882 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
JBrowse link
G Lypd3 Ly6/Plaur domain containing 3 affects binding ISO Fluorescein-5-isothiocyanate binds to LYPD3 protein CTD PMID:27129696 NCBI chr 7:24,335,995...24,340,543
Ensembl chr 7:24,335,975...24,340,543
JBrowse link
G Maff v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of MAFF mRNA CTD PMID:20491607 NCBI chr15:79,230,821...79,243,278
Ensembl chr15:79,230,821...79,243,276
JBrowse link
G Map3k20 mitogen-activated protein kinase kinase kinase 20 affects binding ISO Fluorescein-5-isothiocyanate binds to MAP3K20 protein CTD PMID:27129696 NCBI chr 2:72,115,970...72,272,954
Ensembl chr 2:72,115,981...72,272,954
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions
ISO Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK1 protein
Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK1 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
CTD PMID:27129696 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
ISO Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK3 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK3 protein
CTD PMID:27129696 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
ISO Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK8 protein
Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK8 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]
CTD PMID:27129696 NCBI chr14:33,099,855...33,169,215
Ensembl chr14:33,099,855...33,169,115
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation
multiple interactions
ISO Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK9 protein
Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK9 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]
CTD PMID:27129696 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248
JBrowse link
G Mt2 metallothionein 2 increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of MT2A mRNA CTD PMID:20491607 NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196
JBrowse link
G Mybpc1 myosin binding protein C, slow-type affects binding ISO Fluorescein-5-isothiocyanate binds to MYBPC1 protein CTD PMID:27129696 NCBI chr10:88,354,141...88,441,051
Ensembl chr10:88,354,141...88,441,014
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions EXP [Melatonin co-treated with diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased expression of NFE2L2 protein CTD PMID:27871981 NCBI chr 2:75,505,857...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression
multiple interactions
ISO
EXP
Fluorescein-5-isothiocyanate results in increased expression of NQO1 mRNA
Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein
diisodecyl phthalate inhibits the reaction [Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein]; Melatonin inhibits the reaction [diisodecyl phthalate inhibits the reaction [Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein]]
CTD PMID:20491607 PMID:27871981 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Plce1 phospholipase C, epsilon 1 affects binding ISO Fluorescein-5-isothiocyanate binds to PLCE1 protein CTD PMID:27129696 NCBI chr19:38,469,438...38,773,549
Ensembl chr19:38,469,557...38,773,474
JBrowse link
G Postn periostin, osteoblast specific factor affects binding ISO Fluorescein-5-isothiocyanate binds to POSTN protein CTD PMID:27129696 NCBI chr 3:54,266,688...54,298,462
Ensembl chr 3:54,268,530...54,298,458
JBrowse link
G Pprc1 peroxisome proliferative activated receptor, gamma, coactivator-related 1 affects binding ISO Fluorescein-5-isothiocyanate binds to PPRC1 protein CTD PMID:27129696 NCBI chr19:46,044,955...46,061,348
Ensembl chr19:46,033,325...46,061,354
JBrowse link
G Prkcb protein kinase C, beta increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of PRKCB protein CTD PMID:31958493 NCBI chr 7:121,888,327...122,233,625
Ensembl chr 7:121,887,974...122,233,625
JBrowse link
G Psd4 pleckstrin and Sec7 domain containing 4 affects binding ISO Fluorescein-5-isothiocyanate binds to PSD4 protein CTD PMID:27129696 NCBI chr 2:24,257,571...24,299,882
Ensembl chr 2:24,257,592...24,304,966
JBrowse link
G Psmd14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 affects binding ISO Fluorescein-5-isothiocyanate binds to PSMD14 protein CTD PMID:27129696 NCBI chr 2:61,542,038...61,630,720
Ensembl chr 2:61,542,038...61,630,720
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP [diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased phosphorylation of RELA protein; Melatonin inhibits the reaction [[diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased phosphorylation of RELA protein] CTD PMID:27871981 NCBI chr19:5,687,569...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Scn5a sodium channel, voltage-gated, type V, alpha affects binding ISO Fluorescein-5-isothiocyanate binds to SCN5A protein CTD PMID:27129696 NCBI chr 9:119,312,470...119,408,096
Ensembl chr 9:119,312,474...119,408,082
JBrowse link
G Skor1 SKI family transcriptional corepressor 1 affects binding ISO Fluorescein-5-isothiocyanate binds to SKOR1 protein CTD PMID:27129696 NCBI chr 9:63,045,446...63,056,243
Ensembl chr 9:63,045,452...63,056,243
JBrowse link
G Slc38a10 solute carrier family 38, member 10 affects binding ISO Fluorescein-5-isothiocyanate binds to SLC38A10 protein CTD PMID:27129696 NCBI chr11:119,994,777...120,042,177
