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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:epinastine
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Accession:CHEBI:51032 term browser browse the term
Definition:A benzazepine that is 6,11-dihydro-5H-dibenzo[b,e]azepine in which the azepine ring is fused to the e side of 4,5-dihydro-1H-imidazol-2-amine.
Synonyms:exact_synonym: 9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-3-amine
 related_synonym: 3-amino-9,13b-dihydro-1H-dibenz(c,f)imidazo(1,5-a)azepine;   Formula=C16H15N3;   InChI=1S/C16H15N3/c17-16-18-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)19(15)16/h1-8,15H,9-10H2,(H2,17,18);   InChIKey=WHWZLSFABNNENI-UHFFFAOYSA-N;   SMILES=NC1=NCC2N1c1ccccc1Cc1ccccc21;   epinastina;   epinastinum
 xref: Beilstein:3593307;   CAS:80012-43-7;   DrugBank:DB00751;   Drug_Central:1027;   KEGG:D07900
 xref_mesh: MESH:C053090
 xref: Patent:GB2071095;   Patent:US4313931;   Reaxys:3593307;   Wikipedia:Epinastine


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epinastine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects transport ISO ABCB1A affects the transport of epinastine CTD PMID:15100174 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B affects transport ISO ABCB1B affects the transport of epinastine CTD PMID:15100174 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions EXP [epinastine binds to and results in decreased activity of HRH1 protein] which affects the susceptibility to Histamine; epinastine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA] CTD PMID:12832840 PMID:19075512 NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455 		JBrowse link
G Ifng interferon gamma multiple interactions ISO epinastine inhibits the reaction [IL4 results in decreased expression of IFNG] CTD PMID:16534218 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il13 interleukin 13 decreases expression ISO epinastine results in decreased expression of IL13 mRNA; epinastine results in decreased expression of IL13 protein CTD PMID:16534218 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO
EXP		 epinastine inhibits the reaction [IL4 results in decreased expression of IFNG]
epinastine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]		 CTD PMID:16534218 PMID:19075512 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 decreases expression ISO epinastine results in decreased expression of IL5 mRNA; epinastine results in decreased expression of IL5 protein CTD PMID:16534218 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Il6 interleukin 6 decreases expression ISO epinastine results in decreased expression of IL6 mRNA; epinastine results in decreased expression of IL6 protein CTD PMID:16534218 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO epinastine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Ngf nerve growth factor decreases expression ISO epinastine results in decreased expression of NGF protein CTD PMID:19937255 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO epinastine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      biological role 19805
        pharmacological role 19054
          antagonist 17239
            histamine antagonist 4891
              epinastine 11
                R-epinastine 0
                S-epinastine 0
                epinastine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            organic molecule 19677
                              organic cyclic compound 19490
                                organic heterocyclic compound 18852
                                  organic heteropolycyclic compound 18295
                                    organic heterobicyclic compound 17240
                                      benzazepine 536
                                        epinastine 11
                                          R-epinastine 0
                                          S-epinastine 0
                                          epinastine hydrochloride 0
paths to the root