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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tegaserod
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Accession:CHEBI:51043 term browser browse the term
Definition:A hydrazine that has formula C16H23N5O.
Synonyms:exact_synonym: 2-[(5-methoxy-2,3-dihydro-1H-indol-3-yl)methylene]-N-pentylhydrazinecarboximidamide
 related_synonym: 1-(((5-Methoxyindol-3-yl)methylene)amino)-3-pentylguanidine;   Formula=C16H23N5O;   InChI=1S/C16H23N5O/c1-3-4-5-8-18-16(17)21-20-11-12-10-19-15-7-6-13(22-2)9-14(12)15/h6-7,9-11,19H,3-5,8H2,1-2H3,(H3,17,18,21)/b20-11+;   InChIKey=IKBKZGMPCYNSLU-RGVLZGJSSA-N;   SMILES=CCCCCNC(=N)N\\N=C\\c1c[nH]c2ccc(OC)cc12;   tegaserodum
 xref: CAS:145158-71-0;   DrugBank:DB01079;   KEGG:D06056
 xref_mesh: MESH:C105050
 xref: Patent:EP505322;   Patent:US5510353;   Wikipedia:Tegaserod



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tegaserod term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO tegaserod results in decreased activity of CYP1A2 protein CTD PMID:11560869 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
multiple interactions
decreases activity
ISO CYP2D6 protein results in increased metabolism of tegaserod
Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of tegaserod]
tegaserod results in decreased activity of CYP2D6 protein
CTD PMID:11560869 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO tegaserod binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Htr4 5-hydroxytryptamine receptor 4 multiple interactions ISO tegaserod binds to and results in increased activity of HTR4 protein CTD PMID:15238200 PMID:15961989 NCBI chr18:55,765,981...55,949,921
Ensembl chr18:55,766,725...55,949,321
JBrowse link
G Pgr progesterone receptor multiple interactions ISO tegaserod binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO tegaserod binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
JBrowse link

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  CHEBI ontology 20072
    role 20026
      application 19773
        pharmaceutical 19647
          drug 19647
            gastrointestinal drug 338
              tegaserod 6
                tegaserod maleate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20072
    subatomic particle 20071
      composite particle 20071
        hadron 20071
          baryon 20071
            nucleon 20071
              atomic nucleus 20071
                atom 20071
                  main group element atom 19974
                    p-block element atom 19974
                      carbon group element atom 19903
                        carbon atom 19896
                          organic molecular entity 19896
                            organic molecule 19844
                              organic cyclic compound 19605
                                organic heterocyclic compound 18890
                                  organic heteropolycyclic compound 18300
                                    organic heterobicyclic compound 17202
                                      benzopyrrole 9639
                                        indoles 9303
                                          tegaserod 6
                                            tegaserod maleate 0
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