Ensembl chr11:119,994,786...120,042,172
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation
multiple interactions
EXP Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 protein
diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 protein]]
CTD PMID:27871981 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
JBrowse link
G Stat5a signal transducer and activator of transcription 5A increases phosphorylation
multiple interactions
EXP Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT5 protein
diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT5 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT5 protein]]
CTD PMID:27871981 NCBI chr11:100,750,177...100,775,995
Ensembl chr11:100,750,177...100,775,995
JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions
increases phosphorylation
EXP diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein]] CTD PMID:27871981 NCBI chr10:127,478,855...127,496,856
Ensembl chr10:127,478,855...127,496,826
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 affects binding ISO Fluorescein-5-isothiocyanate binds to TRPA1 protein CTD PMID:27129696 NCBI chr 1:14,942,868...14,989,086
Ensembl chr 1:14,942,872...14,989,086
JBrowse link
G Tslp thymic stromal lymphopoietin increases expression
multiple interactions
EXP Fluorescein-5-isothiocyanate results in increased expression of TSLP protein
diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TSLP protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TSLP protein]]
CTD PMID:27871981 NCBI chr18:32,948,436...32,952,852
Ensembl chr18:32,948,436...32,952,850
JBrowse link
G Txn1 thioredoxin 1 increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of TXN mRNA CTD PMID:20491607 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411
JBrowse link
G Usp3 ubiquitin specific peptidase 3 affects binding ISO Fluorescein-5-isothiocyanate binds to USP3 protein CTD PMID:27129696 NCBI chr 9:66,421,573...66,501,996
Ensembl chr 9:66,421,919...66,500,424
JBrowse link
gallein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 multiple interactions ISO gallein inhibits the reaction [Chloroquine affects the localization of SLC2A4 protein] CTD PMID:27160165 NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014
JBrowse link
lucifer yellow dye term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) multiple interactions
increases uptake
increases transport
ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [ABCG2 protein results in increased uptake of lucifer yellow]; Novobiocin inhibits the reaction [ABCG2 protein results in increased uptake of lucifer yellow]; Omeprazole inhibits the reaction [ABCG2 protein results in increased transport of lucifer yellow] CTD PMID:31348918 PMID:32305507 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661
JBrowse link
malachite green cation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase decreases activity ISO malachite green results in decreased activity of BCHE protein CTD PMID:16036213 NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO [Diethylnitrosamine co-treated with malachite green] results in increased expression of CCNB1 mRNA; [Diethylnitrosamine co-treated with malachite green] results in increased expression of CCNB1 protein CTD PMID:12616621 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [Diethylnitrosamine co-treated with malachite green] results in increased expression of CCND1 mRNA; [Diethylnitrosamine co-treated with malachite green] results in increased expression of CCND1 protein; malachite green promotes the reaction [Diethylnitrosamine results in increased expression of CCND1 protein] CTD PMID:10906429 PMID:12616621 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO malachite green promotes the reaction [Diethylnitrosamine results in increased expression of CCNE1 protein] CTD PMID:10906429 NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO [Diethylnitrosamine co-treated with malachite green] results in increased expression of CDK1 mRNA; [Diethylnitrosamine co-treated with malachite green] results in increased expression of CDK1 protein CTD PMID:12616621 NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions ISO [Diethylnitrosamine co-treated with malachite green] results in increased expression of CDK4 mRNA; [Diethylnitrosamine co-treated with malachite green] results in increased expression of CDK4 protein CTD PMID:12616621 NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789
JBrowse link
G Kcna3 potassium voltage-gated channel, shaker-related subfamily, member 3 decreases activity
multiple interactions
ISO malachite green results in decreased activity of KCNA3 protein
[malachite green results in decreased activity of KCNA3 protein] which results in decreased import of Thallium
CTD PMID:21362439 NCBI chr 3:106,943,478...106,945,445
Ensembl chr 3:106,943,485...106,945,386
JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity
multiple interactions
ISO malachite green results in decreased activity of KCNH2 protein
[malachite green results in decreased activity of KCNH2 protein] which results in decreased import of Thallium
CTD PMID:21362439 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
JBrowse link
