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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:miotic
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Accession:CHEBI:51068 term browser browse the term
Definition:Aa agent causing contraction of the pupil of the eye. Because the size of the pupil is under the antagonistic control of the sympathetic and parasympathetic systems, drugs affecting either system can cause miosis. Drugs that mimic or potentiate the parasympathetic input to the circular constrictor muscle and drugs that inhibit sympathetic input to the radial dilator muscle tend to contract the pupils.
Synonyms:related_synonym: Miotico;   miotics


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carbachol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase affects binding
increases hydrolysis
multiple interactions
ISO Carbachol binds to ACHE protein
ACHE protein results in increased hydrolysis of Carbachol
Atropine inhibits the reaction [Carbachol results in increased metabolism of and results in increased secretion of ACHE protein]; Carbachol results in increased metabolism of and results in increased secretion of ACHE protein
CTD PMID:18602908, PMID:20493829, PMID:23047022 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Adcy5 adenylate cyclase 5 increases response to substance ISO ADCY5 protein results in increased susceptibility to Carbachol CTD PMID:12869393 NCBI chr11:68,695,839...68,842,452
Ensembl chr11:68,695,839...68,842,320
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Carbachol inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein]; Carbachol inhibits the reaction [APP protein modified form results in increased expression of BAX protein]; Carbachol inhibits the reaction [APP protein modified form results in increased expression of FOS protein]; Carbachol inhibits the reaction [APP protein modified form results in increased expression of TRP53 protein] CTD PMID:10758335 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Aqp5 aquaporin 5 affects localization ISO Carbachol affects the localization of AQP5 protein CTD PMID:19443731 NCBI chr 7:141,249,044...141,252,576
Ensembl chr 7:141,249,044...141,252,578
JBrowse link
G Avpr1a arginine vasopressin receptor 1A multiple interactions EXP Carbachol promotes the reaction [[NC 1900 results in increased activity of AVPR1A protein] which results in increased abundance of Calcium]; Nicardipine inhibits the reaction [Carbachol promotes the reaction [[NC 1900 results in increased activity of AVPR1A protein] which results in increased abundance of Calcium]] CTD PMID:12646291 NCBI chr 7:67,341,366...67,345,290
Ensembl chr 7:67,341,080...67,345,308
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Carbachol inhibits the reaction [APP protein modified form results in increased expression of BAX protein]; Carbachol inhibits the reaction [domoic acid results in increased localization of BAX protein] CTD PMID:10758335, PMID:19200344 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions
ISO
EXP
Carbachol results in increased expression of BCL2 protein
Carbachol inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein]
CTD PMID:10758335, PMID:17708838, PMID:19200344 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression
ISO
EXP
Carbachol inhibits the reaction [domoic acid results in increased activity of CASP3 protein]
Carbachol results in decreased expression of CASP3 protein
CTD PMID:17708838, PMID:19200344 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cd40 CD40 molecule multiple interactions
increases expression
ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Carbachol results in increased expression of CD40 protein]; 4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [Carbachol results in increased expression of CD40 protein]; Atropine inhibits the reaction [Carbachol results in increased expression of CD40 protein]; Pirenzepine inhibits the reaction [Carbachol results in increased expression of CD40 protein] CTD PMID:16879495 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 increases activity
multiple interactions
affects binding
ISO Carbachol results in increased activity of CHRM1 protein
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]; 1-oleoyl-2-acetylglycerol promotes the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]; 2-aminoethoxydiphenyl borate inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]; [Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium; Atropine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]; Flufenamic Acid inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]; Gadolinium inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]; Lanthanum inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]; Pirenzepine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]; Thapsigargin inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]
CHRM1 protein binds to Carbachol
[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium; [Carbachol results in increased activity of CHRM1 protein] which results in increased expression of FASLG mRNA; [Carbachol results in increased activity of CHRM1 protein] which results in increased expression of FASLG protein; brucine promotes the reaction [Carbachol binds to CHRM1 protein]
CTD PMID:8683117, PMID:9224827, PMID:11527950, PMID:18316702 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions
affects binding
ISO eburnamonine promotes the reaction [Carbachol binds to CHRM2 protein]
Carbachol binds to and results in increased activity of CHRM2 protein; Carbachol promotes the reaction [CHRM2 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; otenzepad inhibits the reaction [Carbachol promotes the reaction [CHRM2 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]]
