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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tegaserod
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Accession:CHEBI:51043 term browser browse the term
Definition:A hydrazine that has formula C16H23N5O.
Synonyms:exact_synonym: 2-[(5-methoxy-2,3-dihydro-1H-indol-3-yl)methylene]-N-pentylhydrazinecarboximidamide
 related_synonym: 1-(((5-Methoxyindol-3-yl)methylene)amino)-3-pentylguanidine;   Formula=C16H23N5O;   InChI=1S/C16H23N5O/c1-3-4-5-8-18-16(17)21-20-11-12-10-19-15-7-6-13(22-2)9-14(12)15/h6-7,9-11,19H,3-5,8H2,1-2H3,(H3,17,18,21)/b20-11+;   InChIKey=IKBKZGMPCYNSLU-RGVLZGJSSA-N;   SMILES=CCCCCNC(=N)N\\N=C\\c1c[nH]c2ccc(OC)cc12;   tegaserodum
 xref: CAS:145158-71-0;   DrugBank:DB01079;   KEGG:D06056
 xref_mesh: MESH:C105050
 xref: Patent:EP505322;   Patent:US5510353;   Wikipedia:Tegaserod


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tegaserod term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO tegaserod results in decreased activity of CYP1A2 protein CTD PMID:11560869 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
multiple interactions
decreases activity
ISO CYP2D6 protein results in increased metabolism of tegaserod
Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of tegaserod]
tegaserod results in decreased activity of CYP2D6 protein
CTD PMID:11560869 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO tegaserod binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Htr4 5-hydroxytryptamine receptor 4 multiple interactions ISO tegaserod binds to and results in increased activity of HTR4 protein CTD PMID:15238200 PMID:15961989 NCBI chr18:57,637,013...57,820,317
Ensembl chr18:57,654,290...57,819,698
JBrowse link
G Pgr progesterone receptor multiple interactions ISO tegaserod binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO tegaserod binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link

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  CHEBI ontology 19773
    role 19723
      application 19413
        pharmaceutical 19301
          drug 19301
            gastrointestinal drug 321
              tegaserod 6
                tegaserod maleate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    p-block element atom 19665
                      carbon group element atom 19583
                        carbon atom 19573
                          organic molecular entity 19573
                            organic molecule 19505
                              organic cyclic compound 19332
                                organic heterocyclic compound 18519
                                  organic heteropolycyclic compound 17979
                                    organic heterobicyclic compound 16780
                                      benzopyrrole 9542
                                        indoles 9214
                                          tegaserod 6
                                            tegaserod maleate 0
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