G Khnyn KH and NYN domain containing affects response to substance ISO KHNYN gene SNP affects the susceptibility to malachite green CTD PMID:25622337 NCBI chr14:56,122,269...56,136,237
Ensembl chr14:56,122,404...56,136,232
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO [Diethylnitrosamine co-treated with malachite green] results in increased expression of PCNA protein; malachite green promotes the reaction [Diethylnitrosamine results in increased expression of PCNA protein] CTD PMID:10906429 PMID:11831363 PMID:12616621 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
JBrowse link
G Rnf150 ring finger protein 150 affects response to substance ISO RNF150 gene SNP affects the susceptibility to malachite green CTD PMID:25622337 NCBI chr 8:83,589,889...83,817,900
Ensembl chr 8:83,589,985...83,817,897
JBrowse link
merbromin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Car2 carbonic anhydrase 2 decreases activity ISO Merbromin results in decreased activity of CA2 protein CTD PMID:16858005 NCBI chr 3:14,951,329...14,965,830
Ensembl chr 3:14,951,333...14,965,830
JBrowse link
G Gsta3 glutathione S-transferase, alpha 3 multiple interactions ISO Merbromin inhibits the reaction [GSTA3 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:21,310,789...21,335,799
Ensembl chr 1:21,310,813...21,335,885
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions ISO Merbromin inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
JBrowse link
methylene blue term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Methylene Blue results in decreased activity of ACHE protein CTD PMID:33844597 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
JBrowse link
G Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide multiple interactions EXP Methylene Blue inhibits the reaction [Sodium Cyanide results in increased phosphorylation of ATP1A2 protein] CTD PMID:31173149 NCBI chr 1:172,099,276...172,125,631
Ensembl chr 1:172,099,276...172,125,631
JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAX protein] CTD PMID:31428839 NCBI chr 7:45,111,119...45,116,344
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of BCL2 protein] CTD PMID:31428839 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit multiple interactions EXP Methylene Blue inhibits the reaction [Sodium Cyanide results in increased phosphorylation of CACNA1C protein] CTD PMID:31173149 NCBI chr 6:118,564,201...119,174,345
Ensembl chr 6:118,564,201...119,173,851
JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha multiple interactions ISO Methylene Blue inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA] CTD PMID:11919648 NCBI chr 7:114,225,223...114,236,145
Ensembl chr 7:114,230,713...114,235,592
JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked increases activity ISO Methylene Blue results in increased activity of G6PD protein CTD PMID:1901343 NCBI chr  X:73,453,089...73,472,486
Ensembl chr  X:73,453,089...73,472,800
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
EXP [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLC mRNA; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of GCLC mRNA] CTD PMID:24556215 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit multiple interactions EXP [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLM mRNA CTD PMID:24556215 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP Methylene Blue inhibits the reaction [MAPT protein mutant form results in increased expression of GFAP mRNA]; Methylene Blue inhibits the reaction [MAPT protein mutant form results in increased expression of GFAP protein] CTD PMID:24556215 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738
JBrowse link
G Glrx glutaredoxin multiple interactions EXP [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX mRNA CTD PMID:24556215 NCBI chr13:75,988,004...75,998,270
Ensembl chr13:75,987,987...75,998,273
JBrowse link
G Glrx2 glutaredoxin 2 (thioltransferase) multiple interactions EXP [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX2 mRNA CTD PMID:24556215 NCBI chr 1:143,614,787...143,625,416
Ensembl chr 1:143,592,076...143,625,414
JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 multiple interactions ISO Methylene Blue inhibits the reaction [manganese chloride results in increased secretion of GNRH1 protein] CTD PMID:17290048 NCBI chr14:67,982,630...67,986,885
Ensembl chr14:67,982,630...67,986,888
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions ISO Methylene Blue inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
EXP
ISO
[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of HMOX1 mRNA; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of HMOX1 mRNA]
Methylene Blue results in increased expression of HMOX1 protein
CTD PMID:24556215 PMID:25943564 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ICAM1 protein] CTD PMID:31428839 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
JBrowse link
G Il17a interleukin 17A multiple interactions ISO Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL17A protein] CTD PMID:31428839 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein] CTD PMID:31428839 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Iyd iodotyrosine deiodinase multiple interactions ISO Methylene Blue inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] CTD PMID:33352258 NCBI chr10:3,490,274...3,504,880