CHRM2 protein binds to Carbachol
CTD PMID:9224827, PMID:11181912, PMID:19002953 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions
increases response to substance
affects response to substance
affects binding
increases activity
ISO
EXP
Atropine inhibits the reaction [Carbachol results in increased activity of CHRM3 protein]; brucine promotes the reaction [Carbachol binds to CHRM3 protein]; brucine promotes the reaction [Carbachol results in increased activity of CHRM3 protein mutant form]; Carbachol binds to and results in increased activity of CHRM3 protein; Carbachol binds to and results in increased activity of CHRM3 protein mutant form; Carbachol inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]; Guanylyl Imidodiphosphate inhibits the reaction [Carbachol inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]]; Zinc Oxide promotes the reaction [Carbachol inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]]
[Metoclopramide binds to and results in decreased activity of CHRM3 protein] which results in decreased susceptibility to Carbachol
CHRM3 protein results in increased susceptibility to Carbachol
CHRM3 protein affects the susceptibility to Carbachol
CHRM3 protein binds to Carbachol
CTD PMID:9224827, PMID:14724830, PMID:15105209, PMID:19407017, PMID:20466821, PMID:20708676 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 multiple interactions
affects binding
ISO brucine promotes the reaction [Carbachol binds to CHRM4 protein]
CHRM4 protein binds to Carbachol
CTD PMID:9224827 NCBI chr 3:80,833,272...80,841,165
Ensembl chr 3:80,833,272...80,841,006
JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit affects binding EXP Carbachol binds to [CHRNA3 protein binds to CHRNB4 protein] CTD PMID:15615518 NCBI chr 8:59,594,007...59,607,122
Ensembl chr 8:59,592,403...59,607,275
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions
affects binding
ISO
EXP
Carbachol inhibits the reaction [decamethonium binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol inhibits the reaction [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol inhibits the reaction [methyllycaconitine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]
Carbachol binds to [CHRNA4 protein binds to CHRNB2 protein]
CTD PMID:14645658, PMID:15615518 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions
affects activity
ISO
EXP
1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea promotes the reaction [Carbachol affects the activity of CHRNA7 protein]; Carbachol inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]; Carbachol inhibits the reaction [epibatidine binds to CHRNA7 protein]
Carbachol affects the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]
CTD PMID:10216184, PMID:19448648, PMID:21703337, PMID:29248576 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions
affects binding
ISO
EXP
Carbachol inhibits the reaction [decamethonium binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol inhibits the reaction [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol inhibits the reaction [methyllycaconitine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]
Carbachol binds to [CHRNA4 protein binds to CHRNB2 protein]
CTD PMID:14645658, PMID:15615518 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit affects binding EXP Carbachol binds to [CHRNA3 protein binds to CHRNB4 protein] CTD PMID:15615518 NCBI chr 8:59,610,489...59,629,073
Ensembl chr 8:59,609,693...59,629,133
JBrowse link
G Faslg Fas ligand multiple interactions ISO [Carbachol results in increased activity of CHRM1 protein] which results in increased expression of FASLG mRNA; [Carbachol results in increased activity of CHRM1 protein] which results in increased expression of FASLG protein CTD PMID:8683117 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression
multiple interactions
EXP Carbachol results in increased expression of FGF1 protein
KT 5720 inhibits the reaction [Norepinephrine inhibits the reaction [Carbachol results in increased expression of FGF1 protein]]; Norepinephrine inhibits the reaction [Carbachol results in increased expression of FGF1 protein]
CTD PMID:15264218 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
EXP
ISO
Carbachol results in increased expression of FOS protein
Carbachol inhibits the reaction [APP protein modified form results in increased expression of FOS protein]
CTD PMID:10404113, PMID:10758335, PMID:11074189, PMID:16023590 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gcg glucagon increases secretion
multiple interactions
ISO Carbachol results in increased secretion of GCG protein
NPY protein inhibits the reaction [Carbachol results in increased secretion of GCG protein]
CTD PMID:3329090 NCBI chr 3:48,442,635...48,451,650
Ensembl chr 3:48,442,635...48,451,650
JBrowse link
G Gna11 G protein subunit alpha 11 increases response to substance EXP GNA11 results in increased susceptibility to Carbachol CTD PMID:8014894 NCBI chr 7:11,033,400...11,047,284
Ensembl chr 7:11,033,317...11,047,437
JBrowse link
G Grm4 glutamate metabotropic receptor 4 multiple interactions ISO [Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium; Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]; Pertussis Toxin inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; Scopolamine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; tertiapin inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; Tropicamide inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] CTD PMID:18171729 NCBI chr20:6,745,682...6,791,521
