CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: flunisolide
Accession: CHEBI:5106
browse the term
Definition: A cyclic ketal that has formula C24H31FO6.
Synonyms: exact_synonym: 6alpha-fluoro-11beta,21-dihydroxy-16alpha,17alpha-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione
related_synonym: Flunisolide anhydrous; Formula=C24H31FO6; InChI=1S/C24H31FO6/c1-21(2)30-19-9-14-13-8-16(25)15-7-12(27)5-6-22(15,3)20(13)17(28)10-23(14,4)24(19,31-21)18(29)11-26/h5-7,13-14,16-17,19-20,26,28H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,20+,22-,23-,24+/m0/s1; InChIKey=XSFJVAJPIHIPKU-XWCQMRHXSA-N; SMILES=CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO; flunisolida; flunisolidum
xref: CAS:3385-03-3; DrugBank:DB00180; Drug_Central:1201; KEGG:C07005
xref_mesh: MESH:C007734
xref: Patent:GB933867; Patent:US3124571; Patent:US3126375; Wikipedia:Flunisolide
G
Ccl5
C-C motif chemokine ligand 5
multiple interactions
ISO
flunisolide inhibits the reaction [TNF protein results in increased secretion of CCL5 protein]
CTD
PMID:10903220
NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
G
Cyp2s1
cytochrome P450, family 2, subfamily s, polypeptide 1
decreases expression
ISO
flunisolide results in decreased expression of CYP2S1 mRNA
CTD
PMID:22155357
NCBI chr 1:81,309,948...81,325,303
Ensembl chr 1:81,310,451...81,325,303
G
Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
increases expression multiple interactions
ISO
flunisolide results in increased expression of CYP3A5 mRNA Ketoconazole inhibits the reaction [flunisolide results in increased expression of CYP3A5 mRNA]
CTD
PMID:24555085
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
G
Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases activity
ISO
flunisolide results in increased activity of NR1I2 protein
CTD
PMID:21068194
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
G
Pgr
progesterone receptor
multiple interactions
ISO
flunisolide binds to and results in increased activity of PGR protein
CTD
PMID:25752796
NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
G
Spp1
secreted phosphoprotein 1
increases expression
ISO
flunisolide results in increased expression of SPP1 protein
CTD
PMID:21885873
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
G
Tgm2
transglutaminase 2
increases expression
ISO
flunisolide results in increased expression of TGM2 protein
CTD
PMID:21885873
NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
G
Tnf
tumor necrosis factor
multiple interactions
ISO
flunisolide inhibits the reaction [TNF protein results in increased secretion of CCL5 protein]
CTD
PMID:10903220
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all