Ensembl chr10:3,490,240...3,504,877
JBrowse link
G Maob monoamine oxidase B multiple interactions
decreases activity
ISO Methylene Blue inhibits the reaction [MAOB protein results in increased oxidation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine]
Methylene Blue results in decreased activity of MAOB protein
CTD PMID:21554916 NCBI chr  X:16,575,520...16,683,605
Ensembl chr  X:16,575,521...16,683,605
JBrowse link
G Mapt microtubule-associated protein tau decreases expression
multiple interactions
decreases phosphorylation
increases expression
ISO
EXP
Methylene Blue results in decreased expression of MAPT protein
[Methylene Blue co-treated with MAPT protein mutant form] affects the localization of NFE2L2 protein; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLC mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLM mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX2 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of HMOX1 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of NFE2L2 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of NQO1 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of PRDX6 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of TXN2 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of TXNRD2 mRNA; Methylene Blue affects the reaction [MAPT protein mutant form affects the expression of TXNRD1 mRNA]; Methylene Blue affects the reaction [MAPT protein mutant form results in increased expression of TXN mRNA]; Methylene Blue co-treated with [MAPT protein mutant form results in increased expression of NOS2 mRNA]; Methylene Blue inhibits the reaction [MAPT protein mutant form results in increased expression of GFAP mRNA]; Methylene Blue inhibits the reaction [MAPT protein mutant form results in increased expression of GFAP protein]
Methylene Blue results in decreased phosphorylation of MAPT protein modified form
Methylene Blue results in increased expression of MAPT mRNA
CTD PMID:16930453 PMID:24556215 NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Methylene Blue inhibits the reaction [Paraquat results in increased expression of MPO protein]; Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MPO protein] CTD PMID:25943564 PMID:31428839 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions EXP
ISO
[Methylene Blue co-treated with MAPT protein mutant form] affects the localization of NFE2L2 protein; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of NFE2L2 mRNA; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of GCLC mRNA]; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of HMOX1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of NQO1 mRNA]
Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of NFE2L2 mRNA]
CTD PMID:24556215 PMID:31428839 NCBI chr 2:75,505,857...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP
ISO
Methylene Blue co-treated with [MAPT protein mutant form results in increased expression of NOS2 mRNA]
Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of NOS2 protein]
CTD PMID:24556215 PMID:31428839 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions
increases expression
EXP [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of NQO1 mRNA; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of NQO1 mRNA] CTD PMID:24556215 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Pgd phosphogluconate dehydrogenase increases activity ISO Methylene Blue results in increased activity of PGD protein CTD PMID:1901343 NCBI chr 4:149,234,448...149,251,162
Ensembl chr 4:149,234,448...149,251,228
JBrowse link
G Prdx6 peroxiredoxin 6 multiple interactions EXP [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of PRDX6 mRNA CTD PMID:24556215 NCBI chr 1:161,067,682...161,078,780
Ensembl chr 1:161,067,682...161,078,789
JBrowse link
G Prkce protein kinase C, epsilon multiple interactions EXP Methylene Blue inhibits the reaction [Sodium Cyanide results in increased activity of and affects the localization of PRKCE protein] CTD PMID:31173149 NCBI chr17:86,472,631...86,965,347
Ensembl chr17:86,475,213...86,965,347
JBrowse link
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 multiple interactions
increases activity
EXP oxophenylarsine inhibits the reaction [Methylene Blue results in increased activity of SLC2A1 protein] CTD PMID:19686715 NCBI chr 4:118,965,942...118,994,527
Ensembl chr 4:118,965,908...118,995,180
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Methylene Blue inhibits the reaction [Nitroglycerin results in decreased expression of TNF protein] CTD PMID:11744139 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Txn1 thioredoxin 1 multiple interactions EXP Methylene Blue affects the reaction [MAPT protein mutant form results in increased expression of TXN mRNA] CTD PMID:24556215 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411
JBrowse link
G Txn2 thioredoxin 2 multiple interactions EXP [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of TXN2 mRNA CTD PMID:24556215 NCBI chr15:77,799,251...77,813,194
Ensembl chr15:77,799,247...77,813,206
JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions EXP Methylene Blue affects the reaction [MAPT protein mutant form affects the expression of TXNRD1 mRNA] CTD PMID:24556215 NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546