Ensembl chr20:6,745,682...6,791,519
JBrowse link
G Hdc histidine decarboxylase affects response to substance ISO HDC protein affects the susceptibility to Carbachol CTD PMID:12893847 NCBI chr 3:119,057,524...119,075,599
Ensembl chr 3:119,057,517...119,075,619
JBrowse link
G Il10 interleukin 10 affects expression ISO Carbachol affects the expression of IL10 mRNA CTD PMID:15698499 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta affects expression
increases expression
EXP Carbachol affects the expression of IL1B protein
Carbachol results in increased expression of IL1B protein
CTD PMID:16023590, PMID:21121909 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il4 interleukin 4 increases expression ISO Carbachol results in increased expression of IL4 mRNA CTD PMID:15698499 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects response to substance ISO KCNH2 protein mutant form affects the susceptibility to Carbachol CTD PMID:29574456 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions ISO [Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium; Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]; Pertussis Toxin inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; Scopolamine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; tertiapin inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; Tropicamide inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] CTD PMID:18171729 NCBI chr 3:41,019,898...41,181,070
Ensembl chr 3:41,019,898...41,181,070
JBrowse link
G Lyz2 lysozyme 2 affects secretion ISO Carbachol affects the secretion of LYZ protein CTD PMID:15234967 NCBI chr 7:60,335,968...60,341,264
Ensembl chr 7:60,335,969...60,341,264
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
increases activity
EXP
ISO
Calcium deficiency inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; calphostin C inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein; PTK2B protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Ro 31-8220 inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SRC protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Carbachol results in decreased phosphorylation of MAPK1 protein
Carbachol results in increased activity of MAPK1 protein
CTD PMID:9121362, PMID:16877402, PMID:17008368, PMID:19002953, PMID:19017493, PMID:19200344 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases activity
decreases phosphorylation
EXP
ISO
Calcium deficiency inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; calphostin C inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein; PTK2B protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Ro 31-8220 inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SRC protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Carbachol results in increased activity of MAPK3 protein
Carbachol results in decreased phosphorylation of MAPK3 protein
CTD PMID:9121362, PMID:16877402, PMID:17008368, PMID:19002953, PMID:19017493, PMID:19200344 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Myl9 myosin light chain 9 increases phosphorylation EXP Carbachol results in increased phosphorylation of MYL9 protein CTD PMID:17272850 NCBI chr 3:152,857,573...152,863,961
Ensembl chr 3:152,857,592...152,863,960
JBrowse link
G Mylk myosin light chain kinase affects response to substance EXP MYLK protein affects the susceptibility to Carbachol CTD PMID:17272850 NCBI chr11:69,013,060...69,260,039
Ensembl chr11:69,013,050...69,223,158
JBrowse link
G Npy neuropeptide Y multiple interactions ISO NPY protein inhibits the reaction [Carbachol results in increased secretion of GCG protein] CTD PMID:3329090 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Plcb1 phospholipase C beta 1 multiple interactions EXP PLCB1 protein inhibits the reaction [Carbachol results in increased abundance of Inositol Phosphates] CTD PMID:11377826 NCBI chr 3:127,721,244...128,419,565
Ensembl chr 3:128,155,069...128,419,545
JBrowse link
G Prkcz protein kinase C, zeta multiple interactions
increases activity
ISO 1-Butanol inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PRKCZ protein]; Carbachol results in increased phosphorylation of and results in increased activity of PRKCZ protein
Carbachol results in increased activity of PRKCZ protein
CTD PMID:15255942 NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 affects expression EXP Carbachol affects the expression of PTGS2 protein CTD PMID:16023590 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta multiple interactions EXP 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PTK2B protein]; Carbachol results in increased phosphorylation of and results in increased activity of PTK2B protein; Egtazic Acid inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PTK2B protein]; PTK2B protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; PTK2B protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SRC protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PTK2B protein] CTD PMID:16877402 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO 1-Butanol inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; Carbachol results in increased phosphorylation of and results in increased activity of RPS6KB1 protein CTD PMID:15255942 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Sct secretin decreases activity EXP SCT protein results in decreased activity of Carbachol CTD PMID:10198350 NCBI chr 1:214,264,865...214,277,437
Ensembl chr 1:214,264,754...214,265,668
JBrowse link
G Slc9a1 solute carrier family 9 member A1 increases activity ISO Carbachol results in increased activity of SLC9A1 protein CTD PMID:12842825 NCBI chr 5:151,573,122...151,626,360