JBrowse link
G Txnrd2 thioredoxin reductase 2 multiple interactions EXP [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of TXNRD2 mRNA CTD PMID:24556215 NCBI chr16:18,245,167...18,297,823
Ensembl chr16:18,245,134...18,297,823
JBrowse link
mitoTracker Green FM term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A multiple interactions
increases export
ISO LCL161 inhibits the reaction [ABCB1 protein results in increased export of mitotracker green FM] CTD PMID:32497533 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
JBrowse link
monobromobimane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gstp1 glutathione S-transferase, pi 1 affects metabolic processing ISO GSTP1 protein affects the metabolism of monobromobimane CTD PMID:15355982 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
JBrowse link
monodansylcadaverine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 decreases phosphorylation ISO monodansylcadaverine results in decreased phosphorylation of AKT1 protein CTD PMID:16170020 NCBI chr12:112,620,255...112,641,318
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Bad BCL2-associated agonist of cell death decreases expression ISO monodansylcadaverine results in decreased expression of BAD protein CTD PMID:16170020 NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267
JBrowse link
G Bcl2l11 BCL2-like 11 (apoptosis facilitator) increases expression ISO monodansylcadaverine results in increased expression of BCL2L11 protein CTD PMID:16170020 NCBI chr 2:127,967,958...128,004,467
Ensembl chr 2:127,967,958...128,004,467
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO monodansylcadaverine results in decreased expression of BIRC5 protein CTD PMID:16170020 NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569
JBrowse link
G Ccl25 chemokine (C-C motif) ligand 25 multiple interactions EXP monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL25 protein] CTD PMID:22341560 NCBI chr 8:4,375,207...4,410,020
Ensembl chr 8:4,375,210...4,410,020
JBrowse link
G Ccl5 chemokine (C-C motif) ligand 5 multiple interactions EXP monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL5 protein] CTD PMID:22341560 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344
JBrowse link
G Cxcl12 chemokine (C-X-C motif) ligand 12 multiple interactions EXP monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CXCL12 protein] CTD PMID:22341560 NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression ISO monodansylcadaverine results in decreased expression of GSK3B protein CTD PMID:16170020 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO monodansylcadaverine inhibits the reaction [[IGF1 protein results in increased abundance of Reactive Oxygen Species] which results in increased expression of ZNF143 protein]; monodansylcadaverine inhibits the reaction [IGF1 protein results in increased abundance of Reactive Oxygen Species] CTD PMID:20733350 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904
JBrowse link
G Il12b interleukin 12b multiple interactions EXP monodansylcadaverine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL12B protein] CTD PMID:22341560 NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860
JBrowse link
G Il2 interleukin 2 multiple interactions EXP monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL2 protein] CTD PMID:22341560 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108
JBrowse link
G Il3 interleukin 3 multiple interactions EXP monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL3 protein] CTD PMID:22341560 NCBI chr11:54,155,911...54,158,105
Ensembl chr11:54,156,129...54,158,103
JBrowse link
G Il4 interleukin 4 multiple interactions EXP monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL4 protein] CTD PMID:22341560 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
JBrowse link
G Il6 interleukin 6 multiple interactions EXP monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein] CTD PMID:22341560 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions EXP monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased degradation of IRF3 protein] CTD PMID:22341560 NCBI chr 7:44,647,072...44,652,272
Ensembl chr 7:44,647,072...44,652,272
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions EXP monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein] CTD PMID:22341560 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions EXP monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein] CTD PMID:22341560 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein] CTD PMID:22341560 NCBI chr14:33,099,855...33,169,215
Ensembl chr14:33,099,855...33,169,115
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions EXP monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased activity of NFKB1 protein] CTD PMID:22341560 NCBI chr 3:135,290,416...135,397,728
Ensembl chr 3:135,290,416...135,397,308
JBrowse link
G Tgm2 transglutaminase 2, C polypeptide decreases activity ISO monodansylcadaverine results in decreased activity of TGM2 protein CTD PMID:16382148 NCBI chr 2:157,958,325...157,988,312
Ensembl chr 2:157,958,322...157,988,356
JBrowse link
G Ticam2 toll-like receptor adaptor molecule 2 multiple interactions EXP monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TICAM2 mRNA] CTD PMID:22341560 NCBI chr18:46,691,298...46,707,600
Ensembl chr18:46,690,358...46,707,600
JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 multiple interactions EXP monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TIMP1 protein] CTD PMID:22341560 NCBI chr  X:20,736,405...20,740,976
Ensembl chr  X:20,736,405...20,740,974
JBrowse link
G Timp4 tissue inhibitor of metalloproteinase 4 multiple interactions EXP monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TIMP4 protein] CTD PMID:22341560 NCBI chr 6:115,221,405...115,229,166
Ensembl chr 6:115,218,853...115,229,166
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of TLR4 protein] CTD PMID:22341560 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521
JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a multiple interactions EXP monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNFRSF1A protein] CTD PMID:22341560 NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447
JBrowse link
G Zfp143 zinc finger protein 143 multiple interactions ISO monodansylcadaverine inhibits the reaction [[IGF1 protein results in increased abundance of Reactive Oxygen Species] which results in increased expression of ZNF143 protein] CTD PMID:20733350 NCBI chr 7:109,660,896...109,694,603
Ensembl chr 7:109,660,424...109,694,601
JBrowse link
pararosaniline free base term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase decreases activity ISO pararosaniline results in decreased activity of BCHE protein CTD PMID:16036213 NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions ISO pararosaniline inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases expression
decreases activity
ISO pararosaniline results in decreased expression of NR3C1 protein
pararosaniline results in decreased activity of NR3C1 protein
CTD PMID:19255438 NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474
JBrowse link
phloxine O term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tslp thymic stromal lymphopoietin multiple interactions EXP Phloxine O inhibits the reaction [calcipotriol increases expression of Tslp mRNA and protein in skin of external ear and phorbol 12-myristate 13-acetate increases expression of Tslp protein in keratinocytes] RGD PMID:29310423 RGD:38549374 NCBI chr18:32,948,436...32,952,852
Ensembl chr18:32,948,436...32,952,850
JBrowse link
propidium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity
EXP
ISO
Propidium binds to and results in decreased activity of ACHE protein; Propidium promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; Propidium promotes the reaction [haloxon results in increased phosphorylation of ACHE protein]; Propidium promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein]
Propidium results in decreased activity of ACHE protein
CTD PMID:10421444 PMID:25522658 PMID:27238725 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
JBrowse link
G Bche butyrylcholinesterase decreases activity ISO Propidium results in decreased activity of BCHE protein CTD PMID:31173753 NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 decreases expression ISO Propidium results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Ccl3 chemokine (C-C motif) ligand 3 decreases expression ISO Propidium results in decreased expression of CCL3 protein CTD PMID:20116850 NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181
JBrowse link
G Ccl4 chemokine (C-C motif) ligand 4 decreases expression ISO Propidium results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr11:83,553,410...83,555,509
Ensembl chr11:83,553,410...83,555,509
JBrowse link
G Ccl5 chemokine (C-C motif) ligand 5 decreases expression ISO Propidium results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 decreases expression ISO Propidium results in decreased expression of CXCL8 protein CTD PMID:20116850 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Il6ra interleukin 6 receptor, alpha decreases expression ISO Propidium results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 3:89,776,631...89,820,503
Ensembl chr 3:89,771,366...89,820,503
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Propidium results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
JBrowse link
rhodamine 123 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A multiple interactions
decreases uptake
increases export
ISO 3-methylquercetin inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; 3-methylquercetin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; 5,7-dimethoxyflavone inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; 5,7-dimethoxyflavone inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; 5-hydroxyflavone inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; 5-methoxyflavone inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; 5-oxo-hexahydroquinoline analog inhibits the reaction [ABCB1 protein results in increased export of Rhodamine 123]; [zosuquidar trihydrochloride results in decreased activity of ABCB1 protein] which results in decreased export of Rhodamine 123; abemaciclib inhibits the reaction [ABCB1 protein results in increased export of Rhodamine 123]; baicalein inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; baicalein promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; betulin