Ensembl chr 5:151,573,092...151,627,316
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions EXP Carbachol results in increased phosphorylation of and results in increased activity of SRC protein; SRC protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SRC protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SRC protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PTK2B protein] CTD PMID:16877402 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Tnf tumor necrosis factor increases expression
increases activity
decreases expression
multiple interactions
affects expression
EXP
ISO
Carbachol results in increased expression of TNF protein
TNF results in increased activity of Carbachol
Carbachol results in decreased expression of TNF mRNA
TNF protein inhibits the reaction [Carbachol results in increased abundance of Phosphatidic Acids]; TNF protein inhibits the reaction [Carbachol results in increased abundance of phosphatidylbutanol]
Carbachol affects the expression of TNF protein
CTD PMID:11245595, PMID:15086448, PMID:15698499, PMID:16023590, PMID:21121909 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Carbachol inhibits the reaction [APP protein modified form results in increased expression of TRP53 protein] CTD PMID:10758335 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trpc4 transient receptor potential cation channel, subfamily C, member 4 multiple interactions
increases response to substance
increases activity
ISO TRPC4 protein affects the reaction [Carbachol results in increased transport of Barium]; TRPC4 protein affects the reaction [Carbachol results in increased transport of Calcium]
TRPC4 protein results in increased susceptibility to Carbachol
Carbachol results in increased activity of TRPC4 protein
CTD PMID:11830588, PMID:29658714 NCBI chr 2:143,433,102...143,605,757
Ensembl chr 2:143,475,323...143,604,972
JBrowse link
G Trpc5 transient receptor potential cation channel, subfamily C, member 5 multiple interactions ISO Carbachol promotes the reaction [TRPC5 protein results in increased transport of Calcium]; resveratrol inhibits the reaction [Carbachol promotes the reaction [TRPC5 protein results in increased transport of Calcium]] CTD PMID:21127073 NCBI chr  X:115,624,670...115,908,248
Ensembl chr  X:115,627,653...115,908,693
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 multiple interactions
increases activity
ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Carbachol results in increased activity of TRPC6 protein] CTD PMID:17603544 NCBI chr 8:6,811,543...6,917,534
Ensembl chr 8:6,811,543...6,917,535
JBrowse link
ecothiopate iodide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Echothiophate Iodide results in decreased activity of ACHE protein CTD PMID:16978018 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Alb albumin affects binding ISO Echothiophate Iodide binds to ALB protein CTD PMID:15525694 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Bche butyrylcholinesterase decreases activity
multiple interactions
ISO Echothiophate Iodide results in decreased activity of BCHE protein
Echothiophate Iodide inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]
CTD PMID:7377577, PMID:16213467, PMID:17698511, PMID:21802514 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 decreases activity ISO Echothiophate Iodide results in decreased activity of NCEH1 protein CTD PMID:16978018 NCBI chr 2:112,868,834...112,932,622
Ensembl chr 2:112,868,707...112,934,953
JBrowse link
physostigmine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadac arylacetamide deacetylase multiple interactions ISO Physostigmine inhibits the reaction [AADAC protein results in decreased acetylation of Rifabutin]; Physostigmine inhibits the reaction [AADAC protein results in decreased acetylation of Rifampin]; Physostigmine inhibits the reaction [AADAC protein results in decreased acetylation of rifapentine] CTD PMID:21856291 NCBI chr 2:150,146,234...150,157,480
Ensembl chr 2:150,146,234...150,157,480
JBrowse link
G Ache acetylcholinesterase decreases activity
affects expression
multiple interactions
increases expression
ISO
EXP
Physostigmine results in decreased activity of ACHE protein
Physostigmine affects the expression of ACHE mRNA
Physostigmine inhibits the reaction [Streptozocin results in increased activity of ACHE protein]
[Physostigmine co-treated with Dichlorvos] results in decreased activity of ACHE protein; [Physostigmine inhibits the reaction [Soman results in decreased activity of ACHE protein]] which results in decreased carbamoylation of ACHE protein; ALB protein affects the reaction [Physostigmine results in decreased activity of ACHE protein]; Physostigmine inhibits the reaction [Soman results in decreased activity of ACHE protein]
asoxime chloride affects the reaction [Physostigmine results in decreased activity of ACHE protein]; asoxime chloride promotes the reaction [Physostigmine inhibits the reaction [Soman results in decreased activity of ACHE protein]]; Physostigmine affects the expression of and affects the activity of ACHE protein; Physostigmine affects the reaction [Sarin affects the expression of ACHE mRNA]; Physostigmine affects the reaction [Sarin affects the expression of and affects the activity of ACHE protein]; Physostigmine inhibits the reaction [Soman results in decreased activity of ACHE protein]
Physostigmine results in increased expression of ACHE protein