inhibits the reaction [ABCB1 protein results in increased export of Rhodamine 123]; biochanin A inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; biochanin A promotes the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; CEP 33779 inhibits the reaction [ABCB1 protein results in increased export of Rhodamine 123]; daidzein inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; flavone inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; formononetin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; Genistein promotes the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; glycitein promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; isovitexin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; kaempferol inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; myricetin inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; naringenin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; naringin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; Quercetin inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; Quercetin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; quercitrin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; Rutin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; tangeretin inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; tangeretin inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; taxifolin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of Rhodamine 123]
[P-glycoprotein inducer and activator TX5 results in increased activity of ABCB1 protein] which results in increased export of Rhodamine 123; [Verapamil results in decreased activity of ABCB1 protein] inhibits the reaction [P-glycoprotein inducer and activator TX5 results in increased export of Rhodamine 123]
CTD PMID:25058526 PMID:27816545 PMID:30391378 PMID:31756430 PMID:33321149 More... NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) increases export
multiple interactions
ISO ABCG2 protein results in increased export of Rhodamine 123
abemaciclib inhibits the reaction [ABCG2 protein results in increased export of Rhodamine 123]
CTD PMID:27816545 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661
JBrowse link
rhodamine 6G term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO rhodamine 6G results in decreased activity of ACHE protein CTD PMID:33844597 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
JBrowse link
rose bengal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A decreases activity ISO Rose Bengal results in decreased activity of ABCB1 protein CTD PMID:20041016 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO Rose Bengal results in decreased activity of CYP19A1 protein CTD PMID:18310892 NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394
JBrowse link
G Gsta3 glutathione S-transferase, alpha 3 decreases response to substance ISO GSTA3 protein results in decreased susceptibility to Rose Bengal CTD PMID:1740415 NCBI chr 1:21,310,789...21,335,799
Ensembl chr 1:21,310,813...21,335,885
JBrowse link
G Iyd iodotyrosine deiodinase decreases activity ISO Rose Bengal results in decreased activity of IYD protein CTD PMID:24012475 NCBI chr10:3,490,274...3,504,880
Ensembl chr10:3,490,240...3,504,877
JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity ISO Rose Bengal results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
JBrowse link
G Klkb1 kallikrein B, plasma 1 multiple interactions
decreases response to substance
EXP 7-Ala-angiotensin (1-7) inhibits the reaction [KLKB1 gene mutant form results in decreased susceptibility to Rose Bengal]; nimesulide inhibits the reaction [KLKB1 gene mutant form results in decreased susceptibility to Rose Bengal]; splitomicin inhibits the reaction [KLKB1 gene mutant form results in decreased susceptibility to Rose Bengal] CTD PMID:25339356 NCBI chr 8:45,719,725...45,747,872
Ensembl chr 8:45,719,726...45,747,896
JBrowse link
G Ugt1a6b UDP glucuronosyltransferase 1 family, polypeptide A6B decreases activity ISO Rose Bengal results in decreased activity of UGT1A6 protein CTD PMID:20041016 NCBI chr 1:88,030,979...88,146,720
Ensembl chr 1:88,030,974...88,146,725
JBrowse link
Sirius red 4B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Iyd iodotyrosine deiodinase multiple interactions ISO Direct Red 81 inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] CTD PMID:33352258 NCBI chr10:3,490,274...3,504,880
Ensembl chr10:3,490,240...3,504,877
JBrowse link
Sudan III term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor affects localization
multiple interactions
ISO sudan III affects the localization of AHR protein
[sudan III affects the localization of AHR protein] promotes the reaction [AHR protein binds to ARNT protein]; [sudan III affects the localization of AHR protein] which results in increased expression of CYP1A1 mRNA; sudan III binds to and results in increased activity of AHR protein
[sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased activity of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A23-3A1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 protein]; [sudan III binds to AHR protein] which results in decreased activity of CYP2C11 protein; sudan III binds to and results in increased activity of AHR protein
CTD PMID:15585952 PMID:15788368 PMID:22287322 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO [sudan III affects the localization of AHR protein] promotes the reaction [AHR protein binds to ARNT protein] CTD PMID:22287322 NCBI chr 3:95,341,674...95,404,551
Ensembl chr 3:95,341,699...95,404,551
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
increases activity
ISO sudan III results in increased expression of CYP1A1 mRNA
[sudan III affects the localization of AHR protein] which results in increased expression of CYP1A1 mRNA; NR1I3 protein promotes the reaction [sudan III results in increased expression of CYP1A1 mRNA]
sudan III results in increased activity of CYP1A1 protein
sudan III results in increased expression of CYP1A1 mRNA; sudan III results in increased expression of CYP1A1 protein
CTD PMID:18418879 PMID:20308224 PMID:22287322 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO sudan III results in increased expression of CYP1A2 protein CTD PMID:20308224 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 multiple interactions
decreases expression
ISO [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 protein]; sudan III results in decreased expression of and results in decreased activity of CYP2B1 protein
sudan III results in decreased expression of CYP2B1 mRNA
CTD PMID:15788368 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049
JBrowse link
G Cyp2b13 cytochrome P450, family 2, subfamily b, polypeptide 13 multiple interactions
decreases expression
ISO [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 protein]; sudan III results in decreased expression of and results in decreased activity of CYP2B2 protein
sudan III results in decreased expression of CYP2B2 mRNA
CTD PMID:15788368 NCBI chr 7:25,760,813...25,795,622
Ensembl chr 7:25,760,922...25,795,622
JBrowse link
G Cyp2c52-ps cytochrome P450, family 2, subfamily c, polypeptide 52, pseudogene multiple interactions
decreases expression
ISO [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased activity of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 protein]; [sudan III binds to AHR protein] which results in decreased activity of CYP2C11 protein; sudan III results in decreased expression of and results in decreased activity of CYP2C11 protein
sudan III results in decreased expression of CYP2C11 mRNA
CTD PMID:15788368 NCBI chr19:38,965,106...38,992,071
Ensembl chr19:38,965,091...38,991,733
JBrowse link
G Cyp4a12b cytochrome P450, family 4, subfamily a, polypeptide 12B decreases expression ISO sudan III results in decreased expression of CYP4A1 mRNA CTD PMID:15585952 NCBI chr 4:115,268,821...115,296,231
Ensembl chr 4:115,268,821...115,296,231
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression ISO sudan III results in increased expression of NQO1 mRNA CTD PMID:20308224 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO NR1I3 protein promotes the reaction [sudan III results in increased expression of CYP1A1 mRNA] CTD PMID:22287322 NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression
multiple interactions
ISO sudan III results in decreased expression of PPARA protein
sudan III results in decreased expression of PPARA mRNA
[sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased activity of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A23-3A1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 protein]
CTD PMID:15585952 PMID:15788368 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
JBrowse link
G Rxra retinoid X receptor alpha decreases expression ISO sudan III results in decreased expression of RXRA protein CTD PMID:15585952 NCBI chr 2:27,566,457...27,653,331
Ensembl chr 2:27,566,452...27,652,969
JBrowse link
Sudan IV term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Scarlet Red results in increased expression of CYP1A1 mRNA; Scarlet Red results in increased expression of CYP1A1 protein CTD PMID:18418879 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
texas red term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 increases transport ISO ABCC2 protein results in increased transport of Texas red CTD PMID:32212926 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
JBrowse link
thioflavine T term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
affects binding
ISO [Dichlorvos results in increased phosphorylation of ACHE protein] inhibits the reaction [thioflavin T binds to ACHE protein]; [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased phosphorylation of ACHE protein] inhibits the reaction [thioflavin T binds to ACHE protein]; [thioflavin T binds to ACHE protein] inhibits the reaction [ACHE protein results in increased hydrolysis of Acetylthiocholine]; thioflavin T binds to and results in decreased activity of ACHE protein; thioflavin T inhibits the reaction [hopeahainol A binds to ACHE protein] CTD PMID:18423506 PMID:18602908 PMID:20493829 PMID:27297626 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
JBrowse link
tolonium chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Tolonium Chloride results in decreased activity of ACHE protein CTD PMID:33844597 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
JBrowse link

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  CHEBI ontology 21863
    role 21844
      application 21389