CTD PMID:4859365, PMID:11740913, PMID:14644616, PMID:15586889, PMID:19283689, PMID:21402092, PMID:21414391, PMID:22310180, PMID:26902639, PMID:28499986, PMID:30176331, PMID:30682440 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Alb albumin multiple interactions ISO ALB protein affects the reaction [Physostigmine results in decreased activity of ACHE protein] CTD PMID:26902639 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G App amyloid beta precursor protein increases secretion EXP Physostigmine results in increased secretion of APP protein modified form CTD PMID:7605915, PMID:8624119 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Bche butyrylcholinesterase decreases activity
multiple interactions
EXP Physostigmine results in decreased activity of BCHE protein
Physostigmine inhibits the reaction [Sarin results in decreased activity of BCHE protein]
CTD PMID:19283689 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Ces2h carboxylesterase 2H decreases activity ISO Physostigmine results in decreased activity of CES2 protein CTD PMID:9169443 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Chat choline O-acetyltransferase decreases expression
increases expression
EXP Physostigmine results in decreased expression of CHAT protein
Physostigmine results in increased expression of CHAT protein
CTD PMID:22640809 NCBI chr16:8,576,858...8,686,131
Ensembl chr16:8,577,840...8,686,131
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit affects binding
multiple interactions
ISO Physostigmine binds to [CHRNA4 protein binds to CHRNB2 protein]
Physostigmine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Physostigmine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Physostigmine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Physostigmine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
CTD PMID:14645658, PMID:15733544 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit affects binding
multiple interactions
ISO Physostigmine binds to [CHRNA4 protein binds to CHRNB2 protein]
Physostigmine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Physostigmine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Physostigmine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Physostigmine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
CTD PMID:14645658, PMID:15733544 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO Physostigmine inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA] CTD PMID:24555085 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Physostigmine inhibits the reaction [Scopolamine promotes the reaction [SK&F 82958 results in increased expression of FOS mRNA]]; Physostigmine inhibits the reaction [SK&F 82958 results in increased expression of FOS mRNA] CTD PMID:11337201 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO Physostigmine inhibits the reaction [Streptozocin results in decreased expression of GFAP protein] CTD PMID:28499986 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Hmox1 heme oxygenase 1 affects expression EXP Physostigmine affects the expression of HMOX1 mRNA CTD PMID:22954530 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions EXP [1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine; [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine; tertatolol inhibits the reaction [[1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine]; tertatolol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine] CTD PMID:8539317 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Physostigmine inhibits the reaction [Scopolamine promotes the reaction [SK&F 82958 results in increased expression of JUN mRNA]]; Physostigmine inhibits the reaction [SK&F 82958 results in increased expression of JUN mRNA] CTD PMID:11337201 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions ISO Physostigmine inhibits the reaction [Streptozocin results in decreased expression of MAP2 protein] CTD PMID:28499986 NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions ISO Physostigmine inhibits the reaction [Streptozocin results in decreased phosphorylation of NTRK2 protein] CTD PMID:28499986 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Slc18a3 solute carrier family 18 member A3 increases expression EXP Physostigmine results in increased expression of SLC18A3 protein CTD PMID:22640809 NCBI chr16:8,682,668...8,685,529
Ensembl chr16:8,682,669...8,685,529
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Physostigmine inhibits the reaction [Streptozocin results in decreased expression of SOD2 protein] CTD PMID:28499986 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Syp synaptophysin multiple interactions ISO Physostigmine inhibits the reaction [Streptozocin results in decreased expression of SYP protein] CTD PMID:28499986 NCBI chr  X:15,694,699...15,709,244
Ensembl chr  X:15,695,566...15,707,436
JBrowse link
physostigmine salicylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO physostigmine salicylate results in decreased activity of ACHE protein CTD PMID:623676 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19718
      biological role 19717
        pharmacological role 18795
          neurotransmitter agent 16422
            miotic 65
              carbachol 49
              dapiprazole 0
              ecothiopate + 4
              ecothiopate iodide 4
              physostigmine + 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19718
      application 19363
        pharmaceutical 19235
          drug 19235
            neurotransmitter agent 16422
              miotic 65
                carbachol 49
                dapiprazole 0
                ecothiopate + 4
                ecothiopate iodide 4
                physostigmine + 20
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.